Detailed information for compound 1150221

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 294.265 | Formula: C15H10N4O3
  • H donors: 1 H acceptors: 4 LogP: 0.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cnccn1)N/N=C/c1cc(=O)c2c(o1)cccc2
  • InChi: 1S/C15H10N4O3/c20-13-7-10(22-14-4-2-1-3-11(13)14)8-18-19-15(21)12-9-16-5-6-17-12/h1-9H,(H,19,21)/b18-8+
  • InChiKey: DTPBSJVSXBMKEA-QGMBQPNBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.1933 0.461
Echinococcus multilocularis glycyl tRNA synthetase 0.0031 0.0059 0.014
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Plasmodium vivax calcium-dependent protein kinase, putative 0.0171 0.0652 0.0648
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0019 0.0061
Echinococcus granulosus pyruvate kinase 0.0019 0.0007 0.0017
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0085 0.1069
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0171 0.0652 0.0648
Echinococcus multilocularis lamin dm0 0.0055 0.0159 0.038
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.076 0.1811
Trichomonas vaginalis CAMK family protein kinase 0.0171 0.0652 0.2821
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0019 0.0005 0.0012
Schistosoma mansoni hypothetical protein 0.0096 0.0335 0.1438
Echinococcus multilocularis short transient receptor potential channel 6 0.0138 0.0513 0.1223
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0396 0.1614 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0263 0.0258
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0019 0.0005 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Plasmodium falciparum hexose transporter 0.0557 0.2299 0.2295
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0078 0.0259 0.1107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0148
Plasmodium falciparum proline--tRNA ligase 0.0195 0.0755 0.0751
Plasmodium falciparum lysine--tRNA ligase 0.0124 0.0455 0.045
Giardia lamblia Hexose transporter 0.0078 0.0259 0.1578
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0167 0.0637 0.1519
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0167 0.0637 0.1519
Brugia malayi intermediate filament protein 0.0055 0.0159 0.0673
Echinococcus multilocularis pyruvate kinase 0.0019 0.0007 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0104
Giardia lamblia Fructose-bisphosphate aldolase 0.0333 0.1345 0.8328
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0078 0.0256 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.0153
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0078 0.0259 0.0617
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0163 0.0622 0.2995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0117 0.049
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0085 0.035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0246
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0019 0.0005 0.0002
Brugia malayi jmjC domain containing protein 0.0039 0.009 0.037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0126
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Chlamydia trachomatis thioredoxin reductase 0.0163 0.0622 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0371 0.0885
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0059 0.0177 0.2784
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0124 0.0455 0.6932
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Loa Loa (eye worm) hypothetical protein 0.0079 0.0263 0.1123
Echinococcus multilocularis dna polymerase eta 0.0022 0.0019 0.0045
Loa Loa (eye worm) hypothetical protein 0.0077 0.0255 0.1089
Onchocerca volvulus Putative transporter 0.0078 0.0259 0.4043
Echinococcus granulosus glycyl tRNA synthetase 0.0031 0.0059 0.014
Trichomonas vaginalis glucose transporter, putative 0.0078 0.0259 0.1107
Chlamydia trachomatis threonine--tRNA ligase 0.0031 0.0059 0.087
Schistosoma mansoni glucose transporter 0.0078 0.0259 0.1107
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0031 0.0059 0.0234
Schistosoma mansoni hypothetical protein 0.0036 0.0076 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.0153
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0019 0.0005 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0245 0.0583
Trypanosoma cruzi hexose transporter, putative 0.0173 0.0661 0.8747
Onchocerca volvulus 0.0078 0.0259 0.4043
Giardia lamblia Pyruvate kinase 0.0019 0.0007 0.0014
Plasmodium falciparum pyruvate kinase 0.0038 0.0085 0.008
Giardia lamblia Thioredoxin reductase 0.0163 0.0622 0.3832
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.009 0.0214
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0255 0.025
Leishmania major hypothetical protein, conserved 0.0028 0.0043 0.0508
Echinococcus multilocularis solute carrier family 22 0.0078 0.0259 0.0617
Mycobacterium ulcerans hypothetical protein 0.0077 0.0255 0.4052
Schistosoma mansoni glucose transport protein 0.0557 0.2299 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0195 0.0755 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0117 0.1498
Loa Loa (eye worm) hypothetical protein 0.0167 0.0637 0.2756
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0063 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0104
Schistosoma mansoni hypothetical protein 0.0135 0.05 0.2161
Giardia lamblia GTOR 0.0045 0.0117 0.0698
Echinococcus granulosus pyruvate kinase 0.0019 0.0007 0.0017
Chlamydia trachomatis pyruvate kinase 0.0038 0.0085 0.13
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0661 0.2861
Brugia malayi Latrophilin receptor protein 2 0.0135 0.05 0.2161
Schistosoma mansoni lysyl-tRNA synthetase 0.0124 0.0455 0.1962
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0085 0.035
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0031 0.0059 0.0715
Echinococcus multilocularis pyruvate kinase 0.0038 0.0085 0.0203
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0163 0.0622 0.2689
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0263 0.3434
Echinococcus multilocularis muscleblind protein 1 0.017 0.0651 0.1552
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Schistosoma mansoni transient receptor potential channel 4 0.0209 0.0814 0.3527
