Detailed information for compound 135483

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.451 | Formula: C19H28N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)C1CC2C(C1)CCC2
  • InChi: 1S/C19H28N4O2/c1-3-8-22-17-15(18(24)23(9-4-2)19(22)25)20-16(21-17)14-10-12-6-5-7-13(12)11-14/h12-14H,3-11H2,1-2H3,(H,20,21)
  • InChiKey: ZRCSOMMFTYAFJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References
Cavia porcellus Adenosine A1 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 23.1 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 356 aa 23.9 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2 receptor   410 aa 346 aa 28.3 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 309 aa 21.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 315 aa 21.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2 receptor   410 aa 340 aa 27.9 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 337 aa 23.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2 receptor   410 aa 399 aa 28.1 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2 receptor   410 aa 366 aa 25.4 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 0.0014 0.0006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0362 0.0759 0.1418
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0101 0.018 0.0332
Echinococcus granulosus sodium and chloride dependent glycine 0.0412 0.087 0.0863
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis allatostatin A receptor 0.0101 0.018 0.0172
Schistosoma mansoni phosphoglucomutase 0.0026 0.0013 0.0005
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0035 0.0758
Echinococcus multilocularis potassium voltage gated channel protein 0.0286 0.0591 0.0583
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0032 0.0023
Schistosoma mansoni amine GPCR 0.0101 0.018 0.0172
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0018 0.1394
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0101 0.018 0.0172
Echinococcus granulosus neuropeptide receptor A26 0.0101 0.018 0.0172
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0049 0.0065 0.0116
Echinococcus multilocularis G protein coupled receptor 139 0.0101 0.018 0.0172
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0022 0.0016
Plasmodium vivax amine transporter, putative 0.0412 0.087 1
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Brugia malayi follicle stimulating hormone receptor 0.0101 0.018 0.0322
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.001
Loa Loa (eye worm) hypothetical protein 0.052 0.1111 0.2077
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0101 0.018 0.0172
Echinococcus granulosus FTZ F1 alpha 0.003 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0018 0.1394
Trypanosoma brucei RNA helicase, putative 0.0096 0.017 0.0335
Brugia malayi Importin beta-1 subunit 0.0034 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.018 0.0172
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0028
Schistosoma mansoni hypothetical protein 0.0101 0.018 0.0172
Schistosoma mansoni phosphoglucomutase 0.0026 0.0013 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0022 0.0036
Loa Loa (eye worm) serotonin transporter b 0.2426 0.534 1
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0022 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0017 0.0085
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.018 0.0172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4286 0.9466 0.9466
Brugia malayi RNase H family protein 0.0026 0.0013 0.001
Schistosoma mansoni hypothetical protein 0.0096 0.017 0.0162
Schistosoma mansoni growth hormone secretagogue receptor 0.0101 0.018 0.0172
Echinococcus granulosus neuropeptide receptor 0.0101 0.018 0.0172
Echinococcus granulosus sex peptide receptor 0.0101 0.018 0.0172
Schistosoma mansoni sodium-dependent amino acid transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.1626
Loa Loa (eye worm) hypothetical protein 0.1155 0.2519 0.4715
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.1155 0.2519 0.2513
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0035 0.0758
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.018 0.0172
Plasmodium vivax importin-beta 2, putative 0.0034 0.0032 0.0334
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.018 0.0172
Schistosoma mansoni phosphoglucomutase 0.0026 0.0013 0.0005
Brugia malayi beta-lactamase family protein 0.0035 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Onchocerca volvulus 0.0035 0.0035 0.004
Entamoeba histolytica hypothetical protein 0.0036 0.0036 1
Brugia malayi G protein-coupled receptor 0.0101 0.018 0.0322
Echinococcus multilocularis sodium:myo inositol cotransporter 0.4527 1 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0035 0.037
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0014 0.0006
Echinococcus multilocularis G-protein coupled receptor, putative 0.0101 0.018 0.0172
Mycobacterium ulcerans hypothetical protein 0.0028 0.0018 0.1394
Schistosoma mansoni sodium/chloride dependent transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0268 0.0497
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.1626
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0022 0.0014
Echinococcus granulosus orexin receptor type 2 0.0101 0.018 0.0172
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.1155 0.2519 0.2513
Brugia malayi AKH receptor 0.0101 0.018 0.0322
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Schistosoma mansoni hypothetical protein 0.0362 0.0759 0.0752
Echinococcus granulosus G protein coupled receptor 139 0.0101 0.018 0.0172
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.018 0.0332
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0026 0.0014 0.0006
