Detailed information for compound 1254557

Basic information

Technical information
  • TDR Targets ID: 1254557
  • Name: 1-[4-(phenoxy)benzoyl]piperidine-4-carboxamid e
  • MW: 324.374 | Formula: C19H20N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)Oc1ccccc1)N1CCC(CC1)C(=O)N
  • InChi: 1S/C19H20N2O3/c20-18(22)14-10-12-21(13-11-14)19(23)15-6-8-17(9-7-15)24-16-4-2-1-3-5-16/h1-9,14H,10-13H2,(H2,20,22)
  • InChiKey: NFSKLASLKOQYJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-(phenoxy)benzoyl]isonipecotamide
  • 1-[4-(phenoxy)phenyl]carbonylpiperidine-4-carboxamide
  • 1-[oxo-[4-(phenoxy)phenyl]methyl]-4-piperidinecarboxamide
  • Enamine_002347
  • MLS000565020
  • Oprea1_706686
  • SMR000152207
  • T0506-6047
  • ZINC03234341

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.121 0.1228
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0184 0.0225
Leishmania major eukaryotic initiation factor 4a, putative 0.0329 0.8163 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0171 0.4169 0.5107
Brugia malayi PAS domain containing protein 0.0055 0.1264 0.1548
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0426 0.1487
Schistosoma mansoni cpg binding protein 0.0028 0.0588 0.0588
Onchocerca volvulus 0.0028 0.0588 0.072
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0426 0.0107
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0426 0.1487
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.121 0.1228
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.0022 0.0022
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0022 0.0426 0.0238
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0237 0.0237
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0184 0.0225
Brugia malayi tailless protein 0.0006 0.0022 0.0027
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0022 0.0027
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0237 0.0245
Brugia malayi nuclear hormone receptor 0.0012 0.0184 0.0225
Brugia malayi CXXC zinc finger family protein 0.0028 0.0588 0.072
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0097 0.0097
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0426 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0184 0.0225
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0022 0.0027
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0329 0.8163 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0237 0.0237
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0038 0.0000000045436
Brugia malayi hypoxia-induced factor 1 0.0171 0.4169 0.5107
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.121 0.1228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0184 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0184 0.0225
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0184 0.0184
Brugia malayi hypothetical protein 0.0148 0.3598 0.4408
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1443
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0184 0.0184
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0039 0.0048
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0022 0.0027
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0329 0.8163 1
Mycobacterium leprae putative cytochrome p450 0.0022 0.0426 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0184 0.0184
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1243 0.1243
Loa Loa (eye worm) cytochrome P450 0.0022 0.0426 0.0522
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0426 0.0107
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0329 0.8163 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0426 0.0107
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0184 0.0184
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.121 0.121
Trypanosoma brucei protein kinase, putative 0.0053 0.121 0.111
Leishmania major protein kinase, putative 0.0015 0.025 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0054 0.0054
Schistosoma mansoni rab6-interacting 0.0019 0.0365 0.0365
Schistosoma mansoni zinc finger protein 0.0006 0.0022 0.0022
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.121 0.121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045436
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0039 0.0039
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0426 0.1487
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0426 0.1487
Schistosoma mansoni cytochrome P450 0.0022 0.0426 0.0426
Echinococcus granulosus single minded 2 0.0041 0.0903 0.0903
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0237 0.0291
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.121 0.121
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0048
Schistosoma mansoni hypothetical protein 0.0402 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0184 0.0225
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0054 0.0054
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0184 0.0184
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0903 0.1107
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0184 0.0225
Brugia malayi hypothetical protein 0.0006 0.0022 0.0027
Schistosoma mansoni lipoxygenase 0.0019 0.0365 0.0365
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0097 0.0119
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0343 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0329 0.8163 1
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0022 0.0022
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0329 0.8163 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0184 0.0225
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0588 0.072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0365 0.0447
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0893 0.1093
Leishmania major cytochrome p450-like protein 0.0022 0.0426 0.0238
Echinococcus multilocularis cpg binding protein 0.003 0.0628 0.0628
Echinococcus granulosus eukaryotic initiation factor 4A 0.0329 0.8163 0.8163
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0329 0.8163 1
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0365 0.0447
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0426 0.0238
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0237 0.0291
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.0022 0.0022
Onchocerca volvulus Huntingtin homolog 0.0148 0.3598 0.4408
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0426 0.0107
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0329 0.8163 0.8163
Brugia malayi nuclear receptor RXR 0.0006 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0426 0.1487
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.1897 0.2324
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0184 0.0225
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0054 0.0054
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0343 0.042
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0094 0.0115
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0426 0.1487
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0343 0.0133
Schistosoma mansoni ap endonuclease 0.0019 0.0343 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0184 0.0225
