Detailed information for compound 1217377

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 580.708 | Formula: C33H42F2N4O3
  • H donors: 2 H acceptors: 3 LogP: 4.22 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCN(C(=O)NCc1ccc(cc1F)F)C1CCN(CC1)C[C@H]1CN(C[C@]1(O)c1ccccc1)C(=O)C1CCCC1
  • InChi: 1S/C33H42F2N4O3/c1-2-16-39(32(41)36-20-25-12-13-28(34)19-30(25)35)29-14-17-37(18-15-29)21-27-22-38(31(40)24-8-6-7-9-24)23-33(27,42)26-10-4-3-5-11-26/h2-5,10-13,19,24,27,29,42H,1,6-9,14-18,20-23H2,(H,36,41)/t27-,33-/m0/s1
  • InChiKey: NJPKXRZXJBFFPB-CMVGPNDKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0079 0.0354 0.1452
Loa Loa (eye worm) glutamate receptor 1 0.0071 0.0305 0.048
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0115 0.0581 0.2384
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0069 0.0096
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0196 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0115 0.0581 0.2384
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0051 0.021
Schistosoma mansoni hypothetical protein 0.0063 0.0254 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Echinococcus multilocularis dna polymerase eta 0.0039 0.0101 0.0101
Echinococcus multilocularis protoporphyrinogen oxidase 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.0578 0.1274
Giardia lamblia Cysteine protease 0.0115 0.0581 0.2458
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.1004 0.1584
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0101 0.016
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0101 0.016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0092 0.0376
Mycobacterium tuberculosis Conserved protein 0.0115 0.0578 0.1274
Schistosoma mansoni cathepsin s 0.0068 0.0281 0.0389
Echinococcus multilocularis tumor protein p63 0.0676 0.4101 0.4101
Echinococcus multilocularis histone deacetylase 7 0.0041 0.0117 0.0117
Leishmania major oligopeptidase b 0.0053 0.019 0.0778
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0054 0.0198 0.0313
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0162 0.0875 0.1212
Echinococcus granulosus glutamate receptor 1 0.0045 0.0138 0.0191
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1004 0.4122
Brugia malayi Hemopexin family protein 0.0063 0.0254 0.0401
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0053 0.019 0.1148
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0254 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0578 0.0912
Plasmodium falciparum plasmepsin IV 0.0034 0.0069 0.0283
Brugia malayi Matrixin family protein 0.0045 0.0137 0.0217
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0079 0.0354 0.0354
Brugia malayi beta-lactamase 0.0115 0.0578 0.0912
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0079 0.0354 0.1452
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0028 0.0036 0.005
Echinococcus granulosus chromobox protein 1 0.0079 0.0354 0.049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Giardia lamblia Cathepsin B precursor 0.0115 0.0581 0.2458
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0101 0.0101
Leishmania major UDP-galactopyranose mutase 0.0028 0.0036 0.0148
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.019 0.0778
Onchocerca volvulus 0.0115 0.0581 0.2349
Mycobacterium ulcerans hydrolase 0.0054 0.0198 0.1204
Plasmodium falciparum serine repeat antigen 5 0.0115 0.0581 0.2384
Entamoeba histolytica cysteine protease, putative 0.0115 0.0581 0.2384
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.0578 0.0912
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0229 0.1402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0054 0.0196 0.0309
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0196 0.0271
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0069 0.0283
Onchocerca volvulus 0.0115 0.0578 0.2338
Giardia lamblia Cysteine protease 0.0115 0.0581 0.2458
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0115 0.0581 0.2458
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0015 0.006
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0079 0.0354 0.049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0101 0.016
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0354 0.1452
Plasmodium falciparum histone deacetylase 2 0.0041 0.0117 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Plasmodium falciparum plasmepsin IX 0.0034 0.0069 0.0283
Brugia malayi Papain family cysteine protease containing protein 0.0115 0.0581 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.1004 0.4122
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.019 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Loa Loa (eye worm) hypothetical protein 0.0054 0.0198 0.0313
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0069 0.0283
Entamoeba histolytica cysteine proteinase 2 0.0183 0.1004 0.4122
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0034 0.0069 0.0283
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0354 0.1452
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.0578 0.1274
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.0578 0.08
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0079 0.0354 0.049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Echinococcus multilocularis glutamate receptor 2 0.0071 0.0305 0.0305
Toxoplasma gondii cathepsin B 0.0399 0.2363 0.9697
Brugia malayi Histone deacetylase family protein 0.0041 0.0117 0.0184
Entamoeba histolytica cysteine proteinase 1, putative 0.0183 0.1004 0.4122
Plasmodium falciparum importin beta, putative 0.0031 0.0051 0.021
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0079 0.0354 0.049
Schistosoma mansoni ap endonuclease 0.0037 0.0092 0.0127
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0069 0.0283
Schistosoma mansoni pyruvate kinase 0.0033 0.0066 0.0092
Onchocerca volvulus 0.0079 0.0354 0.1412
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0066 0.0227
Echinococcus multilocularis chromobox protein 2 0.1174 0.7224 0.7224
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032 0.0056 0.0056
Plasmodium vivax serine-repeat antigen (SERA) 0.0115 0.0581 0.2384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Loa Loa (eye worm) histone deacetylase 0.0041 0.0117 0.0184
Leishmania major pyruvate kinase 0.0033 0.0066 0.0271
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0066 0.0123
Onchocerca volvulus Cathepsin L homolog 0.0411 0.2437 1
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Brugia malayi Cathepsin L-like precursor 0.0411 0.2437 0.3842
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0229 0.0941
Plasmodium vivax unspecified product 0.0115 0.0581 0.2384
