Detailed information for compound 1263874

Basic information

Technical information
  • TDR Targets ID: 1263874
  • Name: [2-[(1,1-dioxothiolan-3-yl)-ethylamino]-2-oxo ethyl] 4-fluoro-3-morpholin-4-ylsulfonylbenzo ate
  • MW: 492.539 | Formula: C19H25FN2O8S2
  • H donors: 0 H acceptors: 6 LogP: 0.12 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C1CCS(=O)(=O)C1)C(=O)COC(=O)c1ccc(c(c1)S(=O)(=O)N1CCOCC1)F
  • InChi: 1S/C19H25FN2O8S2/c1-2-22(15-5-10-31(25,26)13-15)18(23)12-30-19(24)14-3-4-16(20)17(11-14)32(27,28)21-6-8-29-9-7-21/h3-4,11,15H,2,5-10,12-13H2,1H3
  • InChiKey: RZFWRNWUFBTUTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(1,1-dioxothiolan-3-yl)-ethyl-amino]-2-oxo-ethyl] 4-fluoro-3-morpholinosulfonyl-benzoate
  • 4-fluoro-3-morpholinosulfonylbenzoic acid [2-[(1,1-dioxo-3-thiolanyl)-ethylamino]-2-oxoethyl] ester
  • 4-fluoro-3-morpholinosulfonyl-benzoic acid [2-[(1,1-diketothiolan-3-yl)-ethyl-amino]-2-keto-ethyl] ester
  • [2-[(1,1-dioxothiolan-3-yl)-ethyl-amino]-2-oxo-ethyl] 4-fluoro-3-morpholin-4-ylsulfonyl-benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase eta 0.002 0.0041 0.0048
Brugia malayi Bromodomain containing protein 0.0155 0.1694 0.4667
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0181 0.0213
Echinococcus multilocularis lamin 0.0028 0.0137 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0595 0.0701
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0123 0.0235
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0123 0.0811
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0229 0.027
Echinococcus multilocularis endoplasmin 0.0027 0.0123 0.0123
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0115 0.0212
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0115 0.0115
Echinococcus granulosus cathepsin b 0.0313 0.3629 0.428
Brugia malayi heat shock protein 90 0.0033 0.0207 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0181 0.0497
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.13 0.3581
Brugia malayi PHD-finger family protein 0.003 0.0165 0.0454
Brugia malayi nuclear hormone receptor 0.0031 0.0181 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0181 0.0497
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0181 0.0213
Brugia malayi MH2 domain containing protein 0.0123 0.13 0.3581
Brugia malayi hypothetical protein 0.0043 0.033 0.0909
Echinococcus granulosus lamin dm0 0.0028 0.0137 0.0162
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0004
Giardia lamblia PHD finger protein 15 0.003 0.0165 0.1214
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0481 0.0481
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0481 0.1325
Brugia malayi Ets-domain containing protein 0.0087 0.0869 0.2395
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0207 0.0467
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0181 0.0213
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0115 0.0136
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0165 0.0454
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0181 0.0181
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0181 0.0213
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0181 0.0213
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0207 0.1626
Trichomonas vaginalis heat shock protein, putative 0.002 0.0049 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0229 0.027
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0405 0.1115
Schistosoma mansoni intermediate filament proteins 0.0028 0.0137 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0181 0.0213
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0279 0.0329
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0398 0.217
Schistosoma mansoni hypothetical protein 0.0032 0.0185 0.0218
Brugia malayi PHD-finger family protein 0.0051 0.0428 0.1178
Loa Loa (eye worm) hypothetical protein 0.0075 0.0714 0.1967
Echinococcus multilocularis cathepsin b 0.0313 0.3629 0.3629
Brugia malayi jmjC domain containing protein 0.0026 0.0115 0.0318
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.4925
Brugia malayi intermediate filament protein 0.0028 0.0137 0.0378
Echinococcus granulosus heat shock protein 90 0.0033 0.0207 0.0244
Echinococcus multilocularis dna polymerase kappa 0.002 0.0041 0.0041
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0207 0.1626
Schistosoma mansoni zinc finger protein 0.004 0.0293 0.0345
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0181 0.0181
Brugia malayi jmjC domain containing protein 0.0026 0.0115 0.0318
Plasmodium vivax hypothetical protein, conserved 0.003 0.0165 0.5388
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0041 0.0112
Echinococcus granulosus endoplasmin 0.0027 0.0123 0.0146
Echinococcus granulosus phd:f box containing protein 0.0026 0.0115 0.0136
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2773 0.327
Echinococcus multilocularis lamin dm0 0.0028 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.011 0.1149 0.3166
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0126 0.1339 0.369
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2163 0.255
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0497
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0398 0.0469
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0181 0.0213
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0313 0.3629 0.428
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0628 0.5753
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0115 0.0318
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Echinococcus granulosus lysine specific demethylase 5A 0.0101 0.1037 0.1223
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0115 0.0136
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0123 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0628 0.1641
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0115 0.0136
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0041 0.0004
Echinococcus multilocularis zinc finger protein 0.004 0.0293 0.0293
