Detailed information for compound 1145659

Basic information

Technical information
  • TDR Targets ID: 1145659
  • Name: 5-[[2-(2-methoxyethyl)-3-methylimidazol-3-ium -1-yl]methyl]-3,3-di(phenyl)oxolan-2-one
  • MW: 391.483 | Formula: C24H27N2O3+
  • H donors: 0 H acceptors: 1 LogP: 3.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCc1n(CC2OC(=O)C(C2)(c2ccccc2)c2ccccc2)cc[n+]1C
  • InChi: 1S/C24H27N2O3/c1-25-14-15-26(22(25)13-16-28-2)18-21-17-24(23(27)29-21,19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-12,14-15,21H,13,16-18H2,1-2H3/q+1
  • InChiKey: XVXBICDHKJQEJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[2-(2-methoxyethyl)-3-methyl-imidazol-3-ium-1-yl]methyl]-3,3-di(phenyl)tetrahydrofuran-2-one
  • 5-[[2-(2-methoxyethyl)-3-methyl-1-imidazol-3-iumyl]methyl]-3,3-di(phenyl)-2-tetrahydrofuranone
  • 5-[[2-(2-methoxyethyl)-3-methyl-imidazol-3-ium-1-yl]methyl]-3,3-di(phenyl)oxolan-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0418 0.0985 0.2199
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0422 0.0419
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0016 0.0013
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0072 0.0141 0.4088
Brugia malayi hypothetical protein 0.0051 0.009 0.019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0016 0.0038
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0203 0.0461 0.1904
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.059 1
Leishmania major hypothetical protein, conserved 0.0078 0.0158 0.0636
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0072 0.0141 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0016 0.0038
Mycobacterium ulcerans hypothetical protein 0.0109 0.0233 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.0078 0.4773
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0471 0.1114 0.2488
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0015 0.0011
Mycobacterium ulcerans beta-lactamase 0.0109 0.0233 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0016 0.0038
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0006 0.0003
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.059 0.1314
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0072 0.0141 0.0817
Loa Loa (eye worm) beta-lactamase 0.0109 0.0233 0.051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0016 0.0038
Brugia malayi glutathione reductase 0.0046 0.0078 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0422 0.1263
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.059 1
Brugia malayi CXXC zinc finger family protein 0.0061 0.0115 0.0247
Entamoeba histolytica hypothetical protein 0.0147 0.0324 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0383 0.6491
Entamoeba histolytica hypothetical protein 0.0147 0.0324 1
Onchocerca volvulus 0.0146 0.0322 0.6878
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0233 0.0693
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0422 0.1263
Brugia malayi ecdysteroid receptor 0.002 0.0016 0.0025
Mycobacterium tuberculosis Conserved protein 0.0109 0.0233 0.137
Echinococcus granulosus proteasome prosome macropain 0.0072 0.0141 0.0416
Loa Loa (eye worm) hypothetical protein 0.0176 0.0395 0.0873
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.004
Onchocerca volvulus 0.0052 0.0093 0.1717
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.059 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0016 0.0025
Toxoplasma gondii ABC1 family protein 0.0109 0.0233 0.9071
Echinococcus multilocularis microtubule associated protein 2 0.1375 0.3317 0.3314
Loa Loa (eye worm) latrophilin receptor protein 2 0.0194 0.0438 0.097
Brugia malayi latrophilin 2 splice variant baaae 0.0418 0.0985 0.2201
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0282 0.0653 0.1454
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0233 0.0512
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0158 0.6059
Brugia malayi Thioredoxin reductase 0.0046 0.0078 0.0163
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0006 0.0008
Brugia malayi TAR-binding protein 0.0642 0.1532 0.3428
Trypanosoma cruzi hypothetical protein, conserved 0.0203 0.0461 0.1904
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0233 0.395
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0146 0.0322 0.0712
Schistosoma mansoni hypothetical protein 0.0035 0.0052 0.0147
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1843 0.4458 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.059 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0068 0.2497
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0019
Toxoplasma gondii proteasome subunit beta type, putative 0.0072 0.0141 0.541
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0233 0.0952
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0233 0.395
Leishmania major carnitine/choline acetyltransferase, putative 0.0203 0.0461 0.1904
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0015 0.0425
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0015 0.0034
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0194 0.0438 0.1312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0016 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0376 0.6365
Schistosoma mansoni cpg binding protein 0.0061 0.0115 0.0337
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0078 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0005 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0324 0.0967
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0015 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0016 0.0038
Mycobacterium tuberculosis Conserved protein 0.0109 0.0233 0.137
Schistosoma mansoni hypothetical protein 0.0707 0.169 0.5089
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0126 0.0726
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0126 0.0505
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0016 0.0038
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0233 0.0693
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0006 0.0008
Brugia malayi beta-lactamase family protein 0.0109 0.0233 0.0512
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.004
Echinococcus multilocularis survival motor neuron protein 1 0.0716 0.1711 0.1708
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0016 0.0013
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0093 0.0269
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0612 0.1457 0.3258
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0221 0.7367
Loa Loa (eye worm) hypothetical protein 0.0109 0.0233 0.051
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.006 0.3567
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0016 0.0038
