Detailed information for compound 1242002

Basic information

Technical information
  • TDR Targets ID: 1242002
  • Name: [2-[(1,1-dioxothiolan-3-yl)-methylamino]-2-ox oethyl] 3,5-dimethyl-1-phenylpyrazole-4-carbo xylate
  • MW: 405.468 | Formula: C19H23N3O5S
  • H donors: 0 H acceptors: 5 LogP: 1.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C1CCS(=O)(=O)C1)C(=O)COC(=O)c1c(C)nn(c1C)c1ccccc1
  • InChi: 1S/C19H23N3O5S/c1-13-18(14(2)22(20-13)15-7-5-4-6-8-15)19(24)27-11-17(23)21(3)16-9-10-28(25,26)12-16/h4-8,16H,9-12H2,1-3H3
  • InChiKey: JZWBKZMWHUKZCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(1,1-dioxothiolan-3-yl)-methyl-amino]-2-oxo-ethyl] 3,5-dimethyl-1-phenyl-pyrazole-4-carboxylate
  • 3,5-dimethyl-1-phenyl-4-pyrazolecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)-methylamino]-2-oxoethyl] ester
  • 3,5-dimethyl-1-phenyl-pyrazole-4-carboxylic acid [2-[(1,1-diketothiolan-3-yl)-methyl-amino]-2-keto-ethyl] ester
  • T5248215
  • MLS001011077
  • SMR000353062

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii exonuclease III APE 0.0023 0.0078 0.1812
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0133 0.4822
Toxoplasma gondii thioredoxin reductase 0.0052 0.0265 0.6705
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Schistosoma mansoni lipoxygenase 0.0098 0.0555 0.2167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0326 0.1272
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0392 0.1528
Brugia malayi glutathione reductase 0.0052 0.0265 0.1413
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.0774 0.0735
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0049 0.159
Schistosoma mansoni hypothetical protein 0.0417 0.2563 1
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0083 0.2905
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0265 1
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0161
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0075 0.041 0.2183
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0049 0.0218
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.041 0.2183
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0078 0.0127
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.0774 0.0735
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0265 0.1413
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0049 0.155
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0107 0.3821
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0206 0.0196
Schistosoma mansoni cpg binding protein 0.0029 0.0119 0.0465
Trichomonas vaginalis esterase, putative 0.0043 0.0206 0.1055
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0392 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0078 1
Plasmodium falciparum flap endonuclease 1 0.0031 0.0133 0.4846
Schistosoma mansoni ap endonuclease 0.0023 0.0078 0.0304
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0392 0.0383
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0078 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0154 0.0906 0.482
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0392 0.1147
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0206 0.7664
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0041 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0031 0.012
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0219
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0049 0.023
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0265 0.0777
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0078 0.1027
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0133 0.3249
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0041 0.0032
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0133 0.0666
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0078 0.0414
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0206 0.1055
Leishmania major hypothetical protein, conserved 0.0043 0.0206 0.4692
Onchocerca volvulus 0.0043 0.0206 0.1699
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0031 0.012
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.001 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Brugia malayi SET domain containing protein 0.0012 0.0012 0.0066
Onchocerca volvulus 0.0029 0.0119 0.0985
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0392 0.1528
Echinococcus granulosus replication factor c subunit 1 0.0012 0.001 0.0028
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0206 0.0165
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0206 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Onchocerca volvulus 0.0058 0.0302 0.2495
Schistosoma mansoni cpg binding protein 0.0031 0.013 0.0506
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0206 0.0802
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.0442
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0008 0.0025
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0049 0.0008
Brugia malayi beta-lactamase family protein 0.0043 0.0206 0.1095
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0265 0.0434
Echinococcus granulosus nibrin 0.0012 0.001 0.0028
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0049 0.1066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0279 0.1088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0567
Plasmodium falciparum glutathione reductase 0.0052 0.0265 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0107 0.3791
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.0442
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0206 0.1059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.001 0.0047
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0049 0.159
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0392 0.0383
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6111 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0206 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0206 0.1055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0209 0.0341
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0133 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0041 0.1235
Echinococcus multilocularis nibrin 0.0012 0.001 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.1279 0.6793
Echinococcus granulosus chromobox protein 2 0.0012 0.0008 0.0025
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.001 0.0032
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0041 0.0219
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0078 0.2668
Schistosoma mansoni hypothetical protein 0.0346 0.212 0.8271
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Onchocerca volvulus 0.0031 0.0133 0.1096
Onchocerca volvulus 0.0012 0.0008 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.0956
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0049 0.155
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0329 0.1748
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0689 0.0651
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0012 0.0034
