Detailed information for compound 1192005

Basic information

Technical information
  • TDR Targets ID: 1192005
  • Name: 3-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]-6-p iperidin-1-ylsulfonyl-1,3-benzoxazol-2-one
  • MW: 421.51 | Formula: C20H27N3O5S
  • H donors: 0 H acceptors: 4 LogP: 2.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCN(C1)C(=O)Cn1c(=O)oc2c1ccc(c2)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C20H27N3O5S/c1-15-6-5-9-21(13-15)19(24)14-23-17-8-7-16(12-18(17)28-20(23)25)29(26,27)22-10-3-2-4-11-22/h7-8,12,15H,2-6,9-11,13-14H2,1H3
  • InChiKey: WFZHUYBVNITLMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(3-methyl-1-piperidyl)-2-oxo-ethyl]-6-(1-piperidylsulfonyl)-1,3-benzoxazol-2-one
  • 3-[2-(3-methyl-1-piperidinyl)-2-oxoethyl]-6-(1-piperidylsulfonyl)-1,3-benzoxazol-2-one
  • 3-[2-keto-2-(3-methyl-1-piperidyl)ethyl]-6-piperidinosulfonyl-1,3-benzoxazol-2-one
  • 3-[2-(3-methylpiperidin-1-yl)-2-oxo-ethyl]-6-piperidin-1-ylsulfonyl-1,3-benzoxazol-2-one
  • C732-0055
  • NCGC00112615-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0092 0.0253
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.022 0.122 0.1336
Echinococcus multilocularis protein patched 0.0041 0.007 0.007
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0329 0.2174
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0087 0.0364 0.14
Loa Loa (eye worm) hypothetical protein 0.0047 0.0108 0.0118
Toxoplasma gondii PAN/Apple domain-containing protein 0.0052 0.0141 0.0189
Brugia malayi hypothetical protein 0.0741 0.4565 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0286 0.0313
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0468 0.2812 0.308
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Echinococcus granulosus fibropellin Ia 0.0468 0.2812 0.3754
Brugia malayi Fibulin-1 precursor 0.1198 0.7492 0.8205
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.1198 0.7492 0.8205
Brugia malayi prolyl oligopeptidase family protein 0.0267 0.1524 0.1669
Echinococcus multilocularis geminin 0.0158 0.0821 0.0821
Brugia malayi Cadherin domain containing protein 0.0468 0.2812 0.308
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Echinococcus multilocularis protein jagged 1 0.0468 0.2812 0.2812
Brugia malayi Protein kinase domain containing protein 0.0086 0.0362 0.0397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Schistosoma mansoni carbonic anhydrase-related 0.022 0.122 0.1336
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Schistosoma mansoni hypothetical protein 0.0468 0.2812 0.308
Echinococcus multilocularis protein jagged 1 0.0468 0.2812 0.2812
Toxoplasma gondii hypothetical protein 0.0045 0.0096 0.0128
Onchocerca volvulus 0.0052 0.0141 0.0155
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0087 0.0364 0.1115
Echinococcus multilocularis snurportin 1 0.0372 0.2193 0.2193
Echinococcus granulosus delta-like protein 1 0.0468 0.2812 0.3754
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.0362 0.1168
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1147 0.1256
Loa Loa (eye worm) hypothetical protein 0.0074 0.0286 0.0313
Loa Loa (eye worm) hypothetical protein 0.0106 0.0486 0.0532
Schistosoma mansoni laminin gamma-3 chain 0.0468 0.2812 0.308
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0419 0.0419
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1826 0.7479
Giardia lamblia High cysteine protein 0.0468 0.2812 1
Echinococcus multilocularis laminin 0.1198 0.7492 0.7492
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0263 0.0351
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0682 0.0682
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1826 0.7479
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0034
Leishmania major carbonic anhydrase-like protein 0.0406 0.241 1
Schistosoma mansoni notch 0.0468 0.2812 0.308
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0032 0.0211
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0141 0.0155
Trypanosoma cruzi oligopeptidase b 0.0087 0.0364 0.1177
Onchocerca volvulus 0.0052 0.0141 0.0155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0162 0.0178
Onchocerca volvulus 0.0468 0.2812 0.308
Echinococcus multilocularis microtubule associated protein 2 0.0643 0.3932 0.3932
Loa Loa (eye worm) carbonic anhydrase 3 0.0406 0.241 0.2639
Schistosoma mansoni notch 0.0468 0.2812 0.308
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0286 0.0684
Loa Loa (eye worm) hypothetical protein 0.009 0.0383 0.0419
Loa Loa (eye worm) hypothetical protein 0.0047 0.0108 0.0118
Onchocerca volvulus 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0048 0.0115 0.0126
