Detailed information for compound 1166578

Basic information

Technical information
  • TDR Targets ID: 1166578
  • Name: N-(3-chlorophenyl)-N'-(furan-2-ylmethyl)quina zoline-2,4-diamine
  • MW: 350.802 | Formula: C19H15ClN4O
  • H donors: 2 H acceptors: 2 LogP: 4.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)Nc1nc(NCc2ccco2)c2c(n1)cccc2
  • InChi: 1S/C19H15ClN4O/c20-13-5-3-6-14(11-13)22-19-23-17-9-2-1-8-16(17)18(24-19)21-12-15-7-4-10-25-15/h1-11H,12H2,(H2,21,22,23,24)
  • InChiKey: KLRNKMZSARWWTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-chlorophenyl)-N'-(2-furylmethyl)quinazoline-2,4-diamine
  • [2-[(3-chlorophenyl)amino]quinazolin-4-yl]-(2-furylmethyl)amine
  • ZINC01105529
  • Neuro1_000229
  • Oprea1_495764
  • EU-0011139
  • ChemDiv1_009716
  • STOCK3S-16531
  • Oprea1_820694

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0244 0.0362
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0809 0.0799
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0302 0.1433
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0128 0.1655 1
Brugia malayi hypothetical protein 0.0009 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0028
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0111 0.0225
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.2249 0.339
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0187 0.0176
Loa Loa (eye worm) hypothetical protein 0.0022 0.0187 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0041 0.0055
Schistosoma mansoni hypothetical protein 0.0469 0.6384 0.638
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0111 0.0225
Schistosoma mansoni ran 0.0022 0.0191 0.0179
Brugia malayi hypothetical protein 0.0041 0.0452 0.0682
Loa Loa (eye worm) hypothetical protein 0.0487 0.6633 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0673 0.1009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0344 0.0333
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0187 0.0704
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0033 0.0021
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0258 0.0731
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.027 0.2444
Brugia malayi hypothetical protein 0.0299 0.4035 0.6082
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0809 0.0799
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0387 0.0376
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1269 0.3376
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.3528 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0487 0.3996
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0041 0.0055
Trypanosoma brucei calpain-like protein, putative 0.0128 0.1655 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0111 0.0168
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0244 0.0692
Loa Loa (eye worm) Smad1 0.0025 0.0221 0.0327
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0387 0.1969
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0914 0.5309
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0092 0.0101
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0191 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0041 0.0062
Mycobacterium ulcerans fatty acid synthase Fas 0.0009 0.0003 0.0024
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0582 0.0571
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.3282 0.4944
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.1269 0.1908
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0387 0.0376
Loa Loa (eye worm) hypothetical protein 0.0036 0.0387 0.0577
Brugia malayi Sulfatase family protein 0.0009 0.0004 0.0006
Onchocerca volvulus 0.0012 0.0041 0.0055
Brugia malayi beta-lactamase family protein 0.0041 0.0451 0.068
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0076 0.0191
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0102 0.0288
Echinococcus granulosus geminin 0.0347 0.4692 0.4686
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1104 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0187 0.0704
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.016 0.0454
Brugia malayi MH1 domain containing protein 0.0025 0.0221 0.0333
Loa Loa (eye worm) hypothetical protein 0.0047 0.0535 0.08
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0451 0.4073
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0302 0.2192
Mycobacterium tuberculosis Conserved protein 0.0041 0.0451 0.1279
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0111 0.0225
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0582 0.3205
Loa Loa (eye worm) beta-lactamase 0.0041 0.0451 0.0674
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0033 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0187 0.0704
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0041 0.0055
Schistosoma mansoni hypothetical protein 0.0018 0.0131 0.012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0041 0.0062
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.2249 0.224
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0406 0.1072
Brugia malayi MH2 domain containing protein 0.0025 0.0221 0.0333
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0128 0.1655 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0487 0.0476
Entamoeba histolytica Ran family GTPase 0.0022 0.0191 0.0962
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0582 0.0571
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1104 1
Schistosoma mansoni hypothetical protein 0.0033 0.0344 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0406 0.1072
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0809 0.0799
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0294 0.2663
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0451 0.044
Schistosoma mansoni smad1 5 8 and 0.0025 0.0221 0.021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0814 0.7175
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.1104 0.1094
Onchocerca volvulus 0.0279 0.375 0.5651
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.1104 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0344 0.0333
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.1269 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.1269 0.1259
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.027 0.2444
