Detailed information for compound 1224018

Basic information

Technical information
  • TDR Targets ID: 1224018
  • Name: (3R,3aR,7aR)-7a-methyl-2-(phenylmethyl)-3-[4- (trifluoromethyl)phenyl]-3,3a,6,7-tetrahydroi soindol-1-one
  • MW: 385.422 | Formula: C23H22F3NO
  • H donors: 0 H acceptors: 1 LogP: 5.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1ccc(cc1)[C@@H]1N(Cc2ccccc2)C(=O)[C@]2([C@H]1C=CCC2)C)(F)F
  • InChi: 1S/C23H22F3NO/c1-22-14-6-5-9-19(22)20(17-10-12-18(13-11-17)23(24,25)26)27(21(22)28)15-16-7-3-2-4-8-16/h2-5,7-13,19-20H,6,14-15H2,1H3/t19-,20-,22+/m0/s1
  • InChiKey: CQQQZCZQSNWEPY-JAXLGGSGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,3aR,7aR)-2-(benzyl)-7a-methyl-3-[4-(trifluoromethyl)phenyl]-3,3a,6,7-tetrahydroisoindol-1-one
  • KUC101283N
  • MLS000882829
  • SMR000465380

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0678 0.3045 0.3045
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0155 0.0634 0.0626
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0612 0.2738 0.6768
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Brugia malayi N-terminal motif family protein 0.0218 0.0925 0.0925
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0157 0.041
Loa Loa (eye worm) hypothetical protein 0.0438 0.1939 0.2863
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Toxoplasma gondii exonuclease III APE 0.0023 0.0025 0.0046
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0273 0.0273
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Echinococcus granulosus serine protein kinase ATM 0.0396 0.1746 0.174
Echinococcus multilocularis 0.0155 0.0634 0.0626
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.008
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0273 0.0393
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0086 0.0078
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0718 0.3229 0.688
Toxoplasma gondii target of rapamycin (TOR), putative 0.081 0.3655 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0155 0.0634 0.0626
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1357 0.2001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0867 0.3914 0.8353
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.1033 0.2164
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0634 0.0626
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0423 0.1868 0.3959
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.174
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.2278 0.4838
Brugia malayi hypothetical protein 0.0027 0.0044 0.0044
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0878 0.3968 0.8468
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0438 0.1939 0.5295
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0256 0.1101 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.012 0.0113
Onchocerca volvulus 0.0038 0.0097 0.0092
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0051 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Leishmania major phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Schistosoma mansoni hypothetical protein 0.0155 0.0634 0.0626
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Echinococcus granulosus neuropeptide s receptor 0.0568 0.2536 0.253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.1868 0.1868
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1033 0.4681 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0155 0.0634 0.5656
Mycobacterium ulcerans hypothetical protein 0.0038 0.0097 1
Onchocerca volvulus 0.0155 0.0634 0.4752
Loa Loa (eye worm) phosphatidylinositol 3 0.0893 0.4033 0.5968
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Mycobacterium ulcerans lipase LipD 0.0038 0.0097 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3788 0.3783
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0097 0.0855
Onchocerca volvulus 0.0155 0.0634 0.4752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.4028
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1238 0.2606
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1649 0.752 0.7518
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0286 0.1237 0.2715
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Loa Loa (eye worm) phosphatidylinositol 3 0.1001 0.4534 0.6711
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0256 0.1101 0.1094
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.1155 0.1701
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0863 0.6743
Brugia malayi Cytochrome P450 family protein 0.0019 0.0008 0.0008
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0256 0.1101 1
Toxoplasma gondii FATC domain-containing protein 0.0396 0.1746 0.4767
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0097 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Loa Loa (eye worm) hypothetical protein 0.006 0.0198 0.0281
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0157 0.015
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0051 0.0096
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0086 0.0078
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0025 0.0017
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0138 0.1048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Entamoeba histolytica hypothetical protein 0.0867 0.3914 0.8353
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0197 0.028
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0423 0.1868 0.3959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.3229 0.688
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0438 0.1939 0.4111
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0157 0.1231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Entamoeba histolytica hypothetical protein 0.0396 0.1746 0.3697
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.4111
Brugia malayi cytochrome P450 0.0019 0.0008 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0097 0.0855
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1033 0.4681 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Brugia malayi hypothetical protein 0.0043 0.012 0.012
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0097 0.0855
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Echinococcus granulosus GPCR family 2 0.0019 0.0008 0.0000061935
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Brugia malayi Pre-SET motif family protein 0.0251 0.1078 0.1078
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0827 0.3732 0.8229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.1033 0.2164
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Brugia malayi hypothetical protein 0.0148 0.0602 0.0602
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Brugia malayi Cytochrome P450 family protein 0.006 0.0197 0.0197
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0273 0.0393
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0256 0.1101 0.1101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0097 0.0855
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0727 0.0727
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Loa Loa (eye worm) hypothetical protein 0.0678 0.3045 0.4503
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0025 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1649 0.752 0.7518
Leishmania major phosphatidylinositol 3-kinase, putative 0.0256 0.1101 0.2416
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0157 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0423 0.1868 0.1862
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0086 0.0078
Trichomonas vaginalis esterase, putative 0.0038 0.0097 0.0155
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0025 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0017
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0138 0.0281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0423 0.1868 0.3959
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Mycobacterium ulcerans beta-lactamase 0.0038 0.0097 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0155 0.0634 0.0928
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0198 0.0281
Leishmania major hypothetical protein, conserved 0.0038 0.0097 0.0197
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0025 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0086 0.0215
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.1383
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Echinococcus multilocularis neuropeptide receptor A26 0.0568 0.2536 0.253
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0584 0.0855
Toxoplasma gondii ABC1 family protein 0.0038 0.0097 0.0244
Brugia malayi MH2 domain containing protein 0.0144 0.0584 0.0584
Loa Loa (eye worm) phosphatidylinositol 3 0.1483 0.6752 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0086 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0634 0.6011
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Loa Loa (eye worm) hypothetical protein 0.0241 0.1033 0.1519
