TDR Targets

Basic information

Technical information

TDR Targets ID: 1363356
Name: phthalazino[1,2-b]quinazolin-8-one
MW: 247.251 | Formula: C15H9N3O
H donors: 0 H acceptors: 1 LogP: 2.04 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=c1c2ccccc2nc2n1ncc1c2cccc1
InChi: 1S/C15H9N3O/c19-15-12-7-3-4-8-13(12)17-14-11-6-2-1-5-10(11)9-16-18(14)15/h1-9H
InChiKey: WJVXOWLIUZTXHT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

8-phthalazino[1,2-b]quinazolinone
AF-399/40654094
Oprea1_744071
ZINC00351550
MLS000770630
SMR000343793
T0513-8482

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	RAB9A, member RAS oncogene family	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	Niemann-Pick disease, type C1	Starlite/ChEMBL	No references
Saccharomyces cerevisiae	protein transporter TIM23	Starlite/ChEMBL	No references
Homo sapiens	breast cancer 1, early onset	Starlite/ChEMBL	No references
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Candida albicans	import of proteins into mitochondrial matrix	Get druggable targets OG5_128152	All targets in OG5_128152
Entamoeba histolytica	Niemann-Pick C1 protein, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	Mitochondrial import inner membrane translocase subunit Tim23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Plasmodium knowlesi	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Toxoplasma gondii	mitochondrial inner membrane translocase subunit TIM17, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Candida albicans	potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Brugia malayi	Niemann-Pick C1 protein precursor	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K07003 Niemann Pick type C1, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	mitochondrial import inner membrane protein, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus granulosus	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Candida albicans	import of proteins into mitochondrial matrix	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Neospora caninum	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Theileria parva	mitochondrial import inner membrane translocase, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	Get druggable targets OG5_128152	All targets in OG5_128152
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma mansoni	niemann-pick C1 (NPC1)	Get druggable targets OG5_128206	All targets in OG5_128206

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Plasmodium falciparum	ras-related protein Rab-5B	RAB9A, member RAS oncogene family	201 aa	165 aa	30.9 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/INSR protein kinase	0.0516	0.1203	0.1203
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0464	0.1046	0.2224
Echinococcus multilocularis	cyclin dependent kinase 9	0.0176	0.0192	0.0193
Echinococcus granulosus	Immunoglobulin	0.0257	0.0433	0.092
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0277	0.0491	0.1428
Echinococcus granulosus	tyrosine kinase	0.0333	0.0659	0.14
Trichomonas vaginalis	CMGC family protein kinase	0.0464	0.1046	0.6031
Brugia malayi	Protein kinase domain containing protein	0.0765	0.1942	0.1942
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0199	0.026	0.0552
Schistosoma mansoni	serine/threonine protein kinase	0.0193	0.024	0.0572
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0911	0.2375	0.2378
Schistosoma mansoni	serine/threonine protein kinase	0.0259	0.0439	0.1077
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0277	0.0491	0.0491
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.0027	0.003
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Echinococcus multilocularis	activated cdc42 kinase 1	0.0792	0.2023	0.2026
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0178	0.0197	0.0418
Trichomonas vaginalis	STE family protein kinase	0.0684	0.17	1
Trypanosoma brucei	protein kinase, putative	0.0162	0.015	0.005
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.0173	0.0368
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0277	0.0491	0.0491
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0117	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0433	0.0433
Echinococcus granulosus	plexin a4	0.012	0.0026	0.0054
Echinococcus granulosus	tyrosine protein kinase otk	0.0117	0.0015	0.0032
Giardia lamblia	Kinase, NEK	0.0495	0.1139	0.6595
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Schistosoma mansoni	tyrosine kinase	0.0516	0.1203	0.302
Echinococcus granulosus	NCK adaptor protein	0.0141	0.0087	0.0185
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0539	0.127	0.4581
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0277	0.0491	0.1428
Trypanosoma brucei	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0186	0.0222	0.0338
Echinococcus multilocularis	roundabout 2	0.0386	0.0815	0.0816
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0395	0.0842	0.1789
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0509	0.1181	0.422
Loa Loa (eye worm)	TK protein kinase	0.0254	0.0423	0.0423
Trypanosoma brucei	cdc2-related kinase 1	0.0285	0.0517	0.1532
Echinococcus multilocularis	roundabout 2	0.0128	0.005	0.005
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0127	0.0046	0.0098
Echinococcus granulosus	casein kinase I alpha	0.0259	0.0439	0.0932
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.0022	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0222	0.0327	0.0327
Loa Loa (eye worm)	hypothetical protein	0.012	0.0024	0.0024
Echinococcus multilocularis	cyclin dependent kinase	0.0285	0.0517	0.0517
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0251	0.0416	0.0416
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0298	0.0553	0.0554
Entamoeba histolytica	protein kinase, putative	0.0145	0.0098	0.0613
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0509	0.1181	0.422
Echinococcus multilocularis	casein kinase I alpha	0.0259	0.0439	0.0439
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0178	0.0197	0.1404
Toxoplasma gondii	AGC kinase	0.0277	0.0491	0.3628
Entamoeba histolytica	protein kinase, putative	0.0464	0.1046	0.821
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.0098	0.021
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0989	0.2609	0.2612
Schistosoma mansoni	serine/threonine protein kinase	0.0601	0.1454	0.3658
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0213	0.0302	0.0641
Giardia lamblia	Kinase, NEK	0.0495	0.1139	0.6595
Schistosoma mansoni	serine/threonine protein kinase	0.0385	0.0814	0.203
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0199	0.026	0.026
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0178	0.0197	0.0197
Echinococcus granulosus	titin	0.0151	0.0117	0.0248
Brugia malayi	Protein kinase domain containing protein	0.0911	0.2375	0.2375
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0213	0.0302	0.0302
Onchocerca volvulus	Slit protein homolog	0.012	0.0024	0.0009
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0841	0.2168	0.2171
Echinococcus multilocularis	casein kinase I alpha	0.0259	0.0439	0.0439
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0663	0.1639	0.3484
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0418	0.0912	0.0913
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0285	0.0517	0.0517