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0578 0.08
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0045 0.0137 0.019
Trichomonas vaginalis hypothetical protein 0.0079 0.0354 0.1452
Plasmodium vivax histone deacetylase, putative 0.0041 0.0117 0.0479
Echinococcus multilocularis pyruvate kinase 0.0033 0.0066 0.0066
Schistosoma mansoni glutamate receptor NMDA 0.0027 0.0024 0.0033
Brugia malayi mbt repeat family protein 0.0047 0.0155 0.0244
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0068 0.0281 0.0443
Brugia malayi mbt repeat family protein 0.0047 0.0155 0.0244
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0119 0.0605 0.1335
Schistosoma mansoni hypothetical protein 0.0329 0.1925 0.2664
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0578 0.2373
Echinococcus granulosus cysteine protease 0.0183 0.1004 0.1391
Echinococcus granulosus snurportin 1 0.0329 0.1925 0.2664
Brugia malayi Glutamate receptor 2 precursor 0.0071 0.0305 0.048
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0115 0.0581 0.2384
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0101 0.0202
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0115 0.0581 0.2384
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0229 0.0941
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0066 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.2437 0.3842
Echinococcus multilocularis glutamate receptor 2 0.0066 0.0274 0.0274
Brugia malayi cathepsin L precursor 0.0115 0.0581 0.0916
Loa Loa (eye worm) MBCTL1 0.0054 0.0196 0.0309
Loa Loa (eye worm) hypothetical protein 0.0099 0.0479 0.0754
Mycobacterium ulcerans monoamine oxidase 0.0028 0.0036 0.016
Leishmania major hypothetical protein, conserved 0.0115 0.0578 0.2373
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.0578 0.3646
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0081
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0229 0.049
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0092 0.0181
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0155 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Echinococcus granulosus cathepsin b 0.1034 0.6343 0.8781
Onchocerca volvulus 0.0411 0.2437 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0046
Plasmodium falciparum heterochromatin protein 1 0.0079 0.0354 0.1452
Echinococcus granulosus cathepsin l1 0.0344 0.2013 0.2787
Entamoeba histolytica cysteine protease, putative 0.0115 0.0581 0.2384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0581 0.2384
Loa Loa (eye worm) hypothetical protein 0.0137 0.0714 0.1126
Loa Loa (eye worm) hypothetical protein 0.0115 0.0581 0.0916
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0069 0.0109
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0115 0.0581 0.0916
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0066 0.0104
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.0578 0.1274
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032 0.0056 0.0056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0101 0.0415
Echinococcus multilocularis chromobox protein 1 0.0079 0.0354 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Onchocerca volvulus Prolyl endopeptidase homolog 0.0133 0.0693 0.281
Brugia malayi Cathepsin L-like cysteine proteinase 0.0344 0.2013 0.3174
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0101 0.0415
Brugia malayi cathepsin L-like precursor 0.0344 0.2013 0.3174
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0092 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.1004 0.4122
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0068 0.0281 0.0443
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0036 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.1004 0.4122
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.1077 0.1077
Mycobacterium leprae conserved hypothetical protein 0.0115 0.0578 1
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0354 0.1452
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0115 0.0581 0.2384
Brugia malayi SWIRM domain containing protein 0.0152 0.081 0.1278
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0115 0.0581 0.2384
Loa Loa (eye worm) matrixin family protein 0.0099 0.0478 0.0754
Echinococcus granulosus Chromo domain 0.0079 0.0354 0.049
Schistosoma mansoni hypothetical protein 0.0035 0.0078 0.0108
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Leishmania major hypothetical protein, conserved 0.0078 0.0349 0.1432
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0027 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0115 0.0581 0.2384
Giardia lamblia Cysteine protease 0.0115 0.0581 0.2458
Brugia malayi amine oxidase, flavin-containing family protein 0.004 0.011 0.0174
Plasmodium falciparum plasmepsin X 0.0034 0.0069 0.0283
Giardia lamblia Cathepsin L-like protease 0.0115 0.0581 0.2458
Plasmodium falciparum serine repeat antigen 1 0.0115 0.0581 0.2384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0581 0.2384
Echinococcus multilocularis chromobox protein 1 0.0079 0.0354 0.0354
Onchocerca volvulus Matrix metalloproteinase homolog 0.0099 0.0478 0.1926
Echinococcus granulosus histone deacetylase 7 0.0041 0.0117 0.0162
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0092 0.0376
Echinococcus granulosus muscleblind protein 0.0149 0.0793 0.1098
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0069 0.0096
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0101 0.0415
Echinococcus granulosus GPCR family 2 0.0063 0.0254 0.0351
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0034 0.0069 0.0283
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Echinococcus granulosus lysine specific histone demethylase 1A 0.0028 0.0036 0.005
Onchocerca volvulus 0.0411 0.2437 1
Schistosoma mansoni glutamate receptor AMPA 0.0027 0.0024 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Brugia malayi Matrixin family protein 0.0045 0.0137 0.0217
Mycobacterium ulcerans oxidoreductase 0.0028 0.0036 0.016
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0079 0.0354 0.049
Loa Loa (eye worm) beta-lactamase 0.0115 0.0578 0.0912
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0504 0.0504
Giardia lamblia Cathepsin B precursor 0.0115 0.0581 0.2458
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0115 0.0581 0.2384
Trypanosoma brucei histone deacetylase 3 0.0041 0.0117 0.0479
Toxoplasma gondii aspartyl protease ASP1 0.0034 0.0069 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0115 0.0581 0.0916
Brugia malayi RNA, U transporter 1 0.0088 0.0408 0.0643
Trypanosoma brucei oligopeptidase b 0.0053 0.019 0.0778
