TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 225.179 | Formula: C7H16NO5P
H donors: 3 H acceptors: 5 LogP: -1.28 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(P(=O)(O)O)CCN(C(=O)C)O
InChi: 1S/C7H16NO5P/c1-3-7(14(11,12)13)4-5-8(10)6(2)9/h7,10H,3-5H2,1-2H3,(H2,11,12,13)
InChiKey: VRKRIEKURSYLLU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	intermediate filament protein	0.006	0.0248	0.1845
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.012	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0039	0.012	0.0907
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.0446	0.3408
Onchocerca volvulus		0.006	0.0248	0.1457
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0153	0.0802	0.0795
Brugia malayi	hypothetical protein	0.0067	0.0289	0.2208
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.012	0.0919
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.012	0.0608
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.0446	0.3366
Brugia malayi	Ets-domain containing protein	0.0075	0.0337	0.2576
Onchocerca volvulus		0.0048	0.0177	0.0888
Schistosoma mansoni	kinase	0.0047	0.0171	0.09
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0055	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Onchocerca volvulus		0.006	0.0248	0.1457
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.0273	0.2039
Loa Loa (eye worm)	CYP4Cod1	0.0027	0.0047	0.0343
Onchocerca volvulus	Huntingtin homolog	0.0132	0.0679	0.4923
Onchocerca volvulus		0.0067	0.0289	0.1784
Leishmania major	hypothetical protein, conserved	0.0039	0.012	0.1846
Brugia malayi	Blistered cuticle protein 3	0.0067	0.0289	0.2208
Mycobacterium ulcerans	lipase LipD	0.0039	0.012	0.0249
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.0359	0.1976
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0047	0.0343
Brugia malayi	Melibiase family protein	0.0079	0.0359	0.2747
Echinococcus granulosus	lamin dm0	0.006	0.0248	0.1845
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0679	0.5185
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0802	0.6128
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0047	0.0343
Brugia malayi	hypothetical protein	0.0132	0.0679	0.5192
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0164	0.0367
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.006	0.0401
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0062	0.038
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0203	0.1102	0.8415
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0075	0.0337	0.2566
Onchocerca volvulus		0.0153	0.0802	0.5913
Brugia malayi	Trypsin family protein	0.0153	0.0802	0.6133
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0446	1
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0153	0.0802	0.6109
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0177	0.0933
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.0359	0.1976
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0047	0.0356
Onchocerca volvulus		0.0153	0.0802	0.5913
Onchocerca volvulus		0.0153	0.0802	0.5913
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0105	0.0518
Schistosoma mansoni	gabp alpha	0.0075	0.0337	0.1848
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.012	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0802	0.6128
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0802	0.6128
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1308	1
Brugia malayi	Animal haem peroxidase family protein	0.0067	0.0289	0.2208
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0062	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Schistosoma mansoni	intermediate filament proteins	0.006	0.0248	0.1339
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0446	0.2735
Echinococcus granulosus	GA binding protein alpha chain	0.0075	0.0337	0.2529
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.4512
Onchocerca volvulus		0.0067	0.0289	0.1784
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.0446	0.3399
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.4512
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Echinococcus multilocularis	peroxidasin	0.0067	0.0289	0.0281
Onchocerca volvulus		0.0237	0.1311	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0033	0.0025
Loa Loa (eye worm)	MBCTL1	0.0059	0.0239	0.1812
Onchocerca volvulus		0.0039	0.012	0.0429
Echinococcus granulosus	lamin	0.006	0.0248	0.1845
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.052	0.3004	1
Brugia malayi	Trypsin family protein	0.0153	0.0802	0.6133
Brugia malayi	Animal haem peroxidase family protein	0.0067	0.0289	0.2208
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0359	0.2737
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.012	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0039	0.012	0.0907
Schistosoma mansoni	hypothetical protein	0.0153	0.0802	0.4512
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0177	0.0933
Loa Loa (eye worm)	animal heme peroxidase	0.0067	0.0289	0.2198
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Schistosoma mansoni	hypothetical protein	0.0022	0.0021	0.0039
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0021	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0272	0.2067
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Loa Loa (eye worm)	hypothetical protein	0.0039	0.012	0.0907
Echinococcus multilocularis	zinc finger protein	0.0021	0.0014	0.0006
Brugia malayi	Trypsin-like protease protein 5	0.0153	0.0802	0.6133
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.0239	0.1823
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0203	0.1102	0.1095
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0446	0.2735
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0067	0.0302
Giardia lamblia	Kinase, PLK	0.0093	0.0446	0.5
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.0239	0.1771
Echinococcus granulosus	geminin	0.0172	0.0917	0.6987
Schistosoma mansoni	peroxidasin	0.0067	0.0289	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Onchocerca volvulus		0.0039	0.012	0.0429
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0062	0.0458
Schistosoma mansoni	ets-related	0.0228	0.1252	0.7085
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.0446	0.2471
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Brugia malayi	Bromodomain containing protein	0.0081	0.0372	0.2845
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0032	0.0081	0.0605
