Detailed information for compound 1228349

Basic information

Technical information
  • TDR Targets ID: 1228349
  • Name: 1,2-bis(4-methoxyphenyl)-N-(6-methylpyridin-2 -yl)-6-oxopiperidine-3-carboxamide
  • MW: 445.51 | Formula: C26H27N3O4
  • H donors: 1 H acceptors: 3 LogP: 3.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1C(CCC(=O)N1c1ccc(cc1)OC)C(=O)Nc1cccc(n1)C
  • InChi: 1S/C26H27N3O4/c1-17-5-4-6-23(27-17)28-26(31)22-15-16-24(30)29(19-9-13-21(33-3)14-10-19)25(22)18-7-11-20(32-2)12-8-18/h4-14,22,25H,15-16H2,1-3H3,(H,27,28,31)
  • InChiKey: LIISURJRXKPPMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,2-bis(4-methoxyphenyl)-N-(6-methyl-2-pyridyl)-6-oxo-piperidine-3-carboxamide
  • 1,2-bis(4-methoxyphenyl)-N-(6-methyl-2-pyridyl)-6-oxo-3-piperidinecarboxamide
  • 6-keto-1,2-bis(4-methoxyphenyl)-N-(6-methyl-2-pyridyl)nipecotamide
  • 1,2-bis(4-methoxyphenyl)-N-(6-methylpyridin-2-yl)-6-oxo-piperidine-3-carboxamide
  • MLS000090442
  • SMR000025052

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.007 0.0745 0.1393
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0142 0.0149
Leishmania major DNA polymerase eta, putative 0.0036 0.0298 0.0374
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0291 0.032
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0106 0.0242
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0026 0.0169 0.1153
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0503 0.1745
Schistosoma mansoni hypothetical protein 0.0024 0.0142 0.0149
Entamoeba histolytica hypothetical protein 0.0061 0.0627 0.508
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.1147
Brugia malayi RNA, U transporter 1 0.0086 0.0944 0.3603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1718 0.1947
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0031 0.0237 0.0298
Schistosoma mansoni regulator of G protein signaling 0.0061 0.0627 0.0702
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1233 0.1551
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0026 0.0169 0.1366
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.1453 0.2773
Trichomonas vaginalis ran, putative 0.0022 0.0122 0.0423
Leishmania major hypothetical protein, conserved 0.0015 0.0032 0.004
Echinococcus granulosus bloom syndrome protein 0.0024 0.0144 0.0151
Echinococcus multilocularis GPCR, family 2 0.0035 0.0291 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0627 0.2174
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.0453 0.338
Trypanosoma brucei unspecified product 0.0023 0.0135 0.0169
Trypanosoma brucei phosphoglycerate kinase 0.0085 0.093 0.1169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0219 0.0237
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1233 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0627 0.1162
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.1171 0.1473
Loa Loa (eye worm) RGS-3 protein 0.0061 0.0627 0.1162
Echinococcus multilocularis cpg binding protein 0.0035 0.0291 0.028
Echinococcus granulosus dna polymerase kappa 0.006 0.0612 0.0685
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0086 0.0108
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0142 0.0491
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.0453 0.0569
Brugia malayi Pre-SET motif family protein 0.0207 0.2512 1
Schistosoma mansoni regulator of G protein signaling 0.0061 0.0627 0.0702
Trichomonas vaginalis dullard protein, putative 0.0026 0.0169 0.0585
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1171 0.4064
Echinococcus granulosus regulator of G protein signaling 7 0.0061 0.0627 0.0702
Schistosoma mansoni chromobox protein 0.0145 0.1708 0.1936
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.01 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1718 0.1947
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0142 0.0332
Trypanosoma brucei ISWI complex protein 0.0015 0.0032 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1233 0.4279
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0597 0.219
Echinococcus granulosus Regulator of G protein signaling 20 0.0061 0.0627 0.0702
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0088 0.0088
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0061 0.0627 0.0702
Loa Loa (eye worm) hypothetical protein 0.0081 0.0885 0.1665
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0169 0.0585
Plasmodium vivax importin-beta 2, putative 0.003 0.0225 0.2044
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0061 0.0627 0.0702
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0438 0.0428
Schistosoma mansoni lamin 0.0033 0.0255 0.0279
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0142 0.0659
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491
Echinococcus granulosus importin subunit beta 1 0.003 0.0225 0.0244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1277 0.243
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1233 0.4279
Echinococcus granulosus intermediate filament protein 0.0033 0.0255 0.0279
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0091 0.0062
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0088 0.0422
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1233 0.4279
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.0252
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1233 0.1551
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0122 0.0111