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0765	0.1942	0.1942
Toxoplasma gondii	aurora kinase	0.0418	0.0912	0.7516
Brugia malayi	hypothetical protein	0.0186	0.0222	0.0222
Brugia malayi	Peroxidasin	0.0118	0.002	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0561	0.1335	0.3357
Brugia malayi	C1-like domain containing protein	0.0367	0.076	0.076
Brugia malayi	hypothetical protein	0.0269	0.0468	0.0468
Entamoeba histolytica	cell division protein kinase 2, putative	0.0285	0.0517	0.3965
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0437	0.0968	0.2057
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0129	0.0052	0.0111
Trypanosoma cruzi	casein kinase, putative	0.0259	0.0439	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0343	0.0687	0.0687
Giardia lamblia	Kinase, NEK	0.0495	0.1139	0.6595
Schistosoma mansoni	serine/threonine protein kinase	0.103	0.2731	0.6906
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0199	0.026	0.0726
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0418	0.0912	0.7131
Echinococcus granulosus	Protein kinase C brain isozyme	0.0193	0.024	0.0511
Echinococcus granulosus	mitogen activated protein kinase 14	0.0989	0.2609	0.5546
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0911	0.2375	0.2375
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Schistosoma mansoni	growth factor receptor-bound protein	0.0141	0.0087	0.0182
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0684	0.17	0.17
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0464	0.1046	0.3677
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0395	0.0842	0.1789
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0464	0.1046	0.1046
Onchocerca volvulus		0.0151	0.0117	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0792	0.2023	0.2023
Brugia malayi	hypothetical protein	0.015	0.0115	0.0115
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0145	0.0098	0.0098
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0765	0.1941	0.1944
Echinococcus granulosus	activated cdc42 kinase 1	0.0792	0.2023	0.4301
Echinococcus granulosus	roundabout 2	0.0128	0.005	0.0105
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0145	0.0098	0.0098
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0186	0.0222	0.0338
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Echinococcus multilocularis	protein kinase c iota type	0.0193	0.024	0.0241
Schistosoma mansoni	serine/threonine protein kinase	0.0509	0.1181	0.2964
Schistosoma mansoni	tyrosine kinase	0.0516	0.1203	0.302
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0145	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0352	0.0715	0.0715
Entamoeba histolytica	protein kinase domain containing protein	0.0464	0.1046	0.821
Brugia malayi	Immunoglobulin I-set domain containing protein	0.1417	0.3879	0.3879
Schistosoma mansoni	protein kinase	0.0129	0.0052	0.0094
Brugia malayi	Tyrosine-protein kinase abl-1	0.0493	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0468	0.0468
Trichomonas vaginalis	AGC family protein kinase	0.0418	0.0912	0.5214
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0911	0.2375	0.2375
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Echinococcus multilocularis		0.0315	0.0604	0.0605
Trypanosoma cruzi	casein kinase, putative	0.0259	0.0439	0.1217
Onchocerca volvulus		0.0259	0.0439	0.0424
Echinococcus granulosus	casein kinase I alpha	0.0259	0.0439	0.0932
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0663	0.1639	0.1641
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0459	0.1031	0.2192
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0222	0.0222
Echinococcus multilocularis	GTPase activating Rap:RanGAP domain 3	0.0186	0.0222	0.0222
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0293	0.0538	0.4138
Echinococcus multilocularis	rho associated protein kinase	0.0674	0.1672	0.1674
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0129	0.0052	0.0111
Schistosoma mansoni	tyrosine kinase	0.0891	0.2317	0.5855
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0513	0.1192	0.2535
Schistosoma mansoni	serine/threonine protein kinase	0.0496	0.1143	0.2868
Plasmodium falciparum	protein kinase, putative	0.0162	0.015	0.0119
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0199	0.026	0.117
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0199	0.026	0.0726
Echinococcus granulosus	NDR protein kinase	0.0145	0.0098	0.0208
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Echinococcus multilocularis	aurora kinase A	0.0418	0.0912	0.0913
Schistosoma mansoni	vav2	0.0143	0.0094	0.0199
Schistosoma mansoni	protein kinase	0.0418	0.0912	0.228
Echinococcus granulosus	cyclin dependent kinase 9	0.0176	0.0192	0.0409
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0199	0.026	0.1496
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.1253	0.3393	0.3393
Schistosoma mansoni	serine/threonine protein kinase	0.0117	0.0017	0.0005
Schistosoma mansoni	rap gtpase-activating protein	0.0186	0.0222	0.0524
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0911	0.2375	0.2363
Schistosoma mansoni	tyrosine kinase	0.0239	0.038	0.0927
Echinococcus granulosus	activin receptor type	0.1694	0.4704	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0195	0.0249	0.0249
Brugia malayi	serine/threonine kinase 12	0.0418	0.0912	0.0912
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0199	0.026	0.0494
Trypanosoma cruzi	cdc2-related kinase 1	0.0285	0.0517	0.1532
Echinococcus multilocularis	neuroglian	0.0333	0.0658	0.0659
Schistosoma mansoni	serine/threonine protein kinase	0.0674	0.1672	0.4214
Schistosoma mansoni	serine/threonine protein kinase	0.0539	0.127	0.3191
Echinococcus granulosus	roundabout 2	0.0386	0.0815	0.1731
Brugia malayi	Protein kinase domain	0.0129	0.0052	0.0052
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0199	0.026	0.0552
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.143	0.3918	0.8329
Entamoeba histolytica	protein kinase, putative	0.0539	0.127	1
Echinococcus multilocularis	cyclin dependent kinase 19	0.0888	0.2307	0.2311
Trypanosoma cruzi	cdc2-related kinase 3	0.0285	0.0517	0.1532
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0464	0.1046	0.1048
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0199	0.026	0.117
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0128	0.005	0.005
Brugia malayi	Protein kinase domain containing protein	0.0509	0.1181	0.1181
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0117	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0694	0.173	0.173
Trichomonas vaginalis	CK1 family protein kinase	0.0259	0.0439	0.2344
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.2578	0.2582
Brugia malayi	Protein kinase domain containing protein	0.0888	0.2307	0.2307
Trichomonas vaginalis	STE family protein kinase	0.0684	0.17	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0509	0.1181	0.422
Brugia malayi	SRC-1	0.0395	0.0842	0.0842
Schistosoma mansoni	tyrosine kinase	0.0239	0.038	0.0927
Echinococcus granulosus	protein kinase shaggy	0.0464	0.1046	0.2224
Schistosoma mansoni	protein kinase	0.0663	0.1639	0.413
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0989	0.2609	0.2612
Echinococcus multilocularis	cyclin dependent kinase 7	0.0385	0.0814	0.0815