Echinococcus granulosus TRP transient receptor potential channel 0.0078 0.0256 0.0609
Loa Loa (eye worm) MH2 domain-containing protein 0.0384 0.1562 0.6789
Loa Loa (eye worm) hypothetical protein 0.0055 0.0159 0.0673
Treponema pallidum fructose-bisphosphate aldolase 0.0333 0.1345 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Plasmodium falciparum protein kinase 7 0.1574 0.6632 0.663
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.09 0.3761 0.3758
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0019 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus granulosus GPCR family 2 0.0135 0.05 0.1193
Echinococcus granulosus solute carrier family 22 0.0078 0.0259 0.0617
Brugia malayi hypothetical protein 0.0471 0.1933 0.8407
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0007 0.0002
Echinococcus granulosus short transient receptor potential channel 6 0.0138 0.0513 0.1223
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0019 0.0186
Echinococcus granulosus Sugar transporter ERD6 protein 0.0078 0.0259 0.0617
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0041 0.0036
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0171 0.0652 0.1554
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0117 0.1498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0275
Leishmania major glucose transporter, lmgt2 0.0173 0.0661 0.8747
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0117 0.049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0019 0.0185
Echinococcus multilocularis transient receptor potential gamma protein 0.0209 0.0814 0.1941
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0041 0.0158
Plasmodium vivax glycine--tRNA ligase, putative 0.0031 0.0059 0.0054
Echinococcus multilocularis Smad4 0.0026 0.0037 0.0087
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0167 0.0637 0.2756
Leishmania major histidyl-tRNA synthetase, putative 0.0019 0.0005 0.0005
Loa Loa (eye worm) beta-lactamase 0.0077 0.0255 0.1089
Echinococcus granulosus short transient receptor potential channel 6 0.0138 0.0513 0.1223
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0109 0.039 0.1677
Echinococcus multilocularis transient receptor potential ion channel A 0.0202 0.0784 0.187
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.009 0.037
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0171 0.0652 0.0977
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0117 0.049
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0255 0.1172
Echinococcus granulosus pyruvate kinase 0.0038 0.0085 0.0203
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0063 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0104
Onchocerca volvulus 0.0096 0.0335 0.5596
Giardia lamblia Prolyl-tRNA synthetase 0.0167 0.0637 0.3928
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0085 0.0488
Brugia malayi lysyl-tRNA synthetase 0.0124 0.0455 0.1962
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0085 0.035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.076 0.1811
Mycobacterium tuberculosis Conserved protein 0.0077 0.0255 0.1172
Echinococcus multilocularis peregrin 0.0032 0.0061 0.0146
Entamoeba histolytica hypothetical protein 0.0075 0.0245 0.1489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.076 0.1811
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0085 0.035
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Trypanosoma cruzi hexose transporter, putative 0.0078 0.0259 0.3384
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0041 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0089 0.0367
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0078 0.0259 0.3384
Loa Loa (eye worm) transcription factor SMAD2 0.0384 0.1562 0.6789
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0038 0.0091
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.09 0.3761 0.5668
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0041 0.0483
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0005 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0263 0.3434
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0037 0.0087
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0031 0.0059 0.0334
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0255 0.3331
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0335 0.1438
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0138
Treponema pallidum thioredoxin reductase (trxB) 0.0163 0.0622 0.4601
Mycobacterium ulcerans integral membrane transport protein 0.0078 0.0259 0.4117
Schistosoma mansoni threonyl-tRNA synthetase 0.0019 0.0005 0.0002
Schistosoma mansoni protein kinase 0.0171 0.0652 0.2821
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0333 0.1345 0.8328
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0167 0.0637 0.3928
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0259 0.1107
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0031 0.0059 0.0334
Brugia malayi PHD-finger family protein 0.0032 0.0061 0.0246
Onchocerca volvulus 0.0078 0.0259 0.4043
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0195 0.0755 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0061 0.0246
Brugia malayi Sugar transporter family protein 0.0557 0.2299 1
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus granulosus transient receptor potential ion channel A 0.0202 0.0784 0.187
Brugia malayi jmjC domain containing protein 0.0105 0.0371 0.1596
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0171 0.0652 0.1554
Entamoeba histolytica hypothetical protein 0.0075 0.0245 0.1489
Schistosoma mansoni sugar transporter 0.0078 0.0259 0.1107
Echinococcus multilocularis General substrate transporter 0.0479 0.1965 0.4685
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0245 0.1045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0494 0.2032 1
Brugia malayi follicle stimulating hormone receptor 0.0249 0.0988 0.4285
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0031 0.0059 0.0234
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0171 0.0652 0.2821
Chlamydia trachomatis proline--tRNA ligase 0.0059 0.0177 0.2784