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0689 0.0651
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0041 0.0032
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0041 0.0032
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0219
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0049 0.023
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0041 0.0219
Brugia malayi Protein cec-1. 0.0012 0.0008 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0206 0.0337
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0019 0.01
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0275 0.1667 0.1632
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0041 0.0032
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0041 0.0032
Schistosoma mansoni hypothetical protein 0.0043 0.0209 0.0814
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0078 0.0228
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0206 0.1055
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0144
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Schistosoma mansoni chromobox protein 0.0012 0.0008 0.0033
Leishmania major trypanothione reductase 0.0052 0.0265 0.6396
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0008 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0206 0.7664
Echinococcus multilocularis chromobox protein 1 0.0071 0.0385 0.0631
Brugia malayi hypothetical protein 0.0012 0.001 0.0051
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1596 1 1
Onchocerca volvulus 0.0012 0.0012 0.0103
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0008 0.0045
Plasmodium falciparum thioredoxin reductase 0.0018 0.0049 0.159
Echinococcus multilocularis neuropeptide s receptor 0.0552 0.3416 0.559
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0155 0.0453
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0078 0.2702
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0041 0.0032
Echinococcus granulosus dnaJ subfamily B 0.0417 0.2563 0.7503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.005 0.0224
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0256 0.0751
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.001 0.0032
Brugia malayi Thioredoxin reductase 0.0052 0.0265 0.1413
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0019 0.0074
Echinococcus granulosus RUN 0.0024 0.0083 0.0243
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0206 0.1095
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.001 0.0037
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0049 0.004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0279 0.1485
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0041 0.0032
Brugia malayi hypothetical protein 0.0012 0.0008 0.0045
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.0689 0.068
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0008 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Echinococcus granulosus Chromo domain 0.0012 0.0008 0.0025
Onchocerca volvulus 0.0043 0.0206 0.1699
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0256 0.1326
Brugia malayi hypothetical protein 0.0286 0.1736 0.9237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0187 0.1547
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0279 0.1485
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0083 0.2905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0279 0.1088
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0997
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0685 1
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0329 0.175
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0078 0.5533
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0041 0.0032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0689 0.0651
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0041 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0114 0.0562
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Treponema pallidum NADH oxidase 0.0018 0.0049 0.581
Onchocerca volvulus Glucosylceramidase homolog 0.0202 0.121 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0012 0.0048
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0049 0.0262
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0049 0.159
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0041 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0107 0.3791
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0049 0.159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Mycobacterium tuberculosis Conserved protein 0.0043 0.0206 0.0165
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Schistosoma mansoni hypothetical protein 0.0346 0.212 0.8271
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.0956
Schistosoma mansoni flap endonuclease-1 0.0028 0.0114 0.0444
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0392 0.0352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.0104
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0206 0.0602
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0256 0.042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0685 0.112
Schistosoma mansoni loxhd1 0.0024 0.0083 0.0324
Loa Loa (eye worm) hypothetical protein 0.0286 0.1736 0.9237
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0078 0.0068
Brugia malayi CXXC zinc finger family protein 0.0029 0.0119 0.0634
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0083 0.0243
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1736 0.5081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.063 0.3354
Echinococcus granulosus Chromobox protein 3 0.0012 0.0008 0.0025
Schistosoma mansoni topbp1 0.0012 0.001 0.0037
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0041 0.0121
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0008 0.0045
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0041 0.0032
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0696 0.2716
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Brugia malayi hypothetical protein 0.0024 0.0083 0.0442
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.0774 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.1279 0.6793
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0049 0.004
Loa Loa (eye worm) helicase 0.0012 0.0008 0.0045
Loa Loa (eye worm) transcription factor SMAD2 0.0143 0.0834 0.4436
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0107 0.3791
Brugia malayi hypothetical protein 0.0012 0.001 0.0051
Brugia malayi chromobox protein homolog 3 0.004 0.0187 0.0997
Mycobacterium ulcerans lipase LipD 0.0043 0.0206 0.0196
Mycobacterium leprae putative cytochrome p450 0.0017 0.0041 0.0032
Echinococcus granulosus chromobox protein 1 0.0071 0.0385 0.1128
Onchocerca volvulus 0.0043 0.0206 0.1699
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0133 0.2618
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0083 0.0442
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0083 0.0243