Onchocerca volvulus 0.0101 0.018 0.0312
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Entamoeba histolytica hypothetical protein 0.0036 0.0036 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0412 0.087 0.0863
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0412 0.087 0.1626
Echinococcus multilocularis geminin 0.0341 0.0714 0.0706
Brugia malayi RNase H family protein 0.0026 0.0013 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0115 0.2514
Onchocerca volvulus Huntingtin homolog 0.0144 0.0276 0.0493
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0115 0.0107
Echinococcus granulosus g protein coupled receptor 0.0101 0.018 0.0172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0115 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0022 0.0036
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0101 0.018 0.0172
Echinococcus multilocularis orexin receptor type 2 0.0101 0.018 0.0172
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.1617
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.006
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0456 1
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Echinococcus multilocularis g-protein coupled receptor 0.0101 0.018 0.0172
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0035 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0412 0.087 0.1617
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0023 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0035 0.0045
Schistosoma mansoni hypothetical protein 0.0101 0.018 0.0172
Echinococcus granulosus hypothetical protein 0.0101 0.018 0.0172
Schistosoma mansoni thyroid hormone receptor 0.003 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0412 0.087 0.1626
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0412 0.087 0.0863
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0022 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0166 0.0158
Loa Loa (eye worm) hypothetical protein 0.0144 0.0276 0.0512
Echinococcus multilocularis sex peptide receptor 0.0101 0.018 0.0172
Brugia malayi larval opioid receptor 0.0101 0.018 0.0322
Echinococcus granulosus importin subunit beta 1 0.0034 0.0032 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0028 0.0018 0.001
Echinococcus granulosus 7tm_1 domain containing protein 0.0101 0.018 0.0172
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0017 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 0.0014 0.0006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.018 0.0172
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0022 0.0014
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0017 0.0085
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0101 0.018 0.0172
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0022 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.018 0.0172
Schistosoma mansoni hypothetical protein 0.0034 0.0032 0.0024
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0101 0.018 0.0332
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0022 0.0014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.3419
Brugia malayi GH02984p 0.1155 0.2519 0.471
Brugia malayi G-protein coupled receptor 0.0101 0.018 0.0322
Brugia malayi hypothetical protein 0.0144 0.0276 0.0502
Onchocerca volvulus 0.0101 0.018 0.0312
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0018 0.0398
Schistosoma mansoni opsin-like receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.006
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.2137 0.4697 0.8796
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0086 0.0078
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.018 0.0172
Onchocerca volvulus 0.0101 0.018 0.0312
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0022 0.0026
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0101 0.018 0.0172
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0022 0.0014
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0101 0.018 0.0172
Onchocerca volvulus 0.0028 0.0018 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0166 0.0158
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0035 0.2858
Onchocerca volvulus 0.2426 0.534 1
Schistosoma mansoni voltage-gated potassium channel 0.0286 0.0591 0.0583
Loa Loa (eye worm) hypothetical protein 0.0412 0.087 0.1626
Onchocerca volvulus 0.003 0.0022 0.0016
Onchocerca volvulus 0.0101 0.018 0.0312
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0022 0.0014
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) beta-lactamase 0.0035 0.0035 0.006
Schistosoma mansoni sodium/chloride dependent transporter 0.0412 0.087 0.0863
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0022 0.0014
Brugia malayi beta-lactamase family protein 0.0035 0.0035 0.005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0035 0.006
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.006
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.1617
Plasmodium falciparum amino acid transporter, putative 0.0412 0.087 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0035 0.2858
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0166 0.0158
Echinococcus granulosus g protein coupled receptor 0.0101 0.018 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0022 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0035 0.0448
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0021 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 0.0014 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0035 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0032 0.0055
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0412 0.087 0.0863
