Detailed information for compound 1315664

Basic information

Technical information
  • TDR Targets ID: 1315664
  • Name: N-[(E)-1-(3,4-dimethoxyphenyl)-3-(furan-2-ylm ethylamino)-3-oxoprop-1-en-2-yl]thiophene-2-c arboxamide
  • MW: 412.459 | Formula: C21H20N2O5S
  • H donors: 2 H acceptors: 2 LogP: 3.22 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)/C=C(\C(=O)NCc1ccco1)/NC(=O)c1cccs1
  • InChi: 1S/C21H20N2O5S/c1-26-17-8-7-14(12-18(17)27-2)11-16(23-21(25)19-6-4-10-29-19)20(24)22-13-15-5-3-9-28-15/h3-12H,13H2,1-2H3,(H,22,24)(H,23,25)/b16-11+
  • InChiKey: XJLXVDMYIYRPOD-LFIBNONCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-(3,4-dimethoxyphenyl)-3-(furan-2-ylmethylamino)-3-oxoprop-1-en-2-yl]thiophene-2-carboxamide
  • N-[(E)-2-(3,4-dimethoxyphenyl)-1-(2-furylmethylcarbamoyl)vinyl]thiophene-2-carboxamide
  • N-[2-(3,4-dimethoxyphenyl)-1-(2-furylmethylcarbamoyl)vinyl]thiophene-2-carboxamide
  • N-[(E)-2-(3,4-dimethoxyphenyl)-1-[(2-furylmethylamino)-oxomethyl]vinyl]-2-thiophenecarboxamide
  • N-[2-(3,4-dimethoxyphenyl)-1-[(2-furylmethylamino)-oxomethyl]vinyl]-2-thiophenecarboxamide
  • N-[(E)-1-(3,4-dimethoxyphenyl)-3-(furan-2-ylmethylamino)-3-oxo-prop-1-en-2-yl]thiophene-2-carboxamide
  • N-[1-(3,4-dimethoxyphenyl)-3-(furan-2-ylmethylamino)-3-oxo-prop-1-en-2-yl]thiophene-2-carboxamide
  • ZINC00904765
  • BAS 03273521
  • MLS000712767
  • SMR000282534

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0005
Echinococcus multilocularis protein dispatched 1 0.0048 0.0055 0.0127
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0093 0.0134 0.0781
Plasmodium falciparum metacaspase-like protein 0.0027 0.0017 0.0059
Loa Loa (eye worm) hypothetical protein 0.0039 0.0038 0.0225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0012 0.0573
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0069
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0094
Echinococcus multilocularis caspase 8 0.0027 0.0017 0.0038
Echinococcus granulosus protein kinase shaggy 0.0978 0.1708 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0133
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0192 0.1122
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.0795 0.4656
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0597 0.103 0.1419
Trypanosoma brucei protein kinase, putative 0.0978 0.1708 0.6302
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0038 0.0221
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0039 0.0038 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0192 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.004
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0001 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0978 0.1708 1
Loa Loa (eye worm) hypothetical protein 0.018 0.029 0.1698
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.001 0.0469
Entamoeba histolytica protein kinase, putative 0.0065 0.0085 0.0495
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0392 0.2293
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0017 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0017 0.0059
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.001 0.0057
Echinococcus multilocularis muscleblind protein 0.018 0.029 0.0661
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Trypanosoma cruzi hypothetical protein 0.0093 0.0134 0.0492
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0017 0.0098
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.004
Echinococcus granulosus expressed conserved protein 0.0093 0.0134 0.0788
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0012 0.0562
Entamoeba histolytica protein kinase, putative 0.0065 0.0085 0.0495
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0065 0.0085 0.0195
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0038 0.0139
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0001 0.0005
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0085 0.0499
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.001 0.5
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0078 0.0108 0.0245
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0192 0.0704
Brugia malayi Pre-SET motif family protein 0.003 0.0023 0.0031
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0038 0.0221
Echinococcus granulosus sentrin specific protease 8 0.0093 0.0134 0.0785
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0108 0.0394
Echinococcus granulosus caspase 0.01 0.0147 0.0859
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0048 0.028
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0001 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.112
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.02 0.0324 0.1899
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0978 0.1708 1
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0059
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0145 0.0846
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0023 0.0133
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0085 0.0499
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0001 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0012 0.0562
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.001 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0005
Leishmania major protein kinase, putative 0.0065 0.0085 0.0312
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0038 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0005
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0038 0.0053
Onchocerca volvulus 0.0484 0.083 0.0829
Echinococcus multilocularis Ankyrin 0.0032 0.0026 0.0059
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0012 0.0064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0208
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0039 0.0038 1
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0145 0.085
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0579 0.0999 0.5847
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0023 0.0081