Giardia lamblia PHD finger protein 15 0.0061 0.0619 0.4908
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0086 0.0108
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0026 0.0169 0.0212
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0782 0.6711
Echinococcus granulosus lamin 0.0033 0.0255 0.0279
Brugia malayi SET domain containing protein 0.0025 0.0156 0.0389
Schistosoma mansoni DNA polymerase eta 0.0059 0.0597 0.0669
Trypanosoma brucei unspecified product 0.0023 0.0135 0.0169
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0219 0.0208
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.0527 0.0662
Brugia malayi chromobox protein homolog 3 0.0081 0.0885 0.3362
Giardia lamblia Phosphoglycerate kinase 0.0085 0.093 0.7774
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0217
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0213 0.0738
Echinococcus granulosus regulator of G protein signaling 3 0.0061 0.0627 0.0702
Entamoeba histolytica phosphoglycerate kinase, putative 0.0085 0.093 0.7538
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1233 0.2345
Brugia malayi intermediate filament protein 0.0033 0.0255 0.0796
Leishmania major importin beta-1 subunit, putative 0.0024 0.0151 0.019
Echinococcus granulosus G protein coupled receptor kinase 1 0.0351 0.437 0.4974
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0808 0.0909
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.1147
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1171 0.1473
Echinococcus granulosus axis inhibition protein axin 0.0061 0.0627 0.0702
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0142 0.0332
Echinococcus granulosus chromobox protein 1 0.0145 0.1708 0.1936
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0213 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1171 0.4064
Onchocerca volvulus 0.0064 0.0658 0.1884
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1233 0.2345
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0612 0.2122
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1233 0.2851
Brugia malayi Pre-SET motif family protein 0.003 0.0219 0.0648
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0217
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0213 0.0738
Echinococcus granulosus expressed protein 0.0446 0.5589 0.6365
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0503 0.1745
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.1718 0.3289
Brugia malayi 6-phosphofructokinase 0.0108 0.1233 0.4784
Loa Loa (eye worm) hypothetical protein 0.0061 0.0627 0.1162
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0413 0.5161 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1171 0.4064
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0088 0.0422
Echinococcus multilocularis chromobox protein 1 0.0145 0.1708 0.1698
Entamoeba histolytica hypothetical protein 0.0024 0.0142 0.1147
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1233 0.1223
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0088 0.0111
Echinococcus multilocularis Chromo domain 0.0024 0.0142 0.013
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0085 0.093 0.3226
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.004
Onchocerca volvulus 0.0033 0.0255 0.0416
Leishmania major hypothetical protein, conserved 0.0026 0.0169 0.0212
Echinococcus multilocularis regulator of G protein signaling 7 0.0061 0.0627 0.0616
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.006 0.0058
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0453 0.0504
Brugia malayi hypothetical protein 0.002 0.0089 0.0116
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.0331 0.1102
Brugia malayi Regulator of G protein signaling domain containing protein 0.0061 0.0627 0.2309
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1233 0.1395
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0142 0.1103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0782 0.1728
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1233 0.1551
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1233 1
Entamoeba histolytica hypothetical protein 0.0061 0.0627 0.508
Brugia malayi hypothetical protein 0.003 0.0228 0.0684
Brugia malayi Regulator of G protein signaling domain containing protein 0.0061 0.0627 0.2309
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0061 0.0627 0.0702
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0351 0.437 0.4363
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0453 0.1601
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0091 0.0451
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0926 0.1043
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0213 0.1907
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0213 0.1907
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1171 0.1473
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0169 0.0212
Loa Loa (eye worm) hypothetical protein 0.012 0.139 0.2649
Leishmania major GTP-binding protein, putative 0.0022 0.0122 0.0153
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0038 0.0331 0.0364
Entamoeba histolytica hypothetical protein 0.0035 0.0286 0.2319
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1171 0.4064
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0627 0.2174
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.013 0.0284
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0142 0.0659
