Detailed information for compound 1165629

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 279.129 | Formula: C13H11BrO2
  • H donors: 2 H acceptors: 2 LogP: 3.82 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cc(O)c(cc1Cc1ccccc1)O
  • InChi: 1S/C13H11BrO2/c14-11-8-13(16)12(15)7-10(11)6-9-4-2-1-3-5-9/h1-5,7-8,15-16H,6H2
  • InChiKey: OMELPYQOXGTQNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable reductase 0.0125 0.0141 0.8646
Leishmania major sterol C-24 reductase, putative 0.0047 0.0042 0.0051
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.0312 0.0312
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0007 0.0006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0162 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0007 0.0006
Schistosoma mansoni opsin-like receptor 0.002 0.0007 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.001 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0058 0.0056
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0052 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0008 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0007 0.0006
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0006 0.0539
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0008 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Onchocerca volvulus 0.0511 0.0628 0.0621
Echinococcus granulosus jumonji domain containing protein 0.004 0.0033 0.0032
Onchocerca volvulus 0.0064 0.0064 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0008 0.0007
Plasmodium vivax glutathione reductase, putative 0.0055 0.0052 0.8032
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0199 0.3092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0008 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0033 0.0429
Echinococcus multilocularis geminin 0.039 0.0476 0.0475
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0007 0.0006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Chlamydia trachomatis glycogen phosphorylase 0.0319 0.0386 1
Schistosoma mansoni hypothetical protein 0.039 0.0476 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0019 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.0312 0.0311
Echinococcus granulosus vesicular acetylcholine transporter 0.7921 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0007 0.0006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.2186
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0019 0.2616
Loa Loa (eye worm) hypothetical protein 0.0158 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0007 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.001 0.0242
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0007 0.0006
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0058 0.0056
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0007 0.0007
Treponema pallidum sodium- and chloride- dependent transporter 0.0158 0.0182 0.5107
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.001 0.0009
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0016 0.2155
Leishmania major DNA polymerase kappa, putative 0.0022 0.001 0.0005
Echinococcus granulosus neuropeptide receptor 0.002 0.0007 0.0006
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0007 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0027 0.0026
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0078 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0052 0.0052
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0007 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0033 0.4945
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0064 0.0063
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0007 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0064 0.0063
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0007 0.0006
Schistosoma mansoni neuropeptide receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Leishmania major trypanothione reductase 0.0055 0.0052 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0199 0.3092
Echinococcus granulosus g protein coupled receptor 0.002 0.0007 0.0006
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0013 0.0108
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0007 0.0006
Plasmodium falciparum thioredoxin reductase 0.0055 0.0052 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0007 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Brugia malayi PHD-finger family protein 0.0029 0.0019 0.0019
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.001 0.006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0042 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0007 0.0006
Brugia malayi G protein-coupled receptor 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0007 0.0006
Brugia malayi carbohydrate phosphorylase 0.0319 0.0386 0.0386
Brugia malayi RNA recognition motif domain containing protein 0.0059 0.0058 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) glycogen phosphorylase 0.0319 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.027 0.0323 0.0322
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0033 0.0777
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0007 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.001 0.0242
Schistosoma mansoni hypothetical protein 0.039 0.0476 0.0475
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0033 0.0429
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Entamoeba histolytica glycogenphosphorylase, putative 0.0138 0.0157 0.3904
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0008 0.0008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0033 0.061
Toxoplasma gondii exonuclease III APE 0.004 0.0033 0.4966
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0064 0.0063
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0581 0.0717 0.0716
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0027 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0006 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.001 0.006
Plasmodium falciparum phd finger protein, putative 0.0029 0.0019 0.2772
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0158 0.0182 0.0181
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0007 0.0006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0007 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0007 0.0006
Brugia malayi jmjC domain containing protein 0.0095 0.0102 0.0102
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0007 0.0006
