Detailed information for compound 1190159

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.523 | Formula: C27H29NO4
  • H donors: 1 H acceptors: 0 LogP: 6.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC1OCC2(OO1)CCC(CC2)C(=C)c1ccc2c(c1)cccc2
  • InChi: 1S/C27H29NO4/c1-19(22-8-7-21-5-3-4-6-23(21)17-22)20-13-15-27(16-14-20)18-30-26(31-32-27)28-24-9-11-25(29-2)12-10-24/h3-12,17,20,26,28H,1,13-16,18H2,2H3
  • InChiKey: NZDQABIZAVQWPS-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0415 0.0411
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0409 0.0405
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0153 0.0496
Schistosoma mansoni ferritin 0.0009 0.0022 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0005 0.0001
Echinococcus granulosus voltage dependent calcium channel 0.002 0.0104 0.01
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0134 0.0134
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0005 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0262 1
Loa Loa (eye worm) Smad1 0.0027 0.0153 0.0496
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.002 0.0104 0.0333
Schistosoma mansoni ferritin light chain 0.0009 0.0022 0.0018
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0262 0.0884
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0027 0.0867
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.3083 0.308
Brugia malayi voltage-dependent calcium channel 0.002 0.0104 0.0342
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0104 0.01
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0104 0.01
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0027 0.0867
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.002 0.0104 0.0342
Echinococcus granulosus expressed conserved protein 0.0094 0.0668 0.0664
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0008 0.0013 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0134 0.0134
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0088 0.0086
Echinococcus multilocularis synaptojanin 1 0.0008 0.0013 0.0009
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0013 0.0475
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0104 0.0103
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0278 0.0274
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0278 0.0914
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0075
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0022 0.0018
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0022 0.0018
Echinococcus granulosus transient receptor potential gamma protein 0.0401 0.3001 0.2998
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Echinococcus granulosus mothers against decapentaplegic 6 0.0012 0.0041 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0442 0.0438
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0262 0.0862
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0278 0.0274
Loa Loa (eye worm) hypothetical protein 0.0101 0.0715 0.237
Echinococcus granulosus nibrin 0.001 0.0027 0.0022
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0008 0.0013 0.0348
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0715 0.2433
Echinococcus granulosus SWI:SNF matrix associated 0.0012 0.0041 0.0036
Schistosoma mansoni topbp1 0.001 0.0027 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0206 0.0202
Echinococcus granulosus transient receptor potential ion channel A 0.0381 0.2848 0.2845
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Brugia malayi RNA binding protein 0.0065 0.0442 0.15
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.0104 0.01
Schistosoma mansoni cript-related 0.0008 0.0013 0.0009
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0012 0.0041 0.1408
Echinococcus multilocularis expressed conserved protein 0.0094 0.0668 0.0664
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Echinococcus granulosus voltage gated potassium channel 0.002 0.0104 0.01
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0013 0.0348
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1283 0.97 1
Brugia malayi olfactory channel protein osm-9 0.002 0.0104 0.0342
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0104 0.0342
Schistosoma mansoni vesicular amine transporter 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Leishmania major hypothetical protein, conserved 0.0008 0.0013 0.0219
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0104 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0758 0.2583
Loa Loa (eye worm) ion channel NompC 0.002 0.0104 0.0333
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0009
Echinococcus multilocularis expressed protein 0.0009 0.0022 0.0018
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.3171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0417 0.0413
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0262 0.3635
Schistosoma mansoni hypothetical protein 0.0034 0.0206 0.0202
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0278 0.0274
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.002 0.0104 0.0342
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0415 0.0411
Echinococcus granulosus Smad4 0.0027 0.0153 0.0149
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0104 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.1043 0.1039
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0415 0.0411
Loa Loa (eye worm) hypothetical protein 0.0043 0.0278 0.0914
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Schistosoma mansoni survival motor neuron protein 0.0049 0.0325 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0134 0.0445
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0409 0.0405
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0262 0.0266
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0008 0.0013 0.0127
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0104 0.01
