TDR Targets

Basic information

Technical information

TDR Targets ID: 1369359
Name: 1-[3-(4-chlorophenyl)sulfanyl-2-methylpropyl] -3-(3-methylphenyl)thiourea
MW: 364.956 | Formula: C18H21ClN2S2
H donors: 1 H acceptors: 0 LogP: 5.96 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(CSc1ccc(cc1)Cl)CNC(=Nc1cccc(c1)C)S
InChi: 1S/C18H21ClN2S2/c1-13-4-3-5-16(10-13)21-18(22)20-11-14(2)12-23-17-8-6-15(19)7-9-17/h3-10,14H,11-12H2,1-2H3,(H2,20,21,22)
InChiKey: LNRBQWHWBGLVER-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[3-(4-chlorophenyl)sulfanyl-2-methyl-propyl]-3-(3-methylphenyl)thiourea
1-[3-[(4-chlorophenyl)thio]-2-methylpropyl]-3-(3-methylphenyl)thiourea
1-[3-[(4-chlorophenyl)thio]-2-methyl-propyl]-3-(3-methylphenyl)thiourea
MLS000689555
N-{3-[(4-chlorophenyl)thio]-2-methylpropyl}-N'-(3-methylphenyl)thiourea
SMR000311593

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	guanylate cyclase, putative	0.0024	0.0056	0.0533
Entamoeba histolytica	hypothetical protein	0.0107	0.0465	0.5158
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0025	0.0061	0.0061
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0027	0.0194
Brugia malayi	nuclear receptor NHR-88	0.0086	0.0363	0.139
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0164	0.0628
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0056	0.0214	0.0822
Echinococcus granulosus	geminin	0.0205	0.0942	0.0942
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0055	0.0209	0.0802
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0086	0.0363	0.139
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0043	0.0163
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0419	0.0419
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0086	0.0363	0.386
Echinococcus granulosus	adam	0.0026	0.0066	0.0066
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0185	0.5779
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0287	0.1098
Schistosoma mansoni	nuclear receptor nhr-48	0.0041	0.014	0.014
Schistosoma mansoni	hypothetical protein	0.0107	0.0465	0.0465
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0053	0.0199	0.6299
Schistosoma mansoni	hypothetical protein	0.0031	0.0094	0.0094
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0024	0.0056	0.0533
Schistosoma mansoni	ap endonuclease	0.0019	0.0032	0.0032
Echinococcus multilocularis	FTZ F1 alpha	0.0086	0.0363	0.0363
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0056	0.0533
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0143	0.0143
Trypanosoma brucei	polo-like protein kinase	0.019	0.0872	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.018	0.0824	0.3156
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0086	0.0363	0.139
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0185	0.5779
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0024	0.0059	0.0323
Brugia malayi	nuclear receptor RXR	0.0046	0.0164	0.0628
Brugia malayi	steroid hormone receptor	0.0086	0.0363	0.139
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0034	0.0034
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0041	0.014	0.1175
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0037	0.0123	0.0123
Brugia malayi	nuclear receptor NHR-67	0.0041	0.014	0.0536
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0276	0.3081
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.0004	0.0014
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0021	0.0043	0.0043
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0078	0.03
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0034	0.0027
Schistosoma mansoni	hypothetical protein	0.0031	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0299	0.1404	0.5381
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0086	0.0363	0.139
Brugia malayi	nuclear receptor NHR-88	0.0041	0.014	0.0536
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0041	0.014	0.0536
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0074	0.0738
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0041	0.014	0.014
Trichomonas vaginalis	CAMK family protein kinase	0.019	0.0872	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0034	0.0027
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0143	0.0548
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0053	0.0199	0.6248
Echinococcus granulosus	thyroid hormone receptor alpha	0.0041	0.014	0.014
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0086	0.0363	0.139
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0315	0.0315
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0041	0.014	0.0536
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0102	0.0389
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0287	0.1098
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0043	0.0374
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0027	0.0194
Brugia malayi	Nuclear hormone receptor-like 1	0.0086	0.0363	0.139
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0024	0.0059	0.0323
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0071	0.0287	0.9513
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0209	0.0802
Echinococcus granulosus	transcription factor eb	0.0213	0.0983	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Echinococcus granulosus	caspase 2	0.003	0.009	0.009
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0287	1
Brugia malayi	hypothetical protein	0.0041	0.014	0.0536
Onchocerca volvulus		0.0058	0.0226	0.221
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0199	0.0764
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0041	0.014	0.014
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0027	0.0194
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0143	0.0143
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.0004	0.0004
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.019	0.0872	0.3342
Echinococcus granulosus	apoptotic protease activating factor 1	0.003	0.009	0.009
Brugia malayi	nuclear hormone receptor	0.0086	0.0363	0.139
Onchocerca volvulus	Protein ultraspiracle homolog	0.0086	0.0363	0.386
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0043	0.0124
Echinococcus multilocularis	adam	0.0026	0.0066	0.0066
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0034	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0086	0.0363	0.139
