Detailed information for compound 1317761

Basic information

Technical information
  • TDR Targets ID: 1317761
  • Name: 2-[(4-amino-6,7,8,9-tetrahydropyrimido[4,5-b] quinolin-2-yl)sulfanyl]-N-(4-methoxyphenyl)ac etamide
  • MW: 395.478 | Formula: C20H21N5O2S
  • H donors: 2 H acceptors: 4 LogP: 3.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CSc1nc(N)c2c(n1)nc1c(c2)CCCC1
  • InChi: 1S/C20H21N5O2S/c1-27-14-8-6-13(7-9-14)22-17(26)11-28-20-24-18(21)15-10-12-4-2-3-5-16(12)23-19(15)25-20/h6-10H,2-5,11H2,1H3,(H,22,26)(H2,21,23,24,25)
  • InChiKey: YVLYNLNFGUDAAZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(4-amino-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-2-yl)thio]-N-(4-methoxyphenyl)acetamide
  • 2-[(4-amino-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-2-yl)sulfanyl]-N-(4-methoxyphenyl)ethanamide
  • 2-(4-Amino-6,7,8,9-tetrahydro-pyrimido[4,5-b]quinolin-2-ylsulfanyl)-N-(4-methoxy-phenyl)-acetamide
  • MLS000589159
  • SMR000219792
  • STOCK4S-17668
  • ZINC02368888

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0349 0.0354
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0356 0.4098
Echinococcus granulosus lamin 0.0054 0.0435 0.0441
Loa Loa (eye worm) hypothetical protein 0.0047 0.0349 0.1219
Schistosoma mansoni glucose transporter 0.0029 0.0151 0.0153
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0356 0.0361
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0337 0.3692 0.5495
Plasmodium vivax sugar transporter, putative 0.0029 0.0151 0.0092
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0151 0.0153
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0558 0.8107
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0658 0.0667
Loa Loa (eye worm) sugar transporter 0.0029 0.0151 0.0527
Plasmodium vivax CDK-related protein kinase 6, putative 0.0884 1 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0549 0.0492
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0421 0.042
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2213 0.2244
Onchocerca volvulus 0.0054 0.0435 0.2138
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0151 0.0149
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0349 0.4836
Plasmodium falciparum mitogen-activated protein kinase 2 0.0337 0.3692 0.3654
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0349 0.0961
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0068 0.0274
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0221 0.0224
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2213 0.2244
Schistosoma mansoni hypothetical protein 0.0178 0.1862 0.1888
Schistosoma mansoni intermediate filament proteins 0.0054 0.0435 0.0441
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0151 0.0527
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0349 0.395
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0143 0.1394
Loa Loa (eye worm) hypothetical protein 0.0178 0.1862 0.6507
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.015 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0864 0.0875
Entamoeba histolytica hypothetical protein 0.0036 0.0223 0.198
Schistosoma mansoni hypothetical protein 0.0082 0.0762 0.0772
Onchocerca volvulus 0.0029 0.0151 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0864 0.3017
Mycobacterium ulcerans sugar transporter 0.0029 0.0151 0.1522
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0548 0.0556
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0349 0.0291
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0151 0.1709
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.2862 0.2901
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0549 0.0618
Echinococcus multilocularis solute carrier family 22 0.0029 0.0151 0.0153
Echinococcus multilocularis lamin 0.0054 0.0435 0.0441
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0548 0.0556
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0548 0.0556
Echinococcus multilocularis solute carrier family 22 0.0029 0.0151 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0143 0.05
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0151 0.5
Schistosoma mansoni lamin 0.0054 0.0435 0.0441
Toxoplasma gondii sugar transporter ST2 0.0029 0.0151 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0421 0.5387
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Loa Loa (eye worm) hypothetical protein 0.0053 0.0421 0.1471
Echinococcus multilocularis tumor protein p63 0.0723 0.8142 0.8254
Toxoplasma gondii sugar transporter ST3 0.0029 0.0151 0.0001
Schistosoma mansoni hypothetical protein 0.0082 0.0762 0.0772
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0533 0.1863
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0151 0.0527
Schistosoma mansoni hypothetical protein 0.0036 0.0223 0.0226
Echinococcus granulosus intermediate filament protein 0.0054 0.0435 0.0441
Schistosoma mansoni hypothetical protein 0.0208 0.2213 0.2244
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0356 0.0361
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0282 0.0286
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0548 0.0556
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0533 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0864 0.0875
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0558 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2213 0.2244