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0377 0.0366
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0028 0.027 0.0765
Loa Loa (eye worm) MH2 domain-containing protein 0.0361 0.4885 0.7362
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0406 0.2089
Mycobacterium ulcerans sulfatase 0.0009 0.0004 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0914 0.8087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0041 0.0062
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0487 0.129
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.1104 0.1094
Schistosoma mansoni hypothetical protein 0.0031 0.0312 0.03
Loa Loa (eye worm) hypothetical protein 0.0057 0.0673 0.1009
Echinococcus granulosus tar DNA binding protein 0.0067 0.0809 0.0799
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0302 0.1918
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0041 0.0029
Entamoeba histolytica hypothetical protein 0.0041 0.0452 0.3155
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0451 0.4087
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0451 0.044
Schistosoma mansoni cpg binding protein 0.0035 0.0363 0.0352
Onchocerca volvulus 0.0049 0.0558 0.0836
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0041 0.0029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0451 0.4087
Brugia malayi MH2 domain containing protein 0.0361 0.4885 0.7364
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0582 0.3205
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0076 0.0115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0041 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0041 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0131 0.012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0406 0.2765
Brugia malayi hypothetical protein 0.0487 0.6633 1
Onchocerca volvulus 0.0099 0.125 0.1879
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0191 0.0727
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0187 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0041 0.0062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0222 0.0582
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0187 0.0176
Entamoeba histolytica hypothetical protein 0.0041 0.0452 0.3155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0507 0.0496
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0222 0.0582
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0076 0.0191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0041 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Schistosoma mansoni Smad4 0.0025 0.0221 0.021
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0076 0.0108
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0464
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0571 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0128 0.1655 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0582 0.3205
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1269 0.3376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0041 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0041 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0507 0.0496
Schistosoma mansoni ran 0.0022 0.0191 0.0179
Entamoeba histolytica hypothetical protein 0.0041 0.0452 0.3155
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0221 0.021
Onchocerca volvulus Fatty acid synthase homolog 0.0051 0.0582 0.0872
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0221 0.0327
Brugia malayi Temporarily assigned gene name protein 44 0.0031 0.0312 0.047
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0406 0.1072
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0387 0.1021
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0809 0.0799
Trichomonas vaginalis set domain proteins, putative 0.0279 0.375 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.01
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0041 0.0062
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0221 0.0327
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0128 0.1655 1
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0004 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0041 0.0029
Schistosoma mansoni microtubule-associated protein tau 0.0729 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0041 0.0062
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0023 0.0199 0.0564
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0187 0.1695
Mycobacterium ulcerans lipase LipD 0.0041 0.0451 0.4087
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.1269 0.7556
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0131 0.0191
Schistosoma mansoni hypothetical protein 0.0031 0.0312 0.03
Brugia malayi follicle stimulating hormone receptor 0.0229 0.3053 0.4602
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0076 0.0191
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0451 0.1193
Echinococcus multilocularis dnaJ subfamily B 0.0469 0.6384 0.638
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0041 0.0055
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0387 0.0376
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0437 0.3421
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0387 0.1969
Onchocerca volvulus 0.0041 0.0451 0.0674
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0673 0.1014
Echinococcus granulosus dna polymerase eta 0.0022 0.0187 0.0176
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0674
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0582 0.3205
Onchocerca volvulus 0.0033 0.0337 0.0502
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0674
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0406 0.1072
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1269 0.3376
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1887 0.1878
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1269 0.7556
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0042 0.0462 0.1311
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0041 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0809 0.0799
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0437 0.3279
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0507 0.0758
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0019 0.0138 0.1228
Onchocerca volvulus 0.0026 0.0244 0.0362
