Detailed information for compound 135643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 979.781 | Formula: C34H48N9O17P3S--
  • H donors: 9 H acceptors: 15 LogP: -3.94 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(NCCSC(C(=O)NCCc1c[nH]c2c1cccc2)C)CCNC(=O)C(C(COP(=O)(OP(=O)(OCC1OC(C(C1OP(=O)([O-])[O-])O)n1cnc2c1ncnc2N)O)O)(C)C)O
  • InChi: 1S/C34H50N9O17P3S/c1-19(31(47)37-10-8-20-14-39-22-7-5-4-6-21(20)22)64-13-12-36-24(44)9-11-38-32(48)28(46)34(2,3)16-57-63(54,55)60-62(52,53)56-15-23-27(59-61(49,50)51)26(45)33(58-23)43-18-42-25-29(35)40-17-41-30(25)43/h4-7,14,17-19,23,26-28,33,39,45-46H,8-13,15-16H2,1-3H3,(H,36,44)(H,37,47)(H,38,48)(H,52,53)(H,54,55)(H2,35,40,41)(H2,49,50,51)/p-2
  • InChiKey: FDMGWGASOWLEIB-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.043 0.0518
Brugia malayi Pre-SET motif family protein 0.0238 0.1809 0.2177
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0153 0.0184
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0393 0.0473
Echinococcus multilocularis cathepsin L 0.0102 0.0682 0.0821
Leishmania major cysteine peptidase A (CPA) 0.0276 0.2119 0.7062
Loa Loa (eye worm) glutathione reductase 0.0037 0.0149 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1444 0.1738
Trypanosoma cruzi ISWI complex protein 0.0033 0.0112 0.0134
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Onchocerca volvulus 0.0192 0.1429 0.3484
Trichomonas vaginalis penicillin-binding protein, putative 0.0192 0.1429 0.4743
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0073 0.0439 0.0529
Toxoplasma gondii preprocathepsin c precursor, putative 0.0095 0.0623 0.1304
Brugia malayi hypothetical protein 0.009 0.0581 0.0699
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.0589 0.1375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0085 0.0542 0.0652
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0016 0.0077
Loa Loa (eye worm) RNA binding protein 0.0067 0.0393 0.0473
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Brugia malayi beta-lactamase family protein 0.0192 0.1429 0.1719
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Brugia malayi cathepsin L-like precursor 0.0268 0.206 0.2478
Schistosoma mansoni zinc finger protein 0.0033 0.0112 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0439 0.1434
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0149 0.0179
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0073 0.0439 0.1464
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0218 0.1642 0.1975
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0143 0.0172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0192 0.1429 0.1719
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0439 0.1434
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Echinococcus granulosus chromobox protein 1 0.015 0.1084 0.1304
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0439 0.1464
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Schistosoma mansoni jumonji domain containing protein 0.0158 0.1142 0.1374
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0625 0.0484
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi cathepsin B-like cysteine proteinase 0.1024 0.8311 1
Loa Loa (eye worm) hypothetical protein 0.0276 0.2119 0.255
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0276 0.2119 1
Trypanosoma cruzi cysteine peptidase, putative 0.0102 0.0682 0.0821
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0042 0.0105
Entamoeba histolytica cysteine proteinase 2 0.0102 0.0682 0.3186
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0095 0.0623 0.2939
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.011 0.0132
Echinococcus multilocularis geminin 0.069 0.5552 0.668
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Onchocerca volvulus 0.0192 0.1429 0.3484
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0149
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0042 0.0051
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0268 0.206 0.2478
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0311 0.2415 0.2905
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Echinococcus granulosus transcription factor Dp 1 0.0126 0.0882 0.1061
Loa Loa (eye worm) fibroinase 0.0276 0.2119 0.255
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0218 0.1642 0.1975
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Loa Loa (eye worm) cysteine protease 0.0276 0.2119 0.255
Echinococcus granulosus beta LACTamase domain containing family member 0.0192 0.1429 0.1719
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0459 0.0552
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Toxoplasma gondii cathepsin B 0.0382 0.3001 0.6283
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0623 0.2939
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1024 0.8311 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0623 0.1285
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.6579 0.7915
Entamoeba histolytica cysteine proteinase, putative 0.0276 0.2119 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.043 0.0518
Leishmania major hypothetical protein, conserved 0.0192 0.1429 0.4761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Schistosoma mansoni hypothetical protein 0.0302 0.2338 0.2813
Schistosoma mansoni cpg binding protein 0.0034 0.0121 0.0146
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni importin beta-1 0.0028 0.0072 0.0087
Echinococcus granulosus glutamate receptor 1 0.0042 0.0188 0.0226
Schistosoma mansoni hypothetical protein 0.0025 0.0042 0.0051
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Onchocerca volvulus Cathepsin F homolog 0.0276 0.2119 0.5218
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0339 0.0408
Plasmodium falciparum serine repeat antigen 8 0.0095 0.0623 0.2939
Mycobacterium tuberculosis Probable reductase 0.0086 0.0546 0.0404
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0255 0.0306