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0026 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0562
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.021 0.0343 0.2009
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.112
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.001 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.001 0.0022
Brugia malayi serine/threonine protein kinase 6 0.0065 0.0085 0.0117
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0001 0.0005
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0038 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0085 0.0499
Schistosoma mansoni ap endonuclease 0.0023 0.001 0.0057
Echinococcus granulosus death domain containing protein 0.0032 0.0026 0.0151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0039 0.023
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0085 0.0495
Giardia lamblia Sentrin specific protease, putative 0.0039 0.0038 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.0016
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0001 0.0005
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0597 0.103 0.3801
Echinococcus multilocularis sentrin specific protease 1 0.0039 0.0038 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0023 0.0133
Onchocerca volvulus Huntingtin homolog 0.0134 0.0207 0.0207
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0017 0.0023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0023 0.0052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.001 0.0458
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0069
Echinococcus multilocularis Zinc finger, PHD finger 0.0078 0.0108 0.0245
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0021 0.0121
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.001 0.0033
Echinococcus granulosus caspase 8 0.0027 0.0017 0.0098
Trypanosoma brucei telomerase reverse transcriptase 0.1542 0.2709 1
Echinococcus multilocularis aurora kinase A 0.0065 0.0085 0.0195
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0085 0.0495
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0018 0.0001 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0078 0.0108 0.0394
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.0225
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0017 0.0059
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0978 0.1708 0.6302
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0085 0.0495
Echinococcus granulosus neuropeptide s receptor 0.0465 0.0795 0.4656
Schistosoma mansoni survival motor neuron protein 0.0048 0.0055 0.0325
Brugia malayi hypothetical protein 0.003 0.0023 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0192 0.1122
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0059
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0012 0.0064
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0387 0.0656 0.1497
Brugia malayi Uncoordinated protein 44 0.0032 0.0026 0.0036
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0108 0.0626
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0045 0.0262
Brugia malayi hypothetical protein 0.0238 0.0392 0.0539
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0001 0.0002
Giardia lamblia Kinase, CMGC GSK 0.0978 0.1708 0.6302
Loa Loa (eye worm) hypothetical protein 0.0039 0.0038 0.0225
Loa Loa (eye worm) hypothetical protein 0.018 0.029 0.1698
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0023 0.0084
Echinococcus multilocularis protein patched 0.0042 0.0045 0.0102
Onchocerca volvulus 0.0024 0.0012 0.0011
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0017 0.0016
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0012 0.0064
Schistosoma mansoni hypothetical protein 0.0039 0.0039 0.023
Schistosoma mansoni hypothetical protein 0.0041 0.0042 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0562
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0023 0.0052
Echinococcus multilocularis protein kinase shaggy 0.0978 0.1708 0.3895
Plasmodium falciparum glycogen synthase kinase 3 0.0978 0.1708 0.6302
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0192 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0094
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0005
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0065 0.0085 0.0495
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0026 0.0151
Trypanosoma brucei metacaspase MCA3 0.0027 0.0017 0.0059
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0012 0.0573
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0018 0.0001 0.0005
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0026 0.0151
Loa Loa (eye worm) phosphatidylinositol kinase 0.0018 0.0001 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.001 0.0033
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.014 0.0217 0.08
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0108 0.0394
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0001 0.0002
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.01 0.0147 0.0334
Trypanosoma cruzi aurora B kinase, putative 0.0065 0.0085 0.0312
Plasmodium vivax SET domain protein, putative 0.003 0.0023 0.0081
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0137
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0191 0.0263
Leishmania major phosphatidylinositol 3-kinase, putative 0.0078 0.0108 0.0394
Echinococcus multilocularis muscleblind protein 1 0.018 0.029 0.0661
Giardia lamblia Aurora kinase 0.0065 0.0085 0.0312
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0311 0.0522 0.119
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0085 0.0499
Loa Loa (eye worm) hypothetical protein 0.0484 0.083 0.4858
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0039 0.0038 0.0139
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0174 0.0279 0.1635
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0023 0.0084
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0026 0.0151
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0078 0.0108 0.063
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0005