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0142
Brugia malayi EGF-like domain containing protein 0.0468 0.2812 0.308
Onchocerca volvulus Slit protein homolog 0.0468 0.2812 0.308
Schistosoma mansoni hypothetical protein 0.0266 0.1514 0.1658
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0286 0.0655
Toxoplasma gondii hypothetical protein 0.022 0.122 0.1628
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Echinococcus multilocularis fibropellin Ia 0.0468 0.2812 0.2812
Brugia malayi EGF-like domain containing protein 0.0468 0.2812 0.308
Brugia malayi RNA, U transporter 1 0.0099 0.0443 0.0485
Onchocerca volvulus 0.0346 0.2027 0.222
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.0362 0.4446
Schistosoma mansoni survival motor neuron protein 0.0151 0.0778 0.0852
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0383 0.0383
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0329 0.5
Loa Loa (eye worm) PAN domain-containing protein 0.0052 0.0141 0.0155
Brugia malayi Importin beta-1 subunit 0.0035 0.0031 0.0034
Brugia malayi Probable ClpP-like protease 0.0081 0.0329 0.0361
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Schistosoma mansoni cell polarity protein 0.0468 0.2812 0.308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Echinococcus multilocularis fat cadherin tumor suppressor 0.0468 0.2812 0.2812
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0329 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0263 0.0288
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0286 0.1707
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0406 0.241 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0108 0.0226
Echinococcus multilocularis neurogenic locus protein delta 0.0468 0.2812 0.2812
Echinococcus granulosus importin subunit beta 1 0.0035 0.0031 0.0042
Schistosoma mansoni hypothetical protein 0.0468 0.2812 0.308
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.015 0.0334
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0032 0.0004
Echinococcus granulosus GPCR family 2 0.0031 0.0007 0.001
Brugia malayi CHE-14 protein 0.0041 0.007 0.0077
Toxoplasma gondii microneme protein MIC17A 0.0052 0.0141 0.0189
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0203 0.1109 0.4387
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0096 0.002
Loa Loa (eye worm) bone morphogenetic protein 1b 0.1198 0.7492 0.8205
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0346 0.2027 0.2705
Onchocerca volvulus 0.1107 0.6912 0.757
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0346 0.2027 0.222
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Toxoplasma gondii microneme protein MIC17B 0.0052 0.0141 0.0189
Brugia malayi EGF-like domain containing protein 0.0468 0.2812 0.308
Schistosoma mansoni hypothetical protein 0.0372 0.2193 0.2402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0178
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0045 0.0096 0.0204
Schistosoma mansoni hypothetical protein 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0007 0.0008
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.1198 0.7492 0.8205
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0617 0.0676
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0763 0.3075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0217
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0086 0.0362 0.1391
Loa Loa (eye worm) hypothetical protein 0.0047 0.0108 0.0118
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0763 0.2895
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0263 0.0263
Onchocerca volvulus 0.0346 0.2027 0.222
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1332 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0763 0.2845
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0077
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0286 0.0313
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0266 0.1514 1
Echinococcus multilocularis neurogenic locus notch protein 0.0468 0.2812 0.2812
Leishmania major hypothetical protein, conserved 0.0266 0.1514 0.6108
Echinococcus multilocularis expressed conserved protein 0.009 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0412 0.2452 0.3273
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0313 0.0343
Schistosoma mansoni septate junction protein 0.0468 0.2812 0.308
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0346 0.2027 0.2027
Loa Loa (eye worm) hypothetical protein 0.0346 0.2027 0.222
Loa Loa (eye worm) hypothetical protein 0.0086 0.0359 0.0394
Onchocerca volvulus 0.0052 0.0141 0.0155
Entamoeba histolytica hypothetical protein 0.0071 0.0263 0.2785