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0199	0.026	0.117
Echinococcus multilocularis	activin receptor type	0.1694	0.4704	0.4711
Trichomonas vaginalis	CK1 family protein kinase	0.0259	0.0439	0.2344
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0277	0.0491	0.1428
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Brugia malayi	Protein kinase domain containing protein	0.1456	0.3994	0.3994
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0684	0.17	0.6324
Schistosoma mansoni	tyrosine kinase	0.0762	0.1932	0.4876
Onchocerca volvulus		0.0464	0.1046	0.1033
Schistosoma mansoni	serine/threonine protein kinase	0.0199	0.026	0.0622
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0946	0.2481	0.2484
Brugia malayi	Variant SH3 domain containing protein	0.0141	0.0087	0.0087
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0127	0.0046	0.0046
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0277	0.0491	0.1043
Echinococcus granulosus	titin	0.0151	0.0117	0.0248
Trypanosoma cruzi	casein kinase, putative	0.0259	0.0439	0.1217
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0146	0.0103	0.0103
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0199	0.026	0.026
Echinococcus granulosus	serine:threonine protein kinase N2	0.0145	0.0098	0.0208
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0539	0.127	0.4581
Echinococcus multilocularis	twitchin	0.0139	0.0083	0.0083
Giardia lamblia	Kinase, CAMK CAMKL	0.0175	0.0188	0.0823
Echinococcus granulosus	hemicentin 1	0.0117	0.0015	0.0032
Echinococcus granulosus	activated cdc42 kinase 1	0.0792	0.2023	0.4301
Entamoeba histolytica	protein kinase, putative	0.0418	0.0912	0.7131
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.083	0.2136	0.2136
Entamoeba histolytica	protein kinase, putative	0.0161	0.0145	0.0992
Loa Loa (eye worm)	hypothetical protein	0.032	0.0618	0.0618
Echinococcus granulosus	TGF-beta receptor type-1	0.0364	0.0749	0.1592
Entamoeba histolytica	protein kinase, putative	0.0129	0.0052	0.0247
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0418	0.0912	0.7291
Schistosoma mansoni	serine/threonine protein kinase	0.0158	0.0138	0.0312
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0684	0.17	0.6324
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Brugia malayi	Protein kinase domain containing protein	0.032	0.0618	0.0618
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0117	0.0015	0.0015
Echinococcus granulosus	c src tyrosine kinase	0.0239	0.038	0.0807
Brugia malayi	protein-tyrosine kinase	0.0333	0.0659	0.0659
Brugia malayi	cyclin-dependent kinase 9	0.016	0.0143	0.0143
Loa Loa (eye worm)	CMGC/CDK/CDK8 protein kinase	0.0888	0.2307	0.2307
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0259	0.0439	0.1217
Plasmodium vivax	NIMA-related protein kinase (Pfnek-1), putative	0.0495	0.1139	0.9584
Trichomonas vaginalis	CMGC family protein kinase	0.0509	0.1181	0.6845
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0128	0.005	0.005
Entamoeba histolytica	casein kinase 1, putative	0.0259	0.0439	0.3342
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0509	0.1181	0.1181
Loa Loa (eye worm)	hypothetical protein	0.0199	0.026	0.026
Echinococcus granulosus	mitogen activated protein kinase 11	0.0989	0.2609	0.5546
Schistosoma mansoni	hypothetical protein	0.0186	0.0222	0.0524
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0395	0.0842	0.1789
Entamoeba histolytica	protein kinase, putative	0.0129	0.0052	0.0247
Schistosoma mansoni	vesicular amine transporter	0.0257	0.0433	0.1063
Echinococcus granulosus	tyrosine protein kinase Blk	0.0333	0.0659	0.14
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.015	0.1032
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0128	0.005	0.005
Trichomonas vaginalis	CK1 family protein kinase	0.0259	0.0439	0.2344
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.0415	0.0902	0.0902
Schistosoma mansoni	cell adhesion molecule	0.0128	0.005	0.0087
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0684	0.17	0.1703
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.1253	0.3393	0.7214
Echinococcus multilocularis	casein kinase I delta	0.0259	0.0439	0.0439
Echinococcus granulosus	serine:threonine kinase SAD 1	0.0158	0.0138	0.0293
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0464	0.1046	0.3677
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.005	0.005
Schistosoma mansoni	tyrosine kinase	0.144	0.3947	1
Echinococcus multilocularis		0.0445	0.0991	0.0993
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0547	0.1294	0.1294
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0395	0.0842	0.1789
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Brugia malayi	P38 map kinase family protein 2	0.0989	0.2609	0.2609
Brugia malayi	EST embl\|AI107989\|AI107989 comes from the 3' UTR, putative	0.0561	0.1335	0.1335
Trichomonas vaginalis	AGC family protein kinase	0.0495	0.1139	0.6595
Brugia malayi	hypothetical protein	0.1253	0.3393	0.3393
Echinococcus granulosus	casein kinase I delta	0.0259	0.0439	0.0932
Brugia malayi	Protein kinase domain containing protein	0.0328	0.0643	0.0643
Brugia malayi	Tyrosine-protein kinase abl-1	0.041	0.0886	0.0886
Brugia malayi	Protein kinase domain containing protein	0.0539	0.127	0.127
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0468	0.0468
Echinococcus multilocularis	tyrosine protein kinase otk	0.0117	0.0015	0.0015
Echinococcus multilocularis	titin	0.0151	0.0117	0.0117
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0333	0.0659	0.14
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.0103	0.0224
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0117	0.0017	0.0017
Loa Loa (eye worm)	TK/ALK protein kinase	0.224	0.6324	0.6324
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0193	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0222	0.0222
Echinococcus granulosus	epidermal growth factor receptor	0.0287	0.052	0.1106
Trypanosoma cruzi	cdc2-related kinase 1	0.0285	0.0517	0.1532
Leishmania major	protein kinase, putative	0.0418	0.0912	0.3131
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.0339	0.0823
Echinococcus multilocularis	cyclin dependent kinase 1	0.0285	0.0517	0.0517
Trypanosoma cruzi	casein kinase, putative	0.0259	0.0439	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0429	0.0429
Schistosoma mansoni	protein kinase	0.0162	0.015	0.0343
Brugia malayi	Hr1 repeat family protein	0.0145	0.0098	0.0098
Giardia lamblia	Kinase, CAMK CAMKL	0.0175	0.0188	0.0823
Schistosoma mansoni	hypothetical protein	0.015	0.0115	0.0252
Echinococcus multilocularis	5' AMP activated protein kinase catalytic	0.0561	0.1335	0.1337
Brugia malayi	Protein kinase domain containing protein	0.0161	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0437	0.0968	0.0968
Schistosoma mansoni	serine/threonine protein kinase	0.0117	0.0017	0.0005
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0911	0.2375	0.2375
Entamoeba histolytica	protein kinase domain containing protein	0.0464	0.1046	0.821
Loa Loa (eye worm)	hypothetical protein	0.0366	0.0755	0.0755
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0128	0.005	0.0087
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0911	0.2375	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0277	0.0491	0.1043
Onchocerca volvulus		0.0118	0.002	0.0005