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.0823
Brugia malayi hypothetical protein 0.0043 0.0209 0.111
Echinococcus multilocularis expressed conserved protein 0.0112 0.0639 0.1046
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0041 0.0032
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0049 0.155
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0008 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0209 0.0814
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.001 0.0051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0206 0.0165
Loa Loa (eye worm) hypothetical protein 0.011 0.063 0.3354
Mycobacterium ulcerans transcriptional regulator 0.1596 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0041 0.0032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0141 0.0823 0.2408
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0078 0.2702
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0107 0.2562
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.063 0.3354
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0083 0.0243
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0078 0.1046
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0008 0.0033
Echinococcus granulosus geminin 0.0346 0.212 0.6205
Echinococcus multilocularis cpg binding protein 0.0031 0.013 0.0212
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0078 0.2668
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0206 0.1055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.005 0.0224
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0155 0.0253
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0206 0.0165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Plasmodium falciparum glutathione reductase 0.0018 0.0049 0.159
Echinococcus multilocularis neuropeptide receptor A26 0.0552 0.3416 0.559
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.001 0.0006
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0008 0.0014
Schistosoma mansoni chromobox protein 0.0071 0.0385 0.1504
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0133 0.4822
Schistosoma mansoni patched 1 0.0051 0.0256 0.1
Echinococcus multilocularis geminin 0.0346 0.212 0.3469
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0049 0.581
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0302 0.1607
Loa Loa (eye worm) MH2 domain-containing protein 0.0143 0.0834 0.4436
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0107 0.3821
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0284 0.7196
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0279 0.0457
Mycobacterium tuberculosis Conserved protein 0.0043 0.0206 0.0165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0689 0.0651
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.0774 0.0765
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0008 0.0045
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0083 0.0136
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0041 0.1235
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0689 0.0651
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0049 0.004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0078 0.0037
Loa Loa (eye worm) cytochrome P450 0.0017 0.0041 0.0219
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0049 0.1066
Plasmodium vivax glutathione reductase, putative 0.0052 0.0265 1
Brugia malayi CHE-14 protein 0.0051 0.0256 0.1365
Echinococcus multilocularis protein dispatched 1 0.0058 0.0302 0.0494
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0046
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0206 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Brugia malayi hypothetical protein 0.0018 0.0046 0.0243
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0078 0.0371
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0385 0.2015
Brugia malayi CHD4 protein 0.0013 0.0019 0.0101
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0385 0.2051
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.001 0.0047
Echinococcus multilocularis Chromo domain 0.0012 0.0008 0.0014
Brugia malayi DKFZp564C0469 protein 0.0012 0.001 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Brugia malayi beta-lactamase family protein 0.0043 0.0206 0.1095
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1596 1 1
Onchocerca volvulus 0.0024 0.0083 0.0686
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0041 0.0032
Schistosoma mansoni hypothetical protein 0.0024 0.0083 0.0324
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0083 0.0136
Mycobacterium tuberculosis Probable reductase 0.012 0.0689 0.0651
Schistosoma mansoni lipoxygenase 0.0141 0.0823 0.3209
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0041 0.1235
Schistosoma mansoni rab6-interacting 0.0024 0.0083 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Echinococcus multilocularis RUN 0.0024 0.0083 0.0136
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0041 0.0219
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0078 0.2668
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0133 0.1842
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0155 0.0823
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0685 0.2004
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0049 0.155
Onchocerca volvulus 0.0012 0.001 0.0079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0049 0.155
Brugia malayi hypothetical protein 0.0154 0.0906 0.482
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.2563 0.4194
Schistosoma mansoni chromobox protein 0.0012 0.0008 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0279 0.0817
Schistosoma mansoni chromobox protein 0.0071 0.0385 0.1504
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0209 0.0611
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0385 0.2015
Trypanosoma brucei trypanothione reductase 0.0052 0.0265 1
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0219
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.023
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.001 0.0006
Brugia malayi topoisomerase 0.0012 0.001 0.0051
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0019 0.01
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0685 0.3643
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.001 0.0016
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0041 0.0032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0012 0.0019
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0041 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0206 0.7675
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0041 0.1235
Brugia malayi Heterochromatin protein 1 0.0071 0.0385 0.2051
Echinococcus multilocularis GPCR, family 2 0.0035 0.0155 0.0253
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0019 0.0101
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0041 0.0032
Brugia malayi MH2 domain containing protein 0.0143 0.0834 0.4436