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0346 0.2027 0.222
Toxoplasma gondii microneme protein, putative 0.0052 0.0141 0.0189
Brugia malayi Trypsin-like protease protein 5 0.0346 0.2027 0.222
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0203 0.1109 0.1214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0217
Brugia malayi beta-lactamase family protein 0.0074 0.0286 0.0313
Onchocerca volvulus 0.0052 0.0141 0.0155
Schistosoma mansoni carbonic anhydrase-related 0.022 0.122 0.1336
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0329 0.0361
Loa Loa (eye worm) hypothetical protein 0.0074 0.0286 0.0313
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Mycobacterium ulcerans lipase LipD 0.0074 0.0286 0.0655
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Echinococcus granulosus expressed conserved protein 0.009 0.0382 0.051
Brugia malayi Calcium binding EGF domain containing protein 0.0468 0.2812 0.308
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0267 0.1524 0.1669
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0162
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0173 0.0916 0.1003
Loa Loa (eye worm) hypothetical protein 0.0346 0.2027 0.222
Echinococcus granulosus prolyl endopeptidase 0.0173 0.0916 0.1223
Onchocerca volvulus 0.0151 0.0778 0.0852
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0203 0.1109 0.1109
Echinococcus granulosus tumor protein p63 0.0327 0.1907 0.2545
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0438 0.048
Loa Loa (eye worm) hypothetical protein 0.0346 0.2027 0.222
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0108 0.0195
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0052 0.0141 0.0189
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0115 0.0126
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0617 0.0824
Echinococcus multilocularis GPCR, family 2 0.0031 0.0007 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2193 0.2402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0286 0.1707
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0406 0.241 0.2639
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0239 0.1338 0.1466
Toxoplasma gondii PAN domain-containing protein 0.0052 0.0141 0.0189
Loa Loa (eye worm) hypothetical protein 0.0173 0.0916 0.1003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0329 0.0582
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0108 0.0195
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0639 0.391 1
Schistosoma mansoni hypothetical protein 0.0067 0.0239 0.0262
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Onchocerca volvulus 0.0346 0.2027 0.222
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0286 0.1707
Echinococcus granulosus notch 0.0468 0.2812 0.3754
Brugia malayi beta-lactamase family protein 0.0074 0.0286 0.0313
Echinococcus granulosus neurogenic locus notch protein 4 0.0468 0.2812 0.3754
Echinococcus granulosus carbonic anhydrase II 0.0406 0.241 0.3217
Loa Loa (eye worm) hypothetical protein 0.0052 0.0141 0.0155
Echinococcus multilocularis prolyl endopeptidase 0.0173 0.0916 0.0916
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.0096 0.0105
Brugia malayi TAR-binding protein 0.0064 0.0216 0.0236
Trichomonas vaginalis esterase, putative 0.0074 0.0286 0.1707
Schistosoma mansoni hypothetical protein 0.0039 0.0061 0.0067
Brugia malayi Muscle positioning protein 4 0.0468 0.2812 0.308
Echinococcus granulosus acylamino acid releasing enzyme 0.0045 0.0096 0.0128
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0203 0.1109 0.4347
Brugia malayi hypothetical protein 0.0097 0.0431 0.0472
Loa Loa (eye worm) hypothetical protein 0.0074 0.0286 0.0313
Toxoplasma gondii PAN domain-containing protein 0.0052 0.0141 0.0189
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0617 0.0824
Brugia malayi EGF-like domain containing protein 0.0468 0.2812 0.308
Onchocerca volvulus 0.0048 0.0115 0.0126
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Echinococcus granulosus neurogenic locus notch protein 0.0468 0.2812 0.3754
Onchocerca volvulus Arrow homolog 0.1198 0.7492 0.8205
Loa Loa (eye worm) hypothetical protein 0.0216 0.1194 0.1308
Echinococcus granulosus transmembrane protease serine 3 0.0346 0.2027 0.2705
Loa Loa (eye worm) hypothetical protein 0.0346 0.2027 0.222
Echinococcus multilocularis transmembrane protease serine 3 0.0346 0.2027 0.2027
Giardia lamblia Fructose-bisphosphate aldolase 0.0138 0.0695 0.2204
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.0383 0.0419
Loa Loa (eye worm) hypothetical protein 0.022 0.122 0.1336
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0286 0.0838
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0429 0.047