Entamoeba histolytica hypothetical protein 0.0025 0.0222 0.1227
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0582 0.4917
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.1945 0.2932
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0914 0.8087
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0302 0.1918
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0809 0.122
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0451 0.3423
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0111 0.0225
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0377 0.2917
Schistosoma mansoni alpha-glucosidase 0.0147 0.1919 0.1909
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0451 0.068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0377 0.0366
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0451 0.2376
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.1269 0.1259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0507 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Brugia malayi Probable ClpP-like protease 0.0088 0.1104 0.1664
Echinococcus multilocularis geminin 0.0347 0.4692 0.4686
Loa Loa (eye worm) tumor suppressor 0.0367 0.498 0.7505
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1104 1
Entamoeba histolytica hypothetical protein 0.0041 0.0452 0.3155
Schistosoma mansoni hypothetical protein 0.0347 0.4692 0.4686
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0451 0.1193
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0042 0.0462 0.1311
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.027 0.0765
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0041 0.0062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0377 0.0562
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0191 0.0281
Echinococcus multilocularis microtubule associated protein 2 0.0729 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0128 0.1655 1
Echinococcus multilocularis smad 0.0025 0.0221 0.021
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0111 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0004 0.0012
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.1269 0.1908
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0387 0.2606
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0406 0.1072
Schistosoma mansoni smad1 5 8 and 0.0025 0.0221 0.021
Schistosoma mansoni importin beta-1 0.003 0.0302 0.0291
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0033 0.0043
Onchocerca volvulus 0.0036 0.0377 0.0562
Loa Loa (eye worm) hypothetical protein 0.003 0.0302 0.0449
Loa Loa (eye worm) hypothetical protein 0.0074 0.0914 0.1372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0041 0.0029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0809 0.1214
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0406 0.1072
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Schistosoma mansoni hypothetical protein 0.0347 0.4692 0.4686
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0076 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0111 0.01
Schistosoma mansoni alpha glucosidase 0.0038 0.0406 0.0395
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.4385 0.6608
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0809 0.1214
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0221 0.021
Brugia malayi Pre-SET motif family protein 0.0036 0.0377 0.0568
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0387 0.1969
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0302 0.2717
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0258 0.0731
Brugia malayi Smad1 0.0025 0.0221 0.0333
Brugia malayi ecdysteroid receptor 0.0012 0.0041 0.0062
Leishmania major importin beta-1 subunit, putative 0.0025 0.0222 0.0927
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0387 0.1021
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0041 0.0062
Brugia malayi steroid hormone receptor 0.0012 0.0041 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0674
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0041 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0451 0.1279
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0041 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0041 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0041 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0041 0.0029
Loa Loa (eye worm) nuclear factor I 0.0014 0.0069 0.0097
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0023 0.0194 0.1754
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.1269 0.1913
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0059 0.0083
Schistosoma mansoni Smad4 0.0011 0.0033 0.0021
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0039 0.0053
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0221 0.021
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0004 0.0038
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0221 0.021
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0041 0.0029
Brugia malayi Importin beta-1 subunit 0.003 0.0302 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.2249 0.224
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.01
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0451 0.1193
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0004 0.0038
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0682 0.1934
Brugia malayi RNA binding protein 0.0067 0.0809 0.122
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1104 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.1104 0.1094
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0187 0.053
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0582 0.3205
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0387 0.1021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0041 0.0029
Brugia malayi beta-lactamase 0.0041 0.0451 0.068
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.027 0.0765
Echinococcus granulosus cpg binding protein 0.0035 0.0363 0.0352
Brugia malayi MH2 domain containing protein 0.0025 0.0221 0.0333
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0187 0.0932
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0076 0.0191
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0041 0.0029
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0191 0.0727