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0039 0.0038 0.0139
Leishmania major metacaspase, putative 0.0027 0.0017 0.0059
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0597 0.103 0.235
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0108 0.0394
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0078 0.0108 0.0626
Brugia malayi Muscleblind-like protein 0.018 0.029 0.0399
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0001 0.0012
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0039 0.0038 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0001 0.0005
Brugia malayi Death domain containing protein 0.0032 0.0026 0.0036
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0191 0.0436
Trypanosoma brucei aurora B kinase 0.0065 0.0085 0.0312
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0018 0.0001 0.0005
Entamoeba histolytica protein kinase, putative 0.0978 0.1708 1
Brugia malayi serine/threonine kinase 12 0.0065 0.0085 0.0117
Echinococcus multilocularis sentrin specific protease 8 0.0093 0.0134 0.0306
Plasmodium vivax sentrin-specific protease 1, putative 0.0039 0.0038 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0048 0.028
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0017 0.0059
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0362
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Loa Loa (eye worm) RNA binding protein 0.0125 0.0191 0.112
Trichomonas vaginalis CMGC family protein kinase 0.0978 0.1708 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0023 0.0133
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0001 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0191 0.112
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0562
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0978 0.1708 0.6302
Schistosoma mansoni hypothetical protein 0.0032 0.0026 0.0151
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0192 0.0704
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0065 0.0085 0.0499
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0597 0.103 0.6031
Brugia malayi hypothetical protein 0.0484 0.083 0.1143
Entamoeba histolytica protein kinase domain containing protein 0.0978 0.1708 1
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0221 0.1292
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0039 0.0038 0.0139
Leishmania major telomerase reverse transcriptase, putative 0.1542 0.2709 1
Schistosoma mansoni ap endonuclease 0.0023 0.001 0.0057
Leishmania major hypothetical protein, conserved 0.003 0.0023 0.0084
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.0145 0.085
Plasmodium falciparum telomerase reverse transcriptase 0.1542 0.2709 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0039 0.009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0001 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0066 0.0091
Echinococcus granulosus caspase 2 0.0027 0.0017 0.0098
Echinococcus multilocularis caspase 0.01 0.0147 0.0334
Echinococcus granulosus nuclear factor of activated T cells 5 0.0311 0.0522 0.3055
Trichomonas vaginalis CMGC family protein kinase 0.0978 0.1708 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0078 0.0108 0.063
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0078 0.0108 0.063
Onchocerca volvulus 0.0039 0.0038 0.0038
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0038 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.112
Loa Loa (eye worm) hypothetical protein 0.0134 0.0207 0.1214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0001 0.0001
Schistosoma mansoni lozenge 0.0061 0.0077 0.0453
Brugia malayi Protein kinase domain containing protein 0.0042 0.0043 0.006
Echinococcus multilocularis caspase 2 0.0027 0.0017 0.0038
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.0225
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0108 0.0394
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0387 0.0656 0.0904
Echinococcus multilocularis sentrin specific protease 7 0.0174 0.0279 0.0637
Entamoeba histolytica hypothetical protein 0.0475 0.0814 0.4762
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0018 0.0001 0.0002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0182 0.0293 0.1078
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.001 0.0033
Plasmodium vivax sentrin-specific protease 2, putative 0.0039 0.0038 0.0139
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1542 0.2709 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.0225
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0597 0.103 0.3801
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0597 0.103 0.6033
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0018 0.0001 0.0002
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0038 0.0221
Plasmodium vivax glycogen synthase kinase 3, putative 0.0978 0.1708 0.6302
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0066 0.0091
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.02 0.0324 0.1895
Echinococcus granulosus muscleblind protein 0.018 0.029 0.1698
Giardia lamblia Kinase, CMGC GSK 0.0978 0.1708 0.6302
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0078 0.0108 0.0394
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0039 0.0038 0.0221
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0814 0.4764
Echinococcus granulosus caspase 3 0.0073 0.0099 0.0581
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.02 0.0324 0.1895
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0018 0.0001 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0066 0.0388
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0151
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Schistosoma mansoni caspase-3 (C14 family) 0.01 0.0147 0.0859
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0038 0.0053
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0001 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0192 0.0437
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0045 0.0258
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0026 0.0151
