Detailed information for compound 1345655

Basic information

Technical information
  • TDR Targets ID: 1345655
  • Name: 7-methyl-5-(5-methylfuran-2-yl)-N-(2-methylph enyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine -6-carboxamide
  • MW: 381.448 | Formula: C20H19N3O3S
  • H donors: 1 H acceptors: 2 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(o1)C1C(=C(C)N=C2N1C(=O)CS2)C(=O)Nc1ccccc1C
  • InChi: 1S/C20H19N3O3S/c1-11-6-4-5-7-14(11)22-19(25)17-13(3)21-20-23(16(24)10-27-20)18(17)15-9-8-12(2)26-15/h4-9,18H,10H2,1-3H3,(H,22,25)
  • InChiKey: JJFSAPVMKYCMBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-methyl-5-(5-methyl-2-furyl)-N-(2-methylphenyl)-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide
  • 3-keto-7-methyl-5-(5-methyl-2-furyl)-N-(2-methylphenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide
  • 7-methyl-5-(5-methyl-2-furyl)-N-(2-methylphenyl)-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide
  • MLS000088678
  • SMR000072692

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aurora kinase 0.0129 0.1171 0.4337
Trichomonas vaginalis AGC family protein kinase 0.0256 0.2565 1
Entamoeba histolytica protein kinase, putative 0.0129 0.1171 0.4329
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0041 0.0203 0.0494
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.0174 0.0002
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0143 0.1322 0.1314
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0236 0.0387
Echinococcus multilocularis nervana 2 0.0125 0.113 0.286
Trypanosoma brucei cdc2-related kinase 3 0.0102 0.0875 0.2934
Schistosoma mansoni protein kinase 0.0047 0.0271 0.0667
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0413 0.1245
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0105 0.0913 0.0904
Trypanosoma cruzi casein kinase II, putative 0.0083 0.0668 0.2712
Trichomonas vaginalis STE family protein kinase 0.0069 0.0512 0.1448
Trypanosoma cruzi cdc2-related kinase 1 0.0102 0.0875 0.3827
Schistosoma mansoni unc-13 (munc13) 0.0036 0.0153 0.0365
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0174 0.0418
Echinococcus granulosus mitogen activated protein kinase 14 0.0143 0.1322 0.3366
Mycobacterium ulcerans beta-lactamase 0.0043 0.0236 0.5
Onchocerca volvulus 0.0112 0.0985 0.2912
Brugia malayi diacylglycerol kinase 0.0035 0.0139 0.0129
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0935 1 1
Schistosoma mansoni serine/threonine kinase 0.0127 0.1148 0.2904
Brugia malayi Protein kinase domain containing protein 0.0102 0.0875 0.0866
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0413 0.1245
Echinococcus multilocularis protein kinase c iota type 0.0245 0.2446 0.6218
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0129
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0036 0.0153 0.0389
Schistosoma mansoni hypothetical protein 0.0062 0.0437 0.1091
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0601 0.1509
Onchocerca volvulus 0.0296 0.2998 0.8929
Onchocerca volvulus 0.0043 0.0236 0.0675
Toxoplasma gondii histone kinase SNF1, putative 0.0038 0.0174 0.0147
Entamoeba histolytica casein kinase 1, putative 0.0053 0.0343 0.096
Trichomonas vaginalis AGC family protein kinase 0.0129 0.1171 0.4195
Schistosoma mansoni unc-13 (munc13) 0.0036 0.0153 0.0365
Schistosoma mansoni serine/threonine protein kinase 0.011 0.096 0.2425
Trypanosoma brucei protein kinase, putative 0.0112 0.0985 0.3391
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.0174 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0236 0.03
Echinococcus granulosus cyclin dependent kinase 0.0102 0.0875 0.2228
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0486 0.1343
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1148 0.4099
Trypanosoma brucei protein kinase, putative 0.0066 0.0486 0.1307
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0135 0.1242 0.3146
Leishmania major protein kinase A catalytic subunit isoform 2 0.0055 0.0367 0.1047
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.0174 0.0005
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0125 0.113 0.286
Onchocerca volvulus 0.0043 0.0236 0.0675
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0132 0.1208 0.1199
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0112 0.0984 0.3415
Trypanosoma cruzi cdc2-related kinase 1 0.0102 0.0875 0.3827
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Brugia malayi Casein kinase II, alpha chain 0.0083 0.0668 0.0659
Brugia malayi casein kinase 1, delta 0.0053 0.0343 0.0334
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0367 0.0912
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0142 0.131 0.3319
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0035 0.0139 0.0129
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0339 0.3477 0.3471
Schistosoma mansoni serine/threonine protein kinase 0.011 0.096 0.2425
Echinococcus multilocularis epidermal growth factor receptor 0.0066 0.0488 0.122
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0174 0.042
Echinococcus multilocularis mitogen activated protein kinase 3 0.0066 0.0486 0.1216
Trichomonas vaginalis CK1 family protein kinase 0.0053 0.0343 0.0746
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0055 0.0367 0.1094
Loa Loa (eye worm) hypothetical protein 0.0073 0.0555 0.0546
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0174 0.0418
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0053 0.0343 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Entamoeba histolytica diacylglycerol kinase, putative 0.0035 0.0139 0.0129
Loa Loa (eye worm) AGC/AKT protein kinase 0.0256 0.2565 0.2557
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0053 0.0343 0.0964
Echinococcus multilocularis epidermal growth factor receptor 0.0066 0.0488 0.122
Schistosoma mansoni tyrosine kinase 0.0139 0.1284 0.3251
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.011 0.096 0.2445
Brugia malayi P38 map kinase family protein 2 0.0143 0.1322 0.1314
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0236 0.03