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0011 0.0046
Echinococcus granulosus glutamate receptor 2 0.0076 0.0336 0.0465
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0036 0.0148
Echinococcus multilocularis cathepsin L 0.0115 0.0581 0.0581
Schistosoma mansoni hypothetical protein 0.0063 0.0254 0.0351
Loa Loa (eye worm) hypothetical protein 0.0045 0.0138 0.0218
Echinococcus granulosus cathepsin L 0.0183 0.1004 0.1391
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0104
Schistosoma mansoni glutamate receptor AMPA 0.0027 0.0024 0.0033
Brugia malayi SET domain containing protein 0.0079 0.0354 0.0558
Mycobacterium tuberculosis Conserved protein 0.0115 0.0578 0.1274
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0155 0.0214
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0069 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Trypanosoma cruzi oligopeptidase b 0.0053 0.019 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Leishmania major DNA polymerase eta, putative 0.0039 0.0101 0.0415
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0092 0.0376
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Mycobacterium tuberculosis Probable peptidase 0.0053 0.019 0.0401
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032 0.0056 0.0077
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0079 0.0354 0.1452
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.1034 0.6343 1
Echinococcus granulosus histone deacetylase 6 0.0041 0.0117 0.0162
Loa Loa (eye worm) hypothetical protein 0.0092 0.0435 0.0687
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0133 0.0693 0.0959
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0101 0.0415
Giardia lamblia Cathepsin B precursor 0.0399 0.2363 1
Onchocerca volvulus 0.0344 0.2013 0.8254
Giardia lamblia Cathepsin L precursor 0.0115 0.0581 0.2458
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0101 0.016
Plasmodium falciparum serine repeat antigen 2 0.0115 0.0581 0.2384
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0229 0.1402
Entamoeba histolytica cysteine protease, putative 0.0115 0.0581 0.2384
Toxoplasma gondii prolyl endopeptidase 0.0133 0.0693 0.2843
Brugia malayi prolyl oligopeptidase family protein 0.0133 0.0693 0.1092
Echinococcus granulosus histone deacetylase 6 0.0041 0.0117 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Echinococcus granulosus cathepsin L cysteine protease 0.0183 0.1004 0.1391
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0046
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0092 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0137 0.0217
Echinococcus multilocularis cysteine protease 0.0411 0.2437 0.2437
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Brugia malayi Papain family cysteine protease containing protein 0.0411 0.2437 0.3842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Leishmania major pyruvate kinase 0.0033 0.0066 0.0271
Trypanosoma brucei unspecified product 0.0039 0.0101 0.0415
Mycobacterium ulcerans dehydrogenase 0.0028 0.0036 0.016
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0115 0.0581 0.0804
Plasmodium vivax vivapain-1 0.0183 0.1004 0.4122
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0578 0.0912
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Schistosoma mansoni cathepsin S (C01 family) 0.0115 0.0581 0.0804
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.0578 0.0912
Plasmodium vivax unspecified product 0.0068 0.0281 0.1154
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0115 0.0581 0.2384
Trypanosoma brucei prolyl endopeptidase 0.0133 0.0693 0.2843
Brugia malayi hypothetical protein 0.0034 0.0069 0.0109
Schistosoma mansoni hypothetical protein 0.0063 0.0254 0.0351
Entamoeba histolytica cysteine protease, putative 0.0115 0.0581 0.2384
Plasmodium falciparum serine repeat antigen 6 0.0115 0.0581 0.2384
Plasmodium falciparum pyruvate kinase 0.0033 0.0066 0.0271
Giardia lamblia Cathepsin B precursor 0.0399 0.2363 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0069 0.0069
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0254 0.04
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Trypanosoma cruzi prolyl endopeptidase 0.0133 0.0693 0.1092
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0066 0.0227
Chlamydia trachomatis pyruvate kinase 0.0033 0.0066 1
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0354 0.1452
Brugia malayi cathepsin L-like cysteine proteinase 0.0115 0.0581 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032 0.0056 0.0077
Brugia malayi Histone deacetylase family protein 0.0041 0.0117 0.0184
Brugia malayi hypothetical protein 0.0079 0.0354 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0344 0.2013 0.8262
Trypanosoma cruzi oligopeptidase b 0.0053 0.019 0.0299
Echinococcus granulosus pyruvate kinase 0.0033 0.0066 0.0092
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0101 0.014
Echinococcus multilocularis geminin 0.0536 0.3221 0.3221
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0101 0.0415
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0296 0.1713 0.2371
Echinococcus granulosus glutamate receptor subunit protein glur 0.0055 0.02 0.0276
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0092 0.0517
Loa Loa (eye worm) hypothetical protein 0.0344 0.2013 0.3174
Giardia lamblia Cathepsin L precursor 0.0115 0.0581 0.2458
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0578 0.0912
Plasmodium falciparum protoporphyrinogen oxidase 0.0028 0.0036 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0026 0.0105
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0115 0.0581 0.0804
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.111 0.175
Loa Loa (eye worm) histone deacetylase 7A 0.0041 0.0117 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0504 0.0698
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Plasmodium falciparum histone deacetylase, putative 0.0041 0.0117 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.1004 0.4122
Loa Loa (eye worm) glutamate receptor 2 0.0027 0.0024 0.0038
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0028 0.0036 0.0148
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0101 0.0579
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0254 0.0351
Schistosoma mansoni cathepsin C 0.0115 0.0581 0.0804
Leishmania major histone deacetylase, putative 0.0041 0.0117 0.0479
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Giardia lamblia Cathepsin B precursor 0.0115 0.0581 0.2458
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0196 0.0271
Schistosoma mansoni chromobox protein 0.1174 0.7224 1
