Detailed information for compound 1243299

Basic information

Technical information
  • TDR Targets ID: 1243299
  • Name: N-(1,3-benzodioxol-5-ylmethyl)-4-(3,4-dihydro -1H-isoquinolin-2-ylmethyl)benzamide
  • MW: 400.47 | Formula: C25H24N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)CN1CCc2c(C1)cccc2)NCc1ccc2c(c1)OCO2
  • InChi: 1S/C25H24N2O3/c28-25(26-14-19-7-10-23-24(13-19)30-17-29-23)21-8-5-18(6-9-21)15-27-12-11-20-3-1-2-4-22(20)16-27/h1-10,13H,11-12,14-17H2,(H,26,28)
  • InChiKey: ZOWNJHJCACTBET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-Benzo[1,3]dioxol-5-ylmethyl-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-benzamide
  • SMR000120506
  • STK129709
  • BAS 07782784
  • MLS000527932

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog Get druggable targets OG5_129328 All targets in OG5_129328
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0048 0.0115
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0029 0.0029
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.0052 0.6153
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0795
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0037 0.0037
Brugia malayi protein C24B5.3 0.0013 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0419 0.0604 1
Brugia malayi Smad1 0.0017 0.0009 0.0009
Schistosoma mansoni cpg binding protein 0.0031 0.0029 0.0029
Brugia malayi hypothetical protein 0.0075 0.0095 0.0095
Trichomonas vaginalis esterase, putative 0.0039 0.0042 0.0434
Echinococcus granulosus intermediate filament protein 0.0029 0.0027 0.0027
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0029 0.0296
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.0052 0.2073
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0095 0.0095
Leishmania major hypothetical protein, conserved 0.0025 0.0021 0.3738
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0029 0.112
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0009 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0052 0.2071
Echinococcus granulosus transcription factor eb 0.0109 0.0145 0.0145
Chlamydia trachomatis replicative DNA helicase 0.0419 0.0604 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0042 0.4818
Echinococcus granulosus Smad4 0.0017 0.0009 0.0009
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0052 1
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Echinococcus granulosus lamin 0.0029 0.0027 0.0027
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0027 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0033 0.0343
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0026 0.0026
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0109 0.0144 0.0144
Echinococcus granulosus smad 0.0017 0.0009 0.0009
Brugia malayi hypothetical protein 0.0133 0.018 0.018
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0036 0.0037 0.6922
Brugia malayi Patched related family protein 4 0.0013 0.0002 0.0002
Plasmodium vivax multidomain scavenger receptor, putative 0.0045 0.0051 0.2007
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0042 0.0042
Onchocerca volvulus 0.0039 0.0042 0.2304
Schistosoma mansoni peroxidasin 0.0029 0.0026 0.0026
Echinococcus multilocularis lamin 0.0029 0.0027 0.0027
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.003
Echinococcus multilocularis Niemann Pick C1 protein 0.0295 0.042 0.042
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0046 0.049
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Onchocerca volvulus Protein patched homolog 0.0013 0.0002 0.0126
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0042 0.0063
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.027 0.0384 0.0384
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.0595 0.0595
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0075 0.0095 0.104
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0216 0.0216
Echinococcus granulosus dnaJ subfamily B 0.0413 0.0595 0.0595
Echinococcus multilocularis protein dispatched 1 0.0101 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0078 0.0099 0.0099
Schistosoma mansoni rab6-interacting 0.0045 0.0051 0.0051
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0067 0.0083 0.0902
Brugia malayi beta-lactamase family protein 0.0039 0.0042 0.0042
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0021 0.0795
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0029 0.0029
Schistosoma mansoni smad1 5 8 and 0.0017 0.0009 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0046 0.049
Schistosoma mansoni smad 0.0017 0.0009 0.0009
Onchocerca volvulus 0.0013 0.0002 0.0126
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.0017 0.0009 0.0009
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0052 0.0555
Leishmania major heat shock protein, putative 0.0031 0.0029 0.5328
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0048 0.0507
Loa Loa (eye worm) endoplasmin 0.0046 0.0052 0.0052
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0007 0.0212
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0042 0.0042
Schistosoma mansoni intermediate filament proteins 0.0029 0.0027 0.0027
Echinococcus granulosus neuropeptide s receptor 0.0558 0.0809 0.0809
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0048 0.0507
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0042 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0078 0.0078
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.088
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0001 0.0001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0542
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0206 0.0289 0.3224
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.021 0.021
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0042 0.4916