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0216 0.0236
Brugia malayi Calcium binding EGF domain containing protein 0.0468 0.2812 0.308
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0329 0.0439
Brugia malayi Delta serrate ligand family protein 0.0468 0.2812 0.308
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0286 0.0313
Schistosoma mansoni carbonic anhydrase 0.022 0.122 0.1336
Echinococcus multilocularis dual specificity 0.0086 0.0362 0.0362
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0329 0.0767
Loa Loa (eye worm) hypothetical protein 0.0097 0.0431 0.0472
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.015 0.02
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0108 0.0195
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.1198 0.7492 0.8205
Schistosoma mansoni carbonic anhydrase-related 0.022 0.122 0.1336
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0617 0.151
Brugia malayi Cadherin domain containing protein 0.0468 0.2812 0.308
Echinococcus granulosus protein jagged 2 0.0468 0.2812 0.3754
Onchocerca volvulus 0.0468 0.2812 0.308
Echinococcus granulosus geminin 0.0158 0.0821 0.1095
Onchocerca volvulus Putative cubilin 0.0468 0.2812 0.308
Brugia malayi EGF-like domain containing protein 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0074 0.0286 0.0313
Schistosoma mansoni hypothetical protein 0.0039 0.0061 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Schistosoma mansoni hypothetical protein 0.0039 0.0061 0.0067
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0286 0.0684
Loa Loa (eye worm) hypothetical protein 0.1386 0.87 0.9529
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0086 0.0362 0.1106
Loa Loa (eye worm) hypothetical protein 0.0045 0.0096 0.0105
Schistosoma mansoni slit 0.0468 0.2812 0.308
Onchocerca volvulus 0.0074 0.0286 0.0313
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Echinococcus granulosus carbonic anhydrase 0.022 0.122 0.1628
Loa Loa (eye worm) PAN domain-containing protein 0.0052 0.0141 0.0155
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0412 0.2452 0.2686
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0267 0.1524 0.2034
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1453 0.913 1
Echinococcus granulosus slit 2 protein 0.0468 0.2812 0.3754
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0267 0.1524 0.1524
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0108 0.0194
Onchocerca volvulus 0.0047 0.0108 0.0118
Echinococcus multilocularis Mastin 0.0346 0.2027 0.2027
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0151 0.0778 0.0852
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0138 0.0695 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0329 0.0767
Loa Loa (eye worm) hypothetical protein 0.0095 0.0419 0.0459
Trypanosoma brucei carbonic anhydrase-like protein 0.0406 0.241 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0383 0.0511
Echinococcus granulosus Mastin 0.0346 0.2027 0.2705
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0008
Brugia malayi notch-like transmembrane receptor 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0098 0.0438 0.048
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.022 0.122 0.1336
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0639 0.391 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0346 0.2027 0.222
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.0096 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0035
Echinococcus multilocularis fibrillin 1 0.1198 0.7492 0.7492
Toxoplasma gondii PAN domain-containing protein 0.0052 0.0141 0.0189
Loa Loa (eye worm) hypothetical protein 0.0052 0.0141 0.0155
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Onchocerca volvulus 0.0346 0.2027 0.222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1453 0.913 1
Trypanosoma brucei oligopeptidase b 0.0087 0.0364 0.14
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0007 0.001
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0216 0.0236
Echinococcus multilocularis glycoprotein Antigen 5 0.0346 0.2027 0.2027
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0108 0.0118
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0286 0.0381
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0045 0.0096 0.0204
Mycobacterium tuberculosis Conserved protein 0.0074 0.0286 0.0684
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0346 0.2027 0.222
Onchocerca volvulus 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Mycobacterium tuberculosis Probable peptidase 0.0087 0.0364 0.0886
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Brugia malayi Trypsin family protein 0.0346 0.2027 0.222
