Detailed information for compound 1328495

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 520.961 | Formula: C23H22ClFN4O5S
  • H donors: 0 H acceptors: 5 LogP: 2.46 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(cc1C(=O)N(C1CC1)Cc1nnc(o1)c1ccccc1Cl)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C23H22ClFN4O5S/c24-19-4-2-1-3-17(19)22-27-26-21(34-22)14-29(15-5-6-15)23(30)18-13-16(7-8-20(18)25)35(31,32)28-9-11-33-12-10-28/h1-4,7-8,13,15H,5-6,9-12,14H2
  • InChiKey: ZAFXDSCWSIVVIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0141 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0097 0.0573 0.0622
Loa Loa (eye worm) hypothetical protein 0.0093 0.0538 0.0584
Echinococcus granulosus casein kinase ii subunit alpha 0.0092 0.0527 0.0527
Plasmodium falciparum calcium-dependent protein kinase 1 0.0044 0.0067 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.0464 0.181
Loa Loa (eye worm) TK/EGFR protein kinase 0.0646 0.5804 0.6297
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0155 0.1128 0.1256
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0123 0.0821 0.3636
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0123 0.0821 0.0821
Entamoeba histolytica casein kinase, putative 0.006 0.0224 0.0954
Entamoeba histolytica protein kinase, putative 0.0053 0.0157 0.0664
Echinococcus multilocularis Glutaredoxin protein 5 0.0134 0.0928 0.1033
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0077 0.0381 0.0424
Echinococcus multilocularis tyrosine protein kinase HCK 0.0097 0.0577 0.0642
Entamoeba histolytica protein kinase, putative 0.0116 0.0755 0.326
Toxoplasma gondii AGC kinase 0.0062 0.0247 0.1075
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0159 0.1167 0.5017
Schistosoma mansoni unc-13 (munc13) 0.0041 0.0039 0.0067
Brugia malayi RNA binding protein 0.0073 0.0343 0.0372
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0141 0.0995 0.4302
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0141 0.0995 0.4302
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0077 0.0381 0.0424
Schistosoma mansoni tyrosine kinase 0.042 0.3655 0.6298
Brugia malayi Protein kinase domain containing protein 0.0112 0.0719 0.0781
Brugia malayi SH2 domain containing protein 0.0066 0.0276 0.03
Loa Loa (eye worm) raf kinase 0.0037 0.0005 0.0006
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0066 0.0276 0.1181
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0026 0.0029
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.006 0.0224 0.025
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0043 0.0065 0.0065
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.0113 0.0126
Leishmania major casein kinase II, putative 0.0092 0.0527 0.2076
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0247 0.0274
Echinococcus granulosus GPCR family 2 0.0227 0.1815 0.1815
Onchocerca volvulus 0.0316 0.2668 0.7996
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0247 0.0274
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0074 0.0357 0.1405
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.041 0.3562 0.3865
Echinococcus granulosus rho-associated protein kinase 1 0.0336 0.2849 0.2849
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0888 0.3774
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0044 0.0067 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0343 0.0591
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0006
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0131 0.0898 0.8054
Brugia malayi protein kinase C3,putative 0.0146 0.1042 0.1131
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0112 0.0719 0.0781
Schistosoma mansoni nephrin 0.0087 0.0479 0.0824
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0129 0.0882 0.0882
Brugia malayi glutaminase DH11.1 0.0266 0.2187 0.2373
Trichomonas vaginalis STE family protein kinase 0.0077 0.0381 0.1439
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.2283 0.9895
Onchocerca volvulus 0.0066 0.0276 0.0828
Plasmodium vivax unspecified product 0.0092 0.0527 0.4631
Schistosoma mansoni unc-13 (munc13) 0.0038 0.0018 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0067 0.0043
Echinococcus multilocularis activin receptor type 0.0053 0.0153 0.017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0227 0.1815 0.2021
Echinococcus granulosus twitchin 0.0103 0.0635 0.0635
Trypanosoma cruzi casein kinase, putative 0.006 0.0224 0.081
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0038 0.0018 0.0018
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0092 0.0527 0.4631
Echinococcus granulosus activin receptor type 0.0053 0.0153 0.0153
Leishmania major protein kinase A catalytic subunit isoform 1 0.0062 0.0247 0.0813
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0331 0.2806 0.3044
Plasmodium falciparum calcium-dependent protein kinase 5 0.0044 0.0067 0.0005
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0141 0.0995 0.1107
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0888 0.7875
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0799 0.1376
Brugia malayi Variant SH3 domain containing protein 0.0069 0.031 0.0336
Schistosoma mansoni tyrosine kinase 0.0091 0.0523 0.09
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0112 0.0719 0.0719
Echinococcus multilocularis casein kinase I alpha 0.006 0.0224 0.0249
Schistosoma mansoni hypothetical protein 0.0037 0.0005 0.0009
Echinococcus granulosus unc 13 munc13 0.0038 0.0018 0.0018
Echinococcus granulosus protein kinase c iota type 0.0266 0.2183 0.2183
Echinococcus granulosus Immunoglobulin 0.0069 0.0312 0.0312
Entamoeba histolytica protein kinase, putative 0.0279 0.2307 1
Schistosoma mansoni tyrosine kinase 0.0646 0.5804 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0227 0.1815 0.197
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0155 0.1128 0.1256
Giardia lamblia Kinase, NEK 0.0131 0.0898 0.3754
Onchocerca volvulus 0.0088 0.0494 0.1482
Brugia malayi Protein kinase domain containing protein 0.0066 0.0276 0.03
Schistosoma mansoni protein kinase 0.0053 0.0157 0.0271
Entamoeba histolytica protein kinase, putative 0.006 0.0224 0.0956
Schistosoma mansoni ephrin receptor 0.0103 0.0632 0.1089
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0343 0.0382
Loa Loa (eye worm) AGC/NDR protein kinase 0.0139 0.0973 0.1056
Echinococcus granulosus cyclin dependent kinase 0.0112 0.0719 0.0719
Leishmania major protein kinase, putative 0.0053 0.0153 0.039
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0155 0.1128 0.1256
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Echinococcus multilocularis mitogen activated protein kinase 11 0.0156 0.1136 0.1264
Onchocerca volvulus 0.0066 0.0276 0.0828
Echinococcus multilocularis protein kinase shaggy 0.0123 0.0821 0.0914
Plasmodium falciparum casein kinase 2, alpha subunit 0.0092 0.0527 0.4409
Brugia malayi Calcitonin receptor-like protein seb-1 0.0718 0.649 0.7041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0067 0.0074
Echinococcus granulosus NDR protein kinase 0.0139 0.0973 0.0973
Echinococcus granulosus protein kinase C gamma type 0.0183 0.1396 0.1396
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0112 0.0719 0.2946
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0357 0.1405
Echinococcus granulosus tyrosine protein kinase Blk 0.0129 0.0882 0.0882
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0123 0.0821 0.1415