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0086 0.0075
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0144 0.0133
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0088 0.0088
Brugia malayi Bromodomain containing protein 0.0063 0.0649 0.2401
Entamoeba histolytica hypothetical protein 0.0024 0.0142 0.1147
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0088 0.0113
Schistosoma mansoni hypothetical protein 0.0076 0.0821 0.0924
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1277 0.4962
Entamoeba histolytica hypothetical protein 0.0024 0.0142 0.1147
Schistosoma mansoni hypothetical protein 0.0322 0.3997 0.4549
Loa Loa (eye worm) hypothetical protein 0.0061 0.0627 0.1162
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0089 0.0112
Brugia malayi hypothetical protein 0.0061 0.0627 0.2309
Brugia malayi A-kinase anchor protein 10, precursor 0.0061 0.0627 0.2309
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0255 0.0796
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0142 0.0491
Echinococcus multilocularis expressed protein 0.0446 0.5589 0.5584
Onchocerca volvulus 0.0024 0.0142 0.000000058689
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1277 0.243
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0151 0.0524
Trypanosoma brucei unspecified product 0.0054 0.0527 0.0662
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.1171 0.3758
Mycobacterium ulcerans phosphoglycerate kinase 0.0085 0.093 0.2097
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0438 0.0487
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0026 0.0169 0.0157
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0026 0.0169 0.0179
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0088 0.0077
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0269 0.0259
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0217
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0291 0.028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0255 0.0439
Echinococcus multilocularis dna polymerase kappa 0.006 0.0612 0.0601
Brugia malayi Heterochromatin protein 1 0.0145 0.1708 0.6718
Plasmodium falciparum phd finger protein, putative 0.0061 0.0619 0.6313
Echinococcus multilocularis phosphoglycerate kinase 1 0.0085 0.093 0.092
Loa Loa (eye worm) hypothetical protein 0.0061 0.0619 0.1147
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0113
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0089 0.0089
Plasmodium vivax hypothetical protein, conserved 0.002 0.0091 0.0534
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0225 0.0283
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0169 0.0585
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1277 0.4962
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0453 0.0569
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1233 0.1395
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0199 0.2402 0.2728
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.1171 0.9497
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0228 0.0287
Loa Loa (eye worm) hypothetical protein 0.0061 0.0627 0.1162
Leishmania major modification methylase-like protein 0.002 0.0089 0.0112
Plasmodium falciparum importin beta, putative 0.003 0.0225 0.1647
Schistosoma mansoni lamin 0.0033 0.0255 0.0279
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0199 0.2402 0.2393
Trypanosoma brucei phosphoglycerate kinase 0.0085 0.093 0.1169
Onchocerca volvulus 0.0236 0.2882 1
Schistosoma mansoni regulator of G protein signaling 0.0061 0.0627 0.0702
Trichomonas vaginalis dullard protein, putative 0.0026 0.0169 0.0585
Brugia malayi Phosphoglycerate kinase 0.0031 0.0237 0.072
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0782 0.0771
Plasmodium vivax phosphoglycerate kinase, putative 0.0085 0.093 1
Brugia malayi PHD-finger family protein 0.0061 0.0619 0.2277
Loa Loa (eye worm) hypothetical protein 0.0041 0.0359 0.0641
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0142 0.013
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0091 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0354 0.0446
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.1171 0.2224
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0049
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1233 0.1395
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0026 0.0169 0.0442
Onchocerca volvulus Alhambra homolog 0.0061 0.0619 0.1741
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0169 0.0585
Loa Loa (eye worm) hypothetical protein 0.0047 0.0438 0.0796
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1718 0.1708
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Leishmania major DNA polymerase eta, putative 0.0059 0.0597 0.0751
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0782 0.0879
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0782 0.1728
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0213 0.1554
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Loa Loa (eye worm) hypothetical protein 0.0104 0.1178 0.2238
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0213 0.0738
Brugia malayi jmjC domain containing protein 0.002 0.0088 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0213 0.0738
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0054 0.0049
Echinococcus multilocularis Regulator of G protein signaling 20 0.0061 0.0627 0.0616