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0042 0.0088
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Leishmania major hypothetical protein, conserved 0.0033 0.0112 0.0372
Leishmania major hypothetical protein, conserved 0.0073 0.0439 0.1464
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0095 0.0623 0.0749
Mycobacterium tuberculosis Probable hydrolase 0.0192 0.1429 0.1299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Onchocerca volvulus 0.0162 0.1177 0.2851
Onchocerca volvulus 0.0066 0.0386 0.0863
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0108 0.0129
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Mycobacterium ulcerans beta-lactamase 0.0192 0.1429 1
Brugia malayi AF-10 protein 0.002 0.0002 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0271 0.2081 0.6924
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0073 0.0439 0.0529
Onchocerca volvulus 0.0085 0.0542 0.1255
Echinococcus multilocularis chromobox protein 2 0.0025 0.0042 0.0051
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Plasmodium vivax vivapain-1 0.0102 0.0682 0.322
Leishmania major GTP-binding protein, putative 0.0021 0.0011 0.0035
Trichomonas vaginalis esterase, putative 0.0192 0.1429 0.4743
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1434
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Plasmodium vivax vivapain-2 0.0276 0.2119 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Schistosoma mansoni chromobox protein 0.0025 0.0042 0.0051
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0095 0.0623 0.2939
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0042 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0072 0.0241
Giardia lamblia Hypothetical protein 0.0073 0.0439 0.09
Giardia lamblia Encystation-specific protease 0.0095 0.0623 0.1285
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0439 0.0529
Brugia malayi hypothetical protein 0.0025 0.0042 0.0051
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0045 0.0151
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0198 0.1479 0.178
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0046 0.0055
Plasmodium falciparum importin beta, putative 0.0028 0.0072 0.0342
Echinococcus granulosus lamin 0.0085 0.0542 0.0652
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0048 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0143 0.0172
Entamoeba histolytica cysteine proteinase, putative 0.0276 0.2119 1
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.1873 0.2254
Giardia lamblia Cathepsin L-like protease 0.0095 0.0623 0.1285
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0108 0.0129
Loa Loa (eye worm) hypothetical protein 0.0083 0.0524 0.0631
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0072 0.0152
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0028 0.0034
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.009 0.0581 0.0699
Brugia malayi SET domain containing protein 0.0026 0.0058 0.0069
Brugia malayi CXXC zinc finger family protein 0.0028 0.0074 0.0089
Onchocerca volvulus 0.0095 0.0623 0.1459
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0207 0.0249
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0218 0.1642 0.1975
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0492 0.0592
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0095 0.0623 0.0749
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0073 0.0439 0.0529
Schistosoma mansoni lamin 0.0085 0.0542 0.0652
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0178 0.0214
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Giardia lamblia Cathepsin B precursor 0.0382 0.3001 0.6274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1429 0.4743
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0046 0.0055
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.1444 0.1738
Schistosoma mansoni cpg binding protein 0.0028 0.0074 0.0089
Brugia malayi Protein cec-1. 0.0025 0.0042 0.0051
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Echinococcus granulosus PHD finger protein rhinoceros 0.0061 0.0339 0.0408
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni lamin 0.0085 0.0542 0.0652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0028 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0276 0.2119 0.255
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0095 0.0623 0.2939
Brugia malayi hypothetical protein 0.0162 0.1177 0.1416
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0192 0.1429 0.1719
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Onchocerca volvulus Cathepsin L homolog 0.0276 0.2119 0.5218
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0042 0.0105
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0623 0.1285
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0102 0.0682 0.0821
Echinococcus granulosus Chromobox protein 3 0.0025 0.0042 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1444 0.1738
Onchocerca volvulus 0.0505 0.4022 1
Schistosoma mansoni intermediate filament proteins 0.0085 0.0542 0.0652
Schistosoma mansoni chromobox protein 0.015 0.1084 0.1304
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0393 0.0473
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0073 0.0439 0.0529
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0073 0.0439 0.2073
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Giardia lamblia Cathepsin B precursor 0.0382 0.3001 0.6274
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0143 0.0172
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0276 0.2119 0.255
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0192 0.1429 0.1719
Giardia lamblia PHD finger protein 15 0.0061 0.0339 0.069
Trypanosoma cruzi cruzipain precursor, putative 0.0276 0.2119 0.255
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0689 0.0829
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Loa Loa (eye worm) hypothetical protein 0.0039 0.0165 0.0198
