Detailed information for compound 1285099

Basic information

Technical information
  • TDR Targets ID: 1285099
  • Name: 6-(2-chlorophenyl)-4-(4-methylpiperazin-1-yl) quinazoline
  • MW: 338.834 | Formula: C19H19ClN4
  • H donors: 0 H acceptors: 2 LogP: 4.06 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1ncnc2c1cc(cc2)c1ccccc1Cl
  • InChi: 1S/C19H19ClN4/c1-23-8-10-24(11-9-23)19-16-12-14(6-7-18(16)21-13-22-19)15-4-2-3-5-17(15)20/h2-7,12-13H,8-11H2,1H3
  • InChiKey: DFUOIOAZYNYRHR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 6-(2-chlorophenyl)-4-(4-methyl-1-piperazinyl)quinazoline
  • NCGC00010904
  • PCOP-299910

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0488 0.326 0.326
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.0439
Schistosoma mansoni cpg binding protein 0.0033 0.0126 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0158 0.0163
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.006 0.0054
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0058 0.0056
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.0225 0.0225
Brugia malayi Hexokinase family protein 0.0454 0.3023 0.3023
Trypanosoma cruzi metacaspase 5, putative 0.0079 0.0439 0.0437
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0013 0.0013
Onchocerca volvulus 0.0038 0.0158 0.0158
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0007
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.0225 0.0224
Echinococcus granulosus hexokinase type 2 0.1467 1 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0079 0.0439 0.0432
Onchocerca volvulus 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0158 0.0668
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0346 0.2277 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0075 0.0414 0.0413
Echinococcus multilocularis musashi 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Conserved protein 0.0038 0.0158 0.0668
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1039 0.7054 0.7052
Brugia malayi follicle stimulating hormone receptor 0.028 0.1822 0.1822
Echinococcus multilocularis lamin dm0 0.0033 0.0121 0.0121
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0064 0.0335 0.0333
Leishmania major hypothetical protein, conserved 0.1098 0.7455 0.7454
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0335 0.0347
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0158 0.0668
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0651 0.4378 0.4375
Onchocerca volvulus 0.0038 0.0158 0.0158
Leishmania major metacaspase, putative 0.0079 0.0439 0.0437
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0075 0.0414 0.0408
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0551 0.0551
Trichomonas vaginalis CAMK family protein kinase 0.0488 0.326 0.3392
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0158 0.0158
Echinococcus multilocularis Smad4 0.0034 0.0128 0.0128
Leishmania major 6-phosphogluconolactonase 0.0043 0.0191 0.019
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0043 0.0191 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0439 0.0455
Trypanosoma cruzi metacaspase 5, putative 0.0079 0.0439 0.0437
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0301 0.0301
Entamoeba histolytica hypothetical protein 0.0075 0.0413 0.0226
Loa Loa (eye worm) hexokinase 0.0454 0.3023 0.3023
Onchocerca volvulus 0.1467 1 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0121 0.0121
Echinococcus granulosus mitogen activated protein kinase 3 0.0064 0.0335 0.0335
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.157 0.6887
Toxoplasma gondii hexokinase 0.1467 1 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0128 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0488 0.326 0.3392
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0339 0.0339
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.0225 0.0225
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Schistosoma mansoni caspase-7 (C14 family) 0.0295 0.1925 0.1925
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0997 0.6759 0.6759
Echinococcus multilocularis caspase 2 0.0079 0.0439 0.0439
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0128 0.0128
Trypanosoma brucei hexokinase 0.1467 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0158
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0413 0.0413
Loa Loa (eye worm) hexokinase 0.1467 1 1
Loa Loa (eye worm) hypothetical protein 0.1001 0.6788 0.6788
Schistosoma mansoni intermediate filament proteins 0.0033 0.0121 0.0121
Brugia malayi 6-phosphogluconolactonase family protein 0.0043 0.0191 0.0191
Leishmania major protein kinase, putative 0.0018 0.002 0.0019
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0321 0.2104 0.2103
Mycobacterium ulcerans lipase LipD 0.0038 0.0158 0.0106
Plasmodium vivax serine/threonine kinase-1, putative 0.0075 0.0414 0.0408
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0295 0.1925 0.1925
Brugia malayi Hexokinase family protein 0.092 0.6235 0.6235