Echinococcus multilocularis nervana 2 0.0134 0.0928 0.1033
Schistosoma mansoni hypothetical protein 0.0058 0.0206 0.0356
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0063 0.0256 0.0277
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0224 0.0742
Echinococcus granulosus cyclin dependent kinase 5 0.0112 0.0719 0.0719
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0085 0.0464 0.0504
Schistosoma mansoni protein kinase 0.0077 0.0381 0.0656
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0192 0.1483 0.4444
Schistosoma mansoni nck2/grb4 0.0058 0.0203 0.035
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0043 0.0057 0.0065
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0248 0.2018 0.2018
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0224 0.0742
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.1371 0.4107
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0247 0.0268
Onchocerca volvulus 0.0131 0.0904 0.2711
Schistosoma mansoni tyrosine kinase 0.0091 0.0523 0.09
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0719 0.124
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0227 0.1815 0.2021
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0367 0.1448
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0472 0.4151 0.4151
Echinococcus granulosus neuroglian 0.0084 0.0454 0.0454
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0153 0.111 0.4764
Echinococcus granulosus casein kinase I delta 0.006 0.0224 0.0224
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0821 0.3406
Echinococcus granulosus Protein kinase C brain isozyme 0.022 0.1749 0.1749
Echinococcus granulosus tyrosine protein kinase shark 0.0066 0.0276 0.0276
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0067 0.0074
Echinococcus multilocularis unc 13 (munc13) 0.0038 0.0018 0.002
Echinococcus granulosus Diacylglycerol kinase theta 0.0037 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0799 0.1376
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0201 0.1565 0.1565
Echinococcus granulosus insulin receptor 0.0469 0.4126 0.4126
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0156 0.1136 0.4879
Schistosoma mansoni rac gtpase activating protein 0.0037 0.0005 0.0009
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0247 0.0268
Brugia malayi serine/threonine-protein kinase plk-2 0.0276 0.2283 0.2477
Toxoplasma gondii casein kinase I 0.006 0.0224 0.0975
Brugia malayi MH2 domain containing protein 0.0365 0.3126 0.3392
Echinococcus multilocularis protein kinase c iota type 0.0266 0.2183 0.2429
Schistosoma mansoni tyrosine kinase 0.042 0.3655 0.6298
Brugia malayi hypothetical protein 0.0084 0.045 0.0488
Loa Loa (eye worm) AUR protein kinase 0.0141 0.0995 0.1079
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0276 0.2283 0.2477
Loa Loa (eye worm) glutaminase 2 0.0266 0.2187 0.2373
Brugia malayi RhoGAP domain containing protein 0.0069 0.031 0.0336
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0248 0.2018 0.2246
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0044 0.0067 0.0067
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0155 0.1128 0.1256
Brugia malayi serine/threonine kinase 12 0.0141 0.0995 0.1079
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0527 0.2086
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0123 0.0821 0.3476
Loa Loa (eye worm) AGC/PKN protein kinase 0.0139 0.0973 0.1056
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0247 0.0804
Loa Loa (eye worm) hypothetical protein 0.013 0.0888 0.0964
Echinococcus granulosus dual specificity 0.0116 0.0755 0.0755
Echinococcus multilocularis serine:threonine protein kinase N2 0.0139 0.0973 0.1084
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0224 0.0387
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.2283 0.9895
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0973 0.4073
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0153 0.111 0.1235
Trypanosoma cruzi cdc2-related kinase 1 0.0112 0.0719 0.3021
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0074 0.0357 0.0388
Trichomonas vaginalis AGC family protein kinase 0.0279 0.2307 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0053 0.0153 0.0492
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0527 0.2086
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0148 0.1061 0.1152
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0247 0.0911
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0145 0.1029 0.1117
Brugia malayi serine/threonine-protein kinase 6 0.0141 0.0995 0.1079
Brugia malayi SRC-1 0.0155 0.1128 0.1224
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.023 0.1842 0.1998
Brugia malayi Protein kinase domain containing protein 0.0189 0.1453 0.1577
Loa Loa (eye worm) hypothetical protein 0.0062 0.0247 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0006
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0077 0.0381 0.0381
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0755 0.326
Plasmodium falciparum NIMA related kinase 1 0.0131 0.0898 0.7974
Entamoeba histolytica serine/threonine protein kinase, putative 0.0276 0.2283 0.9897
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0464 0.08
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0973 0.4073
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Echinococcus granulosus protein kinase c epsilon type 0.0177 0.134 0.134
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0116 0.0755 0.0819
Plasmodium falciparum calcium-dependent protein kinase 2 0.0044 0.0067 0.0005
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0139 0.0973 0.0973
Echinococcus multilocularis death associated protein kinase 1 0.0902 0.8251 0.9184
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0334 0.1231
Loa Loa (eye worm) TK/EPH protein kinase 0.0122 0.0813 0.0883
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0044 0.0067 0.0275
Brugia malayi Fibronectin type III domain containing protein 0.0072 0.0337 0.0365
Giardia lamblia Kinase, PLK 0.0276 0.2283 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.029 0.2417 0.2691
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0043 0.0061 0.0068
Trypanosoma cruzi p21-activated kinase 3, putative 0.0043 0.0057 0.0065
Plasmodium vivax calcium-dependent protein kinase, putative 0.0044 0.0067 0.0401
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.2283 0.3934
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0038 0.0018 0.002
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0247 0.0268
Trypanosoma cruzi polo-like protein kinase, putative 0.0276 0.2283 1
Loa Loa (eye worm) TK protein kinase 0.0263 0.216 0.2343
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0005 0.0004
Loa Loa (eye worm) TK protein kinase 0.0129 0.0882 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0044 0.0067 0.0275
Brugia malayi Protein kinase domain containing protein 0.0139 0.0973 0.1056
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1061 0.1829
Echinococcus granulosus tyrosine protein kinase Src42A 0.0155 0.1128 0.1128
Schistosoma mansoni hypothetical protein 0.0491 0.4326 0.7454
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0173 0.1302 0.1302
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0542 0.0933
Echinococcus granulosus Rac GTPase activating protein 1 0.0037 0.0005 0.0005