Echinococcus multilocularis conserved hypothetical protein 0.002 0.0104 0.01
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0104 0.01
Chlamydia trachomatis SWIB complex protein 0.0012 0.0041 0.2285
Echinococcus multilocularis cpg binding protein 0.0031 0.0183 0.0179
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Schistosoma mansoni voltage-dependent calcium channel 0.002 0.0104 0.01
Echinococcus multilocularis transient receptor potential gamma protein 0.0401 0.3001 0.2998
Schistosoma mansoni nocturnin 0.0008 0.0013 0.0009
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Schistosoma mansoni smad1 5 8 and 0.0027 0.0153 0.0149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0321 0.1057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0279
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.0104 0.01
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0013 0.0348
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Leishmania major hypothetical protein, conserved 0.0008 0.0013 0.0219
Schistosoma mansoni inositol 145-trisphosphate receptor 0.002 0.0104 0.01
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.002 0.0104 0.0342
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0353 0.0349
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0008 0.0013 0.0127
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0075
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0104 0.0333
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0127
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0027 0.0023
Echinococcus multilocularis GPCR, family 2 0.0034 0.0206 0.0202
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0013 0.0348
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0012 0.0041 0.1408
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0027 0.0956
Schistosoma mansoni ferritin 0.0009 0.0022 0.0018
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0104 0.01
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0104 0.3736
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0153 0.0149
Loa Loa (eye worm) MH2 domain-containing protein 0.0391 0.2924 0.9742
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0027 0.0077
Onchocerca volvulus 0.0029 0.017 0.4756
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0262 0.0266
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0041 0.1408
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0262 0.0258
Onchocerca volvulus 0.0012 0.0041 0.1042
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.3171
Echinococcus multilocularis short transient receptor potential channel 6 0.0401 0.3001 0.2998
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0008 0.0013 0.0348
Echinococcus granulosus mothers against decapentaplegic 2 0.0012 0.0041 0.0037
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0104 0.0333
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0104 0.01
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0041 0.0036
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0153 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.0024 0.0134 0.0434
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0104 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0134 0.3164
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0013 0.0009
Schistosoma mansoni two-pore calcium channel 0.002 0.0104 0.01
Schistosoma mansoni DNA ligase IV 0.001 0.0027 0.0022
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0442 0.15
Leishmania major RNA-editing complex protein MP100, putative 0.0008 0.0013 0.0219
Treponema pallidum DNA ligase (lig) 0.001 0.0027 0.0538
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0409 0.0405
Echinococcus granulosus calcium activated potassium channel 0.002 0.0104 0.01
Echinococcus granulosus tar DNA binding protein 0.0065 0.0442 0.0438
Echinococcus granulosus voltage gated hydrogen channel 1 0.002 0.0104 0.01
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0956
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0442 0.0438
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0321 0.0317
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0027 0.0956
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.017 0.0554
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0013 0.0475
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0088 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Echinococcus granulosus microtubule associated protein 2 0.0705 0.5309 0.5307
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0134 0.0434
Loa Loa (eye worm) hypothetical protein 0.0381 0.2848 0.9487
Brugia malayi MH2 domain containing protein 0.0027 0.0153 0.0509
Echinococcus multilocularis transient receptor potential ion channel A 0.0381 0.2848 0.2845
Brugia malayi brahma associated protein 60 kDa 0.0012 0.0041 0.0125
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0153 0.0149
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0104 0.01
Schistosoma mansoni patched 1 0.0043 0.0278 0.0274
Onchocerca volvulus 0.0049 0.0325 0.9186
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0217 0.1601 0.1597
Echinococcus granulosus short transient receptor potential channel 6 0.0401 0.3001 0.2998
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0027 0.0077
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0353 0.0349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0758 0.2583
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0134 0.0134
Brugia malayi hypothetical protein 0.0037 0.023 0.0772
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.002 0.0104 0.01
Brugia malayi mbt repeat family protein 0.0053 0.0353 0.1195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0321 0.0317
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0013 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0104 0.01