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0298 0.3677 0.4623
Schistosoma mansoni phosphoglycerate kinase 0.0085 0.093 0.1048
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0627 0.2174
Schistosoma mansoni serine/threonine protein kinase 0.0413 0.5161 0.5877
Echinococcus multilocularis 0.0026 0.0169 0.0157
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0354 0.0667
Echinococcus granulosus snurportin 1 0.0322 0.3997 0.4549
Schistosoma mansoni z-protein (S1r protein) 0.0061 0.0627 0.0702
Leishmania major phosphoglycerate kinase B, cytosolic 0.0085 0.093 0.1169
Echinococcus granulosus dna polymerase eta 0.0059 0.0597 0.0669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1718 0.1947
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0086 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0629 0.7953 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0142 0.0659
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0354 0.0446
Treponema pallidum phosphoglycerate kinase 0.0085 0.093 0.7354
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0225 0.1664
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0213 0.1554
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0286 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0055 0.0121
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0808 0.0909
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0424
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0453 0.0442
Trypanosoma brucei phosphoglycerate kinase, putative 0.0031 0.0237 0.0298
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0291 0.0509
Echinococcus multilocularis chromobox protein 1 0.0145 0.1708 0.1698
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0125 0.013
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0298 0.3677 0.4623
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.0269 0.2185
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0219 0.1611
Echinococcus granulosus axis inhibition protein axin 0.0061 0.0627 0.0702
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0225 0.0283
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0142 0.0908
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.1171 0.1324
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0821 0.3102
Schistosoma mansoni ap endonuclease 0.0019 0.0086 0.0085
Echinococcus multilocularis lamin 0.0033 0.0255 0.0244
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0122 0.0882
Echinococcus granulosus CTD small phosphatase protein like 0.0026 0.0169 0.0179
Entamoeba histolytica hypothetical protein 0.0061 0.0627 0.508
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0089 0.0089
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0085 0.093 0.2097
Schistosoma mansoni kinase 0.0053 0.052 0.0581
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1233 1
Chlamydia trachomatis phosphoglycerate kinase 0.0085 0.093 1
Entamoeba histolytica hypothetical protein 0.0035 0.0286 0.2319
Echinococcus granulosus beta-adrenergic receptor kinase 0.0413 0.5161 0.5877
Echinococcus granulosus peregrin 0.0063 0.0649 0.0728
Schistosoma mansoni cpg binding protein 0.0033 0.0266 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0228 0.0287
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0228 0.1692
Schistosoma mansoni hypothetical protein 0.0061 0.0619 0.0693
Schistosoma mansoni hypothetical protein 0.0026 0.0164 0.0175
Echinococcus multilocularis dna polymerase eta 0.0059 0.0597 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.0453 0.0504
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0085 0.093 0.8055
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0089 0.0433
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.1718 0.6759
Loa Loa (eye worm) hypothetical protein 0.0038 0.0329 0.0582
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0976 0.1228
Echinococcus multilocularis lamin dm0 0.0033 0.0255 0.0244
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0453 0.0569
Echinococcus multilocularis axis inhibition protein axin 0.0061 0.0627 0.0616
Loa Loa (eye worm) hypothetical protein 0.003 0.0228 0.0385
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.022 0.0276
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1233 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0086 0.0109
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0142 0.0491
Brugia malayi jmjC domain containing protein 0.002 0.0088 0.0113
Schistosoma mansoni axis inhibition protein axin 0.0061 0.0627 0.0702
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0151 0.0524
Onchocerca volvulus 0.0033 0.0266 0.0454
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0612 0.0769
Giardia lamblia DINP protein human, muc B family 0.004 0.0354 0.2473
Echinococcus granulosus chromobox protein 2 0.0024 0.0142 0.0149
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.1171 0.1161
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0031 0.0237 0.0298
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0088 0.0088
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0298 0.2323
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0151 0.019
Schistosoma mansoni cpg binding protein 0.0035 0.0291 0.0319
Schistosoma mansoni hypothetical protein 0.0692 0.8774 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0088 0.0111
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0782 0.1728
