Detailed information for compound 1156934

Basic information

Technical information
  • TDR Targets ID: 1156934
  • Name: methyl 2-[3-(3-carbamimidoylphenyl)-5-[[4-(3- sulfamoylphenyl)phenyl]carbamoyl]-4H-1,2-oxaz ol-5-yl]acetate
  • MW: 535.572 | Formula: C26H25N5O6S
  • H donors: 3 H acceptors: 4 LogP: 1.52 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)CC1(ON=C(C1)c1cccc(c1)C(=N)N)C(=O)Nc1ccc(cc1)c1cccc(c1)S(=O)(=O)N
  • InChi: 1S/C26H25N5O6S/c1-36-23(32)15-26(14-22(31-37-26)18-5-2-6-19(12-18)24(27)28)25(33)30-20-10-8-16(9-11-20)17-4-3-7-21(13-17)38(29,34)35/h2-13H,14-15H2,1H3,(H3,27,28)(H,30,33)(H2,29,34,35)
  • InChiKey: DVZTUQJDBGWRKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[3-(3-carbamimidoylphenyl)-5-[[4-(3-sulfamoylphenyl)phenyl]carbamoyl]-4H-isoxazol-5-yl]acetate
  • 2-[3-(3-carbamimidoylphenyl)-5-[oxo-[[4-(3-sulfamoylphenyl)phenyl]amino]methyl]-4H-isoxazol-5-yl]acetic acid methyl ester
  • 2-[3-(3-amidinophenyl)-5-[[4-(3-sulfamoylphenyl)phenyl]carbamoyl]-4H-isoxazol-5-yl]acetic acid methyl ester
  • methyl 2-[3-(3-carbamimidoylphenyl)-5-[[4-(3-sulfamoylphenyl)phenyl]carbamoyl]-4H-1,2-oxazol-5-yl]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0046 0.0142
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0206 0.0632
Brugia malayi heat shock protein 90 0.031 0.1377 0.4298
Mycobacterium tuberculosis Conserved protein 0.0072 0.0245 0.1179
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0193 0.0821 0.8655
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0091 0.0339 0.1058
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0813 0.2499
Loa Loa (eye worm) bromodomain containing protein 0.0092 0.0342 0.1069
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0046 0.0144
Loa Loa (eye worm) hypothetical protein 0.0072 0.0245 0.0766
Schistosoma mansoni polycystin 1-related 0.0022 0.0007 0.0022
Mycobacterium ulcerans hypothetical protein 0.0072 0.0245 0.2603
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0089 0.0327 0.0327
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0245 0.0766
Leishmania major trypanothione reductase 0.0085 0.0306 0.0956
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0078 0.0563
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0042 0.0104 0.0744
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0044 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0372 0.1143
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0245 0.1782
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0626 0.0626
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0223 0.0965 0.6897
Mycobacterium ulcerans two component regulator - sensor kinase 0.0091 0.0339 0.3595
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0018 0.0128
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0034 0.0105
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0076 0.0076
Mycobacterium tuberculosis Probable dehydrogenase 0.0193 0.0821 0.3945
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0193 0.0821 0.3945
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0091 0.0339 0.0339
Leishmania major DNA topoisomerase ii 0.0091 0.0339 0.1058
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Treponema pallidum bacterioferrin (TpF1) 0.0028 0.0038 0.0401
Toxoplasma gondii DNA topoisomerase 2, putative 0.0091 0.0339 0.2422
Schistosoma mansoni hypothetical protein 0.0108 0.0416 0.1279
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0028 0.0038 0.0401
Mycobacterium tuberculosis Conserved protein 0.0091 0.0339 0.1628
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0242
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0245 0.0766
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0082 0.0256
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0369 0.1657 0.5172
Trypanosoma brucei ISWI complex protein 0.008 0.0284 0.0886
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0078 0.0563
Loa Loa (eye worm) TAR-binding protein 0.0191 0.0813 0.2537
Echinococcus multilocularis expressed protein 0.0028 0.0038 0.0038
Mycobacterium leprae Probable two component sensor kinase MprB 0.0091 0.0339 0.3327
Mycobacterium ulcerans lipase LipD 0.0072 0.0245 0.2603
Echinococcus granulosus sodium:myo inositol cotransporter 0.0042 0.0104 0.0104
Leishmania major mitochondrial DNA topoisomerase II 0.0091 0.0339 0.1058
Trichomonas vaginalis DNA topoisomerase II, putative 0.0091 0.0339 0.2461
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0091 0.0339 0.3595
Loa Loa (eye worm) hypothetical protein 0.0098 0.0369 0.1151
Echinococcus granulosus peregrin 0.0042 0.0105 0.0105
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0022 0.0158
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0091 0.0339 0.1058
Schistosoma mansoni intermediate filament proteins 0.0027 0.0034 0.0103
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0042 0.0104 0.0104
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Brugia malayi Muscleblind-like protein 0.0152 0.0626 0.1954
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0112 0.0439 0.3138
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0044 0.0137
Brugia malayi PHD-finger family protein 0.003 0.0046 0.0144
Schistosoma mansoni cellular tumor antigen P53 0.0311 0.1382 0.425
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Echinococcus multilocularis geminin 0.0173 0.0727 0.0727
Echinococcus granulosus geminin 0.0173 0.0727 0.0727
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0109 0.0793
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0091 0.0339 0.3595