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0043 0.0191 0.019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0225 0.0035
Onchocerca volvulus 0.1467 1 1
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0043 0.0191 0.0191
Trypanosoma brucei hexokinase 0.1467 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0335 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0414 0.0414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0551 0.0551
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0339 0.0339
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0439 0.0432
Schistosoma mansoni lipoxygenase 0.0142 0.0877 0.0877
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0158 0.0152
Brugia malayi hypothetical protein 0.0024 0.006 0.006
Onchocerca volvulus 0.0024 0.006 0.006
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0126 0.0767 0.0743
Brugia malayi MH2 domain containing protein 0.0034 0.0128 0.0128
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0002 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0158 0.0106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0148 0.0148
Entamoeba histolytica hexokinase 1 0.1467 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0128 0.0128
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0335 0.0347
Echinococcus granulosus lamin 0.0033 0.0121 0.0121
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0488 0.326 0.3259
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.0488 0.326 0.3392
Schistosoma mansoni smad 0.0034 0.0128 0.0128
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0128 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0488 0.326 0.3392
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Echinococcus multilocularis cpg binding protein 0.0033 0.0126 0.0126
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0064 0.0335 0.0333
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.002 0.0019
Mycobacterium ulcerans beta-lactamase 0.0038 0.0158 0.0106
Chlamydia trachomatis 6-phosphogluconolactonase 0.0043 0.0191 0.0281
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0121 0.0121
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0335 0.0347
Echinococcus granulosus single minded 2 0.0043 0.0196 0.0196
Echinococcus granulosus RUN 0.0024 0.006 0.006
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0997 0.6759 0.7016
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0158 0.0157
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.1263 0.1263
Trypanosoma cruzi polo-like protein kinase, putative 0.0488 0.326 0.3259
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0043 0.0191 0.014
Trypanosoma cruzi polo-like protein kinase, putative 0.0488 0.326 0.3259
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0295 0.1925 0.1925
Brugia malayi hypothetical protein 0.0024 0.006 0.006
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0225 0.0225
Trypanosoma cruzi metacaspase, putative 0.0079 0.0439 0.0437
Echinococcus multilocularis mitogen activated protein kinase 0.0064 0.0335 0.0335
Schistosoma mansoni kinase 0.0249 0.161 0.161
Brugia malayi N-terminal motif family protein 0.0198 0.1263 0.1263
Brugia malayi MH2 domain containing protein 0.0494 0.3298 0.3298
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0064 0.0335 0.0335
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0158 0.0668
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0158 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0339 0.0339
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Echinococcus multilocularis hexokinase 0.1467 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0007
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0651 0.4378 0.4524
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0339 0.0339
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0158 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0551 0.0551
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.006 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0158 0.0163
Leishmania major hypothetical protein, conserved 0.0038 0.0158 0.0157
Brugia malayi PAS domain containing protein 0.0059 0.0301 0.0301
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0225 0.0225
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.002 0.0019
Brugia malayi MH1 domain containing protein 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0158
Mycobacterium ulcerans glutaminase 0.141 0.9609 1
Trypanosoma brucei metacaspase MCA3 0.0079 0.0439 0.0432
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0043 0.0191 0.242
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0075 0.0414 0.0413
Loa Loa (eye worm) glutaminase 0.141 0.9609 0.9609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma brucei metacaspase 0.0079 0.0439 0.0432
Trypanosoma brucei protein kinase, putative 0.0064 0.0335 0.0328
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0126 0.0767 0.0797