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0129 0.1171 0.4329
Brugia malayi map kinase activated protein kinase protein 2 0.038 0.3928 0.3922
Schistosoma mansoni hypothetical protein 0.0062 0.0437 0.1091
Echinococcus multilocularis cyclin dependent kinase 1 0.0102 0.0875 0.2208
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2023 0.7742
Mycobacterium ulcerans lipase LipD 0.0043 0.0236 0.5
Loa Loa (eye worm) hypothetical protein 0.014 0.1298 0.1289
Brugia malayi Kinase associated domain 1 family protein 0.0062 0.0437 0.0428
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0055 0.0367 0.1727
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0067 0.0497 0.179
Entamoeba histolytica protein kinase, putative 0.0256 0.2565 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.0174 0.0005
Schistosoma mansoni serine/threonine-protein kinase 0.0144 0.134 0.3395
Entamoeba histolytica protein kinase, putative 0.0039 0.0188 0.033
Brugia malayi Protein kinase c protein 2 0.0091 0.0757 0.0747
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0177 0.1695 0.4301
Brugia malayi serine/threonine-protein kinase plk-2 0.0207 0.2023 0.2015
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0212 0.208 0.5284
Onchocerca volvulus 0.0121 0.109 0.3226
Schistosoma mansoni hypothetical protein 0.0032 0.0107 0.0249
Trypanosoma cruzi cdc2-related kinase 3 0.0102 0.0875 0.3827
Brugia malayi serine/threonine-protein kinase PAK 7 0.0216 0.2131 0.2123
Brugia malayi Protein kinase domain containing protein 0.0127 0.1148 0.1139
Schistosoma mansoni ephrin receptor 0.0072 0.0545 0.1367
Loa Loa (eye worm) hypothetical protein 0.0117 0.1044 0.1035
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0174 0.0444
Brugia malayi Cam kinase protein 1 0.0038 0.0174 0.0165
Schistosoma mansoni ste20-related kinase 0.0189 0.1832 0.4651
Schistosoma mansoni tyrosine kinase 0.0066 0.0488 0.122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0165
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0053 0.0343 0.0334
Brugia malayi protein unc-22 0.0023 0.001 0.0000064467
Loa Loa (eye worm) AUR protein kinase 0.0129 0.1171 0.1162
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0026 0.0044 0.0111
Echinococcus granulosus RNA directed DNA polymerase 0.004 0.0199 0.0507
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Giardia lamblia Kinase, CMGC GSK 0.0112 0.0985 0.4385
Echinococcus multilocularis cyclin dependent kinase 1 0.0102 0.0875 0.2208
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Onchocerca volvulus 0.0117 0.1044 0.3089
Trypanosoma cruzi casein kinase, putative 0.0053 0.0343 0.0964
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0875 0.2963
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0367 0.0912
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Entamoeba histolytica casein kinase, putative 0.0083 0.0668 0.2282
Toxoplasma gondii AGC kinase 0.0252 0.2519 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0236 0.0408
Echinococcus granulosus casein kinase I delta 0.0053 0.0343 0.0874
Loa Loa (eye worm) hypothetical protein 0.0083 0.0664 0.0655
Echinococcus multilocularis serine:threonine protein kinase 38 0.0127 0.1148 0.2904
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0236 0.0554
Brugia malayi cell division control protein 2 homolog 0.0102 0.0875 0.0866
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0236 0.03
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0055 0.0367 0.096
Echinococcus multilocularis rac serine:threonine kinase 0.0144 0.134 0.3395
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0112 0.0985 0.2507
Brugia malayi ephrin receptor 1 precursor 0.0037 0.017 0.0161
Entamoeba histolytica PH domain containing protein kinase, putative 0.0144 0.134 0.5018
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0032 0.0107 0.0273
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0032 0.0107 0.0098
Echinococcus multilocularis Diacylglycerol kinase theta 0.0035 0.0139 0.0329
Echinococcus granulosus rho-associated protein kinase 1 0.0311 0.3162 0.8051
Schistosoma mansoni protein kinase 0.0069 0.0512 0.1281
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0367 0.0847
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1148 0.2904
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0164 0.0393
Trypanosoma cruzi aurora B kinase, putative 0.0129 0.1171 0.5418
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0035 0.0139 0.0129
Echinococcus granulosus calcium dependent protein kinase 0.0023 0.001 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0119 0.1067 0.3763
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0601 0.1822
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0236 0.5
Schistosoma mansoni protein kinase 0.0083 0.0668 0.168
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0226
Echinococcus granulosus ephrin type A receptor 4 A 0.0072 0.0545 0.1389
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0236 0.03
Schistosoma mansoni protein kinase 0.0069 0.0512 0.1281
Plasmodium falciparum casein kinase 1 0.0053 0.0343 0.1511
Entamoeba histolytica protein kinase, putative 0.0053 0.0344 0.0962
Echinococcus granulosus serine:threonine protein kinase N2 0.0127 0.1148 0.2922
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0367 0.0935
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0067 0.0497 0.135
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Echinococcus multilocularis serine threonine protein kinase 0.0168 0.1601 0.4062
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0601 0.1509
Schistosoma mansoni protein kinase C mu 0.0035 0.0139 0.0329
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0367 0.0912
Loa Loa (eye worm) AUR protein kinase 0.0129 0.1171 0.1162
Loa Loa (eye worm) hypothetical protein 0.0065 0.0469 0.046
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0985 0.3418
Echinococcus multilocularis protein kinase c eta type 0.0035 0.0139 0.0329
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0144 0.134 0.6329
Brugia malayi diacylglycerol kinase 0.0035 0.0139 0.0129