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Schistosoma mansoni neuropeptide receptor 0.0101 0.018 0.0172
Echinococcus multilocularis fmrfamide receptor 0.0101 0.018 0.0172
Trichomonas vaginalis set domain proteins, putative 0.024 0.0489 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0101 0.018 0.0172
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0268 0.0497
Brugia malayi Pre-SET motif family protein 0.003 0.0023 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0022 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0018 0.1394
Brugia malayi Pre-SET motif family protein 0.0211 0.0424 0.0781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0022 0.0036
Treponema pallidum sodium- and chloride- dependent transporter 0.2426 0.534 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0035 0.0045
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0022 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0018 0.0451
Brugia malayi steroid hormone receptor 0.003 0.0022 0.0026
Mycobacterium tuberculosis Conserved protein 0.0035 0.0035 0.0758
Brugia malayi ORL1-like opioid receptor 0.0101 0.018 0.0322
Toxoplasma gondii ABC1 family protein 0.0035 0.0035 0.0085
Echinococcus granulosus tachykinin peptides receptor 99D 0.0101 0.018 0.0172
Schistosoma mansoni opsin-like receptor 0.0101 0.018 0.0172
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0022 0.0016
Onchocerca volvulus 0.0412 0.087 0.1609
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0022 0.0014
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0101 0.018 0.0322
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0115 0.0107
Leishmania major hypothetical protein, conserved 0.0035 0.0035 0.0045
Loa Loa (eye worm) hypothetical protein 0.0412 0.087 0.1626
Brugia malayi RE15519p 0.0101 0.018 0.0322
Plasmodium falciparum importin beta, putative 0.0034 0.0032 0.0334
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0014 0.0006
Echinococcus granulosus high affinity choline transporter 1 0.1155 0.2519 0.2513
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0019
Schistosoma mansoni hypothetical protein 0.0101 0.018 0.0172
Schistosoma mansoni biogenic amine receptor 0.0101 0.018 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0022 0.0026
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0018 0.1394
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0035 0.2858
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.018 0.0172
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.018 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0035 0.0448
Schistosoma mansoni inositol transporter 0.4527 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0101 0.018 0.0172
Onchocerca volvulus 0.0035 0.0035 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.018 0.0172
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0022 0.0014
Brugia malayi sulfakinin receptor protein 0.0101 0.018 0.0322
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0036 0.0028
Brugia malayi Dopamine receptor protein 2 0.0101 0.018 0.0322
Brugia malayi hypothetical protein 0.0412 0.087 0.1617
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0115 0.0107
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis sodium and chloride dependent glycine 0.0412 0.087 0.0863
Echinococcus granulosus sodium:glucose cotransporter 2 0.4527 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0035 0.0758
Echinococcus granulosus fmrfamide receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0412 0.087 0.1626
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0023 0.0015
Echinococcus granulosus sodium:myo inositol cotransporter 0.4527 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0055 0.0077 0.0069
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.018 0.0172
Onchocerca volvulus Huntingtin homolog 0.0144 0.0276 0.0493
Loa Loa (eye worm) hypothetical protein 0.0578 0.124 0.2318
Mycobacterium tuberculosis Conserved protein 0.0035 0.0035 0.0758
Echinococcus granulosus serotonin receptor 0.0101 0.018 0.0172
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.018 0.0172
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0101 0.018 0.0172
Schistosoma mansoni hypothetical protein 0.0052 0.0073 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0086 0.0078
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0026 0.0014 0.0011
Echinococcus granulosus solute carrier family 5 0.4527 1 1
Brugia malayi Melatonin receptor type 1A 0.0101 0.018 0.0322
Schistosoma mansoni adenoreceptor 0.0101 0.018 0.0172
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0286 0.0591 0.0583
Brugia malayi putative neuropeptide receptor 0.0101 0.018 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.2426 0.534 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0286 0.0591 0.0583
Brugia malayi Sodium:solute symporter family protein 0.1155 0.2519 0.471
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0036 0.0028
Brugia malayi RNA, U transporter 1 0.0096 0.017 0.0304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0166 0.0158
Brugia malayi hypothetical protein 0.0036 0.0036 0.0053
Echinococcus multilocularis transfer RNA-Gly 0.0026 0.0014 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.4286 0.9466 0.9466
Loa Loa (eye worm) hypothetical protein 0.1155 0.2519 0.4715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0022 0.0036
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0286 0.0591 0.1093
Brugia malayi Dopamine receptor protein 1 0.0101 0.018 0.0322
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0018 0.1394
Echinococcus granulosus g-protein coupled receptor 0.0101 0.018 0.0172
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0022 0.0014