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0112 0.0719 0.0781
Loa Loa (eye worm) AUR protein kinase 0.0141 0.0995 0.1079
Trypanosoma cruzi casein kinase, putative 0.006 0.0224 0.081
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0053 0.0153 0.0658
Leishmania major protein kinase, putative 0.0044 0.0067 0.0002
Loa Loa (eye worm) hypothetical protein 0.0119 0.079 0.0857
Schistosoma mansoni tyrosine kinase 0.0387 0.3336 0.5747
Echinococcus granulosus c-Jun N-terminal kinases 0.027 0.2221 0.2221
Loa Loa (eye worm) hypothetical protein 0.0129 0.088 0.0955
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0798 0.3292
Brugia malayi Variant SH3 domain containing protein 0.0058 0.0203 0.022
Schistosoma mansoni hypothetical protein 0.0227 0.1815 0.3128
Trichomonas vaginalis STE family protein kinase 0.0077 0.0381 0.1439
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0074 0.0357 0.1299
Giardia lamblia Kinase, CMGC MAPK 0.0074 0.0357 0.1313
Schistosoma mansoni tyrosine kinase 0.0387 0.3336 0.5747
Entamoeba histolytica protein kinase 2, putative 0.0153 0.111 0.4802
Brugia malayi Tyrosine-protein kinase abl-1 0.0177 0.1341 0.1455
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0248 0.2018 0.2246
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0153 0.111 0.111
Echinococcus multilocularis tyrosine protein kinase Srms 0.0129 0.0882 0.0981
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0367 0.1448
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0343 0.0591
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0821 0.0891
Echinococcus granulosus casein kinase I alpha 0.006 0.0224 0.0224
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0153 0.111 1
Brugia malayi RhoGEF domain containing protein 0.0037 0.0005 0.0006
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0026 0.0029
Entamoeba histolytica protein kinase, putative 0.0123 0.0821 0.3549
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0005 0.0009
Brugia malayi Protein kinase domain containing protein 0.0066 0.0276 0.03
Trypanosoma cruzi Protein kinase B 0.0159 0.1167 0.5017
Echinococcus granulosus tyrosine protein kinase Src42A 0.0096 0.0562 0.0562
Brugia malayi protein kinase C II. 0.0177 0.134 0.1454
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0247 0.0911
Echinococcus multilocularis growth factor receptor bound protein 2 0.0058 0.0203 0.0226
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.027 0.2221 0.241
Onchocerca volvulus 0.0066 0.0276 0.0828
Entamoeba histolytica hypothetical protein 0.0116 0.0755 0.326
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0247 0.0425
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0044 0.0067 0.0401
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0821 0.3406
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Entamoeba histolytica protein kinase, putative 0.0116 0.0755 0.326
Echinococcus granulosus mitogen activated protein kinase 0.0074 0.0357 0.0357
Echinococcus granulosus protein kinase c eta type 0.0037 0.0005 0.0005
Echinococcus multilocularis mitogen activated protein kinase 14 0.0156 0.1136 0.1264
Loa Loa (eye worm) hypothetical protein 0.0097 0.0573 0.0622
Echinococcus granulosus serine:threonine kinase SAD 1 0.0043 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0088 0.0494 0.0536
Loa Loa (eye worm) hypothetical protein 0.008 0.0414 0.045
Echinococcus granulosus tyrosine kinase 0.0129 0.0882 0.0882
Echinococcus multilocularis rac serine:threonine kinase 0.0159 0.1167 0.1299
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0075 0.0367 0.1575
Brugia malayi Tyrosine-protein kinase abl-1 0.0139 0.0974 0.1057
Loa Loa (eye worm) hypothetical protein 0.0088 0.0494 0.0536
Echinococcus multilocularis mitogen activated protein kinase 0.0074 0.0357 0.0398
Brugia malayi Protein kinase domain 0.0077 0.0381 0.0413
Echinococcus multilocularis epidermal growth factor receptor 0.042 0.3655 0.4069
Trichomonas vaginalis STE family protein kinase 0.0053 0.0157 0.0444
Plasmodium falciparum casein kinase 1 0.006 0.0224 0.1511
Echinococcus granulosus epidermal growth factor receptor 0.0646 0.5804 0.5804
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0062 0.0247 0.0804
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0821 0.3549
Echinococcus multilocularis protein kinase c eta type 0.0037 0.0005 0.0006
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0262 0.2144 0.2327
Echinococcus multilocularis ephrin type A receptor 4 A 0.0103 0.0632 0.0704
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Echinococcus multilocularis casein kinase i 0.006 0.0224 0.0249
Schistosoma mansoni tyrosine kinase 0.0258 0.2113 0.364
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0044 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.015 0.1084 0.1177
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0224 0.0386
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0192 0.1483 0.1609
Echinococcus multilocularis Immunoglobulin 0.0069 0.0312 0.0347
Entamoeba histolytica protein kinase, putative 0.0044 0.0067 0.0272
Trypanosoma cruzi casein kinase II, putative 0.0092 0.0527 0.216
Trypanosoma brucei protein kinase, putative 0.0053 0.0153 0.0386
Echinococcus granulosus casein kinase I delta 0.006 0.0224 0.0224
Echinococcus granulosus tar DNA binding protein 0.0073 0.0343 0.0343
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0821 0.3549
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0005 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Echinococcus granulosus serine threonine protein kinase nrc 0.0153 0.111 0.111
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0057 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.2283 0.9895
Echinococcus multilocularis hypothetical protein 0.0066 0.0283 0.0315
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0044 0.0067 0.0073
Brugia malayi cell division control protein 2 homolog 0.0112 0.0719 0.0781
Brugia malayi ephrin receptor 1 precursor 0.0066 0.0283 0.0307
Schistosoma mansoni protein kinase 0.0092 0.0527 0.0907
Loa Loa (eye worm) AUR protein kinase 0.0141 0.0995 0.1079
Brugia malayi Protein kinase domain containing protein 0.0139 0.0973 0.1056
Giardia lamblia Kinase, AGC PKA 0.0153 0.111 0.4708
Loa Loa (eye worm) hypothetical protein 0.0069 0.0312 0.0338
Trypanosoma brucei PAB1-binding protein , putative 0.013 0.0888 0.3668
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0066 0.0114
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0096 0.0562 0.0626
Onchocerca volvulus 0.0066 0.0276 0.0828
Loa Loa (eye worm) hypothetical protein 0.0069 0.0314 0.0341
Trichomonas vaginalis AGC family protein kinase 0.0145 0.103 0.4325
Echinococcus granulosus NCK adaptor protein 0.0058 0.0203 0.0203
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0206 0.023
Echinococcus granulosus epidermal growth factor receptor 0.042 0.3655 0.3655
Trichomonas vaginalis glutaminase, putative 0.0266 0.2187 0.9469
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0325 0.0559
Trypanosoma cruzi cdc2-related kinase 3 0.0112 0.0719 0.3021
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Loa Loa (eye worm) hypothetical protein 0.01 0.0603 0.0654
Brugia malayi Protein kinase domain containing protein 0.0116 0.0755 0.0819
Onchocerca volvulus 0.0336 0.2849 0.854
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.0113 0.0113