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0582 0.1542
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0302 0.1433
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0265 0.0393
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0033 0.0043
Brugia malayi tumor suppressor. 0.0367 0.498 0.7507
Schistosoma mansoni DNA polymerase eta 0.0022 0.0187 0.0176
Schistosoma mansoni alpha-glucosidase 0.0147 0.1919 0.1909
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0028 0.027 0.2426
Schistosoma mansoni cpg binding protein 0.0033 0.0337 0.0326
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0043
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.027 0.2444
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0406 0.0606
Mycobacterium ulcerans beta-lactamase 0.0041 0.0451 0.4087
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0582 0.3205
Brugia malayi hypothetical protein 0.0031 0.0312 0.047
Schistosoma mansoni smad 0.0025 0.0221 0.021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0451 0.044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0867 0.0856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0041 0.0055
Brugia malayi MH1 domain containing protein 0.0014 0.0069 0.0104
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0033 0.0021
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0582 0.0571
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0451 0.044
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0158 0.0783
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0406 0.2765
Brugia malayi nuclear hormone receptor 0.0012 0.0041 0.0062
Echinococcus granulosus snurportin 1 0.0325 0.4385 0.4378
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1269 0.3376
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0187 0.0488
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0582 0.0571
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0406 0.1072
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0387 0.0376
Brugia malayi Pre-SET motif family protein 0.0245 0.3282 0.4947
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0406 0.2089
Brugia malayi isocitrate dehydrogenase 0.0017 0.0111 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0571 0.1512
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1269 0.1259
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0033 0.0043
Brugia malayi MAP kinase sur-1 0.0051 0.0582 0.0877
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0187 0.053
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0387 0.0376
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0221 0.021
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1269 0.3376
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0451 0.1193
Trypanosoma brucei glucosidase, putative 0.0038 0.0406 0.2089
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0205 0.1856
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0191 0.0179
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0041 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0582 0.0571
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0128 0.1655 1
Echinococcus multilocularis protein quaking 0.0031 0.0312 0.03
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0187 0.0282
Trypanosoma brucei hypothetical protein 0.0128 0.1655 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0377 0.0366
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0582 0.3205
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0041 0.0062
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0406 0.1072
Trypanosoma brucei calpain, putative 0.0128 0.1655 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.0294 0.0833
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0019 0.0138 0.1249
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0209 0.0309
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0187 0.0276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0377 0.0366
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0674
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0387 0.0376
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0349 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0191
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1104 0.5
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0682 0.0672
Brugia malayi TAR-binding protein 0.0067 0.0809 0.122
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0451 0.1193
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0914 0.8087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0041 0.0055
Loa Loa (eye worm) acetyltransferase 0.0149 0.1945 0.2928
Trypanosoma brucei polo-like protein kinase 0.01 0.1269 0.7556
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0682 0.0672
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0205 0.0581
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.1945 0.1936
Echinococcus multilocularis GPCR, family 2 0.0018 0.0131 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0377 0.0366
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Onchocerca volvulus 0.0041 0.0451 0.0674
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0191 0.1107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0507 0.0764
Mycobacterium ulcerans polyketide synthase 0.003 0.0294 0.2663
Schistosoma mansoni hypothetical protein 0.0039 0.0422 0.0411
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0452 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0187 0.0704
Schistosoma mansoni hypothetical protein 0.0018 0.0131 0.012
Giardia lamblia DINP protein human, muc B family 0.0022 0.0187 0.1446
Brugia malayi nuclear receptor NHR-88 0.0012 0.0041 0.0062
Echinococcus multilocularis dna polymerase eta 0.0022 0.0187 0.0176
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0406 0.1072
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.027 0.2444
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0191 0.0288
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0406 0.0612
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0222 0.0927
Echinococcus multilocularis cpg binding protein 0.0035 0.0363 0.0352
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0076 0.0191
Brugia malayi CXXC zinc finger family protein 0.0033 0.0337 0.0508