Brugia malayi beta-lactamase family protein 0.0115 0.0578 0.0912
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.019 0.0778
Leishmania major importin beta-1 subunit, putative 0.0025 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.0133 0.0693 0.1092
Echinococcus granulosus chromobox protein 2 0.1174 0.7224 1
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0349 0.1432
Entamoeba histolytica cysteine protease, putative 0.0115 0.0581 0.2384
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0092 0.0144
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0066 0.0271
Trypanosoma brucei unspecified product 0.0027 0.0026 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Plasmodium vivax aspartyl protease, putative 0.0034 0.0069 0.0283
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0254 0.04
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0115 0.0581 0.2458
Brugia malayi fibroinase precursor 0.0115 0.0581 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0115 0.0581 0.2384
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0578 0.2373
Schistosoma mansoni DNA polymerase eta 0.0039 0.0101 0.014
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0101 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Loa Loa (eye worm) cysteine protease 0.0411 0.2437 0.3842
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0354 0.1452
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Echinococcus granulosus glutamate receptor 2 0.0066 0.0274 0.038
Brugia malayi Importin beta-1 subunit 0.0031 0.0051 0.0081
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0028 0.0036 0.016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0115 0.0581 0.0804
Plasmodium falciparum serine repeat antigen 3 0.0115 0.0581 0.2384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Plasmodium vivax serine-repeat antigen (SERA) 0.0115 0.0581 0.2384
Giardia lamblia Cathepsin B precursor 0.0115 0.0581 0.2458
Echinococcus granulosus Chromobox protein 3 0.0079 0.0354 0.049
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0079 0.0354 0.0354
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.072 0.1136
Onchocerca volvulus 0.0411 0.2437 1
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0578 0.2373
Schistosoma mansoni ATP-binding cassette transporter 0.0027 0.0024 0.0033
Plasmodium falciparum plasmepsin I 0.0034 0.0069 0.0283
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1004 0.4122
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0578 0.2373
Brugia malayi cathepsin F-like cysteine proteinase 0.0068 0.0281 0.0443
Schistosoma mansoni hypothetical protein 0.0536 0.3221 0.4459
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0581 0.2384
Trichomonas vaginalis Heterochromatin protein, putative 0.0079 0.0354 0.1452
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.021
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.1004 0.1391
Loa Loa (eye worm) hypothetical protein 0.0047 0.0155 0.0244
Onchocerca volvulus 0.0079 0.0354 0.1412
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.0578 0.1274
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0254 0.0254
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Echinococcus multilocularis glutamate receptor 4 0.0045 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.02 0.111 0.175
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0479 0.0662
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0254 0.04
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0092 0.0092
Brugia malayi Papain family cysteine protease containing protein 0.0115 0.0581 0.0916
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1034 0.6343 0.8781
Giardia lamblia Cathepsin L precursor 0.0115 0.0581 0.2458
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0155 0.0214
Echinococcus granulosus glutamate receptor 4 0.0045 0.0138 0.0191
Loa Loa (eye worm) hypothetical protein 0.0115 0.0578 0.0912
Plasmodium falciparum serine repeat antigen 9 0.0115 0.0581 0.2384
Onchocerca volvulus Cathepsin L homolog 0.0411 0.2437 1
Brugia malayi hypothetical protein 0.0051 0.0175 0.0276
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0066 0.0104
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0155 0.0214
Schistosoma mansoni chromobox protein 0.0079 0.0354 0.049
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0115 0.0581 0.0916
Giardia lamblia Cathepsin B precursor 0.0115 0.0581 0.2458
Giardia lamblia Cathepsin L-like protease 0.0115 0.0581 0.2458
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.2437 0.3842
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0101 0.0202
Schistosoma mansoni amine oxidase 0.0028 0.0036 0.005
Loa Loa (eye worm) fibroinase 0.0411 0.2437 0.3842
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0101 0.016
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.0354 0.1412
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0115 0.0581 0.2384
Brugia malayi Matrixin family protein 0.0108 0.0534 0.0842
Leishmania major DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0115 0.0581 0.0804
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.1004 0.1391
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0003 0.0012
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.019 0.0299
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0115 0.0581 0.0804
Mycobacterium tuberculosis Conserved protein 0.0115 0.0578 0.1274
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0196 0.0271
Trypanosoma brucei histone deacetylase, putative 0.0041 0.0117 0.0479
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0092 0.0376
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Onchocerca volvulus 0.0034 0.0069 0.0238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0504 0.0698
Brugia malayi Glutamate receptor 1 precursor 0.0071 0.0305 0.048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1034 0.6343 0.8781
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0133 0.0693 0.2843
Giardia lamblia DINP protein human, muc B family 0.0039 0.0101 0.0428
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.1004 0.1584
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.0578 0.1274
Trypanosoma cruzi cysteine proteinase, putative 0.0183 0.1004 0.1584
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0115 0.0581 0.0916
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0155 0.0592
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0115 0.0581 0.0804
Echinococcus multilocularis cathepsin L cysteine protease 0.0411 0.2437 0.2437
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0115 0.0581 0.2384
Echinococcus multilocularis snurportin 1 0.0329 0.1925 0.1925