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0126
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0041 0.0098
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Giardia lamblia PHD finger protein 15 0.0032 0.0061 0.035
Toxoplasma gondii sugar transporter ST2 0.0078 0.0259 0.0383
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0061
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0028 0.0043 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0557 0.2299 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0078 0.0259 0.0254
Echinococcus granulosus smad 0.0026 0.0037 0.0087
Schistosoma mansoni hypothetical protein 0.0135 0.05 0.2161
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0037 0.0138
Giardia lamblia DINP protein human, muc B family 0.0022 0.0019 0.0086
Plasmodium vivax sugar transporter, putative 0.0078 0.0259 0.0254
Loa Loa (eye worm) hypothetical protein 0.0054 0.0155 0.0654
Trichomonas vaginalis chaperonin, putative 0.0027 0.0041 0.0158
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0063 0.0777
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0061 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0117 0.049
Leishmania major glucose transporter/membrane transporter D2, putative 0.0173 0.0661 0.8747
Schistosoma mansoni histidyl-tRNA synthetase 0.0019 0.0005 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0019 0.0226
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0038 0.0091
Schistosoma mansoni survival motor neuron protein 0.0096 0.0335 0.1438
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0115 0.0273
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0124 0.0455 0.7296
Echinococcus granulosus geminin 0.0521 0.2147 0.5119
Loa Loa (eye worm) hypothetical protein 0.0135 0.05 0.2161
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0117 0.1498
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Trichomonas vaginalis esterase, putative 0.0077 0.0255 0.1089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0104
Onchocerca volvulus 0.0078 0.0259 0.4043
Onchocerca volvulus 0.0078 0.0259 0.4043
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0167 0.0637 1
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0019 0.0005 0.0012
Toxoplasma gondii sugar transporter ST1 0.0078 0.0259 0.0383
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0263 0.0258
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0063 0.0777
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0333 0.1345 0.8328
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0255 0.3564
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0031 0.0059 0.0262
Echinococcus multilocularis pyruvate kinase 0.0019 0.0007 0.0017
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0195 0.0755 1
Trichomonas vaginalis glucose transporter, putative 0.0173 0.0661 0.2861
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0078 0.0976
Brugia malayi Major Facilitator Superfamily protein 0.0078 0.0259 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Mycobacterium ulcerans lipase LipD 0.0077 0.0255 0.4052
Chlamydia trachomatis histidine--tRNA ligase 0.0019 0.0005 0.0006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0135 0.05 0.1193
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0167 0.0637 0.2756
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0104
Entamoeba histolytica hypothetical protein 0.0124 0.0455 0.2796
Plasmodium falciparum mitogen-activated protein kinase 2 0.09 0.3761 0.3758
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0085 0.008
Brugia malayi major facilitator superfamily protein 0.0078 0.0259 0.1107
Onchocerca volvulus 0.0055 0.0159 0.2006
Trypanosoma cruzi hexose transporter, putative 0.0094 0.0327 0.4299
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0069 0.0217 0.0926
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0195 0.0755 1
Schistosoma mansoni transient receptor potential channel 0.0138 0.0513 0.2215
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Echinococcus granulosus histidyl tRNA synthetase 0.0019 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0031 0.0059 0.087
Echinococcus multilocularis geminin 0.0521 0.2147 0.5119
Plasmodium falciparum calcium-dependent protein kinase 1 0.0171 0.0652 0.0648
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0019 0.0061
Schistosoma mansoni hypothetical protein 0.0521 0.2147 0.9338
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0041 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.009 0.037
Giardia lamblia Threonyl-tRNA synthetase 0.0031 0.0059 0.0334
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0031 0.0059 0.0716
Trichomonas vaginalis sugar transporter, putative 0.0173 0.0661 0.2861
Trypanosoma brucei THT1 - hexose transporter, putative 0.0173 0.0661 0.8747
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0255 0.1089
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0037 0.0138
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0063 0.0777
Onchocerca volvulus 0.0078 0.0259 0.4043
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0255 0.1089
Trypanosoma cruzi hexose transporter, putative 0.0173 0.0661 0.8747
Trypanosoma cruzi hexose transporter 0.0173 0.0661 0.8747
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0037 0.0087
Echinococcus granulosus pyruvate kinase 0.0019 0.0007 0.0017
Leishmania major pyruvate kinase 0.0038 0.0085 0.1069
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0255 0.1172
Entamoeba histolytica protein kinase, putative 0.0171 0.0652 0.402
Onchocerca volvulus 0.0077 0.0255 0.3961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0078 0.0318
Loa Loa (eye worm) latrophilin receptor protein 2 0.0135 0.05 0.2161
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0255 0.1172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Onchocerca volvulus 0.0078 0.0259 0.4043
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0041 0.0158
Schistosoma mansoni pyruvate kinase 0.0019 0.0007 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0078 0.0318
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0019 0.0061