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1171 0.4064
Entamoeba histolytica Ran family GTPase 0.0022 0.0122 0.0989
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0612 0.0769
Brugia malayi regulator of G-protein signaling egl-10 0.0061 0.0627 0.2309
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0079 0.0077
Brugia malayi hypothetical protein 0.0061 0.0627 0.2309
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0085 0.093 0.3226
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0085 0.093 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0228 0.1684
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0627 0.2174
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0062 0.0063
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0269 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Echinococcus multilocularis phd:f box containing protein 0.002 0.0088 0.0077
Schistosoma mansoni chromobox protein 0.0024 0.0142 0.0149
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0213 0.1504
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0976 0.1228
Brugia malayi jmjC domain containing protein 0.0199 0.2402 0.9548
Schistosoma mansoni serine/threonine protein kinase 0.0413 0.5161 0.5877
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0169 0.0179
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0142 0.0908
Leishmania major phosphoglycerate kinase C, glycosomal 0.0085 0.093 0.1169
Trypanosoma brucei phosphoglycerate kinase 0.0031 0.0237 0.0298
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0169 0.1408
Echinococcus granulosus Chromobox protein 3 0.0024 0.0142 0.0149
Brugia malayi phosphofructokinase 0.0108 0.1233 0.4784
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0453 0.0504
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0286 0.0314
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0603 0.0675
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0144 0.0341
Echinococcus multilocularis axis inhibition protein axin 0.0061 0.0627 0.0616
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0291 0.0942
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491
Echinococcus granulosus PHD finger protein rhinoceros 0.0061 0.0619 0.0693
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0612 0.0769
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1718 0.1947
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1171 0.4064
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1233 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0145 0.1708 0.5925
Schistosoma mansoni zinc finger protein 0.002 0.0087 0.0086
Trypanosoma brucei polo-like protein kinase 0.0104 0.1171 0.1473
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1233 0.2851
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0038 0.0027
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0089 0.0722
Mycobacterium tuberculosis Conserved hypothetical protein 0.0331 0.4111 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0885 0.307
Echinococcus multilocularis chromobox protein 2 0.0024 0.0142 0.013
Loa Loa (eye worm) hypothetical protein 0.0085 0.093 0.1753
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0086 0.0475
Echinococcus multilocularis zinc finger protein 0.002 0.0087 0.0076
Echinococcus granulosus cpg binding protein 0.0035 0.0291 0.0319
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0142 0.0332
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2882 1
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0619 0.1147
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.0453 0.0442
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0167
Echinococcus granulosus geminin 0.0692 0.8774 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0297 0.0286
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0142 0.0149
Echinococcus multilocularis geminin 0.0692 0.8774 0.8773
Echinococcus granulosus zinc finger protein 0.002 0.0087 0.0086
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0061 0.0627 0.2174
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0228 0.0287
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0086 0.0696
Schistosoma mansoni bromodomain containing protein 0.0063 0.0649 0.0728
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0142 0.0332
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0088 0.0111
Schistosoma mansoni axis inhibition protein axin 0.0061 0.0627 0.0702
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0081 0.0885 0.2712
Loa Loa (eye worm) PXA domain-containing protein 0.0061 0.0627 0.1162
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0237 0.0298
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.0491
Schistosoma mansoni ap endonuclease 0.0019 0.0086 0.0085
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0612 0.2122
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0926 0.0915
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0291 0.028
Schistosoma mansoni chromobox protein 0.0024 0.0142 0.0149
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0808 0.0909
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0151 0.0524
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0612 0.0769
Loa Loa (eye worm) hypothetical protein 0.0048 0.0453 0.0824
Echinococcus granulosus phosphoglycerate kinase 1 0.0085 0.093 0.1048
Schistosoma mansoni zinc finger protein 0.0015 0.0032 0.0023
Brugia malayi PHD-finger family protein 0.0025 0.0155 0.0388