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0208
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0068 0.5
Echinococcus multilocularis GPCR, family 2 0.0082 0.0762 0.0772
Brugia malayi intermediate filament protein 0.0054 0.0435 0.152
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Brugia malayi hypothetical protein 0.0034 0.0206 0.0719
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0549 0.0492
Schistosoma mansoni hypothetical protein 0.0082 0.0762 0.0772
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0762 0.2661
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0653 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0658 0.0667
Schistosoma mansoni hypothetical protein 0.0082 0.0762 0.0772
Echinococcus multilocularis solute carrier family 22 0.0029 0.0151 0.0153
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0533 0.0541
Brugia malayi Cam kinase protein 1 0.0064 0.0548 0.1915
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0421 0.5387
Schistosoma mansoni hypothetical protein 0.0024 0.0086 0.0087
Echinococcus multilocularis short transient receptor potential channel 6 0.0126 0.1259 0.1277
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0208
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0558 0.8107
Loa Loa (eye worm) hypothetical protein 0.0063 0.0533 0.1863
Trypanosoma cruzi hexose transporter, putative 0.0035 0.022 0.1383
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0533 0.1855
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.1862 0.6507
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0558 0.1973
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0146 0.0511
Echinococcus granulosus muscleblind protein 0.018 0.1891 0.1917
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0143 0.1394
Echinococcus granulosus transient receptor potential ion channel A 0.0183 0.1927 0.1953
Loa Loa (eye worm) hypothetical protein 0.0064 0.0553 0.1934
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0151 0.0153
Brugia malayi hypothetical protein 0.0029 0.0151 0.0527
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0558 0.1973
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0356 0.0298
Schistosoma mansoni hypothetical protein 0.0029 0.015 0.0152
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0658 1
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0509 0.178
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0151 0.0153
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0762 0.2661
Onchocerca volvulus 0.0106 0.1032 0.651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2213 0.2244
Echinococcus multilocularis geminin 0.0873 0.9865 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0143 0.1394
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0356 0.0361
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0533 1
Plasmodium vivax hexose transporter 0.0208 0.2213 0.2167
Entamoeba histolytica protein kinase, putative 0.0064 0.0548 1
Onchocerca volvulus 0.0029 0.0151 0.0056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0548 0.0556
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0337 0.3692 0.3654
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0548 0.0556
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0548 0.1915
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0558 0.1973
Loa Loa (eye worm) hypothetical protein 0.0029 0.0143 0.05
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0208
Leishmania major glucose transporter, lmgt1 0.0065 0.0558 0.8052
Echinococcus granulosus lamin dm0 0.0054 0.0435 0.0441
Onchocerca volvulus 0.0029 0.0151 0.0056
Brugia malayi MH2 domain containing protein 0.0238 0.2554 0.8925
Schistosoma mansoni sugar transporter 0.0029 0.0151 0.0153
Onchocerca volvulus 0.0054 0.0435 0.2138
Schistosoma mansoni sugar transporter 0.0029 0.0151 0.0153
Brugia malayi Bromodomain containing protein 0.0029 0.015 0.0525
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0558 0.1973
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.015 0.0525
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0421 0.0364
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0151 0.1522
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.015 0.0152
Giardia lamblia Hexose transporter 0.0029 0.0151 0.0009
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0548 0.1915
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0283 0.0641
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Schistosoma mansoni sugar transporter 0.0029 0.0151 0.0153
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0917 0.093
Plasmodium falciparum hexose transporter 0.0208 0.2213 0.2167
Loa Loa (eye worm) hypothetical protein 0.0063 0.0533 0.1863
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0349 0.0308
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0558 0.1973
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0151 0.0527
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0864 0.3017
Echinococcus granulosus solute carrier family 22 0.0029 0.0151 0.0153
Schistosoma mansoni hypothetical protein 0.0873 0.9865 1
Loa Loa (eye worm) hypothetical protein 0.026 0.281 0.982
Entamoeba histolytica hypothetical protein 0.0036 0.0223 0.198
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0151 0.0001
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0558 0.8107