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Echinococcus multilocularis RUN 0.0045 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Echinococcus multilocularis Niemann Pick C1 protein 0.0206 0.0289 0.0289
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0042 0.0434
Loa Loa (eye worm) Smad1 0.0017 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0078 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0042 0.0434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0075 0.0075
Schistosoma mansoni lipoxygenase 0.027 0.0384 0.0384
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0037 0.0037
Echinococcus granulosus muscleblind protein 0.0313 0.0447 0.0447
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0078 0.0078
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0212
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Onchocerca volvulus 0.0039 0.0042 0.2304
Schistosoma mansoni endoplasmin 0.0046 0.0052 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Echinococcus multilocularis Smad4 0.0017 0.0009 0.0009
Echinococcus granulosus microtubule associated protein 2 0.0749 0.1091 0.1091
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0083 0.0902
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Echinococcus granulosus cpg binding protein 0.0031 0.0029 0.0029
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Brugia malayi intermediate filament protein 0.0029 0.0027 0.0027
Brugia malayi MH1 domain containing protein 0.0017 0.0009 0.0009
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Echinococcus multilocularis GPCR, family 2 0.0036 0.0037 0.0037
Onchocerca volvulus 0.0029 0.0026 0.144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0051 0.0051
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0037 0.4259
Onchocerca volvulus Peroxidase homolog 0.0029 0.0026 0.144
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Brugia malayi hypothetical protein 0.0031 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0036 0.0037 0.0037
Brugia malayi protein C24B5.3 0.0013 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0355 0.0509 0.0509
Echinococcus granulosus caspase 2 0.0031 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.0042 0.0042
Brugia malayi hypothetical protein 0.0016 0.0008 0.0008
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0052 0.6153
Loa Loa (eye worm) RNA binding protein 0.0064 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi CHE-14 protein 0.0089 0.0115 0.0115
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0052 0.6153
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0042 0.4818
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0299 0.0426 0.0773
Schistosoma mansoni hypothetical protein 0.0413 0.0595 0.0595
Mycobacterium tuberculosis Conserved protein 0.0039 0.0042 0.0063
Echinococcus multilocularis Polycystic kidney disease protein 0.0045 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0036 0.0037 0.0037
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0042 0.0063
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0419 0.0604 0.3176
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Schistosoma mansoni hypothetical protein 0.6775 1 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.03 0.03
Echinococcus multilocularis transcription factor eb 0.0109 0.0145 0.0145
Brugia malayi MH1 domain containing protein 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0013 0.0002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0003 0.0003
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0051
Schistosoma mansoni cpg binding protein 0.0031 0.0029 0.0029
Brugia malayi Peroxidasin 0.0029 0.0026 0.0026
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0117 0.0157 0.0652
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0004
Echinococcus granulosus peroxidasin 0.0029 0.0026 0.0026
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0052 0.0052
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0109 0.0145 0.0145
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0007 0.0007
Echinococcus multilocularis cpg binding protein 0.0031 0.0029 0.0029
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0007 0.0212
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0026 0.0026
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0007
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi Niemann-Pick C1 protein precursor 0.0206 0.0289 0.0289
Echinococcus multilocularis microtubule associated protein 2 0.0749 0.1091 0.1091
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0009 0.0009
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0029 0.3278
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0027 0.0027
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3376 0.4974 0.9175
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi Hsp90 protein 0.0031 0.0029 0.0029
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0153 0.0153
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0021
Brugia malayi Myosin head containing protein 0.0013 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Brugia malayi beta-lactamase 0.0039 0.0042 0.0042
Leishmania major hypothetical protein, conserved 0.0039 0.0042 0.7831
Brugia malayi hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis expressed conserved protein 0.0194 0.027 0.027
Echinococcus granulosus heat shock protein 90 0.0046 0.0052 0.0052
Loa Loa (eye worm) heat shock protein 90 0.0046 0.0052 0.0052
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0083 0.0902
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0009 0.0009
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.03 0.03
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0052 0.2071
Echinococcus granulosus arachidonate 5 lipoxygenase 0.027 0.0384 0.0384
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.0353 0.0638