Mycobacterium tuberculosis Probable exported protein 0.0008 0.0013 0.0009
Brugia malayi ion channel NompC 0.002 0.0104 0.0342
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0008 0.0013 0.0348
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0104 0.01
Schistosoma mansoni ferritin 0.0009 0.0022 0.0018
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0715 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0104 0.3736
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0415 0.0424
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0013 0.0475
Schistosoma mansoni Smad4 0.0012 0.0041 0.0037
Echinococcus multilocularis TRP (transient receptor potential) channel 0.002 0.0104 0.01
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0012 0.0041 0.0037
Schistosoma mansoni cpg binding protein 0.0029 0.017 0.0166
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0009
Brugia malayi hypothetical protein 0.001 0.0027 0.0077
Schistosoma mansoni synaptojanin 0.0008 0.0013 0.0009
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0104 0.01
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0127
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0013 0.0127
Onchocerca volvulus 0.0053 0.0353 1
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1786 0.1783
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0013 0.0009
Echinococcus multilocularis two pore calcium channel protein 2 0.002 0.0104 0.01
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0442 0.0438
Brugia malayi Transient-receptor-potential like protein 0.002 0.0104 0.0342
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0104 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0956
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0104 0.01
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0013 0.003
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0353 0.0349
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0134 0.0134
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0104 0.01
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0013 0.0475
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0104 0.01
Echinococcus multilocularis mothers against decapentaplegic 2 0.0012 0.0041 0.0037
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0088 0.3234
Schistosoma mansoni calcium-activated potassium channel 0.002 0.0104 0.01
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0013 0.0219
Schistosoma mansoni hypothetical protein 0.0042 0.0266 0.0262
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.002 0.0104 0.0342
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.002 0.0104 0.3863
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0503 0.1707
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0262 1
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0013 0.0009
Toxoplasma gondii pantoate-beta-alanine ligase 0.1283 0.97 1
Schistosoma mansoni Smad4 0.0027 0.0153 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0262 0.9432
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0013 0.0475
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0008 0.0013 0.0127
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0104 0.01
Schistosoma mansoni apoferritin-2 0.0009 0.0022 0.0018
Leishmania major hypothetical protein, conserved 0.002 0.0104 0.2427
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0104 0.01
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Plasmodium falciparum DNase I-like protein, putative 0.0008 0.0013 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0956
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.002 0.0104 0.0342
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.006 0.0409 0.135
Brugia malayi hypothetical protein 0.002 0.0104 0.0342
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Brugia malayi mbt repeat family protein 0.0053 0.0353 0.1195
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0134 0.183
Loa Loa (eye worm) brahma associated protein 0.0012 0.0041 0.0121
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Schistosoma mansoni brg-1 associated factor 0.0012 0.0041 0.0036
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0104 0.01
Onchocerca volvulus Putative neutral sphingomyelinase 0.0008 0.0013 0.0258
Brugia malayi hypothetical protein 0.001 0.0027 0.0077
Toxoplasma gondii hypothetical protein 0.002 0.0104 0.0103
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0088 0.3234
Brugia malayi CXXC zinc finger family protein 0.0029 0.017 0.0568
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0442 0.0438
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0013 0.0348
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0153 0.0496
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0415 0.0424
Brugia malayi MH2 domain containing protein 0.0027 0.0153 0.0509
Trichomonas vaginalis ferritin, putative 0.0009 0.0022 0.0796
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0353 0.1164
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0206 0.0691
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0013 0.0348
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0027 0.0022
Loa Loa (eye worm) RNA binding protein 0.0065 0.0442 0.1461
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0262 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Echinococcus granulosus expressed protein 0.0009 0.0022 0.0018
Schistosoma mansoni ap endonuclease 0.0041 0.0262 0.0258
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0008 0.0013 0.0348
Echinococcus multilocularis short transient receptor potential channel 6 0.1322 1 1
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0104 0.01
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0104 0.01
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0104 0.0333
Chlamydia trachomatis DNA topoisomerase I 0.0012 0.0041 0.2285