Brugia malayi	Trypsin family protein	0.0153	0.0802	0.6133
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.3004	0.5
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0177	0.1356
Brugia malayi	PHD-finger family protein	0.0027	0.0049	0.0371
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.3004	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0051	0.0196	0.104
Echinococcus granulosus	lysine specific demethylase 5A	0.007	0.0306	0.2292
Brugia malayi	jmjC domain containing protein	0.0068	0.0294	0.2246
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0248	0.1374	1
Onchocerca volvulus	Peroxidasin homolog	0.0067	0.0289	0.1784
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.0125	0.0637	0.4122
Loa Loa (eye worm)	animal heme peroxidase	0.0067	0.0289	0.2198
Brugia malayi	Cytochrome P450 family protein	0.0056	0.0223	0.1706
Brugia malayi	Trypsin family protein	0.0153	0.0802	0.6133
Echinococcus multilocularis	polycomb protein SCMH1	0.0051	0.0196	0.0188
Echinococcus multilocularis	lamin	0.006	0.0248	0.024
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.012	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0039	0.012	0.0907
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0177	0.1299
Onchocerca volvulus	Chorion peroxidase homolog	0.0067	0.0289	0.1784
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.4512
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.012	0.0861
Loa Loa (eye worm)	trypsin family protein	0.0153	0.0802	0.6128
Onchocerca volvulus	Dual oxidase homolog	0.0067	0.0289	0.1784
Echinococcus granulosus	enteropeptidase	0.0153	0.0802	0.6109
Mycobacterium ulcerans	beta-lactamase	0.0039	0.012	0.0249
Onchocerca volvulus	Peroxidasin homolog	0.0067	0.0289	0.1784
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Onchocerca volvulus		0.0153	0.0802	0.5913
Schistosoma mansoni	jumonji domain containing protein	0.0068	0.0294	0.1601
Onchocerca volvulus	Peroxidase homolog	0.0067	0.0289	0.1784
Onchocerca volvulus		0.0153	0.0802	0.5913
Schistosoma mansoni	hypothetical protein	0.0172	0.0917	0.5165
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.012	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0039	0.012	0.0907
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0067	0.0302
Echinococcus multilocularis	geminin	0.0172	0.0917	0.0909
Plasmodium vivax	SET domain protein, putative	0.003	0.0067	0.0018
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.012	0.0112
Loa Loa (eye worm)	cytochrome P450 family protein	0.0056	0.0223	0.1695
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.1311	1
Loa Loa (eye worm)	animal heme peroxidase	0.0067	0.0289	0.2198
Brugia malayi	hypothetical protein	0.0153	0.0802	0.6133
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0062	0.038
Loa Loa (eye worm)	blistered cuticle protein 3	0.0067	0.0289	0.2198
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0446	0.2735
Schistosoma mansoni	jumonji/arid domain-containing protein	0.007	0.0306	0.1672
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0079	0.0359	0.2009
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.012	0.0199
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0446	0.2735
Echinococcus granulosus	zinc finger protein	0.0021	0.0014	0.0045
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.1308	1
Schistosoma mansoni	bromodomain containing protein	0.0068	0.0297	0.1616
Toxoplasma gondii	ABC1 family protein	0.0039	0.012	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0802	0.6128
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Echinococcus multilocularis	lamin dm0	0.006	0.0248	0.024
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0446	0.2735
Brugia malayi	Fli-1 protein	0.0228	0.1252	0.957
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.0446	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Echinococcus granulosus	polycomb protein SCMH1	0.0051	0.0196	0.1443
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0029	0.0062	0.041
Brugia malayi	Peroxidasin	0.0067	0.0289	0.2208
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0177	0.1342
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.1308	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0055	0.0408
Schistosoma mansoni	hypothetical protein	0.0048	0.0177	0.0935
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0595	0.3325
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.3004	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.4512
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.3004	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.0795
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.006	0.0248	0.1886
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0242	0.1835
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0105	0.0741
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0153	0.0802	0.6133
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0029	0.0062	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0039	0.012	0.0907
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.4512
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0118	0.0595	0.0587
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.0239	0.1771
Brugia malayi	hypothetical protein	0.0237	0.1308	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0802	0.6128
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.4512
Echinococcus multilocularis	transmembrane protease serine 3	0.0153	0.0802	0.0795
Onchocerca volvulus		0.0051	0.0196	0.1036
Echinococcus multilocularis	GA binding protein alpha chain	0.0075	0.0337	0.0329
Onchocerca volvulus		0.0067	0.0289	0.1784
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0118	0.0595	0.4514
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0595	0.3325
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0446	0.2735
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0153	0.0802	0.6109
Brugia malayi	hypothetical protein	0.0036	0.0105	0.08
Brugia malayi	Pre-SET motif family protein	0.003	0.0067	0.0512
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0105	0.0096
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.3004	0.5
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.0239	0.023
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0153	0.0802	0.4512
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0177	0.0935