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0041 0.0029
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0191 0.1475
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0452 0.0441
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.003 0.0294 0.2646
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0422 0.0636
Onchocerca volvulus 0.0041 0.0451 0.0674
Mycobacterium leprae Polyketide synthase Pks13 0.0042 0.0462 0.4175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0041 0.0055
Mycobacterium tuberculosis Polyketide synthase Pks12 0.003 0.0294 0.0833
Loa Loa (eye worm) RNA binding protein 0.0067 0.0809 0.1214
Leishmania major DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0406 0.2089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0041 0.0062
Echinococcus granulosus importin subunit beta 1 0.003 0.0302 0.0291
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0191 0.0799
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.2249 0.224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0507 0.0496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0507 0.0496
Schistosoma mansoni hypothetical protein 0.0018 0.0131 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0507 0.0496
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0041 0.0062
Trichomonas vaginalis ran, putative 0.0022 0.0191 0.0498
Trypanosoma brucei protein kinase, putative 0.0051 0.0582 0.3205
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0041 0.0029
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0377 0.0366
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0004 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.3053 0.4599
Brugia malayi RNA, U transporter 1 0.0086 0.108 0.1628
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0451 0.1279
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.003 0.0294 0.0833
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0682 0.6172
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0187 0.0282
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0914 0.5309
Mycobacterium ulcerans thioesterase 0.0023 0.0205 0.1856
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0244 0.0368
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0023 0.0194 0.1735
Brugia malayi Cytochrome P450 family protein 0.0024 0.0209 0.0315
Echinococcus granulosus hypothetical protein 0.0031 0.0312 0.03
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0406 0.0395
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0111 0.01
Schistosoma mansoni kinase 0.0051 0.0589 0.0578
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0437 0.3025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0451 0.1279
Brugia malayi MH2 domain containing protein 0.0011 0.0033 0.0049
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0406 0.3201
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0053 0.0619 0.0933
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0108
Leishmania major hypothetical protein, conserved 0.0074 0.0914 0.5309
Trypanosoma brucei unspecified product 0.0022 0.0187 0.0704
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0009 0.0003 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0041 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0041 0.0062
Trichomonas vaginalis esterase, putative 0.0041 0.0451 0.1193
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0041 0.0029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0674
Brugia malayi hypothetical protein 0.0048 0.0548 0.0826
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0128 0.1655 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0673 0.1014
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0041 0.0029
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0682 0.1934
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0023 0.0194 0.1754
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0451 0.1279
Schistosoma mansoni cpg binding protein 0.0035 0.0363 0.0352
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0582 0.1542
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0092 0.0101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0041 0.0055
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1104 0.5
Plasmodium falciparum importin beta, putative 0.003 0.0302 0.1922
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0387 0.0376
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0187 0.0176
Toxoplasma gondii type I fatty acid synthase, putative 0.003 0.0294 0.2112
Schistosoma mansoni hypothetical protein 0.0041 0.0452 0.0441
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0914 0.8151
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0387 0.0583
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0076 0.0191
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0033 0.0021
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0028 0.027 0.2426
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0111 0.01
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.1104 1
Brugia malayi beta-lactamase family protein 0.0041 0.0451 0.068
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0406 0.0395
Toxoplasma gondii ABC1 family protein 0.0041 0.0451 0.3643
Toxoplasma gondii hypothetical protein 0.003 0.0302 0.2189
Schistosoma mansoni smad 0.0011 0.0033 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0452 0.0441
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0187 0.0176
Schistosoma mansoni hypothetical protein 0.0325 0.4385 0.4378
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0131 0.012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0487 0.3788
Schistosoma mansoni smad1 5 8 and 0.0025 0.0221 0.021
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1269 0.7556
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0582 0.1542
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0131 0.0198
Loa Loa (eye worm) hypothetical protein 0.0039 0.0422 0.063
Echinococcus granulosus GPCR family 2 0.0018 0.0131 0.012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0451 0.0674
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0111 0.0225
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0131 0.012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.0038 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0076 0.0191
