Detailed information for compound 1177992

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 911.123 | Formula: C48H78O16
  • H donors: 8 H acceptors: 9 LogP: 3.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](O[C@H]2CC[C@]3([C@H](C2(C)C)CC[C@@]2([C@@H]3CC[C@H]3[C@@]2(C)CC[C@]24[C@@H]3[C@@H](OC4=O)C(C)(C)CC2)C)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
  • InChi: 1S/C48H78O16/c1-21-29(50)31(52)33(54)39(58-21)62-36-24(20-49)60-41(37(35(36)56)63-40-34(55)32(53)30(51)22(2)59-40)61-27-13-14-45(7)25(44(27,5)6)12-15-47(9)26(45)11-10-23-28-38-43(3,4)16-18-48(28,42(57)64-38)19-17-46(23,47)8/h21-41,49-56H,10-20H2,1-9H3/t21-,22-,23+,24+,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,35-,36+,37+,38+,39-,40-,41-,45-,46+,47+,48-/m0/s1
  • InChiKey: JMIDUDJEXRNMCX-XMGSOJISSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.046 0.9305 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0243 0.0386
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.046 0.9305 1
Plasmodium vivax peptide deformylase, putative 0.046 0.9305 1
Toxoplasma gondii ABC1 family protein 0.0077 0.1421 0.1252
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0503 0.0616
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1086 0.1637
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.046 0.9305 0.9288
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.131 0.1604
Trypanosoma brucei unspecified product 0.002 0.0243 0.0386
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0957 0.1545
Onchocerca volvulus 0.027 0.5394 1
Echinococcus granulosus geminin 0.0168 0.3282 0.402
Loa Loa (eye worm) hypothetical protein 0.0121 0.2326 0.4158
Chlamydia trachomatis peptide deformylase 0.046 0.9305 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1421 0.3679
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0243 0.0386
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.1006 0.1232
Leishmania major polypeptide deformylase-like protein, putative 0.0175 0.3445 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.3345 0.6023
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.023 0.456 0.5585
Toxoplasma gondii hypothetical protein 0.046 0.9305 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.2552 0.3125
Mycobacterium ulcerans lipase LipD 0.0077 0.1421 0.13
Loa Loa (eye worm) hypothetical protein 0.0057 0.1006 0.1761
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0035
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1421 0.174
Trypanosoma cruzi Peptide deformylase 2, putative 0.0175 0.3445 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0959 0.1549
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0243 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0243 0.0386
Schistosoma mansoni bromodomain containing protein 0.0011 0.0055 0.0067
Schistosoma mansoni cpg binding protein 0.0034 0.0534 0.0654
Brugia malayi Pre-SET motif family protein 0.0035 0.0541 0.0778
Brugia malayi TAR-binding protein 0.0063 0.112 0.1845
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.112 0.1845
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0957 0.1173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0293 0.0051
Treponema pallidum polypeptide deformylase (def) 0.046 0.9305 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0243 0.0297
Echinococcus multilocularis dna polymerase kappa 0.002 0.0243 0.0297
Trypanosoma brucei protein kinase, putative 0.0061 0.1086 0.2918
Schistosoma mansoni tar DNA-binding protein 0.0063 0.112 0.1372
Loa Loa (eye worm) hypothetical protein 0.0077 0.1421 0.2515
Loa Loa (eye worm) beta-lactamase 0.0077 0.1421 0.2515
Trichomonas vaginalis esterase, putative 0.0077 0.1421 0.2287
Loa Loa (eye worm) hypothetical protein 0.0077 0.1421 0.2515
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0293 0.0157
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.5371 0.6578
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.1006 0.1232
Schistosoma mansoni survival motor neuron protein 0.0055 0.0959 0.1175
Brugia malayi hypothetical protein 0.0121 0.2326 0.4068
Loa Loa (eye worm) hypothetical protein 0.0077 0.1421 0.2515
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1421 0.1207
Schistosoma mansoni hypothetical protein 0.0168 0.3282 0.402
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.1086 0.2634
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0293 0.0097
Schistosoma mansoni bromodomain containing protein 0.014 0.2713 0.3323
Loa Loa (eye worm) hypothetical protein 0.0269 0.5371 0.9688
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0293 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0957 0.1173
Loa Loa (eye worm) hypothetical protein 0.0175 0.3444 0.6188
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1421 0.1207
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0625 0.107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0293 0.0157
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0243 0.0297
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.131 0.1604
Trypanosoma brucei Peptide deformylase 2 0.0175 0.3445 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0036 0.0044
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.1086 0.2634
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.1086 0.133
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0277 0.5543 1
Onchocerca volvulus 0.0035 0.0541 0.0255
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1421 0.13
Echinococcus multilocularis geminin 0.0168 0.3282 0.402
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1421 0.1207
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.1086 0.133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Echinococcus granulosus zinc finger protein 0.0044 0.0744 0.0911
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1086 0.1637