Echinococcus multilocularis dna polymerase eta 0.0022 0.001 0.0009
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0007 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0008 0.0007
Giardia lamblia Glycogen phosphorylase 0.0319 0.0386 1
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0312 0.4915
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0007 0.0006
Schistosoma mansoni opsin-like receptor 0.002 0.0007 0.0006
Echinococcus multilocularis vesicular acetylcholine transporter 0.7921 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0008 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0007 0.0006
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0007 0.0006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0052 0.292
Schistosoma mansoni nuclear hormone receptor 0.002 0.0008 0.0007
Brugia malayi putative neuropeptide receptor 0.002 0.0007 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0033 0.0703
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0016 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0199 0.3092
Schistosoma mansoni amine GPCR 0.002 0.0007 0.0006
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0008 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.0041 0.0041
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0007 0.0006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.001 0.0242
Brugia malayi Dopamine receptor protein 1 0.002 0.0007 0.0007
Loa Loa (eye worm) TAR-binding protein 0.0059 0.0058 0.0056
Echinococcus multilocularis fmrfamide receptor 0.002 0.0007 0.0006
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0007 0.0006
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0007 0.0006
Onchocerca volvulus 0.0027 0.0016 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0008 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.001 0.0012
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0007 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0033 0.0038
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0007 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.035 0.9042
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0058 0.0056
Onchocerca volvulus 0.0027 0.0016 0.0009
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.001 0.0242
Brugia malayi steroid hormone receptor 0.002 0.0008 0.0008
Trypanosoma cruzi sterol C-24 reductase, putative 0.0047 0.0042 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0141 0.8646
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0008 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0102 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Schistosoma mansoni thyroid hormone receptor 0.002 0.0008 0.0007
Echinococcus multilocularis serotonin receptor 0.002 0.0007 0.0006
Echinococcus multilocularis allatostatin A receptor 0.002 0.0007 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0061 0.006
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0007 0.0007
Trypanosoma brucei trypanothione reductase 0.0055 0.0052 0.0072
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0007 0.0006
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0007 0.0007
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.0016 0.0258
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0008 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0006 0.0007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0006 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0013 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Brugia malayi AKH receptor 0.002 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0008 0.0008
Trypanosoma cruzi C-14 sterol reductase, putative 0.0091 0.0097 0.013
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0007 0.0006
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0016 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0008 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0007 0.0006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Echinococcus granulosus glycogen phosphorylase 0.0319 0.0386 0.0385
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0158 0.0182 0.0175
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.001 0.0009
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.7921 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Schistosoma mansoni neuropeptide receptor 0.002 0.0007 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0019 0.2646
Echinococcus multilocularis synaptic vesicular amine transporter 0.0581 0.0717 0.0716
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0027 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0006 0.0578
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0058 0.0056
Echinococcus granulosus serotonin receptor 0.002 0.0007 0.0006
Echinococcus granulosus tar DNA binding protein 0.0059 0.0058 0.0056
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0138 0.0157 0.9684
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0312 0.4915
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0033 0.0045
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Brugia malayi Dopamine receptor protein 2 0.002 0.0007 0.0007
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0159 0.9783
Trichomonas vaginalis set domain proteins, putative 0.0511 0.0628 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0182 0.0181
Schistosoma mansoni hypothetical protein 0.0055 0.0052 0.0051
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0007 0.0006
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0008 0.0008
Entamoeba histolytica glycogen phosphorylase, putative 0.0138 0.0157 0.3904
Echinococcus granulosus lamin b receptor 0.0091 0.0097 0.0096
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.001 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.001 0.001
Brugia malayi follicle stimulating hormone receptor 0.0282 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.001 0.001
Echinococcus granulosus dna polymerase eta 0.0022 0.001 0.0009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.035 0.9033
Leishmania major DNA polymerase eta, putative 0.0022 0.001 0.0005
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0006
Plasmodium vivax amine transporter, putative 0.0027 0.0016 0.2154
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Echinococcus granulosus somatostatin receptor 0.002 0.0007 0.0006
