Detailed information for compound 1189511

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 110.049 | Formula: C2H7O3P
  • H donors: 1 H acceptors: 2 LogP: 0.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=O)O
  • InChi: 1S/C2H7O3P/c1-2-5-6(3)4/h6H,2H2,1H3,(H,3,4)
  • InChiKey: VUERQRKTYBIULR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutaminase 0.0318 0.3223 0.3223
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0264 0.2375
Plasmodium vivax SET domain protein, putative 0.003 0.0225 0.2025
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.034 0.045
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0083 0.0786 0.0786
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0083 0.0786 0.0786
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1105 0.1105
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.1105 0.1469
Leishmania major pyruvate kinase 0.0033 0.0264 0.2375
Echinococcus multilocularis inositol monophosphatase 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0004
Echinococcus multilocularis musashi 0.0031 0.0238 0.0238
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0264 0.2375
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis pyruvate kinase 0.0033 0.0264 0.0264
Echinococcus granulosus intermediate filament protein 0.0031 0.0238 0.0238
Schistosoma mansoni cpg binding protein 0.003 0.0224 0.0224
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0511 0.0509
Brugia malayi intermediate filament protein 0.0031 0.0238 0.0236
Trypanosoma cruzi GUP1, putative 0.0083 0.0786 0.7102
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0083 0.0786 0.7102
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Echinococcus multilocularis pyruvate kinase 0.0026 0.0191 0.0191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.034 0.034
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Leishmania major pyruvate kinase 0.0033 0.0264 0.2375
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0082 0.0774 0.2386
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.034 0.3063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.034 0.3063
Loa Loa (eye worm) hypothetical protein 0.0105 0.1006 0.1005
Echinococcus multilocularis microtubule associated protein 2 0.0791 0.8147 0.8147
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0108 0.0108
Schistosoma mansoni ap endonuclease 0.0041 0.034 0.034
Trypanosoma brucei glycerol uptake protein, putative 0.0083 0.0786 0.7102
Onchocerca volvulus 0.003 0.0225 0.0962
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0238 0.0236
Echinococcus multilocularis muscleblind protein 0.0649 0.6675 0.6675
Loa Loa (eye worm) MBOAT family protein 0.0083 0.0786 0.0784
Mycobacterium ulcerans hypothetical protein 0.0114 0.1105 0.3416
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0969 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0264 0.0262
Loa Loa (eye worm) MBOAT family protein 0.0969 1 1
Leishmania major myo-inositol-1 phosphatase, putative 0.0009 0.0006 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0323 0.0321
Echinococcus granulosus microtubule associated protein 2 0.0791 0.8147 0.8147
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0264 0.0262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0208 0.0208
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0072 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0606 0.1865
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0009 0.0009
Mycobacterium ulcerans glutaminase 0.0318 0.3223 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0095 0.0095
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0108 0.0957
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1441 0.1441
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2324 0.7208
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4062 0.4062
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0089 0.0087
Schistosoma mansoni zinc finger protein 0.0969 1 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1441 0.1441
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0006
Echinococcus multilocularis zinc finger protein 0.0885 0.9131 0.9131
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2032 0.2031
Schistosoma mansoni apoferritin-2 0.001 0.0018 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.034 0.0338
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0105 0.0103
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0006
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0009 0.0006 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0774 0.2396
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1105 0.3425
Trichomonas vaginalis inositol monophosphatase, putative 0.0009 0.0006 0.0014
Giardia lamblia Hypothetical protein 0.0009 0.0006 0.0129
Mycobacterium tuberculosis Probable monophosphatase 0.0009 0.0006 0.0006
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0498 0.0498
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0225 0.0225
Schistosoma mansoni myo inositol monophosphatase 0.0009 0.0006 0.0006
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0083 0.0786 0.0786
Trichomonas vaginalis glutaminase, putative 0.0318 0.3223 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0264 0.0264
Echinococcus multilocularis ferritin 0.001 0.0018 0.0018
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0017 0.0015
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.1006 0.1006
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0264 0.2375
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0018 0.0103
