Detailed information for compound 1265340

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 635.749 | Formula: C38H41N3O6
  • H donors: 3 H acceptors: 4 LogP: 6.36 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(C[C@@H](NC(=O)[C@@H]1CN(C(=O)O1)c1ccccc1)Cc1ccccc1)O)Cc1ccccc1)COc1c(C)cccc1C
  • InChi: 1S/C38H41N3O6/c1-26-13-12-14-27(2)36(26)46-25-35(43)40-32(22-29-17-8-4-9-18-29)33(42)23-30(21-28-15-6-3-7-16-28)39-37(44)34-24-41(38(45)47-34)31-19-10-5-11-20-31/h3-20,30,32-34,42H,21-25H2,1-2H3,(H,39,44)(H,40,43)/t30-,32-,33?,34-/m0/s1
  • InChiKey: XSHNENOGALPUOZ-HESALCJHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Protease   99 aa 102 aa 32.4 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Protease   99 aa 102 aa 32.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.0849 0.2485
Echinococcus multilocularis serine protein kinase ATM 0.0165 0.0412 0.0412
Loa Loa (eye worm) phosphatidylinositol 3 0.0415 0.1162 0.9874
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0105 0.0775
Loa Loa (eye worm) hypothetical protein 0.0177 0.0447 0.3799
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0161 0.1367
Echinococcus multilocularis 6 phosphofructokinase 0.0235 0.062 0.062
Brugia malayi MH2 domain containing protein 0.0353 0.0976 0.8293
Brugia malayi mbt repeat family protein 0.0047 0.0056 0.0472
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0091 0.0091
Loa Loa (eye worm) MH2 domain-containing protein 0.0353 0.0976 0.8292
Loa Loa (eye worm) phosphofructokinase 0.0235 0.062 0.5266
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0084 0.062
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.6996
Plasmodium vivax SET domain protein, putative 0.006 0.0096 0.8633
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0036 0.0258
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0342
Schistosoma mansoni hypothetical protein 0.0082 0.0161 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0293 0.0293
Leishmania major phosphatidylinositol kinase related protein, putative 0.0056 0.0084 0.0234
Echinococcus multilocularis microtubule associated protein 2 0.3356 1 1
Brugia malayi hypothetical protein 0.0123 0.0285 0.2426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.1049 0.7766
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0937 0.6936
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0056 0.0084 0.0084
Brugia malayi 6-phosphofructokinase 0.0235 0.062 0.5268
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0062 0.3791
Mycobacterium ulcerans hypothetical protein 0.004 0.0036 0.0071
Mycobacterium leprae Probable lipase LipE 0.004 0.0036 0.0287
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0084 0.0084
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0415 0.1162 0.1162
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0485 0.0485
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0123 0.0285 0.2423
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0128 0.0299 0.0299
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0084 0.062
Schistosoma mansoni hypothetical protein 0.0177 0.0447 0.0447
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0105 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0084 0.0986
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.0725
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0415 0.1162 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0796 0.5892
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0357 0.0994
Mycobacterium ulcerans glutaminase 0.0279 0.0754 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0415 0.1162 0.3402
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0357 0.1044
Schistosoma mansoni bromodomain containing protein 0.0062 0.0102 0.0102
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0295 0.0295
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0184 0.0469 0.4588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0196 0.1451
Trichomonas vaginalis phosphofructokinase, putative 0.0235 0.062 0.4586
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0165 0.0412 0.3542
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0165 0.0412 0.0412
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0293 0.0796 0.0796
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0056 0.0084 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0036 0.026
Loa Loa (eye worm) hypothetical protein 0.0184 0.0469 0.3981
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.4505 0.4505
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0222 0.0581 0.5
Entamoeba histolytica protein kinase rad3, putative 0.0165 0.0412 0.3545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0096 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0908 0.6722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0796 0.5892
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0056 0.0084 0.0245
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0128 0.0299 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.1021 0.7556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.0223
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0298
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0056 0.0084 0.062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0091 0.0091
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0036 0.0258
Schistosoma mansoni hypothetical protein 0.0363 0.1006 0.1006
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.0469 0.3467
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0415 0.1162 0.3241
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.007 0.0124 0.1047
Toxoplasma gondii 6-phosphofructokinase 0.0063 0.0105 0.1026
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0235 0.062 0.1814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0908 0.6722
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.003 0.0222
Leishmania major ATP-dependent phosphofructokinase 0.0235 0.062 0.1728
Brugia malayi Bromodomain containing protein 0.0074 0.0136 0.1157
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0036 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.1165 0.3415 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0096 0.0933
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.3342 0.9957 0.9957
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0056 0.0056