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0146	0.1573
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0086	0.0363	0.0363
Trypanosoma cruzi	polo-like protein kinase, putative	0.019	0.0872	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0376	0.1441
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.03	0.03
Brugia malayi	nuclear hormone receptor family member odr-7	0.0041	0.014	0.0536
Onchocerca volvulus		0.003	0.009	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Schistosoma mansoni	cpg binding protein	0.003	0.0086	0.0086
Onchocerca volvulus	Cell death protein 3 homolog	0.003	0.009	0.0566
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0086	0.0363	0.0363
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0098	0.0781
Brugia malayi	conserved hypotetical protein	0.0041	0.014	0.0536
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0098	0.0781
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0041	0.014	0.0536
Echinococcus multilocularis	expressed protein	0.0033	0.0102	0.0102
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0032	0.5
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0056	0.0214	0.0822
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.018	0.0824	0.0824
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0024	0.0056	0.0287
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.014	0.014
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0098	0.0781
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0094	0.0359
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0146	0.0146
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0143	0.1539
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0271	0.1037
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0097	0.0415	0.449
Echinococcus multilocularis	nuclear receptor nhr 48	0.0041	0.014	0.014
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0043	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0086	0.0363	0.139
Echinococcus granulosus	chromobox protein 1	0.0068	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Trichomonas vaginalis	CAMK family protein kinase	0.019	0.0872	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.0013	0.0026
Schistosoma mansoni	RAR-like nuclear receptor	0.0086	0.0363	0.0363
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.0423	0.1622
Trichomonas vaginalis	CAMK family protein kinase	0.019	0.0872	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.018	0.0824	0.3156
Schistosoma mansoni	hypothetical protein	0.0031	0.0094	0.0094
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0086	0.0363	0.0363
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0043	0.052
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0164	0.0628
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.03	1
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0056	0.0533
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0218	0.6957
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0078	0.03
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0071	0.0287	0.952
Brugia malayi	ecdysteroid receptor	0.0086	0.0363	0.139
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0043	0.0124
Echinococcus granulosus	GPCR family 2	0.0031	0.0094	0.0094
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0026	0.0066	0.0066
Onchocerca volvulus	Protein cycle homolog	0.0056	0.0214	0.2072
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Echinococcus granulosus	cpg binding protein	0.003	0.0086	0.0086
Schistosoma mansoni	caspase-7 (C14 family)	0.003	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0199	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0026
Brugia malayi	chromobox protein homolog 3	0.0038	0.0129	0.0493
Onchocerca volvulus		0.0041	0.014	0.1175
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0021	0.0043	0.0389
Echinococcus multilocularis	expressed conserved protein	0.009	0.0383	0.0383
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0232	0.0232
Brugia malayi	Nuclear hormone receptor E75	0.0041	0.014	0.0536
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0071	0.0287	0.952
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0056	0.0214	0.0214
Brugia malayi	angiogenesis inhibito	0.0027	0.0074	0.0285
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0315	0.1208
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.0136
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0021	0.0043	0.052
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0079	0.033	0.1263
Echinococcus multilocularis	transcription factor eb	0.0213	0.0983	0.0983
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0107	0.0465	0.0465
Schistosoma mansoni	single-minded	0.0024	0.0056	0.0056
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0086	0.0363	0.0363
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0056	0.0214	0.0822
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0043	0.052
Schistosoma mansoni	hypothetical protein	0.0067	0.0271	0.0271
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0021	0.0043	0.052
Leishmania major	protein kinase, putative	0.0024	0.0059	0.0323
Schistosoma mansoni	hypothetical protein	0.0031	0.0094	0.0094
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0021	0.0043	0.0389
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0032	0.0136
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0037	0.0123	0.0123
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0129	0.5783
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0213	0.0983	0.3765
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0021	0.0043	0.0389
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0024	0.0056	0.0533
Echinococcus multilocularis	caspase 2	0.003	0.009	0.009
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0315	0.1208
Brugia malayi	RNA binding protein	0.0076	0.0315	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0102	0.0389
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0098	0.2454
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0032	0.5
Brugia malayi	hypothetical protein	0.0026	0.0066	0.0252
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0021	0.0043	0.0389
Entamoeba histolytica	acyl-coA synthetase, putative	0.0071	0.0287	0.303