Echinococcus granulosus	casein kinase I delta	0.0259	0.0439	0.0932
Toxoplasma gondii	casein kinase I	0.0259	0.0439	0.3147
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0684	0.17	0.17
Onchocerca volvulus		0.102	0.2699	0.2688
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0127	0.0046	0.0079
Loa Loa (eye worm)	hypothetical protein	0.015	0.0115	0.0115
Loa Loa (eye worm)	gastrulation defective protein 1	0.0824	0.2118	0.2118
Brugia malayi	p70 ribosomal S6 kinase beta	0.0145	0.0098	0.0098
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0989	0.2609	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0277	0.0491	0.0491
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0277	0.0491	0.1428
Trichomonas vaginalis	AGC family protein kinase	0.0418	0.0912	0.5214
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Giardia lamblia	Kinase, CMGC GSK	0.0464	0.1046	0.6031
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0257	0.0433	0.1063
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.0098	0.021
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0547	0.1294	0.1294
Echinococcus granulosus	c-Jun N-terminal kinases	0.103	0.2731	0.5805
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0277	0.0491	0.0491
Echinococcus granulosus	growth factor receptor bound protein 2	0.0148	0.0107	0.0227
Echinococcus multilocularis	protein kinase shaggy	0.0464	0.1046	0.1048
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0539	0.127	0.4581
Schistosoma mansoni	neuroglian	0.0128	0.005	0.0087
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0117	0.0017	0.0036
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0117	0.0015	0.0015
Echinococcus multilocularis	peroxidasin	0.0118	0.002	0.0019
Plasmodium falciparum	protein serine/threonine kinase-1	0.0509	0.1181	1
Schistosoma mansoni	serine/threonine protein kinase	0.0193	0.024	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0015	0.0015
Echinococcus granulosus	TGF beta receptor type 1	0.0364	0.0749	0.1592
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0433	0.0433
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0395	0.0842	0.0843
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0464	0.1047	0.1047
Plasmodium falciparum	glycogen synthase kinase 3	0.0464	0.1046	0.8713
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Leishmania major	protein kinase A catalytic subunit	0.0277	0.0491	0.1428
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0277	0.0491	0.3384
Echinococcus multilocularis	transfer RNA-Thr	0.0792	0.2023	0.2026
Echinococcus multilocularis	roundabout 2	0.0128	0.005	0.005
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0605	0.1466	0.1466
Echinococcus multilocularis	TGF beta receptor type 1	0.0364	0.0749	0.075
Schistosoma mansoni	serine/threonine protein kinase	0.0285	0.0517	0.1275
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0315	0.0604	0.0604
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0539	0.127	0.4581
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0989	0.2609	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0117	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.023	0.0351	0.0351
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0199	0.026	0.0726
Giardia lamblia	Kinase, CMGC GSK	0.0464	0.1046	0.6031
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0162	0.015	0.005
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0285	0.0517	0.1098
Onchocerca volvulus		0.032	0.0618	0.0604
Trichomonas vaginalis	CAMK family protein kinase	0.0199	0.026	0.126
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0418	0.0912	0.7131
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0141	0.0087	0.0087
Entamoeba histolytica	protein kinase, putative	0.0199	0.026	0.191
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0277	0.0491	0.0491
Schistosoma mansoni	protein kinase	0.0663	0.1639	0.413
Brugia malayi	Protein kinase domain containing protein	0.224	0.6326	0.6326
Entamoeba histolytica	protein kinase domain containing protein	0.016	0.0143	0.0968
Giardia lamblia	Kinase, CMGC CDK	0.0285	0.0517	0.2817
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0141	0.0087	0.0087
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0199	0.026	0.0726
Echinococcus multilocularis	calcium dependent protein kinase	0.0135	0.0071	0.0071
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0298	0.0555	0.118
Trichomonas vaginalis	CMGC family protein kinase	0.0285	0.0517	0.2817
Schistosoma mansoni	serine/threonine protein kinase	0.0277	0.0491	0.1209
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.0364	0.0749	0.075
Schistosoma mansoni	serine/threonine protein kinase	0.0277	0.0491	0.1209
Echinococcus granulosus	twitchin	0.0397	0.0848	0.1801
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0285	0.0517	0.0517
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0513	0.1192	0.1194
Schistosoma mansoni	serine/threonine protein kinase	0.0158	0.0138	0.0312
Trypanosoma brucei	casein kinase I, isoform 2	0.0259	0.0439	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0015	0.0015
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0285	0.0517	0.1532
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0277	0.0491	0.3051
Entamoeba histolytica	protein kinase, putative	0.0145	0.01	0.0626
Onchocerca volvulus	Tyrosine kinase homolog	0.1194	0.3217	0.3207
Echinococcus multilocularis	tyrosine protein kinase shark	0.0178	0.0197	0.0197
Schistosoma mansoni	serine/threonine protein kinase	0.0911	0.2375	0.6001
Echinococcus multilocularis	hemicentin 1	0.0117	0.0015	0.0015
Giardia lamblia	Kinase, STE STE20	0.0684	0.17	1
Echinococcus granulosus	protein kinase c epsilon type	0.0193	0.024	0.0511
Entamoeba histolytica	protein kinase, putative	0.0145	0.0098	0.0613
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0464	0.1046	0.2622
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0277	0.0491	0.1043
Schistosoma mansoni	nephrin	0.0128	0.005	0.0087
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.0098	0.021
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Brugia malayi	SH2 domain containing protein	0.0178	0.0197	0.0197
Echinococcus granulosus	cyclin dependent kinase 5	0.0285	0.0517	0.1098
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0513	0.1192	0.1194
Schistosoma mansoni	adapter molecule crk	0.0141	0.0087	0.0182
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.0143	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0429	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0475	0.1081	0.1081
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0385	0.0814	0.0814
Brugia malayi	Sex muscle abnormal protein 5	0.0141	0.0087	0.0087
Loa Loa (eye worm)	CAMK/CAMKL/AMPK protein kinase	0.0561	0.1335	0.1335
Echinococcus granulosus	roundabout 2	0.0128	0.005	0.0105
Schistosoma mansoni	tyrosine kinase	0.0287	0.052	0.1284
Echinococcus multilocularis	protein tyrosine kinase	0.144	0.3947	0.3953
Schistosoma mansoni	serine/threonine protein kinase	0.0765	0.1942	0.49
Loa Loa (eye worm)	TK protein kinase	0.0589	0.1417	0.1417
Brugia malayi	Variant SH3 domain containing protein	0.0141	0.0087	0.0087
Schistosoma mansoni	serine/threonine protein kinase	0.0139	0.0083	0.0171
Echinococcus multilocularis	slit 2 protein	0.012	0.0024	0.0024