Onchocerca volvulus 0.0078 0.0259 0.4043
Loa Loa (eye worm) hypothetical protein 0.0292 0.1168 0.5072
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Trypanosoma brucei glucose transporter 2A 0.0173 0.0661 0.8747
Schistosoma mansoni hypothetical protein 0.0135 0.05 0.2161
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0041 0.0484
Trypanosoma cruzi sugar transporter, putative 0.0078 0.0259 0.3384
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0159 0.0673
Leishmania major hypothetical protein, conserved 0.0028 0.0043 0.0508
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0078 0.0259 0.4117
Echinococcus multilocularis pyruvate kinase 0.0019 0.0007 0.0017
Echinococcus multilocularis histidyl tRNA synthetase 0.0019 0.0005 0.0012
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0041 0.0158
Schistosoma mansoni hypothetical protein 0.0521 0.2147 0.9338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.076 0.3291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0275
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0163 0.0622 0.2689
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0557 0.2299 0.5481
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0063 0.0254
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0085 0.0708
Echinococcus granulosus muscleblind protein 0.017 0.0651 0.1552
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0255 0.1172
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0171 0.0652 0.2821
Schistosoma mansoni hypothetical protein 0.0032 0.0061 0.0246
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0019 0.0061
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0028 0.0043 0.0509
Brugia malayi Muscleblind-like protein 0.017 0.0651 0.2816
Mycobacterium ulcerans hypothetical protein 0.0028 0.0043 0.0618
Loa Loa (eye worm) hypothetical protein 0.0055 0.0158 0.067
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0124 0.0455 0.7296
Leishmania major hypothetical protein, conserved 0.0078 0.0259 0.3384
Plasmodium vivax hexose transporter 0.0557 0.2299 0.2295
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Plasmodium falciparum calcium-dependent protein kinase 3 0.0171 0.0652 0.0648
Schistosoma mansoni histidyl-tRNA synthetase 0.0019 0.0005 0.0002
Brugia malayi MH2 domain containing protein 0.0026 0.0037 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.005 0.0199
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0041 0.0158
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0085 0.13
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0019 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0078 0.0318
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0019 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.0153
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0117 0.1498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.005 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0275
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0078 0.0259 0.4117
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0163 0.0622 0.2689
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0019 0.0185
Schistosoma mansoni transient receptor potential channel 0.0138 0.0513 0.2215
Loa Loa (eye worm) hypothetical protein 0.0077 0.0255 0.1089
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0037 0.0138
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0263 0.0389
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0061 0.0085
Echinococcus granulosus pyruvate kinase 0.0038 0.0085 0.0203
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0427 0.1744 0.7581
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0206 0.0878
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0019 0.0086
Brugia malayi MH1 domain containing protein 0.0026 0.0037 0.0138
Toxoplasma gondii protein kinase, putative 0.1574 0.6632 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0171 0.0652 0.1554
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0557 0.2299 0.5481
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0028 0.0043 0.012
Schistosoma mansoni lamin 0.0055 0.0159 0.0673
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0117 0.1498
Echinococcus granulosus lysyl tRNA synthetase 0.0124 0.0455 0.1084
Echinococcus granulosus Threonyl tRNA synthetase C 0.0031 0.0059 0.014
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.005 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0063 0.0777
Brugia malayi glycyl-tRNA synthetase 0.0031 0.0059 0.0234
Loa Loa (eye worm) hypothetical protein 0.0427 0.1744 0.7581
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0195 0.0755 1
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0005 0.0012
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0085 0.1069
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0124 0.0455 0.5997
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0078 0.0318
Trypanosoma cruzi histidyl-tRNA synthetase 0.0019 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0255 0.1089
Trypanosoma brucei unspecified product 0.0022 0.0019 0.0186
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0031 0.0059 0.0234
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Trichomonas vaginalis myo-inositol transporter, putative 0.0078 0.0259 0.1107
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0171 0.0652 0.0648
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0019 0.0005 0.0002
Brugia malayi hypothetical protein 0.0078 0.0259 0.1107
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0019 0.0061
Plasmodium falciparum calcium-dependent protein kinase 2 0.0171 0.0652 0.0648
Echinococcus multilocularis pyruvate kinase 0.0038 0.0085 0.0203
Onchocerca volvulus 0.0078 0.0259 0.4043
Loa Loa (eye worm) hypothetical protein 0.0471 0.1933 0.8407
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0117 0.0279
Echinococcus multilocularis lysyl tRNA synthetase 0.0124 0.0455 0.1084
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0259 0.1107
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0063 0.0058
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0115 0.0273