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0406 0.241 0.2639
Brugia malayi Calcium binding EGF domain containing protein 0.1198 0.7492 0.8205
Echinococcus granulosus Protein patched homolog 1 0.0041 0.007 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0108 0.0226
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0087 0.0364 0.1177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0162
Echinococcus granulosus tar DNA binding protein 0.0064 0.0216 0.0288
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0108 0.0194
Entamoeba histolytica hypothetical protein 0.0086 0.0362 0.4446
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0419 0.056
Echinococcus multilocularis carbonic anhydrase II 0.0406 0.241 0.241
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0216 0.0236
Echinococcus granulosus Tolloid protein 1 0.1198 0.7492 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0313 0.0418
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0045 0.0096 0.0105
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0639 0.391 1
Toxoplasma gondii ABC1 family protein 0.0074 0.0286 0.0381
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0045 0.0096 0.0128
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0108 0.0195
Loa Loa (eye worm) hypothetical protein 0.0086 0.0359 0.0394
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.022 0.122 0.1336
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0617 0.2214
Onchocerca volvulus 0.0346 0.2027 0.222
Schistosoma mansoni hypothetical protein 0.0468 0.2812 0.308
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.0362 0.1168
Loa Loa (eye worm) hypothetical protein 0.0052 0.0141 0.0155
Onchocerca volvulus 0.0052 0.0141 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0096 0.002
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0087 0.0364 0.0886
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0286 0.0655
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0617 0.1537
Trypanosoma brucei prolyl oligopeptidase, putative 0.0087 0.0364 0.14
Schistosoma mansoni egf-like domain protein 0.1198 0.7492 0.8205
Echinococcus multilocularis acylamino acid releasing enzyme 0.0045 0.0096 0.0096
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.009 0.0383 0.0511
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.007 0.0094
Loa Loa (eye worm) PAN domain-containing protein 0.0052 0.0141 0.0155
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0216 0.0236
Loa Loa (eye worm) Notch2 0.0468 0.2812 0.308
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0346 0.2027 0.2027
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0008
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Echinococcus multilocularis tissue type plasminogen activator 0.0266 0.1514 0.1514
Brugia malayi GCC2 and GCC3 family protein 0.0468 0.2812 0.308
Echinococcus granulosus tissue type plasminogen activator 0.0266 0.1514 0.2021
Schistosoma mansoni importin beta-1 0.0035 0.0031 0.0034
Mycobacterium ulcerans hypothetical protein 0.0074 0.0286 0.0655
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0173 0.0916 0.1003
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0216 0.0236
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0346 0.2027 0.222
Loa Loa (eye worm) hypothetical protein 0.0052 0.0141 0.0155
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0438 0.048
Onchocerca volvulus Neurogenic locus notch homolog 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.1453 0.913 1
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0032 0.0031
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0203 0.1109 0.4529
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Onchocerca volvulus 0.0074 0.0286 0.0313
Loa Loa (eye worm) beta-lactamase 0.0074 0.0286 0.0313
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.022 0.122 0.1336
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0045 0.0096 0.0105
Toxoplasma gondii PAN domain-containing protein 0.0603 0.3679 0.4911
Onchocerca volvulus 0.1453 0.913 1
Echinococcus granulosus protein jagged 2 0.0468 0.2812 0.3754
Mycobacterium tuberculosis Conserved protein 0.0074 0.0286 0.0684
Toxoplasma gondii prolyl endopeptidase 0.0173 0.0916 0.1223
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0406 0.241 0.2639
Loa Loa (eye worm) hypothetical protein 0.1198 0.7492 0.8205
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0286 0.0838
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0286 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0178
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.2861 0.7304