Trypanosoma brucei trypanothione reductase 0.0046 0.0078 0.1194
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0072 0.0141 0.0568
Schistosoma mansoni hypothetical protein 0.0194 0.0438 0.1312
Loa Loa (eye worm) TAR-binding protein 0.0642 0.1532 0.3426
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0233 0.0952
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0015 0.004
Mycobacterium ulcerans lipase LipD 0.0109 0.0233 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0221 0.1293
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0015 0.0034
Schistosoma mansoni hypothetical protein 0.0418 0.0985 0.2963
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0016 0.0025
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0005 0.0083
Echinococcus granulosus smad 0.0016 0.0006 0.0008
Onchocerca volvulus 0.0109 0.0233 0.4878
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0015 0.0019
Echinococcus granulosus cpg binding protein 0.0064 0.0124 0.0363
Schistosoma mansoni coup transcription factor 0.002 0.0016 0.0038
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0005
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0203 0.0461 0.1024
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0158 0.0636
Loa Loa (eye worm) acetyltransferase 0.0141 0.0311 0.0685
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.004
Schistosoma mansoni microtubule-associated protein tau 0.1375 0.3317 1
Trypanosoma cruzi hypothetical protein, conserved 0.0203 0.0461 0.1904
Brugia malayi nuclear receptor NHR-88 0.002 0.0016 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0158 0.0636
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0068 0.0194
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.006 0.3994
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0311 0.0308
Leishmania major hypothetical protein, conserved 0.0109 0.0233 0.0952
Schistosoma mansoni Smad4 0.0016 0.0006 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0233 0.395
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0233 0.137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0016 0.0022
Echinococcus multilocularis tumor protein p63 0.0353 0.0828 0.0825
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0233 0.395
Loa Loa (eye worm) hypothetical protein 0.0612 0.1457 0.3258
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0078 0.3188
Loa Loa (eye worm) hypothetical protein 0.0203 0.0461 0.1022
Schistosoma mansoni tar DNA-binding protein 0.0642 0.1532 0.4612
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0016 0.0038
Plasmodium vivax glutathione reductase, putative 0.0046 0.0078 0.3188
Treponema pallidum NADH oxidase 0.0016 0.0005 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0194 0.0438 0.1312
Loa Loa (eye worm) glutathione reductase 0.0046 0.0078 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0158 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0126 0.5302
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0016 0.0013
Echinococcus granulosus dna polymerase kappa 0.002 0.0015 0.0034
Echinococcus multilocularis geminin 0.0707 0.169 0.1687
Loa Loa (eye worm) choline O-acetyltransferase 0.0203 0.0461 0.1022
Schistosoma mansoni hypothetical protein 0.0194 0.0438 0.1312
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0126 0.0123
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0203 0.0461 0.1022
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0109 0.0233 0.051
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.059 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0013 0.0027
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0008
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0008
Brugia malayi beta-lactamase family protein 0.0109 0.0233 0.0512
Brugia malayi steroid hormone receptor 0.002 0.0016 0.0025
Brugia malayi hypothetical protein 0.0716 0.1711 0.383
Echinococcus granulosus dna polymerase eta 0.002 0.0015 0.0034
Brugia malayi hypothetical protein 0.0147 0.0324 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Schistosoma mansoni hypothetical protein 0.0441 0.1041 0.3132
Brugia malayi hypothetical protein 0.0078 0.0158 0.0342
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0015 0.0022
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0015 0.0247
Brugia malayi Proteasome A-type and B-type family protein 0.0072 0.0141 0.0306
Echinococcus multilocularis Smad4 0.0016 0.0006 0.0003
Schistosoma mansoni cpg binding protein 0.0064 0.0124 0.0363
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0126 0.037
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0203 0.0461 0.1904
Loa Loa (eye worm) hypothetical protein 0.0109 0.0233 0.051
Trypanosoma cruzi hypothetical protein, conserved 0.0203 0.0461 0.1904
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0233 0.137
Brugia malayi Latrophilin receptor protein 2 0.0194 0.0438 0.0972
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0078 0.0224
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0257 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0115 0.0245
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0229
Loa Loa (eye worm) hypothetical protein 0.0109 0.0233 0.051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0016 0.0013
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0203 0.0461 0.706
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0422 0.0419
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Mycobacterium ulcerans proteasome PrcB 0.0072 0.0141 0.5964
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0282 0.0653 0.1961
Brugia malayi beta-lactamase 0.0109 0.0233 0.0512
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0233 0.137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0612 0.1457 0.326
Schistosoma mansoni hypothetical protein 0.0147 0.0324 0.0967
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.0422 0.0934
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0016 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0194 0.0438 0.0972
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0233 0.3572
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0282 0.0653 0.1456
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0072 0.0141 0.0416
Leishmania major DNA polymerase kappa, putative 0.002 0.0015 0.004
Loa Loa (eye worm) hypothetical protein 0.0109 0.0233 0.051
Echinococcus granulosus microtubule associated protein 2 0.1375 0.3317 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0282 0.084
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0282 0.0653 0.065
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0999 0.2401 0.2398