Brugia malayi Bromodomain containing protein 0.0166 0.3241 0.5756
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.131 0.1604
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1421 0.1207
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.1086 0.2634
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1421 0.13
Echinococcus multilocularis cpg binding protein 0.0034 0.0534 0.0654
Trichomonas vaginalis set domain proteins, putative 0.027 0.5394 1
Mycobacterium ulcerans peptide deformylase 0.046 0.9305 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0414 0.0687
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0293 0.032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0293 0.0157
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0878 0.1075
Loa Loa (eye worm) hypothetical protein 0.0084 0.1558 0.2763
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0243 0.0227
Trypanosoma brucei Polypeptide deformylase 1 0.0175 0.3445 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.1169 0.1431
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1086 0.1637
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.1448 0.1773
Mycobacterium tuberculosis Conserved protein 0.0077 0.1421 0.1207
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0243 0.0386
Brugia malayi beta-lactamase family protein 0.0077 0.1421 0.2399
Echinococcus multilocularis dna polymerase eta 0.002 0.0243 0.0297
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1421 0.2399
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0541 0.0276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.131 0.1604
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.112 0.1969
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.1006 0.1761
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.1086 0.088
Brugia malayi beta-lactamase 0.0077 0.1421 0.2399
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0293 0.0097
Brugia malayi Bromodomain containing protein 0.0084 0.1554 0.2646
Trypanosoma cruzi Peptide deformylase 2, putative 0.0175 0.3445 1
Mycobacterium tuberculosis Conserved protein 0.0077 0.1421 0.1207
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.1086 0.2918
Schistosoma mansoni hypothetical protein 0.0033 0.0518 0.0635
Schistosoma mansoni hypothetical protein 0.0045 0.0758 0.0929
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1421 0.174
Brugia malayi MAP kinase sur-1 0.0061 0.1086 0.1782
Schistosoma mansoni zinc finger protein 0.0033 0.0518 0.0635
Schistosoma mansoni tar DNA-binding protein 0.0063 0.112 0.1372
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1421 0.1207
Brugia malayi beta-lactamase family protein 0.0077 0.1421 0.2399
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1421 0.3679
Brugia malayi CXXC zinc finger family protein 0.0028 0.0414 0.0543
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0957 0.1674
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.1006 0.1188
Schistosoma mansoni tar DNA-binding protein 0.0063 0.112 0.1372
Loa Loa (eye worm) TAR-binding protein 0.0063 0.112 0.1969
Schistosoma mansoni ap endonuclease 0.0023 0.0293 0.0359
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0597 0.0731
Onchocerca volvulus 0.0077 0.1421 0.2022
Loa Loa (eye worm) hypothetical protein 0.0077 0.1421 0.2515
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1421 0.1252
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1421 0.2515
Onchocerca volvulus 0.0055 0.0959 0.1095
Leishmania major hypothetical protein, conserved 0.0077 0.1421 0.3679
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0243 0.0376
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.5371 0.6578
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.1086 0.133
Loa Loa (eye worm) hypothetical protein 0.0121 0.2326 0.4158
Trypanosoma brucei ISWI complex protein 0.0033 0.0518 0.1213
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.1086 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0243 0.0297
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.8165 1
Brugia malayi hypothetical protein 0.0269 0.5371 0.9683
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.1006 0.1232
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.1006 0.1232
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0293 0.0595
Loa Loa (eye worm) hypothetical protein 0.0089 0.1664 0.2957
Echinococcus granulosus endonuclease exonuclease phosphatase 0.023 0.456 0.5585
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0597 0.0731
Loa Loa (eye worm) hypothetical protein 0.0077 0.1421 0.2515
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0293 0.0536
Echinococcus granulosus cpg binding protein 0.0034 0.0534 0.0654
Echinococcus multilocularis zinc finger protein 0.0044 0.0744 0.0911
Brugia malayi RNA binding protein 0.0063 0.112 0.1845
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.1086 0.133
Brugia malayi mbt repeat family protein 0.0057 0.1006 0.1634
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0878 0.1075
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1421 0.2287
Schistosoma mansoni cpg binding protein 0.0028 0.0414 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Onchocerca volvulus Huntingtin homolog 0.0121 0.2326 0.3839
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.472 0.8505
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1421 0.2287
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Plasmodium falciparum peptide deformylase 0.046 0.9305 1
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.1006 0.1232
Schistosoma mansoni ap endonuclease 0.0023 0.0293 0.0359
Brugia malayi Pre-SET motif family protein 0.0237 0.472 0.8482
Echinococcus multilocularis tar DNA binding protein 0.0063 0.112 0.1372