Onchocerca volvulus 0.0059 0.0329 0.0721
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0102 0.0682 0.0821
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0042 0.0199
Mycobacterium leprae Probable lipase LipE 0.0192 0.1429 1
Echinococcus multilocularis musashi 0.0085 0.0542 0.0652
Echinococcus granulosus cysteine protease 0.0102 0.0682 0.0821
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Loa Loa (eye worm) CHromoDomain protein family member 0.003 0.009 0.0108
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.0682 0.2246
Onchocerca volvulus 0.0192 0.1429 0.3484
Loa Loa (eye worm) hypothetical protein 0.0066 0.0386 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0623 0.2048
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Brugia malayi Muscleblind-like protein 0.0311 0.2415 0.2905
Schistosoma mansoni hypothetical protein 0.007 0.042 0.0505
Onchocerca volvulus 0.0276 0.2119 0.5218
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0042 0.0088
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126
Mycobacterium tuberculosis Conserved protein 0.0192 0.1429 0.1299
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0046 0.0055
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0042 0.0051
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0095 0.0623 0.2939
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0042 0.0088
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Plasmodium falciparum cysteine proteinase falcipain 1 0.0102 0.0682 0.322
Plasmodium vivax SET domain protein, putative 0.0035 0.0125 0.0592
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis chromobox protein 1 0.015 0.1084 0.1304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Brugia malayi fibroinase precursor 0.0095 0.0623 0.0749
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0119 0.0143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1024 0.8311 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0072 0.0434 0.0522
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0073 0.0439 0.0529
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0108 0.0129
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0623 0.2939
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0095 0.0623 0.2939
Entamoeba histolytica hypothetical protein 0.0095 0.0623 0.2904
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0149
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.0919 0.1106
Plasmodium falciparum serine repeat antigen 7 0.0095 0.0623 0.2939
Loa Loa (eye worm) runx1 0.0063 0.0363 0.0437
Echinococcus granulosus cathepsin l1 0.0268 0.206 0.2478
Echinococcus multilocularis zinc finger protein 0.0044 0.0202 0.0243
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0524 0.4175 0.5024
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0095 0.0623 0.2904
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0095 0.0623 0.0749
Echinococcus multilocularis snurportin 1 0.0302 0.2338 0.2813
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0073 0.0439 0.0529
Brugia malayi Papain family cysteine protease containing protein 0.0276 0.2119 0.255
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0042 0.0199
Mycobacterium tuberculosis Probable esterase LipL 0.0192 0.1429 0.1299
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Plasmodium vivax glutathione reductase, putative 0.0037 0.0149 0.0701
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.003 0.009 0.0108
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0035
Brugia malayi Cathepsin L-like precursor 0.0268 0.206 0.2478
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Echinococcus multilocularis glutamate receptor 4 0.0042 0.0188 0.0226
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0623 0.2939
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0073 0.0439 0.0529
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.042 0.0505
Echinococcus granulosus cpg binding protein 0.0034 0.0121 0.0146
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1444 0.1738
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0125 0.0263
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0085 0.0102
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Plasmodium falciparum serine repeat antigen 1 0.0095 0.0623 0.2939
Schistosoma mansoni hypothetical protein 0.069 0.5552 0.668
Echinococcus multilocularis cpg binding protein 0.0034 0.0121 0.0146
Onchocerca volvulus 0.0276 0.2119 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Schistosoma mansoni cpg binding protein 0.0034 0.0121 0.0146
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0623 0.0749
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0492 0.0592
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0095 0.0623 0.2048
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0198 0.1479 0.178
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0125 0.0151
Schistosoma mansoni cathepsin F (C01 family) 0.0276 0.2119 0.255
Brugia malayi Bromodomain containing protein 0.0066 0.0382 0.0459
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.043 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.0682 0.2246
Brugia malayi hypothetical protein 0.0075 0.0459 0.0552
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0546 0.0404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1444 0.1738
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0218 0.1642 0.7736
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Loa Loa (eye worm) hypothetical protein 0.0268 0.206 0.2478
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Brugia malayi CHD4 protein 0.003 0.009 0.0108
Echinococcus multilocularis GPCR, family 2 0.0033 0.0108 0.0129
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0542 0.0652
Plasmodium vivax vivapain-3 0.0102 0.0682 0.322
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0382 0.3001 0.361