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0056 0.0084 0.5161
Toxoplasma gondii phosphofructokinase PFKII 0.0063 0.0105 0.1026
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0046 0.0133
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0046 0.0133
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.003 0.0088
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.6996
Toxoplasma gondii hypothetical protein 0.005 0.0065 0.0636
Mycobacterium ulcerans aldehyde dehydrogenase 0.0166 0.0413 0.5289
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0293 0.0293
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0166 0.0413 0.0413
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0293 0.2487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0146 0.0146
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0165 0.0412 0.1205
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0056 0.0084 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.1049 0.7766
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0298
Loa Loa (eye worm) inositol-1 0.0039 0.003 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0909 0.6726
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0096 0.0096
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0056 0.0084 0.0725
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0063 0.0105 0.1026
Toxoplasma gondii FATC domain-containing protein 0.0165 0.0412 0.4032
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.003 0.0222
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0084 0.0712
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0161 0.0161
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0056 0.0084 0.0084
Echinococcus multilocularis 0.0056 0.0084 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0036 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0036 0.0071
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.003 0.0258
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0722
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0082 0.0161 0.0161
Mycobacterium tuberculosis Conserved protein 0.004 0.0036 0.0258
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0235 0.062 0.8993
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0293 0.0796 0.2331
Loa Loa (eye worm) hypothetical protein 0.0049 0.0062 0.0523
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0269 0.0722 0.5341
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0056 0.0084 0.062
Mycobacterium leprae conserved hypothetical protein 0.0056 0.0084 0.1096
Schistosoma mansoni fkbp-rapamycin associated protein 0.0165 0.0412 0.0412
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.003 0.0294
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0084 0.0245
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0063 0.0105 0.0775
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0056 0.0084 0.0716
Leishmania major phosphatidylinositol 3-kinase, putative 0.0293 0.0796 0.2221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0909 0.6726
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0084 0.0712
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0036 0.0258
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.0407 0.5807
Loa Loa (eye worm) hypothetical protein 0.0056 0.0084 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.1021 0.7556
Brugia malayi Bromodomain containing protein 0.0038 0.0028 0.0236
Brugia malayi Glycosyl hydrolases family 31 protein 0.0129 0.0301 0.2561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0242 0.179
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0129 0.0301 0.2558
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0415 0.1162 0.3402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.1021 0.7556
Leishmania major hypothetical protein, unknown function 0.0056 0.0084 0.0234
Mycobacterium leprae conserved hypothetical protein 0.004 0.0036 0.0287
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0293 0.0796 0.0796
Loa Loa (eye worm) 6-phosphofructokinase 0.0235 0.062 0.5266
Loa Loa (eye worm) hypothetical protein 0.0109 0.0242 0.2056
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0235 0.062 0.5333
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0298
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0075 0.0638
Onchocerca volvulus 0.0074 0.0138 0.0781
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0415 0.1162 1
Trichomonas vaginalis glutaminase, putative 0.0279 0.0754 0.5579
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0235 0.062 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0056 0.0084 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0725
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.0482 0.0482
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0084 0.6996
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0036 0.0258
Loa Loa (eye worm) hypothetical protein 0.0128 0.0299 0.2539
Mycobacterium ulcerans beta-lactamase 0.004 0.0036 0.0071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0 0.0004
Loa Loa (eye worm) glutaminase 2 0.0279 0.0754 0.6406
Loa Loa (eye worm) hypothetical protein 0.0053 0.0075 0.0634
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0378 0.105 0.2928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.1049 0.7766
Loa Loa (eye worm) RNA binding protein 0.0126 0.0293 0.2484
Schistosoma mansoni alpha-glucosidase 0.0111 0.0247 0.0247
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0056 0.0084 0.062
Echinococcus granulosus expressed protein 0.0295 0.0801 0.0801
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0084 0.0716
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0084 0.062
Schistosoma mansoni hypothetical protein 0.0128 0.0299 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0036 0.0103
Schistosoma mansoni glutaminase 0.0279 0.0754 0.0754
Trichomonas vaginalis phosphofructokinase, putative 0.0235 0.062 0.4586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0165 0.0412 0.35
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.0326 0.0326
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0293 0.0796 0.2221
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0084 0.5161
Loa Loa (eye worm) hypothetical protein 0.004 0.0035 0.0294