Trichomonas vaginalis dullard protein, putative 0.0026 0.0169 0.0585
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0144 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0627 0.2174
Schistosoma mansoni hypothetical protein 0.0035 0.0291 0.032
Loa Loa (eye worm) hypothetical protein 0.0059 0.0597 0.1105
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0142 0.0149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1718 0.1708
Onchocerca volvulus 0.0053 0.0526 0.1401
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.027
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0144 0.0499
Echinococcus multilocularis snurportin 1 0.0322 0.3997 0.399
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0782 0.0879
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0612 0.1306
Echinococcus multilocularis peregrin 0.0063 0.0649 0.0639
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.1147
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0453 0.1571
Brugia malayi PXA domain containing protein 0.0061 0.0627 0.2309
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0213 0.0738
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0269 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0578 0.2006
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.0976 0.1228
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0266 0.046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.0976 0.1228
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0063 0.0643 0.2378
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0627 0.2174
Echinococcus granulosus chromobox protein 1 0.0145 0.1708 0.1936
Brugia malayi CHD4 protein 0.0026 0.0166 0.0432
Brugia malayi CXXC zinc finger family protein 0.0033 0.0266 0.0839
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0619 0.5234
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0237 0.0298
Schistosoma mansoni jumonji domain containing protein 0.002 0.0088 0.0088
Brugia malayi 6-phosphofructokinase 0.0108 0.1233 0.4784
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0217
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0269 0.0295
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0619 0.5234
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0612 0.1306
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0089 0.0433
Schistosoma mansoni protein phosphatase 2C 0.002 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0331 0.0585
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1233 0.4279
Echinococcus granulosus lamin dm0 0.0033 0.0255 0.0279
Schistosoma mansoni cpg binding protein 0.0035 0.0291 0.0319
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0629 0.7953 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0453 0.1571
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0088 0.0088
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0213 0.1554
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0312 0.0392
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0142 0.0149
Brugia malayi jmjC domain containing protein 0.002 0.0088 0.0113
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0142 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.022 0.0276
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2512 0.4838
Loa Loa (eye worm) hypothetical protein 0.0076 0.0821 0.1541
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0089 0.0511
Loa Loa (eye worm) hypothetical protein 0.0061 0.0627 0.1162
Leishmania major mitochondrial DNA polymerase beta 0.0629 0.7953 1
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0085 0.093 0.8055
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0086 0.0298
Schistosoma mansoni intermediate filament proteins 0.0033 0.0255 0.0279
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1233 0.2345
Toxoplasma gondii hypothetical protein 0.0084 0.0924 0.7999
Leishmania major hypothetical protein, conserved 0.002 0.0088 0.0111
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0297 0.0326
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.0453 0.0504
Schistosoma mansoni phosphoglycerate kinase 0.0085 0.093 0.1048
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0091 0.0115
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0061 0.0619 0.0693
Loa Loa (eye worm) hypothetical protein 0.0064 0.0658 0.1223
Brugia malayi polk-prov protein 0.0037 0.0312 0.1027
Brugia malayi regulator of G-protein signaling rgs-7 0.0061 0.0627 0.2309
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0619 0.6488
Echinococcus multilocularis regulator of G protein signaling 3 0.0061 0.0627 0.0616
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0088 0.0077
Schistosoma mansoni hypothetical protein 0.0035 0.0291 0.032
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.0453 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0312 0.0392
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0782 0.0983
Echinococcus granulosus phd:f box containing protein 0.002 0.0088 0.0088
Brugia malayi Protein cec-1. 0.0024 0.0142 0.0332
Brugia malayi Importin beta-1 subunit 0.003 0.0225 0.0672
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0629 0.7953 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0125 0.0114
Schistosoma mansoni hypothetical protein 0.002 0.0091 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0088 0.0113
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.0153