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0164 0.0512
Loa Loa (eye worm) helicase 0.0036 0.0078 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0242
Plasmodium vivax heat shock protein 86, putative 0.031 0.1377 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0046 0.0046
Entamoeba histolytica Ran family GTPase 0.0022 0.0007 0.0052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0215 0.0923 0.4436
Schistosoma mansoni importin beta-1 0.0029 0.0044 0.0135
Schistosoma mansoni pyruvate dehydrogenase 0.0695 0.3203 0.985
Trichomonas vaginalis heat shock protein, putative 0.0112 0.0439 0.3187
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0091 0.0339 0.2461
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0022 0.0069
Echinococcus multilocularis musashi 0.0027 0.0034 0.0034
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0022 0.0161
Giardia lamblia Pms1-like protein 0.0091 0.0339 0.2461
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0048 0.0133 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0053 0.0162
Echinococcus multilocularis ferritin 0.0028 0.0038 0.0038
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0044 0.0319
Brugia malayi Sodium:solute symporter family protein 0.0042 0.0104 0.0325
Trypanosoma cruzi heat shock protein 90, putative 0.0198 0.0843 0.2631
Toxoplasma gondii Hsp90 domain-containing protein 0.0112 0.0439 0.3136
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0091 0.0339 0.1628
Echinococcus multilocularis snurportin 1 0.0313 0.1391 0.1391
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.0306 0.2225
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0046 0.033
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0044 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0078 0.0563
Onchocerca volvulus 0.0029 0.0044 0.0268
Trichomonas vaginalis chromobox protein, putative 0.0222 0.0961 0.6979
Loa Loa (eye worm) hypothetical protein 0.0152 0.0626 0.1954
Schistosoma mansoni pyruvate dehydrogenase 0.0603 0.2769 0.8515
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0188 0.0795 0.0795
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0092 0.067
Giardia lamblia Heat shock protein HSP 90-alpha 0.031 0.1377 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0626 0.1954
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0044 0.0466
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0044 0.0137
Plasmodium falciparum glutathione reductase 0.0029 0.0044 0.0319
Schistosoma mansoni bromodomain containing protein 0.0024 0.0019 0.0057
Loa Loa (eye worm) TOPoisomerase family member 0.0091 0.0339 0.1058
Loa Loa (eye worm) PHD-finger family protein 0.0108 0.0416 0.1298
Trichomonas vaginalis ran, putative 0.0022 0.0007 0.0052
Brugia malayi hypothetical protein 0.0036 0.0078 0.0242
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0022 0.0161
Loa Loa (eye worm) hypothetical protein 0.0224 0.0969 0.3025
Schistosoma mansoni sodium/solute symporter 0.0042 0.0104 0.032
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1057 0.7676
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0044 0.0466
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0022 0.0161
Toxoplasma gondii heat shock protein HSP90 0.031 0.1377 0.984
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0044 0.0211
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0019
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0119 0.0471 0.1449
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0044 0.0319
Loa Loa (eye worm) RNA binding protein 0.0191 0.0813 0.2537
Loa Loa (eye worm) hypothetical protein 0.0042 0.0104 0.0325
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0542 0.3934
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0007 0.0022
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0695 0.3203 0.3203
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0048 0.0133 0.0408
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0245 0.1782
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0027 0.0085
Loa Loa (eye worm) hypothetical protein 0.0072 0.0245 0.0766
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.0813 0.2537
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0137
Trypanosoma cruzi DNA topoisomerase II, putative 0.0091 0.0339 0.1058
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0078 0.0078
Schistosoma mansoni cpg binding protein 0.0041 0.0099 0.0305
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0091 0.0339 0.1058
Echinococcus granulosus fetal alzheimer antigen falz 0.0119 0.0471 0.0471
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0007 0.0052
Echinococcus multilocularis microtubule associated protein 2 0.0705 0.3252 0.3252
Trichomonas vaginalis receptor histidine kinase, putative 0.0091 0.0339 0.2461
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0497 0.3608
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0223 0.0965 0.3013
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.0306 0.0956
Leishmania major importin beta-1 subunit, putative 0.0024 0.0018 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0233 0.1662
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0134 0.0542 0.3887
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0006 0.0006
Toxoplasma gondii heat shock protein 75, putative 0.0112 0.0439 0.3136
Echinococcus multilocularis peregrin 0.0042 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0097
Loa Loa (eye worm) hypothetical protein 0.0072 0.0245 0.0766