Onchocerca volvulus 0.0013 0.0002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0036 0.0037 0.0037
Brugia malayi RNA binding protein 0.0064 0.0078 0.0078
Echinococcus granulosus sterol regulatory element binding protein 0.0089 0.0115 0.0115
Echinococcus granulosus endoplasmin 0.0043 0.0048 0.0048
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0078 0.0078
Echinococcus granulosus expressed conserved protein 0.0194 0.027 0.027
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Loa Loa (eye worm) blistered cuticle protein 3 0.0029 0.0026 0.0026
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0612 0.0889 1
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.0052 1
Onchocerca volvulus 0.0013 0.0002 0.0126
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0009 0.0009
Brugia malayi heat shock protein 90 0.0046 0.0052 0.0052
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0029 0.1622
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0043 0.0048 0.0036
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0052 0.6153
Giardia lamblia Grp94/Hsp90 0.0043 0.0048 0.0507
Loa Loa (eye worm) hypothetical protein 0.0114 0.0153 0.0153
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0002
Schistosoma mansoni heat shock protein 0.0046 0.0052 0.0052
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Echinococcus multilocularis musashi 0.0029 0.0027 0.0027
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Brugia malayi Patched protein homolog 1 0.0013 0.0002 0.0002
Brugia malayi Doublecortin family protein 0.0045 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Schistosoma mansoni heat shock protein 0.0031 0.0029 0.0029
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Echinococcus granulosus heat shock protein 0.0046 0.0052 0.0052
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0021 0.3738
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0029 0.0027 0.0027
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0026 0.0026
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0009 0.0009
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0003 0.0032
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0052 0.0555
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.0144 0.0144
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0027 0.0027
Schistosoma mansoni patched 1 0.0089 0.0115 0.0115
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0002
Trypanosoma cruzi hypothetical protein 0.0067 0.0083 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Brugia malayi Endoplasmin precursor 0.0046 0.0052 0.0052
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0048 0.9145
Onchocerca volvulus 0.0013 0.0002 0.0126
Trichomonas vaginalis Sentrin-specific protease, putative 0.0067 0.0083 0.0902
Echinococcus granulosus heat shock protein 90 0.004 0.0042 0.0042
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0052 0.0554
Entamoeba histolytica hypothetical protein 0.0075 0.0095 0.104
Schistosoma mansoni lamin 0.0029 0.0027 0.0027
Echinococcus granulosus sentrin specific protease 8 0.0067 0.0083 0.0083
Plasmodium vivax sentrin-specific protease 1, putative 0.0013 0.0003 0.0032
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0299 0.0426 0.6839
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Onchocerca volvulus 0.0045 0.0051 0.2807
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni lamin 0.0029 0.0027 0.0027
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0039 0.0042 0.0063
Loa Loa (eye worm) hypothetical protein 0.0313 0.0447 0.0447
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.003 0.166
Echinococcus multilocularis sentrin specific protease 7 0.0013 0.0003 0.0003
Treponema pallidum recombinase A 0.0117 0.0157 0.1295
Brugia malayi Patched related family protein 10 0.0013 0.0002 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0037 0.0037
Echinococcus multilocularis sentrin specific protease 8 0.0067 0.0083 0.0083
Onchocerca volvulus Protein patched homolog 0.0013 0.0002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis protein patched 0.0089 0.0115 0.0115
Brugia malayi beta-lactamase family protein 0.0039 0.0042 0.0042
Toxoplasma gondii heat shock protein HSP90 0.0046 0.0052 0.2073
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0033 0.0343
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus tar DNA binding protein 0.0064 0.0078 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Brugia malayi hypothetical protein 0.0045 0.0051 0.0051
Schistosoma mansoni peroxidasin 0.0029 0.0026 0.0026
Schistosoma mansoni Smad4 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0133 0.018 0.018
Echinococcus multilocularis smad 0.0017 0.0009 0.0009
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.6775 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0042 0.0434
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Plasmodium falciparum heat shock protein 90 0.0046 0.0052 0.2073
Plasmodium falciparum endoplasmin, putative 0.0034 0.0033 0.1294
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0024 0.0231
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Onchocerca volvulus 0.0029 0.0027 0.1479
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0003 0.0003
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0007 0.088
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0209 0.0293 0.0293
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.0354 0.0354
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0078 0.0078
Onchocerca volvulus Huntingtin homolog 0.0133 0.018 1
Echinococcus multilocularis muscleblind protein 0.0313 0.0447 0.0447
Schistosoma mansoni hypothetical protein 0.0075 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0052 0.0554
Echinococcus multilocularis caspase 2 0.0031 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0075 0.0095 0.104