Onchocerca volvulus 0.0078 0.0259 0.4043
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0043 0.0508
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Brugia malayi Transient-receptor-potential like protein 0.0078 0.0256 0.1093
Echinococcus multilocularis GPCR, family 2 0.0135 0.05 0.1193
Brugia malayi latrophilin 2 splice variant baaae 0.0292 0.1168 0.5072
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0019 0.0005 0.0005
Brugia malayi isocitrate dehydrogenase 0.0032 0.0063 0.0254
Entamoeba histolytica hypothetical protein 0.0075 0.0245 0.1489
Toxoplasma gondii ABC1 family protein 0.0077 0.0255 0.0377
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0104
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0117 0.0698
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0135 0.05 0.2161
Schistosoma mansoni protein kinase 0.0171 0.0652 0.2821
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0061 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Onchocerca volvulus 0.0078 0.0259 0.4043
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Loa Loa (eye worm) hypothetical protein 0.0147 0.055 0.2376
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0061 0.0146
Giardia lamblia DNA repair protein RAD52 0.0396 0.1614 1
Leishmania major protein kinase, putative 0.0171 0.0652 0.8623
Loa Loa (eye worm) hypothetical protein 0.017 0.0651 0.2816
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0159 0.0673
Loa Loa (eye worm) hypothetical protein 0.0131 0.0483 0.2086
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0117 0.049
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0171 0.0652 0.0977
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0263 0.3435
Echinococcus multilocularis solute carrier family 22 0.0078 0.0259 0.0617
Giardia lamblia Lysyl-tRNA synthetase 0.0124 0.0455 0.2796
Onchocerca volvulus 0.0078 0.0259 0.4043
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0255 0.3331
Onchocerca volvulus 0.0055 0.0159 0.2006
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0041 0.0225
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0031 0.0059 0.0715
Leishmania major pyruvate kinase 0.0038 0.0085 0.1069
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0031 0.0059 0.0234
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0007 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0019 0.0226
Trypanosoma cruzi hexose transporter, putative 0.0173 0.0661 0.8747
Plasmodium falciparum calcium-dependent protein kinase 5 0.0171 0.0652 0.0648
Loa Loa (eye worm) hypothetical protein 0.0077 0.0255 0.1089
Loa Loa (eye worm) hypothetical protein 0.0171 0.0652 0.2821
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.0652 0.2821
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0255 0.1172
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0063 0.0088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0255 0.0607
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0063 0.0151
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0078 0.0259 0.4117
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0255 0.1089
Trichomonas vaginalis glucose transporter, putative 0.0173 0.0661 0.2861
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0031 0.0059 0.0234
Echinococcus granulosus dna polymerase eta 0.0022 0.0019 0.0045
Schistosoma mansoni pyruvate kinase 0.0038 0.0085 0.035
Leishmania major glucose transporter, lmgt3 0.0173 0.0661 0.8747
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0171 0.0652 0.1554
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0063 0.0151
Plasmodium falciparum phd finger protein, putative 0.0032 0.0061 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0019 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0019 0.0185
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0195 0.0755 0.1132
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0085 0.0329
Echinococcus granulosus dna polymerase kappa 0.0022 0.0019 0.0045
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0106 0.0375 0.1769
Leishmania major lysyl-tRNA synthetase, putative 0.0124 0.0455 0.5997
Brugia malayi Cam kinase protein 1 0.0171 0.0652 0.2821
Echinococcus multilocularis muscleblind protein 0.017 0.0651 0.1552
Treponema pallidum prolyl-tRNA synthetase 0.0059 0.0177 0.1281
Onchocerca volvulus 0.0077 0.0255 0.3961
Onchocerca volvulus 0.0147 0.055 1
Echinococcus multilocularis solute carrier family 22 0.0078 0.0259 0.0617
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0007 0.0003
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0138
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0085 0.0488
Loa Loa (eye worm) hypothetical protein 0.0077 0.0255 0.1089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.009 0.037
Brugia malayi beta-lactamase 0.0077 0.0255 0.1089
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0085 0.035
Echinococcus granulosus synaptic vesicle 2 protein 0.0078 0.0259 0.0617
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0031 0.0059 0.0198
Plasmodium falciparum threonine--tRNA ligase 0.0031 0.0059 0.0054
Brugia malayi MH2 domain containing protein 0.0384 0.1562 0.6789
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0255 0.4052
Loa Loa (eye worm) major facilitator superfamily transporter 0.0078 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0077 0.0255 0.1089
Echinococcus granulosus lamin dm0 0.0055 0.0159 0.038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0135 0.05 0.1193
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0159 0.0673
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0557 0.2299 0.5481
Toxoplasma gondii facilitative glucose transporter GT1 0.0557 0.2299 0.3462
Loa Loa (eye worm) hypothetical protein 0.0209 0.0814 0.3527
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0427 0.1744 0.7581
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0029 0.0104
Toxoplasma gondii lysine-tRNA ligase 0.0124 0.0455 0.0679
Schistosoma mansoni sugar transporter 0.0078 0.0259 0.1107
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.1933 0.461
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0063 0.0088