Echinococcus granulosus pyruvate kinase 0.0033 0.0066 0.0092
Loa Loa (eye worm) hypothetical protein 0.0041 0.0117 0.0184
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0155 0.0155
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0024 0.0033
Toxoplasma gondii cathepsin CPC2 0.0115 0.0581 0.2384
Loa Loa (eye worm) hypothetical protein 0.0045 0.0137 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0115 0.0581 0.2384
Giardia lamblia Pyruvate kinase 0.0033 0.0066 0.028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0399 0.2363 0.3271
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0578 0.2373
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1034 0.6343 0.8781
Loa Loa (eye worm) hypothetical protein 0.0344 0.2013 0.3174
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Schistosoma mansoni cathepsin F (C01 family) 0.0411 0.2437 0.3373
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0109
Echinococcus granulosus dna polymerase kappa 0.0039 0.0101 0.014
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0092 0.0144
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.2437 0.3842
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0028 0.0036 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0066 0.0227
Onchocerca volvulus Matrilysin homolog 0.0045 0.0137 0.0521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0504 0.0698
Entamoeba histolytica hypothetical protein 0.0079 0.0354 0.1452
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Giardia lamblia Cathepsin L precursor 0.0115 0.0581 0.2458
Echinococcus granulosus cathepsin l cysteine peptidase 0.0411 0.2437 0.3373
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0069 0.0096
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0028 0.0036 0.0438
Loa Loa (eye worm) cathepsin B 0.0399 0.2363 0.3725
Loa Loa (eye worm) hypothetical protein 0.0045 0.0138 0.0218
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0133 0.0693 0.0959
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0066 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Trypanosoma cruzi cysteine proteinase, putative 0.0183 0.1004 0.1584
Schistosoma mansoni ap endonuclease 0.0037 0.0092 0.0127
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0155 0.0155
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0115 0.0578 0.0912
Schistosoma mansoni chromobox protein 0.0079 0.0354 0.049
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0155 0.0244
Brugia malayi Heterochromatin protein 1 0.0079 0.0354 0.0558
Loa Loa (eye worm) hypothetical protein 0.0115 0.0578 0.0912
Brugia malayi beta-lactamase family protein 0.0115 0.0578 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0581 0.2384
Loa Loa (eye worm) CHromoDomain protein family member 0.0079 0.0354 0.0558
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0066 0.0104
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1004 0.4122
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0066 0.0271
Mycobacterium tuberculosis Possible oxidoreductase 0.0028 0.0036 0.0056
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0793 0.0793
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0069 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0344 0.2013 0.8262
Plasmodium vivax importin-beta 2, putative 0.0031 0.0051 0.021
Loa Loa (eye worm) hypothetical protein 0.0115 0.0581 0.0916
Echinococcus granulosus glutamate NMDA receptor subunit 0.0027 0.0024 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0011 0.0046
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0399 0.2363 0.9697
Brugia malayi Cathepsin L-like precursor 0.0411 0.2437 0.3842
Loa Loa (eye worm) hypothetical protein 0.0149 0.0793 0.125
Brugia malayi M-phase phosphoprotein, mpp8 0.0079 0.0354 0.0558
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0504 0.0698
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0117 0.0117
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0015 0.0023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0115 0.0581 0.0804
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0411 0.2437 0.3842
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0115 0.0581 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0069 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0581 0.2384
Plasmodium vivax vivapain-2 0.0411 0.2437 1
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0015 0.006
Loa Loa (eye worm) matrix metalloproteinase 0.0045 0.0137 0.0217
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0411 0.2437 0.2437
Onchocerca volvulus 0.0063 0.0254 0.1003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0115 0.0581 0.2384
Echinococcus granulosus chromobox protein 1 0.0079 0.0354 0.049
Plasmodium falciparum plasmepsin V 0.0034 0.0069 0.0283
Loa Loa (eye worm) hypothetical protein 0.0115 0.0578 0.0912
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0079 0.0354 0.1452
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.1004 0.1391
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0076 0.0336 0.0336
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0411 0.2437 0.2437
Echinococcus multilocularis Chromobox protein 3 0.0079 0.0354 0.0354
Plasmodium falciparum cysteine proteinase falcipain 1 0.0183 0.1004 0.4122
Schistosoma mansoni importin beta-1 0.0031 0.0051 0.0071
Mycobacterium leprae Probable lipase LipE 0.0115 0.0578 1
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.0578 0.1274
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0117 0.0184
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0354 0.0558
Echinococcus granulosus histone deacetylase 6 0.0041 0.0117 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Echinococcus granulosus importin subunit beta 1 0.0031 0.0051 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Toxoplasma gondii cathepsin CPC1 0.0115 0.0581 0.2384
Echinococcus granulosus dna polymerase eta 0.0039 0.0101 0.014
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.021
Echinococcus granulosus cathepsin b 0.1034 0.6343 0.8781
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0229 0.0317
Loa Loa (eye worm) hypothetical protein 0.0068 0.0281 0.0443
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0115 0.0581 0.0804
Loa Loa (eye worm) hypothetical protein 0.0344 0.2013 0.3174
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0435 0.0603
Schistosoma mansoni hypothetical protein 0.0536 0.3221 0.4459
Entamoeba histolytica hypothetical protein 0.0079 0.0354 0.1452
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.0578 0.0578
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0581 0.2384
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0117 0.0184