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0177 0.1695 0.4315
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.1148 0.2904
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0112 0.0985 0.0976
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0875 0.2208
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0306 0.3115 0.3109
Onchocerca volvulus 0.0083 0.0664 0.1955
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0236 0.0601
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0226
Brugia malayi serine/threonine-protein kinase 6 0.0129 0.1171 0.1162
Trichomonas vaginalis STE family protein kinase 0.0119 0.1067 0.3763
Echinococcus granulosus serine:threonine protein kinase 3 0.0241 0.2405 0.6123
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.014 0.1295 1
Entamoeba histolytica protein kinase, putative 0.0047 0.0271 0.0668
Echinococcus multilocularis mitogen activated protein kinase 14 0.0143 0.1322 0.3349
Echinococcus multilocularis protein kinase shaggy 0.0112 0.0985 0.2488
Echinococcus multilocularis protein kinase c epsilon type 0.0163 0.1541 0.3908
Brugia malayi Protein kinase domain 0.0069 0.0512 0.0502
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0241 0.2405 0.2398
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0069 0.0512 0.1281
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0668 0.21
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0143 0.1322 0.6211
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0125 0.113 0.2878
Brugia malayi Ras association domain family 1 isoform A 0.0035 0.0139 0.0129
Entamoeba histolytica protein kinase, putative 0.0129 0.1171 0.4329
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0985 0.3418
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0985 0.357
Loa Loa (eye worm) raf kinase 0.0035 0.0139 0.0129
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0053 0.0343 0.0851
Entamoeba histolytica hypothetical protein 0.0105 0.0913 0.328
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0037 0.0164 0.0154
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0203 0.1981 0.503
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0343 0.0851
Trichomonas vaginalis STE family protein kinase 0.0047 0.0271 0.0447
Echinococcus multilocularis serine:threonine protein kinase 0.0097 0.0823 0.2076
Echinococcus multilocularis myosin iiia 0.0067 0.0497 0.1242
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.2023 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0236 0.0577
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0112 0.0985 0.2488
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0066 0.0486 0.146
Schistosoma mansoni protein kinase 0.0179 0.1723 0.4373
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0183 0.0443
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0174 0.042
Trichomonas vaginalis STE family protein kinase 0.0069 0.0512 0.1448
Schistosoma mansoni serine/threonine protein kinase 0.038 0.3928 1
Brugia malayi Protein kinase domain containing protein 0.0177 0.1695 0.1687
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0207 0.2023 0.2015
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0102 0.0875 0.0866
Echinococcus granulosus aurora kinase A 0.0129 0.1171 0.2981
Plasmodium vivax protein kinase Crk2 0.0102 0.0875 0.6259
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0069 0.0512 0.1303
Giardia lamblia Kinase, NEK 0.0119 0.1067 0.4833
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0367 0.0935
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0875 0.2963
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0112 0.0985 0.0976
Toxoplasma gondii casein kinase I 0.0053 0.0343 0.0858
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1981 0.503
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0159 0.1501 0.3821
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0143 0.1322 0.4803
Leishmania major protein kinase, putative 0.0067 0.0497 0.1746
Loa Loa (eye worm) hypothetical protein 0.0083 0.0664 0.0655
Entamoeba histolytica hypothetical protein 0.0035 0.0139 0.0129
Entamoeba histolytica cell division protein kinase 2, putative 0.0102 0.0875 0.3125
Echinococcus multilocularis cyclin dependent kinase 0.0102 0.0875 0.2208
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.1784 0.4527
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0026 0.0044 0.0111
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0102 0.0875 0.3794
Trichomonas vaginalis STE family protein kinase 0.0069 0.0512 0.1448
Brugia malayi beta-lactamase family protein 0.0043 0.0236 0.0226
Trypanosoma cruzi casein kinase, putative 0.0053 0.0343 0.0964
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.014 0.1295 0.3279
Echinococcus granulosus epidermal growth factor receptor 0.0066 0.0488 0.1242
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0032 0.0107 0.0249
Echinococcus multilocularis calcium activated potassium channel 0.0077 0.0601 0.1509
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0119 0.1067 0.7974
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.1242 0.3146
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2803 1
Echinococcus granulosus casein kinase i 0.0053 0.0343 0.0874
Trichomonas vaginalis AGC family protein kinase 0.0129 0.1171 0.4195
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0053 0.0344 0.0875
Echinococcus multilocularis N chimaerin 0.0035 0.0139 0.0329
Plasmodium falciparum serine/threonine protein kinase, putative 0.0129 0.1171 0.8898
Loa Loa (eye worm) hypothetical protein 0.009 0.0749 0.074
Echinococcus multilocularis mitogen activated protein kinase 11 0.0143 0.1322 0.3349
Brugia malayi P21-Rho-binding domain containing protein 0.0032 0.0107 0.0098
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0035 0.0139 0.0329
Brugia malayi Protein kinase domain containing protein 0.0185 0.1784 0.1776
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0026 0.0044 0.0086
Echinococcus multilocularis serine:threonine protein kinase 3 0.0241 0.2405 0.6114
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0159 0.1501 0.3821