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0053 0.0053
Entamoeba histolytica hypothetical protein 0.0036 0.0078 0.0563
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0109 0.0793
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0091 0.0339 0.3595
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0091 0.0339 0.2412
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0119 0.0471 0.0471
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0007 0.0022
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.0518 0.0518
Echinococcus multilocularis cpg binding protein 0.0041 0.0099 0.0099
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0368 0.0368
Echinococcus granulosus cpg binding protein 0.0041 0.0099 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0027 0.0085
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0091 0.0339 0.1628
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0497 0.3608
Loa Loa (eye worm) hypothetical protein 0.0072 0.0245 0.0766
Trypanosoma brucei heat shock protein 84, putative 0.0112 0.0439 0.137
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0022 0.0161
Mycobacterium ulcerans bacterioferritin BfrA 0.0028 0.0038 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0094 0.0686
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0078 0.0563
Echinococcus multilocularis chromobox protein 2 0.0036 0.0078 0.0078
Leishmania major hypothetical protein, conserved 0.0091 0.0339 0.1058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0109 0.0793
Brugia malayi follicle stimulating hormone receptor 0.0254 0.1109 0.3462
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0023
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0245 0.2603
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0309 0.0309
Echinococcus granulosus microtubule associated protein 2 0.0705 0.3252 0.3252
Echinococcus granulosus ferritin 0.0028 0.0038 0.0038
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0112 0.0439 0.0439
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Echinococcus granulosus chromobox protein 1 0.0222 0.0961 0.0961
Schistosoma mansoni chromobox protein 0.0036 0.0078 0.0238
Brugia malayi PHD-finger family protein 0.0132 0.053 0.1654
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0091 0.0339 0.1058
Brugia malayi beta-lactamase family protein 0.0072 0.0245 0.0766
Brugia malayi hypothetical protein 0.0022 0.0007 0.0023
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0044 0.0135
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0046 0.0144
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0215 0.0923 0.4436
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0245 0.0766
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0091 0.0339 0.2461
Plasmodium vivax heat shock protein 90, putative 0.0112 0.0439 0.3187
Echinococcus granulosus snurportin 1 0.0313 0.1391 0.1391
Loa Loa (eye worm) hypothetical protein 0.0091 0.0339 0.1058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0372 0.0372
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0313 0.1392 0.1392
Plasmodium vivax SET domain protein, putative 0.0031 0.0053 0.0382
Trichomonas vaginalis chromobox protein, putative 0.0222 0.0961 0.6979
Plasmodium vivax endoplasmin, putative 0.031 0.1377 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0245 0.0766
Leishmania major heat shock protein, putative 0.0112 0.0439 0.137
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0044 0.0044
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0007 0.0052
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0078 0.0554
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0007 0.0052
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0219 0.0943 0.2943
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0091 0.0339 0.3595
Mycobacterium tuberculosis Possible two component sensor kinase 0.0091 0.0339 0.1628
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0091 0.0339 0.1628
Mycobacterium ulcerans beta-lactamase 0.0072 0.0245 0.2603
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Plasmodium falciparum heat shock protein 90, putative 0.0112 0.0439 0.3187
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.02 0.0855 0.267
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0022 0.0161
Brugia malayi jmjC domain containing protein 0.0048 0.0131 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0372 0.0372
Schistosoma mansoni pyruvate dehydrogenase 0.0603 0.2769 0.8515
Schistosoma mansoni microtubule-associated protein tau 0.0705 0.3252 1
Trypanosoma cruzi Heat shock protein 83, putative 0.031 0.1377 0.4298
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Plasmodium falciparum DNA topoisomerase 2 0.0091 0.0339 0.2461
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0245 0.1179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0078 0.0563
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0245 0.1179
Chlamydia trachomatis DNA gyrase subunit B 0.0091 0.0339 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0022 0.0068
Schistosoma mansoni hypothetical protein 0.0036 0.0078 0.0238
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.1109 0.3462
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0078 0.0563
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0372 0.0372
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0542 0.3934
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0048 0.0133 0.0133
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0028 0.0038 0.0182
Leishmania major hypothetical protein, conserved 0.0072 0.0245 0.0766