Echinococcus granulosus casein kinase I alpha 0.006 0.0224 0.0224
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0155 0.1128 0.1256
Schistosoma mansoni serine/threonine kinase 0.0139 0.0973 0.1677
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.1167 0.5049
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.3126 0.3392
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0072 0.0334 0.0363
Loa Loa (eye worm) hypothetical protein 0.0131 0.0904 0.0981
Trypanosoma brucei polo-like protein kinase 0.0276 0.2283 0.9894
Brugia malayi Protein kinase domain containing protein 0.0279 0.2307 0.2503
Schistosoma mansoni protein kinase 0.0221 0.1758 0.3029
Schistosoma mansoni tyrosine kinase 0.0469 0.4126 0.7109
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0112 0.0719 0.2946
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0077 0.0381 0.0381
Echinococcus granulosus aurora kinase A 0.0141 0.0995 0.0995
Schistosoma mansoni protein kinase 0.0044 0.0067 0.0115
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0236 0.19 0.2114
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Echinococcus granulosus c src tyrosine kinase 0.0091 0.0523 0.0523
Brugia malayi Casein kinase II, alpha chain 0.0092 0.0527 0.0571
Echinococcus multilocularis PAK box P21 Rho binding 0.0053 0.0157 0.0175
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0821 0.0891
Onchocerca volvulus 0.0066 0.0276 0.0828
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0006
Leishmania major protein kinase A catalytic subunit isoform 2 0.0062 0.0247 0.0813
Toxoplasma gondii histone kinase SNF1, putative 0.0043 0.0066 0.0273
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0075 0.0367 0.1342
Trichomonas vaginalis AGC family protein kinase 0.0279 0.2307 1
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0973 0.1677
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0044 0.0067 0.0073
Schistosoma mansoni hypothetical protein 0.0227 0.1815 0.3128
Brugia malayi MAP kinase sur-1 0.0074 0.0357 0.0388
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0177 0.134 0.1454
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0671 0.2729
Brugia malayi diacylglycerol kinase 0.0037 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0718 0.649 0.7041
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0148 0.1061 0.1061
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.1566 0.2697
Echinococcus granulosus mitogen activated protein kinase 3 0.0074 0.0357 0.0357
Schistosoma mansoni tyrosine kinase 0.0155 0.1128 0.1943
Brugia malayi Hr1 repeat family protein 0.0139 0.0973 0.1056
Echinococcus multilocularis N chimaerin 0.0069 0.031 0.0345
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0069 0.031 0.0345
Loa Loa (eye worm) TK protein kinase 0.0097 0.0577 0.0626
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0092 0.0527 0.0571
Echinococcus multilocularis NCK adaptor protein 0.0058 0.0203 0.0226
Brugia malayi hypothetical protein 0.013 0.0888 0.0964
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0116 0.0758 0.3122
Schistosoma mansoni ste20-related kinase 0.0206 0.1611 0.2775
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Loa Loa (eye worm) hypothetical protein 0.0156 0.1134 0.123
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0069 0.0312 0.0537
Echinococcus multilocularis cyclin dependent kinase 1 0.0112 0.0719 0.0801
Echinococcus multilocularis aurora kinase A 0.0141 0.0995 0.1107
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0112 0.0719 0.3182
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0091 0.0523 0.09
Brugia malayi Pleckstrin Homology Domain 0.0043 0.0062 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0227 0.1815 0.197
Loa Loa (eye worm) hypothetical protein 0.01 0.0603 0.0654
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0718 0.649 0.7041
Echinococcus multilocularis casein kinase I alpha 0.006 0.0224 0.0249
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0006
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0247 0.2054
Onchocerca volvulus Tyrosine kinase homolog 0.0387 0.3337 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0247 0.0911
Loa Loa (eye worm) hypothetical protein 0.0069 0.0312 0.0338
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0043 0.0057 0.0062
Schistosoma mansoni serine/threonine kinase 0.0085 0.0464 0.08
Echinococcus multilocularis cyclin dependent kinase 0.0112 0.0719 0.0801
Brugia malayi intracellular kinase 0.0123 0.0821 0.0891
Brugia malayi latrophilin 2 splice variant baaae 0.0491 0.4326 0.4694
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0357 0.0616
Echinococcus multilocularis tyrosine kinase 0.0066 0.0276 0.0307
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0236 0.19 0.19
Loa Loa (eye worm) hypothetical protein 0.0058 0.0203 0.022
Echinococcus multilocularis serine:threonine protein kinase 38 0.0139 0.0973 0.1084
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0062 0.0247 0.1075
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0798 0.3292
Echinococcus granulosus serine:threonine protein kinase 0.0107 0.0671 0.0671
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0075 0.0367 0.1575
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0148 0.1061 0.1152
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0247 0.0274
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0139 0.0973 0.0973
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1004 0.9217 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0155 0.1128 0.1128
Onchocerca volvulus 0.0069 0.0313 0.0937
Entamoeba histolytica protein kinase , putative 0.0141 0.0995 0.4302
Loa Loa (eye worm) hypothetical protein 0.015 0.1084 0.1177
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0043 0.0066 0.0106
Trypanosoma cruzi cdc2-related kinase 3 0.0112 0.0719 0.3021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0357 0.1335
Toxoplasma gondii aurora kinase 0.0141 0.0995 0.4409
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0192 0.1483 0.1609
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0053 0.0153 0.0492
Echinococcus granulosus tyrosine protein kinase Srms 0.0066 0.0276 0.0276
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0053 0.0153 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0343 0.0591
Loa Loa (eye worm) hypothetical protein 0.0072 0.0337 0.0365
Schistosoma mansoni tyrosine kinase 0.0248 0.2018 0.3477
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0357 0.1335
Loa Loa (eye worm) hypothetical protein 0.0043 0.0066 0.0072
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0173 0.1302 0.1449
Loa Loa (eye worm) TK/INSR protein kinase 0.0469 0.4126 0.4477
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.1302 0.2243
Loa Loa (eye worm) hypothetical protein 0.0038 0.0018 0.002
Entamoeba histolytica protein kinase, putative 0.0141 0.0995 0.4302
Toxoplasma gondii LsmAD domain-containing protein 0.013 0.0888 0.3934
Loa Loa (eye worm) hypothetical protein 0.0043 0.0062 0.0067
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0043 0.0066 0.0072
Echinococcus granulosus tyrosine protein kinase Fyn 0.0155 0.1128 0.1128
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0077 0.0381 0.0424
Echinococcus multilocularis serine:threonine protein kinase 0.0107 0.0671 0.0747