Leishmania major cysteine peptidase A (CPA) 0.0411 0.2437 1
Giardia lamblia Cathepsin B precursor 0.0399 0.2363 1
Plasmodium vivax vivapain-3 0.0183 0.1004 0.4122
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0399 0.2363 0.9697
Schistosoma mansoni hypothetical protein 0.0137 0.0714 0.0988
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0069 0.0283
Trypanosoma cruzi UDP-galactopyranose mutase 0.0028 0.0036 0.0057
Schistosoma mansoni memapsin-2 (A01 family) 0.0839 0.5124 0.7093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Plasmodium vivax heterochromatin protein 1, putative 0.0079 0.0354 0.1452
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0101 0.016
Loa Loa (eye worm) hypothetical protein 0.014 0.0736 0.1161
Trypanosoma brucei histone deacetylase 4 0.0041 0.0117 0.0479
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0101 0.014
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0196 0.0309
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0115 0.0581 0.2384
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.111 0.175
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0109
Schistosoma mansoni hypothetical protein 0.0063 0.0254 0.0351
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0092 0.0127
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0003 0.0005
Echinococcus granulosus lysine specific histone demethylase 1A 0.014 0.0736 0.1019
Onchocerca volvulus Matrilysin homolog 0.0099 0.0478 0.1926
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0028 0.0036 0.0148
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0196 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0115 0.0581 0.2384
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.0504 0.0795
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0101 0.014
Echinococcus multilocularis cathepsin L cysteine protease 0.0411 0.2437 0.2437
Plasmodium falciparum serine repeat antigen 8 0.0115 0.0581 0.2384
Brugia malayi cathepsin Z-like cysteine proteinase 0.0115 0.0581 0.0916
Loa Loa (eye worm) hypothetical protein 0.004 0.011 0.0174
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.1077 0.149
Onchocerca volvulus 0.0079 0.0354 0.1412
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0028 0.0036 0.016
Onchocerca volvulus 0.0115 0.0578 0.2338
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0115 0.0581 0.2458
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0578 0.2373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0504 0.0698
Trypanosoma cruzi cysteine peptidase, putative 0.0183 0.1004 0.1584
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Echinococcus multilocularis Chromo domain 0.0079 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0063 0.0254 0.0351
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0115 0.0581 0.2384
Onchocerca volvulus 0.0411 0.2437 1
Onchocerca volvulus 0.0411 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0109
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0066 0.0353
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0069 0.0283
Echinococcus multilocularis cathepsin b 0.1034 0.6343 0.6343
Mycobacterium ulcerans lipase LipD 0.0115 0.0578 0.3646
Brugia malayi Pepsin A precursor 0.0034 0.0069 0.0109
Trypanosoma brucei cysteine peptidase C (CPC) 0.0399 0.2363 0.9697
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0115 0.0581 0.2384
Onchocerca volvulus 0.0034 0.0069 0.0238
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0079 0.0354 0.049
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0117 0.0184
Plasmodium falciparum plasmepsin III 0.0034 0.0069 0.0283
Loa Loa (eye worm) hypothetical protein 0.0045 0.0137 0.0217
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0024 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0015 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0349 0.055
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0162 0.0875 0.0875
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Toxoplasma gondii ABC1 family protein 0.0115 0.0578 0.2373
Toxoplasma gondii histone deacetylase HDAC1 0.0041 0.0117 0.0479
Brugia malayi Cathepsin L-like precursor 0.0344 0.2013 0.3174
Entamoeba histolytica cysteine proteinase, putative 0.0411 0.2437 1
Onchocerca volvulus 0.0152 0.081 0.3295
Brugia malayi Cathepsin L-like precursor 0.0411 0.2437 0.3842
Brugia malayi Trypsin family protein 0.0092 0.0435 0.0687
Leishmania major histone deacetylase, putative 0.0041 0.0117 0.0479
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.0435 0.0603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Brugia malayi hypothetical protein 0.0034 0.0069 0.0109
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0115 0.0581 0.2384
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0115 0.0581 0.0804
Brugia malayi CHD4 protein 0.0079 0.0354 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0581 0.2384
Loa Loa (eye worm) hypothetical protein 0.0152 0.081 0.1278
Loa Loa (eye worm) hypothetical protein 0.0068 0.0281 0.0443
Giardia lamblia Hypothetical protein 0.0115 0.0581 0.2458
Schistosoma mansoni glutamate receptor NMDA 0.0032 0.0056 0.0077
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0349 0.1432
Plasmodium falciparum plasmepsin II 0.0034 0.0069 0.0283
Loa Loa (eye worm) hypothetical protein 0.0045 0.0138 0.0218
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.0578 0.2373
Echinococcus multilocularis cathepsin b 0.1034 0.6343 0.6343
Schistosoma mansoni histone deacetylase 4 5 0.0041 0.0117 0.0162
Brugia malayi cathepsin Z-like cysteine proteinase 0.0115 0.0581 0.0916
Plasmodium falciparum plasmepsin VII 0.0034 0.0069 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.0504 0.0795
Loa Loa (eye worm) hypothetical protein 0.0115 0.0581 0.0916
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0078 0.0108
Brugia malayi hypothetical protein 0.0078 0.0349 0.055
Loa Loa (eye worm) hypothetical protein 0.0078 0.0349 0.055
Loa Loa (eye worm) hypothetical protein 0.0115 0.0581 0.0916
Onchocerca volvulus 0.0115 0.0578 0.2338
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0028 0.0036 0.016
Brugia malayi Protein cec-1. 0.0079 0.0354 0.0558
Trypanosoma cruzi cruzipain precursor, putative 0.0411 0.2437 0.3842
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0011 0.0046
Brugia malayi Cathepsin L-like precursor 0.0411 0.2437 0.3842
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0101 0.0579
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0055 0.02 0.02
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.0354 0.1412