Trypanosoma brucei rac serine-threonine kinase, putative 0.0256 0.2565 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0069 0.0512 0.1281
Trichomonas vaginalis AGC family protein kinase 0.0256 0.2565 1
Brugia malayi protein kinase C3,putative 0.0133 0.1222 0.1213
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1148 0.2904
Plasmodium falciparum protein kinase 5 0.0102 0.0875 0.6259
Echinococcus granulosus epidermal growth factor receptor 0.0066 0.0488 0.1242
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0127 0.1148 0.2922
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0038 0.0174 0.0164
Schistosoma mansoni serine/threonine kinase 0.0077 0.0601 0.1509
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0119 0.1067 0.3901
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.0174 0.0005
Leishmania major casein kinase, putative 0.0053 0.0343 0.0916
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Echinococcus multilocularis nervana 2 0.0125 0.113 0.286
Loa Loa (eye worm) hypothetical protein 0.009 0.0749 0.074
Loa Loa (eye worm) AGC/PKA protein kinase 0.0055 0.0367 0.0358
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0236 0.0577
Echinococcus granulosus titin 0.0023 0.001 0.0025
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0102 0.0875 0.3094
Echinococcus granulosus roundabout 2 0.0024 0.0026 0.0065
Echinococcus granulosus casein kinase I alpha 0.0053 0.0343 0.0874
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0486 0.1216
Echinococcus multilocularis unc 13 (munc13) 0.0036 0.0153 0.0365
Entamoeba histolytica cell division protein kinase 2, putative 0.0102 0.0875 0.3125
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0129 0.1171 0.2963
Brugia malayi Immunoglobulin I-set domain containing protein 0.0339 0.3477 0.3471
Giardia lamblia Kinase, AGC PKA 0.0055 0.0367 0.1047
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0668 0.21
Entamoeba histolytica p21-activated kinase 0.0073 0.0557 0.1832
Giardia lamblia Kinase, CMGC MAPK 0.0066 0.0486 0.1691
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0236 0.0226
Onchocerca volvulus Serine\/threonine kinase homolog 0.0207 0.2023 0.6014
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0959 0.3313
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0055 0.0367 0.1094
Schistosoma mansoni hypothetical protein 0.0032 0.0107 0.0249
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.014 0.1295 0.3296
Echinococcus granulosus Rac GTPase activating protein 1 0.0035 0.0139 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0348 0.0765
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0159 0.1501 0.3805
Echinococcus granulosus serine threonine protein kinase nrc 0.014 0.1295 0.3296
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0038 0.0174 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2023 0.7742
Schistosoma mansoni serine/threonine protein kinase 0.0311 0.3162 0.8046
Leishmania major casein kinase II, putative 0.0083 0.0668 0.2673
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0069 0.0512 0.1303
Trypanosoma cruzi casein kinase, putative 0.0053 0.0343 0.0964
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0066 0.0486 0.0477
Brugia malayi RhoGAP domain containing protein 0.0035 0.0139 0.0129
Entamoeba histolytica serine/threonine protein kinase, putative 0.0038 0.0174 0.0271
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0212 0.208 0.5296
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0035 0.0139 0.0354
Echinococcus granulosus protein kinase c iota type 0.0245 0.2446 0.6228
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0236 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0215 0.0524
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0668 0.21
Brugia malayi Variant SH3 domain containing protein 0.0035 0.0139 0.0129
Giardia lamblia Kinase, PLK 0.0207 0.2023 1
Loa Loa (eye worm) hypothetical protein 0.014 0.1298 0.1289
Brugia malayi RhoGEF domain containing protein 0.0035 0.0139 0.0129
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0055 0.0367 0.0809
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0053 0.0343 0.0334
Plasmodium vivax unspecified product 0.0083 0.0668 0.4409
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0159 0.1501 0.3805
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0185 0.1783 0.454
Brugia malayi putative serine/threonine kinase SADA gamma 0.0038 0.0174 0.0164
Echinococcus multilocularis PAK box P21 Rho binding 0.0047 0.0271 0.0667
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0097 0.0823 0.0814
Entamoeba histolytica protein kinase, putative 0.0112 0.0985 0.357
Trichomonas vaginalis CK1 family protein kinase 0.0053 0.0343 0.0746
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0486 0.1343
Schistosoma mansoni hypothetical protein 0.0032 0.0107 0.0249
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0668 0.21
Echinococcus multilocularis ephrin type A receptor 4 A 0.0072 0.0545 0.1367
Loa Loa (eye worm) hypothetical protein 0.0121 0.109 0.1081
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0055 0.0367 0.1094
Echinococcus multilocularis casein kinase i 0.0053 0.0343 0.0851
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0067 0.0497 0.1585
Echinococcus granulosus serine:threonine protein kinase 0.0097 0.0823 0.2096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0367 0.0358
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0055 0.0367 0.1727
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.011 0.096 0.2425
Echinococcus granulosus casein kinase I alpha 0.0053 0.0343 0.0874
Echinococcus multilocularis rho associated protein kinase 0.0311 0.3162 0.8046
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0055 0.0367 0.0809
Entamoeba histolytica casein kinase, putative 0.0053 0.0343 0.096
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0486 0.1735
Onchocerca volvulus 0.0036 0.0153 0.0427
Trichomonas vaginalis AGC family protein kinase 0.0256 0.2565 1
Echinococcus granulosus serine:threonine kinase SAD 1 0.0038 0.0174 0.0443