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0022 0.0014
Schistosoma mansoni hypothetical protein 0.0101 0.018 0.0172
Echinococcus multilocularis shaker cognate 0.0026 0.0014 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0022 0.0026
Trypanosoma brucei unspecified product 0.0028 0.0018 0.001
Brugia malayi G protein-coupled receptor F59B2.13 0.0101 0.018 0.0322
Schistosoma mansoni opsin-like receptor 0.0101 0.018 0.0172
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0055 0.0077 0.0069
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0034 0.0032 0.0054
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0101 0.018 0.0322
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0014 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0035 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0026 0.0014 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.018 0.0332
Brugia malayi Sodium:neurotransmitter symporter family protein 0.2426 0.534 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0115 0.0217
Echinococcus multilocularis solute carrier family 5 0.4527 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0014 0.0006
Entamoeba histolytica hypothetical protein 0.0036 0.0036 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0018 0.1394
Echinococcus multilocularis somatostatin receptor 0.0101 0.018 0.0172
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0035 0.0758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0022 0.0036
Onchocerca volvulus 0.0101 0.018 0.0312
Schistosoma mansoni nuclear hormone receptor 0.003 0.0022 0.0014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0047 0.0715
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0035 0.0026
Brugia malayi GnHR receptor homolog 0.0101 0.018 0.0322
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.018 0.0172
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0101 0.018 0.0172
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0014 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0274 0.0563 0.0556
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.3419
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0014 0.0006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) hypothetical protein 0.2426 0.534 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0101 0.018 0.0332
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0101 0.018 0.0322
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0014 0.0006
Entamoeba histolytica hypothetical protein 0.0036 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.0591 0.1102
Onchocerca volvulus 0.024 0.0489 0.0893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Onchocerca volvulus 0.0035 0.0035 0.004
Schistosoma mansoni neuropeptide f receptor 76f 0.0101 0.018 0.0172
Mycobacterium leprae Probable lipase LipE 0.0035 0.0035 1
Plasmodium vivax hypothetical protein, conserved 0.0412 0.087 1
Brugia malayi MH2 domain containing protein 0.014 0.0268 0.0487
Brugia malayi small heat shock protein 0.0578 0.124 0.231
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0412 0.087 0.0863
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0115 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.018 0.0172
Echinococcus multilocularis snurportin 1 0.0362 0.0759 0.0752
Brugia malayi ecdysteroid receptor 0.003 0.0022 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Trypanosoma brucei C-8 sterol isomerase, putative 0.2137 0.4697 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0067 0.011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.1155 0.2519 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0166 0.0158
Schistosoma mansoni neuropeptide receptor 0.0101 0.018 0.0172
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0115 0.0405
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0101 0.018 0.0332
Schistosoma mansoni amine GPCR 0.0101 0.018 0.0172
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0412 0.087 1
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Trichomonas vaginalis esterase, putative 0.0035 0.0035 0.0448
Onchocerca volvulus 0.0101 0.018 0.0312
Onchocerca volvulus 0.0101 0.018 0.0312
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0022 0.0014
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0018 0.001
Schistosoma mansoni vesicular amine transporter 0.0026 0.0014 0.0006
Schistosoma mansoni hypothetical protein 0.0341 0.0714 0.0706
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0166 0.0158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0067 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0022 0.0026
Schistosoma mansoni amine GPCR 0.0101 0.018 0.0172
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.018 0.0172
Brugia malayi putative neuropeptide receptor NPR1 0.0101 0.018 0.0322
Schistosoma mansoni coup transcription factor 0.003 0.0022 0.0014
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0412 0.087 0.0863
Toxoplasma gondii hypothetical protein 0.0412 0.087 0.3419
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0035 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0022 0.0026
Schistosoma mansoni myosin xvIII 0.0101 0.018 0.0172
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0023 0.0041
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.018 0.0172
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0023 0.0015
Echinococcus granulosus ribonuclease H1 0.0026 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni neuropeptide receptor 0.0101 0.018 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0022 0.0026
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0101 0.018 0.0172
Echinococcus multilocularis neuropeptide receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0032 0.0039