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0066 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0026 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0026 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0079 0.0354 0.049
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0183 0.1004 0.1584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0581 0.2384
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0349 0.1432
Loa Loa (eye worm) matrixin family protein 0.0108 0.0534 0.0842
Brugia malayi Muscleblind-like protein 0.0149 0.0793 0.125
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0411 0.2437 1
Schistosoma mansoni cathepsin F (C01 family) 0.0411 0.2437 0.3373
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0053 0.019 0.3148
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Loa Loa (eye worm) hypothetical protein 0.0115 0.0581 0.0916
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0101 0.0415
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Schistosoma mansoni pyruvate kinase 0.0033 0.0066 0.0092
Brugia malayi Papain family cysteine protease containing protein 0.0115 0.0581 0.0916
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0101 0.016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0092 0.0387
Entamoeba histolytica cysteine protease, putative 0.0115 0.0581 0.2384
Loa Loa (eye worm) hypothetical protein 0.014 0.0736 0.1161
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0092 0.5
Echinococcus multilocularis muscleblind protein 0.0149 0.0793 0.0793
Leishmania major cathepsin L-like protease 0.0411 0.2437 1
Brugia malayi Cathepsin L-like precursor 0.0068 0.0281 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.019 0.0778
Loa Loa (eye worm) hypothetical protein 0.0041 0.0117 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0349 0.055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0115 0.0581 0.2384
Brugia malayi Associated with TFs and helicases family protein 0.0079 0.0354 0.0558
Giardia lamblia Cysteine protease 0.0115 0.0581 0.2458
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0057
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Echinococcus multilocularis cysteine protease 0.0411 0.2437 0.2437
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0399 0.2363 0.3725
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0229 0.0229
Giardia lamblia Cathepsin L precursor 0.0115 0.0581 0.2458
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0066 0.0104
Onchocerca volvulus 0.0086 0.0398 0.1594
Echinococcus multilocularis prolyl endopeptidase 0.0133 0.0693 0.0693
Plasmodium vivax plasmepsin V, putative 0.0034 0.0069 0.0283
Trypanosoma cruzi major cysteine proteinase, putative 0.0115 0.0581 0.0916
Toxoplasma gondii cathepsin CPL 0.0411 0.2437 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0115 0.0581 0.0916
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0578 0.08
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Giardia lamblia Encystation-specific protease 0.0115 0.0581 0.2458
Onchocerca volvulus Cathepsin L homolog 0.0115 0.0581 0.2349
Entamoeba histolytica hypothetical protein 0.0025 0.0015 0.006
Plasmodium falciparum cysteine proteinase falcipain 3 0.0411 0.2437 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0281 0.0443
Echinococcus multilocularis glutamate receptor 2 0.0076 0.0336 0.0336
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0079 0.0354 0.0558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0411 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0793 0.125
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.0578 0.1274
Schistosoma mansoni chromobox protein 0.0079 0.0354 0.049
Echinococcus multilocularis pyruvate kinase 0.0026 0.0022 0.0022
Onchocerca volvulus 0.0092 0.0435 0.1749
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0163 0.0257
Mycobacterium tuberculosis Probable oxidoreductase 0.0272 0.1566 0.3494
Trypanosoma cruzi cysteine protease, putative 0.0183 0.1004 0.1584
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0066 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Echinococcus multilocularis pyruvate kinase 0.0033 0.0066 0.0066
Echinococcus granulosus cathepsin L 0.0115 0.0581 0.0804
Plasmodium vivax unspecified product 0.0183 0.1004 0.4122
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0115 0.0581 0.2384
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0354 0.1452
Plasmodium vivax aspartyl protease, putative 0.0034 0.0069 0.0283
Mycobacterium ulcerans short chain dehydrogenase 0.0272 0.1566 1
Toxoplasma gondii exonuclease III APE 0.0037 0.0092 0.0376
Schistosoma mansoni cathepsin F (C01 family) 0.0344 0.2013 0.2787
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0229 0.0317
Loa Loa (eye worm) hypothetical protein 0.0092 0.0435 0.0687
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0115 0.0581 0.2384
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0057
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0066 0.0104
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0066 0.0271
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0079 0.0354 0.1452
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Echinococcus granulosus histone deacetylase 0.0041 0.0117 0.0162
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0028 0.0036 0.0148
Toxoplasma gondii histone lysine-specific demethylase 0.0028 0.0036 0.0148
Onchocerca volvulus 0.0045 0.0137 0.0521
Onchocerca volvulus 0.0047 0.0155 0.0592
Plasmodium falciparum serine repeat antigen 7 0.0115 0.0581 0.2384
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0066 0.0969
Trypanosoma cruzi UDP-galactopyranose mutase 0.0028 0.0036 0.0057
Onchocerca volvulus 0.0411 0.2437 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0054 0.0198 0.3303
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0054 0.0198 0.0421
Onchocerca volvulus 0.0411 0.2437 1
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0354 0.1452
Entamoeba histolytica hypothetical protein 0.0079 0.0354 0.1452
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1034 0.6343 1
Onchocerca volvulus 0.0099 0.0479 0.1927
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0411 0.2437 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0115 0.0581 0.2384
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0079 0.0354 0.049
Echinococcus multilocularis lysine specific histone demethylase 1A 0.014 0.0736 0.0736
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0411 0.2437 0.3842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0354 0.1452
Entamoeba histolytica cysteine proteinase, putative 0.0411 0.2437 1
Brugia malayi Cathepsin L-like precursor 0.0411 0.2437 0.3842