Echinococcus multilocularis musashi 0.0055 0.0159 0.038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0245 0.0583
Echinococcus multilocularis calcium dependent protein kinase 0.016 0.0607 0.1447
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0043 0.0508
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.009 0.0214
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0557 0.2299 0.5481
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0019 0.0005 0.0002
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0019 0.0005 0.0006
Loa Loa (eye worm) major facilitator superfamily transporter 0.0078 0.0259 0.1107
Echinococcus granulosus peregrin 0.0032 0.0061 0.0146
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0263 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0255 0.1089
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0255 0.4052
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0255 0.1089
Brugia malayi hypothetical protein 0.0079 0.0263 0.1123
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0076 0.0182
Trypanosoma brucei THT1 - hexose transporter, putative 0.0173 0.0661 0.8747
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.0988 0.4285
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0078 0.0975
Toxoplasma gondii sugar transporter ST3 0.0078 0.0259 0.0383
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0255 0.1089
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0171 0.0652 0.2821
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0557 0.2299 0.5481
Schistosoma mansoni protein kinase 0.0171 0.0652 0.2821
Entamoeba histolytica hypothetical protein 0.0113 0.0406 0.249
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0031 0.0059 0.087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0255 0.1089
Loa Loa (eye worm) hypothetical protein 0.017 0.0651 0.2816
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0063 0.022
Brugia malayi MH2 domain containing protein 0.0026 0.0037 0.0138
Onchocerca volvulus 0.0078 0.0259 0.4043
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0037 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0275
Schistosoma mansoni glucose transport protein 0.0557 0.2299 1
Echinococcus granulosus transient receptor potential gamma protein 0.0209 0.0814 0.1941
Echinococcus granulosus solute carrier family 22 0.0078 0.0259 0.0617
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0068 0.0095
Schistosoma mansoni glycyl-tRNA synthetase 0.0031 0.0059 0.0234
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0163 0.0622 0.9738
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0255 0.3331
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0078 0.0259 0.1192
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0028 0.0043 0.0058
Echinococcus granulosus solute carrier family 22 0.0078 0.0259 0.0617
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0019 0.0061
Entamoeba histolytica protein kinase, putative 0.0171 0.0652 0.402
Trichomonas vaginalis sugar transporter, putative 0.0173 0.0661 0.2861
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0078 0.0256 0.1093
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0557 0.2299 0.5481
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0557 0.2299 0.5481
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0138
Mycobacterium tuberculosis Conserved protein 0.0077 0.0255 0.1172
Trypanosoma brucei THT1 - hexose transporter, putative 0.0173 0.0661 0.8747
Leishmania major myo-inositol/proton symporter (MIT) 0.0078 0.0259 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0078 0.0318
Giardia lamblia Glycyl-tRNA synthetase 0.0031 0.0059 0.0334
Mycobacterium leprae Probable lipase LipE 0.0077 0.0255 0.3564
Trypanosoma cruzi glucose transporter, putative 0.0078 0.0259 0.3384
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0163 0.0622 0.2689
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0117 0.0698
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Plasmodium vivax lysine--tRNA ligase, putative 0.0124 0.0455 0.045
Echinococcus multilocularis solute carrier family 22 0.0078 0.0259 0.0617
Toxoplasma gondii anticodon binding domain-containing protein 0.0019 0.0005 0.0001
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0085 0.0488
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.076 0.3291
Trypanosoma brucei glucose transporter 1E 0.0173 0.0661 0.8747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.0148
Echinococcus multilocularis pyruvate kinase 0.003 0.0051 0.0122
Schistosoma mansoni pyruvate kinase 0.0038 0.0085 0.035
Leishmania major glucose transporter, lmgt1 0.0173 0.0661 0.8747
Trichomonas vaginalis sugar transport protein, putative 0.0078 0.0259 0.1107
Leishmania major hypothetical protein, conserved 0.0079 0.0263 0.3434
Giardia lamblia Sugar-proton symporter 0.0078 0.0259 0.1578
Echinococcus granulosus lamin 0.0055 0.0159 0.038
Brugia malayi Major Facilitator Superfamily protein 0.0078 0.0259 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0043 0.0166
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0279 0.1197
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0031 0.0059 0.0716
Plasmodium falciparum calcium-dependent protein kinase 4 0.0171 0.0652 0.0648
Schistosoma mansoni intermediate filament proteins 0.0055 0.0159 0.0673
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0557 0.2299 0.5481
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0106 0.0375 0.5587
Brugia malayi beta-lactamase family protein 0.0077 0.0255 0.1089
Onchocerca volvulus 0.0078 0.0259 0.4043
Plasmodium vivax CDK-related protein kinase 6, putative 0.2365 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0117 0.0279
Entamoeba histolytica thioredoxin reductase, putative 0.0163 0.0622 0.3832
Trypanosoma brucei histidyl-tRNA synthetase 0.0019 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0255 0.1089
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0063 0.0151
Schistosoma mansoni glucose transport protein 0.0557 0.2299 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0135 0.05 0.1193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.076 0.1811