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0251	0.0416	0.0416
Leishmania major	casein kinase, putative	0.0259	0.0439	0.1217
Brugia malayi	Fibronectin type III domain containing protein	0.0269	0.0468	0.0468
Brugia malayi	Temporarily assigned gene name protein 59	0.0186	0.0222	0.0222
Trypanosoma brucei	cdc2-related kinase 3	0.0285	0.0517	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0087	0.0087
Plasmodium falciparum	NIMA related kinase 1	0.0495	0.1139	0.9604
Brugia malayi	Protein kinase domain containing protein	0.0516	0.1203	0.1203
Echinococcus granulosus	tyrosine protein kinase shark	0.0178	0.0197	0.0418
Schistosoma mansoni	serine/threonine protein kinase	0.1253	0.3393	0.8592
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0151	0.0117	0.0117
Echinococcus multilocularis	cyclin dependent kinase 9	0.016	0.0143	0.0143
Onchocerca volvulus		0.0178	0.0197	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0118	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.015	0.0115	0.0115
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Leishmania major	protein kinase, putative	0.0199	0.026	0.0494
Entamoeba histolytica	protein kinase domain containing protein	0.0539	0.127	1
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.103	0.2731	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0015	0.0015
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0254	0.0423	0.0423
Onchocerca volvulus		0.0295	0.0545	0.053
Echinococcus granulosus	peroxidasin	0.0118	0.002	0.0041
Brugia malayi	RhoGAP domain containing protein	0.0127	0.0046	0.0046
Giardia lamblia	Aurora kinase	0.0418	0.0912	0.5214
Onchocerca volvulus		0.0178	0.0197	0.0182
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0431	0.095	0.3285
Loa Loa (eye worm)	IKK protein kinase	0.3477	1	1
Entamoeba histolytica	protein kinase, putative	0.0199	0.026	0.191
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0367	0.076	0.076
Onchocerca volvulus		0.3477	1	1
Loa Loa (eye worm)	hypothetical protein	0.0298	0.0555	0.0555
Schistosoma mansoni	tyrosine kinase	0.0188	0.0228	0.0539
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.016	0.0143	0.0143
Loa Loa (eye worm)	AUR protein kinase	0.0418	0.0912	0.0912
Schistosoma mansoni	serine/threonine protein kinase	0.0158	0.0138	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0462	0.0462
Brugia malayi	probable protein kinase	0.0501	0.1157	0.1157
Loa Loa (eye worm)	CAMK protein kinase	0.0151	0.0117	0.0117
Brugia malayi	putative serine/threonine kinase SADA gamma	0.0158	0.0138	0.0138
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0252	0.0416	0.0884
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0277	0.0491	0.0491
Entamoeba histolytica	protein kinase , putative	0.0418	0.0912	0.7131
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0513	0.1192	0.2535
Loa Loa (eye worm)	hypothetical protein	0.0295	0.0545	0.0545
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0528	0.1237	0.2629
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0145	0.0098	0.0098
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0399	0.0853	0.0853
Echinococcus granulosus	dual specificity mitogen activated protein	0.0684	0.17	0.3615
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0509	0.1181	0.1182
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Trypanosoma cruzi	aurora B kinase, putative	0.0418	0.0912	0.3131
Schistosoma mansoni	serine/threonine protein kinase	0.0419	0.0913	0.2283
Echinococcus multilocularis	tyrosine kinase	0.0178	0.0197	0.0197
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0395	0.0842	0.0843
Loa Loa (eye worm)	SRC-1	0.0395	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.015	0.0115	0.0115
Plasmodium falciparum	protein kinase 5	0.0285	0.0517	0.3631
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0277	0.0491	0.0491
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Loa Loa (eye worm)	hypothetical protein	0.0439	0.0974	0.0974
Echinococcus multilocularis	MAM	0.015	0.0115	0.0114
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0547	0.1294	0.1294
Entamoeba histolytica	protein kinase, putative	0.0539	0.127	1
Brugia malayi	hypothetical protein	0.0256	0.0429	0.0429
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0989	0.2609	1
Echinococcus granulosus	protein tyrosine kinase	0.144	0.3947	0.8391
Brugia malayi	Cam kinase protein 1	0.0199	0.026	0.026
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0605	0.1466	0.3116
Echinococcus multilocularis	casein kinase i	0.0259	0.0439	0.0439
Onchocerca volvulus		0.0178	0.0197	0.0182
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0117	0.0015	0.0015
Echinococcus multilocularis	Immunoglobulin	0.0257	0.0433	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0277	0.0491	0.0491
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0547	0.1294	0.2751
Brugia malayi	plexin A	0.012	0.0026	0.0026
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0127	0.0046	0.0046
Schistosoma mansoni	vam6/vps39 related	0.0186	0.0222	0.0524
Echinococcus multilocularis	cyclin dependent kinase 5	0.0285	0.0517	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0445	0.0991	0.0991
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0395	0.0842	0.1789
Schistosoma mansoni	serine/threonine protein kinase	0.0193	0.024	0.0572
Schistosoma mansoni	tyrosine kinase	0.0188	0.0228	0.0539
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0129	0.0052	0.0052
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0395	0.0842	0.0843
Echinococcus multilocularis	epidermal growth factor receptor	0.0287	0.052	0.0521
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0199	0.026	0.026
Brugia malayi	serine/threonine-protein kinase PAK 7	0.083	0.2136	0.2136
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0366	0.0755	0.1605
Echinococcus granulosus	lachesin	0.0117	0.0015	0.0032
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0395	0.0842	0.0843
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0989	0.2609	0.2609
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0464	0.1046	0.8649
Echinococcus granulosus	N chimaerin	0.0127	0.0046	0.0098
Echinococcus granulosus	raf serine:threonine protein kinase	0.0146	0.0103	0.022
Echinococcus granulosus	cyclin dependent kinase 19	0.0888	0.2307	0.4905
Schistosoma mansoni	protein kinase	0.0663	0.1639	0.413
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0145	0.0098	0.0098
Schistosoma mansoni	protein kinase	0.0986	0.2599	0.6572
Loa Loa (eye worm)	CAMK/CAMKL/BRSK protein kinase	0.0158	0.0138	0.0138
Onchocerca volvulus		0.0674	0.1672	0.1659
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0162	0.015	0.005
Loa Loa (eye worm)	hypothetical protein	0.0792	0.2023	0.2023
Toxoplasma gondii	AGC kinase	0.0277	0.0491	0.3628
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0145	0.0098	0.0098
Schistosoma mansoni	serine/threonine protein kinase	0.0418	0.0912	0.228
Schistosoma mansoni	serine/threonine protein kinase	0.0151	0.0117	0.0258
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0946	0.2481	0.5274
Brugia malayi	cell division control protein 2 homolog	0.0285	0.0517	0.0517
Echinococcus granulosus	casein kinase I alpha	0.0259	0.0439	0.0932
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0145	0.0098	0.0098