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Echinococcus granulosus serine:threonine protein kinase N2 0.0139 0.0973 0.0973
Onchocerca volvulus 0.0041 0.0043 0.0128
Echinococcus multilocularis protein kinase c epsilon type 0.0177 0.134 0.1491
Brugia malayi Protein kinase domain containing protein 0.0192 0.1483 0.1609
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.023 0.1842 0.205
Echinococcus granulosus serine:threonine protein kinase Chk2 0.006 0.0224 0.0224
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0235 0.1889 0.2049
Loa Loa (eye worm) hypothetical protein 0.0125 0.0848 0.092
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0005 0.0009
Echinococcus multilocularis serine:threonine protein kinase N2 0.0139 0.0973 0.1084
Schistosoma mansoni tyrosine kinase 0.0068 0.0295 0.0509
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0066 0.0114
Brugia malayi Furin-like cysteine rich region family protein 0.0646 0.5804 0.6297
Giardia lamblia Kinase, NEK 0.0131 0.0898 0.3754
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0343 0.0372
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0085 0.0461 0.0461
Plasmodium falciparum calcium-dependent protein kinase 4 0.0044 0.0067 0.0005
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0224 0.0243
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0155 0.1128 0.1256
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0472 0.4151 0.462
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0066 0.0276 0.0307
Brugia malayi phosphoinositide-dependent protein kinase I 0.0072 0.0334 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0066 0.0114
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0882 0.0981
Trypanosoma cruzi cdc2-related kinase 1 0.0112 0.0719 0.3021
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0276 0.2283 1
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0107 0.0671 0.0728
Giardia lamblia Kinase, CMGC CDK 0.0112 0.0719 0.2946
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0037 0.0005 0.0006
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0156 0.1136 0.4824
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0123 0.0821 0.3406
Echinococcus multilocularis Rac GTPase activating protein 1 0.0037 0.0005 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.02 0.0633
Schistosoma mansoni protein kinase 0.006 0.0224 0.0386
Echinococcus granulosus nervana 2 0.0134 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0491 0.4326 0.4694
Loa Loa (eye worm) hypothetical protein 0.018 0.1371 0.1487
Echinococcus multilocularis GPCR, family 2 0.0227 0.1815 0.2021
Schistosoma mansoni protein kinase 0.0077 0.0381 0.0656
Echinococcus granulosus Glutaredoxin protein 5 0.0134 0.0928 0.0928
Brugia malayi p70 ribosomal S6 kinase beta 0.0273 0.225 0.2441
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0343 0.0372
Brugia malayi Protein kinase domain containing protein 0.0085 0.0464 0.0504
Echinococcus multilocularis 0.0188 0.1445 0.1608
Schistosoma mansoni growth factor receptor-bound protein 0.0058 0.0203 0.035
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.012 0.0799 0.0889
Loa Loa (eye worm) RNA binding protein 0.0073 0.0343 0.0372
Loa Loa (eye worm) hypothetical protein 0.0069 0.0313 0.0339
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Loa Loa (eye worm) SRC-1 0.0155 0.1128 0.1224
Schistosoma mansoni tyrosine kinase 0.0469 0.4126 0.7109
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.134 0.2308
Giardia lamblia Kinase, CMGC CK2 0.0092 0.0527 0.2076
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0123 0.0821 0.0914
Giardia lamblia Kinase, AGC AKT 0.011 0.0702 0.2866
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0247 0.0804
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0116 0.0755 0.3073
Entamoeba histolytica protein kinase, putative 0.0072 0.0334 0.1433
Brugia malayi Protein kinase domain containing protein 0.1004 0.9217 1
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.014 0.0988 0.0988
Brugia malayi Protein kinase domain containing protein 0.0201 0.1566 0.1699
Trichomonas vaginalis AGC family protein kinase 0.0141 0.0995 0.4168
Loa Loa (eye worm) hypothetical protein 0.0066 0.0276 0.03
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.0303 0.1299
Echinococcus multilocularis tyrosine protein kinase Abl 0.0177 0.1341 0.1493
Trichomonas vaginalis AGC family protein kinase 0.0279 0.2307 1
Echinococcus multilocularis neuroglian 0.0084 0.0454 0.0505
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0067 0.0115
Schistosoma mansoni tyrosine kinase 0.021 0.1653 0.2848
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0139 0.0973 0.1056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0044 0.0067 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0973 0.1677
Entamoeba histolytica casein kinase, putative 0.0092 0.0527 0.2268
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0153 0.1105 0.1199
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0131 0.0898 0.3979
Brugia malayi N-terminal motif family protein 0.018 0.1371 0.1487
Brugia malayi ribosomal protein S6 kinase alpha 3 0.011 0.0702 0.0761
Plasmodium vivax ataxin-2 like protein, putative 0.013 0.0888 0.796
Echinococcus multilocularis cyclin dependent kinase 1 0.0112 0.0719 0.0801
Brugia malayi casein kinase I 0.006 0.0224 0.0243
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0148 0.1061 0.1181
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0973 0.4073
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0201 0.1565 0.1742
Brugia malayi Temporarily assigned gene name protein 59 0.014 0.0984 0.1067
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0527 0.2268
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0888 0.3774
Schistosoma mansoni vesicular amine transporter 0.0069 0.0312 0.0537
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0074 0.0357 0.1313
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Echinococcus granulosus growth factor receptor bound protein 2 0.0058 0.0203 0.0203
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0116 0.0755 0.3106
Loa Loa (eye worm) hypothetical protein 0.0044 0.0067 0.0073
Plasmodium falciparum calcium-dependent protein kinase 3 0.0044 0.0067 0.0005
Leishmania major casein kinase, putative 0.006 0.0224 0.0711
Echinococcus multilocularis cyclin dependent kinase 5 0.0112 0.0719 0.0801
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0155 0.1128 0.1128
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0527 0.2086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0263 0.216 0.2343
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Loa Loa (eye worm) hypothetical protein 0.0072 0.0337 0.0365
Loa Loa (eye worm) glutaminase 0.0266 0.2187 0.2373
Trichomonas vaginalis AGC family protein kinase 0.0141 0.0995 0.4168
Schistosoma mansoni growth factor receptor-bound protein 0.0058 0.0203 0.035
Onchocerca volvulus 0.0038 0.0018 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.1302 0.2243
Trichomonas vaginalis AGC family protein kinase 0.0279 0.2307 1
Echinococcus multilocularis roundabout 2 0.0102 0.0628 0.0699
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0276 0.2283 0.2283
Trypanosoma cruzi casein kinase, putative 0.006 0.0224 0.081
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0156 0.1136 0.4879
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.1167 0.201