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.1617
Brugia malayi G-protein coupled receptor 0.0101 0.018 0.0322
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0055 0.0077 0.013
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus granulosus alpha 1A adrenergic receptor 0.0101 0.018 0.0172
Onchocerca volvulus 0.0101 0.018 0.0312
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2426 0.534 0.5336
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0018 0.0451
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0032 0.0045
Brugia malayi beta-lactamase 0.0035 0.0035 0.005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) hypothetical protein 0.0412 0.087 0.1626
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.006
Echinococcus multilocularis fmrfamide receptor 0.0101 0.018 0.0172
Brugia malayi neuropeptide F receptor 0.0101 0.018 0.0322
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0022 0.0014
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0101 0.018 0.0172
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0022 0.0036
Echinococcus granulosus serotonin transporter 0.2426 0.534 0.5336
Leishmania major C-8 sterol isomerase-like protein 0.2137 0.4697 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0017 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0018 0.0451
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0026 0.0014 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.018 0.0172
Leishmania major importin beta-1 subunit, putative 0.0027 0.0017 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0022 0.0026
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0412 0.087 0.0863
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0018 0.001
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0412 0.087 0.0863
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0029
Schistosoma mansoni histamine h1 receptor 0.0101 0.018 0.0172
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0036
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0166 0.0307
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0035 0.0758
Brugia malayi Tachykinin-like peptides receptor 99D 0.0101 0.018 0.0322
Echinococcus multilocularis serotonin receptor 0.0101 0.018 0.0172
Echinococcus multilocularis neuropeptide receptor A26 0.0101 0.018 0.0172
Loa Loa (eye worm) voltage-gated potassium channel 0.0026 0.0014 0.0021
Echinococcus granulosus geminin 0.0341 0.0714 0.0706
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.018 0.0172
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0022 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0022 0.0014
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2137 0.4697 0.8795
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0101 0.018 0.0172
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0018 0.1394
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0022 0.0016
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0055 0.0077 0.014
Schistosoma mansoni sodium/solute symporter 0.1155 0.2519 0.2513
Brugia malayi RNase H family protein 0.0026 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0022 0.0026
Schistosoma mansoni biogenic amine receptor 0.0101 0.018 0.0172
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0412 0.087 0.3419
Brugia malayi nuclear receptor NHR-88 0.003 0.0022 0.0026
Loa Loa (eye worm) solute carrier family 6 member 4 0.2426 0.534 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0035 0.0448
Onchocerca volvulus Neuropeptide F receptor homolog 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0412 0.087 0.1626
Echinococcus multilocularis serotonin receptor 0.0101 0.018 0.0172
Mycobacterium tuberculosis Conserved protein 0.0035 0.0035 0.0758
Schistosoma mansoni amine GPCR 0.0101 0.018 0.0172
Echinococcus granulosus neuropeptide s receptor 0.0101 0.018 0.0172
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0036 0.0028
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Giardia lamblia Ribonuclease H 0.0026 0.0013 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0035 0.0026
Loa Loa (eye worm) TYRA-2 protein 0.0101 0.018 0.0332
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0022 0.0026
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0067 0.011
Echinococcus granulosus allatostatin A receptor 0.0101 0.018 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0035 0.0045
Schistosoma mansoni high-affinity choline transporter 0.1155 0.2519 0.2513
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0424 0.0791
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.018 0.0172
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0003 0.0055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0022 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0101 0.018 0.0172
Toxoplasma gondii hypothetical protein 0.0412 0.087 0.3419
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0023 0.0015
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0101 0.018 0.0332
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.018 0.0172
Mycobacterium ulcerans hypothetical protein 0.0035 0.0035 0.2858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0047 0.0715
Loa Loa (eye worm) melatonin receptor type 1A 0.0101 0.018 0.0332
Schistosoma mansoni biogenic amine receptor 0.0101 0.018 0.0172
Brugia malayi Serotonin receptor 0.0101 0.018 0.0322
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0022 0.0014
Echinococcus granulosus shaker cognate 0.0026 0.0014 0.0006
Echinococcus granulosus snurportin 1 0.0362 0.0759 0.0752
Echinococcus granulosus potassium voltage gated channel protein 0.0026 0.0014 0.0006