Echinococcus granulosus neural cadherin 0.0468 0.2812 0.3754
Loa Loa (eye worm) hypothetical protein 0.1198 0.7492 0.8205
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0286 0.0684
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0154 0.0268
Schistosoma mansoni notch 0.0468 0.2812 0.308
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Brugia malayi hypothetical protein 0.0346 0.2027 0.222
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Loa Loa (eye worm) PAN domain-containing protein 0.0052 0.0141 0.0155
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0468 0.2812 0.308
Trypanosoma cruzi oligopeptidase b 0.0087 0.0364 0.1177
Loa Loa (eye worm) trypsin family protein 0.0346 0.2027 0.222
Toxoplasma gondii PAN domain-containing protein 0.0052 0.0141 0.0189
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0045 0.0096 0.0273
Toxoplasma gondii microneme protein MIC17C 0.0052 0.0141 0.0189
Treponema pallidum fructose-bisphosphate aldolase 0.0138 0.0695 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0329 0.0439
Echinococcus multilocularis carbonic anhydrase 0.022 0.122 0.122
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Toxoplasma gondii PAN domain-containing protein 0.0603 0.3679 0.4911
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0008
Loa Loa (eye worm) prolyl oligopeptidase 0.0267 0.1524 0.1669
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0286 0.1707
Loa Loa (eye worm) hypothetical protein 0.1198 0.7492 0.8205
Echinococcus multilocularis carbonic anhydrase 0.022 0.122 0.122
Brugia malayi prolyl oligopeptidase family protein 0.0173 0.0916 0.1003
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0286 0.1888
Echinococcus multilocularis enteropeptidase 0.0346 0.2027 0.2027
Onchocerca volvulus 0.0052 0.0141 0.0155
Schistosoma mansoni notch 0.0468 0.2812 0.308
Brugia malayi beta-lactamase 0.0074 0.0286 0.0313
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0216 0.0216
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0203 0.1109 0.4387
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0203 0.1109 0.4529
Brugia malayi Trypsin family protein 0.1453 0.913 1
Schistosoma mansoni hypothetical protein 0.0158 0.0821 0.0899
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0329 0.0439
Toxoplasma gondii microneme protein MIC4 0.0052 0.0141 0.0189
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0406 0.241 0.2639
Toxoplasma gondii hypothetical protein 0.0052 0.0141 0.0189
Brugia malayi Protein kinase domain containing protein 0.0266 0.1514 0.1658
Mycobacterium ulcerans hypothetical protein 0.0047 0.0108 0.0195
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0087 0.0364 0.0675
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Onchocerca volvulus 0.0074 0.0286 0.0313
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0108 0.0118
Toxoplasma gondii hypothetical protein 0.0052 0.0141 0.0189
Toxoplasma gondii hypothetical protein 0.0051 0.0133 0.0178
Onchocerca volvulus 0.0052 0.0141 0.0155
Entamoeba histolytica protein kinase, putative 0.0086 0.0362 0.4446
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0286 0.0684
Echinococcus granulosus microtubule associated protein 2 0.0643 0.3932 0.5249
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0007 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Onchocerca volvulus 0.0052 0.0141 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0286 0.107
Echinococcus multilocularis protein dispatched 1 0.0047 0.0107 0.0107
Mycobacterium ulcerans hypothetical protein 0.0166 0.0871 0.2163
Onchocerca volvulus 0.0052 0.0141 0.0155
Loa Loa (eye worm) hypothetical protein 0.0081 0.0329 0.0361
Onchocerca volvulus Prolyl endopeptidase homolog 0.0173 0.0916 0.1003
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0346 0.2027 0.2705
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.015 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Brugia malayi RNA binding protein 0.0064 0.0216 0.0236
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0007 0.0007
Brugia malayi prolyl oligopeptidase family protein 0.0203 0.1109 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0096 0.0204
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.015 0.015
Echinococcus granulosus carbonic anhydrase 0.022 0.122 0.1628
Loa Loa (eye worm) hypothetical protein 0.0052 0.0141 0.0155
Loa Loa (eye worm) hypothetical protein 0.1453 0.913 1
Schistosoma mansoni hypothetical protein 0.0039 0.0061 0.0067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.0871 0.2188
Trypanosoma cruzi hypothetical protein, conserved 0.0266 0.1514 0.6135
Echinococcus multilocularis survival motor neuron protein 1 0.0741 0.4565 0.4565