Echinococcus multilocularis caspase 3 0.0073 0.0099 0.0226
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0192 0.1122
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0094
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0023 0.0084
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0045 0.0262
Onchocerca volvulus 0.0238 0.0393 0.0392
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0048 0.0109
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0017 0.0098
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0001 0.0002
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0078 0.0108 0.0148
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.0814 0.4762
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0038 0.0221
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0341 0.1997
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0012 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.02 0.0324 0.1194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0048 0.028
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.001 0.0052
Echinococcus granulosus aurora kinase A 0.0065 0.0085 0.0499
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0978 0.1708 0.6302
Loa Loa (eye worm) runx1 0.0061 0.0077 0.0453
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0238 0.0392 0.2293
Schistosoma mansoni patched 1 0.0042 0.0045 0.0262
Echinococcus multilocularis expressed conserved protein 0.0093 0.0134 0.0307
Loa Loa (eye worm) hypothetical protein 0.0039 0.0038 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0094
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0012 0.0562
Onchocerca volvulus Huntingtin homolog 0.0134 0.0207 0.0207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.02 0.0324 0.0447
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0018 0.0001 0.0005
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0023 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Trypanosoma brucei Metacaspase-4 0.0027 0.0017 0.0059
Plasmodium vivax telomerase reverse transcriptase, putative 0.1542 0.2709 1
Plasmodium falciparum sentrin-specific protease 1 0.0039 0.0038 0.0139
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0018 0.0001 0.0002
Onchocerca volvulus 0.003 0.0023 0.0022
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.041 0.0698 0.4085
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0221 0.0503
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0023 0.0084
Trypanosoma brucei metacaspase 0.0027 0.0017 0.0059
Echinococcus multilocularis 0.0018 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0066 0.0388
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.001 0.0033
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0093 0.0134 0.0781
Onchocerca volvulus 0.0978 0.1708 0.1707
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0108 0.063
Giardia lamblia Telomerase catalytic subunit 0.1542 0.2709 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0045 0.0262
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0093 0.0134 0.0185
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0387 0.0656 0.3844
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.01 0.0147 0.0859
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0978 0.1708 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0038 0.0221
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0093 0.0134 0.0785
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0017 0.0059
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0288 0.0481 0.1774
Schistosoma mansoni netrin receptor unc5 0.0032 0.0026 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.112
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0023 0.0084
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0045 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0023 0.0084
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0078 0.0108 0.0626
Schistosoma mansoni hypothetical protein 0.0041 0.0042 0.0246
Brugia malayi serine/threonine-protein kinase 6 0.0065 0.0085 0.0117
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1542 0.2709 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0065 0.0085 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0048 0.028
Loa Loa (eye worm) hypothetical protein 0.0042 0.0045 0.0262
Loa Loa (eye worm) hypothetical protein 0.0387 0.0656 0.3844
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0098
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0023 0.0133
Echinococcus granulosus sentrin specific protease 1 0.0039 0.0038 0.0225
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0108 0.0394
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0145 0.02
Toxoplasma gondii RNA-directed DNA polymerase 0.1542 0.2709 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.001 0.0033
Echinococcus granulosus expressed conserved protein 0.0135 0.021 0.123
Echinococcus granulosus Ankyrin 0.0032 0.0026 0.0153
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0108 0.0626
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0078 0.0108 0.0626
Brugia malayi Cell death protein 3 precursor 0.0027 0.0017 0.0023
Echinococcus granulosus sentrin specific protease 7 0.0174 0.0279 0.1635
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0039 0.023
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0001 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0048 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0048 0.028
Schistosoma mansoni caspase-7 (C14 family) 0.01 0.0147 0.0859
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0192 1
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.0225
Schistosoma mansoni hypothetical protein 0.0048 0.0055 0.0325
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.001 0.0052
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0065 0.0085 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0191 0.112
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0597 0.103 0.6033
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0065 0.0085 0.0495