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0239	0.038	0.0927
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0402	0.0864	0.0864
Trichomonas vaginalis	AGC family protein kinase	0.0418	0.0912	0.5214
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0285	0.0517	0.1532
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0841	0.2168	0.4609
Entamoeba histolytica	tyrosin kinase, putative	0.0125	0.0041	0.0153
Loa Loa (eye worm)	TK/ROR protein kinase	0.0174	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0374	0.078	0.078
Loa Loa (eye worm)	hypothetical protein	0.1991	0.5585	0.5585
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0285	0.0517	0.0517
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0174	0.0186	0.0395
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.032	0.0618	0.0618
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0765	0.1941	0.4127
Schistosoma mansoni	serine/threonine protein kinase	0.0277	0.0491	0.1209
Brugia malayi	Stress-activated protein kinase jnk-1	0.103	0.2731	0.2731
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Schistosoma mansoni	tyrosine kinase	0.0513	0.1192	0.2994
Schistosoma mansoni	tyrosine kinase	0.0188	0.0228	0.0539
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0277	0.0491	0.1428
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0143	0.0093	0.0575
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0162	0.015	0.0483
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0259	0.0439	0.0439
Schistosoma mansoni	cell adhesion molecule	0.031	0.059	0.146
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0222	0.0222
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0539	0.127	0.127
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0127	0.0046	0.0079
Brugia malayi	Protein kinase domain containing protein	0.1963	0.5503	0.5503
Echinococcus granulosus	aurora kinase A	0.0418	0.0912	0.1938
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0174	0.0186	0.0186
Entamoeba histolytica	protein kinase, putative	0.0161	0.0145	0.0992
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0298	0.0553	0.1176
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0117	0.0015	0.0015
Schistosoma mansoni	tyrosine kinase	0.0366	0.0755	0.1881
Echinococcus granulosus	5' AMP activated protein kinase catalytic	0.0561	0.1335	0.2838
Plasmodium vivax	protein kinase Crk2	0.0285	0.0517	0.3311
Schistosoma mansoni	serine/threonine protein kinase	0.0888	0.2307	0.583
Echinococcus granulosus	insulin receptor	0.0516	0.1203	0.2556
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Loa Loa (eye worm)	plexin A	0.012	0.0026	0.0026
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0295	0.0545	0.0545
Brugia malayi	serine/threonine protein kinase 6	0.0418	0.0912	0.0912
Brugia malayi	serine/threonine-protein kinase 6	0.0418	0.0912	0.0912
Schistosoma mansoni	serine/threonine kinase	0.0145	0.0098	0.021
Trichomonas vaginalis	STE family protein kinase	0.0495	0.1139	0.6595
Loa Loa (eye worm)	hypothetical protein	0.0475	0.1081	0.1081
Leishmania major	protein kinase, putative	0.0509	0.1181	0.422
Loa Loa (eye worm)	hypothetical protein	0.0304	0.0571	0.0571
Brugia malayi	Protein kinase domain containing protein	0.0178	0.0197	0.0197
Schistosoma mansoni	kinase	0.016	0.0143	0.0323
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0145	0.0098	0.0098
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0277	0.0491	0.1428
Echinococcus granulosus	calcium dependent protein kinase	0.0135	0.0071	0.015
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0196	0.0249	0.0451
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.1963	0.5503	0.5503
Plasmodium vivax	serine/threonine kinase-1, putative	0.0509	0.1181	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Schistosoma mansoni	nephrin	0.0345	0.0693	0.1722
Onchocerca volvulus		0.0304	0.0571	0.0556
Schistosoma mansoni	serine/threonine protein kinase	0.0509	0.1181	0.2964
Brugia malayi	protein kinase C II.	0.0193	0.024	0.024
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.025	0.0411	0.0873
Schistosoma mansoni	growth factor receptor-bound protein	0.0148	0.0107	0.0233
Entamoeba histolytica	protein kinase, putative	0.0254	0.0423	0.3215
Schistosoma mansoni	titin	0.0151	0.0117	0.0258
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0589	0.1417	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0374	0.078	0.078
Trypanosoma brucei	aurora B kinase	0.0418	0.0912	0.3131
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0186	0.0222	0.0338
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0293	0.0538	0.4138
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0418	0.0912	0.7421
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.0022	0.0022
Onchocerca volvulus		0.0256	0.0429	0.0414
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0129	0.0052	0.0052
Entamoeba histolytica	protein kinase, putative	0.0143	0.0093	0.0575
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0989	0.2609	0.2612
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0199	0.026	0.026
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0395	0.0842	0.1789
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0117	0.0015	0.0015
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0509	0.1181	0.422
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.1253	0.3393	0.3398
Echinococcus granulosus	protein kinase c iota type	0.0193	0.024	0.0511
Schistosoma mansoni	serine/threonine protein kinase	0.0385	0.0814	0.203
Brugia malayi	casein kinase 1, delta	0.0259	0.0439	0.0439
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0496	0.1143	0.1144
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0399	0.0853	0.0853
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0129	0.0052	0.0052
Schistosoma mansoni	protein kinase	0.0605	0.1466	0.369
Schistosoma mansoni	tyrosine kinase	0.0395	0.0842	0.2102
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0285	0.0517	0.3866
Schistosoma mansoni	protein kinase C mu	0.0367	0.076	0.1895
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0199	0.026	0.117
Entamoeba histolytica	casein kinase, putative	0.0259	0.0439	0.3342
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0464	0.1047	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0015	0.0015
Entamoeba histolytica	protein kinase domain containing protein	0.0418	0.0912	0.7131
Brugia malayi	Protein kinase domain containing protein	0.0285	0.0517	0.0517
Brugia malayi	Protein kinase domain containing protein	0.0605	0.1466	0.1466
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0496	0.1143	0.2429
Echinococcus multilocularis	hemicentin 1	0.0117	0.0015	0.0015
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0509	0.1181	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0547	0.1294	0.1296
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Echinococcus granulosus	protein kinase	0.0315	0.0604	0.1284
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0395	0.0842	0.0843
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0684	0.17	0.6324
Schistosoma mansoni	tyrosine kinase	0.0215	0.0308	0.0745
Schistosoma mansoni	protein kinase	0.0986	0.2599	0.6572
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.025	0.0411	0.0411
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0199	0.026	0.0552