Echinococcus granulosus tar DNA binding protein 0.0642 0.1532 0.4612
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.034
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0016 0.0038
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0015 0.0247
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0126 0.5302
Trichomonas vaginalis esterase, putative 0.0109 0.0233 0.395
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0249 0.1463
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0006 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0249 0.1463
Onchocerca volvulus 0.0203 0.0461 1
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0376 0.8079
Echinococcus granulosus Smad4 0.0016 0.0006 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.059 0.1312
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0699 0.1671 1
Mycobacterium leprae Probable lipase LipE 0.0109 0.0233 0.8557
Loa Loa (eye worm) RNA binding protein 0.0642 0.1532 0.3426
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0013 0.0009
Onchocerca volvulus 0.0203 0.0461 1
Echinococcus granulosus choline O acetyltransferase 0.0203 0.0461 0.1381
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0203 0.0461 0.1904
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0016 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0249 1
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0158 0.2413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0016 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0441 0.1041 0.3132
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0005 0.0081
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0016 0.0038
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0016 0.0038
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0068 0.1147
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0016 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0324 0.0321
Echinococcus multilocularis proteasome (prosome, macropain) 0.0072 0.0141 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0078 0.0437
Onchocerca volvulus 0.0109 0.0233 0.4878
Loa Loa (eye worm) hypothetical protein 0.1843 0.4458 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0302 0.09
Brugia malayi Calcitonin receptor-like protein seb-1 0.0612 0.1457 0.326
Loa Loa (eye worm) hypothetical protein 0.0194 0.0438 0.097
Brugia malayi RNA binding protein 0.0642 0.1532 0.3428
Schistosoma mansoni tar DNA-binding protein 0.0642 0.1532 0.4612
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0229
Schistosoma mansoni hypothetical protein 0.0146 0.0322 0.0962
Echinococcus granulosus geminin 0.0707 0.169 0.5089
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0203 0.0461 0.1904
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0233 0.137
Echinococcus granulosus tumor protein p63 0.0353 0.0828 0.2488
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0642 0.1532 0.4612
Trypanosoma cruzi hypothetical protein, conserved 0.0203 0.0461 0.1904
Echinococcus multilocularis cpg binding protein 0.0064 0.0124 0.012
Trypanosoma brucei unspecified product 0.002 0.0015 0.0229
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0203 0.0461 0.1904
Echinococcus multilocularis dna polymerase kappa 0.002 0.0015 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0015 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0016 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0016 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0016 0.0022
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0072 0.0141 0.2163
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0015 0.0058
Leishmania major proteasome beta 5 subunit, putative 0.0072 0.0141 0.0568
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0311 0.0687
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0016 0.0013
Leishmania major DNA polymerase eta, putative 0.002 0.0015 0.004
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0158 0.6679
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0376 0.6365
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0016 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0376 0.6365
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.0549 0.1218
Plasmodium falciparum proteasome subunit beta type-5 0.0072 0.0141 0.8929
Plasmodium vivax proteasome subunit beta type-5, putative 0.0072 0.0141 0.5964
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0422 0.1263
Entamoeba histolytica hypothetical protein 0.0147 0.0324 1
Echinococcus multilocularis GPCR, family 2 0.0194 0.0438 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0016 0.0025
Onchocerca volvulus 0.0203 0.0461 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0005 0.5
Onchocerca volvulus 0.0061 0.0115 0.2225
Schistosoma mansoni smad 0.0016 0.0006 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0398 0.6738
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0999 0.2401 1
Schistosoma mansoni cpg binding protein 0.0064 0.0124 0.0363
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0233 0.0693
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0068 0.1147
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0233 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0016 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0126 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0016 0.0022
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0194 0.0438 0.1312
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Entamoeba histolytica hypothetical protein 0.0147 0.0324 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0005 0.5
Mycobacterium tuberculosis Conserved protein 0.0109 0.0233 0.137
Brugia malayi Choline O-acetyltransferase 0.0203 0.0461 0.1024
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0002
Onchocerca volvulus 0.0203 0.0461 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.0422 0.0936
Echinococcus multilocularis dna polymerase eta 0.002 0.0015 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0376 0.6365
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0999 0.2401 1
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0233 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0052 0.0049
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0282 0.0653 0.2706
Leishmania major trypanothione reductase 0.0046 0.0078 0.0304
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0642 0.1532 0.3426
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0072 0.0141 0.2389
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0016 0.0025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0015 0.0058
Brugia malayi Choline O-acetyltransferase 0.0203 0.0461 0.1024