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0337 0.0365
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0206 0.0206
Giardia lamblia Kinase, CMGC CDK 0.0112 0.0719 0.2946
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.006 0.0224 0.025
Trypanosoma brucei protein kinase, putative 0.0074 0.0357 0.1299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0718 0.649 0.7041
Echinococcus granulosus tyrosine kinase 0.0066 0.0276 0.0276
Trypanosoma brucei rac serine-threonine kinase, putative 0.0279 0.2307 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0227 0.1815 0.197
Echinococcus granulosus cyclin dependent kinase 1 0.0112 0.0719 0.0719
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Brugia malayi Protein kinase domain containing protein 0.0066 0.0276 0.03
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.006 0.0224 0.0243
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.1167 0.5049
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0192 0.1483 0.1483
Brugia malayi Protein kinase domain containing protein 0.0066 0.0276 0.03
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0074 0.0357 0.1569
Brugia malayi protein-tyrosine kinase 0.0129 0.0882 0.0956
Trypanosoma brucei casein kinase I, isoform 2 0.006 0.0224 0.0704
Plasmodium falciparum glycogen synthase kinase 3 0.0123 0.0821 0.7235
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0273 0.225 0.2441
Echinococcus granulosus RNA directed DNA polymerase 0.0043 0.0061 0.0061
Schistosoma mansoni adapter molecule crk 0.0058 0.0203 0.035
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.0303 0.1299
Entamoeba histolytica cell division protein kinase 2, putative 0.0112 0.0719 0.3106
Loa Loa (eye worm) RasGEF domain-containing protein 0.0039 0.0025 0.0028
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0134 0.0928 0.1033
Echinococcus multilocularis RNA directed DNA polymerase 0.0043 0.0061 0.0068
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0069 0.0312 0.0347
Brugia malayi Protein kinase domain containing protein 0.0107 0.0671 0.0728
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0247 0.0247
Brugia malayi hypothetical protein 0.0066 0.0276 0.03
Mycobacterium ulcerans glutaminase 0.0266 0.2187 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0155 0.1128 0.1128
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0973 0.1677
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.012 0.0799 0.0799
Trichomonas vaginalis AGC family protein kinase 0.0279 0.2307 1
Entamoeba histolytica protein kinase, putative 0.0139 0.0973 0.4209
Trichomonas vaginalis STE family protein kinase 0.0075 0.0367 0.1377
Schistosoma mansoni tyrosine kinase 0.0387 0.3336 0.5747
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0334 0.1231
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0247 0.0247
Plasmodium falciparum protein kinase 5 0.0112 0.0719 0.6259
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Leishmania major hypothetical protein, conserved 0.013 0.0888 0.3707
Schistosoma mansoni protein kinase 0.0044 0.0067 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Entamoeba histolytica protein kinase, putative 0.0059 0.0214 0.091
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0067 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0821 0.3397
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0112 0.0719 0.0781
Loa Loa (eye worm) latrophilin receptor protein 2 0.0227 0.1815 0.197
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0066 0.0114
Entamoeba histolytica cell division protein kinase 2, putative 0.0112 0.0719 0.3106
Loa Loa (eye worm) hypothetical protein 0.0066 0.0283 0.0307
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0719 0.2944
Echinococcus granulosus tyrosine protein kinase HCK 0.0097 0.0577 0.0577
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0043 0.0066 0.0396
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0464 0.08
Trypanosoma cruzi casein kinase, putative 0.006 0.0224 0.081
Schistosoma mansoni kinase 0.0296 0.2474 0.4262
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0343 0.0591
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0058 0.0203 0.022
Entamoeba histolytica protein kinase domain containing protein 0.0141 0.0995 0.4302
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.2283 0.9895
Schistosoma mansoni protein kinase C 0.0038 0.0018 0.0031
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0072 0.0334 0.0363
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0821 0.3397
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0995 0.1714
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0069 0.0312 0.0537
Brugia malayi RhoGAP domain containing protein 0.0037 0.0005 0.0006
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0052 0.015 0.0162
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0113 0.0123
Leishmania major protein kinase, putative 0.0075 0.0367 0.1356
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0247 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Brugia malayi Cam kinase protein 1 0.0044 0.0067 0.0073
Echinococcus multilocularis c Jun NH2 terminal kinase 0.027 0.2221 0.2472
Schistosoma mansoni hypothetical protein 0.0066 0.0283 0.0487
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0116 0.0755 0.3179
Echinococcus multilocularis casein kinase ii subunit alpha 0.0092 0.0527 0.0586
Onchocerca volvulus 0.015 0.1084 0.325
Entamoeba histolytica protein kinase, putative 0.0045 0.008 0.0329
Schistosoma mansoni hypothetical protein 0.0066 0.0283 0.0487
Echinococcus multilocularis calcium activated potassium channel 0.0085 0.0464 0.0517
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0247 0.0425
Echinococcus granulosus serine/threonine protein kinase 0.0159 0.1167 0.1167
Trichomonas vaginalis STE family protein kinase 0.0131 0.0898 0.374
Echinococcus multilocularis casein kinase I delta 0.006 0.0224 0.0249
Brugia malayi hypothetical protein 0.0072 0.0337 0.0365
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0044 0.0067 0.0074
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.3126 0.3392
Onchocerca volvulus 0.006 0.0224 0.0671
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.042 0.3655 0.3655
Schistosoma mansoni cell adhesion molecule 0.0088 0.0486 0.0838
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0247 0.0911
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0227 0.1815 0.1815
Echinococcus granulosus serine:threonine protein kinase 3 0.0262 0.2144 0.2144
Echinococcus multilocularis serine:threonine protein kinase 0.0107 0.0671 0.0747
Entamoeba histolytica protein kinase, putative 0.0141 0.0995 0.4302
Echinococcus multilocularis mitogen activated protein kinase 11 0.0156 0.1136 0.1264
Loa Loa (eye worm) hypothetical protein 0.015 0.1084 0.1177
Brugia malayi Stress-activated protein kinase jnk-1 0.027 0.2221 0.241
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0192 0.1483 0.1651
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0043 0.0066 0.0106
Plasmodium vivax casein kinase 1, putative 0.006 0.0224 0.1847
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0116 0.0755 0.3179
Brugia malayi Ras association domain family 1 isoform A 0.0037 0.0005 0.0006
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0139 0.0973 0.1084
Schistosoma mansoni tyrosine kinase 0.0064 0.0263 0.0453