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0041 0.0048
Schistosoma mansoni hypothetical protein 0.0043 0.033 0.0389
Echinococcus granulosus dna polymerase kappa 0.002 0.0041 0.0048
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2773 0.2773
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0181 0.0497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.033 0.0389
Plasmodium vivax endoplasmin, putative 0.0033 0.0207 1
Onchocerca volvulus 0.0031 0.0181 0.0361
Plasmodium falciparum heat shock protein 90 0.0033 0.0207 1
Brugia malayi jmjC domain containing protein 0.0026 0.0115 0.0318
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0398 0.0469
Schistosoma mansoni hypothetical protein 0.0298 0.3446 0.4064
Echinococcus multilocularis musashi 0.0028 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0112
Brugia malayi RNA binding protein 0.0065 0.0595 0.1639
Schistosoma mansoni ets-related 0.0265 0.305 0.3597
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0165 0.0194
Onchocerca volvulus 0.005 0.0405 0.2226
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Brugia malayi hypothetical protein 0.0126 0.1339 0.369
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2163 0.2163
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0181 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0595 0.0701
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.1307 0.1541
Echinococcus multilocularis cathepsin b 0.0313 0.3629 0.3629
Loa Loa (eye worm) hypothetical protein 0.0028 0.0137 0.0378
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0181 0.0181
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.4925
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.848 0.848
Echinococcus granulosus lamin 0.0028 0.0137 0.0162
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0137 0.0378
Onchocerca volvulus 0.0049 0.0398 0.217
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0244 0.0674
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0628 0.1731
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0207 0.0467
Loa Loa (eye worm) cathepsin B 0.0103 0.1062 0.2927
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.1307 0.1307
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0628 0.0628
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0181 0.0181
Echinococcus multilocularis heat shock protein 90 0.0027 0.0123 0.0123
Plasmodium falciparum phd finger protein, putative 0.003 0.0165 0.7335
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0229 0.027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0181 0.0213
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0115 0.0115
Schistosoma mansoni bromodomain containing protein 0.0131 0.1398 0.1648
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0229 0.0229
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0628 0.5753
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0181 0.0213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0181 0.0497
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0481 0.0567
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0497
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0181 0.0497
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0181 0.0497
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.0123 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0159 0.1746 0.2059
Echinococcus granulosus geminin 0.0174 0.193 0.2276
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0398 0.0469
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0318
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0454
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0123 0.0811
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0164 0.0193
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0318
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0595 0.1639
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0229 0.027
Loa Loa (eye worm) hypothetical protein 0.0049 0.0398 0.1096
Brugia malayi Endoplasmin precursor 0.0033 0.0207 0.057
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0207 0.0965
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0115 0.0136
Brugia malayi Bromodomain containing protein 0.0035 0.0224 0.0619
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0181 0.0213
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0004
Brugia malayi jmjC domain containing protein 0.0026 0.0115 0.0318
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0207 1
Brugia malayi Fli-1 protein 0.0265 0.305 0.8404
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.011 0.1149 0.3166
Schistosoma mansoni endoplasmin 0.0033 0.0207 0.0244
Schistosoma mansoni survival motor neuron protein 0.005 0.0405 0.0477
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0137 0.0378
Leishmania major hypothetical protein, conserved 0.0026 0.0115 0.0732
Toxoplasma gondii cathepsin B 0.0103 0.1062 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0497
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0869 0.2395
Brugia malayi jmjC domain containing protein 0.0159 0.1746 0.4811
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0181 0.0213
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0628 0.0741
Echinococcus granulosus intermediate filament protein 0.0028 0.0137 0.0162
Loa Loa (eye worm) endoplasmin 0.0033 0.0207 0.057
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0313 0.3629 0.428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0181 0.0497
Echinococcus granulosus zinc finger protein 0.004 0.0293 0.0345
Giardia lamblia Cathepsin B precursor 0.0103 0.1062 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0368 0.0434
Loa Loa (eye worm) hypothetical protein 0.0243 0.2773 0.764
Schistosoma mansoni hypothetical protein 0.0043 0.0319 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0181 0.0497
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.1037 0.1223
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0004
Schistosoma mansoni hypothetical protein 0.005 0.0405 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0181 0.0497