Loa Loa (eye worm) Ulp1 protease 0.0039 0.0038 0.0225
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.0016
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0005
Echinococcus granulosus tar DNA binding protein 0.0125 0.0191 0.112
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0392 0.2294
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0001 0.0001
Brugia malayi intracellular kinase 0.0978 0.1708 0.2352
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0597 0.103 0.6031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.0795 0.1813
Plasmodium vivax metacaspase 1, putative 0.0027 0.0017 0.0059
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0055 0.0076
Toxoplasma gondii exonuclease III APE 0.0023 0.001 0.0033
Brugia malayi RNA binding protein 0.0125 0.0191 0.0263
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0012 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0191 0.112
Schistosoma mansoni hypothetical protein 0.0037 0.0036 0.0208
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.02 0.0324 0.1895
Brugia malayi CHE-14 protein 0.0042 0.0045 0.0062
Schistosoma mansoni hypothetical protein 0.0041 0.0042 0.0246
Plasmodium falciparum metacaspase 1 0.0027 0.0017 0.0059
Brugia malayi hypothetical protein 0.0134 0.0207 0.0286
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0026 0.0153
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0038 0.0221
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0392 0.0893
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0059
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0085 0.0495
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0978 0.1708 0.3895
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0039 0.0038 0.0225
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0026 0.0059
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0018 0.0001 0.0005
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0017 0.0059
Onchocerca volvulus 0.0048 0.0055 0.0055
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0038 0.0139
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0085 0.0495
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0174 0.0279 0.1631
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0038 0.0221
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0597 0.103 0.6031
Plasmodium falciparum serine/threonine protein kinase, putative 0.0065 0.0085 0.0312
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.0795 0.1813
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0597 0.103 0.6031
Loa Loa (eye worm) hypothetical protein 0.0484 0.083 0.4858
Brugia malayi Pre-SET motif family protein 0.0209 0.0341 0.047
Echinococcus multilocularis expressed conserved protein 0.0135 0.021 0.0479
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.02 0.0324 0.1895
Loa Loa (eye worm) hypothetical protein 0.0134 0.0207 0.1214
Echinococcus multilocularis Protein lozenge 0.0061 0.0077 0.0176
Brugia malayi hypothetical protein 0.0039 0.0039 0.0054
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0265 0.044 0.2572
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0978 0.1708 1
Schistosoma mansoni protein kinase 0.0065 0.0085 0.0499
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0093 0.0134 0.0781
Loa Loa (eye worm) Ulp1 protease 0.0093 0.0134 0.0785
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.001 0.0052
Brugia malayi TAR-binding protein 0.0125 0.0191 0.0263
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0018 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0098
Entamoeba histolytica protein kinase , putative 0.0065 0.0085 0.0495
Entamoeba histolytica protein kinase domain containing protein 0.0978 0.1708 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0023 0.0133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0048 0.028
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0012 0.0562
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.041 0.0698 0.4085
Brugia malayi hypothetical protein 0.002 0.0004 0.0006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.02 0.0324 0.1895
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0017 0.0059
Mycobacterium ulcerans hypothetical protein 0.0024 0.0012 0.0562
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2485 0.4384 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0036 0.0049
Brugia malayi Telomerase reverse transcriptase 0.4103 0.726 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0293 0.1715
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.02 0.0324 0.1194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0048 0.0109
Toxoplasma gondii aurora kinase 0.0065 0.0085 0.0312
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0005
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0108 0.0394
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.001 0.0057
Schistosoma mansoni hypothetical protein 0.0041 0.0042 0.0246
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0069
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0093 0.0134 0.0781
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0078 0.0108 0.063
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0039 0.0038 0.0139
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0038 0.0221
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.0016
Trypanosoma brucei SUMO1/Ulp2, putative 0.0039 0.0038 0.0139
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.001 0.0033
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0148 0.0866
Trichomonas vaginalis Sentrin-specific protease, putative 0.0093 0.0134 0.0781
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0038 0.0221
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0145 0.0331
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0005
Trypanosoma brucei metacaspase MCA2 0.0027 0.0017 0.0059

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3981 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5858 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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