Plasmodium falciparum thioredoxin reductase 0.0052 0.0265 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0041 0.0032
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0206 0.0165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0206 0.1095
Onchocerca volvulus 0.0012 0.0008 0.0069
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0265 1
Schistosoma mansoni hypothetical protein 0.0075 0.041 0.16
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0155 0.0823
Mycobacterium ulcerans TetR family transcriptional regulator 0.1596 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0041 0.1235
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0141 0.0823 0.1346
Mycobacterium leprae Probable lipase LipE 0.0043 0.0206 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0256 0.0751
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0041 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0107 0.3821
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0133 0.0218
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0041 0.1235
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0706
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0206 0.0196
Echinococcus multilocularis protein patched 0.0051 0.0256 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Brugia malayi hypothetical protein 0.0027 0.0107 0.0567
Schistosoma mansoni hypothetical protein 0.0058 0.0302 0.1178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0279 0.1088
Schistosoma mansoni polycystin 1-related 0.0024 0.0083 0.0324
Leishmania major hypothetical protein, conserved 0.0027 0.0107 0.1866
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0206 0.7664
Schistosoma mansoni survival motor neuron protein 0.0058 0.0302 0.1178
Onchocerca volvulus 0.0024 0.0083 0.0686
Toxoplasma gondii ABC1 family protein 0.0043 0.0206 0.5146
Echinococcus granulosus flap endonuclease 1 0.0031 0.0133 0.0389
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0081
Schistosoma mansoni rab6-interacting 0.0024 0.0083 0.0324
Entamoeba histolytica hypothetical protein 0.0012 0.001 0.0018
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0049 0.0218
Loa Loa (eye worm) glutathione reductase 0.0052 0.0265 0.1413
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0049 0.155
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0078 0.0371
Loa Loa (eye worm) hypothetical protein 0.0051 0.0256 0.1365
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1736 0.284
Brugia malayi Doublecortin family protein 0.0024 0.0083 0.0442
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Brugia malayi hypothetical protein 0.0024 0.0083 0.0442
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0155 0.0253
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0192
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0392 0.0641
Onchocerca volvulus 0.0154 0.0906 0.7483
Echinococcus granulosus neuropeptide s receptor 0.0552 0.3416 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.001 0.0006
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0133 0.4846
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0031
Mycobacterium ulcerans hypothetical protein 0.0043 0.0206 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0279 0.0817
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.001 0.0051
Mycobacterium ulcerans beta-lactamase 0.0043 0.0206 0.0196
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0041 0.1235
Schistosoma mansoni cpg binding protein 0.0031 0.013 0.0506
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Schistosoma mansoni DNA ligase IV 0.0012 0.001 0.0037
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0206 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0114 0.0562
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0155 0.0823
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0008 0.0045
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0206 0.0165
Loa Loa (eye worm) hypothetical protein 0.0119 0.0685 0.3643
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0308 0.1879 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0041 0.0032
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0049 0.581
Echinococcus granulosus chromobox protein 1 0.0071 0.0385 0.1128
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Echinococcus granulosus GPCR family 2 0.0035 0.0155 0.0453
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0049 1
Brugia malayi Flap endonuclease-1 0.0031 0.0133 0.0708
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0119 0.0634
Echinococcus granulosus cpg binding protein 0.0031 0.013 0.038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.063 0.3354
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Echinococcus multilocularis chromobox protein 2 0.0012 0.0008 0.0014
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1006 0.2946
Echinococcus granulosus expressed conserved protein 0.0112 0.0639 0.187
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0206 0.1055
Brugia malayi cytochrome P450 0.0017 0.0041 0.0219
Schistosoma mansoni cytochrome P450 0.0017 0.0041 0.0161
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0392 1
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Echinococcus granulosus neuropeptide receptor A26 0.0552 0.3416 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0392 0.0383
Echinococcus multilocularis chromobox protein 1 0.0071 0.0385 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Brugia malayi beta-lactamase 0.0043 0.0206 0.1095
Brugia malayi Cytochrome P450 family protein 0.0062 0.0329 0.1748
Loa Loa (eye worm) beta-lactamase 0.0043 0.0206 0.1095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0049 0.3215
Schistosoma mansoni topbp1 0.0012 0.001 0.0037
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0256 0.1365
Echinococcus multilocularis 0.0017 0.0041 0.0067
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0041 0.0856
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0041 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0279 0.0457
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0308 0.1879 1
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0078 0.0414
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0206 0.1706
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0049 0.155
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0133 0.0708
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0155 0.0453
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1006 0.1647
Schistosoma mansoni ap endonuclease 0.0023 0.0078 0.0304
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0206 0.0802
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0206 0.1059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0265 0.0225

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0562 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1458 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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