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0061 0.0627 0.0702
Schistosoma mansoni regulator of G protein signaling 0.0061 0.0627 0.0702
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0782 0.0879
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0113 0.0116
Echinococcus granulosus Chromo domain 0.0024 0.0142 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Mycobacterium ulcerans hypothetical protein 0.0331 0.4111 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0384 0.0689
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0088 0.0077
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0086 0.0298
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0038 0.003
Schistosoma mansoni hypothetical protein 0.0035 0.0286 0.0314
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0142 0.0491
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0061 0.0627 0.1162
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0643 0.0721
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0169 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Brugia malayi Bromodomain containing protein 0.0038 0.0328 0.1091
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0237 0.0298
Schistosoma mansoni ran 0.0022 0.0122 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0053 0.0526 0.0587
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0122 0.0731
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0291 0.0942
Brugia malayi PXA domain containing protein 0.0061 0.0627 0.2309
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0122 0.0126
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0298 0.0374
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0023
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0026 0.0169 0.0761
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0142 0.1103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0438 0.0487
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0113 0.0101
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.0269 0.0295
Brugia malayi PHD-finger family protein 0.0022 0.0116 0.0226
Entamoeba histolytica hypothetical protein 0.0035 0.0286 0.2319
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0453 0.0569
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0213 0.1169
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0169 0.1408
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0379
Loa Loa (eye worm) helicase 0.0024 0.0142 0.0217
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0269 0.0456
Giardia lamblia Kinase, PLK 0.0104 0.1171 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.0491
Loa Loa (eye worm) hypothetical protein 0.0026 0.0164 0.0262
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0088 0.0113
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0086 0.0105
Plasmodium falciparum phosphoglycerate kinase 0.0085 0.093 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0808 0.1516
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0166 0.0177
Echinococcus granulosus regulator of G protein signaling 7 0.0061 0.0627 0.0702
Loa Loa (eye worm) heterochromatin protein 1 0.0145 0.1708 0.3269
Entamoeba histolytica hypothetical protein 0.0024 0.0151 0.1226
Brugia malayi hypothetical protein 0.0024 0.0142 0.0332
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.0491
Onchocerca volvulus 0.0038 0.0331 0.069
Trypanosoma cruzi DNA polymerase eta, putative 0.0059 0.0597 0.0751
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1171 0.4064
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.0784 0.0773
Schistosoma mansoni hypothetical protein 0.0035 0.0291 0.032
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.0179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0105 0.0107
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0213 0.1504
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.0491
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0453 0.0442
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0054 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0964 0.3346
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0142 0.1103
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0089 0.0038
Echinococcus multilocularis regulator of G protein signaling 0.0061 0.0627 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0578 0.2006
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0885 0.307
Schistosoma mansoni phd/f-box containing protein 0.002 0.0088 0.0088
Echinococcus multilocularis PHD finger protein rhinoceros 0.0061 0.0619 0.0608
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0086 0.0108
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0091 0.0115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0286 0.0275
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0205 0.0221
Toxoplasma gondii exonuclease III APE 0.0019 0.0086 0.0404
Toxoplasma gondii hypothetical protein 0.0101 0.1144 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0255 0.0439
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0453 0.3671
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.0153
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.1171 0.4531
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0298 0.3677 0.4623
Trichomonas vaginalis chromobox protein, putative 0.0145 0.1708 0.5925
Leishmania major hypothetical protein, conserved 0.003 0.0228 0.0287