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0426 0.0107
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0343 0.0375
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Onchocerca volvulus 0.0019 0.0365 0.0447
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0343 0.0133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0365 0.0029
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.121 0.111
Plasmodium falciparum eukaryotic initiation factor 4A 0.0329 0.8163 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Onchocerca volvulus 0.0014 0.0237 0.0291
Leishmania major protein kinase, putative 0.0015 0.025 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0184 0.0184
Brugia malayi steroid hormone receptor 0.0012 0.0184 0.0225
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0237 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0184 0.0225
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0343 0.0343
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0039 0.0039
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0426 0.1487
Onchocerca volvulus 0.0041 0.0903 0.1107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0184 0.0184
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.121 0.111
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0426 0.0107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1385 0.1385
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0426 0.0107
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0184 0.0184
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0237 0.0237
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0237 0.0245
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Loa Loa (eye worm) DR-78 0.0006 0.0022 0.0027
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0426 0.1487
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0426 0.0107
Onchocerca volvulus 0.0006 0.0022 0.0027
Onchocerca volvulus 0.0255 0.6293 0.7709
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.0022 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0184 0.0184
Leishmania major eukaryotic initiation factor 4a, putative 0.0329 0.8163 1
Schistosoma mansoni single-minded 0.0055 0.1264 0.1264
Schistosoma mansoni cpg binding protein 0.003 0.0628 0.0628
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045436
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0184 0.0184
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0184 0.0184
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1243 0.1243
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Brugia malayi Cytochrome P450 family protein 0.004 0.0893 0.1093
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0426 0.1487
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.025 0.0015
Schistosoma mansoni polycystin 1-related 0.0019 0.0365 0.0365
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0426 0.1487
Schistosoma mansoni lipoxygenase 0.0054 0.1243 0.1243
Echinococcus multilocularis dnaJ subfamily B 0.0402 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0365 0.0365
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0184 0.0184
Brugia malayi nuclear receptor NHR-88 0.0006 0.0022 0.0027
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0237 0.0245
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0426 0.1487
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0184 0.0225
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0184 0.0225
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0184 0.0184
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0426 0.1487
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0426 0.0426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0184 0.0225
Plasmodium vivax RNA helicase-1, putative 0.0329 0.8163 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0426 0.1487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0184 0.0225
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0426 0.0107
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0184 0.0225
Schistosoma mansoni hypothetical protein 0.0022 0.0426 0.0426
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.121 0.1228
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0426 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1443
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.0022 0.0022
Brugia malayi nuclear hormone receptor 0.0006 0.0022 0.0027
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0343 0.042
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0048
Loa Loa (eye worm) pax transcription factor protein 2 0.0255 0.6293 0.7709
Schistosoma mansoni rab6-interacting 0.0019 0.0365 0.0365
Onchocerca volvulus 0.0019 0.0365 0.0447
Schistosoma mansoni ap endonuclease 0.0019 0.0343 0.0343
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0054 0.0054
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0426 0.1487
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0343 0.0375
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0237 0.0245
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0426 0.0238
Brugia malayi ecdysone receptor 0.0006 0.0022 0.0027
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0329 0.8163 0.8163
Loa Loa (eye worm) CYP4Cod1 0.004 0.0893 0.1093
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0039 0.0039
Echinococcus multilocularis RUN 0.0019 0.0365 0.0365
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045436
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0184 0.0184
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0426 0.0107
Onchocerca volvulus 0.0012 0.0184 0.0225
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.025 0.0015
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0184 0.0225
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Brugia malayi hypothetical protein 0.0019 0.0365 0.0447
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.4529 0.5548
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0426 0.0107
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0329 0.8163 1
Brugia malayi hypothetical protein 0.0006 0.0039 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0184 0.0184
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0039 0.0048
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0237 0.0237
Brugia malayi nuclear receptor RXR 0.0006 0.0039 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0184 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0184 0.0225
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0019 0.0365 0.0447
Schistosoma mansoni loxhd1 0.0019 0.0365 0.0365
Brugia malayi hypothetical protein 0.0006 0.0039 0.0048
Brugia malayi Doublecortin family protein 0.0019 0.0365 0.0447
Leishmania major cytochrome p450-like protein 0.004 0.0893 0.0826
Schistosoma mansoni nuclear receptor 0.0006 0.0022 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0184 0.0184
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0022 0.0022
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0237 0.0245
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0426 0.0107