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0835 0.1004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni ran 0.0021 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.014 0.0996 0.1198
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0085 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0046 0.0055
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Echinococcus multilocularis Protein lozenge 0.0063 0.0363 0.0437
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0589 0.1935
Loa Loa (eye worm) beta-lactamase 0.0192 0.1429 0.1719
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Schistosoma mansoni hypothetical protein 0.069 0.5552 0.668
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Brugia malayi beta-lactamase 0.0192 0.1429 0.1719
Onchocerca volvulus Cathepsin L homolog 0.0276 0.2119 0.5218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1444 0.1738
Loa Loa (eye worm) hypothetical protein 0.0103 0.0689 0.0829
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0395 0.0475
Loa Loa (eye worm) cathepsin B 0.0382 0.3001 0.361
Loa Loa (eye worm) hypothetical protein 0.0088 0.0566 0.0682
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0102 0.0682 0.2274
Loa Loa (eye worm) hypothetical protein 0.0597 0.4776 0.5747
Loa Loa (eye worm) hypothetical protein 0.014 0.0996 0.1198
Echinococcus multilocularis cysteine protease 0.0276 0.2119 0.255
Toxoplasma gondii cathepsin CPC2 0.0095 0.0623 0.1304
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus cathepsin b 0.1024 0.8311 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0339 0.1601
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0102 0.0682 0.2274
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0255 0.0306
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0459 0.0552
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0095 0.0623 0.2939
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0095 0.0623 0.2939
Echinococcus multilocularis chromobox protein 1 0.015 0.1084 0.1304
Brugia malayi intermediate filament protein 0.0085 0.0542 0.0652
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0536 0.1242
Echinococcus multilocularis cathepsin L 0.0095 0.0623 0.0749
Plasmodium falciparum thioredoxin reductase 0.0037 0.0149 0.0701
Onchocerca volvulus Alhambra homolog 0.0061 0.0339 0.0747
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0073 0.0439 0.0529
Echinococcus granulosus snurportin 1 0.0302 0.2338 0.2813
Trypanosoma brucei hypothetical protein, conserved 0.0192 0.1429 0.4761
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Mycobacterium ulcerans esterase/lipase LipP 0.0192 0.1429 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0042 0.0199
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0085 0.0102
Loa Loa (eye worm) ctsf protein 0.0276 0.2119 0.255
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0046 0.0055
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0016 0.0077
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0048 0.0057
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0546 0.0404
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0095 0.0623 0.1285
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0149 0.0701
Entamoeba histolytica cysteine protease, putative 0.0276 0.2119 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0085 0.0102
Loa Loa (eye worm) hypothetical protein 0.0505 0.4022 0.484
Brugia malayi PHD-finger family protein 0.0061 0.0339 0.0408
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0095 0.0623 0.2939
Brugia malayi hypothetical protein 0.0505 0.4022 0.484
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0028 0.0059
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0042 0.0051
Brugia malayi Bromodomain containing protein 0.0164 0.1192 0.1435
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0393 0.0473
Schistosoma mansoni chromobox protein 0.0025 0.0042 0.0051
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0623 0.2939
Brugia malayi beta-lactamase family protein 0.0192 0.1429 0.1719
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0542 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0524 0.4175 0.5024
Leishmania major importin beta-1 subunit, putative 0.0023 0.0028 0.0094
Echinococcus granulosus zinc finger protein 0.0044 0.0202 0.0243
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0046 0.0055
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0051 0.0264 0.0318
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0095 0.0623 0.0749
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0042 0.0105
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0055
Mycobacterium leprae conserved hypothetical protein 0.0192 0.1429 1
Leishmania major hypothetical protein, conserved 0.0025 0.0045 0.0151
Schistosoma mansoni hypothetical protein 0.002 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0268 0.206 0.6853
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0214
Trichomonas vaginalis chromobox protein, putative 0.015 0.1084 0.3588
Schistosoma mansoni zinc finger protein 0.0044 0.0202 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0623 0.2048
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.2338 0.2813
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0546 0.0404
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Loa Loa (eye worm) hypothetical protein 0.0042 0.0188 0.0226
Echinococcus multilocularis PHD finger protein rhinoceros 0.0061 0.0339 0.0408
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0046 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0276 0.2119 0.7051
Schistosoma mansoni hypothetical protein 0.0075 0.0459 0.0552
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Onchocerca volvulus Huntingtin homolog 0.014 0.0996 0.2396
Trypanosoma cruzi major cysteine proteinase, putative 0.0095 0.0623 0.0749
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0071 0.0201
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0073 0.0439 0.0529