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0026 0.0013 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0022 0.0026
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.018 0.0172
Onchocerca volvulus 0.003 0.0023 0.0019
Echinococcus granulosus sodium and chloride dependent glycine 0.0412 0.087 0.0863
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0035 0.0758
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0101 0.018 0.0172
Echinococcus multilocularis dro:myosuppressin receptor 0.0101 0.018 0.0172
Echinococcus granulosus somatostatin receptor 0.0101 0.018 0.0172
Plasmodium falciparum transporter, putative 0.0412 0.087 1
Echinococcus granulosus dro:myosuppressin receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.2426 0.534 1
Echinococcus multilocularis high affinity choline transporter 1 0.1155 0.2519 0.2513
Onchocerca volvulus 0.0412 0.087 0.1609
Loa Loa (eye worm) hypothetical protein 0.052 0.1111 0.2077
Echinococcus multilocularis g protein coupled receptor 0.0101 0.018 0.0172
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0412 0.087 0.0863
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 0.0014 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.018 0.0172
Echinococcus granulosus 7TM GPCR rhodopsin 0.0101 0.018 0.0172
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0412 0.087 0.0863
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Echinococcus multilocularis neuropeptide s receptor 0.0101 0.018 0.0172
Schistosoma mansoni importin beta-1 0.0034 0.0032 0.0023
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0022 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0022 0.0026
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni inositol transporter 0.4527 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.006
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0026 0.0014 0.0006
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0101 0.018 0.0172
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0101 0.018 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0166 0.0158
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.018 0.0172
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0022 0.0014
Onchocerca volvulus 0.0412 0.087 0.1609
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0018 0.001
Echinococcus granulosus potassium voltage gated channel protein 0.0026 0.0014 0.0006
Brugia malayi neuropeptide F receptor 0.0101 0.018 0.0322
Echinococcus granulosus neuropeptide receptor 0.0101 0.018 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0035 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.018 0.0172
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 0.0014 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.018 0.0172
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0101 0.018 0.0172
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0101 0.018 0.0172
Echinococcus multilocularis sodium and chloride dependent glycine 0.0412 0.087 0.0863
Plasmodium vivax SET domain protein, putative 0.003 0.0023 0.0241
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0166 0.0296
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0035 0.0448
Echinococcus granulosus g protein coupled receptor 0.0101 0.018 0.0172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0022 0.0014
Schistosoma mansoni sodium/chloride dependent transporter 0.2426 0.534 0.5336
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2137 0.4697 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0023 0.0015
Brugia malayi nuclear hormone receptor 0.003 0.0022 0.0026
Schistosoma mansoni alpha-1 adrenergic receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0115 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0101 0.018 0.0172
Schistosoma mansoni thyroid hormone receptor 0.003 0.0022 0.0014
Echinococcus multilocularis sodium:glucose cotransporter 2 0.4527 1 1
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0022 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0022 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Brugia malayi Serotonin receptor 0.0101 0.018 0.0322
Schistosoma mansoni amine GPCR 0.0101 0.018 0.0172
Schistosoma mansoni neuropeptide receptor 0.0101 0.018 0.0172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0022 0.0014
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0101 0.018 0.0322
Mycobacterium ulcerans lipase LipD 0.0035 0.0035 0.2858
Loa Loa (eye worm) hypothetical protein 0.005 0.0067 0.0121
Loa Loa (eye worm) norepinephrine transporter 0.2426 0.534 1
Onchocerca volvulus 0.1155 0.2519 0.4705
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Echinococcus multilocularis ribonuclease H1 0.0026 0.0013 0.0005
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.018 0.0172
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0412 0.087 0.0863
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Brugia malayi Dopamine receptor 0.0101 0.018 0.0322
Schistosoma mansoni hypothetical protein 0.0341 0.0714 0.0706
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0029
Echinococcus multilocularis g protein coupled receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0775 0.1676 0.3136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0018 0.0398
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0101 0.018 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0115 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.018 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.018 0.0172
Onchocerca volvulus 0.0101 0.018 0.0312
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 0.0014 0.0006
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0032 0.0073
Echinococcus granulosus potassium voltage gated channel protein 0.0286 0.0591 0.0583
