Detailed information for compound 1264483

Basic information

Technical information
  • TDR Targets ID: 1264483
  • Name: [2-(4-methoxyphenyl)quinolin-4-yl]-(4-phenylp iperazin-1-yl)methanone
  • MW: 423.506 | Formula: C27H25N3O2
  • H donors: 0 H acceptors: 2 LogP: 4.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nc2ccccc2c(c1)C(=O)N1CCN(CC1)c1ccccc1
  • InChi: 1S/C27H25N3O2/c1-32-22-13-11-20(12-14-22)26-19-24(23-9-5-6-10-25(23)28-26)27(31)30-17-15-29(16-18-30)21-7-3-2-4-8-21/h2-14,19H,15-18H2,1H3
  • InChiKey: SQFODJWPGSAXQN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [2-(4-methoxyphenyl)-4-quinolyl]-(4-phenylpiperazin-1-yl)methanone
  • [2-(4-methoxyphenyl)-4-quinolyl]-(4-phenyl-1-piperazinyl)methanone
  • Oprea1_414186
  • ZINC03215915
  • T0505-6617
  • MLS001017643
  • SMR000353937

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Saccharomyces cerevisiae Rce1p Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans ras and a-factor terminal proteolysis Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis CAAX prenyl protease 2 Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Hypothetical protein Get druggable targets OG5_129169 All targets in OG5_129169
Schistosoma japonicum ko:K08658 prenyl protein peptidase, putative Get druggable targets OG5_129169 All targets in OG5_129169
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans ras and a-factor terminal proteolysis Get druggable targets OG5_129169 All targets in OG5_129169
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica CAAX prenyl protease family Get druggable targets OG5_129169 All targets in OG5_129169
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense CAAX amino terminal protease, putative Get druggable targets OG5_129169 All targets in OG5_129169
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus CAAX prenyl protease 2 Get druggable targets OG5_129169 All targets in OG5_129169
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi CAAX prenyl protease 2, putative Get druggable targets OG5_129169 All targets in OG5_129169
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni family U48 unassigned peptidase (U48 family) Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani CAAX prenyl protease 2, putative Get druggable targets OG5_129169 All targets in OG5_129169
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48), putative Get druggable targets OG5_129169 All targets in OG5_129169
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni family U48 unassigned peptidase (U48 family) Get druggable targets OG5_129169 All targets in OG5_129169
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei CAAX amino terminal protease, putative Get druggable targets OG5_129169 All targets in OG5_129169
Schistosoma japonicum expressed protein Get druggable targets OG5_129169 All targets in OG5_129169
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi CAAX amino terminal protease family protein Get druggable targets OG5_129169 All targets in OG5_129169
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) Get druggable targets OG5_129169 All targets in OG5_129169
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0025 0.5
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0111 0.0176 0.0423
Loa Loa (eye worm) phosphatidylinositol 3 0.0354 0.0726 0.1209
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.3016 0.6728 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0106 0.0165 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Entamoeba histolytica CAAX prenyl protease family 0.0111 0.0176 0.0423
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0354 0.0726 0.5742
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0106 0.0165 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0025 0.0001
Giardia lamblia GTOR 0.0354 0.0726 0.3492
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0025 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0062 0.0173
Onchocerca volvulus 0.0043 0.0025 0.0728
Mycobacterium leprae conserved hypothetical protein 0.0106 0.0165 1
Loa Loa (eye worm) hypothetical protein 0.024 0.0468 0.0779
Schistosoma mansoni alpha-glucosidase 0.0169 0.0308 0.0458
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0025 0.5
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0354 0.0726 0.1934
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0479 0.1008 0.2745
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0354 0.0726 0.5742
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.037 0.037
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0354 0.0726 0.1959
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0032
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0522 0.1389
Loa Loa (eye worm) hypothetical protein 0.022 0.0423 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Onchocerca volvulus 0.0114 0.0183 0.5418
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0165 0.2003
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0354 0.0726 0.1079
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0165 0.2003
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0264 0.0522 0.0522
Leishmania major phosphatidylinositol 3-kinase, putative 0.0264 0.0522 0.1371
Plasmodium vivax hypothetical protein 0.0106 0.0165 0.2825
Trypanosoma cruzi target of rapamycin kinase 3 0.0354 0.0726 0.1959
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0264 0.0522 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0585 0.1246 0.3411
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0165 0.0458
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0062 0.0173
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1525 0.3367 0.9334
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0111 0.0176 0.0423
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.022 0.0423 0.1113
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0264 0.0522 0.7092
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0025 0.0001
Schistosoma mansoni hypothetical protein 0.0043 0.0025 0.0036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0165 0.0458
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0106 0.0165 0.0245
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1077 0.2357 0.6536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Schistosoma mansoni hypothetical protein 0.0205 0.0388 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0165 0.0392
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0354 0.0726 0.0726
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0264 0.0522 0.1389
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0585 0.1246 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.037 0.037
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0522 0.1389
Brugia malayi FAT domain containing protein 0.0134 0.0229 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Leishmania major hypothetical protein, conserved 0.1652 0.3652 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0354 0.0726 0.0726
Schistosoma mansoni fkbp-rapamycin associated protein 0.022 0.0423 0.0629