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0104 0.01
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.0104 0.01
Schistosoma mansoni hypothetical protein 0.0034 0.0206 0.0202
Echinococcus multilocularis ryanodine receptor 44f 0.002 0.0104 0.01
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.002 0.0104 0.01
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.002 0.0104 0.0342
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.3171
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0012 0.0041 0.0036
Echinococcus multilocularis two pore calcium channel protein 1 0.002 0.0104 0.01
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0409 0.1386
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0022 0.0359
Echinococcus multilocularis geminin 0.0533 0.4003 0.4
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0027 0.0867
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0262 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0206 0.0202
Echinococcus multilocularis voltage gated hydrogen channel 1 0.002 0.0104 0.01
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.002 0.0104 0.01
Echinococcus granulosus GPCR family 2 0.0034 0.0206 0.0202
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0041 0.0122
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0013 0.0348
Schistosoma mansoni ryanodine receptor related 0.002 0.0104 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0134 0.0134
Schistosoma mansoni ferritin light chain 0.0009 0.0022 0.0018
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0008 0.0013 0.0348
Schistosoma mansoni hypothetical protein 0.0412 0.3083 0.308
Schistosoma mansoni ferritin 0.0009 0.0022 0.0018
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0104 0.0103
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0013 0.0348
Schistosoma mansoni microtubule-associated protein tau 0.0705 0.5309 0.5307
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0041 0.0036
Echinococcus multilocularis protein patched 0.0043 0.0278 0.0274
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.3171
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.002 0.0104 0.0342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0321 0.0317
Schistosoma mansoni hypothetical protein 0.0034 0.0206 0.0202
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.002 0.0104 0.01
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.0104 0.01
Echinococcus multilocularis Smad4 0.0027 0.0153 0.0149
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.002 0.0104 0.0342
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0013 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0134 0.0134
Echinococcus granulosus neuropeptide s receptor 0.048 0.3599 0.3596
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0104 0.01
Echinococcus multilocularis voltage dependent calcium channel 0.002 0.0104 0.01
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0017 0.0045
Loa Loa (eye worm) MBCTL1 0.006 0.0409 0.135
Schistosoma mansoni 60S ribosomal protein L21 0.002 0.0104 0.01
Echinococcus granulosus cpg binding protein 0.0031 0.0183 0.0179
Loa Loa (eye worm) hypothetical protein 0.0401 0.3001 1
Schistosoma mansoni cpg binding protein 0.0031 0.0183 0.0179
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0321 0.0317
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0134 0.0134
Echinococcus granulosus potassium large conductance calcium activated 0.002 0.0104 0.01
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0104 0.01
Brugia malayi topoisomerase 0.001 0.0027 0.0077
Echinococcus granulosus voltage dependent calcium channel 0.002 0.0104 0.01
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Plasmodium vivax exodeoxyribonuclease III, putative 0.0008 0.0013 0.0348
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0104 0.0342
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0321 0.0317
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0027 0.0186
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.002 0.0104 0.01
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0013 0.0009
Echinococcus granulosus short transient receptor potential channel 6 0.1322 1 1
Echinococcus granulosus voltage gated potassium channel 0.002 0.0104 0.01
Brugia malayi MH1 domain containing protein 0.0027 0.0153 0.0509
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1786 0.1783
Echinococcus granulosus synaptojanin 1 0.0008 0.0013 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0013 0.0348
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0104 0.01
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.002 0.0104 0.01
Echinococcus granulosus replication factor c subunit 1 0.001 0.0027 0.0022
Echinococcus granulosus neuropeptide receptor A26 0.048 0.3599 0.3596
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0008 0.0013 0.0348
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0012 0.0041 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.023 0.0225
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Loa Loa (eye worm) ryanodine receptor 0.002 0.0104 0.0333
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0075
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.0104 0.01
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.002 0.0104 0.3863
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0013 0.003
Echinococcus multilocularis smad 0.0027 0.0153 0.0149
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0104 0.01
Toxoplasma gondii exonuclease III APE 0.0041 0.0262 0.0266
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0088 0.0086
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Echinococcus granulosus ferritin 0.0009 0.0022 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0262 0.9432
Echinococcus granulosus potassium voltage gated channel subfamily C 0.002 0.0104 0.01
