Detailed information for compound 1228933

Basic information

Technical information
  • TDR Targets ID: 1228933
  • Name: (3Z)-3-[4-oxo-3-(oxolan-2-ylmethyl)-2-sulfany lidene-1,3-thiazolidin-5-ylidene]-1H-indol-2- one
  • MW: 346.424 | Formula: C16H14N2O3S2
  • H donors: 1 H acceptors: 2 LogP: 2.09 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1S/C(=C/2\C(=O)Nc3c2cccc3)/C(=O)N1CC1CCCO1
  • InChi: 1S/C16H14N2O3S2/c19-14-12(10-5-1-2-6-11(10)17-14)13-15(20)18(16(22)23-13)8-9-4-3-7-21-9/h1-2,5-6,9H,3-4,7-8H2,(H,17,19)/b13-12-
  • InChiKey: JXHKAFWUUUPKKJ-SEYXRHQNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-oxo-3-(oxolan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-1H-indol-2-one
  • (3Z)-3-[4-oxo-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-thiazolidin-5-ylidene]indolin-2-one
  • 3-[4-oxo-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-thiazolidin-5-ylidene]indolin-2-one
  • (3Z)-3-[4-oxo-3-(2-tetrahydrofuranylmethyl)-2-thioxo-5-thiazolidinylidene]-2-indolinone
  • 3-[4-oxo-3-(2-tetrahydrofuranylmethyl)-2-thioxo-5-thiazolidinylidene]-2-indolinone
  • (3Z)-3-[4-keto-3-(tetrahydrofurfuryl)-2-thioxo-thiazolidin-5-ylidene]oxindole
  • 3-[4-keto-3-(tetrahydrofurfuryl)-2-thioxo-thiazolidin-5-ylidene]oxindole
  • BIM-0035514.P001
  • MLS000108613
  • STOCK1S-28481
  • SMR000104566
  • Oprea1_253337
  • CBMicro_035567

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0668 0.597
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0395 0.4167
Echinococcus granulosus cpg binding protein 0.003 0.0218 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0171
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0201 0.0197
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1671 0.3158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0007 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0395 0.0391
Schistosoma mansoni hypothetical protein 0.0405 0.4175 0.4175
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0714 0.1278
Leishmania major GTP-binding protein, putative 0.0066 0.0597 0.526
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0095 0.0354
Schistosoma mansoni ran 0.0066 0.0597 0.0597
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0687 0.6161
Brugia malayi hypothetical protein 0.001 0.0007 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0114 0.0141
Echinococcus granulosus aminopeptidase N 0.0074 0.0681 0.0681
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0319 0.0319
Trypanosoma brucei unspecified product 0.0022 0.0131 0.0706
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0527 0.546 0.546
Echinococcus granulosus hypothetical protein 0.0027 0.0185 0.0185
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0036 0.0279 0.0279
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0687 0.0687
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0562 0.0562
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0175 0.1033
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0036 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0027 0.0185 0.0181
Schistosoma mansoni DNA polymerase eta 0.0022 0.0131 0.0131
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0016 0.0066 0.0066
Onchocerca volvulus 0.0064 0.0575 0.1093
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.107 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0175 0.1033
Loa Loa (eye worm) hypothetical protein 0.0042 0.0347 0.0343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0379 0.0379
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0114 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1421 0.1417
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0114 0.042
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0687 0.6161
Echinococcus multilocularis Smad4 0.001 0.0004 0.0004
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0356 0.0356
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.107 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0114 0.0141
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0131 0.0126
Entamoeba histolytica hypothetical protein 0.004 0.0319 0.3931
Trypanosoma brucei trypanothione reductase 0.0047 0.0395 0.332
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2599 0.4955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0114 0.0241
Trypanosoma brucei hypothetical protein 0.0111 0.107 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0687 0.0683
Entamoeba histolytica protein kinase rad3, putative 0.002 0.0114 0.0564
Brugia malayi Importin beta-1 subunit 0.009 0.0847 0.1849
Plasmodium falciparum glutathione reductase 0.0047 0.0395 0.4167
Onchocerca volvulus 0.0074 0.0681 0.1298
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0379 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Leishmania major DNA polymerase eta, putative 0.0022 0.0131 0.0587
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0681 0.6101
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.0279 0.0279
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0066 0.0597 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0395 0.0395
Schistosoma mansoni tar DNA-binding protein 0.007 0.0636 0.0636
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0095 0.0045
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.002 0.0114 0.0564
Schistosoma mansoni cpg binding protein 0.0028 0.0201 0.0201
Toxoplasma gondii thioredoxin reductase 0.0047 0.0395 0.4621
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Schistosoma mansoni ferritin light chain 0.0018 0.0095 0.0095
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0131 0.0277
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0072 0.0126
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0175 0.1033
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.008 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Schistosoma mansoni importin beta-1 0.009 0.0847 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Echinococcus multilocularis serine protein kinase ATM 0.0049 0.042 0.042
Brugia malayi glutathione reductase 0.0047 0.0395 0.0857
Echinococcus multilocularis ferritin 0.0018 0.0095 0.0095
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0279 0.0602
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0111 0.107 1
Plasmodium vivax importin-beta 2, putative 0.009 0.0847 1
Schistosoma mansoni apoferritin-2 0.0018 0.0095 0.0095
Brugia malayi hypothetical protein 0.004 0.0319 0.0689
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1767 0.3342
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.107 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0714 0.1302