Trichomonas vaginalis heat shock protein, putative 0.004 0.0042 0.0443
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0037 0.0037
Loa Loa (eye worm) twinkle helicase 0.012 0.0161 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0078 0.0078
Schistosoma mansoni endoplasmin 0.0046 0.0052 0.0052
Schistosoma mansoni smad1 5 8 and 0.0017 0.0009 0.0009
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.003 0.003
Schistosoma mansoni microtubule-associated protein tau 0.0749 0.1091 0.1091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0042 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0216 0.0216
Plasmodium vivax heat shock protein, putative 0.0175 0.0243 1
Schistosoma mansoni hypothetical protein 0.0036 0.0037 0.0037
Onchocerca volvulus Huntingtin homolog 0.0133 0.018 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0612 0.0889 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0085 0.011 0.011
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0029 0.112
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0067 0.0083 0.0083
Trypanosoma cruzi DNA repair protein, putative 0.0036 0.0037 0.4259
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.018 0.018
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0089 0.0115 0.0115
Loa Loa (eye worm) beta-lactamase 0.0039 0.0042 0.0042
Echinococcus multilocularis heat shock protein 0.0046 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Schistosoma mansoni hypothetical protein 0.0036 0.0037 0.0037
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Schistosoma mansoni rab6-interacting 0.0045 0.0051 0.0051
Schistosoma mansoni polycystin 1-related 0.0045 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Mycobacterium tuberculosis Conserved protein 0.0039 0.0042 0.0063
Schistosoma mansoni lipoxygenase 0.0189 0.0263 0.0263
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.0809 0.0809
Brugia malayi TAR-binding protein 0.0064 0.0078 0.0078
Echinococcus granulosus sentrin specific protease 1 0.0013 0.0003 0.0003
Echinococcus multilocularis peroxidasin 0.0029 0.0026 0.0026
Echinococcus multilocularis sentrin specific protease 1 0.0013 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Brugia malayi hypothetical protein 0.0013 0.0002 0.0002
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0052 0.6153
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0051
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0052 0.0555
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.003
Plasmodium vivax heat shock protein 86, putative 0.0046 0.0052 0.2073
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Onchocerca volvulus Dual oxidase homolog 0.0029 0.0026 0.144
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.23
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0117 0.0157 0.1959
Echinococcus granulosus Niemann Pick C1 protein 0.0295 0.042 0.042
Brugia malayi Blistered cuticle protein 3 0.0029 0.0026 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0042 0.0434
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0419 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0004
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0017 0.0009 0.0009
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0021 0.0795
Treponema pallidum replicative DNA helicase (dnaB) 0.0419 0.0604 0.6607
Schistosoma mansoni smad1 5 8 and 0.0017 0.0009 0.0009
Brugia malayi hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0009 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0031 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0099 0.0099
Brugia malayi CXXC zinc finger family protein 0.0029 0.0027 0.0027
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0067 0.0083 0.0083
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.6775 1 1
Loa Loa (eye worm) doublecortin family protein 0.0045 0.0051 0.0051
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0007
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3678 0.5421 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.003 0.003
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0026 0.0026
Brugia malayi hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0009 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0037 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0108 0.0144 0.0144
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0026 0.144
Brugia malayi hypothetical protein 0.0029 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.025 0.0354 0.0354
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0003 0.0003
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.0809 0.0809
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.088
Loa Loa (eye worm) hypothetical protein 0.0206 0.0289 0.0289
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Onchocerca volvulus Peroxidase homolog 0.0029 0.0026 0.144
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0026 0.144
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0027 0.0027
Onchocerca volvulus 0.0031 0.003 0.166
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0042 0.0063
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0042 0.0063
Onchocerca volvulus 0.0029 0.0026 0.144
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Plasmodium vivax sentrin-specific protease 2, putative 0.0013 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi Patched family protein 0.0013 0.0002 0.0002
Plasmodium vivax endoplasmin, putative 0.0046 0.0052 0.2073
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0051 0.0051
Echinococcus granulosus sentrin specific protease 7 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Onchocerca volvulus 0.0029 0.0026 0.144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0206 0.0289 0.0289