Schistosoma mansoni hypothetical protein 0.0071 0.0263 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0216 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0362 0.0397
Loa Loa (eye worm) TK/ROR protein kinase 0.0266 0.1514 0.1658
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0267 0.1524 0.1669
Brugia malayi EGF-like domain containing protein 0.0468 0.2812 0.308
Brugia malayi EGF-like domain containing protein 0.0468 0.2812 0.308
Loa Loa (eye worm) notch protein 0.0468 0.2812 0.308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0108 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0216 0.0236
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.009 0.0383 0.1056
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0286 0.0684
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0346 0.2027 0.222
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0286 0.0684
Schistosoma mansoni hypothetical protein 0.0468 0.2812 0.308
Echinococcus multilocularis Tolloid protein 1 0.1198 0.7492 0.7492
Loa Loa (eye worm) RNA binding protein 0.0064 0.0216 0.0236
Brugia malayi Trypsin family protein 0.0346 0.2027 0.222
Toxoplasma gondii calcium binding egf domain-containing protein 0.1198 0.7492 1
Loa Loa (eye worm) hypothetical protein 0.022 0.122 0.1336
Loa Loa (eye worm) prolyl oligopeptidase 0.0045 0.0096 0.0105
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0419 0.0459
Toxoplasma gondii EGF family domain-containing protein 0.0468 0.2812 0.3754
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.1826 0.7543
Echinococcus multilocularis protein jagged 2 0.0468 0.2812 0.2812
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0313 0.0313
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0313 0.0343
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0329 0.2009
Schistosoma mansoni notch 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0067 0.0239 0.0262
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0286 0.0313
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0406 0.241 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0346 0.2027 0.222
Echinococcus granulosus survival motor neuron protein 1 0.0741 0.4565 0.6093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0035
Mycobacterium leprae Probable lipase LipE 0.0074 0.0286 0.0468
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0617 0.151
Echinococcus multilocularis neural cadherin 0.0468 0.2812 0.2812
Plasmodium falciparum carbonic anhydrase 0.022 0.122 0.8016
Schistosoma mansoni cercarial elastase (S01 family) 0.0346 0.2027 0.222
Toxoplasma gondii subtilisin SUB12 0.0052 0.0141 0.0189
Schistosoma mansoni hypothetical protein 0.0346 0.2027 0.222
Loa Loa (eye worm) hypothetical protein 0.1198 0.7492 0.8205
Schistosoma mansoni hypothetical protein 0.022 0.122 0.1336
Echinococcus multilocularis slit 2 protein 0.0468 0.2812 0.2812
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0142 0.0719 0.096
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0682 0.091
Brugia malayi Trypsin family protein 0.0346 0.2027 0.222
Echinococcus granulosus enteropeptidase 0.0346 0.2027 0.2705
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0087 0.0364 0.1177
Mycobacterium ulcerans hypothetical protein 0.0346 0.2027 0.5144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0108 0.0195
Schistosoma mansoni patched 1 0.0041 0.007 0.0077
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.022 0.122 0.1336
Entamoeba histolytica hypothetical protein 0.0071 0.0263 0.2785
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0239 0.0262
Schistosoma mansoni hypothetical protein 0.0158 0.0821 0.0899
Loa Loa (eye worm) PAN domain-containing protein 0.0052 0.0141 0.0155
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0086 0.0362 0.0397
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0412 0.2452 0.2452
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0108 0.0195
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0227 0.1262 0.1382
Echinococcus multilocularis notch 0.0468 0.2812 0.2812
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0108 0.0118
Entamoeba histolytica hypothetical protein 0.0071 0.0263 0.2785
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.007 0.0077
Onchocerca volvulus 0.0266 0.1514 0.1658
Entamoeba histolytica hypothetical protein 0.0071 0.0263 0.2785
Toxoplasma gondii kringle domain-containing protein 0.0266 0.1514 0.2021
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0216 0.0236
Schistosoma mansoni hypothetical protein 0.0468 0.2812 0.308
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.015 0.0334
Schistosoma mansoni microtubule-associated protein tau 0.0643 0.3932 0.4307