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0005 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0019 0.0185
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0041 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Schistosoma mansoni hypothetical protein 0.0557 0.2299 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0031 0.0059 0.0081
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0163 0.0619 0.9691
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0371 0.0885
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0085 0.035
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0085 0.0121
Treponema pallidum glycyl-tRNA synthetase 0.0019 0.0005 0.0003
Chlamydia trachomatis lysine--tRNA ligase 0.0124 0.0455 0.7296
Brugia malayi Sugar transporter family protein 0.0078 0.0259 0.1107
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0113 0.0406 0.249
Mycobacterium tuberculosis Conserved protein 0.0077 0.0255 0.1172
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0167 0.0637 0.2756
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Leishmania major DNA polymerase kappa, putative 0.0022 0.0019 0.0185
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0037 0.0087
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.0964
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0171 0.0652 0.1554
Echinococcus granulosus intermediate filament protein 0.0055 0.0159 0.038
Mycobacterium ulcerans sugar transporter 0.0078 0.0259 0.4117
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0041 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0054 0.0214
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0163 0.0619 0.9955
Echinococcus granulosus calcium dependent protein kinase 0.016 0.0607 0.1447
Brugia malayi hypothetical protein 0.0078 0.0259 0.1107
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0041 0.0158
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0124 0.0455 0.5997
Echinococcus multilocularis smad 0.0026 0.0037 0.0087
Treponema pallidum threonyl-tRNA synthetase 0.0031 0.0059 0.04
Loa Loa (eye worm) hypothetical protein 0.0077 0.0255 0.1089
Onchocerca volvulus 0.0077 0.0255 0.3961
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0255 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0661 0.2861
Loa Loa (eye worm) hypothetical protein 0.0124 0.0455 0.1962
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0019 0.0005 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0019 0.0186
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0041 0.0158
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0019 0.0061
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0063 0.0777
Trichomonas vaginalis sugar transporter, putative 0.0173 0.0661 0.2861
Leishmania major glycyl tRNA synthetase, putative 0.0019 0.0005 0.0005
Onchocerca volvulus 0.0078 0.0259 0.4043
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0063 0.0151
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0163 0.0619 0.2981
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0041 0.0225
Schistosoma mansoni transient receptor potential channel 0.0209 0.0814 0.3527
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0031 0.0059 0.014
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0163 0.0622 1
Schistosoma mansoni lamin 0.0055 0.0159 0.0673
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0124 0.0455 0.1962
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0163 0.0622 0.2689
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0043 0.0166
Loa Loa (eye worm) hypothetical protein 0.0136 0.0504 0.2174
Echinococcus multilocularis short transient receptor potential channel 6 0.0138 0.0513 0.1223
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0171 0.0652 0.1554
Brugia malayi hypothetical protein 0.0078 0.0259 0.1107
Plasmodium vivax threonine--tRNA ligase, putative 0.0031 0.0059 0.0054
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0106 0.0375 0.1769
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0016 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Schistosoma mansoni DNA polymerase eta 0.0022 0.0019 0.0061
Mycobacterium ulcerans beta-lactamase 0.0077 0.0255 0.4052
Entamoeba histolytica hypothetical protein 0.0075 0.0245 0.1489
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0171 0.0652 0.1554
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0019 0.0186
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.055 0.2376
Trypanosoma brucei glucose transporter, putative 0.0173 0.0661 0.8747
Echinococcus multilocularis tumor protein p63 0.1002 0.4194 1
Onchocerca volvulus 0.0078 0.0259 0.4043
Loa Loa (eye worm) sugar transporter 0.0557 0.2299 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0167 0.0637 0.2756
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0019 0.0185
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0031 0.0059 0.087
Leishmania major hypothetical protein, conserved 0.0077 0.0255 0.3331
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0135 0.05 0.1193
Onchocerca volvulus 0.0078 0.0259 0.4043
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0171 0.0652 0.0648
Brugia malayi beta-lactamase family protein 0.0077 0.0255 0.1089
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0076 0.0182
Echinococcus multilocularis synaptic vesicle 2 protein 0.0078 0.0259 0.0617
Schistosoma mansoni hypothetical protein 0.0135 0.05 0.2161
Brugia malayi Sugar transporter family protein 0.0078 0.0259 0.1107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0063 0.0151
Schistosoma mansoni sugar transporter 0.0078 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.035
Schistosoma mansoni sugar transporter 0.0078 0.0259 0.1107
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0085 0.035
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0019 0.0186
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0063 0.0254
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0037 0.0197
Trypanosoma brucei sugar transporter, putative 0.0078 0.0259 0.3384
Echinococcus multilocularis lamin 0.0055 0.0159 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.076 0.3291