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0022 0.0069
Brugia malayi intermediate filament protein 0.0027 0.0034 0.0105
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0695 0.3203 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0007 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0044 0.0319
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0197 0.0614
Loa Loa (eye worm) hypothetical protein 0.0051 0.0147 0.0459
Brugia malayi Bromodomain containing protein 0.0042 0.0105 0.0327
Trichomonas vaginalis heat shock protein, putative 0.031 0.1377 1
Loa Loa (eye worm) heat shock protein 90 0.031 0.1377 0.4298
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Mycobacterium ulcerans two component sensor kinase MprB 0.0091 0.0339 0.3595
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Echinococcus granulosus sodium:glucose cotransporter 0.0042 0.0104 0.0104
Trichomonas vaginalis ferritin, putative 0.0028 0.0038 0.0275
Echinococcus granulosus zinc finger protein 0.0104 0.0398 0.0398
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0078 0.0078
Trichomonas vaginalis sensor histidine kinase, putative 0.0091 0.0339 0.2461
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Schistosoma mansoni zinc finger protein 0.008 0.0284 0.0872
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0018 0.0128
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0044 0.0314
Schistosoma mansoni ferritin light chain 0.0028 0.0038 0.0116
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0091 0.0339 0.3595
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0078 0.0238
Plasmodium falciparum heat shock protein 90 0.031 0.1377 1
Trypanosoma cruzi heat shock protein 90, putative 0.031 0.1377 0.4298
Echinococcus granulosus heat shock protein 0.031 0.1377 0.1377
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0007 0.0022
Trichomonas vaginalis endoplasmin, putative 0.0204 0.0873 0.634
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0018 0.0128
Loa Loa (eye worm) hypothetical protein 0.012 0.0475 0.1483
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0027 0.0085
Echinococcus granulosus importin subunit beta 1 0.0029 0.0044 0.0044
Brugia malayi Importin beta-1 subunit 0.0029 0.0044 0.0137
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0091 0.0339 0.3595
Onchocerca volvulus 0.0072 0.0245 0.1732
Leishmania major hypothetical protein, conserved 0.0026 0.0027 0.0085
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0022 0.0068
Plasmodium vivax DNA topoisomerase II, putative 0.0091 0.0339 0.2461
Echinococcus multilocularis high affinity choline transporter 1 0.0381 0.1712 0.1712
Loa Loa (eye worm) hypothetical protein 0.0055 0.0164 0.0512
Plasmodium vivax glutathione reductase, putative 0.0085 0.0306 0.2225
Brugia malayi GH02984p 0.0381 0.1712 0.5344
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0105
Mycobacterium tuberculosis Probable oxidoreductase 0.0215 0.0923 0.4436
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0044 0.0466
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0078 0.0242
Treponema pallidum heat shock protein 90 0.0219 0.0943 1
Schistosoma mansoni apoferritin-2 0.0028 0.0038 0.0116
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0044 0.0137
Echinococcus multilocularis lamin 0.0027 0.0034 0.0034
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0091 0.0339 0.1628
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0089 0.0327 0.1006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0193 0.0821 0.3945
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.0078 0.0563
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0007 0.0022
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0695 0.3203 0.3203
Plasmodium falciparum thioredoxin reductase 0.0029 0.0044 0.0319
Trichomonas vaginalis heat shock protein, putative 0.0204 0.0873 0.634
Brugia malayi Probable DNA topoisomerase II 0.0091 0.0339 0.1058
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0007 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.031 0.1377 0.4298
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0695 0.3203 1
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0813 0.2499
Loa Loa (eye worm) CHromoDomain protein family member 0.0048 0.0133 0.0415
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0245 0.1179
Chlamydia trachomatis DNA gyrase subunit B 0.0091 0.0339 1
Brugia malayi RNA binding protein 0.0191 0.0813 0.2537
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0917 0.2864
Trypanosoma brucei trypanothione reductase 0.0085 0.0306 0.0956
Plasmodium falciparum DNA gyrase subunit B 0.0091 0.0339 0.2461
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0027 0.0197
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0078 0.0242
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0078 0.0563
Plasmodium vivax hypothetical protein, conserved 0.003 0.0046 0.0335
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0022 0.0069
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0078 0.0563
Echinococcus multilocularis endoplasmin 0.0219 0.0943 0.0943
Schistosoma mansoni zinc finger protein 0.0104 0.0398 0.1223
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0044 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0131 0.0403
Trypanosoma cruzi heat shock protein 85, putative 0.031 0.1377 0.4298
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0091 0.0339 0.1058
Plasmodium falciparum endoplasmin, putative 0.0204 0.0873 0.634