Onchocerca volvulus 0.0231 0.2324 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0498 0.0496
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.034 0.3063
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0009 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0786 0.2432
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.1105 0.3416
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Mycobacterium ulcerans beta-lactamase 0.0114 0.1105 0.3416
Echinococcus granulosus zinc finger protein 0.0885 0.9131 0.9131
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.034 0.1037
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0002 0.0002
Schistosoma mansoni intermediate filament proteins 0.0031 0.0238 0.0238
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0108 0.0957
Echinococcus granulosus o acyltransferase membrane bound domain 0.0083 0.0786 0.0786
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.034 0.034
Brugia malayi MH2 domain containing protein 0.0009 0.0009 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.1105 0.3416
Schistosoma mansoni pyruvate kinase 0.0033 0.0264 0.0264
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0545 0.0545
Echinococcus granulosus neuropeptide s receptor 0.0451 0.4611 0.4611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1441 0.1441
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0083 0.0786 1
Brugia malayi beta-lactamase 0.0114 0.1105 0.1103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0225 0.0225
Schistosoma mansoni hypothetical protein 0.0194 0.1938 0.1938
Mycobacterium leprae conserved hypothetical protein 0.0114 0.1105 1
Echinococcus multilocularis synaptojanin 1 0.0008 0.0002 0.0002
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0002 0.0002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0498 0.066
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0083 0.0786 0.0786
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.4611 0.4611
Brugia malayi hypothetical protein 0.0083 0.0777 0.0775
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.1441 0.1439
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0264 0.0801
Schistosoma mansoni smad 0.0009 0.0009 0.0009
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0108 0.0957
Toxoplasma gondii ABC1 family protein 0.0114 0.1105 1
Onchocerca volvulus 0.0105 0.1006 0.4326
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0223
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.1105 0.1469
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0108 0.0106
Echinococcus multilocularis geminin 0.0194 0.1938 0.1938
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0002 0.0002
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0264 0.0814
Schistosoma mansoni ferritin light chain 0.001 0.0018 0.0018
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0002
Schistosoma mansoni lamin 0.0031 0.0238 0.0238
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0083 0.0786 0.0786
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0264 0.0814
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0083 0.0786 0.0786
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.2742 0.274
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.034 0.0338
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.034 0.4312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0225 0.0225
Trichomonas vaginalis inositol monophosphatase, putative 0.0009 0.0006 0.0014
Mycobacterium ulcerans lipase LipD 0.0114 0.1105 0.3416
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.1105 0.1469
Schistosoma mansoni microtubule-associated protein tau 0.0791 0.8147 0.8147
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0606 0.0606
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0095 0.0842
Loa Loa (eye worm) inositol-1 0.0082 0.0774 0.0772
Brugia malayi Muscleblind-like protein 0.0649 0.6675 0.6674
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0009 0.0006 0.004
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0498 0.0498
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0083 0.0786 0.0786
Brugia malayi MH2 domain containing protein 0.013 0.1266 0.1264
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0498 0.1528
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0018 0.0021
Echinococcus granulosus o acyltransferase membrane bound domain 0.0083 0.0786 0.0786
Echinococcus multilocularis muscleblind protein 1 0.0649 0.6675 0.6675
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0089 0.0087
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0264 0.2345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Echinococcus granulosus inositol monophosphatase 1 0.0082 0.0774 0.0774
Echinococcus multilocularis Smad4 0.0009 0.0009 0.0009
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0083 0.0786 1
Schistosoma mansoni cpg binding protein 0.0028 0.0208 0.0208
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Leishmania major hypothetical protein, conserved 0.0114 0.1105 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0083 0.0786 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0082 0.0774 0.9851
Loa Loa (eye worm) hypothetical protein 0.0014 0.0066 0.0064
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0264 0.2375
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Loa Loa (eye worm) beta-lactamase 0.0114 0.1105 0.1103