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0376 0.6365
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0016 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0016 0.0025
Echinococcus granulosus GPCR family 2 0.0194 0.0438 0.1312
Giardia lamblia DINP protein human, muc B family 0.002 0.0015 0.0713
Brugia malayi MH2 domain containing protein 0.0239 0.0549 0.122
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0126 0.4809
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0233 0.051
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0398 0.6738
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0006 0.0003
Schistosoma mansoni nuclear hormone receptor 0.002 0.0016 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0233 0.395
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0999 0.2401 1
Loa Loa (eye worm) hypothetical protein 0.0716 0.1711 0.3829
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0016 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0422 0.1263
Schistosoma mansoni choline o-acyltransferase 0.0203 0.0461 0.1381
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.059 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0016 0.0013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0081
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0233 0.137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0016 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0376 0.6365
Schistosoma mansoni thyroid hormone receptor 0.002 0.0016 0.0038
Echinococcus granulosus survival motor neuron protein 1 0.0716 0.1711 0.5152
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0016 0.0038
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0015 0.0229
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0012 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0016 0.0025
Brugia malayi follicle stimulating hormone receptor 0.0471 0.1114 0.249
Echinococcus multilocularis choline O acetyltransferase 0.0203 0.0461 0.0458
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0221 0.1293
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0376 0.6365
Trypanosoma brucei hypothetical protein, conserved 0.0203 0.0461 0.706
Leishmania major carnitine palmitoyltransferase-like protein 0.0282 0.0653 0.2706
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0422 0.1263
Brugia malayi nuclear hormone receptor 0.002 0.0016 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.0549 0.1218
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0078 0.0304
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0013 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0233 0.137
Echinococcus granulosus FTZ F1 alpha 0.002 0.0016 0.0038
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0005 0.0083
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0068 0.2752
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0282 0.0653 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.006 0.1444
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0221 0.1293
Schistosoma mansoni DNA polymerase eta 0.002 0.0015 0.0034
Schistosoma mansoni thyroid hormone receptor 0.002 0.0016 0.0038
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0233 0.023
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0016 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0016 0.0025
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0203 0.0461 0.706
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Echinococcus multilocularis tar DNA binding protein 0.0642 0.1532 0.1529
Schistosoma mansoni choline o-acyltransferase 0.0203 0.0461 0.1381
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0072 0.0141 1
Schistosoma mansoni tar DNA-binding protein 0.0642 0.1532 0.4612
Schistosoma mansoni hypothetical protein 0.0194 0.0438 0.1312
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0052 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.0109 0.0233 0.051
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0999 0.2401 0.7235
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Onchocerca volvulus 0.0109 0.0233 0.4878
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0233 0.137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0194 0.0438 0.0435
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0311 0.0929
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0176 0.0395 0.0875
Echinococcus multilocularis smad 0.0016 0.0006 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.1041 0.1038
Schistosoma mansoni hypothetical protein 0.0707 0.169 0.5089
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0016 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0249 0.1463
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0068 0.2497
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0022
Plasmodium falciparum glutathione reductase 0.0046 0.0078 0.4773
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0158 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0016 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0324 0.0967
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0015 0.0034
Mycobacterium tuberculosis Probable reductase 0.0104 0.0221 0.1293
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0233 0.8557
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0233 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0016 0.0025
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0194 0.0438 0.0435
Brugia malayi Smad1 0.0016 0.0006 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0016 0.0022
Schistosoma mansoni survival motor neuron protein 0.0146 0.0322 0.0962
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0126 0.037
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0221 0.1293
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0005 0.0081
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0203 0.0461 0.706
Schistosoma mansoni tar DNA-binding protein 0.0642 0.1532 0.4612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0016 0.0022
Toxoplasma gondii thioredoxin reductase 0.0046 0.0078 0.2892
Trypanosoma cruzi hypothetical protein, conserved 0.0203 0.0461 0.1904
Brugia malayi RNA recognition motif domain containing protein 0.0642 0.1532 0.3428
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0016 0.0038
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0072 0.0141 0.0568
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0126 0.5302
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0221 0.1293
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0016 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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