Giardia lamblia Sugar-proton symporter 0.0029 0.0151 0.0009
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0268 0.3629
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0143 0.1394
Entamoeba histolytica hypothetical protein 0.0036 0.0223 0.198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0864 0.0875
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0421 0.0364
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0356 0.032
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0549 0.0492
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0917 0.093
Echinococcus granulosus geminin 0.0873 0.9865 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.015 0.0091
Schistosoma mansoni hypothetical protein 0.0054 0.0435 0.0441
Schistosoma mansoni glucose transport protein 0.0208 0.2213 0.2244
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0762 0.0772
Echinococcus multilocularis muscleblind protein 1 0.018 0.1891 0.1917
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0548 0.0556
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0435 0.152
Brugia malayi Sugar transporter family protein 0.0029 0.0151 0.0527
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0548 0.1927
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0762 0.0772
Brugia malayi Sugar transporter family protein 0.0029 0.0151 0.0527
Brugia malayi hypothetical protein 0.0036 0.0223 0.078
Brugia malayi Sugar transporter family protein 0.0208 0.2213 0.7734
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0349 0.5186
Brugia malayi Transient-receptor-potential like protein 0.0071 0.0626 0.2189
Leishmania major glucose transporter, lmgt2 0.0065 0.0558 0.8052
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0208
Toxoplasma gondii sugar transporter ST1 0.0029 0.0151 0.0001
Onchocerca volvulus 0.0029 0.0151 0.0056
Onchocerca volvulus 0.0147 0.1509 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2213 0.2244
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2213 0.2244
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0221 0.0224
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0208 0.2213 0.2244
Loa Loa (eye worm) hypothetical protein 0.0053 0.0424 0.1481
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0356 0.4098
Trypanosoma brucei glucose transporter 2A 0.0065 0.0558 0.8107
Onchocerca volvulus 0.0029 0.0151 0.0056
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.015 0.0152
Brugia malayi jmjC domain containing protein 0.0035 0.0221 0.0773
Trypanosoma cruzi hexose transporter 0.0065 0.0558 0.8107
Echinococcus multilocularis peregrin 0.0029 0.015 0.0152
Entamoeba histolytica hypothetical protein 0.0047 0.0349 0.5083
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0658 1
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.1032 0.1046
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0503 0.051
Loa Loa (eye worm) hypothetical protein 0.0147 0.1509 0.5273
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0533 0.9633
Loa Loa (eye worm) hypothetical protein 0.0054 0.0435 0.152
Echinococcus granulosus transient receptor potential gamma protein 0.019 0.2 0.2027
Loa Loa (eye worm) hypothetical protein 0.0071 0.0626 0.2189
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0349 0.5277
Plasmodium falciparum phd finger protein, putative 0.0029 0.015 0.0091
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0151 0.0527
Entamoeba histolytica hypothetical protein 0.0036 0.0223 0.198
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0349 1
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2213 1
Brugia malayi PHD-finger family protein 0.0029 0.015 0.0525
Schistosoma mansoni transient receptor potential channel 4 0.019 0.2 0.2027
Loa Loa (eye worm) hypothetical protein 0.018 0.1891 0.6608
Onchocerca volvulus 0.0029 0.0151 0.0056
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0653 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1891 0.6608
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0533 1
Schistosoma mansoni survival motor neuron protein 0.0054 0.0435 0.0441
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0864 0.0875
Leishmania major hypothetical protein, conserved 0.0053 0.0421 0.5401
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Loa Loa (eye worm) hypothetical protein 0.0064 0.0548 0.1915
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0356 0.0298
Onchocerca volvulus 0.0029 0.0151 0.0056
Entamoeba histolytica protein kinase, putative 0.0064 0.0548 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0549 0.0492
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0282 0.0286
Schistosoma mansoni protein kinase 0.0064 0.0548 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0558 0.1973
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0349 0.0354
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0356 0.4098
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0349 0.4836
Echinococcus multilocularis muscleblind protein 0.018 0.1891 0.1917
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0356 0.0361
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0549 0.0492
Echinococcus granulosus General substrate transporter 0.0179 0.1876 0.1901
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0221 0.0773
Onchocerca volvulus 0.0054 0.0435 0.2138
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0143 0.1394