Leishmania major endonuclease/exonuclease protein-like protein 0.0008 0.0013 0.0219
Echinococcus multilocularis calcium activated potassium channel 0.002 0.0104 0.01
Schistosoma mansoni hypothetical protein 0.0012 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0278 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0829 0.6247 0.6246
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.002 0.0104 0.01
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0008 0.0013 0.0348
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.0104 0.2859
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0041 0.1458
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0194
Echinococcus multilocularis transfer RNA-Gly 0.002 0.0104 0.01
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0013 0.0475
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0041 0.0122
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0009
Schistosoma mansoni transient receptor potential channel 0.0401 0.3001 0.2998
Onchocerca volvulus 0.002 0.0104 0.2859
Entamoeba histolytica hypothetical protein 0.001 0.0027 0.0315
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0262 1
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0104 0.01
Echinococcus multilocularis protein dispatched 1 0.0049 0.0325 0.0321
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0027 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0206 0.0202
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1283 0.97 1
Echinococcus multilocularis voltage dependent calcium channel 0.002 0.0104 0.01
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.0073 0.0503 0.1663
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0027 0.0023
Schistosoma mansoni hypothetical protein 0.0042 0.0266 0.0262
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0279
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.002 0.0104 0.01
Loa Loa (eye worm) transcription factor SMAD2 0.0391 0.2924 0.9742
Leishmania major hypothetical protein, conserved 0.0008 0.0013 0.0219
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0353 0.0349
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0104 0.0103
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0409 0.0405
Schistosoma mansoni hypothetical protein 0.0073 0.0503 0.0499
Loa Loa (eye worm) hypothetical protein 0.0106 0.0758 0.2516
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0134 0.0445
Loa Loa (eye worm) calcium channel 0.002 0.0104 0.0333
Schistosoma mansoni smad 0.0027 0.0153 0.0149
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.1043 0.1039
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.0104 0.0342
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0134 0.3164
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0013 0.003
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0442 0.0438
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0127
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0008 0.0013 0.0348
Schistosoma mansoni smad 0.0012 0.0041 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.023 0.0225
Leishmania major pantothenate kinase subunit, putative 0.0009 0.0021 0.0401
Onchocerca volvulus 0.0008 0.0013 0.0258
Echinococcus granulosus shaker cognate 0.002 0.0104 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0134 0.3164
Trypanosoma brucei RNA editing exonuclease 2 0.0008 0.0013 0.0348
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.0104 0.01
Schistosoma mansoni hypothetical protein 0.0012 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0013 0.0348
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.008 0.0078
Leishmania major calcium channel protein, putative,ion transporter, putative 0.002 0.0104 0.2427
Brugia malayi MH2 domain containing protein 0.0391 0.2924 1
Schistosoma mansoni topbp1 0.001 0.0027 0.0022
Brugia malayi MH2 domain containing protein 0.0012 0.0041 0.0125
Echinococcus multilocularis shaker cognate 0.002 0.0104 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0027 0.0867
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0153 0.0149
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0279
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0321 0.1085
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0013 0.0475
Schistosoma mansoni hypothetical protein 0.0049 0.0325 0.0321
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0013 0.0009
Schistosoma mansoni hypothetical protein 0.0533 0.4003 0.4
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.0104 0.0342
Schistosoma mansoni smad1 5 8 and 0.0027 0.0153 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.008 0.0078
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0008 0.0013 0.003
Schistosoma mansoni synaptojanin 0.0008 0.0013 0.0009
Schistosoma mansoni hypothetical protein 0.0034 0.0206 0.0202
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0134 0.0134
Brugia malayi cation channel family protein 0.002 0.0104 0.0342
Brugia malayi DKFZp564C0469 protein 0.001 0.0027 0.0077
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.002 0.0104 0.01
Echinococcus multilocularis ferritin 0.0009 0.0022 0.0018
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0104 0.01
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0009 0.0021 0.0639
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.0104 0.2859
Onchocerca volvulus 0.001 0.0027 0.0642
Brugia malayi brahma associated protein 60 kDa 0.0012 0.0041 0.0125
Schistosoma mansoni smad1 5 8 and 0.0027 0.0153 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.008 0.0078
Echinococcus multilocularis sodium channel protein 0.002 0.0104 0.01
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0008 0.0013 0.0219
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0367 0.0374
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.002 0.0104 0.0342