Brugia malayi hypothetical protein 0.0022 0.0007 0.0023
Loa Loa (eye worm) heterochromatin protein 1 0.0222 0.0961 0.2999
Echinococcus multilocularis chromobox protein 1 0.0222 0.0961 0.0961
Echinococcus granulosus solute carrier family 5 0.0042 0.0104 0.0104
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0018 0.0055
Onchocerca volvulus 0.0072 0.0245 0.1732
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0044 0.0319
Schistosoma mansoni lamin 0.0027 0.0034 0.0103
Loa Loa (eye worm) hypothetical protein 0.0091 0.0339 0.1058
Echinococcus multilocularis heat shock protein 90 0.031 0.1377 0.1377
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0072 0.0245 0.0766
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0091 0.0339 0.1628
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0007 0.0007
Onchocerca volvulus 0.0042 0.0104 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Loa Loa (eye worm) hypothetical protein 0.0072 0.0245 0.0766
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0044 0.0044
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0053 0.0376
Brugia malayi Heterochromatin protein 1 0.0222 0.0961 0.2999
Loa Loa (eye worm) hypothetical protein 0.0311 0.1382 0.4315
Schistosoma mansoni ferritin 0.0028 0.0038 0.0116
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0044 0.0319
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0078 0.0563
Brugia malayi SET domain containing protein 0.0038 0.0086 0.0268
Echinococcus granulosus heat shock protein 90 0.031 0.1377 0.1377
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0044 0.0137
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0188 0.0795 0.0795
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.1391 0.4342
Onchocerca volvulus 0.0098 0.0369 0.263
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0007 0.0007
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0695 0.3203 0.3203
Toxoplasma gondii ABC1 family protein 0.0072 0.0245 0.1753
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0273 0.0838
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0007 0.0051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0044 0.0466
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.1889 0.1889
Schistosoma mansoni hypothetical protein 0.0022 0.0007 0.0022
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0007 0.0007
Trypanosoma cruzi heat shock protein 85, putative 0.0219 0.0943 0.2943
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.0306 0.0956
Giardia lamblia Grp94/Hsp90 0.0219 0.0943 0.6847
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0042 0.0104 0.0104
Giardia lamblia Heat shock protein HSP 90-alpha 0.0219 0.0943 0.6847
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0091 0.0339 0.1058
Trypanosoma cruzi heat shock protein 90, putative 0.0219 0.0943 0.2943
Echinococcus multilocularis tumor protein p63 0.2126 1 1
Loa Loa (eye worm) heat shock protein 75 0.0112 0.0439 0.137
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Echinococcus multilocularis chromobox protein 1 0.0222 0.0961 0.0961
Plasmodium falciparum phd finger protein, putative 0.003 0.0046 0.0335
Onchocerca volvulus 0.0027 0.0034 0.0191
Brugia malayi Pre-SET motif family protein 0.0031 0.0053 0.0164
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0475 0.0475
Schistosoma mansoni hypothetical protein 0.008 0.0284 0.0872
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0219 0.0943 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0091 0.0339 0.2412
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0044 0.0137
Schistosoma mansoni ran 0.0022 0.0007 0.0022
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0082 0.0256
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0102 0.0102
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0091 0.0339 0.1628
Loa Loa (eye worm) hypothetical protein 0.0125 0.0497 0.1551
Plasmodium vivax DNA gyrase subunit B, putative 0.0091 0.0339 0.2461
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0022 0.0069
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0219 0.0943 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0091 0.0339 0.1058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0245 0.0754
Schistosoma mansoni lipoxygenase 0.009 0.0333 0.1025
Echinococcus granulosus chromobox protein 1 0.0222 0.0961 0.0961
Onchocerca volvulus 0.0036 0.0078 0.0512
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0242
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Echinococcus granulosus sodium:glucose cotransporter 2 0.0042 0.0104 0.0104
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Onchocerca volvulus Alhambra homolog 0.003 0.0046 0.0283
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0022 0.0069
Treponema pallidum NADH oxidase 0.0029 0.0044 0.0466
Entamoeba histolytica hypothetical protein 0.0036 0.0078 0.0563
Leishmania major developmentally regulated phosphoprotein-like protein 0.0695 0.3203 1
Schistosoma mansoni lipoxygenase 0.0129 0.0518 0.1593
Entamoeba histolytica hypothetical protein 0.0036 0.0078 0.0563
Brugia malayi glutathione reductase 0.0085 0.0306 0.0956
Echinococcus granulosus methyl CpG binding domain protein 2 0.0089 0.0327 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0372 0.1143
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0091 0.0339 0.2412
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0044 0.0466
Brugia malayi PHD-finger family protein 0.0021 0.0006 0.0019
Echinococcus multilocularis heat shock protein 90 0.0219 0.0943 0.0943
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0094 0.0686