Trypanosoma cruzi hexokinase, putative 0.1467 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0466 0.3109 0.3109
Echinococcus granulosus hypothetical protein 0.0072 0.0395 0.0395
Leishmania major cytochrome p450-like protein 0.0023 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0395
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0126 0.0767 0.3348
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0058 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0488 0.326 0.3392
Entamoeba histolytica hypothetical protein 0.0075 0.0413 0.0226
Echinococcus granulosus caspase 0.0295 0.1925 0.1925
Echinococcus granulosus caspase 8 0.0079 0.0439 0.0439
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0064 0.0335 0.0333
Brugia malayi CXXC zinc finger family protein 0.0032 0.0114 0.0114
Brugia malayi hexokinase type II 0.0466 0.3109 0.3109
Brugia malayi Cytochrome P450 family protein 0.0023 0.0058 0.0058
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0997 0.6759 0.6696
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0439 0.0455
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0158 0.0158
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0126 0.0767 0.0743
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.002 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.1098 0.7455 0.7454
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0064 0.0335 0.0328
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0129 0.0786 0.3433
Brugia malayi Doublecortin family protein 0.0024 0.006 0.006
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0075 0.0414 0.0413
Brugia malayi beta-lactamase family protein 0.0038 0.0158 0.0158
Brugia malayi hypothetical protein 0.0075 0.0413 0.0413
Echinococcus granulosus caspase 2 0.0079 0.0439 0.0439
Echinococcus granulosus 6 phosphogluconolactonase 0.0043 0.0191 0.0191
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0225 0.0233
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0196 0.0145
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0002 0.0002
Schistosoma mansoni hexokinase 0.1467 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0488 0.326 0.326
Echinococcus granulosus tar DNA binding protein 0.0064 0.0339 0.0339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0551 0.0551
Brugia malayi RNA binding protein 0.0064 0.0339 0.0339
Brugia malayi glucose-6-phosphate dehydrogenase 0.0997 0.6759 0.6759
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0551 0.0551
Schistosoma mansoni smad1 5 8 and 0.0034 0.0128 0.0128
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0121 0.0121
Echinococcus granulosus intermediate filament protein 0.0033 0.0121 0.0121
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0058 0.0058
Trypanosoma brucei 6-phosphogluconolactonase 0.0043 0.0191 0.0185
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0158
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0488 0.326 0.326
Brugia malayi hypothetical protein 0.0197 0.1254 0.1254
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0075 0.0414 0.0408
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0997 0.6759 0.6759
Loa Loa (eye worm) MH2 domain-containing protein 0.0494 0.3298 0.3298
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0158 0.0106
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0064 0.0335 0.0328
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.006 0.006
Brugia malayi MH2 domain containing protein 0.0034 0.0128 0.0128
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.0225 0.0225
Loa Loa (eye worm) glutaminase 2 0.141 0.9609 0.9609
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Trypanosoma cruzi metacaspase, putative 0.0079 0.0439 0.0437
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0002 0.0002
Schistosoma mansoni lamin 0.0033 0.0121 0.0121
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0197 0.1254 0.1254
Entamoeba histolytica serine/threonine protein kinase, putative 0.0488 0.326 0.3129
Brugia malayi serine/threonine-protein kinase plk-2 0.0488 0.326 0.326
Onchocerca volvulus 0.0033 0.0121 0.0121
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0413 0.0413
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0128 0.0128
Loa Loa (eye worm) RNA binding protein 0.0064 0.0339 0.0339
Brugia malayi TAR-binding protein 0.0064 0.0339 0.0339
Echinococcus granulosus Smad4 0.0034 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Giardia lamblia Kinase, CMGC MAPK 0.0064 0.0335 0.0209
Schistosoma mansoni glutaminase 0.141 0.9609 0.9609
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0225 0.0233
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) hexokinase type II 0.1467 1 1
Echinococcus multilocularis RUN 0.0024 0.006 0.006
Treponema pallidum hexokinase (hxk) 0.1467 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0075 0.0414 0.0413
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0158 0.0668