Brugia malayi STE20-like kinase MST 0.0262 0.2144 0.2327
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0058 0.0203 0.022
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0077 0.0381 0.0381
Schistosoma mansoni serine/threonine protein kinase 0.0336 0.2849 0.4909
Schistosoma mansoni tyrosine kinase 0.0155 0.1128 0.1943
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0043 0.0065 0.0072
Schistosoma mansoni glutaminase 0.0266 0.2187 0.3768
Brugia malayi Protein kinase domain containing protein 0.0072 0.0334 0.0363
Brugia malayi Protein kinase c protein 2 0.01 0.0609 0.0661
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0276 0.03
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0224 0.0742
Echinococcus multilocularis epidermal growth factor receptor 0.0646 0.5804 0.6461
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.014 0.0988 0.11
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0134 0.0928 0.0928
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.2283 0.9895
Entamoeba histolytica protein kinase, putative 0.0051 0.0138 0.0581
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0074 0.0357 0.1313
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0044 0.0067 0.0067
Schistosoma mansoni vav2 0.0075 0.0367 0.0632
Schistosoma mansoni atypical protein kinase C 0.0272 0.2245 0.3869
Echinococcus multilocularis serine:threonine protein kinase 3 0.0262 0.2144 0.2387
Trypanosoma cruzi casein kinase, delta isoform, putative 0.006 0.0224 0.081
Trichomonas vaginalis STE family protein kinase 0.0077 0.0381 0.1439
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0173 0.1302 0.1449
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.2283 0.9895
Entamoeba histolytica serine/threonine protein kinase, putative 0.0043 0.0066 0.027
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0156 0.1136 0.4773
Brugia malayi map kinase activated protein kinase protein 2 0.041 0.3562 0.3865
Echinococcus granulosus MAP kinase activated protein kinase 2 0.041 0.3562 0.3562
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0155 0.1128 0.1256
Echinococcus granulosus ephrin type A receptor 4 A 0.0103 0.0632 0.0632
Brugia malayi putative serine/threonine kinase SADA gamma 0.0043 0.0066 0.0072
Echinococcus multilocularis Protein kinase C, brain isozyme 0.022 0.1749 0.1947
Echinococcus granulosus calcium activated potassium channel 0.0085 0.0464 0.0464
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0201 0.1566 0.1699
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0527 0.2086
Echinococcus multilocularis dual specificity 0.0116 0.0755 0.084
Echinococcus granulosus defective proboscis extension response 0.0069 0.0312 0.0312
Toxoplasma gondii CMGC kinase, CK2 family 0.0092 0.0527 0.2322
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0192 0.1483 0.1609
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0457 0.4004 0.4345
Brugia malayi Variant SH3 domain containing protein 0.0058 0.0203 0.022
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.041 0.3562 0.3965
Echinococcus granulosus mitogen activated protein kinase 11 0.0156 0.1136 0.1136
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0141 0.0995 0.4302
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0224 0.0243
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0173 0.1302 0.1302
Entamoeba histolytica hypothetical protein 0.0037 0.0005 0.0004
Echinococcus multilocularis mitogen activated protein kinase 3 0.0074 0.0357 0.0398
Echinococcus multilocularis casein kinase I alpha 0.006 0.0224 0.0249
Brugia malayi Sex muscle abnormal protein 5 0.0058 0.0203 0.022
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0247 0.0274
Trypanosoma brucei cdc2-related kinase 1 0.0112 0.0719 0.2915
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0719 0.2944
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0044 0.0067 0.0401
Brugia malayi casein kinase 1, delta 0.006 0.0224 0.0243
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0153 0.111 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0071 0.0325 0.0325
Giardia lamblia Kinase, STE STE20 0.0077 0.0381 0.1419
Loa Loa (eye worm) AGC/AKT protein kinase 0.0279 0.2307 0.2503
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0051 0.0138 0.0581
Giardia lamblia Kinase, NEK 0.0131 0.0898 0.3754
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0057 0.0099
Brugia malayi P38 map kinase family protein 2 0.0156 0.1136 0.1232
Trypanosoma cruzi aurora B kinase, putative 0.0141 0.0995 0.4251
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0527 0.2086
Brugia malayi serine/threonine protein kinase 6 0.0141 0.0995 0.1079
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0155 0.1128 0.1128
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0072 0.0334 0.0334
Brugia malayi Kinase associated domain 1 family protein 0.0066 0.0283 0.0307
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0139 0.0973 0.1084
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0357 0.1335
Giardia lamblia Aurora kinase 0.0141 0.0995 0.4189
Onchocerca volvulus 0.0066 0.0276 0.0828
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0755 0.1301
Echinococcus granulosus fibroblast growth factor receptor 4 0.0248 0.2018 0.2018
Trypanosoma cruzi casein kinase, putative 0.006 0.0224 0.081
Echinococcus granulosus roundabout 2 0.0102 0.0628 0.0628
Echinococcus multilocularis Diacylglycerol kinase theta 0.0037 0.0005 0.0006
Echinococcus granulosus myotubularin protein 13 0.0043 0.0062 0.0062
Echinococcus multilocularis myotubularin protein 13 0.0043 0.0062 0.0069
Plasmodium vivax protein kinase Crk2 0.0112 0.0719 0.6407
Plasmodium vivax glycogen synthase kinase 3, putative 0.0123 0.0821 0.7344
Schistosoma mansoni serine/threonine protein kinase 0.027 0.2221 0.3827
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0069 0.031 0.0534
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0888 0.7875
Echinococcus multilocularis raf serine:threonine protein kinase 0.0071 0.0325 0.0361
Toxoplasma gondii AGC kinase 0.0062 0.0247 0.1075
Brugia malayi TAR-binding protein 0.0073 0.0343 0.0372
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0357 0.1335
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0107 0.0676 0.0733
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0527 0.2086
Echinococcus granulosus casein kinase I alpha 0.006 0.0224 0.0224
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0357 0.1405
Brugia malayi Protein kinase domain containing protein 0.0185 0.1415 0.1535
Giardia lamblia Kinase, CK1 Casein kinase 0.006 0.0224 0.0711
Toxoplasma gondii AGC kinase 0.0273 0.225 1
Brugia malayi Protein kinase domain containing protein 0.0066 0.0276 0.03
Trichomonas vaginalis AGC family protein kinase 0.0131 0.0898 0.374
Echinococcus multilocularis tyrosine protein kinase Blk 0.0129 0.0882 0.0981
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0221 0.1758 0.1758
Echinococcus granulosus casein kinase i 0.006 0.0224 0.0224
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0276 0.2283 0.2541
Brugia malayi serine/threonine-protein kinase PAK 7 0.0235 0.1889 0.2049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0155 0.1128 0.1256
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.023 0.1842 0.1842
Schistosoma mansoni protein kinase C mu 0.0145 0.1029 0.1773
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0334 0.1231