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0888 0.4121 0.4121
Echinococcus multilocularis RUN 0.0022 0.0007 0.0007
Schistosoma mansoni endoplasmin 0.031 0.1377 0.4234
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0091 0.0339 0.1628
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0109 0.0793
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0372 0.116
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.0497 0.356
Brugia malayi beta-lactamase 0.0072 0.0245 0.0766
Leishmania major GTP-binding protein, putative 0.0022 0.0007 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0044 0.0137
Trichomonas vaginalis Heterochromatin protein, putative 0.0036 0.0078 0.0563
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0007 0.0052
Echinococcus multilocularis zinc finger protein 0.0104 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0242
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0007 0.0007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0313 0.1392 0.1392
Echinococcus granulosus muscleblind protein 0.0152 0.0626 0.0626
Trichomonas vaginalis heat shock protein, putative 0.0219 0.0943 0.6847
Brugia malayi Hsp90 protein 0.0112 0.0439 0.137
Schistosoma mansoni ferritin light chain 0.0028 0.0038 0.0116
Trichomonas vaginalis receptor histidine kinase, putative 0.0091 0.0339 0.2461
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0245 0.1782
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0109 0.0793
Schistosoma mansoni chromobox protein 0.0222 0.0961 0.2954
Brugia malayi chromobox protein homolog 3 0.0125 0.0497 0.1551
Echinococcus granulosus lamin dm0 0.0027 0.0034 0.0034
Schistosoma mansoni loxhd1 0.0022 0.0007 0.0022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0193 0.0821 0.3945
Loa Loa (eye worm) beta-lactamase 0.0072 0.0245 0.0766
Mycobacterium ulcerans putative regultory protein 0.0091 0.0339 0.3595
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0091 0.0339 0.2461
Echinococcus multilocularis muscleblind protein 0.0152 0.0626 0.0626
Onchocerca volvulus 0.0072 0.0245 0.1732
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0245 0.1782
Onchocerca volvulus 0.0068 0.0225 0.1587
Entamoeba histolytica heat shock protein 90, putative 0.031 0.1377 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0007 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0245 0.2603
Schistosoma mansoni heat shock protein 0.031 0.1377 0.4234
Schistosoma mansoni chromobox protein 0.0222 0.0961 0.2954
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Schistosoma mansoni ferritin 0.0028 0.0038 0.0116
Brugia malayi beta-lactamase family protein 0.0072 0.0245 0.0766
Loa Loa (eye worm) hypothetical protein 0.0381 0.1712 0.5344
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0144
Trypanosoma brucei developmentally regulated phosphoprotein 0.0695 0.3203 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0091 0.0339 0.3595
Brugia malayi Pre-SET motif family protein 0.0213 0.0917 0.2864
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0091 0.0339 0.3595
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0245 0.0766
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0813 0.2499
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0091 0.0339 0.3327
Echinococcus granulosus heat shock protein 90 0.0219 0.0943 0.0943
Brugia malayi TAR-binding protein 0.0191 0.0813 0.2537
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0078 0.0563
Mycobacterium tuberculosis Probable reductase 0.0193 0.0821 0.3945
Echinococcus multilocularis solute carrier family 5 0.0042 0.0104 0.0104
Brugia malayi Doublecortin family protein 0.0022 0.0007 0.0023
Entamoeba histolytica hypothetical protein 0.0024 0.0018 0.0128
Plasmodium falciparum heterochromatin protein 1 0.0036 0.0078 0.0563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0475 0.1461
Mycobacterium leprae Probable lipase LipE 0.0072 0.0245 0.2294
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0475 0.1461
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0034 0.0105
Brugia malayi jmjC domain containing protein 0.0098 0.0368 0.1148
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0091 0.0339 0.2461
Echinococcus granulosus expressed protein 0.0028 0.0038 0.0038
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0027 0.0193
Trypanosoma cruzi heat shock protein 85, putative 0.031 0.1377 0.4298
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0368 0.0368
Echinococcus granulosus tar DNA binding protein 0.0191 0.0813 0.0813
Brugia malayi kinase, mitochondrial precursor 0.0695 0.3203 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0078 0.0563
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0078 0.0238
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0173 0.0727 0.2234
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0245 0.1179
Giardia lamblia PHD finger protein 15 0.003 0.0046 0.0335
Echinococcus granulosus dnaJ subfamily B 0.0418 0.1889 0.1889
Echinococcus granulosus high affinity choline transporter 1 0.0381 0.1712 0.1712
Schistosoma mansoni hypothetical protein 0.0173 0.0727 0.2234
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0193 0.0821 0.3945
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0215 0.0923 0.9785
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.0813 0.2537
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0044 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0109 0.0793
Toxoplasma gondii heat shock protein 90, putative 0.031 0.1377 0.984