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0268 0.3208
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0113 0.0115
Onchocerca volvulus 0.0029 0.0151 0.0056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0143 0.1583
Trypanosoma brucei glucose transporter 1E 0.0065 0.0558 0.8107
Brugia malayi hypothetical protein 0.0053 0.0421 0.1471
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0653 0.9898
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0356 0.4144
Onchocerca volvulus 0.0029 0.0151 0.0056
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Leishmania major glucose transporter, lmgt3 0.0065 0.0558 0.8052
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0558 0.8052
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0151 0.0527
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0143 0.1394
Loa Loa (eye worm) hypothetical protein 0.0082 0.0762 0.2661
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0549 0.0492
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0146 0.0511
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0658 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0221 0.0224
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0658 0.0788
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0109 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0864 0.0875
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.281 0.982
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0762 0.2661
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0549 0.0492
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0349 0.1219
Onchocerca volvulus 0.0029 0.0151 0.0056
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0658 0.0667
Onchocerca volvulus 0.0029 0.0151 0.0056
Echinococcus multilocularis musashi 0.0054 0.0435 0.0441
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0549 0.0492
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0421 0.0364
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0533 0.0541
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0068 0.0132
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0503 0.051
Leishmania major hypothetical protein, conserved 0.0029 0.0151 0.0149
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0435 0.152
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0356 0.0361
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0086 0.0087
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0653 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0548 0.0556
Mycobacterium ulcerans hypothetical protein 0.0029 0.0143 0.1394
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0151 0.0153
Echinococcus granulosus short transient receptor potential channel 6 0.0126 0.1259 0.1277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0396
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0356 0.1245
Schistosoma mansoni transient receptor potential channel 0.019 0.2 0.2027
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0548 0.0556
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0349 0.0354
Onchocerca volvulus 0.0029 0.0151 0.0056
Schistosoma mansoni lamin 0.0054 0.0435 0.0441
Echinococcus multilocularis lamin dm0 0.0054 0.0435 0.0441
Echinococcus multilocularis transient receptor potential gamma protein 0.019 0.2 0.2027
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0151 0.0092
Echinococcus multilocularis General substrate transporter 0.0179 0.1876 0.1901
Echinococcus multilocularis transient receptor potential ion channel A 0.0183 0.1927 0.1953
Schistosoma mansoni hypothetical protein 0.0873 0.9865 1
Plasmodium falciparum protein kinase 7 0.0589 0.6594 0.6574
Echinococcus granulosus solute carrier family 22 0.0029 0.0151 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0356 0.0361
Brugia malayi major facilitator superfamily protein 0.0029 0.0151 0.0527
Brugia malayi isocitrate dehydrogenase 0.0047 0.0356 0.1245
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0533 0.1863
Toxoplasma gondii facilitative glucose transporter GT1 0.0208 0.2213 0.3201
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0151 0.1709
Toxoplasma gondii protein kinase, putative 0.0589 0.6594 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.281 0.982
Echinococcus multilocularis solute carrier family 22 0.0029 0.0151 0.0153
Schistosoma mansoni glucose transport protein 0.0208 0.2213 0.2244
Echinococcus multilocularis short transient receptor potential channel 6 0.0126 0.1259 0.1277
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0549 0.0618
Onchocerca volvulus 0.0029 0.0151 0.0056
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0349 0.395
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0268 0.3629
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0421 0.5387
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2213 0.2244
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0143 0.05
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0558 0.8107
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0349 0.0291
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0143 0.1394
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0658 0.0667
Brugia malayi hypothetical protein 0.0265 0.2862 1
Echinococcus granulosus short transient receptor potential channel 6 0.0126 0.1259 0.1277
Echinococcus granulosus solute carrier family 22 0.0029 0.0151 0.0153