Entamoeba histolytica hypothetical protein 0.131 0.2882 0.7978
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0165 0.0392
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0106 0.0165 0.115
Echinococcus granulosus serine:threonine protein kinase SMG1 0.022 0.0423 0.0423
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.037 0.1027
Schistosoma mansoni hypothetical protein 0.0041 0.0019 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Loa Loa (eye worm) beta-lactamase 0.0043 0.0025 0.0041
Leishmania major phosphatidylinositol 3-kinase, putative 0.0354 0.0726 0.1934
Brugia malayi beta-lactamase family protein 0.0043 0.0025 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0025 0.0001
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0354 0.0726 0.1959
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0264 0.0522 0.1389
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0354 0.0726 0.1959
Plasmodium vivax hypothetical protein, conserved 0.0106 0.0165 0.2825
Mycobacterium ulcerans hypothetical protein 0.0043 0.0025 0.5
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0264 0.0522 0.1448
Mycobacterium ulcerans beta-lactamase 0.0043 0.0025 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0354 0.0726 0.0726
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0427 0.0889 0.4509
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0106 0.0165 0.115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0025 0.0041
Schistosoma mansoni hypothetical protein 0.0106 0.0165 0.0245
Schistosoma mansoni hypothetical protein 0.0134 0.0229 0.0341
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0264 0.0522 0.1389
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0019 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Loa Loa (eye worm) hypothetical protein 0.006 0.0062 0.0104
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1631 0.3606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.022 0.0423 0.1113
Loa Loa (eye worm) hypothetical protein 0.0043 0.0025 0.0041
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.3016 0.6728 0.6728
Echinococcus multilocularis geminin 0.0205 0.0388 0.0388
Onchocerca volvulus 0.0043 0.0025 0.0728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0185 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.022 0.0423 0.1174
Schistosoma mansoni alpha glucosidase 0.0044 0.0025 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1631 0.3606 1
Brugia malayi hypothetical protein 0.0043 0.0025 0.0068
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0134 0.0229 0.0229
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0264 0.0522 0.0522
Brugia malayi beta-lactamase family protein 0.0043 0.0025 0.0068
Giardia lamblia Hypothetical protein 0.0111 0.0176 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0354 0.0726 0.5742
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0165 0.0275
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0165 0.0275
Loa Loa (eye worm) hypothetical protein 0.0043 0.0025 0.0041
Echinococcus granulosus serine protein kinase ATM 0.022 0.0423 0.0423
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0106 0.0165 0.115
Brugia malayi beta-lactamase 0.0043 0.0025 0.0068
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0106 0.0165 0.0393
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0106 0.0165 0.0392
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0264 0.0522 0.0776
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0165 0.0165
Entamoeba histolytica hypothetical protein 0.0106 0.0165 0.0393
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.131 0.2882 0.7978
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0165 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0025 0.0001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0025 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0354 0.0726 0.1959
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0585 0.1246 0.3411
Loa Loa (eye worm) hypothetical protein 0.0106 0.0165 0.0275
Echinococcus granulosus CAAX prenyl protease 2 0.0111 0.0176 0.0176
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0025 0.0001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.037 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0468 0.1238
Echinococcus multilocularis Zinc finger, PHD finger 0.0264 0.0522 0.0522
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1631 0.3606 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0025 0.0068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0165 0.2659
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1631 0.3606 1
Onchocerca volvulus 0.0106 0.0165 0.4884
Trypanosoma brucei glucosidase, putative 0.0044 0.0025 0.0003
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1139 0.2495 0.6899
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0111 0.0176 0.0262
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0553 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0354 0.0726 0.1934
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Loa Loa (eye worm) hypothetical protein 0.0114 0.0185 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.1546 0.3413 0.9462
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0354 0.0726 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.022 0.0423 0.0423
Schistosoma mansoni alpha-glucosidase 0.0169 0.0308 0.0458
Loa Loa (eye worm) hypothetical protein 0.0554 0.1176 0.1958
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0354 0.0726 0.2014
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0025 0.0042
Toxoplasma gondii FATC domain-containing protein 0.022 0.0423 0.5683
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.024 0.0468 0.3629
Leishmania major hypothetical protein, unknown function 0.0106 0.0165 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.037 0.037
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0818 0.1771 1
Echinococcus multilocularis 0.0106 0.0165 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0479 0.1008 0.1678
Toxoplasma gondii target of rapamycin (TOR), putative 0.0354 0.0726 1
Entamoeba histolytica hypothetical protein 0.022 0.0423 0.1113
Echinococcus multilocularis serine protein kinase ATM 0.022 0.0423 0.0423
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1385 0.3049 0.8457
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0522 0.4072
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0025 0.0041
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0106 0.0165 0.0245
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4466 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0106 0.0165 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0025 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1139 0.2495 0.6899
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0025 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0165 0.0392
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0106 0.0165 0.0392
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0025 0.0037
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0106 0.0165 0.0392