Loa Loa (eye worm) endoplasmin 0.031 0.1377 0.4298
Schistosoma mansoni rab6-interacting 0.0022 0.0007 0.0022
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0078 0.0554
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0068 0.0225 0.0693
Onchocerca volvulus 0.0311 0.1382 1
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0078 0.0563
Plasmodium falciparum heat shock protein 90, putative 0.0112 0.0439 0.3187
Schistosoma mansoni bromodomain containing protein 0.0332 0.148 0.4552
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0044 0.0314
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0044 0.0319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0372 0.0372
Onchocerca volvulus 0.0243 0.1057 0.7633
Trypanosoma cruzi heat shock protein, putative 0.0112 0.0439 0.137
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0022 0.0068
Onchocerca volvulus 0.0036 0.0078 0.0512
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0164 0.0512
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0245 0.1782
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0042 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0242
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0044 0.0137
Schistosoma mansoni inositol transporter 0.0042 0.0104 0.032
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0027 0.0197
Brugia malayi Protein cec-1. 0.0036 0.0078 0.0242
Plasmodium vivax heat shock protein, putative 0.0112 0.0439 0.3187
Schistosoma mansoni apoferritin-2 0.0028 0.0038 0.0116
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0091 0.0339 0.2461
Schistosoma mansoni chromobox protein 0.0036 0.0078 0.0238
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0091 0.0339 0.2422
Schistosoma mansoni hypothetical protein 0.0418 0.1889 0.5808
Echinococcus multilocularis tar DNA binding protein 0.0191 0.0813 0.0813
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0091 0.0339 0.1628
Schistosoma mansoni hypothetical protein 0.003 0.0046 0.0142
Echinococcus multilocularis heat shock protein 0.031 0.1377 0.1377
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0091 0.0339 0.3595
Mycobacterium leprae Probable two-component sensor kinase 0.0091 0.0339 0.3327
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0219 0.0943 0.0943
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0813 0.2499
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0475 0.0475
Plasmodium vivax importin-beta 2, putative 0.0029 0.0044 0.0319
Schistosoma mansoni cpg binding protein 0.0029 0.0044 0.0135
Echinococcus granulosus Chromobox protein 3 0.0036 0.0078 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0109 0.0793
Loa Loa (eye worm) glutathione reductase 0.0085 0.0306 0.0956
Schistosoma mansoni DNA topoisomerase II 0.0091 0.0339 0.1042
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0091 0.0339 0.3595
Schistosoma mansoni methyl-cpg binding protein mbd 0.0089 0.0327 0.1006
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0028 0.0038 0.0182
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0078 0.0554
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0091 0.0339 0.1628
Trichomonas vaginalis hypothetical protein 0.0036 0.0078 0.0563
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Mycobacterium tuberculosis Probable two component sensor kinase 0.0091 0.0339 0.1628
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0022 0.0069
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Onchocerca volvulus 0.0027 0.0034 0.0191
Mycobacterium tuberculosis Conserved protein 0.0072 0.0245 0.1179
Trypanosoma brucei heat shock protein 90, putative 0.031 0.1377 0.4298
Trichomonas vaginalis esterase, putative 0.0072 0.0245 0.1782
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0006 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0372 0.116
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0078 0.0242
Brugia malayi hypothetical protein 0.0026 0.0027 0.0085
Schistosoma mansoni endoplasmin 0.031 0.1377 0.4234
Trypanosoma cruzi ISWI complex protein 0.008 0.0284 0.0886
Trichomonas vaginalis chaperonin, putative 0.0025 0.0022 0.0161
Plasmodium falciparum importin beta, putative 0.0029 0.0044 0.0319
Schistosoma mansoni high-affinity choline transporter 0.0381 0.1712 0.5264
Trypanosoma brucei DNA topoisomerase ii 0.0091 0.0339 0.1058
Schistosoma mansoni cpg binding protein 0.0041 0.0099 0.0305
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0044 0.0137
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0245 0.2294
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0109 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.2081 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0044 0.0044
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0091 0.0339 0.1058
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0339 0.2461
Schistosoma mansoni ferritin 0.0028 0.0038 0.0116
Schistosoma mansoni rab6-interacting 0.0022 0.0007 0.0022
Schistosoma mansoni ferritin 0.0028 0.0038 0.0116
Trichomonas vaginalis heat shock protein, putative 0.0219 0.0943 0.6847
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0091 0.0339 0.2422
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0078 0.0238
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0219 0.0943 0.4529
Schistosoma mansoni hypothetical protein 0.0313 0.1391 0.4276
Brugia malayi Bromodomain containing protein 0.02 0.0854 0.2664
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0324 0.2352
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0044 0.0137