Onchocerca volvulus Alhambra homolog 0.0029 0.0019 0.0012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0008 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0007 0.0006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0007 0.0006
Echinococcus granulosus geminin 0.039 0.0476 0.0475
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0312 0.4915
Brugia malayi RNA binding protein 0.0059 0.0058 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.001 0.0005
Brugia malayi Pre-SET motif family protein 0.0449 0.055 0.055
Giardia lamblia DINP protein human, muc B family 0.0022 0.001 0.0099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0008 0.0007
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0007 0.0006
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0007 0.0007
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0007 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0159 0.9783
Onchocerca volvulus 0.0027 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus Glycosyl transferase family 35 0.0319 0.0386 0.0385
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0007 0.0006
Schistosoma mansoni DNA polymerase eta 0.0022 0.001 0.0009
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0007 0.0006
Schistosoma mansoni thyroid hormone receptor 0.002 0.0008 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.001 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0008 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Entamoeba histolytica glycogen phosphorylase, putative 0.0138 0.0157 0.3904
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0007 0.0006
Trypanosoma cruzi C-8 sterol isomerase, putative 0.5546 0.6997 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0007 0.0006
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.001 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0199 0.3092
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0059 0.0058 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0007 0.0007
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0007 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0008 0.0007
Trypanosoma cruzi C-14 sterol reductase, putative 0.0091 0.0097 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0008 0.0007
Echinococcus granulosus synaptic vesicular amine transporter 0.0581 0.0717 0.0716
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.001 0.0012
Trichomonas vaginalis glycogen phosphorylase, putative 0.0319 0.0386 0.6108
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0008 0.0007
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0006 0.0007
Brugia malayi neuropeptide F receptor 0.002 0.0007 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0029 0.0019 0.0018
Brugia malayi Serotonin receptor 0.002 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0018
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0007 0.0006
Echinococcus granulosus g protein coupled receptor 0.002 0.0007 0.0006
Toxoplasma gondii hypothetical protein 0.0027 0.0016 0.2186
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0007 0.0006
Brugia malayi G-protein coupled receptor 0.002 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.002 0.0008 0.0007
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.0041 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0016 0.0016
Echinococcus granulosus serotonin transporter 0.0158 0.0182 0.0181
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.0041 0.004
Echinococcus multilocularis lamin b receptor 0.0091 0.0097 0.0096
Echinococcus granulosus allatostatin A receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0008 0.0008
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0007 0.0006
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0007 0.0006
Echinococcus multilocularis neuropeptide receptor 0.002 0.0007 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0007 0.0006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0008 0.0007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0006 0.0006
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0158 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0009
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0138 0.0157 0.9684
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Loa Loa (eye worm) MH2 domain-containing protein 0.0112 0.0124 0.0123
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.2186
Brugia malayi nuclear hormone receptor 0.002 0.0008 0.0008
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0007 0.0006
Schistosoma mansoni glycogen phosphorylase 0.0319 0.0386 0.0385
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0052 0.8032
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0312 0.4915
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0141 0.8646
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.001 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0007 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0112 0.0124 0.0123
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0016 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0008 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0007 0.0006
Echinococcus granulosus survival motor neuron protein 1 0.027 0.0323 0.0322
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Schistosoma mansoni Lamin B receptor (ERG24) 0.0091 0.0097 0.0096
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0007 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0033 0.588
Loa Loa (eye worm) norepinephrine transporter 0.0158 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0019 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0008 0.0007
Brugia malayi Pre-SET motif family protein 0.0064 0.0064 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0312 0.4915
Brugia malayi MH2 domain containing protein 0.0112 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0052 0.0051
Echinococcus granulosus hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus dna polymerase kappa 0.0022 0.001 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.021 0.3279
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0141 0.8646
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0007 0.0006
Schistosoma mansoni ap endonuclease 0.004 0.0033 0.0032
Echinococcus multilocularis dna polymerase kappa 0.0022 0.001 0.0009
Brugia malayi Thioredoxin reductase 0.0055 0.0052 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.002 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0008 0.0007