Echinococcus multilocularis g protein coupled receptor 0.0101 0.018 0.0172
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0023 0.0015
Brugia malayi hypothetical protein 0.0101 0.018 0.0322
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Onchocerca volvulus 0.0101 0.018 0.0312
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.018 0.0172
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.0144 0.0276 0.0512
Echinococcus multilocularis serotonin transporter 0.2426 0.534 0.5336
Echinococcus multilocularis neuropeptide FF receptor 2 0.0101 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0101 0.018 0.0332
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0035 0.0758

Activities

Activity type Activity value Assay description Source Reference
Acquisition time (functional) = 9.5 s Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 1.25 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 9.9 s Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 20 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 10.8 s Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.08 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 11.1 s Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 5 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 11.1 s Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 13.4 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.02 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 14.5 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 1.25 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 14.5 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 1.25 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 23.3 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 0.31 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 23.3 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 0.31 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 24 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.08 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 24 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.08 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 42.7 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg ChEMBL. 8355252
Acquisition time (functional) = 42.7 s Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg ChEMBL. 8355252
Cr (functional) = 3.32 mg dl-1 Serum cretinine concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 5.43+/-0.11) ChEMBL. 1501234
Cr (functional) = 3.79 mg dl-1 Serum cretinine concentration measured after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 4.64+/-0.24) ChEMBL. 1501234
Inhibition (functional) = 18 % Percent inhibition of serum creatinine by the compound given as ratio of Cr value in treated to vehicle treated ones after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 4.64+/-0.24) ChEMBL. 1501234
Inhibition (functional) = 19 % Percent inhibition of Urea nitrogen by the compound given as ratio of UN value in treated to vehicle treated ones after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 182.5+/-3.4) ChEMBL. 1501234
Inhibition (functional) = 31 % Percent inhibition of serum creatinine by the compound given as ratio of Cr value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 5.43+/-0.11) ChEMBL. 1501234
Inhibition (functional) = 37 % Percent inhibition of Urea nitrogen by the compound given as ratio of UN value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 182.5+/-3.4) ChEMBL. 1501234
Ki (binding) = 0.75 nM Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand ChEMBL. 8355252
Ki (binding) = 0.75 nM Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand ChEMBL. 8355252
Ki (binding) = 3.5 nM Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]-cyclohexyladenosine as radioligand ChEMBL. 1501234
Ki (binding) = 3.5 nM Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement. ChEMBL. 8355252
Ki (binding) = 3.5 nM Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]-cyclohexyladenosine as radioligand ChEMBL. 1501234
Ki (binding) = 3.5 nM Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement. ChEMBL. 8355252
Ki (binding) = 5.6 nM Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]-cyclohexyladenosine as radioligand ChEMBL. 1501234
Ki (binding) = 5.6 nM Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]-cyclohexyladenosine as radioligand ChEMBL. 1501234
Ki (binding) = 330 nM Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine ChEMBL. 1501234
Ki (binding) = 330 nM Binding affinity at Adenosine A2 receptor from rat striatal membranes by N-[3H] ethyladenosin-5'- uronamide displacement. ChEMBL. 8355252
Ki (binding) = 330 nM Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine ChEMBL. 1501234
Ki (binding) = 330 nM Binding affinity at Adenosine A2 receptor from rat striatal membranes by N-[3H] ethyladenosin-5'- uronamide displacement. ChEMBL. 8355252
Ki (binding) = 560 nM Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine ChEMBL. 1501234
Ki (binding) = 560 nM Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine ChEMBL. 1501234
Ki ratio (binding) = 94 Ratio of Ki at A2 receptor to that of A1 receptor ChEMBL. 1501234
Ki ratio (binding) = 100 Ratio of Ki at A2 receptor to that of A1 receptor ChEMBL. 1501234
Na (functional) = 0.176 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 0.1 mg/kg to rats(potassium and sodium excretion in control rat is 0.189+/-0.005) ChEMBL. 1501234
Na (functional) = 0.298 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 25 mg/kg to rats(potassium and sodium excretion in control rat is 0.143+/-0.019) ChEMBL. 1501234