Brugia malayi Smad1 0.0026 0.0037 0.0138
Brugia malayi Major Facilitator Superfamily protein 0.0078 0.0259 0.1107
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0031 0.0059 0.087
Schistosoma mansoni Smad4 0.0026 0.0037 0.0138
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0085 0.1069
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0063 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0117 0.049
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0171 0.0652 0.8623
Brugia malayi MH1 domain containing protein 0.0026 0.0037 0.0138
Schistosoma mansoni hypothetical protein 0.0075 0.0245 0.1045
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0028 0.0043 0.0508
Brugia malayi hypothetical protein 0.0051 0.0143 0.0602
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0037 0.0138
Plasmodium vivax proline--tRNA ligase, putative 0.0195 0.0755 0.0751
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0019 0.0005 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0078 0.0259 0.1107
Loa Loa (eye worm) Smad1 0.0026 0.0037 0.0138
Leishmania major threonyl-tRNA synthetase, putative 0.0031 0.0059 0.0715
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0041 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0019 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0275
Echinococcus granulosus solute carrier family 22 0.0078 0.0259 0.0617
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0019 0.0005 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.076 0.3291
Echinococcus granulosus Smad4 0.0026 0.0037 0.0087
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Brugia malayi hypothetical protein 0.0075 0.0245 0.1045
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0117 0.1498
Giardia lamblia Pyruvate kinase 0.0038 0.0085 0.0498
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0163 0.0622 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.076 0.3291
Toxoplasma gondii transporter, major facilitator family protein 0.0078 0.0259 0.0383
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0019 0.0005 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0275
Loa Loa (eye worm) hypothetical protein 0.0078 0.0259 0.1107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0171 0.0652 0.1554
Toxoplasma gondii glycyl-tRNA synthetase 0.0031 0.0059 0.0081
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0078 0.0975
Schistosoma mansoni lysyl-tRNA synthetase 0.0124 0.0455 0.1962
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.1345 0.5843
Echinococcus granulosus tumor protein p63 0.1002 0.4194 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0167 0.0637 0.2756
Leishmania major DNA polymerase eta, putative 0.0022 0.0019 0.0185
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0255 0.0607
Loa Loa (eye worm) hypothetical protein 0.0167 0.0637 0.2756
Brugia malayi major facilitator superfamily protein 0.0078 0.0259 0.1107
Echinococcus granulosus General substrate transporter 0.0479 0.1965 0.4685
Loa Loa (eye worm) sugar transporter 0.0078 0.0259 0.1107
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0061 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0043 0.0166
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0078 0.0259 0.1192
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0085 0.1069
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0171 0.0652 0.0977
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0255 0.1172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0427 0.1744 0.7581
Brugia malayi Bromodomain containing protein 0.0032 0.0061 0.0246
Schistosoma mansoni smad 0.0026 0.0037 0.0138
Schistosoma mansoni hypothetical protein 0.0292 0.1168 0.5072

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 26.1 % Antiedematogenic activity in Swiss mouse assessed as decrease of capsaicin-induced paw edema weight at 100 umol/kg, po administered 40 mins before capsaicin challenge measured after 30 mins relative to control ChEMBL. 20598893
Inhibition (functional) = 0 % Antiinflammatory activity against zymosan A-induced peritonitis in Swiss mouse assessed as inhibition of granulocyte infiltration in to peritoneal cavity at 100 mg/kg, po administered 40 mins before zymosan A challenge measured after 6 hrs relative to control ChEMBL. 20598893
Inhibition (functional) = 52.7 % Analgesic activity against formalin-induced acute pain in Swiss mouse assessed inhibition of nociception at 100 umol/kg, po administered 40 mins before formalin challenge measured for 15 to 30 mins relative to control ChEMBL. 20598893
Inhibition (functional) = 55.3 % Antiedematogenic activity in Swiss mouse assessed as inhibition of capsaicin-induced paw edema at 100 umol/kg, po administered 40 mins before capsaicin challenge measured after 30 mins relative to control ChEMBL. 20598893
Inhibition (functional) = 86.3 % Antinociceptive activity in Swiss mouse assessed as inhibition of acetic acid-induced abdominal constrictions at 100 umol/kg, po administered 40 mins before acetic acid challenge measured for 25 mins relative to control ChEMBL. 20598893
Time (functional) = 2.5 s Analgesic activity in Swiss mouse assessed as increase in latency of paw licking at 100 umol/kg, po after 60 mins measured for 60 seconds by hot plate test (Rvb = 4.9 +/- 0.5 seconds) ChEMBL. 20598893
Time (functional) = 3.5 s Analgesic activity in Swiss mouse assessed as increase in latency of paw licking at 100 umol/kg, po after 90 mins measured for 60 seconds by hot plate test (Rvb = 5.9 +/- 0.8 seconds) ChEMBL. 20598893
Time (functional) = 4.2 s Analgesic activity in Swiss mouse assessed as increase in latency of paw licking at 100 umol/kg, po after 150 mins measured for 60 seconds by hot plate test (Rvb = 5.1 +/- 0.4 seconds) ChEMBL. 20598893
Time (functional) = 6.2 s Analgesic activity in Swiss mouse assessed as increase in latency of paw licking at 100 umol/kg, po after 120 mins measured for 60 seconds by hot plate test (Rvb = 5.6 +/- 0.5 seconds) ChEMBL. 20598893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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