Schistosoma mansoni hypothetical protein 0.0082 0.0161 0.0161
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0056 0.0084 0.0084
Onchocerca volvulus 0.0478 0.1351 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0084 0.0722
Loa Loa (eye worm) hypothetical protein 0.0056 0.0084 0.0712
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0295 0.0295
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0105 1
Schistosoma mansoni 6-phosphofructokinase 0.0235 0.062 0.062
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.003 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0036 0.026
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0105 0.0775
Entamoeba histolytica phosphofructokinase, putative 0.0235 0.062 0.5335
Brugia malayi TAR-binding protein 0.0126 0.0293 0.2487
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0161 0.0161
Leishmania major hypothetical protein, conserved 0.0049 0.0062 0.0172
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0056 0.0152
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.1367
Trichomonas vaginalis set domain proteins, putative 0.0478 0.1351 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0084 0.0821
Echinococcus multilocularis expressed protein 0.0295 0.0801 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.1049 0.7766
Echinococcus granulosus tar DNA binding protein 0.0126 0.0293 0.0293
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0105 0.5
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0326 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.1049 0.7766
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.0447 0.3802
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0084 0.0821
Mycobacterium ulcerans aldehyde dehydrogenase 0.0166 0.0413 0.5289
Brugia malayi Inositol-1 0.0039 0.003 0.0259
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0056 0.0084 0.062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0129 0.0301 0.0301
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0084 0.0084
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0021 0.0021
Brugia malayi beta-lactamase 0.004 0.0036 0.0302
Echinococcus granulosus serine protein kinase ATM 0.0165 0.0412 0.0412
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0415 0.1162 0.1162
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.003 0.0222
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0084 0.0821
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3342 0.9957 0.9957
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0161 0.137
Loa Loa (eye worm) phosphatidylinositol 3 0.0293 0.0796 0.6766
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0937 0.6936
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0131 0.0309 0.2656
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0796 0.5892
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0084 0.0716
Mycobacterium ulcerans hypothetical protein 0.0164 0.0407 0.5201
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0056 0.0084 0.062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.0694 0.5897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0084 0.062
Loa Loa (eye worm) MBCTL1 0.0053 0.0075 0.0634
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.003 0.0084
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0146 0.0146
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0105 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0096 0.0096
Onchocerca volvulus 0.0123 0.0285 0.19
Mycobacterium ulcerans 6-phosphofructokinase 0.0235 0.062 0.8147
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0165 0.0412 0.0412
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0084 0.062
Brugia malayi Pre-SET motif family protein 0.006 0.0096 0.0813
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0075 0.0218
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0056 0.0084 0.062
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0293 0.0796 0.6852
Echinococcus multilocularis GPCR, family 2 0.0082 0.0161 0.0161
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0056 0.0056
Loa Loa (eye worm) transcription factor SMAD2 0.0353 0.0976 0.8292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0909 0.6726
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0105 0.0775
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0293 0.0796 0.2331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0485 0.0485
Entamoeba histolytica hypothetical protein 0.0165 0.0412 0.3545
Echinococcus granulosus GPCR family 2 0.0082 0.0161 0.0161
Toxoplasma gondii target of rapamycin (TOR), putative 0.0368 0.1021 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.1021 0.7556
Brugia malayi RNA binding protein 0.0126 0.0293 0.2487
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0636 0.471
Entamoeba histolytica phosphofructokinase, putative 0.0235 0.062 0.5335
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0161 0.0161
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0056 0.0084 0.062
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0749 0.0749
Trypanosoma cruzi target of rapamycin kinase 3 0.0378 0.105 0.3074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.0694 0.5897
Toxoplasma gondii aldehyde dehydrogenase 0.0166 0.0413 0.4044
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0075 0.0075
Onchocerca volvulus 0.0056 0.0084 0.037
Leishmania major phosphatidylinositol kinase, putative 0.0056 0.0084 0.0234
Entamoeba histolytica hypothetical protein 0.0056 0.0084 0.0725
Trichomonas vaginalis phosphofructokinase, putative 0.0235 0.062 0.4586
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0357 0.3068
Brugia malayi hypothetical protein 0.0032 0.001 0.0082
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0298
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0036 0.0036
Brugia malayi phosphofructokinase 0.0235 0.062 0.5268
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0063 0.0105 0.0194
Echinococcus granulosus 6 phosphofructokinase 0.0235 0.062 0.062
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0105 1
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0036 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0293 0.0293
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0289 0.0783 0.0783
Brugia malayi 6-phosphofructokinase 0.0235 0.062 0.5268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.1021 0.7556