Na (functional) = 0.307 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 1.6 mg/kg to rats(potassium and sodium excretion in control rat is 0.105+/-0.002) ChEMBL. 1501234
Na (functional) = 0.358 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 0.4 mg/kg to rats(potassium and sodium excretion in control rat is 0.134+/-0.0047) ChEMBL. 1501234
Na (functional) = 0.429 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 6.25 mg/kg to rats(potassium and sodium excretion in control rat is 0.195+/-0.015) ChEMBL. 1501234
Na (functional) = 0.448 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 1.6 mg/kg to rats(potassium and sodium excretion in control rat is 0.252+/-0.022) ChEMBL. 1501234
Na (functional) = 0.487 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 6.25 mg/kg to rats(potassium and sodium excretion in control rat is 0.138+/-0.008) ChEMBL. 1501234
Na+/K+ (functional) = 0.92 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.1 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.16 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.55 Ratio of sodium ion/potassium ion concentration in urine of rats following 6.25 mg/kg p.o. ChEMBL. 1501234
Na+/K+ (functional) = 1.58 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.88 Ratio of sodium ion/potassium ion concentration in urine of rats following 6.25 mg/kg p.o. ChEMBL. 1501234
Na+/K+ (functional) = 2.1 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 2.16 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
Ratio (binding) = 94 Ratio of Ki for A2 and A1 adenosine receptors ChEMBL. 8355252
Ratio (binding) = 440 Ratio of Ki against rat forebrain membrane A1 and rat striatal membrane A2 adenosine receptors ChEMBL. 8355252
Retention time (functional) = 18 s Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 1.25 mg/kg ChEMBL. 8355252
Retention time (functional) = 18.5 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.02 mg/kg ChEMBL. 8355252
Retention time (functional) = 22.6 s Retention time in Scopolamine induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg ChEMBL. 8355252
Retention time (functional) = 29.6 s Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg ChEMBL. 8355252
Retention time (functional) = 30.7 s Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.08 mg/kg ChEMBL. 8355252
Retention time (functional) = 35.1 s Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 20 mg/kg ChEMBL. 8355252
Retention time (functional) = 83.2 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.08 mg/kg ChEMBL. 8355252
Retention time (functional) = 83.2 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.08 mg/kg ChEMBL. 8355252
Retention time (functional) = 139.7 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.31 mg/kg ChEMBL. 8355252
Retention time (functional) = 139.7 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.31 mg/kg ChEMBL. 8355252
Retention time (functional) = 317.3 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 1.25 mg/kg ChEMBL. 8355252
Retention time (functional) = 317.3 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 1.25 mg/kg ChEMBL. 8355252
Retention time (functional) = 384.1 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg ChEMBL. 8355252
Retention time (functional) = 384.1 s Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg ChEMBL. 8355252
T/C (functional) = 0.91 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.1 mg/Kg ChEMBL. 1501234
T/C (functional) = 0.94 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.1 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.78 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.88 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.09 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.1 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.2 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.4 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.67 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.81 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.93 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
T/C (functional) = 3.52 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg ChEMBL. 1501234
T/C (functional) = 4.3 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg ChEMBL. 1501234
UN (functional) = 115.4 mg dl-1 Urea nitrogen concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 182.5+/-3.4) ChEMBL. 1501234
UN (functional) = 147 mg dl-1 Urea nitrogen concentration measured after intraperitoneal administration of 10 mg/kg of compound to rats(vehicle 182.5+/-3.4) ChEMBL. 1501234
Urine volume (functional) = 0.86 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 0.1 mg/kg to rats(control volume is 0.95+/-0.03) ChEMBL. 1501234
Urine volume (functional) = 1.8 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 25 mg/kg to rats(control volume is 0.96+/-0.06) ChEMBL. 1501234
Urine volume (functional) = 2.22 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 1.6 mg/kg to rats(control volume is 0.79+/-0.12) ChEMBL. 1501234
Urine volume (functional) = 2.25 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 0.4 mg/kg to rats(control volume is 0.80+/-0.04) ChEMBL. 1501234
Urine volume (functional) = 2.52 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 1.6 mg/kg to rats(control volume is 1.20+/-0.14) ChEMBL. 1501234
Urine volume (functional) = 2.64 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 6.25 mg/kg to rats(control volume is 1.10+/-0.09) ChEMBL. 1501234
Urine volume (functional) = 2.84 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 6.25 mg/kg to rats(control volume is 0.66+/-0.04) ChEMBL. 1501234

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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