Echinococcus granulosus lamin dm0 0.0029 0.0027 0.0027
Mycobacterium ulcerans recombinase A 0.0117 0.0157 0.2052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0085 0.011 0.011
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0095 0.0095
Schistosoma mansoni loxhd1 0.0045 0.0051 0.0051
Onchocerca volvulus 0.0013 0.0002 0.0126
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0003 0.0003
Schistosoma mansoni Replicative DNA helicase 0.0419 0.0604 0.0604
Brugia malayi hypothetical protein 0.0025 0.0021 0.0021
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0029 0.5328
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis muscleblind protein 1 0.0313 0.0447 0.0447
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.23
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0795
Toxoplasma gondii ABC1 family protein 0.0039 0.0042 0.1631
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus RUN 0.0045 0.0051 0.0051
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0026 0.0026
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Brugia malayi hypothetical protein 0.0045 0.0051 0.0051
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.0042 0.0443
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0042 0.0063
Toxoplasma gondii Hsp90 domain-containing protein 0.0175 0.0243 1
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0012 0.1174
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0299 0.0426 0.2172
Schistosoma mansoni hypothetical protein 0.6775 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0095 0.0095
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0115 0.126
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0029 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0042 0.7831
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Echinococcus multilocularis sterol regulatory element binding protein 0.0089 0.0115 0.0115
Treponema pallidum fructose-bisphosphate aldolase 0.0612 0.0889 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0042 0.0434
Onchocerca volvulus 0.0013 0.0002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.0042 0.4916
Brugia malayi Muscleblind-like protein 0.0313 0.0447 0.0447
Plasmodium falciparum heat shock protein 90, putative 0.0175 0.0243 1
Schistosoma mansoni hypothetical protein 0.0355 0.0509 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.0292 0.3258
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0046 0.1835
Echinococcus multilocularis heat shock protein 90 0.0046 0.0052 0.0052
Echinococcus granulosus GPCR family 2 0.0036 0.0037 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0071 0.2842
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0212
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0048 0.0075
Schistosoma mansoni hypothetical protein 0.0085 0.011 0.011
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0051 0.2007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0052 0.2071
Echinococcus granulosus geminin 0.0355 0.0509 0.0509
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0042 0.1631
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0042 0.0042
Schistosoma mansoni heat shock protein 0.0046 0.0052 0.0052
Brugia malayi Patched related family protein 12 0.0013 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0075 0.0095 0.104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi Cell death protein 3 precursor 0.0031 0.003 0.003
Echinococcus granulosus Protein patched homolog 1 0.0089 0.0115 0.0115
Echinococcus multilocularis geminin 0.0355 0.0509 0.0509
Loa Loa (eye worm) Ulp1 protease 0.0067 0.0083 0.0083
Onchocerca volvulus 0.0029 0.0027 0.15
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0153 0.0153
Mycobacterium leprae Conserved hypothetical protein 0.1236 0.1812 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0612 0.0889 1
Chlamydia trachomatis recombinase RecA 0.0117 0.0157 0.2561
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0542
Trypanosoma brucei heat shock protein, putative 0.0046 0.0052 1
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0216 0.0216
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0003 0.0032
Giardia lamblia Fructose-bisphosphate aldolase 0.0612 0.0889 1
Schistosoma mansoni hypothetical protein 0.0085 0.011 0.011
Onchocerca volvulus 0.0039 0.0042 0.2304
Echinococcus multilocularis heat shock protein 90 0.004 0.0042 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0037 0.0037
Onchocerca volvulus 0.0029 0.0027 0.15
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0078 0.0078
Onchocerca volvulus Chorion peroxidase homolog 0.0029 0.0026 0.144
Schistosoma mansoni hypothetical protein 0.0045 0.0051 0.0051
Loa Loa (eye worm) acetyltransferase 0.0157 0.0216 0.0216
Onchocerca volvulus 0.0013 0.0003 0.0169
Leishmania major heat shock protein 83-1 0.0046 0.0052 1
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0024 0.0884
Echinococcus multilocularis lamin dm0 0.0029 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.6775 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0313 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1699 0.2496 0.2496
Onchocerca volvulus 0.0045 0.0051 0.2807
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.0809 0.0809
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0045 0.0051 0.0051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0083 0.0902
Plasmodium falciparum sentrin-specific protease 1 0.0013 0.0003 0.0032
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0052 0.0555
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0042 0.0042
Echinococcus multilocularis endoplasmin 0.0043 0.0048 0.0048

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 7.5 uM PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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