Entamoeba histolytica protein kinase rad3, putative 0.022 0.0423 0.1113
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0264 0.0522 0.0869
Entamoeba histolytica hypothetical protein 0.0106 0.0165 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Brugia malayi CAAX amino terminal protease family protein 0.0111 0.0176 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1077 0.2357 0.2357
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0111 0.0176 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Onchocerca volvulus 0.0043 0.0025 0.0728
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0354 0.0726 0.5742
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0165 0.0275
Loa Loa (eye worm) hypothetical protein 0.0043 0.0025 0.0041
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.022 0.0423 0.1113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0185 0.0447
Loa Loa (eye worm) hypothetical protein 0.0182 0.0338 0.0563
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0354 0.0726 0.1934
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Loa Loa (eye worm) hypothetical protein 0.0134 0.0229 0.0382
Loa Loa (eye worm) phosphatidylinositol 3 0.2695 0.6004 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.022 0.0423 0.3263
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Loa Loa (eye worm) hypothetical protein 0.1077 0.2357 0.3925
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0025 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0025 0.0001
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0264 0.0522 0.1389
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0025 0.0025
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.3016 0.6728 0.6728
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0025 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Toxoplasma gondii non-specific serine/threonine protein kinase 0.024 0.0468 0.6321
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0025 0.0025
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1631 0.3606 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0025 0.0025
Echinococcus granulosus geminin 0.0205 0.0388 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0229 0.0572
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0062 0.0104
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0165 0.0165
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0585 0.1246 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0025 0.0025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.022 0.0423 0.1174
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0165 0.0458
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0025 0.0041
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0106 0.0165 0.2825
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0025 0.0069
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0134 0.0229 0.0229
Onchocerca volvulus 0.0182 0.0338 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0025 0.0001
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0106 0.0165 0.2825
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0264 0.0522 0.1371
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0354 0.0726 0.0726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0111 0.0176 0.0262
Echinococcus multilocularis CAAX prenyl protease 2 0.0111 0.0176 0.0176
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0106 0.0165 0.0165
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0111 0.0176 0.0423
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1077 0.2357 0.2357
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0354 0.0726 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0585 0.1246 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0264 0.0522 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0423 0.1113
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0354 0.0726 0.5742
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0264 0.0522 0.0522
Entamoeba histolytica hypothetical protein 0.0106 0.0165 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.024 0.0468 0.1238
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0025 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0354 0.0726 0.2014
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0585 0.1246 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0585 0.1246 0.1852
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0106 0.0165 0.0392
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0165 0.0165
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0106 0.0165 0.0392
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0106 0.0165 0.0392
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1631 0.3606 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0025 0.0041
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0354 0.0726 0.1959
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0165 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0354 0.0726 0.1209
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0264 0.0522 0.1389
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0114 0.0185 0.0447
Loa Loa (eye worm) hypothetical protein 0.0111 0.0176 0.0293
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0354 0.0726 0.1934
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0106 0.0165 0.2825
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1631 0.3606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0726 0.1959
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0264 0.0522 0.7092
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0106 0.0165 0.0392
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0025 0.0006
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0025 0.0025
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0264 0.0522 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0106 0.0165 0.0387
Leishmania major phosphatidylinositol kinase, putative 0.0106 0.0165 0.0387
Schistosoma mansoni hypothetical protein 0.0205 0.0388 0.0577
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.022 0.0423 0.0629
Mycobacterium ulcerans lipase LipD 0.0043 0.0025 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0165 0.2003
Brugia malayi hypothetical protein 0.0182 0.0338 0.0938
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0756 0.1632 0.449
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0585 0.1246 0.3411
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0025 0.0001
Onchocerca volvulus 0.0106 0.0165 0.4884
Trypanosoma brucei CAAX amino terminal protease, putative 0.0111 0.0176 0.124
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0585 0.1246 0.3456

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 4.713 uM PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] ChEMBL. No reference
Potency (functional) 0.1636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.636 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8356 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6855 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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