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Brugia malayi Pre-SET motif family protein 0.0203 0.2032 0.2031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0105 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.1105 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0232 0.023
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Echinococcus granulosus o acyltransferase membrane bound domain 0.0083 0.0786 0.0786
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0606 0.1865
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Schistosoma mansoni cpg binding protein 0.003 0.0224 0.0224
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.0009
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0083 0.0786 0.0786
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.034 0.3063
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0264 0.2375
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.0009
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0018 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1105 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.034 0.3063
Brugia malayi Pre-SET motif family protein 0.003 0.0225 0.0223
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.1105 0.1469
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0066 0.0064
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0108 0.0957
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Schistosoma mansoni Smad4 0.0009 0.0009 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0606 0.0606
Schistosoma mansoni transcription factor LCR-F1 0.0083 0.0777 0.0777
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.034 0.1049
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0009 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0072 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1105 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0083 0.0786 1
Mycobacterium tuberculosis Conserved protein 0.0114 0.1105 0.1469
Loa Loa (eye worm) glutaminase 0.0318 0.3223 0.3222
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.1105 0.1105
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1266 0.1264
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0606 0.0606
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0105 0.0103
Schistosoma mansoni inositol monophosphatase 0.0082 0.0774 0.0774
Brugia malayi MH2 domain containing protein 0.0009 0.0009 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0105 0.0105
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0083 0.0786 0.0784
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0105 0.0105
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0108 0.0108
Echinococcus multilocularis sterol O acyltransferase 1 0.0083 0.0786 0.0786
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0018 0.02
Echinococcus granulosus cpg binding protein 0.003 0.0224 0.0224
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.034 0.1049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.073 0.7511 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0074 0.0684 0.6166
Onchocerca volvulus 0.0083 0.0786 0.3375
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0649 0.6675 0.6674
Echinococcus granulosus GPCR family 2 0.0018 0.0105 0.0105
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.4611 0.4611
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0264 0.1129
Onchocerca volvulus 0.0028 0.0208 0.0886
Schistosoma mansoni apoferritin-2 0.001 0.0018 0.0018
Treponema pallidum alginate O-acetylation protein (algI) 0.0083 0.0786 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1441 0.1441
Schistosoma mansoni inositol monophosphatase 0.0082 0.0774 0.0774
Brugia malayi Smad1 0.0009 0.0009 0.0006
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0002 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0606 0.5476
Loa Loa (eye worm) hhat protein 0.0083 0.0786 0.0784
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0108 0.0957
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4062 0.4062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Brugia malayi diacylglycerol acyltransferase 0.0083 0.0786 0.0784
Loa Loa (eye worm) MBOAT family protein 0.0083 0.0786 0.0784
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1266 0.1264
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0511 0.0509
Loa Loa (eye worm) histone methyltransferase 0.001 0.0018 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0105 0.0105
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0264 0.0262
Trichomonas vaginalis esterase, putative 0.0114 0.1105 0.3425
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0083 0.0786 0.0786
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0009 0.0009
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0238 0.0236
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0264 0.0349
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0108 0.0957
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0498 0.1528
Echinococcus granulosus smad 0.0009 0.0009 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0264 0.0262
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0606 0.0606
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0083 0.0786 0.0784
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0225 0.0225
Echinococcus multilocularis lamin dm0 0.0031 0.0238 0.0238
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0108 0.0141
Leishmania major hypothetical protein, conserved 0.0083 0.0786 0.7102
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0002 0.0002
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0002 0.0002
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1105 0.3425