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0056 0.0084 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0084 0.0716
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0293 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0146 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.1162 0.86
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0415 0.1162 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0056 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0293 0.0796 0.6767
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0056 0.0084 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0636 0.471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.1021 0.7556
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0415 0.1162 0.9874
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0036 0.0036
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0056 0.0084 0.0084
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0084 0.0084
Brugia malayi glutaminase DH11.1 0.0279 0.0754 0.6407
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.6996
Schistosoma mansoni aldehyde dehydrogenase 0.0166 0.0413 0.0413
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0415 0.1162 0.3241
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0293 0.2484
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0234
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.0482 0.0482
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.1221 0.3584 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0908 0.6722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0485 0.0485
Brugia malayi mbt repeat family protein 0.0047 0.0056 0.0472
Giardia lamblia GTOR 0.0415 0.1162 1
Schistosoma mansoni hypothetical protein 0.0082 0.0161 0.0161
Echinococcus multilocularis lysosomal alpha glucosidase 0.0129 0.0301 0.0301
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0084 0.0821
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0166 0.0413 0.5902
Mycobacterium ulcerans carboxylesterase, LipT 0.0173 0.0436 0.5599
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0046 0.0133
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0166 0.0413 0.0413
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0235 0.062 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0412 0.3046
Leishmania major phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0234
Schistosoma mansoni hypothetical protein 0.0056 0.0084 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0036 0.0302
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0075 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0036 0.0298
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0084 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0796 0.5892
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0084 0.0084
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0084 0.0821
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0056 0.0084 0.0722
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0036 0.026
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0056 0.0084 0.0245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0485 0.0485
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0062 0.018
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.0849 0.7305
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0245
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0084 0.6996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.1021 0.7556
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0056 0.0056
Schistosoma mansoni inositol monophosphatase 0.0039 0.003 0.003
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.0245
Loa Loa (eye worm) hypothetical protein 0.0101 0.0219 0.186
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0725
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0105 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0636 0.471
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0293 0.0796 0.6852
Loa Loa (eye worm) hypothetical protein 0.0259 0.0694 0.5896
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0293 0.0293
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0056 0.0084 0.0245
Schistosoma mansoni 6-phosphofructokinase 0.0235 0.062 0.062
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0725
Loa Loa (eye worm) hypothetical protein 0.0047 0.0056 0.0468
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.0687 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0084 0.0716
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.0849 0.2485
Loa Loa (eye worm) hypothetical protein 0.0077 0.0146 0.1238
Brugia malayi Pre-SET motif family protein 0.042 0.1177 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0485 0.0485
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.062
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0084 0.0725
Plasmodium vivax hypothetical protein 0.0056 0.0084 0.6996
Onchocerca volvulus 0.0056 0.0084 0.037
Leishmania major hypothetical protein, conserved 0.004 0.0036 0.0098
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0161 0.137
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0165 0.0412 0.1205
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0056 0.0084 0.0725
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0021 0.0021
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0046 0.0392
Brugia malayi beta-lactamase family protein 0.004 0.0036 0.0302
Echinococcus granulosus geminin 0.0363 0.1006 0.1006
Loa Loa (eye worm) hypothetical protein 0.0165 0.0412 0.3498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0909 0.6726
Mycobacterium tuberculosis Carboxylesterase LipT 0.0173 0.0436 0.6238
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0105 0.0775
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.0485 0.4116
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0062 0.018
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0036 0.0071
Schistosoma mansoni microtubule-associated protein tau 0.3356 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0084 0.0716
Schistosoma mansoni inositol monophosphatase 0.0039 0.003 0.003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0166 0.0413 0.1151
Onchocerca volvulus 0.006 0.0096 0.0457