Echinococcus granulosus g-protein coupled receptor 0.002 0.0007 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0006 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0033 0.1717
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0016 0.0015
Schistosoma mansoni myosin xvIII 0.002 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Leishmania major C-14 sterol reductase, putative 0.0091 0.0097 0.013
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0019 0.2646
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0008 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0015
Schistosoma mansoni vesicular acetylcholine transporter 0.7921 1 1
Schistosoma mansoni opsin-like receptor 0.002 0.0007 0.0006
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Brugia malayi glutathione reductase 0.0055 0.0052 0.0052
Brugia malayi neuropeptide F receptor 0.002 0.0007 0.0007
Echinococcus granulosus g protein coupled receptor 0.002 0.0007 0.0006
Echinococcus multilocularis g protein coupled receptor 0.002 0.0007 0.0006
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0016 0.0015
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0162 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0199 0.0191
Brugia malayi ecdysteroid receptor 0.002 0.0008 0.0008
Loa Loa (eye worm) serotonin transporter b 0.0158 0.0182 0.0181
Schistosoma mansoni amine GPCR 0.002 0.0007 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Brugia malayi hypothetical protein 0.027 0.0323 0.0323
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0033 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0008 0.0008
Loa Loa (eye worm) RecQ helicase 0.0024 0.0013 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.001 0.0009
Echinococcus multilocularis sex peptide receptor 0.002 0.0007 0.0006
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.0016 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0159 0.8399
Schistosoma mansoni vesicular amine transporter 0.0581 0.0717 0.0716
Brugia malayi Abnormal catecholamine distribution protein 1 0.0581 0.0717 0.0717
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0064 0.0063
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0007 0.0006
Schistosoma mansoni sodium/chloride dependent transporter 0.0158 0.0182 0.0181
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0033 0.0033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0008 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0008 0.0007
Onchocerca volvulus 0.0055 0.0052 0.0045
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.0323 0.0322
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0013 0.0012
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.2186
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0033 0.1717
Schistosoma mansoni biogenic amine receptor 0.002 0.0007 0.0006
Brugia malayi TAR-binding protein 0.0059 0.0058 0.0058
Echinococcus multilocularis orexin receptor type 2 0.002 0.0007 0.0006
Schistosoma mansoni biogenic amine receptor 0.002 0.0007 0.0006
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0008 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0006 0.0007
Loa Loa (eye worm) solute carrier family 6 member 4 0.0158 0.0182 0.0181
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) glutathione reductase 0.0055 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus multilocularis glycogen phosphorylase 0.0319 0.0386 0.0385
Echinococcus granulosus tm gpcr rhodopsin 0.1125 0.1405 0.1404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0064 0.0063
Schistosoma mansoni neuropeptide receptor 0.002 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0199 0.3092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0033 0.0038
Brugia malayi Melatonin receptor type 1A 0.002 0.0007 0.0007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0007 0.0006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0033 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.035 1
Plasmodium vivax SET domain protein, putative 0.0064 0.0064 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0319 0.0386 0.6108
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0007 0.0006
Brugia malayi nuclear receptor NHR-88 0.002 0.0008 0.0008
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0009 0.0652
Plasmodium falciparum glutathione reductase 0.0055 0.0052 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.001 0.0005
Entamoeba histolytica glycogen phosphorylase, putative 0.0319 0.0386 1
Brugia malayi Dopamine receptor 0.002 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.0027 0.0016 0.2186
Brugia malayi Serotonin receptor 0.002 0.0007 0.0007
Echinococcus granulosus orexin receptor type 2 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0007 0.0006
Echinococcus multilocularis serotonin transporter 0.0158 0.0182 0.0181
Schistosoma mansoni neuropeptide receptor 0.002 0.0007 0.0006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0008 0.0007
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0007 0.0006
Echinococcus granulosus glycogen phosphorylase 0.0319 0.0386 0.0385
Echinococcus multilocularis fmrfamide receptor 0.002 0.0007 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.5546 0.6997 0.6996
Trypanosoma brucei C-14 sterol reductase, putative 0.0091 0.0097 0.0137
Brugia malayi ORL1-like opioid receptor 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0032 0.0023 0.0022
Schistosoma mansoni biogenic amine receptor 0.002 0.0007 0.0006
Schistosoma mansoni survival motor neuron protein 0.0055 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Schistosoma mansoni glycogen phosphorylase 0.0319 0.0386 0.0385
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.035 0.9033
Brugia malayi RE15519p 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Brugia malayi Bromodomain containing protein 0.0029 0.0019 0.0019
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0007 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0159 0.9783
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) RNA binding protein 0.0059 0.0058 0.0056
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.001 0.0012
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0064 0.0064 0.0063
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0158 0.0182 0.0181
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0007 0.0006
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0013 0.0108
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0141 0.8646