Entamoeba histolytica hypothetical protein 0.0075 0.0413 0.0226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0264 0.0264
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0043 0.0191 0.0191
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0225 0.0225
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0075 0.0414 0.0408
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.0225 0.005
Echinococcus multilocularis citrate lyase subunit beta protein 0.0126 0.0767 0.0767
Loa Loa (eye worm) hexokinase 0.1467 1 1
Schistosoma mansoni loxhd1 0.0024 0.006 0.006
Plasmodium falciparum protein serine/threonine kinase-1 0.0075 0.0414 0.0408
Leishmania major protein kinase, putative 0.0075 0.0414 0.0413
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.1039 0.7054 0.7052
Schistosoma mansoni rab6-interacting 0.0024 0.006 0.006
Brugia malayi MH1 domain containing protein 0.0034 0.0128 0.0128
Mycobacterium leprae Probable lipase LipE 0.0038 0.0158 0.1999
Onchocerca volvulus 0.0015 0.0002 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0158 0.1999
Schistosoma mansoni cpg binding protein 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) hexokinase 0.092 0.6235 0.6235
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0007
Echinococcus granulosus cpg binding protein 0.0033 0.0126 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0551 0.0551
Plasmodium vivax metacaspase 1, putative 0.0079 0.0439 0.0432
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0997 0.6759 0.6758
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0158 0.0157
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.0225 0.0225
Echinococcus granulosus smad 0.0034 0.0128 0.0128
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0225 0.0224
Echinococcus multilocularis 0.0072 0.0395 0.0395
Loa Loa (eye worm) doublecortin family protein 0.0024 0.006 0.006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0005
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0196 0.0196
Schistosoma mansoni lipoxygenase 0.01 0.0582 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.1098 0.7455 0.7454
Brugia malayi MAP kinase sur-1 0.0064 0.0335 0.0335
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0264 0.0264
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0053 0.0264 0.0264
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0414 0.0429
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.0439
Giardia lamblia Kinase, CMGC CLK 0.0075 0.0414 0.0324
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0079 0.0439 0.0432
Leishmania major protein kinase, putative 0.0022 0.005 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0037 0.0148 0.0148
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0413 0.0413
Leishmania major protein kinase, putative 0.0075 0.0414 0.0413
Echinococcus multilocularis smad 0.0034 0.0128 0.0128
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0002 0.0002
Trichomonas vaginalis esterase, putative 0.0038 0.0158 0.0163
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0017 0.0017
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0158
Plasmodium falciparum hexokinase 0.1467 1 1
Brugia malayi intermediate filament protein 0.0033 0.0121 0.0121
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0339 0.0339
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.006 0.006
Schistosoma mansoni smad1 5 8 and 0.0034 0.0128 0.0128
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0126 0.0767 0.0765
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0038 0.0158 0.0158
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0043 0.0191 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0339 0.0339
Schistosoma mansoni caspase-7 (C14 family) 0.0079 0.0439 0.0439
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.006 0.006
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0058 0.0058
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0877 0.0877
Echinococcus multilocularis 6 phosphogluconolactonase 0.0043 0.0191 0.0191
Onchocerca volvulus 0.0024 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.0225 0.0225
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0339 0.0339
Echinococcus granulosus hexokinase 0.1467 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0075 0.0413 0.0413
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1039 0.7054 0.7341
Trypanosoma brucei Metacaspase-4 0.0079 0.0439 0.0432
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0064 0.0335 0.0333
Echinococcus granulosus lamin dm0 0.0033 0.0121 0.0121
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0043 0.0191 0.019
Echinococcus granulosus citrate lyase subunit beta protein 0.0126 0.0767 0.0767
Mycobacterium ulcerans hypothetical protein 0.0126 0.0767 0.0743
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0414 0.0414
Echinococcus multilocularis caspase 8 0.0079 0.0439 0.0439
Onchocerca volvulus 0.092 0.6235 0.6235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0551 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0439 0.0455