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Echinococcus multilocularis glutamate receptor 2 0.0072 0.0434 0.0522
Leishmania major hypothetical protein, conserved 0.0073 0.0439 0.1464
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Schistosoma mansoni cathepsin C 0.0095 0.0623 0.0749
Entamoeba histolytica cysteine proteinase 1, putative 0.0102 0.0682 0.3186
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1024 0.8311 1
Onchocerca volvulus Cathepsin L homolog 0.0095 0.0623 0.1459
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Toxoplasma gondii thioredoxin reductase 0.0037 0.0149 0.0311
Loa Loa (eye worm) hypothetical protein 0.0505 0.4022 0.484
Brugia malayi Cathepsin L-like cysteine proteinase 0.0268 0.206 0.2478
Giardia lamblia hypothetical protein 0.0073 0.0439 0.09
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0073 0.0439 0.0529
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0072 0.0087
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Echinococcus multilocularis cathepsin b 0.1024 0.8311 1
Schistosoma mansoni cathepsin S (C01 family) 0.0095 0.0623 0.0749
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0073 0.0439 0.2073
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0045 0.0214
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.0395 0.0475
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0087
Giardia lamblia Cathepsin L-like protease 0.0095 0.0623 0.1285
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0276 0.2119 0.255
Onchocerca volvulus 0.0276 0.2119 0.5218
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0192 0.1429 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0623 0.0749
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1444 0.1738
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0218 0.1642 0.1975
Loa Loa (eye worm) hypothetical protein 0.0042 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Brugia malayi jmjC domain containing protein 0.0198 0.1479 0.178
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0108 0.0129
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1024 0.8311 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0073 0.0439 0.0529
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0072 0.0434 0.0522
Trypanosoma brucei trypanothione reductase 0.0037 0.0149 0.0495
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0013
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Trypanosoma cruzi cysteine proteinase, putative 0.0102 0.0682 0.0821
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0011 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0268 0.206 0.9718
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1464
Brugia malayi Cathepsin L-like precursor 0.0268 0.206 0.2478
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0481 0.0578
Onchocerca volvulus 0.0276 0.2119 0.5218
Brugia malayi Bromodomain containing protein 0.0083 0.0523 0.0629
Echinococcus granulosus glutamate receptor subunit protein glur 0.0051 0.0264 0.0318
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0339 0.071
Schistosoma mansoni chromobox protein 0.015 0.1084 0.1304
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Echinococcus multilocularis beta LACTamase domain containing family member 0.0192 0.1429 0.1719
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0536 0.0644
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0149
Trypanosoma brucei ISWI complex protein 0.0033 0.0112 0.0372
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0042 0.0199
Brugia malayi Thioredoxin reductase 0.0037 0.0149 0.0179
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0382 0.3001 1
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0835 0.1004
Loa Loa (eye worm) hypothetical protein 0.0073 0.0439 0.0529
Echinococcus granulosus chromobox protein 2 0.0025 0.0042 0.0051
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0011 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.1809 0.2177
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0542 0.0652
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0011 0.0022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0013
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0597 0.4776 0.5747
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi hypothetical protein 0.014 0.0996 0.1198
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0218 0.1642 0.1975
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Loa Loa (eye worm) helicase 0.0025 0.0042 0.0051
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0276 0.2119 0.255
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1429 0.4743
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0625 0.0895
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0095 0.0623 0.2048
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0218 0.1642 0.5471
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0042 0.0105
Trichomonas vaginalis penicillin-binding protein, putative 0.0192 0.1429 0.4743
Brugia malayi hypothetical protein 0.0025 0.0045 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0276 0.2119 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0348 0.0419
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.043 0.0518
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0597 0.4776 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Loa Loa (eye worm) hypothetical protein 0.0061 0.0339 0.0408
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0073 0.0439 0.0529
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Onchocerca volvulus 0.0025 0.0042 0.000000029675
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0524 0.4175 0.5024
Brugia malayi cathepsin L precursor 0.0095 0.0623 0.0749
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0492 0.0592
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0042 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0072 0.0241