Schistosoma mansoni amine GPCR 0.002 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Toxoplasma gondii thioredoxin reductase 0.0055 0.0052 0.804
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0312 0.4915
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus neuropeptide receptor 0.002 0.0007 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0008 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0064 1
Schistosoma mansoni histamine h1 receptor 0.002 0.0007 0.0006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0052 0.0051
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.0339 0.0338
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0007 0.0006
Onchocerca volvulus Glycogen phosphorylase homolog 0.0319 0.0386 0.0379
Echinococcus granulosus neuropeptide s receptor 0.002 0.0007 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1125 0.1405 0.1404
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0023 0.0023
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0141 0.8646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0007 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0007 0.0006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0006 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0008 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0058 0.0056
Trypanosoma brucei C-8 sterol isomerase, putative 0.5546 0.6997 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0007 0.0006
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.021 0.3279
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0019 0.0018
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0033 0.0032
Brugia malayi G-protein coupled receptor 0.002 0.0007 0.0007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0007 0.0006
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0016 0.2154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0008 0.0007
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0006 0.0578
Echinococcus multilocularis tar DNA binding protein 0.0059 0.0058 0.0056
Echinococcus multilocularis glycogen phosphorylase 0.0319 0.0386 0.0385
Echinococcus granulosus peregrin 0.0029 0.0019 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0007 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0007 0.0006
Entamoeba histolytica glycogen phosphorylase, putative 0.0319 0.0386 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.035 0.5523
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0008 0.0008
Onchocerca volvulus 0.002 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.2835 0.3567 0.3567
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0052 0.0065
Plasmodium falciparum transporter, putative 0.0027 0.0016 0.2155
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0008 0.0008
Echinococcus multilocularis serotonin receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus multilocularis Glycosyl transferase, family 35 0.0319 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0016 0.0015
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0007 0.0006
Echinococcus multilocularis neuropeptide receptor 0.002 0.0007 0.0006
Schistosoma mansoni amine GPCR 0.002 0.0007 0.0006
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0027 0.0026
Brugia malayi ERG2 and Sigma1 receptor like protein 0.5546 0.6997 0.6997
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0008 0.0001
Schistosoma mansoni ap endonuclease 0.004 0.0033 0.0032
Leishmania major C-8 sterol isomerase-like protein 0.5546 0.6997 1
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Brugia malayi larval opioid receptor 0.002 0.0007 0.0007
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0016 0.0015
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0008 0.0008
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0016 0.0015
Echinococcus granulosus fmrfamide receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0449 0.055 0.0549
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0007 0.0006
Schistosoma mansoni glycogen phosphorylase 0.0138 0.0157 0.0156
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0007 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0033 0.0038
Brugia malayi hypothetical protein 0.0027 0.0016 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0007 0.0006
Brugia malayi jmjC domain containing protein 0.0035 0.0027 0.0027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0033 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0199 0.3092
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0008 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0041 0.004
Echinococcus granulosus bloom syndrome protein 0.0024 0.0013 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0016 0.0015
Echinococcus multilocularis g protein coupled receptor 0.002 0.0007 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0006
Echinococcus granulosus sex peptide receptor 0.002 0.0007 0.0006
Trypanosoma cruzi sterol C-24 reductase, putative 0.0047 0.0042 0.0051
Giardia lamblia PHD finger protein 15 0.0029 0.0019 0.0331
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0064 0.0063
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0016 0.0015
Echinococcus multilocularis somatostatin receptor 0.002 0.0007 0.0006
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0016 0.0015
Schistosoma mansoni adenoreceptor 0.002 0.0007 0.0006
Echinococcus multilocularis peregrin 0.0029 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0016 0.0015
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.0016 0.0015
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.7921 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0199 0.3092
Brugia malayi GnHR receptor homolog 0.002 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.002 0.0007 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0008 0.0007
Trypanosoma brucei unspecified product 0.0022 0.001 0.0012
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0007 0.0006
Brugia malayi sulfakinin receptor protein 0.002 0.0007 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0006 0.0539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0007 0.0006

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 12.2 uM Cytoprotective activity against H2O2-induced cell injury in HUVEC cells ChEMBL. 20621727

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20621727

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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