Entamoeba histolytica protein kinase, putative 0.006 0.0224 0.0956
Echinococcus granulosus serine:threonine protein kinase 0.0107 0.0671 0.0671
Echinococcus granulosus nervana 2 0.0134 0.0928 0.0928
Echinococcus granulosus tyrosine protein kinase Lyn 0.0174 0.1309 0.1309
Echinococcus multilocularis c src tyrosine kinase 0.0091 0.0523 0.0582
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0062 0.0247 0.1727
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0069 0.031 0.031
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.1167 0.201
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0044 0.0067 0.0002
Brugia malayi Protein kinase domain containing protein 0.0469 0.4126 0.4477
Onchocerca volvulus 0.0047 0.0101 0.0302
Echinococcus multilocularis nervana 2 0.0134 0.0928 0.1033
Schistosoma mansoni protein kinase 0.0044 0.0067 0.0115
Echinococcus multilocularis rho associated protein kinase 0.0336 0.2849 0.3172
Giardia lamblia Kinase, AGC PKA 0.0062 0.0247 0.0813
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0145 0.1029 0.1117
Brugia malayi diacylglycerol kinase 0.0037 0.0005 0.0006
Schistosoma mansoni protein kinase 0.0141 0.0995 0.1714
Loa Loa (eye worm) hypothetical protein 0.0107 0.0671 0.0728
Echinococcus granulosus N chimaerin 0.0069 0.031 0.031
Trypanosoma brucei aurora B kinase 0.0141 0.0995 0.4144
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0153 0.0646
Trypanosoma cruzi polo-like protein kinase, putative 0.0276 0.2283 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0156 0.1136 0.1264
Onchocerca volvulus 0.0338 0.2875 0.8617
Plasmodium falciparum protein kinase, putative 0.0053 0.0153 0.0829
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1483 0.2555
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0343 0.0372
Schistosoma mansoni protein kinase C mu 0.0037 0.0005 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.2283 0.9895
Onchocerca volvulus 0.0125 0.0848 0.2541
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0221 0.1758 0.1957
Schistosoma mansoni hypothetical protein 0.0227 0.1815 0.3128
Loa Loa (eye worm) hypothetical protein 0.0187 0.1438 0.156
Echinococcus multilocularis serine threonine protein kinase 0.0183 0.1396 0.1554
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.041 0.3562 0.6138
Trichomonas vaginalis AGC family protein kinase 0.0279 0.2307 1
Entamoeba histolytica p21-activated kinase 0.0082 0.0438 0.1883
Trichomonas vaginalis AGC family protein kinase 0.0141 0.0995 0.4168
Schistosoma mansoni protein kinase 0.0053 0.0153 0.0263
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0044 0.0067 0.0401
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0527 0.2086
Entamoeba histolytica protein kinase, putative 0.0077 0.0381 0.1636
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.8984 1
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0066 0.0041
Entamoeba histolytica protein kinase, putative 0.0059 0.0214 0.091
Echinococcus granulosus protein kinase shaggy 0.0123 0.0821 0.0821
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0069 0.031 0.0336
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0058 0.0203 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0719 0.2944
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0037 0.0005 0.0006
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.012 0.0792 0.3266
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0044 0.0067 0.0073
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0216
Trypanosoma brucei Casein kinase II 0.0092 0.0527 0.2054
Entamoeba histolytica protein kinase, putative 0.0279 0.2307 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0066 0.0276 0.0276
Brugia malayi C1-like domain containing protein 0.0145 0.1029 0.1117
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0141 0.0995 0.8942
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0043 0.0057 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0334 0.0576
Echinococcus granulosus tyrosine protein kinase Fyn 0.0155 0.1128 0.1128
Giardia lamblia Kinase, STE STE20 0.0075 0.0367 0.1356
Trypanosoma brucei protein kinase, putative 0.0123 0.0821 0.337
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0069 0.031 0.0534
Loa Loa (eye worm) hypothetical protein 0.0289 0.2406 0.2611
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0043 0.0057 0.0062
Schistosoma mansoni hypothetical protein 0.0227 0.1815 0.3128
Trichomonas vaginalis AGC family protein kinase 0.0062 0.0247 0.0842
Echinococcus multilocularis tyrosine protein kinase shark 0.0066 0.0276 0.0307
Entamoeba histolytica protein kinase, putative 0.0097 0.0577 0.2486
Trypanosoma brucei cdc2-related kinase 3 0.0112 0.0719 0.2915
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0227 0.1815 0.1815
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.006 0.0224 0.0224
Echinococcus multilocularis casein kinase I delta 0.006 0.0224 0.0249
Plasmodium falciparum serine/threonine protein kinase, putative 0.0141 0.0995 0.8898
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0719 0.124
Echinococcus multilocularis myosin iiia 0.0075 0.0367 0.0408
Schistosoma mansoni serine/threonine protein kinase 0.022 0.1749 0.3013
Echinococcus granulosus tyrosine protein kinase ABL1 0.029 0.2417 0.2417
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1842 0.3173
Echinococcus multilocularis Immunoglobulin 0.0069 0.0312 0.0347
Loa Loa (eye worm) TK/ABL protein kinase 0.029 0.2417 0.2623
Entamoeba histolytica casein kinase 1, putative 0.006 0.0224 0.0954
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0464 0.08
Trichomonas vaginalis AGC family protein kinase 0.0279 0.2307 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0337 0.0365
Loa Loa (eye worm) hypothetical protein 0.0085 0.0461 0.0501
Brugia malayi SH2 domain containing protein 0.0066 0.0276 0.03
Brugia malayi Immunoglobulin I-set domain containing protein 0.0457 0.4004 0.4345
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0072 0.0334 0.0372
Leishmania major protein kinase, putative 0.0141 0.0995 0.4189
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0074 0.0357 0.1405
Echinococcus granulosus mitogen activated protein kinase 14 0.0156 0.1136 0.1136
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0247 0.0425
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0043 0.0066 0.0074
Schistosoma mansoni protein kinase 0.0221 0.1758 0.3029
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0155 0.1128 0.1256
Leishmania major protein kinase A catalytic subunit 0.0062 0.0247 0.0813
Onchocerca volvulus Serine\/threonine kinase homolog 0.0276 0.2283 0.6842
Entamoeba histolytica protein kinase, putative 0.0273 0.225 0.9753
Schistosoma mansoni serine/threonine protein kinase 0.022 0.1749 0.3013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0066
Onchocerca volvulus 0.0123 0.0821 0.2462
Schistosoma mansoni tyrosine kinase 0.0066 0.0276 0.0476
Trichomonas vaginalis STE family protein kinase 0.0077 0.0381 0.1439
Echinococcus multilocularis insulin receptor 0.0469 0.4126 0.4593
Trichomonas vaginalis AGC family protein kinase 0.0141 0.0995 0.4168
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0343 0.0591
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0156 0.1136 0.1232

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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