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Mycobacterium tuberculosis Monophosphatase CysQ 0.0009 0.0006 0.0006
Brugia malayi beta-lactamase family protein 0.0114 0.1105 0.1103
Schistosoma mansoni pap-inositol-14-phosphatase 0.0009 0.0006 0.0006
Chlamydia trachomatis pyruvate kinase 0.0033 0.0264 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Echinococcus granulosus inositol monophosphatase 0.0009 0.0006 0.0006
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0009 0.0006 0.004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0108 0.1348
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0009 0.0006 0.0056
Brugia malayi Inositol monophosphatase family protein 0.0009 0.0006 0.0004
Brugia malayi beta-lactamase family protein 0.0114 0.1105 0.1103
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0095 0.1186
Onchocerca volvulus 0.0114 0.1105 0.4752
Brugia malayi Inositol-1 0.0082 0.0774 0.0772
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.1441 0.1439
Onchocerca volvulus 0.0031 0.0238 0.1017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0208 0.0206
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.1105 0.1469
Onchocerca volvulus 0.0031 0.0238 0.1017
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0018 0.0035
Echinococcus granulosus expressed protein 0.001 0.0018 0.0018
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0009 0.0006 0.004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0459 0.0457
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0083 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0002
Onchocerca volvulus 0.0114 0.1105 0.4752
Schistosoma mansoni hypothetical protein 0.0083 0.0786 0.0786
Trypanosoma brucei glycerol uptake protein, putative 0.0083 0.0786 0.7102
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0264 0.1129
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Trypanosoma cruzi glycerol uptake protein, putative 0.0083 0.0786 0.7102
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.034 0.4261
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.1105 0.1469
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.034 0.4312
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.1105 0.1105
Entamoeba histolytica hypothetical protein, conserved 0.0083 0.0786 1
Echinococcus multilocularis expressed protein 0.001 0.0018 0.0018
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Trichomonas vaginalis inositol monophosphatase, putative 0.0082 0.0774 0.2396
Brugia malayi Inositol monophosphatase family protein 0.0009 0.0006 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0479 0.4325
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0225 0.2025
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.1105 0.1103
Echinococcus granulosus Smad4 0.0009 0.0009 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0606 0.5476
Schistosoma mansoni ferritin light chain 0.001 0.0018 0.0018
Trypanosoma cruzi GUP1, putative 0.0083 0.0786 0.7102
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0083 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.0236
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0083 0.0786 0.0786
Echinococcus granulosus pyruvate kinase 0.0033 0.0264 0.0264
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0022 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0083 0.0777 0.0777
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0969 1 1
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0264 0.0262
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0225 0.0225
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.4611 0.4611
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0264 0.2375
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0498 0.4494
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0264 0.0262
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.034 0.4312
Schistosoma mansoni nocturnin 0.0008 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1441 0.1441
Schistosoma mansoni hypothetical protein 0.0398 0.4062 0.4062
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0009 0.0009
Echinococcus granulosus synaptojanin 1 0.0008 0.0002 0.0002
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0083 0.0786 0.7102
Echinococcus multilocularis inositol monophosphatase 1 0.0082 0.0774 0.0774
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0095 0.0842
Mycobacterium tuberculosis Conserved protein 0.0114 0.1105 0.1469
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0002 0.0002
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.0009 0.0006 0.004
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0002
Echinococcus granulosus sterol O acyltransferase 1 0.0083 0.0786 0.0786
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0511 0.0509
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0498 0.0498
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0009 0.0006 0.0006
Onchocerca volvulus 0.0114 0.1105 0.4752
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0083 0.0777 0.0777
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0606 0.1865
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0774 0.2396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1441 0.1441
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0264 0.1129
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1105 0.3425
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0105 0.0103
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1105 0.3425
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.034 1