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0131 0.0914
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0714 0.1302
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1671 0.3158
Brugia malayi beta-lactamase family protein 0.0077 0.0714 0.1557
Mycobacterium ulcerans hypothetical protein 0.0077 0.0714 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0494 0.58
Onchocerca volvulus 0.0077 0.0714 0.136
Entamoeba histolytica Ran family GTPase 0.0066 0.0597 0.8519
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.6428
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.0279 0.2071
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0131 0.0117
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0131 0.0131
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.2599 0.5695
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0023 0.0138 0.1567
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0026 0.0175 0.0171
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0171
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0036 0.0279 0.2071
Toxoplasma gondii aminopeptidase N protein 0.0026 0.0175 0.2005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0131 0.0117
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.071
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0036 0.0279 0.2071
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0131 0.0706
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0066 0.0597 0.6776
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.2051 0.3933
Giardia lamblia DINP protein human, muc B family 0.0022 0.0131 0.1117
Schistosoma mansoni ferritin 0.0018 0.0095 0.0095
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0074 0.0681 0.0681
Echinococcus multilocularis aminopeptidase N 0.0074 0.0681 0.0681
Loa Loa (eye worm) RNA binding protein 0.007 0.0636 0.0632
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0279 0.2071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0379 0.0379
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0131 0.0706
Trichomonas vaginalis esterase, putative 0.0077 0.0714 0.1302
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0279 0.2071
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0668 0.1214
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1671 0.3158
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.0279 0.2171
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0714 0.1278
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0007 0.0005
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0114 0.0114
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0356 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0687 0.0687
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0016 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0066 0.0047
Brugia malayi CXXC zinc finger family protein 0.0028 0.0201 0.0431
Trichomonas vaginalis hypothetical protein 0.0017 0.008 0.0075
Schistosoma mansoni tar DNA-binding protein 0.007 0.0636 0.0636
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0036 0.028 0.2079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0714 0.1278
Onchocerca volvulus 0.0077 0.0714 0.136
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0072 0.0778
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0379 0.0379
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0714 0.071
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0048 0.0407 0.3353
Echinococcus multilocularis translational activator gcn1 0.0017 0.008 0.008
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0687 0.1498
Leishmania major trypanothione reductase 0.0047 0.0395 0.3235
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0597 0.526
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1154 0.2154
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0074 0.0681 0.0681
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0575 0.6763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0138 0.0188
Brugia malayi TAR-binding protein 0.007 0.0636 0.1387
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0714 0.1302
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0714 0.0714
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0007 0.0005
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0131 0.0131
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0575 0.0575
Schistosoma mansoni dishevelled 0.001 0.0007 0.0007
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0668 0.1214
Schistosoma mansoni tar DNA-binding protein 0.007 0.0636 0.0636
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0279 0.2071
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0072 0.0148
Brugia malayi tumor suppressor. 0.0319 0.3261 0.7148
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0095 0.0354
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0026 0.0175 0.0175
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.0175 0.1331
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0072 0.5
Trichomonas vaginalis ran, putative 0.0066 0.0597 0.1077
Loa Loa (eye worm) hypothetical protein 0.002 0.0114 0.011
Entamoeba histolytica hypothetical protein 0.0073 0.0668 0.9686
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.071
Brugia malayi DIX domain containing protein 0.001 0.0007 0.0005
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.0175 0.1331
Loa Loa (eye worm) hypothetical protein 0.0023 0.0138 0.0134
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1028 0.1904
Echinococcus granulosus ferritin 0.0018 0.0095 0.0095
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0687 0.6161
Loa Loa (eye worm) glutathione reductase 0.0047 0.0395 0.0391
Brugia malayi Thioredoxin reductase 0.0047 0.0395 0.0857
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0048 0.0407 0.0407
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0575 0.0575
Leishmania major phosphatidylinositol kinase related protein, putative 0.0036 0.028 0.2079
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0714 0.6473
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.0175 0.0171
Echinococcus granulosus expressed protein 0.0018 0.0095 0.0095
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Loa Loa (eye worm) tumor suppressor 0.0319 0.3261 0.3258
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0636 0.1387
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0131 0.0131
Echinococcus granulosus smad 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.001 0.0007 0.0005
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0681 0.1485