Loa Loa (eye worm) hypothetical protein 0.0741 0.4565 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0138 0.0695 1
Echinococcus multilocularis carbonic anhydrase 0.022 0.122 0.122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0178
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0286 0.0684
Echinococcus multilocularis neurogenic locus notch protein 0.0468 0.2812 0.2812
Entamoeba histolytica protein kinase, putative 0.0086 0.0362 0.4446
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0438 0.048
Onchocerca volvulus 0.0052 0.0141 0.0155
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0329 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.1198 0.7492 1
Brugia malayi PAN domain containing protein 0.0052 0.0141 0.0155
Onchocerca volvulus 0.0052 0.0141 0.0155
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0406 0.241 0.2639
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0087 0.0364 0.0857
Brugia malayi Kringle domain containing protein 0.0266 0.1514 0.1658
Brugia malayi nuclear hormone receptor 0.0227 0.1262 0.1382
Echinococcus granulosus glycoprotein Antigen 5 0.0346 0.2027 0.2705
Plasmodium vivax importin-beta 2, putative 0.0035 0.0031 0.0207
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0286 0.1707
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0617 0.0676
Schistosoma mansoni notch 0.0468 0.2812 0.308
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0468 0.2812 0.308
Echinococcus granulosus protein jagged 1 0.0468 0.2812 0.3754
Brugia malayi hypothetical protein 0.0071 0.0263 0.0288
Schistosoma mansoni hypothetical protein 0.0151 0.0778 0.0852
Brugia malayi Calcium binding EGF domain containing protein 0.0468 0.2812 0.308
Echinococcus granulosus laminin 0.1198 0.7492 1
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.1826 0.7462
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0383 0.0511
Echinococcus granulosus snurportin 1 0.0372 0.2193 0.2927
Echinococcus multilocularis neurogenic locus notch protein 4 0.0468 0.2812 0.2812
Echinococcus granulosus protein jagged 1 0.0468 0.2812 0.3754
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0286 0.0286
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0346 0.2027 0.222
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0096 0.0635
Echinococcus granulosus carbonic anhydrase 0.022 0.122 0.1628
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0128 0.0628 0.1564
Loa Loa (eye worm) hypothetical protein 0.1198 0.7492 0.8205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.0695 0.4949
Trypanosoma cruzi prolyl endopeptidase 0.0173 0.0916 0.3557
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0419 0.5401
Schistosoma mansoni hypothetical protein 0.0346 0.2027 0.222
Brugia malayi Pre-SET motif family protein 0.0209 0.1147 0.1256
Echinococcus multilocularis neurogenic locus protein delta 0.0468 0.2812 0.2812
Loa Loa (eye worm) hypothetical protein 0.0266 0.1514 0.1658
Trypanosoma brucei prolyl endopeptidase 0.0173 0.0916 0.372
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.022 0.122 0.1336
Echinococcus granulosus neurogenic locus protein delta 0.0468 0.2812 0.3754
Echinococcus granulosus dual specificity 0.0086 0.0362 0.0484
Onchocerca volvulus 0.0238 0.1332 0.1459
Mycobacterium ulcerans beta-lactamase 0.0074 0.0286 0.0655
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.1198 0.7492 0.8205
Onchocerca volvulus 0.0468 0.2812 0.308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0008
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0173 0.0916 0.3512
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0162 0.0178
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0108 0.0194
Echinococcus granulosus neurogenic locus notch protein 0.0468 0.2812 0.3754
Echinococcus granulosus Dipeptidyl peptidase 9 0.0203 0.1109 0.148
Leishmania major hypothetical protein, conserved 0.0074 0.0286 0.0773
Leishmania major oligopeptidase b 0.0087 0.0364 0.1115
Loa Loa (eye worm) hypothetical protein 0.0468 0.2812 0.308
Plasmodium falciparum cysteine repeat modular protein 1 0.0266 0.1514 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0286 0.0313
Loa Loa (eye worm) hypothetical protein 0.0052 0.0141 0.0155
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0617 0.151
Mycobacterium tuberculosis Conserved protein 0.0074 0.0286 0.0684
Plasmodium falciparum peptidase, putative 0.0045 0.0096 0.0437
Echinococcus multilocularis tumor protein p63 0.0327 0.1907 0.1907
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0286 0.0468

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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