Loa Loa (eye worm) Smad1 0.0009 0.0009 0.0006
Entamoeba histolytica hypothetical protein 0.0083 0.0786 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0108 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1441 0.1441
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0083 0.0786 0.0786
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0074 0.0684 0.0908
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0018 0.0021
Brugia malayi glutaminase DH11.1 0.0318 0.3223 0.3222
Echinococcus multilocularis cpg binding protein 0.003 0.0224 0.0224
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0083 0.0786 0.7102
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1105 1
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.1105 0.1469
Loa Loa (eye worm) hypothetical protein 0.0018 0.0105 0.0103
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0009 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0039 0.0323 0.0323
Brugia malayi Hhat protein 0.0083 0.0786 0.0784
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0083 0.0786 0.0786
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0083 0.0777 0.0777
Echinococcus granulosus ferritin 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0323 0.0321
Mycobacterium tuberculosis Conserved protein 0.0114 0.1105 0.1469
Loa Loa (eye worm) hypothetical protein 0.0057 0.0511 0.0509
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0002 0.0002
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0159 0.2003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0009 0.0006 0.0014
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0159 0.0157
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0083 0.0786 0.0786
Echinococcus multilocularis pyruvate kinase 0.0033 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Toxoplasma gondii exonuclease III APE 0.0041 0.034 0.3063
Schistosoma mansoni lamin 0.0031 0.0238 0.0238
Echinococcus multilocularis lamin 0.0031 0.0238 0.0238
Mycobacterium leprae Probable lipase LipE 0.0114 0.1105 1
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0009 0.0006 0.004
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Trypanosoma cruzi glycerol uptake protein, putative 0.0083 0.0786 0.7102
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0606 0.0805
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0002 0.0002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0082 0.0774 0.6996
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0072 0.0072
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0108 0.0957
Echinococcus granulosus lamin 0.0031 0.0238 0.0238
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Echinococcus multilocularis tumor protein p63 0.0715 0.7362 0.7362
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Brugia malayi CXXC zinc finger family protein 0.0028 0.0208 0.0206
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0157
Giardia lamblia Pyruvate kinase 0.0033 0.0264 0.7756
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.1105 0.1103
Brugia malayi follicle stimulating hormone receptor 0.0271 0.2742 0.274
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0786 0.2432
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0225 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1105 0.1105
Trichomonas vaginalis ferritin, putative 0.001 0.0018 0.0049
Loa Loa (eye worm) glutaminase 2 0.0318 0.3223 0.3222
Echinococcus granulosus lamin dm0 0.0031 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0649 0.6675 0.6674
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1105 0.3425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0225 0.0225
Loa Loa (eye worm) hhat protein 0.0083 0.0786 0.0784
Echinococcus granulosus muscleblind protein 0.0649 0.6675 0.6675
Schistosoma mansoni sterol O-acyltransferase 1 0.0083 0.0786 0.0786
Echinococcus multilocularis smad 0.0009 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0082 0.0774 1
Schistosoma mansoni hypothetical protein 0.0194 0.1938 0.1938
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0002
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Toxoplasma gondii hypothetical protein 0.0083 0.0786 0.7102
Plasmodium falciparum pyruvate kinase 0.0033 0.0264 0.3345
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0108 0.0957
Giardia lamblia Pyruvate kinase 0.0017 0.0095 0.275
Schistosoma mansoni cript-related 0.0008 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0786 0.2432
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0108 0.0108
Echinococcus granulosus geminin 0.0194 0.1938 0.1938
Trichomonas vaginalis transmembrane protein nessy, putative 0.0083 0.0786 0.2432
Trichomonas vaginalis porcupine, putative 0.0083 0.0786 0.2432
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0238 0.0236
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Trypanosoma cruzi glycerol uptake protein, putative 0.0083 0.0786 0.7102
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0083 0.0786 0.0786
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0009 0.0006 0.0056
Entamoeba histolytica vacuolar protein sorting 26 0.0083 0.0786 1
Schistosoma mansoni ap endonuclease 0.0041 0.034 0.034
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0009 0.0006 0.0014
Schistosoma mansoni pyruvate kinase 0.0033 0.0264 0.0264
Echinococcus granulosus tumor protein p63 0.0715 0.7362 0.7362
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0083 0.0786 0.0786

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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