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0129
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.1148 0.2904
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0913 0.4031
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0105 0.0913 0.4
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0041 0.0203 0.0518
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0177 0.1695 0.1687
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.1695 0.4301
Loa Loa (eye worm) AGC/PKN protein kinase 0.0127 0.1148 0.1139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0236 0.0577
Loa Loa (eye worm) RasGEF domain-containing protein 0.0035 0.0139 0.0129
Entamoeba histolytica protein kinase, putative 0.0105 0.0913 0.328
Giardia lamblia Kinase, NEK 0.0119 0.1067 0.4833
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0129
Brugia malayi Protein kinase domain containing protein 0.0139 0.1284 0.1275
Entamoeba histolytica protein kinase, putative 0.0127 0.1148 0.4235
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0102 0.0875 0.0866
Leishmania major hypothetical protein, conserved 0.0043 0.0236 0.0336
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0135 0.1242 0.3163
Schistosoma mansoni protein kinase 0.0038 0.0174 0.042
Trichomonas vaginalis AGC family protein kinase 0.0256 0.2565 1
Entamoeba histolytica protein kinase, putative 0.0051 0.0317 0.0854
Echinococcus granulosus calcium activated potassium channel 0.0077 0.0601 0.1531
Loa Loa (eye worm) hypothetical protein 0.0033 0.0121 0.0111
Echinococcus multilocularis roundabout 2 0.0024 0.0026 0.004
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0913 0.4031
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0486 0.1343
Mycobacterium leprae Probable lipase LipE 0.0043 0.0236 0.5
Entamoeba histolytica serine/threonine protein kinase, putative 0.0207 0.2023 0.7795
Onchocerca volvulus 0.0038 0.0179 0.0506
Toxoplasma gondii CMGC kinase, CK2 family 0.0083 0.0668 0.2223
Echinococcus granulosus Glutaredoxin protein 5 0.0125 0.113 0.2878
Toxoplasma gondii AGC kinase 0.0055 0.0367 0.096
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Brugia malayi RhoGAP domain containing protein 0.0035 0.0139 0.0129
Echinococcus multilocularis mitogen activated protein kinase 0.0066 0.0486 0.1216
Onchocerca volvulus 0.014 0.1298 0.3849
Entamoeba histolytica protein kinase 2, putative 0.014 0.1295 0.4831
Trypanosoma cruzi casein kinase, putative 0.0053 0.0343 0.0964
Schistosoma mansoni vav2 0.0039 0.0185 0.0446
Schistosoma mansoni protein kinase 0.0038 0.0174 0.042
Brugia malayi Pleckstrin Homology Domain 0.0039 0.0185 0.0175
Brugia malayi Protein kinase domain containing protein 0.0256 0.2565 0.2557
Echinococcus multilocularis calcium dependent protein kinase 0.0023 0.001 0.0001
Echinococcus multilocularis casein kinase I delta 0.0053 0.0343 0.0851
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.2023 0.5137
Echinococcus granulosus insulin receptor 0.0139 0.1284 0.3268
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0143 0.1322 0.6231
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.2023 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0236 0.5
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.0174 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2023 0.7742
Loa Loa (eye worm) hypothetical protein 0.0054 0.0348 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0344 0.0852
Brugia malayi serine/threonine protein kinase 6 0.0129 0.1171 0.1162
Schistosoma mansoni atypical protein kinase C 0.0251 0.2514 0.639
Echinococcus granulosus casein kinase I alpha 0.0053 0.0343 0.0874
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.0913 0.328
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2023 0.7742
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0112 0.0985 0.2488
Trichomonas vaginalis CK1 family protein kinase 0.0053 0.0343 0.0746
Schistosoma mansoni protein kinase C 0.0036 0.0153 0.0365
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0207 0.2023 0.5137
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.0174 0.0005
Entamoeba histolytica protein kinase, putative 0.0105 0.0913 0.328
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0174 0.042
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.038 0.3928 0.3922
Brugia malayi Protein kinase domain containing protein 0.008 0.0632 0.0622
Echinococcus granulosus titin 0.0023 0.001 0.0025
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0069 0.0512 0.1281
Echinococcus granulosus mitogen activated protein kinase 0.0066 0.0486 0.1238
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0104 0.0902 0.3937
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Schistosoma mansoni tyrosine kinase 0.006 0.0412 0.1026
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2023 0.7742
Schistosoma mansoni diacylglycerol kinase theta 0.0035 0.0139 0.0329
Giardia lamblia Kinase, CMGC GSK 0.0112 0.0985 0.4385
Trichomonas vaginalis AGC family protein kinase 0.0129 0.1171 0.4195
Brugia malayi beta-lactamase family protein 0.0043 0.0236 0.0226
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0185 0.1783 0.4526
Loa Loa (eye worm) TK/INSR protein kinase 0.0139 0.1284 0.1275
Schistosoma mansoni protein kinase 0.0129 0.1171 0.2963
Trypanosoma cruzi rac serine-threonine kinase, putative 0.014 0.1295 0.6082
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0668 0.21
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0177 0.1695 0.1687
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0127 0.1148 0.2904
Echinococcus multilocularis dual specificity 0.0105 0.0913 0.2306
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0212 0.208 0.2073
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0179 0.1723 0.4387
Echinococcus multilocularis mitogen activated protein kinase 14 0.0143 0.1322 0.3349
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0038 0.0174 0.0418
Plasmodium vivax glycogen synthase kinase 3, putative 0.0112 0.0985 0.7235
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0143 0.1322 0.6231
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1069