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0033	0.011
Loa Loa (eye worm)	beta-lactamase	0.0039	0.012	0.0907
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0067	0.0059
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Echinococcus granulosus	transmembrane protease serine 3	0.0153	0.0802	0.6109
Brugia malayi	mbt repeat family protein	0.0051	0.0196	0.1497
Brugia malayi	hypothetical protein	0.0029	0.0062	0.0472
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0595	0.3325
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0196	0.104
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.0239	0.1284
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0118	0.0595	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0802	0.6128
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0047	0.0356
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0068	0.0294	0.0286
Mycobacterium ulcerans	hypothetical protein	0.0153	0.0802	0.2556
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.3004	0.5
Onchocerca volvulus	Huntingtin homolog	0.0132	0.0679	0.4923
Echinococcus granulosus	SAM and MBT domain containing protein	0.0051	0.0196	0.1443
Mycobacterium ulcerans	hypothetical protein	0.0039	0.012	0.0249
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.012	0.0858
Schistosoma mansoni	hypothetical protein	0.0036	0.0105	0.0518
Brugia malayi	intermediate filament protein	0.006	0.0248	0.1897
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0136	0.1024
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.0446	0.0438
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0067	0.0018
Loa Loa (eye worm)	intermediate filament protein	0.006	0.0248	0.1886
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.0306	0.233
Brugia malayi	mbt repeat family protein	0.0051	0.0196	0.1497
Onchocerca volvulus	Peroxidase homolog	0.0067	0.0289	0.1784
Brugia malayi	Bromodomain containing protein	0.0041	0.0135	0.1032
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.012	0.0608
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0177	0.0169
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0068	0.0294	0.2197
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.0239	0.023
Brugia malayi	beta-lactamase family protein	0.0039	0.012	0.0919
Brugia malayi	cytoplasmic intermediate filament protein	0.0032	0.0081	0.0617
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0446	0.2735
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0446	1
Schistosoma mansoni	hypothetical protein	0.0172	0.0917	0.5165
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.012	0.0907
Schistosoma mansoni	jumonji/arid domain-containing protein	0.007	0.0306	0.1672
Echinococcus granulosus	glycoprotein Antigen 5	0.0153	0.0802	0.6109
Loa Loa (eye worm)	mbt repeat family protein	0.0051	0.0196	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0802	0.6128
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.3004	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0051	0.0196	0.1036
Echinococcus multilocularis	enteropeptidase	0.0153	0.0802	0.0795
Brugia malayi	jmjC domain containing protein	0.007	0.0306	0.234
Schistosoma mansoni	lamin	0.006	0.0248	0.1339
Brugia malayi	Intermediate filament tail domain containing protein	0.006	0.0248	0.1897
Brugia malayi	Ets-domain containing protein	0.0075	0.0337	0.2576
Echinococcus granulosus	Mastin	0.0153	0.0802	0.6109
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.0446	0.3047
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.1138	0.8696
Echinococcus multilocularis	lysine specific demethylase 5A	0.0068	0.0294	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0345	0.2624
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.0273	0.0265
Loa Loa (eye worm)	hypothetical protein	0.006	0.0248	0.1886
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0163	0.1236
Leishmania major	hypothetical protein, conserved	0.0029	0.0062	0.038
Schistosoma mansoni	hypothetical protein	0.0153	0.0802	0.4512
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0051	0.0196	0.0188
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0062	0.038
Echinococcus multilocularis	musashi	0.006	0.0248	0.024
Echinococcus multilocularis	Mastin	0.0153	0.0802	0.0795
Brugia malayi	Animal haem peroxidase family protein	0.0067	0.0289	0.2208
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.0446	1
Brugia malayi	Animal haem peroxidase family protein	0.0067	0.0289	0.2208
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0239	0.1812
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.0595	0.3325
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0679	0.5185
Loa Loa (eye worm)	fli-1 protein	0.0228	0.1252	0.9569
Schistosoma mansoni	hypothetical protein	0.0313	0.1761	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0151	0.1141
Onchocerca volvulus		0.0039	0.012	0.0429
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0196	0.104
Loa Loa (eye worm)	animal heme peroxidase	0.0067	0.0289	0.2198
Toxoplasma gondii	melibiase subfamily protein	0.0118	0.0595	0.1813
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0033	0.0192
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0153	0.0802	0.4512
Schistosoma mansoni	peroxidasin	0.0067	0.0289	0.1573
Brugia malayi	Pre-SET motif family protein	0.0209	0.1138	0.8698
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0196	0.1485
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.012	0.1846
Schistosoma mansoni	lamin	0.006	0.0248	0.1339
Schistosoma mansoni	cercarial elastase (S01 family)	0.0153	0.0802	0.4512
Echinococcus multilocularis	glycoprotein Antigen 5	0.0153	0.0802	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Onchocerca volvulus		0.0153	0.0802	0.5913
Brugia malayi	beta-lactamase family protein	0.0039	0.012	0.0919
Trypanosoma brucei	polo-like protein kinase	0.0093	0.0446	1
Echinococcus granulosus	peroxidasin	0.0067	0.0289	0.2158
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0164	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0289	0.2198
Brugia malayi	beta-lactamase	0.0039	0.012	0.0919
Brugia malayi	Animal haem peroxidase family protein	0.0067	0.0289	0.2208

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= -6.15	Inhibitory concentration against DOXP reductoisomerase	ChEMBL.	15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL607413

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1185112