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0326 0.0326
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.0849 0.2368
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0084 0.0716
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0036 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0299 0.2211
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0293 0.0796 0.0796
Brugia malayi FAT domain containing protein 0.0128 0.0299 0.2541
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0062 0.0529
Echinococcus granulosus tumor protein p63 0.0693 0.1996 0.1996
Mycobacterium ulcerans lipase LipD 0.004 0.0036 0.0071
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0084 0.0712
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0165 0.0412 0.3545
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.0665 0.492
Onchocerca volvulus 0.0047 0.0056 0.0152
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0084 0.0712
Entamoeba histolytica hypothetical protein 0.0056 0.0084 0.0725
Echinococcus multilocularis Zinc finger, PHD finger 0.0056 0.0084 0.0084
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0075 0.0075
Leishmania major phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.0234
Brugia malayi hypothetical protein 0.0049 0.0062 0.0526
Mycobacterium tuberculosis Conserved protein 0.004 0.0036 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0242 0.179
Schistosoma mansoni hypothetical protein 0.0127 0.0295 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0293 0.0293
Entamoeba histolytica phosphofructokinase, putative 0.0235 0.062 0.5335
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0036 0.026
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0056 0.0084 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0166 0.0413 0.5289
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0056 0.0084 0.0084
Schistosoma mansoni alpha-glucosidase 0.0111 0.0247 0.0247
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0056 0.0084 0.0084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0036 0.0103
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0056 0.0084 0.0084
Toxoplasma gondii ABC1 family protein 0.004 0.0036 0.0344
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0062 0.0603
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0036 0.026
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0415 0.1162 0.1162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0293 0.2484
Entamoeba histolytica hypothetical protein 0.0056 0.0084 0.0725
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0219 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.1162 0.86
Echinococcus granulosus lysosomal alpha glucosidase 0.0129 0.0301 0.0301
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0105 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0056 0.0084 0.5161
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0063 0.0105 0.0905
Brugia malayi beta-lactamase family protein 0.004 0.0036 0.0302
Mycobacterium tuberculosis Conserved protein 0.004 0.0036 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0777 0.5753
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.0722
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0056 0.0084 0.0084
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0109 0.0242 0.0708
Echinococcus multilocularis tumor protein p63 0.0693 0.1996 0.1996
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0084 0.0245
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0056 0.0084 0.0245
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0298
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0075 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0105 0.0775
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0165 0.0412 0.35
Schistosoma mansoni aldehyde dehydrogenase 0.0166 0.0413 0.0413
Trichomonas vaginalis phosphofructokinase, putative 0.0235 0.062 0.4586
Loa Loa (eye worm) beta-lactamase 0.004 0.0036 0.0298
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0056 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0298
Loa Loa (eye worm) 6-phosphofructokinase 0.0235 0.062 0.5266
Trichomonas vaginalis esterase, putative 0.004 0.0036 0.026
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0056 0.0084 0.062
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.1177 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0412 0.3046
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.003 0.0088
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0056 0.0084 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.0694 0.5896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0796 0.5892
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0056 0.0084 0.0084
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.003 0.0262
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0036 0.0302
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0084 0.0234
Onchocerca volvulus 0.0101 0.0219 0.1396
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0146 0.0146
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0056 0.0468
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0415 0.1162 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0 0.0004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0378 0.105 0.9035
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0165 0.0412 0.0412
Echinococcus multilocularis geminin 0.0363 0.1006 0.1006
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0084 0.062
Entamoeba histolytica hypothetical protein 0.0056 0.0084 0.0725
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0056 0.0084 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0412 0.3046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.1162 0.86
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.0485 0.4118
Loa Loa (eye worm) phosphatidylinositol kinase 0.0056 0.0084 0.0712
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.003 0.5
Loa Loa (eye worm) glutaminase 0.0279 0.0754 0.6406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0363 0.1006 0.1006

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.325 Inhibition of HIV1 protease ChEMBL. 20832304
Ki (binding) = 4731 nM Inhibition of HIV1 protease ChEMBL. 20832304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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