Mycobacterium ulcerans lipase LipD 0.0192 0.1429 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1024 0.8311 1
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1429 0.4743
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1464
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0046 0.0055
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0002 0.0004
Echinococcus granulosus cathepsin L cysteine protease 0.0102 0.0682 0.0821
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Echinococcus granulosus cathepsin b 0.1024 0.8311 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0623 0.0749
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus glutamate receptor 2 0.0072 0.0434 0.0522
Loa Loa (eye worm) hypothetical protein 0.0162 0.1177 0.1416
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0046 0.0055
Schistosoma mansoni hypothetical protein 0.0061 0.0339 0.0408
Echinococcus granulosus tar DNA binding protein 0.0067 0.0393 0.0473
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0218 0.1642 0.1975
Echinococcus multilocularis Chromo domain 0.0025 0.0042 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0623 0.2048
Echinococcus granulosus lysine specific demethylase 5A 0.0079 0.0492 0.0592
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.0395 0.0475
Onchocerca volvulus 0.0271 0.2081 0.5123
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0214
Echinococcus granulosus chromobox protein 1 0.015 0.1084 0.1304
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Onchocerca volvulus Huntingtin homolog 0.014 0.0996 0.2396
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0153 0.0184
Onchocerca volvulus 0.0276 0.2119 0.5218
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0028 0.0059
Schistosoma mansoni cathepsin F (C01 family) 0.0268 0.206 0.2478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1429 0.1719
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1429 0.1719
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Loa Loa (eye worm) hypothetical protein 0.0073 0.0439 0.0529
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0835 0.1747
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0333 0.1077
Trypanosoma cruzi major cysteine proteinase, putative 0.0095 0.0623 0.0749
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.0873 0.105
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0333 0.1077
Echinococcus granulosus cathepsin l cysteine peptidase 0.0276 0.2119 0.255
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Echinococcus granulosus peregrin 0.0066 0.0382 0.0459
Mycobacterium ulcerans hypothetical protein 0.0192 0.1429 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0382 0.3001 1
Echinococcus granulosus geminin 0.069 0.5552 0.668
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0536 0.1758
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0073 0.0439 0.1464
Echinococcus granulosus Chromo domain 0.0025 0.0042 0.0051
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.005
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0083
Echinococcus granulosus lamin dm0 0.0085 0.0542 0.0652
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Brugia malayi Importin beta-1 subunit 0.0028 0.0072 0.0087
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0085 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0689 0.0829
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Plasmodium vivax hypothetical protein, conserved 0.0192 0.1429 0.6743
Plasmodium falciparum serine repeat antigen 6 0.0095 0.0623 0.2939
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0835 0.0696
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Echinococcus granulosus GPCR family 2 0.0033 0.0108 0.0129
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Echinococcus granulosus cathepsin L 0.0095 0.0623 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0382 0.3001 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.0919 0.1106
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0192 0.1429 0.1299
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0045 0.0095
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0255 0.0306
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0071 0.0085
Schistosoma mansoni cathepsin F (C01 family) 0.0276 0.2119 0.255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0439 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Echinococcus granulosus glutamate receptor 2 0.0063 0.0357 0.043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Echinococcus multilocularis muscleblind protein 1 0.0311 0.2415 0.2905
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0154 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Echinococcus granulosus cathepsin L 0.0102 0.0682 0.0821
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0689 0.0829
Loa Loa (eye worm) hypothetical protein 0.0311 0.2415 0.2905
Schistosoma mansoni hypothetical protein 0.0033 0.0112 0.0134
Loa Loa (eye worm) hypothetical protein 0.007 0.042 0.0505
Brugia malayi Heterochromatin protein 1 0.015 0.1084 0.1304
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0002 0.0004
Echinococcus granulosus intermediate filament protein 0.0085 0.0542 0.0652
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Brugia malayi PHD-finger family protein 0.0055 0.0297 0.0357
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0055
Loa Loa (eye worm) hypothetical protein 0.0072 0.043 0.0518
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0042 0.0051
Onchocerca volvulus 0.0276 0.2119 0.5218
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0085 0.0102
Echinococcus granulosus glutamate receptor 4 0.0042 0.0188 0.0226
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.003 0.009 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Loa Loa (eye worm) hypothetical protein 0.0039 0.0165 0.0198
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0095 0.0284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0192 0.1429 0.1299