Schistosoma mansoni smad1 5 8 and 0.0034 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0439 0.0455
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0225 0.0219
Echinococcus granulosus hexokinase 0.1467 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0225 0.0225
Onchocerca volvulus 0.1467 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0225 0.0233
Trypanosoma cruzi metacaspase, putative 0.0079 0.0439 0.0437
Leishmania major hexokinase, putative 0.1467 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0013 0.0013
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.006 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0264 0.0264
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0126 0.0767 0.0743
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0079 0.0439 0.0432
Onchocerca volvulus 0.0043 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.006
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.1039 0.7054 0.7052
Trichomonas vaginalis CAMK family protein kinase 0.0242 0.1565 0.1628
Entamoeba histolytica hexokinase 2 0.1467 1 1
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.1039 0.7054 0.7341
Brugia malayi hypoxia-induced factor 1 0.0182 0.1148 0.1148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0013 0.0013
Schistosoma mansoni lamin 0.0033 0.0121 0.0121
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0079 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.0117
Schistosoma mansoni Smad4 0.0034 0.0128 0.0128
Echinococcus multilocularis lamin 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0158 0.0668
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0043 0.0191 0.019
Echinococcus granulosus hexokinase 0.1467 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0439 0.0455
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0997 0.6759 0.6758
Trypanosoma brucei metacaspase 5, putative 0.0079 0.0439 0.0432
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0158 0.0668
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0126 0.0767 0.0765
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0997 0.6759 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Entamoeba histolytica hypothetical protein 0.0075 0.0413 0.0226
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0551 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0439 0.0455
Trypanosoma brucei beta lactamase 0.0129 0.0786 0.078
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0058 0.0056
Loa Loa (eye worm) nuclear factor I 0.0019 0.0025 0.0025
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0128 0.0128
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0129 0.0786 1
Schistosoma mansoni single-minded 0.0059 0.0301 0.0301
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.033 0.217 0.2169
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0269 0.175 0.7678
Echinococcus multilocularis hexokinase 0.1467 1 1
Schistosoma mansoni caspase-3 (C14 family) 0.0295 0.1925 0.1925
Onchocerca volvulus Serine\/threonine kinase homolog 0.0488 0.326 0.326
Mycobacterium ulcerans hypothetical protein 0.0038 0.0158 0.0106
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0269 0.175 0.1772
Brugia malayi Smad1 0.0034 0.0128 0.0128
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0225 0.0225
Schistosoma mansoni hypothetical protein 0.0024 0.006 0.006
Echinococcus granulosus dual specificity protein kinase clk2 0.0075 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0158
Loa Loa (eye worm) transcription factor SMAD2 0.0494 0.3298 0.3298
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.1039 0.7054 1
Leishmania major hexokinase, putative 0.1467 1 1
Echinococcus multilocularis caspase 3 0.0216 0.1383 0.1383
Giardia lamblia Kinase, PLK 0.0488 0.326 0.4472
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0997 0.6759 0.6759
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0064 0.0335 0.0333
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.006 0.006
Echinococcus multilocularis mitogen activated protein kinase 3 0.0064 0.0335 0.0335
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0114 0.0114
Brugia malayi Cytochrome P450 family protein 0.0023 0.0058 0.0058
Mycobacterium ulcerans lipoprotein LpqF 0.0129 0.0786 0.0763
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0358 0.0358
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0335 0.0347
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0126 0.0767 0.0765
Brugia malayi Cell death protein 3 precursor 0.0079 0.0439 0.0439
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Mycobacterium tuberculosis Conserved protein 0.0126 0.0767 0.3348
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0013 0.0013
Trypanosoma cruzi metacaspase, putative 0.0079 0.0439 0.0437
Echinococcus multilocularis GPCR, family 2 0.0017 0.0013 0.0013
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0225 0.0224