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Loa Loa (eye worm) hypothetical protein 0.0355 0.1557 0.2296
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0157 0.0285
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0423 0.1868 0.1862
Loa Loa (eye worm) beta-lactamase 0.0038 0.0097 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0935 0.1954
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0097 0.0855
Leishmania major hypothetical protein, conserved 0.0155 0.0634 0.1383
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Mycobacterium leprae Probable lipase LipE 0.0038 0.0097 0.1422
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.4534 0.9684
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0893 0.4033 0.8894
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Trypanosoma cruzi target of rapamycin kinase 3 0.0827 0.3732 0.3727
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0097 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1078 0.1587
Onchocerca volvulus 0.0286 0.1238 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.2426 0.5156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Entamoeba histolytica protein kinase rad3, putative 0.0396 0.1746 0.3697
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0008 0.0000091757
Brugia malayi RNA binding protein 0.0076 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Schistosoma mansoni hypothetical protein 0.0043 0.012 0.0113
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0000091757
Echinococcus granulosus tar DNA binding protein 0.0076 0.0273 0.0265
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0893 0.4033 0.8608
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0321 0.1401 0.3433
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1033 0.4681 0.4681
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0025 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Echinococcus multilocularis geminin 0.0175 0.0728 0.0721
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0155 0.0634 0.1308
Loa Loa (eye worm) hypothetical protein 0.0041 0.011 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0268 0.1155 0.1148
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0584 0.0855
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0609 0.2728 0.5805
Loa Loa (eye worm) hypothetical protein 0.0218 0.0925 0.1359
Echinococcus granulosus neuropeptide receptor A26 0.0568 0.2536 0.253
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Brugia malayi TAR-binding protein 0.0076 0.0273 0.0273
Giardia lamblia Phosphatidylinositol 4-kinase 0.0155 0.0634 0.1519
Brugia malayi FAT domain containing protein 0.0283 0.1225 0.1225
Echinococcus multilocularis serine protein kinase ATM 0.0396 0.1746 0.174
Plasmodium vivax hypothetical protein 0.0155 0.0634 0.5656
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0241 0.1033 0.1026
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0256 0.1101 0.2312
Brugia malayi beta-lactamase 0.0038 0.0097 0.0097
Echinococcus multilocularis Zinc finger, PHD finger 0.0256 0.1101 0.1094
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.1225 0.2579
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0778 0.3505 0.7474
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0273 0.0265
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0157 0.041
Loa Loa (eye worm) acetyltransferase 0.0175 0.0727 0.1066
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0616 0.2759 0.2759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1357 0.1357
Plasmodium vivax SET domain protein, putative 0.0036 0.0086 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Schistosoma mansoni hypothetical protein 0.0283 0.1225 0.1219
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0827 0.3732 0.8229
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Leishmania major phosphatidylinositol kinase, putative 0.0155 0.0634 0.1383
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0273 0.0393
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1649 0.752 0.7518
Onchocerca volvulus 0.0038 0.0097 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2188 1 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0008 0.0000061935
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0256 0.1101 0.1094
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.012 0.0113
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0893 0.4033 0.8894
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0155 0.0634 0.1308
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0256 0.1101 0.1621
Loa Loa (eye worm) hypothetical protein 0.0155 0.0634 0.0928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0634 0.5656
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0256 0.1101 0.1094
Loa Loa (eye worm) hypothetical protein 0.0065 0.0221 0.0316
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0155 0.0634 0.0626
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0138 0.0242
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0097 0.0669
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.008 0.0072
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0025 0.0163
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0396 0.1746 0.174
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0504 0.2241 0.4934
Leishmania major cytochrome p450-like protein 0.0028 0.0051 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0025 0.1904
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0097 0.0855
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0097 0.0132
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0155 0.0634 0.0626
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0778 0.3505 0.7474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.2618 0.557
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0925 0.7278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Schistosoma mansoni hypothetical protein 0.0041 0.011 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0893 0.4033 0.4028
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0634 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0396 0.1746 0.2577
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.0099
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.3841
Echinococcus multilocularis neuropeptide s receptor 0.0568 0.2536 0.253
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0893 0.4033 0.4028
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959
Onchocerca volvulus 0.0038 0.0097 0.0092
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0053
Echinococcus granulosus geminin 0.0175 0.0728 0.0721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.0634 0.1308
Giardia lamblia GTOR 0.0893 0.4033 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0893 0.4033 0.8608
Giardia lamblia Hypothetical protein 0.0155 0.0634 0.1519
Brugia malayi Pre-SET motif family protein 0.0036 0.0086 0.0086
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0097 0.0197
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0198 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0727 0.0719
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.1049 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0396 0.1746 0.174
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0097 0.1422
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0116
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.0626
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1033 0.4681 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0704 0.0697
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0396 0.1746 0.174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0097 0.0855
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0155 0.0634 0.1383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Leishmania major hypothetical protein, unknown function 0.0155 0.0634 0.1383
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0025 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0037
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0051 0.4881
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1033 0.4681 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.8894
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0893 0.4033 0.8894
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.012 0.0113
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0727 0.0719
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0256 0.1101 0.2312
Loa Loa (eye worm) hypothetical protein 0.0283 0.1225 0.1805
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0044 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0893 0.4033 0.4033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0256 0.1101 0.2312

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0631 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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