Schistosoma mansoni hypothetical protein 0.0692 0.8774 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0213 0.1725
Loa Loa (eye worm) hypothetical protein 0.0061 0.0627 0.1162
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.3997 0.7731
Echinococcus granulosus disco interacting protein 2 0.0038 0.0331 0.0364
Echinococcus granulosus GPCR family 2 0.0035 0.0291 0.032
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0087 0.0964 0.3003
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0125 0.013
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0088 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1718 0.1947
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0085 0.093 0.1169
Trypanosoma brucei DNA polymerase eta, putative 0.0059 0.0597 0.0751
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0061 0.0627 0.0616
Echinococcus multilocularis beta adrenergic receptor kinase 0.0413 0.5161 0.5156
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.1171 0.1324
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0213 0.1106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.1226 0.1542
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.0153
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.004
Brugia malayi hypothetical protein 0.0035 0.0286 0.0921
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0291 0.032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491
Schistosoma mansoni hypothetical protein 0.0035 0.0291 0.032
Schistosoma mansoni ran 0.0022 0.0122 0.0126
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0228 0.1684
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0255 0.0439
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0924 0.9927
Onchocerca volvulus 0.0033 0.0255 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Echinococcus multilocularis regulator of G protein signaling 7 0.0061 0.0627 0.0616
Echinococcus multilocularis importin subunit beta 1 0.003 0.0225 0.0214
Schistosoma mansoni regulator of G protein signaling 0.0061 0.0627 0.0702
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491
Echinococcus multilocularis musashi 0.0033 0.0255 0.0244
Schistosoma mansoni importin beta-1 0.003 0.0225 0.0244
Loa Loa (eye worm) RecQ helicase 0.0024 0.0144 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0142 0.0491
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0782 0.1728
Echinococcus multilocularis disco interacting protein 2 0.0038 0.0331 0.032
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0063 0.0643 0.1195
Brugia malayi Bromodomain containing protein 0.0075 0.08 0.3016
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0026 0.0169 0.0979
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0085 0.093 0.1169
Echinococcus multilocularis regulator of G protein signaling 3 0.0061 0.0627 0.0616
Brugia malayi Phosphoglycerate kinase 0.0085 0.093 0.3546
Leishmania major DNA polymerase kappa, putative 0.004 0.0354 0.0446
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0166 0.0177
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0166 0.0265
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0169 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0453 0.1571
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0031 0.0237 0.0298
Brugia malayi jmjC domain containing protein 0.002 0.0088 0.0113
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0603 0.0592
Schistosoma mansoni chromobox protein 0.0145 0.1708 0.1936
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0612 0.0769
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0142 0.0491
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0089 0.0078
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0964 0.3346
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0166 0.0155
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0269 0.0853
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0086 0.0108
Echinococcus granulosus regulator of G protein signaling 3 0.0061 0.0627 0.0702
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.022 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0438 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0612 0.0769
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0612 0.0769
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0049
Schistosoma mansoni jumonji domain containing protein 0.0158 0.1874 0.2126
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0213 0.0738
Plasmodium vivax JmjC domain containing protein 0.002 0.0088 0.0498
Schistosoma mansoni hypothetical protein 0.0021 0.01 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0217
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0142 0.013
Trichomonas vaginalis hypothetical protein 0.0024 0.0142 0.0491
Entamoeba histolytica hypothetical protein 0.0035 0.0286 0.2319
Loa Loa (eye worm) hypothetical protein 0.0037 0.0312 0.0549
Brugia malayi jmjC domain containing protein 0.0075 0.0808 0.305
Brugia malayi AF-10 protein 0.002 0.0091 0.0126
Plasmodium vivax SET domain protein, putative 0.003 0.0219 0.1978
Loa Loa (eye worm) hypothetical protein 0.0035 0.0291 0.0509
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0228 0.2078
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0088 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0142 0.0491

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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