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis chromobox protein, putative 0.015 0.1084 0.3588
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0546 0.0404
Brugia malayi Pre-SET motif family protein 0.0035 0.0125 0.0151
Schistosoma mansoni bromodomain containing protein 0.0138 0.0983 0.1183
Schistosoma mansoni lozenge 0.0063 0.0363 0.0437
Trypanosoma cruzi cysteine protease, putative 0.0102 0.0682 0.0821
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0835 0.2781
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0011 0.0013
Leishmania major trypanothione reductase 0.0037 0.0149 0.0495
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0215 0.0259
Plasmodium falciparum phosphodiesterase gamma, putative 0.0073 0.0439 0.2073
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0439 0.1434
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Schistosoma mansoni chromodomain helicase DNA binding protein 0.003 0.009 0.0108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0382 0.3001 0.361
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Toxoplasma gondii cathepsin CPC1 0.0095 0.0623 0.1304
Loa Loa (eye worm) hypothetical protein 0.0268 0.206 0.2478
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0071 0.0201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0095 0.0623 0.2048
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0149
Plasmodium falciparum serine repeat antigen 9 0.0095 0.0623 0.2939
Giardia lamblia Hypothetical protein 0.0095 0.0623 0.1285
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0073 0.0439 0.1464
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0597 0.4776 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0095 0.0623 0.2904
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0085 0.0102
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0625 0.0484
Mycobacterium tuberculosis Conserved protein 0.0192 0.1429 0.1299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0835 0.1004
Loa Loa (eye worm) heterochromatin protein 1 0.015 0.1084 0.1304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Echinococcus multilocularis cathepsin b 0.1024 0.8311 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0614 0.0739
Schistosoma mansoni ran 0.0021 0.0011 0.0013
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0042 0.0051
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Brugia malayi glutathione reductase 0.0037 0.0149 0.0179
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0073 0.0439 0.1464
Giardia lamblia Cathepsin B precursor 0.0382 0.3001 0.6274
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0042 0.0105
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0073 0.0439 0.0529
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0625 0.0484
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Giardia lamblia Hypothetical protein 0.0095 0.0623 0.1285
Echinococcus multilocularis cathepsin L cysteine protease 0.0276 0.2119 0.255
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Plasmodium falciparum phd finger protein, putative 0.0061 0.0339 0.1601
Brugia malayi PHD-finger family protein 0.0026 0.005 0.006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0178 0.0214
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0095 0.0623 0.2939
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0095 0.0623 0.2939
Echinococcus granulosus cathepsin L cysteine proteinase 0.0276 0.2119 0.255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1444 0.1738
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0042 0.0051
Loa Loa (eye worm) hypothetical protein 0.0073 0.0439 0.0529
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0095 0.0623 0.2939
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0125 0.0151
Brugia malayi jmjC domain containing protein 0.0079 0.0492 0.0592
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0835 0.1004
Mycobacterium tuberculosis Probable lipase LipE 0.0192 0.1429 0.1299
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Plasmodium vivax unspecified product 0.0095 0.0623 0.2939
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0218 0.1642 0.1975
Loa Loa (eye worm) hypothetical protein 0.0268 0.206 0.2478
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0105
Brugia malayi MH2 domain containing protein 0.0246 0.1873 0.2254
Schistosoma mansoni hypothetical protein 0.0045 0.0207 0.0249
Echinococcus granulosus cathepsin l1 0.0276 0.2119 0.255
Plasmodium falciparum glutathione reductase 0.0037 0.0149 0.0701
Echinococcus multilocularis lamin dm0 0.0085 0.0542 0.0652
Onchocerca volvulus 0.0276 0.2119 0.5218
Mycobacterium tuberculosis Conserved protein 0.0192 0.1429 0.1299
Onchocerca volvulus 0.0085 0.0542 0.1255
Loa Loa (eye worm) hypothetical protein 0.0042 0.0188 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0102 0.0682 0.0821
Echinococcus multilocularis lamin 0.0085 0.0542 0.0652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0268 0.206 0.6853
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.0395 0.0475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Echinococcus multilocularis muscleblind protein 0.0311 0.2415 0.2905
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0481 0.0578
Brugia malayi cathepsin L-like cysteine proteinase 0.0095 0.0623 0.0749
Loa Loa (eye worm) hypothetical protein 0.0104 0.0697 0.0839
Toxoplasma gondii cathepsin CPL 0.0276 0.2119 0.4437
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0108 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0536 0.1758
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.1444 0.1738
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0214
Leishmania major cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1464
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.1873 0.2254
Plasmodium falciparum serine repeat antigen 5 0.0095 0.0623 0.2939