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0581 0.2384
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0411 0.2437 0.3842
Plasmodium vivax aspartyl protease, putative 0.0034 0.0069 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1004 0.4122
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0051 0.0051
Mycobacterium tuberculosis Conserved hypothetical protein 0.0028 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0005
Brugia malayi MH2 domain containing protein 0.0138 0.072 0.1136
Trypanosoma brucei unspecified product 0.0027 0.0026 0.0105
Plasmodium falciparum plasmepsin VI 0.0034 0.0069 0.0283
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0734 0.4462 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0411 0.2437 1
Brugia malayi Cathepsin L-like precursor 0.0344 0.2013 0.3174
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0115 0.0581 0.2384
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Schistosoma mansoni cathepsin B (C01 family) 0.0115 0.0581 0.0804
Schistosoma mansoni histone deacetylase hda2 0.0041 0.0117 0.0162
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0115 0.0581 0.2384
Echinococcus granulosus prolyl endopeptidase 0.0133 0.0693 0.0959
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.2437 0.3842
Mycobacterium ulcerans hypothetical protein 0.0115 0.0578 0.3646
Brugia malayi Matrixin family protein 0.0045 0.0137 0.0217
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0069 0.0109
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0155 0.0214
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032 0.0056 0.0077
Loa Loa (eye worm) ctsf protein 0.0411 0.2437 0.3842
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0101 0.0415
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0115 0.0581 0.2384
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0101 0.0415
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0079 0.0354 0.1452
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0101 0.0415
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0036 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0354 0.1452
Entamoeba histolytica cysteine proteinase, putative 0.0344 0.2013 0.8262
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0066 0.0271
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0349 0.1432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0069 0.0109
Plasmodium vivax vivapain-2 0.0411 0.2437 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.072 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.2437 1
Brugia malayi cathepsin B-like cysteine proteinase 0.1034 0.6343 1
Schistosoma mansoni histone deacetylase 4 5 0.0041 0.0117 0.0162
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0714 0.1126
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0229 0.0317
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0254 0.0351
Mycobacterium ulcerans beta-lactamase 0.0115 0.0578 0.3646
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0117 0.0117
Loa Loa (eye worm) helicase 0.0079 0.0354 0.0558
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0354 0.1452
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0354 0.1452
Onchocerca volvulus Cathepsin F homolog 0.0411 0.2437 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0411 0.2437 0.3373
Loa Loa (eye worm) hypothetical protein 0.0115 0.0578 0.0912
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0229 0.1402
Schistosoma mansoni Lysine-specific histone demethylase 1 0.014 0.0736 0.1019
Echinococcus granulosus tumor protein p63 0.0676 0.4101 0.5677
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0069 0.0096
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Brugia malayi Valyl-tRNA synthetase 0.0079 0.0354 0.0558
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.0588 0.3709
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.1925 0.3034
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0092 0.0144
Plasmodium vivax histone deacetylase 2, putative 0.0041 0.0117 0.0479
Giardia lamblia Cathepsin L precursor 0.0115 0.0581 0.2458
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0281 0.0443
Loa Loa (eye worm) hypothetical protein 0.0063 0.0254 0.04
Echinococcus multilocularis histone deacetylase 0.0041 0.0117 0.0117
Echinococcus multilocularis cathepsin L 0.0183 0.1004 0.1004
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0411 0.2437 1
Entamoeba histolytica cysteine protease, putative 0.0411 0.2437 1
Plasmodium vivax plasmepsin IV, putative 0.0034 0.0069 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0115 0.0581 0.2384
Brugia malayi hypothetical protein 0.0028 0.0036 0.0057
Giardia lamblia Hypothetical protein 0.0115 0.0581 0.2458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.2437 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0344 0.2013 0.3174
Schistosoma mansoni hypothetical protein 0.0079 0.0354 0.049
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0281 0.0443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1034 0.6343 0.8781
Trichomonas vaginalis esterase, putative 0.0115 0.0578 0.2373
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0076 0.0336 0.0465
Plasmodium falciparum serine repeat antigen 4 0.0115 0.0581 0.2384
Echinococcus multilocularis 0.0028 0.0036 0.0036
Echinococcus multilocularis GPCR, family 2 0.0063 0.0254 0.0254
Schistosoma mansoni amine oxidase 0.0028 0.0036 0.005
Echinococcus granulosus cathepsin l1 0.0411 0.2437 0.3373
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0115 0.0581 0.0916
Brugia malayi Cytochrome P450 family protein 0.0049 0.0163 0.0257
Echinococcus granulosus geminin 0.0536 0.3221 0.4459
Loa Loa (eye worm) hypothetical protein 0.0079 0.0354 0.0558
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0115 0.0581 0.2458
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0092 0.0376
Entamoeba histolytica cysteine protease, putative 0.0183 0.1004 0.4122
Brugia malayi chromobox protein homolog 3 0.0079 0.0354 0.0558
Brugia malayi Matrixin family protein 0.0045 0.0137 0.0217
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0092 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0349 0.1432
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.019 0.0401
Toxoplasma gondii aspartyl protease 0.0034 0.0069 0.0283
Brugia malayi Cathepsin L-like precursor 0.0411 0.2437 0.3842
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.111 0.175

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.62 nM Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay ChEMBL. 20561788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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