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.025 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0426 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0184 0.0225
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0426 0.1487
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0426 0.0238
Mycobacterium ulcerans putative regulatory protein 0.0041 0.0903 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.3598 0.4408
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0426 0.0107
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0022 0.0027
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0329 0.8163 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0426 0.1487
Trypanosoma brucei cytochrome P450, putative 0.004 0.0893 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0184 0.0225
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0426 0.1487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0329 0.8163 0.8163
Loa Loa (eye worm) hypothetical protein 0.0148 0.3598 0.4408
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.121 0.121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045436
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0893 0.9806
Brugia malayi hypothetical protein 0.0006 0.0022 0.0027
Brugia malayi Cytochrome P450 family protein 0.004 0.0893 0.1093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0426 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1443
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.0022 0.0022
Brugia malayi cytochrome P450 0.0022 0.0426 0.0522
Schistosoma mansoni cpg binding protein 0.003 0.0628 0.0628
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0344 0.0421
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.1264 0.1264
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0893 0.0826
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.0022 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0893 0.0826
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0184 0.0225
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0054 0.0054
Brugia malayi nuclear receptor NHR-67 0.0006 0.0022 0.0027
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0426 0.1487
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0237 0.0245
Schistosoma mansoni nuclear receptor 0.0006 0.0022 0.0022
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.121 0.111
Echinococcus granulosus RUN 0.0019 0.0365 0.0365
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0184 0.0225
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1443
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Brugia malayi ecdysteroid receptor 0.0012 0.0184 0.0225
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1224 0.1127
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0022 0.0027
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0426 0.1487
Brugia malayi hypothetical protein 0.0185 0.4529 0.5548
Schistosoma mansoni hypothetical protein 0.0019 0.0365 0.0365
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0237 0.0245
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0426 1
Echinococcus granulosus cpg binding protein 0.003 0.0628 0.0628
Schistosoma mansoni coup transcription factor 0.0012 0.0184 0.0184
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0184 0.0184
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0426 0.1487
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.121 0.1483
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045436
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0237 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0184 0.0225
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0184 0.0184
Brugia malayi eukaryotic initiation factor 4A 0.0329 0.8163 1
Brugia malayi hypothetical protein 0.0019 0.0365 0.0447
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0237 0.0245
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0184 0.0225
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0893 0.1093
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0426 0.0107
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0343 0.0343
Brugia malayi MAP kinase sur-1 0.0053 0.121 0.1483
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0097 0.0097
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0329 0.8163 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0903 0.0903
Brugia malayi Pax transcription factor protein 2 0.0255 0.6293 0.7709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0184 0.0225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0184 0.0184
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0237 0.0245
Treponema pallidum ATP-dependent RNA helicase 0.0329 0.8163 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0426 0.0107
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0365 0.0029
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.121 0.1228
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0237 0.0245
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0426 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0329 0.8163 0.8163
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0426 0.0107
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0329 0.8163 0.8163
Brugia malayi Cytochrome P450 family protein 0.0022 0.0426 0.0522
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0022 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0184 0.0184
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.121 0.1228
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0022 0.0027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.008 0.1897 0.2324
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0022 0.0027
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0022 0.0027
Onchocerca volvulus 0.0006 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0343 0.0133
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045436
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0184 0.0184
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0022 0.0027
Brugia malayi nuclear receptor NHR-88 0.0012 0.0184 0.0225
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0329 0.8163 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0225
Brugia malayi conserved hypotetical protein 0.0006 0.0022 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0039 0.0048
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0329 0.8163 1
Echinococcus multilocularis 0.0022 0.0426 0.0426
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0038 0.0000000045436
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0039 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0426 0.0107
Loa Loa (eye worm) hypothetical protein 0.0329 0.8163 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0184 0.0225
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0365 0.0365
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.121 0.121
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0022 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0426 0.0107
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0048
Onchocerca volvulus Huntingtin homolog 0.0148 0.3598 0.4408

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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