Echinococcus granulosus	contactin	0.0128	0.005	0.0105
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0493	0.1134	0.1135
Echinococcus granulosus	neuroglian	0.0128	0.005	0.0105
Brugia malayi	protein C17H12.11	0.0256	0.0429	0.0429
Echinococcus granulosus	protein kinase C gamma type	0.0145	0.0098	0.0208
Brugia malayi	SH2 domain containing protein	0.0178	0.0197	0.0197
Echinococcus granulosus	tyrosine protein kinase Srms	0.0178	0.0197	0.0418
Onchocerca volvulus		0.0136	0.0073	0.0057
Echinococcus granulosus	epidermal growth factor receptor	0.0287	0.052	0.1106
Leishmania major	protein kinase, putative	0.0509	0.1181	0.422
Schistosoma mansoni	hypothetical protein	0.015	0.0115	0.0252
Echinococcus granulosus	tyrosine protein kinase HCK	0.0254	0.0423	0.0899
Toxoplasma gondii	histone kinase SNF1, putative	0.0158	0.0138	0.0369
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0605	0.1466	0.1468
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0366	0.0755	0.0756
Echinococcus multilocularis	c src tyrosine kinase	0.0239	0.038	0.038
Echinococcus multilocularis	casein kinase I alpha	0.0259	0.0439	0.0439
Leishmania major	protein kinase, putative	0.0162	0.015	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0418	0.0912	0.5214
Brugia malayi	intracellular kinase	0.0464	0.1046	0.1046
Schistosoma mansoni	tyrosine kinase	0.0395	0.0842	0.2102
Echinococcus multilocularis	insulin receptor	0.0516	0.1203	0.1204
Onchocerca volvulus		0.0162	0.0149	0.0134
Echinococcus multilocularis	protein kinase c epsilon type	0.0193	0.024	0.0241
Echinococcus multilocularis	plexin a4	0.012	0.0026	0.0026
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0128	0.005	0.0105
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0287	0.052	0.1106
Trypanosoma cruzi	casein kinase, putative	0.0259	0.0439	0.1217
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0148	0.058
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0986	0.2599	0.2603
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.103	0.2731	0.2731
Trichomonas vaginalis	STE family protein kinase	0.0684	0.17	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Schistosoma mansoni	protein kinase	0.0364	0.0749	0.1866
Giardia lamblia	Kinase, AGC PKA	0.0277	0.0491	0.266
Onchocerca volvulus		0.0611	0.1483	0.147
Brugia malayi	EGF-like domain containing protein	0.012	0.0024	0.0024
Echinococcus granulosus	slit 2 protein	0.012	0.0024	0.0051
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0259	0.0439	0.0439
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0117	0.0015	0.0015
Echinococcus multilocularis	death associated protein kinase 1	0.3472	0.9985	1
Brugia malayi	Prion-like-	0.0117	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0015	0.0015
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0145	0.0098	0.0098
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0468	0.0468
Schistosoma mansoni	protein kinase	0.0129	0.0052	0.0094
Entamoeba histolytica	protein kinase domain containing protein	0.0125	0.0041	0.0153
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0186	0.0222	0.0524
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0509	0.1181	0.422
Onchocerca volvulus		0.0178	0.0197	0.0182
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0464	0.1046	0.1046
Brugia malayi	Protein kinase domain containing protein	0.0178	0.0197	0.0197
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Brugia malayi	Variant SH3 domain containing protein	0.0127	0.0046	0.0046
Trypanosoma brucei	protein kinase, putative	0.0464	0.1046	0.3677
Onchocerca volvulus		0.0178	0.0197	0.0182
Schistosoma mansoni	serine/threonine protein kinase	0.0158	0.0138	0.0312
Loa Loa (eye worm)	TK protein kinase	0.0333	0.0659	0.0659
Schistosoma mansoni	atypical protein kinase C	0.0193	0.024	0.0572
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.1417	0.3879	0.3879
Loa Loa (eye worm)	AUR protein kinase	0.0418	0.0912	0.0912
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0496	0.1143	0.1143
Onchocerca volvulus		0.015	0.0115	0.0099
Echinococcus granulosus	MAM	0.015	0.0115	0.0243
Schistosoma mansoni	nck2/grb4	0.0141	0.0087	0.0182
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0192	0.0239	0.0239
Echinococcus multilocularis	lachesin	0.0117	0.0015	0.0015
Entamoeba histolytica	p21-activated kinase	0.0145	0.01	0.0626
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0158	0.0138	0.0933
Brugia malayi	Furin-like cysteine rich region family protein	0.0287	0.052	0.052
Schistosoma mansoni	protein kinase	0.0315	0.0604	0.1497
Schistosoma mansoni	protein kinase	0.0129	0.0052	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0178	0.0197	0.0197
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0395	0.0842	0.0843
Onchocerca volvulus		0.0196	0.0249	0.0234
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0257	0.0433	0.1063
Echinococcus granulosus	tyrosine kinase	0.0178	0.0197	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0128	0.005	0.005
Schistosoma mansoni	serine/threonine protein kinase	0.0298	0.0553	0.1368
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0418	0.0912	0.1938
Echinococcus granulosus	cyclin dependent kinase 7	0.0385	0.0814	0.173
Echinococcus multilocularis	epidermal growth factor receptor	0.0287	0.052	0.0521
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0277	0.0491	0.3628
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0333	0.0659	0.0659
Schistosoma mansoni	tyrosine kinase	0.0178	0.0197	0.0461
Echinococcus granulosus	cyclin dependent kinase 1	0.0285	0.0517	0.1098
Brugia malayi	Protein kinase domain containing protein	0.0178	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0429	0.0429
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0241	0.0386	0.0386
Brugia malayi	protein unc-22	0.0151	0.0117	0.0117
Echinococcus granulosus	defective proboscis extension response	0.0257	0.0433	0.092
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0462	0.0462
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0129	0.0052	0.0111
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0241	0.0386	0.0819
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0333	0.0659	0.0659
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0259	0.0439	0.0439
Schistosoma mansoni	tyrosine kinase	0.0287	0.052	0.1284
Echinococcus multilocularis	PAK box P21 Rho binding	0.0129	0.0052	0.0052
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0161	0.0145	0.0145
Echinococcus multilocularis	casein kinase I delta	0.0259	0.0439	0.0439
Echinococcus granulosus	GTPase activating Rap:RanGAP domain 3	0.0186	0.0222	0.0471
Echinococcus granulosus	rho-associated protein kinase 1	0.0674	0.1672	0.3554
Trichomonas vaginalis	CMGC family protein kinase	0.0285	0.0517	0.2817
Giardia lamblia	Kinase, AGC AKT	0.0415	0.0902	0.5157
Trichomonas vaginalis	AGC family protein kinase	0.0277	0.0491	0.266
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0367	0.076	0.076
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0986	0.2599	0.5526
Echinococcus granulosus	cyclin dependent kinase 9	0.016	0.0143	0.0303
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0395	0.0842	0.0843
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.005	0.005
Echinococcus multilocularis	Immunoglobulin	0.0257	0.0433	0.0434