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0009
Brugia malayi MH1 domain containing protein 0.0015 0.0062 0.0199
Schistosoma mansoni cpg binding protein 0.0031 0.0183 0.0179
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.002 0.0104 0.01
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0104 0.0333
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0353 0.0349
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0409 0.0405
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0004 0.0151
Loa Loa (eye worm) voltage-gated calcium channel 0.002 0.0104 0.0333
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Brugia malayi Smad1 0.0027 0.0153 0.0509
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.3599 0.3596
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0104 0.01
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0022 0.0018
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0027 0.0956
Loa Loa (eye worm) hypothetical protein 0.0242 0.1786 0.5946
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0134 0.183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0206 0.0691
Schistosoma mansoni hypothetical protein 0.0042 0.0266 0.0262
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0027 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0321 0.0317
Mycobacterium ulcerans hypothetical protein 0.0024 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0053 0.0352 0.1161
Brugia malayi hypothetical protein 0.0242 0.1786 0.6104
Schistosoma mansoni hypothetical protein 0.002 0.0104 0.01
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.002 0.0104 0.0342
Toxoplasma gondii hypothetical protein 0.002 0.0104 0.0103
Brugia malayi CHE-14 protein 0.0043 0.0278 0.0939
Loa Loa (eye worm) hypothetical protein 0.0024 0.0134 0.0434
Schistosoma mansoni hypothetical protein 0.0037 0.023 0.0225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0104 0.01
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0005 0.0001
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0041 0.0036
Echinococcus granulosus two pore calcium channel protein 2 0.002 0.0104 0.01
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0442 0.0438
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0013 0.0475
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0012 0.0041 0.1408
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0027 0.0867
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.002 0.0104 0.3863
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0027 0.0867
Brugia malayi TAR-binding protein 0.0065 0.0442 0.15
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Echinococcus granulosus sodium leak channel non selective protein 0.002 0.0104 0.01
Brugia malayi CCR4 0.0008 0.0013 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0415 0.0424
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.002 0.0104 0.3863
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1283 0.97 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0415 1
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0715 0.0711
Echinococcus granulosus TRP transient receptor potential channel 0.002 0.0104 0.01
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0206 0.0202
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.0104 0.01
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.002 0.0104 0.01
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0134 0.0445
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0104 0.01
Schistosoma mansoni hypothetical protein 0.0012 0.0041 0.0036
Onchocerca volvulus 0.0008 0.0013 0.0258
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.002 0.0104 0.01
Echinococcus multilocularis nibrin 0.001 0.0027 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0353 0.0349
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0442 0.1461
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0325 0.1098
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0104 0.01
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0104 0.01
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0013 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily A 0.002 0.0104 0.01
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.002 0.0104 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0415 0.0424
Echinococcus granulosus sodium channel protein 0.002 0.0104 0.01
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.002 0.0104 0.01
Giardia lamblia Replication factor C, subunit 1 0.001 0.0027 0.0538
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0122
Schistosoma mansoni ap endonuclease 0.0041 0.0262 0.0258
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0134 0.0134
Echinococcus multilocularis sodium leak channel non selective protein 0.002 0.0104 0.01
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0262 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0075
Echinococcus multilocularis neuropeptide s receptor 0.048 0.3599 0.3596
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.023 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0956
Loa Loa (eye worm) hypothetical protein 0.0034 0.0206 0.0673
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0013 0.0348
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0104 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0321 0.0317
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0415 0.0411
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0009
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0353 0.0349
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0217 0.1601 0.1597
Schistosoma mansoni transient receptor potential channel 4 0.0401 0.3001 0.2998
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0262 1
Leishmania major hypothetical protein, unknown function 0.002 0.0104 0.2427
Echinococcus granulosus dnaJ subfamily B 0.0412 0.3083 0.308