Toxoplasma gondii ABC1 family protein 0.0038 0.0158 0.0152
Schistosoma mansoni polycystin 1-related 0.0024 0.006 0.006
Schistosoma mansoni rab6-interacting 0.0024 0.006 0.006
Onchocerca volvulus Hexokinase homolog 0.092 0.6235 0.6235
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0079 0.0439 0.0439
Trichomonas vaginalis glutaminase, putative 0.141 0.9609 1
Trichomonas vaginalis CAMK family protein kinase 0.0242 0.1565 0.1628
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0064 0.0335 0.0333
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0997 0.6759 0.6757
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0158 0.0163
Plasmodium falciparum metacaspase 1 0.0079 0.0439 0.0432
Loa Loa (eye worm) hypothetical protein 0.0198 0.1263 0.1263
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0158 0.0158
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0148 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0339 0.0339
Mycobacterium tuberculosis Conserved protein 0.0038 0.0158 0.0668
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.006
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0043 0.0191 0.0185
Trypanosoma brucei metacaspase MCA2 0.0079 0.0439 0.0432
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0488 0.326 0.326
Loa Loa (eye worm) hypothetical protein 0.0466 0.3109 0.3109
Brugia malayi MH1 domain containing protein 0.0034 0.0128 0.0128
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0308 0.0302
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0079 0.0439 0.0455
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0877 0.0877
Mycobacterium tuberculosis Conserved protein 0.0038 0.0158 0.0668
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1039 0.7054 0.7341
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.006 0.0054
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.1148 0.1148
Trypanosoma brucei hypothetical protein, conserved 0.1098 0.7455 0.7453
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0075 0.0414 0.0414
Schistosoma mansoni 6-phosphogluconolactonase 0.0043 0.0191 0.0191
Trypanosoma cruzi hexokinase, putative 0.1467 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0158 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0158 0.0163
Brugia malayi MH1 domain containing protein 0.0019 0.0025 0.0025
Echinococcus multilocularis hexokinase 0.1467 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0158 0.0668
Schistosoma mansoni cpg binding protein 0.0033 0.0126 0.0126
Echinococcus multilocularis caspase 0.0295 0.1925 0.1925
Brugia malayi beta-lactamase 0.0038 0.0158 0.0158
Brugia malayi Protein kinase domain containing protein 0.0075 0.0414 0.0414
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0158 0.0158
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0143 0.0143
Trypanosoma brucei polo-like protein kinase 0.0488 0.326 0.3256
Echinococcus granulosus GPCR family 2 0.0017 0.0013 0.0013
Brugia malayi Hexokinase family protein 0.1467 1 1
Plasmodium vivax hexokinase, putative 0.1467 1 1
Echinococcus granulosus caspase 3 0.0216 0.1383 0.1383
Mycobacterium ulcerans hypothetical protein 0.0126 0.0767 0.0743
Onchocerca volvulus 0.0038 0.0158 0.0158
Plasmodium falciparum metacaspase-like protein 0.0079 0.0439 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0488 0.326 0.3392
Onchocerca volvulus 0.0032 0.0114 0.0114
Brugia malayi glutaminase DH11.1 0.141 0.9609 0.9609
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) beta-lactamase 0.0038 0.0158 0.0158
Loa Loa (eye worm) Smad1 0.0034 0.0128 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0339 0.0339
Trypanosoma brucei hexokinase, putative 0.1467 1 1
Onchocerca volvulus Cell death protein 3 homolog 0.0079 0.0439 0.0439
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.1822 0.1822
Echinococcus granulosus mitogen activated protein kinase 0.0064 0.0335 0.0335
Schistosoma mansoni 6-phosphogluconolactonase 0.0043 0.0191 0.0191
Brugia malayi Cytochrome P450 family protein 0.0036 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.0121 0.0121
Echinococcus multilocularis hexokinase type 2 0.1467 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0017 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0158 0.0158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0551 0.0551
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0997 0.6759 0.6759
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0488 0.326 0.3392
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0043 0.0191 0.019
Echinococcus multilocularis dual specificity protein kinase clk2 0.0075 0.0414 0.0414

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.584893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.981071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-FP Assay). (Class of assay: confirmatory) [Related pubchem assays: 1771, 1770 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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