Loa Loa (eye worm) hypothetical protein 0.0022 0.0131 0.0126
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.008 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.042 0.0734
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.008 0.0075
Schistosoma mansoni ferritin 0.0018 0.0095 0.0095
Leishmania major DNA polymerase kappa, putative 0.0022 0.0131 0.0587
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0714 0.1278
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.008 0.0075
Onchocerca volvulus 0.0074 0.0681 0.1298
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.107 1
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.0175 0.2005
Schistosoma mansoni tar DNA-binding protein 0.007 0.0636 0.0636
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.107 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.107 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0714 1
Brugia malayi beta-lactamase 0.0077 0.0714 0.1557
Echinococcus granulosus importin 5 0.0017 0.008 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0687 0.621
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0714 0.5844
Schistosoma mansoni regulator of G protein signaling 0.001 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.042 0.3486
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Onchocerca volvulus 0.0028 0.0201 0.0374
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.8374 0.8374
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0279 0.2071
Schistosoma mansoni Smad4 0.001 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0681 0.1485
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1028 0.1904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0072 0.0126
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0066 0.0597 0.7027
Schistosoma mansoni tar DNA-binding protein 0.007 0.0636 0.0636
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0066 0.0597 0.532
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0714 0.1278
Schistosoma mansoni ferritin 0.0018 0.0095 0.0095
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0175 0.1033
Schistosoma mansoni apoferritin-2 0.0018 0.0095 0.0095
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0036 0.0279 0.2071
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0095 0.0045
Schistosoma mansoni ferritin light chain 0.0018 0.0095 0.0095
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0131 0.0277
Brugia malayi FAT domain containing protein 0.0016 0.0066 0.0134
Echinococcus multilocularis transportin 1 0.0017 0.008 0.008
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0074 0.0681 0.0681
Schistosoma mansoni hypothetical protein 0.0527 0.546 0.546
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0036 0.0279 0.2071
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.107 1
Toxoplasma gondii FATC domain-containing protein 0.0049 0.042 0.4919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0347 0.2757
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1154 0.2154
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0036 0.0279 0.3277
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1671 0.3158
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.107 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0319 0.0319
Brugia malayi N-terminal motif family protein 0.0204 0.2051 0.4491
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0597 0.526
Schistosoma mansoni hypothetical protein 0.0958 1 1
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0095 1
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0007 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0126
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.008 0.087
Schistosoma mansoni smad1 5 8 and 0.001 0.0004 0.0004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0714 0.1278
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0131 0.0914
Brugia malayi beta-lactamase family protein 0.0077 0.0714 0.1557
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0185 0.0397
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.0571
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0279 0.2171
Brugia malayi hypothetical protein 0.0027 0.0185 0.0397
Schistosoma mansoni cpg binding protein 0.003 0.0218 0.0218
Schistosoma mansoni dep domain containing protein 0.001 0.0007 0.0007
Echinococcus multilocularis dna polymerase eta 0.0022 0.0131 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Loa Loa (eye worm) peptidase family M1 containing protein 0.0026 0.0175 0.0171
Echinococcus multilocularis protein quaking 0.0027 0.0185 0.0185
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.107 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0072 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.071
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0114 0.0114
Trypanosoma brucei calpain-like protein, putative 0.0111 0.107 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2599 0.4955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0714 0.1278
Brugia malayi hypothetical protein 0.0074 0.0681 0.1485
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2599 0.4955
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1767 0.3342
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0131 0.0587
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0126
Echinococcus granulosus dna polymerase kappa 0.0022 0.0131 0.0131
Trypanosoma brucei calpain, putative 0.0111 0.107 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0279 0.0602
Mycobacterium ulcerans beta-lactamase 0.0077 0.0714 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0175 0.1033
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0131 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0714 0.6428
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8686 0.8686
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8686 0.8686
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0575 0.0575
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0114 0.0114
Echinococcus multilocularis importin 5 0.0017 0.008 0.008
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0066 0.0597 0.0597
Plasmodium falciparum transportin 0.0017 0.008 0.0099
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0279 0.2071
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0544 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Echinococcus multilocularis expressed protein 0.0018 0.0095 0.0095
Loa Loa (eye worm) beta-lactamase 0.0077 0.0714 0.071
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0066 0.0597 0.6776
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.0175 0.2005