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0601	0.1454	0.1454
Echinococcus multilocularis	NCK adaptor protein	0.0148	0.0107	0.0107
Trichomonas vaginalis	AGC family protein kinase	0.0161	0.0145	0.0564
Brugia malayi	Protein kinase domain containing protein	0.0145	0.0098	0.0098
Onchocerca volvulus		0.0186	0.0222	0.0206
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0128	0.005	0.005
Schistosoma mansoni	cell adhesion molecule	0.0128	0.005	0.0087
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0277	0.0491	0.1428
Echinococcus multilocularis	serine:threonine kinase SAD 1	0.0158	0.0138	0.0138
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0145	0.0098	0.0098
Echinococcus multilocularis	neuroglian	0.0128	0.005	0.005
Trichomonas vaginalis	CMGC family protein kinase	0.0464	0.1046	0.6031
Echinococcus granulosus	casein kinase i	0.0259	0.0439	0.0932
Giardia lamblia	Kinase, CMGC CDK	0.0285	0.0517	0.2817
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0418	0.0912	0.7131
Trichomonas vaginalis	CAMK family protein kinase	0.0158	0.0138	0.052
Schistosoma mansoni	protein kinase	0.0399	0.0853	0.213
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0141	0.0087	0.0182
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0395	0.0842	0.1789
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0333	0.0659	0.0659
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0145	0.0098	0.0208
Trichomonas vaginalis	AGC family protein kinase	0.0145	0.0098	0.0277
Loa Loa (eye worm)	TK/FER protein kinase	0.0178	0.0197	0.0197
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0199	0.026	0.1496
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0199	0.026	0.117
Schistosoma mansoni	tyrosine kinase	0.0164	0.0156	0.0357
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0128	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0259	0.0437	0.0437
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0989	0.2609	1
Echinococcus multilocularis	N chimaerin	0.0127	0.0046	0.0046
Giardia lamblia	Kinase, CMGC CLK	0.0509	0.1181	0.6845
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0161	0.0145	0.003
Schistosoma mansoni	protein kinase	0.0259	0.0439	0.1077
Entamoeba histolytica	cell division protein kinase 2, putative	0.0302	0.0567	0.4366
Loa Loa (eye worm)	hypothetical protein	0.0295	0.0545	0.0545
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0186	0.0222	0.0524
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0199	0.026	0.026
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0287	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0468	0.0468
Onchocerca volvulus		0.0178	0.0197	0.0182
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.032	0.0618	0.0618
Brugia malayi	Serine/threonine-protein kinase SULU	0.1253	0.3393	0.3393
Schistosoma mansoni	tyrosine kinase	0.0287	0.052	0.1284
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0128	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0022	0.0022
Echinococcus granulosus	hypothetical protein	0.0445	0.0991	0.2107
Schistosoma mansoni	protein kinase	0.0684	0.17	0.4286
Loa Loa (eye worm)	TK/FAK protein kinase	0.1456	0.3994	0.3994
Giardia lamblia	Kinase, CK1 Casein kinase	0.0259	0.0439	0.2344
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0395	0.0842	0.0843
Echinococcus granulosus	dual specificity	0.0539	0.127	0.2699
Entamoeba histolytica	protein kinase, putative	0.0418	0.0912	0.7131
Brugia malayi	Protein kinase domain containing protein	0.0178	0.0197	0.0197
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0989	0.2609	0.2612
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0015	0.0015
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0162	0.015	0.005
Entamoeba histolytica	protein kinase, putative	0.0145	0.01	0.0626
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0601	0.1454	0.1454
Echinococcus multilocularis	cyclin dependent kinase 1	0.0285	0.0517	0.0517
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0193	0.024	0.0241
Brugia malayi	hypothetical protein	0.0178	0.0197	0.0197
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0277	0.0491	0.1428
Schistosoma mansoni	serine/threonine protein kinase	0.0298	0.0553	0.1368
Trichomonas vaginalis	CMGC family protein kinase	0.0285	0.0517	0.2817
Echinococcus granulosus	Vam6:Vps39 protein	0.0186	0.0222	0.0471
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0151	0.0117	0.0117
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.0022	0.0021
Loa Loa (eye worm)	TK/ABL protein kinase	0.0841	0.2168	0.2168
Brugia malayi	Protein kinase domain containing protein	0.0145	0.0098	0.0098
Schistosoma mansoni	serine/threonine protein kinase	0.0285	0.0517	0.1275
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0528	0.1237	0.1239
Echinococcus granulosus	cyclin dependent kinase	0.0285	0.0517	0.1098
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0199	0.026	0.026
Trypanosoma cruzi	cdc2-related kinase 3	0.0285	0.0517	0.1532
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0277	0.0491	0.1428
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0141	0.0087	0.0087
Brugia malayi	Protein kinase domain containing protein	0.0251	0.0416	0.0416
Toxoplasma gondii	NIMA-related protein kinase NIMA1	0.0495	0.1139	0.9618
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0199	0.026	0.1496
Plasmodium vivax	casein kinase 1, putative	0.0259	0.0439	0.2526
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0395	0.0842	0.0843
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0464	0.1046	0.8761
Schistosoma mansoni	protein kinase	0.0501	0.1157	0.2904
Echinococcus granulosus	dual specificity protein kinase clk2	0.0509	0.1181	0.2509
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.032	0.0618	0.0618
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0509	0.1181	0.422
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0195	0.0249	0.0249
Echinococcus multilocularis	dual specificity	0.0539	0.127	0.1272
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0145	0.0098	0.0208
Trichomonas vaginalis	AGC family protein kinase	0.0145	0.0098	0.0277
Brugia malayi	casein kinase I	0.0259	0.0439	0.0439
Entamoeba histolytica	hypothetical protein	0.0539	0.127	1
Loa Loa (eye worm)	AUR protein kinase	0.0418	0.0912	0.0912
Echinococcus multilocularis	serine threonine protein kinase	0.0145	0.0098	0.0098
Plasmodium falciparum	casein kinase 1	0.0259	0.0439	0.2884
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0117	0.0015	0.0015
Echinococcus granulosus	neuroglian	0.0333	0.0658	0.1399
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0257	0.0433	0.0434

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 15 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim23-1 yeast via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463212, AID463216, AID504657, AID504672]	ChEMBL.	No reference
Potency (functional)	= 2.2387 um	PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.3323 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3489 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	20.5878 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	23.9341 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	28.1838 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1490406

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1363356