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0487 0.129
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0041 0.0029
Echinococcus multilocularis Smad4 0.0025 0.0221 0.021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0222 0.0582
Echinococcus granulosus dna polymerase kappa 0.0022 0.0187 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0092 0.0101
Echinococcus multilocularis snurportin 1 0.0325 0.4385 0.4378
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0187 0.1695
Mycobacterium ulcerans hypothetical protein 0.0041 0.0451 0.4087
Leishmania major hypothetical protein, conserved 0.0041 0.0451 0.2376
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.003 0.0294 0.2646
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0041 0.0062
Echinococcus granulosus smad 0.0025 0.0221 0.021
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0205 0.1836
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0041 0.0055
Brugia malayi hypothetical protein 0.0074 0.0914 0.1378
Mycobacterium ulcerans polyketide synthase Pks13 0.0042 0.0462 0.4189
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0187 0.0176
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0451 0.2376
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0142
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0038 0.0057
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0004 0.0038
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0487 0.3996
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0387 0.3025
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0041 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0187 0.0704
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0451 0.2376
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1104 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0041 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0041 0.0029
Schistosoma mansoni coup transcription factor 0.0012 0.0041 0.0029
Plasmodium vivax importin-beta 2, putative 0.003 0.0302 0.1922
Echinococcus granulosus dnaJ subfamily B 0.0469 0.6384 0.638
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0028 0.027 0.0407
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0004 0.0012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0451 0.1279
Mycobacterium tuberculosis Conserved protein 0.0041 0.0451 0.1279
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1269 0.3376
Trypanosoma brucei unspecified product 0.0015 0.0092 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0377 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0041 0.0055
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0111 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1269 0.3376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0507 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0041 0.0062
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0191 0.0799
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0582 0.4569
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0914 0.5309
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0582 0.1542
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0004 0.0012
Echinococcus granulosus protein quaking 0.0031 0.0312 0.03
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0111 0.0334
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0451 0.1279
Brugia malayi MH1 domain containing protein 0.0025 0.0221 0.0333
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.001 0.0014 0.004
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0809 0.0799
Loa Loa (eye worm) hypothetical protein 0.0127 0.1639 0.2466
Mycobacterium tuberculosis Conserved protein 0.0041 0.0451 0.1279
Onchocerca volvulus 0.0487 0.6633 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.2249 0.3386
Mycobacterium ulcerans hydrolase 0.0009 0.0004 0.0038
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0387 0.0376
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0337 0.0502
Mycobacterium leprae Probable lipase LipE 0.0041 0.0451 0.4073
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0387 0.1969
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.1945 0.1936
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0128 0.1655 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0377 0.2672
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1104 1
Schistosoma mansoni Smad4 0.0011 0.0033 0.0021
Leishmania major DNA polymerase eta, putative 0.0022 0.0187 0.0704
Mycobacterium leprae Probable polyketide synthase Pks1 0.003 0.0294 0.2646
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0674
Mycobacterium ulcerans polyketide synthase 0.0028 0.027 0.2444
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0041 0.0029
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0133 0.0544
Schistosoma mansoni hypothetical protein 0.0018 0.0131 0.012
Trypanosoma brucei unspecified product 0.0015 0.0092 0.0101
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0041 0.0029
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0041 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0187 0.0704
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.1104 1
Mycobacterium ulcerans polyketide synthase Pks9 0.0019 0.0138 0.1249
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0187 0.0488
Leishmania major GTP-binding protein, putative 0.0022 0.0191 0.0727
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.0294 0.2663
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0131 0.0198
Loa Loa (eye worm) hypothetical protein 0.0088 0.1104 0.1659
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0451 0.1279
Echinococcus granulosus Smad4 0.0025 0.0221 0.021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0131 0.012
Echinococcus multilocularis importin subunit beta 1 0.003 0.0302 0.0291
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0191 0.0179
Loa Loa (eye worm) transcription factor SMAD2 0.0361 0.4885 0.7362
Giardia lamblia Kinase, PLK 0.01 0.1269 1
Brugia malayi MH1 domain containing protein 0.0014 0.0069 0.0104
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0033 0.0049
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0111 0.0334
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0582 0.0871

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.