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0123 0.0235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0181 0.0181
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0115 0.0136
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0123 0.5
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0181 0.0497
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0313 0.3629 1
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0207 0.1626
Trypanosoma cruzi ISWI complex protein 0.0032 0.0185 0.0405
Giardia lamblia Cathepsin B precursor 0.0103 0.1062 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0181 0.0497
Echinococcus granulosus heat shock protein 90 0.0027 0.0123 0.0146
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0194
Loa Loa (eye worm) hypothetical protein 0.0027 0.0131 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0181 0.0497
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0229 0.027
Echinococcus granulosus cathepsin b 0.0313 0.3629 0.428
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0368 0.0368
Echinococcus granulosus tar DNA binding protein 0.0065 0.0595 0.0701
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0165 0.0194
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0229 0.027
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0041 0.0004
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0111 0.1156 0.3185
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0497
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0869 0.0869
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0706 0.0833
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0181 0.0181
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Brugia malayi photoreceptor-specific nuclear receptor 0.0274 0.315 0.868
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0165 0.0165
Brugia malayi jmjC domain containing protein 0.0101 0.1037 0.2857
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0115 0.0136
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0319 0.088
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0497
Schistosoma mansoni coup transcription factor 0.0031 0.0181 0.0213
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0112
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0595 0.1639
Loa Loa (eye worm) hypothetical protein 0.0079 0.0768 0.2116
Schistosoma mansoni lamin 0.0028 0.0137 0.0162
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0115 0.0136
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0313 0.3629 0.428
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0181 0.0497
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0137 0.0378
Giardia lamblia Cathepsin B precursor 0.0103 0.1062 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0595 0.0701
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0123 0.0811
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0123 1
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0207 0.1626
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0308 0.0308
Echinococcus multilocularis geminin 0.0174 0.193 0.193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0181 0.0497
Brugia malayi hypothetical protein 0.0243 0.2773 0.764
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0207 0.0467
Loa Loa (eye worm) hypothetical protein 0.0068 0.0626 0.1724
Loa Loa (eye worm) hypothetical protein 0.0313 0.3629 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0628 0.1641
Echinococcus granulosus peregrin 0.0035 0.0224 0.0265
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0181 0.0181
Echinococcus multilocularis transcription factor eb 0.0111 0.1156 0.1156
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Schistosoma mansoni endoplasmin 0.0033 0.0207 0.0244
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0869 0.1025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0181 0.0181
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0115 0.0318
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0181 0.0497
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0368 0.0434
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0481 0.0567
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0181 0.0497
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0164 0.0164
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Schistosoma mansoni lamin 0.0028 0.0137 0.0162
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0041 0.0048
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0481 0.0567
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0181 0.0361
Loa Loa (eye worm) hypothetical protein 0.0088 0.0876 0.2414
Trypanosoma brucei ISWI complex protein 0.0032 0.0185 0.1409
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0207 0.0467
Trichomonas vaginalis endoplasmin, putative 0.002 0.0049 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0103 0.1062 1
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0398 0.1096
Loa Loa (eye worm) hypothetical protein 0.0274 0.315 0.868
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0279 0.0279
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0181 0.0497
Loa Loa (eye worm) hypothetical protein 0.0056 0.0481 0.1325
Brugia malayi TAR-binding protein 0.0065 0.0595 0.1639
Echinococcus multilocularis heat shock protein 0.0033 0.0207 0.0207
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0595 0.1639
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0181 0.0361
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0207 0.2827
Trypanosoma brucei cysteine peptidase C (CPC) 0.0103 0.1062 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0181 0.0213
Treponema pallidum heat shock protein 90 0.0027 0.0123 0.5
Echinococcus granulosus transcription factor eb 0.0111 0.1156 0.1363
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0628 1
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0181 0.0497
Brugia malayi cathepsin B-like cysteine proteinase 0.0313 0.3629 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0181 0.0497