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0177 0.1695 0.1687
Schistosoma mansoni tyrosine kinase 0.0139 0.1284 0.3251
Brugia malayi probable protein kinase 0.0026 0.0044 0.0034
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0174 0.0444
Echinococcus granulosus casein kinase ii subunit alpha 0.0083 0.0668 0.1701
Plasmodium falciparum casein kinase 2, alpha subunit 0.0083 0.0668 0.4409
Echinococcus multilocularis serine:threonine protein kinase 0.0097 0.0823 0.2076
Brugia malayi casein kinase I 0.0053 0.0343 0.0334
Brugia malayi ribosomal protein S6 kinase alpha 3 0.01 0.0856 0.0847
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0129 0.1171 0.4329
Schistosoma mansoni tyrosine kinase 0.006 0.0412 0.1026
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0023 0.001 0.0000064467
Trichomonas vaginalis AGC family protein kinase 0.0256 0.2565 1
Schistosoma mansoni rac gtpase activating protein 0.0035 0.0139 0.0329
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0038 0.0179 0.0081
Entamoeba histolytica protein kinase domain containing protein 0.0129 0.1171 0.4329
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0032 0.0107 0.0249
Echinococcus multilocularis mitogen activated protein kinase 11 0.0143 0.1322 0.3349
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0055 0.0367 0.0809
Giardia lamblia Kinase, STE STE20 0.0067 0.0497 0.1746
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Giardia lamblia Kinase, CMGC CK2 0.0083 0.0668 0.2673
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0174 0.042
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0066 0.0486 0.1735
Echinococcus granulosus protein kinase c epsilon type 0.0163 0.1541 0.3924
Trichomonas vaginalis STE family protein kinase 0.0069 0.0512 0.1448
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.0174 0.0165
Onchocerca volvulus 0.0043 0.0236 0.0675
Trypanosoma brucei cdc2-related kinase 1 0.0102 0.0875 0.2934
Echinococcus multilocularis myotubularin protein 13 0.0039 0.0185 0.0446
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0112 0.0985 0.3553
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0174 0.0444
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.003 0.0086 0.0076
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0236 0.026
Schistosoma mansoni protein kinase 0.0026 0.0044 0.0086
Echinococcus multilocularis aurora kinase A 0.0129 0.1171 0.2963
Loa Loa (eye worm) hypothetical protein 0.0036 0.0153 0.0143
Echinococcus multilocularis casein kinase I alpha 0.0053 0.0343 0.0851
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0226
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0236 0.5
Loa Loa (eye worm) AGC/PKA protein kinase 0.0055 0.0367 0.0358
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0105 0.0913 0.3093
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0127 0.1148 0.1139
Brugia malayi Protein kinase domain containing protein 0.0026 0.0044 0.0034
Entamoeba histolytica protein kinase, putative 0.0252 0.2519 0.9814
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0236 0.03
Loa Loa (eye worm) AUR protein kinase 0.0129 0.1171 0.1162
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0069 0.0512 0.1303
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0132 0.1208 0.1199
Echinococcus multilocularis casein kinase I delta 0.0053 0.0343 0.0851
Echinococcus multilocularis insulin receptor 0.0139 0.1284 0.3251
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0053 0.0344 0.0852
Entamoeba histolytica protein kinase, putative 0.0256 0.2565 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0129 0.1171 0.4329
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.0174 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0367 0.0912
Brugia malayi intracellular kinase 0.0112 0.0985 0.0976
Echinococcus granulosus serine:threonine protein kinase 0.0097 0.0823 0.2096
Onchocerca volvulus 0.0053 0.0343 0.0996
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0959 0.3313
Brugia malayi Protein kinase domain containing protein 0.0127 0.1148 0.1139
Brugia malayi Hr1 repeat family protein 0.0127 0.1148 0.1139
Brugia malayi Furin-like cysteine rich region family protein 0.0066 0.0488 0.0479
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0035 0.0139 0.0329
Echinococcus granulosus protein kinase shaggy 0.0112 0.0985 0.2507
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0129
Schistosoma mansoni protein kinase 0.0032 0.0107 0.0249
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0066 0.0486 0.1691
Schistosoma mansoni protein kinase 0.0053 0.0343 0.0851
Echinococcus granulosus Protein kinase C brain isozyme 0.0203 0.1981 0.5043
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.0174 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0226
Echinococcus granulosus protein kinase C gamma type 0.0168 0.1601 0.4077
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1981 0.503
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0098 0.0828 0.0819
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0102 0.0875 0.2228
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0236 0.0387
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0185 0.1784 0.1776
Schistosoma mansoni serine/threonine-protein kinase 0.0144 0.134 0.3395
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0053 0.0343 0.0874
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0329
Trichomonas vaginalis AGC family protein kinase 0.0129 0.1171 0.4195
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0174 0.0418
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0038 0.0174 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0367 0.0912
Onchocerca volvulus 0.0316 0.3221 0.9594
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0026 0.0044 0.0086
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0367 0.0912
Echinococcus granulosus nervana 2 0.0125 0.113 0.2878
Brugia malayi p70 ribosomal S6 kinase beta 0.0252 0.2519 0.2511
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0127 0.1148 0.2922