Entamoeba histolytica aminopeptidase, putative 0.0074 0.0681 0.9901
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0379 0.0375
Brugia malayi RNA, U transporter 1 0.0255 0.2591 0.5677
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.107 1
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0175 0.0375
Trichomonas vaginalis ferritin, putative 0.0018 0.0095 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0131 0.0587
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1028 0.1904
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2599 0.4955
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0036 0.0279 0.3277
Giardia lamblia GTOR 0.0036 0.0279 0.3938
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0681 0.1239
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0131 0.0587
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0072
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0072
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0066 0.0597 0.0593
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0007 0.0002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.4561 0.4558
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.0279 0.0279
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0714 0.0714
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0714 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0379 0.0379
Plasmodium falciparum importin beta, putative 0.009 0.0847 1
Loa Loa (eye worm) aminopeptidase N 0.0074 0.0681 0.0677
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0636 0.0632
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0004 0.0004
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0681 0.1239
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0279 0.0275
Echinococcus multilocularis tar DNA binding protein 0.007 0.0636 0.0636
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.042 0.0912
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0049 0.042 0.042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0714 0.0714
Echinococcus granulosus GTP binding nuclear protein Ran 0.0066 0.0597 0.0597
Onchocerca volvulus 0.0026 0.0175 0.0324
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.0279 0.2171
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1671 0.3203
Echinococcus multilocularis importin subunit beta 1 0.009 0.0847 0.0847
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0681 0.6101
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0847 0.7791
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0131 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0714 0.828
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0395 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Schistosoma mansoni hypothetical protein 0.0027 0.0185 0.0185
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1028 0.8812
Schistosoma mansoni cpg binding protein 0.003 0.0218 0.0218
Trichomonas vaginalis set domain proteins, putative 0.0503 0.5204 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0319 0.0319
Echinococcus granulosus importin subunit beta 1 0.009 0.0847 0.0847
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2599 0.4955
Mycobacterium tuberculosis Probable reductase 0.0107 0.1028 0.1904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0279 0.2171
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0027 0.0049
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0681 0.6101
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0004 0.0004
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.0175 0.0175
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0027 0.0049
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0681 0.615
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0175 0.1033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0131 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0114 0.0141
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0004 0.0004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0681 0.0681
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0681 0.9492
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.107 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.107 1
Schistosoma mansoni dishevelled 0.001 0.0007 0.0007
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0007 0.0007
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0687 0.0687
Onchocerca volvulus 0.0503 0.5204 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0061
Brugia malayi TATA binding protein associated factor 0.0026 0.0175 0.0375
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0131 0.0173
Echinococcus granulosus serine protein kinase ATM 0.0049 0.042 0.042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0131 0.0587
Schistosoma mansoni ferritin 0.0018 0.0095 0.0095
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0017 0.0028
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0847 0.7791
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0131 0.0587
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8686 0.8686
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0379 0.0379
Echinococcus granulosus geminin 0.0527 0.546 0.546
Brugia malayi Pre-SET motif family protein 0.0064 0.0575 0.1252
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0379 0.0379
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0007 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2599 0.4955
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0279 0.0275
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0072 0.0778
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0114 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0714 0.1302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0575 0.0575
Entamoeba histolytica hypothetical protein 0.004 0.0319 0.3931
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.0403
Leishmania major hypothetical protein, conserved 0.0017 0.008 0.0077
Loa Loa (eye worm) TAR-binding protein 0.007 0.0636 0.0632
Entamoeba histolytica hypothetical protein 0.004 0.0319 0.3931
Mycobacterium ulcerans lipase LipD 0.0077 0.0714 1
Plasmodium vivax glutathione reductase, putative 0.0047 0.0395 0.4167
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.008 0.0202
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.2599 0.2596
Trypanosoma brucei aminopeptidase, putative 0.0026 0.0175 0.1146
Trypanosoma cruzi Aminopeptidase M1, putative 0.0074 0.0681 0.6101
Echinococcus granulosus leukotriene A 4 hydrolase 0.0026 0.0175 0.0175
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0049 0.042 0.3568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0138 0.0188