Schistosoma mansoni jumonji domain containing protein 0.0139 0.1499 0.1768
Loa Loa (eye worm) hypothetical protein 0.0146 0.1586 0.4369
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0123 0.0811
Echinococcus granulosus microtubule associated protein 2 0.0709 0.848 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0112
Brugia malayi steroid hormone receptor 0.0031 0.0181 0.0497
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0628 0.1731
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.848 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0828 0.2281
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0207 0.057
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0207 0.2827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0181 0.0497
Echinococcus multilocularis dna polymerase eta 0.002 0.0041 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0229 0.0229
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0308 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0181 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0181 0.0497
Brugia malayi ecdysteroid receptor 0.0031 0.0181 0.0497
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0398 0.0398
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.4925
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0181 0.0213
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.033 0.0389
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0123 0.0146
Loa Loa (eye worm) fli-1 protein 0.0265 0.305 0.8404
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.4925
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.033 0.033
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0398 0.0398
Giardia lamblia Grp94/Hsp90 0.0027 0.0123 0.0811
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Schistosoma mansoni hypothetical protein 0.0174 0.193 0.2276
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0165 0.052
Schistosoma mansoni zinc finger protein 0.0032 0.0185 0.0218
Echinococcus granulosus dna polymerase eta 0.002 0.0041 0.0048
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0103 0.1062 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0706 0.0706
Schistosoma mansoni heat shock protein 0.0033 0.0207 0.0244
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0115 0.0136
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0398 0.0469
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0398 0.0469
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0497
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0181 0.0361
Brugia malayi Bromodomain containing protein 0.0079 0.0766 0.2111
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0497
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0595 0.0701
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0115 0.0212
Onchocerca volvulus Alhambra homolog 0.003 0.0165 0.0229
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0181 0.0213
Echinococcus multilocularis lysine specific demethylase 5A 0.0097 0.0989 0.0989
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0115 0.0732
Echinococcus multilocularis heat shock protein 90 0.0033 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0174 0.193 0.2276
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0181 0.0497
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0165 0.052
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0181 0.0213
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0207 0.1626
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0115 0.4221
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0628 0.0741
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0181 0.0213
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0207 0.0965
Onchocerca volvulus Huntingtin homolog 0.0126 0.1339 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0103 0.1062 0.285
Loa Loa (eye worm) hypothetical protein 0.0126 0.1339 0.369
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.13 0.3581
Brugia malayi Ets-domain containing protein 0.0087 0.0869 0.2395
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0595 0.0595
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0595 0.0701
Schistosoma mansoni gabp alpha 0.0087 0.0869 0.1025
Schistosoma mansoni heat shock protein 0.0033 0.0207 0.0244
Brugia malayi nuclear receptor NHR-88 0.0031 0.0181 0.0497
Loa Loa (eye worm) jmjC domain-containing protein 0.0101 0.1037 0.2857
Echinococcus granulosus heat shock protein 0.0033 0.0207 0.0244
Echinococcus multilocularis peregrin 0.0035 0.0224 0.0224
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0123 0.0811
Loa Loa (eye worm) RNA binding protein 0.0065 0.0595 0.1639
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0115 0.0318
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0181 0.0213
Leishmania major hypothetical protein, conserved 0.0032 0.0185 0.1409
Trypanosoma cruzi ISWI complex protein 0.0032 0.0185 0.0405
Brugia malayi mbt repeat family protein 0.0049 0.0398 0.1096
Brugia malayi mbt repeat family protein 0.0049 0.0398 0.1096
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0181 0.0213
Trypanosoma brucei heat shock protein, putative 0.0033 0.0207 0.1626
Leishmania major heat shock protein 83-1 0.0033 0.0207 0.1626
Onchocerca volvulus Huntingtin homolog 0.0126 0.1339 1
Loa Loa (eye worm) MBCTL1 0.0056 0.0481 0.1325
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0115 0.0115
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0181 0.0213
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0207 0.0467
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0555 0.153
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.1037 0.1223
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0313 0.3629 0.428
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0159 0.1746 0.1746
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0103 0.1062 0.1253

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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