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0252 0.2519 0.2511
Trypanosoma brucei casein kinase I, isoform 2 0.0053 0.0343 0.0708
Schistosoma mansoni diacylglycerol kinase theta 0.0035 0.0139 0.0329
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0913 0.2306
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0056 0.0377 0.0368
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0112 0.0985 0.4385
Loa Loa (eye worm) AGC/NDR protein kinase 0.0127 0.1148 0.1139
Giardia lamblia Kinase, AGC PKA 0.014 0.1295 0.6062
Trypanosoma cruzi Protein kinase B 0.0144 0.134 0.6329
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0216 0.2131 0.2123
Echinococcus granulosus PAK box P21 Rho binding 0.0032 0.0107 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0256 0.2565 1
Entamoeba histolytica protein kinase, putative 0.0051 0.0317 0.0854
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.1501 0.3805
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.208 0.5284
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1148 0.4099
Brugia malayi Temporarily assigned gene name protein 59 0.0131 0.119 0.1181
Schistosoma mansoni protein kinase 0.0026 0.0044 0.0086
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0067 0.0497 0.1585
Brugia malayi protein kinase C II. 0.0163 0.1541 0.1533
Entamoeba histolytica PH domain containing protein kinase, putative 0.0144 0.134 0.5018
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0036 0.0153 0.0365
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0102 0.0875 0.3794
Schistosoma mansoni tyrosine kinase 0.0039 0.0183 0.0443
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.0174 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0579 0.0569
Brugia malayi Protein kinase domain containing protein 0.0105 0.0913 0.0904
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0215 0.0524
Brugia malayi WH1 domain containing protein 0.0032 0.0107 0.0098
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0207 0.2023 0.5149
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0985 0.357
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0179 0.1723 0.4373
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0112 0.0985 0.4415
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0037 0.0164 0.0154
Echinococcus multilocularis casein kinase I alpha 0.0053 0.0343 0.0851
Loa Loa (eye worm) TK/EPH protein kinase 0.0089 0.074 0.0731
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0174 0.042
Brugia malayi P21-Rho-binding domain containing protein 0.0032 0.0107 0.0098
Echinococcus multilocularis casein kinase I alpha 0.0053 0.0343 0.0851
Brugia malayi serine/threonine kinase 12 0.0129 0.1171 0.1162
Echinococcus granulosus Diacylglycerol kinase theta 0.0035 0.0139 0.0354
Mycobacterium ulcerans hypothetical protein 0.0043 0.0236 0.5
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0035 0.0139 0.0329
Schistosoma mansoni protein kinase 0.0038 0.0174 0.042
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0067 0.0497 0.179
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.0174 0.0444
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0163 0.1541 0.1533
Brugia malayi STE20-like kinase MST 0.0241 0.2405 0.2398
Loa Loa (eye worm) hypothetical protein 0.0039 0.0185 0.0175
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0066 0.0486 0.1735
Entamoeba histolytica diacylglycerol kinase, putative 0.0035 0.0139 0.0129
Giardia lamblia Kinase, STE STE20 0.0069 0.0512 0.1827
Giardia lamblia Kinase, CMGC CDK 0.0102 0.0875 0.3794
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0207 0.2023 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0226
Trypanosoma brucei Casein kinase II 0.0083 0.0668 0.2067
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.1541 0.3908
Echinococcus granulosus nervana 2 0.0125 0.113 0.2878
Giardia lamblia Kinase, CMGC CDK 0.0102 0.0875 0.3794
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0164 0.0393
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0066 0.0486 0.1691
Trypanosoma cruzi casein kinase, putative 0.0053 0.0343 0.0964
Leishmania major protein kinase A catalytic subunit 0.0055 0.0367 0.1047
Schistosoma mansoni tyrosine kinase 0.0066 0.0488 0.122
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.014 0.129 0.1281
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0174 0.0005
Loa Loa (eye worm) CAMK protein kinase 0.0023 0.001 0.0000064467
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0077 0.0601 0.0592
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0066 0.0486 0.1307
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2023 0.7742
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.014 0.1295 1
Echinococcus granulosus unc 13 munc13 0.0036 0.0153 0.0389
Echinococcus granulosus MAP kinase activated protein kinase 2 0.038 0.3928 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.001 0.0000064467
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1148 0.2904
Schistosoma mansoni protein kinase C mu 0.0132 0.1208 0.3057
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0486 0.1343
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0174 0.0418
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.0174 0.0165
Trichomonas vaginalis esterase, putative 0.0043 0.0236 0.03
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0066 0.0488 0.1242
Echinococcus granulosus protein kinase c eta type 0.0035 0.0139 0.0354
Giardia lamblia Kinase, AGC AKT 0.01 0.0856 0.369
Echinococcus granulosus mitogen activated protein kinase 3 0.0066 0.0486 0.1238
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0174 0.0164
Toxoplasma gondii AGC kinase 0.0055 0.0367 0.096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0129
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0226
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0035 0.0139 0.0129
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0668 0.21
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0037 0.0164 0.0154
Brugia malayi Protein kinase domain containing protein 0.017 0.1622 0.1613
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0668 0.21