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0958 1 1
Plasmodium vivax transportin, putative 0.0017 0.008 0.0099
Toxoplasma gondii HEAT repeat-containing protein 0.009 0.0847 1
Echinococcus granulosus tar DNA binding protein 0.007 0.0636 0.0636
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0131 0.0839
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1154 0.2154
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.0175 0.0175
Schistosoma mansoni smad1 5 8 and 0.001 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0077 0.0714 0.6428
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0048 0.0407 0.0407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0575 0.0575
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1671 0.3158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Brugia malayi RNA binding protein 0.007 0.0636 0.1387
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0072 0.006
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.071
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1671 0.3158
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0687 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0026 0.0175 0.0175
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0279 0.3239
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0114 0.0141
Mycobacterium leprae Probable lipase LipE 0.0077 0.0714 0.5844
Echinococcus multilocularis geminin 0.0527 0.546 0.546
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.4175 0.4175
Mycobacterium tuberculosis Conserved protein 0.0077 0.0714 0.1278
Loa Loa (eye worm) hypothetical protein 0.009 0.0847 0.0843
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0681 0.615
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1671 0.3158
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1028 0.1904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0681 0.6101
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0111 0.107 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0395 0.0643
Schistosoma mansoni ran 0.0066 0.0597 0.0597
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0681 0.615
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.0403
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0175 0.1607
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0095 1
Toxoplasma gondii ABC1 family protein 0.0077 0.0714 0.8414
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0007 0.0007
Leishmania major importin beta-1 subunit, putative 0.0073 0.0668 0.597
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.071
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0714 1
Echinococcus multilocularis cpg binding protein 0.003 0.0218 0.0218
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0175 0.1331
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0036 0.0279 0.2171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0379 0.0822
Brugia malayi kap beta 3 protein 0.0017 0.008 0.0165
Mycobacterium tuberculosis Conserved protein 0.0077 0.0714 0.1278
Echinococcus granulosus dnaJ subfamily B 0.0405 0.4175 0.4175
Plasmodium falciparum thioredoxin reductase 0.0047 0.0395 0.4167
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1421 0.1417
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0114 0.0141
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0018 0.0014
Brugia malayi Pre-SET motif family protein 0.0442 0.4561 1
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0131 0.0706
Echinococcus granulosus protein quaking 0.0027 0.0185 0.0185
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0575 0.0575
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0668 0.1214
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.5094 1
Entamoeba histolytica hypothetical protein 0.0049 0.042 0.5602
Echinococcus granulosus dna polymerase eta 0.0022 0.0131 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Echinococcus granulosus Smad4 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.004 0.0319 0.0319
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0395 0.3235
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0175 0.0259
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1154 1
Echinococcus multilocularis snurportin 1 0.0958 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1028 0.1904
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0131 0.0706
Echinococcus granulosus translational activator gcn1 0.0017 0.008 0.008
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0175 0.1033
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0175 0.1331
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.107 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0138 0.0782
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0007 0.0007
Onchocerca volvulus 0.0077 0.0714 0.136
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0714 0.1557
Mycobacterium tuberculosis Conserved protein 0.0077 0.0714 0.1278
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0714 0.1302
Loa Loa (eye worm) hypothetical protein 0.0204 0.2051 0.2047
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0131 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Schistosoma mansoni smad1 5 8 and 0.001 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.0144 0.1421 0.3109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0575 0.0575
Echinococcus granulosus transportin 1 0.0017 0.008 0.008
Schistosoma mansoni importin-beta 2 0.0017 0.008 0.008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0175 0.0175
Brugia malayi hypothetical protein 0.0026 0.0175 0.0375
Entamoeba histolytica hypothetical protein 0.004 0.0319 0.3931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0027 0.0185 0.0185
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0036 0.0279 0.0279
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0007 0.0007
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0007 0.0007
Schistosoma mansoni smad 0.001 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0018
Echinococcus multilocularis smad 0.001 0.0004 0.0004
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0007 0.0007
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0004 0.0004
Plasmodium vivax SET domain protein, putative 0.0064 0.0575 0.6489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0279 0.046
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0066 0.0597 0.1301

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) 66.7 uM PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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