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0108 0.0129
Echinococcus multilocularis peregrin 0.0066 0.0382 0.0459
Echinococcus multilocularis cathepsin L cysteine protease 0.0276 0.2119 0.255
Brugia malayi RNA, U transporter 1 0.008 0.0504 0.0607
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0329 0.0396
Schistosoma mansoni eyes absent homolog 0.009 0.0581 0.0699
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0042 0.0051
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126
Plasmodium vivax unspecified product 0.0102 0.0682 0.322
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0192 0.1429 0.1299
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Plasmodium falciparum cysteine proteinase falcipain 3 0.0276 0.2119 1
Mycobacterium tuberculosis Probable lipase LipD 0.0192 0.1429 0.1299
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Loa Loa (eye worm) PDE1B protein 0.0073 0.0439 0.0529
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Echinococcus granulosus importin subunit beta 1 0.0028 0.0072 0.0087
Brugia malayi RNA binding protein 0.0067 0.0393 0.0473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Plasmodium falciparum serine repeat antigen 4 0.0095 0.0623 0.2939
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Loa Loa (eye worm) hypothetical protein 0.009 0.0581 0.0699
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0102 0.0682 0.0821
Echinococcus granulosus muscleblind protein 0.0311 0.2415 0.2905
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0524 0.4175 0.5024
Plasmodium vivax vivapain-2 0.0276 0.2119 1
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0393 0.0473
Onchocerca volvulus 0.0028 0.0074 0.008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0074 0.0089
Echinococcus multilocularis cysteine protease 0.0276 0.2119 0.255
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0623 0.1285
Loa Loa (eye worm) hypothetical protein 0.1024 0.8311 1
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0042 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0149
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0108 0.0129
Plasmodium vivax importin-beta 2, putative 0.0028 0.0072 0.0342
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0046 0.0055
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0143 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0623 0.2048
Onchocerca volvulus 0.0268 0.206 0.5069
Plasmodium falciparum phosphodiesterase delta, putative 0.0073 0.0439 0.2073
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0073 0.0439 0.0529
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0439 0.0529
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0067 0.0188
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0192 0.1429 0.1719
Toxoplasma gondii ABC1 family protein 0.0192 0.1429 0.2991
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1464
Brugia malayi TAR-binding protein 0.0067 0.0393 0.0473
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Trypanosoma cruzi cysteine proteinase, putative 0.0102 0.0682 0.0821
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0337 0.0706
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0149 0.0179
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0218 0.1642 0.5471
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0339 0.071
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0215 0.0259
Plasmodium falciparum serine repeat antigen 3 0.0095 0.0623 0.2939
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0042 0.0199
Echinococcus multilocularis glutamate receptor 2 0.0063 0.0357 0.043
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0042 0.0199
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1434
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0002 0.0007
Echinococcus multilocularis transcription factor Dp 1 0.0126 0.0882 0.1061
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0623 0.0749
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0536 0.0644
Plasmodium vivax phosphodiesterase gamma, putative 0.0073 0.0439 0.2073
Loa Loa (eye worm) hypothetical protein 0.0153 0.1102 0.1326
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Schistosoma mansoni cathepsin B (C01 family) 0.0095 0.0623 0.0749
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0095 0.0284
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0073 0.0439 0.0529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0623 0.2048
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Plasmodium falciparum serine repeat antigen 2 0.0095 0.0623 0.2939
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.0445 0.0535
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0073 0.0439 0.0529
Brugia malayi Papain family cysteine protease containing protein 0.0102 0.0682 0.0821
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0061 0.0339 0.0408
Trichomonas vaginalis hypothetical protein 0.0025 0.0042 0.0105
Loa Loa (eye worm) hypothetical protein 0.0084 0.0536 0.0645
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0459 0.0552
Brugia malayi Papain family cysteine protease containing protein 0.0102 0.0682 0.0821
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0589 0.1935
Brugia malayi chromobox protein homolog 3 0.0084 0.0536 0.0645
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0105
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0129
Brugia malayi cathepsin F-like cysteine proteinase 0.0095 0.0623 0.0749
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0546 0.0404
Trypanosoma cruzi ISWI complex protein 0.0033 0.0112 0.0134
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0073 0.0439 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0276 0.2119 0.7051
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) < 17 nM Inhibition of serotonin N-acetyltransferase ChEMBL. 11448230

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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