Brugia malayi MH1 domain containing protein 0.0027 0.0153 0.0509
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0153 0.0149
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0127
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0104 0.01
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0013 0.0127
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0134 0.0134
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0127
Brugia malayi SWIB/MDM2 domain containing protein 0.0012 0.0041 0.0125
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0134 0.183
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0104 0.0103
Schistosoma mansoni voltage-gated cation channel 0.002 0.0104 0.01
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0022 0.0018
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0075
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0104 0.01
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0013 0.0031
Echinococcus granulosus hypothetical protein 0.002 0.0104 0.01
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0206 0.0673
Loa Loa (eye worm) nuclear factor I 0.0015 0.0062 0.0194
Echinococcus multilocularis microtubule associated protein 2 0.0705 0.5309 0.5307
Echinococcus multilocularis potassium large conductance calcium activated 0.002 0.0104 0.01
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.002 0.0104 0.0342
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0027 0.0956
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.002 0.0104 0.01
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0727 0.0723
Echinococcus granulosus ryanodine receptor 44f 0.002 0.0104 0.01
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.002 0.0104 0.01
Schistosoma mansoni hypothetical protein 0.0042 0.0266 0.0262
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0009
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0012 0.0041 0.0121
Loa Loa (eye worm) hypothetical protein 0.0053 0.0353 0.1164
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0262 0.6282
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0013 0.0348
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0442 0.1461
Echinococcus granulosus geminin 0.0533 0.4003 0.4
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.0104 0.01
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0104 0.01
Brugia malayi mothers against decapentaplegic homolog 3 0.0012 0.0041 0.0125
Schistosoma mansoni voltage-gated ion channel 0.002 0.0104 0.01
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0013 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0758 0.2516
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0013 0.0009
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0027 0.0867
Schistosoma mansoni hypothetical protein 0.0331 0.2463 0.2459
Schistosoma mansoni apoferritin-2 0.0009 0.0022 0.0018
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0104 0.01
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0262 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0004 0.0151
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0715 0.0711
Schistosoma mansoni Smad4 0.0012 0.0041 0.0037
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0012 0.0041 0.1046
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0353 1
Brugia malayi cation channel family protein 0.002 0.0104 0.0342
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0027 0.0315
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0013 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0415 0.0424
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0104 0.01
Echinococcus granulosus two pore calcium channel protein 1 0.002 0.0104 0.01
Echinococcus multilocularis mothers against decapentaplegic 6 0.0012 0.0041 0.0037
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.002 0.0104 0.0342
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0104 0.01
Onchocerca volvulus 0.0024 0.0134 0.3728
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0956
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0104 0.01
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0104 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.008 0.0078
Brugia malayi MH1 domain containing protein 0.0015 0.0062 0.0199
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.0104 0.01
Schistosoma mansoni hypothetical protein 0.0533 0.4003 0.4
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0027 0.0023
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0012 0.0041 0.0036
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0027 0.0956
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0013 0.0475
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0104 0.01
Schistosoma mansoni transient receptor potential channel 0.0401 0.3001 0.2998
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0013 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0005 0.0001
Echinococcus granulosus smad 0.0027 0.0153 0.0149
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0333
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0022 0.0018

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis infected in Swiss mice (Mus musculus) assessed as curated mice (Mus musculus) at 96 mg/kg, peroral for 4 days ChEMBL. 20936847
Activity (functional) = 100 % Antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis infected in Swiss mice (Mus musculus) assessed as suppression of parasitaemia at 96 mg/kg, perorally for 4 days relative to control ChEMBL. 20936847
Activity (functional) = 100 % Antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis infected in Swiss mice (Mus musculus) assessed as suppression of parasitaemia at 48 mg/kg, peroral for 4 days relative to control ChEMBL. 20936847

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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