Trichomonas vaginalis STE family protein kinase 0.0067 0.0497 0.1386
Echinococcus multilocularis Glutaredoxin protein 5 0.0125 0.113 0.286
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0055 0.0367 0.0358
Echinococcus granulosus serine/threonine protein kinase 0.0144 0.134 0.3412
Onchocerca volvulus 0.0065 0.0469 0.1372
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0129
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0367 0.0935
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0875 0.2963
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0135 0.1242 0.1234
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.0174 0.0165
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.0174 0.0149
Loa Loa (eye worm) beta-lactamase 0.0043 0.0236 0.0226
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0083 0.0668 0.0659
Leishmania major protein kinase A catalytic subunit isoform 1 0.0055 0.0367 0.1047
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0129 0.1171 0.8898
Trypanosoma brucei polo-like protein kinase 0.0207 0.2023 0.7733
Leishmania major protein kinase, putative 0.0038 0.0174 0.0003
Schistosoma mansoni protein kinase 0.0179 0.1723 0.4373
Echinococcus granulosus NDR protein kinase 0.0127 0.1148 0.2922
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0026 0.0044 0.0034
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0127 0.1148 0.2904
Echinococcus multilocularis RNA directed DNA polymerase 0.004 0.0199 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.1501 0.3805
Echinococcus granulosus cyclin dependent kinase 5 0.0102 0.0875 0.2228
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1171 0.2963
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2023 0.7742
Echinococcus granulosus casein kinase I delta 0.0053 0.0343 0.0874
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0135 0.1242 0.1234
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0486 0.1735
Echinococcus granulosus myotubularin protein 13 0.0039 0.0185 0.047
Brugia malayi C1-like domain containing protein 0.0132 0.1208 0.1199
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.0174 0.0005
Echinococcus granulosus dual specificity 0.0105 0.0913 0.2325
Echinococcus multilocularis cyclin dependent kinase 5 0.0102 0.0875 0.2208
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.038 0.3928 1
Echinococcus multilocularis Rac GTPase activating protein 1 0.0035 0.0139 0.0329
Loa Loa (eye worm) TK/EGFR protein kinase 0.0066 0.0488 0.0479
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0668 0.2282
Schistosoma mansoni kinase 0.0112 0.0987 0.2494
Echinococcus granulosus cyclin dependent kinase 1 0.0102 0.0875 0.2228
Trypanosoma cruzi cdc2-related kinase 3 0.0102 0.0875 0.3827
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0367 0.0912
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0875 0.2208
Loa Loa (eye worm) hypothetical protein 0.0087 0.0711 0.0702
Leishmania major protein kinase, putative 0.0129 0.1171 0.5393
Loa Loa (eye worm) hypothetical protein 0.0062 0.0437 0.0428
Plasmodium falciparum glycogen synthase kinase 3 0.0112 0.0985 0.7235
Entamoeba histolytica protein kinase, putative 0.0069 0.0512 0.1646
Trypanosoma brucei aurora B kinase 0.0129 0.1171 0.4171
Entamoeba histolytica protein kinase, putative 0.0053 0.0344 0.0962
Brugia malayi Protein kinase domain containing protein 0.0097 0.0823 0.0814
Echinococcus granulosus twitchin 0.003 0.0087 0.0221
Loa Loa (eye worm) hypothetical protein 0.0175 0.1677 0.1669
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0215 0.0548
Loa Loa (eye worm) hypothetical protein 0.014 0.1298 0.1289
Onchocerca volvulus 0.0311 0.3162 0.9419
Plasmodium vivax casein kinase 1, putative 0.0053 0.0343 0.1511
Giardia lamblia Aurora kinase 0.0129 0.1171 0.5393
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0823 0.2746
Brugia malayi Protein kinase domain containing protein 0.0077 0.0601 0.0592
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0055 0.0367 0.1094
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0129 0.1171 0.2981
Echinococcus granulosus N chimaerin 0.0035 0.0139 0.0354
Echinococcus multilocularis hypothetical protein 0.0062 0.0437 0.1091
Plasmodium falciparum NIMA related kinase 1 0.0119 0.1067 0.7974
Brugia malayi beta-lactamase 0.0043 0.0236 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0256 0.2565 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0823 0.0814
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.004 0.0199 0.0483
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0174 0.0041
Onchocerca volvulus Tyrosine kinase homolog 0.0328 0.3357 1
Echinococcus multilocularis PAK box P21 Rho binding 0.0032 0.0107 0.0249
Giardia lamblia Kinase, CK1 Casein kinase 0.0053 0.0343 0.0916
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0032 0.0107 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0131 0.1194 0.4289
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0142 0.131 0.3336
Echinococcus multilocularis casein kinase ii subunit alpha 0.0083 0.0668 0.168
Echinococcus granulosus mitogen activated protein kinase 11 0.0143 0.1322 0.3366
Entamoeba histolytica protein kinase , putative 0.0129 0.1171 0.4329
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0102 0.0875 0.0866
Schistosoma mansoni tyrosine kinase 0.0066 0.0488 0.122
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1148 0.4099
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0601 0.1509
Entamoeba histolytica protein kinase, putative 0.0038 0.0174 0.0273
Giardia lamblia Kinase, NEK 0.0119 0.1067 0.4833
Loa Loa (eye worm) hypothetical protein 0.0267 0.2686 0.2679
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0083 0.0668 0.4409
Brugia malayi MAP kinase sur-1 0.0066 0.0486 0.0477
Loa Loa (eye worm) hypothetical protein 0.004 0.0199 0.0189
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0177 0.1695 0.5035
Schistosoma mansoni tyrosine kinase 0.006 0.0412 0.1026

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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