Schistosoma mansoni jumonji domain containing protein 0.0076 0.069 0.07
Brugia malayi hypothetical protein 0.0147 0.1509 0.5273
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0525
Leishmania major protein kinase, putative 0.0064 0.0548 0.7869
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0356 0.0361
Loa Loa (eye worm) hypothetical protein 0.0029 0.0143 0.05
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0208
Loa Loa (eye worm) hypothetical protein 0.0265 0.2862 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0391 0.1367
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0533 0.0541
Loa Loa (eye worm) hypothetical protein 0.0119 0.1186 0.4146
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0558 0.8107
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0151 0.1522
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0113 0.0115
Schistosoma mansoni protein kinase 0.0064 0.0548 0.0556
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0435 0.152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0864 0.0875
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0221 0.0224
Echinococcus granulosus TRP transient receptor potential channel 0.0071 0.0626 0.0635
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0356 0.032
Loa Loa (eye worm) hypothetical protein 0.0051 0.0398 0.1392
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0548 0.7919
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.2862 0.2901
Brugia malayi jmjC domain containing protein 0.0096 0.0917 0.3206
Schistosoma mansoni transient receptor potential channel 0.0126 0.1259 0.1277
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0086 0.0087
Onchocerca volvulus 0.0029 0.0151 0.0056
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0653 0.0597
Echinococcus granulosus solute carrier family 22 0.0029 0.0151 0.0153
Echinococcus granulosus peregrin 0.0029 0.015 0.0152
Loa Loa (eye worm) hypothetical protein 0.019 0.2 0.6987
Echinococcus granulosus tumor protein p63 0.0723 0.8142 0.8254
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0356 0.4098
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0549 0.0492
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0356 0.5071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0356
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0223 0.0226
Trypanosoma brucei glucose transporter, putative 0.0065 0.0558 0.8107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0658 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.006 0.022
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0349 0.4
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0143 0.05
Schistosoma mansoni sugar transporter 0.0029 0.0151 0.0153
Schistosoma mansoni protein kinase 0.0064 0.0548 0.0556
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0356 0.1245
Onchocerca volvulus 0.0029 0.0151 0.0056
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2554 0.8925
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0223 0.0226
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0151 0.1522
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.281 0.982
Onchocerca volvulus 0.0029 0.0151 0.0056
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0071 0.0626 0.0635
Brugia malayi Muscleblind-like protein 0.018 0.1891 0.6608
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0548 0.1915
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0143 0.1583
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2554 0.8925
Brugia malayi hypothetical protein 0.0029 0.0151 0.0527
Loa Loa (eye worm) hypothetical protein 0.0106 0.1032 0.3607
Onchocerca volvulus Putative transporter 0.0029 0.0151 0.0056
Brugia malayi hypothetical protein 0.0029 0.0151 0.0527
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0356
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0762 0.0772
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0762 0.0772
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0527
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0435 0.152
Schistosoma mansoni glucose transport protein 0.0208 0.2213 0.2244
Brugia malayi major facilitator superfamily protein 0.0029 0.0151 0.0527
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0223 0.0226
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0549 0.0618
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0349 0.0354
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0151 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0558 0.1973
Loa Loa (eye worm) sugar transporter 0.0208 0.2213 0.7734
Schistosoma mansoni transient receptor potential channel 0.0126 0.1259 0.1277
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0653 0.9898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0864 0.0875
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0658 1
Onchocerca volvulus Alhambra homolog 0.0029 0.015 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.0143 0.05
Echinococcus granulosus GPCR family 2 0.0082 0.0762 0.0772
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0653 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0653 0.0779

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 53.28 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
Potency (functional) 1.5101 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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