Mycobacterium ulcerans DNA gyrase subunit B 0.0091 0.0339 0.3595
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0102 0.0102
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0245 0.0245
Echinococcus granulosus lamin 0.0027 0.0034 0.0034
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0042 0.0104 0.0104
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0245 0.1179
Brugia malayi CHD4 protein 0.0048 0.0133 0.0415
Schistosoma mansoni ran 0.0022 0.0007 0.0022
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0091 0.0339 0.2461
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0223 0.0965 0.3013
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0044 0.0314
Echinococcus multilocularis lamin dm0 0.0027 0.0034 0.0034
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0091 0.0339 0.0339
Trypanosoma brucei heat shock protein 90, putative 0.031 0.1377 0.4298
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0034 0.0105
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0242
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0223 0.0965 0.3013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0058
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0046 0.0046
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Leishmania major hypothetical protein, conserved 0.008 0.0284 0.0886
Schistosoma mansoni lamin 0.0027 0.0034 0.0103
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0245 0.1179
Echinococcus granulosus Chromo domain 0.0036 0.0078 0.0078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0245 0.0754
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0007 0.0052
Plasmodium falciparum glutathione reductase 0.0085 0.0306 0.2225
Trichomonas vaginalis heat shock protein, putative 0.0219 0.0943 0.6847
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0813 0.2499
Schistosoma mansoni inositol transporter 0.0042 0.0104 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0078 0.0563
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0091 0.0339 0.1628
Brugia malayi CXXC zinc finger family protein 0.0029 0.0044 0.0137
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.0306 0.1472
Brugia malayi Thioredoxin reductase 0.0085 0.0306 0.0956
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0131 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0324 0.2352
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0372 0.1143
Echinococcus granulosus intermediate filament protein 0.0027 0.0034 0.0034
Mycobacterium tuberculosis Conserved protein 0.0072 0.0245 0.1179
Brugia malayi Bromodomain containing protein 0.0393 0.1771 0.5527
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0091 0.0339 0.3595
Trypanosoma brucei heat shock protein, putative 0.031 0.1377 0.4298
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0091 0.0339 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0091 0.0339 0.1058
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0245 0.1782
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0131 0.0403
Schistosoma mansoni hypothetical protein 0.0037 0.0082 0.0252
Echinococcus multilocularis Chromo domain 0.0036 0.0078 0.0078
Trypanosoma cruzi ISWI complex protein 0.008 0.0284 0.0886
Loa Loa (eye worm) hypothetical protein 0.0213 0.0914 0.2853
Echinococcus granulosus lysine specific demethylase 5A 0.0048 0.0131 0.0131
Mycobacterium ulcerans bacterioferritin BfrB 0.0028 0.0038 0.0401
Entamoeba histolytica heat shock protein 90, putative 0.031 0.1377 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0091 0.0339 0.1628
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0027 0.0197
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0078 0.0078
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0112 0.0439 0.3187
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0091 0.0339 0.3327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Entamoeba histolytica DNA topoisomerase II, putative 0.0091 0.0339 0.2461
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0091 0.0339 0.3595
Echinococcus granulosus RUN 0.0022 0.0007 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0164 0.0512
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0091 0.0339 0.3595
Plasmodium falciparum thioredoxin reductase 0.0085 0.0306 0.2225
Leishmania major heat shock protein 83-1 0.031 0.1377 0.4298
Mycobacterium ulcerans heat shock protein 90 0.0219 0.0943 1
Schistosoma mansoni heat shock protein 0.0112 0.0439 0.1349
Brugia malayi Endoplasmin precursor 0.031 0.1377 0.4298
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0315 0.1399 1
Echinococcus granulosus endoplasmin 0.0219 0.0943 0.0943
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0046 0.033
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.0078 0.0242
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0044 0.0319
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0112 0.0439 0.0439
Toxoplasma gondii thioredoxin reductase 0.0085 0.0306 0.219
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.0518 0.0518
Schistosoma mansoni heat shock protein 0.031 0.1377 0.4234
Echinococcus granulosus chromobox protein 2 0.0036 0.0078 0.0078
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0078 0.0563
Brugia malayi RNA, U transporter 1 0.0083 0.0301 0.0938
Trypanosoma brucei Heat shock protein 83, putative 0.031 0.1377 0.4298
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0044 0.0137
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0245 0.1179

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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