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Loa Loa (eye worm) RNA binding protein 0.0063 0.112 0.1969
Mycobacterium tuberculosis Conserved protein 0.0077 0.1421 0.1207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.2552 0.3125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0541 0.0663
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1421 0.2287
Loa Loa (eye worm) hypothetical protein 0.002 0.0243 0.0376
Echinococcus granulosus dna polymerase eta 0.002 0.0243 0.0297
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1421 0.2287
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1421 0.1207
Onchocerca volvulus 0.0057 0.1006 0.1188
Schistosoma mansoni tar DNA-binding protein 0.0063 0.112 0.1372
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.1086 0.2634
Schistosoma mansoni cpg binding protein 0.0034 0.0534 0.0654
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0293 0.0467
Echinococcus granulosus tar DNA binding protein 0.0063 0.112 0.1372
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.1448 0.1773
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0957 0.1173
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1421 0.1207
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.1169 0.1934
Loa Loa (eye worm) hypothetical protein 0.0095 0.1784 0.3174
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.1169 0.1431
Leishmania major hypothetical protein, conserved 0.0033 0.0518 0.086
Schistosoma mansoni hypothetical protein 0.0055 0.0959 0.1175
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.3444 0.613
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0957 0.1173
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.1006 0.1232
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1086 0.1637
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0293 0.0359
Loa Loa (eye worm) hypothetical protein 0.0072 0.131 0.2313
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0243 0.0297
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1421 0.2287
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0541 0.0663
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1421 0.174
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.1086 0.133
Brugia malayi mbt repeat family protein 0.0057 0.1006 0.1634
Mycobacterium ulcerans hypothetical protein 0.0077 0.1421 0.13
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0243 0.0227
Mycobacterium ulcerans beta-lactamase 0.0077 0.1421 0.13
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1096 0.1342
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1421 0.174
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0293 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0293 0.0359
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.107 0.0863
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0541 0.0663
Onchocerca volvulus Huntingtin homolog 0.0121 0.2326 0.3839
Trypanosoma cruzi ISWI complex protein 0.0033 0.0518 0.086
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.1169 0.1431
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0597 0.0731
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0957 0.1173
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.1086 0.1907
Schistosoma mansoni hypothetical protein 0.0352 0.7077 0.8667
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0957 0.1173
Loa Loa (eye worm) hypothetical protein 0.0155 0.3015 0.541
Loa Loa (eye worm) hypothetical protein 0.0065 0.1169 0.2057
Schistosoma mansoni zinc finger protein 0.0044 0.0744 0.0911
Schistosoma mansoni hypothetical protein 0.0404 0.8165 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.1086 0.2634
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.1006 0.1232
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0243 0.0297
Schistosoma mansoni hypothetical protein 0.0168 0.3282 0.402
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.1169 0.1431
Schistosoma mansoni tar DNA-binding protein 0.0063 0.112 0.1372
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.1086 0.2634
Brugia malayi PHD-finger family protein 0.0056 0.0985 0.1595
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.1169 0.1431
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0597 0.0731
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0243 0.0386
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0878 0.1075
Trypanosoma cruzi ISWI complex protein 0.0033 0.0518 0.086
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0758 0.1312
Onchocerca volvulus 0.0077 0.1421 0.2022
Loa Loa (eye worm) MBCTL1 0.0065 0.1169 0.2057
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0175 0.3445 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0175 0.3445 1
Onchocerca volvulus 0.0077 0.1421 0.2022
Brugia malayi follicle stimulating hormone receptor 0.0277 0.5543 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1421 0.2515
Plasmodium vivax SET domain protein, putative 0.0035 0.0541 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0957 0.1173
Echinococcus granulosus dnaJ subfamily B 0.0404 0.8165 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1421 0.3923
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0036 0.0044

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 umol/L Cytotoxicity against human PC3 cells by resazurin reduction test ChEMBL. 19285391
IC50 (functional) = 13 umol/L Cytotoxicity against human A549 cells by resazurin reduction test ChEMBL. 19285391
IC50 (functional) = 14 umol/L Cytotoxicity against human DLD1 cells by resazurin reduction test ChEMBL. 19285391
IC50 (functional) = 18 umol/L Cytotoxicity against human MCF7 cells by resazurin reduction test ChEMBL. 19285391

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19285391

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.