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Brugia malayi	Steroid receptor seven-up type 2	0.0086	0.0363	0.139
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0043	0.052
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0086	0.0363	0.139
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0209	0.0802
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0226	0.0866
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0071	0.0287	0.9513
Schistosoma mansoni	acetyl-CoA synthetase	0.0021	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0199	0.0764
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0094	0.0359
Schistosoma mansoni	ap endonuclease	0.0019	0.0032	0.0032
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0287	0.9513
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0287	0.9513
Onchocerca volvulus		0.0086	0.0363	0.386
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.018	0.0824	0.0824
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0086	0.0363	0.0363
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.03	0.03
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0098	0.0781
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0034	0.0027
Schistosoma mansoni	thyroid hormone receptor	0.0086	0.0363	0.0363
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0086	0.0363	0.0363
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0143	0.1539
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0043	0.0163
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.014	0.014
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0.0034	0.0219
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0412	0.4519
Trichomonas vaginalis	CAMK family protein kinase	0.019	0.0872	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0185	0.5779
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0025	0.0061	0.0061
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0164	0.0628
Echinococcus multilocularis	ecdysone induced protein 78C	0.0086	0.0363	0.0363
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0021	0.0043	0.0623
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0021	0.0043	0.052
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0041	0.014	0.014
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.0637	0.2443
Entamoeba histolytica	serine/threonine protein kinase, putative	0.019	0.0872	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.074	0.3563	0.3563
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0071	0.0287	0.9513
Brugia malayi	hypothetical protein	0.0046	0.0164	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0276	0.0276
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.018	0.0824	0.0824
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0046	0.0164	0.0164
Trichomonas vaginalis	CAMK family protein kinase	0.019	0.0872	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0185	0.5779
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0412	0.1578
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Brugia malayi	nuclear receptor RXR	0.0041	0.014	0.0536
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0287	0.9513
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0034	0.0034
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0034	0.0132
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0043	0.0163
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0024	0.0059	0.0323
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0021	0.0043	0.0623
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0034	0.0135
Echinococcus granulosus	expressed conserved protein	0.009	0.0383	0.0383
Loa Loa (eye worm)	hypothetical protein	0.003	0.009	0.0343
Schistosoma mansoni	zinc finger protein	0.0041	0.014	0.014
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0024	0.0059	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0094	0.0359
Brugia malayi	PAS domain containing protein	0.0024	0.0056	0.0215
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0024	0.0056	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0287	0.1098
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0089	0.0376	0.1441
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0102	0.1059
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0024	0.0056	0.0533
Brugia malayi	hypothetical protein	0.0041	0.014	0.0536
Echinococcus multilocularis	apoptotic protease activating factor 1	0.003	0.009	0.009
Echinococcus granulosus	muscleblind protein	0.0299	0.1404	0.1404
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.0618	0.0618
Loa Loa (eye worm)	oxidoreductase	0.0021	0.0043	0.0163
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0043	0.0124
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0325	0.1244
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0146	0.6804
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0032	0.0123
Loa Loa (eye worm)	hypothetical protein	0.003	0.009	0.0343
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0032	0.0253
Schistosoma mansoni	chromobox protein	0.0068	0.0276	0.0276
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0402	0.4545
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0032	0.0123
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0034	0.0034
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0041	0.014	0.014
Brugia malayi	nuclear hormone receptor	0.0041	0.014	0.0536
Echinococcus multilocularis	dnaJ subfamily B	0.04	0.1897	0.1897
Onchocerca volvulus		0.0071	0.0287	0.2942
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.03	1
Entamoeba histolytica	hypothetical protein	0.0107	0.0465	0.5158
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0146	0.1573
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Loa Loa (eye worm)	angiogenesis inhibito	0.0014	0.0009	0.0033
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0021	0.0043	0.0043
Loa Loa (eye worm)	acetyltransferase	0.0142	0.0637	0.2443
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0086	0.0363	0.139
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Onchocerca volvulus		0.0028	0.0078	0.0432
Schistosoma mansoni	coup transcription factor	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0086	0.0363	0.0363
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0043	0.052
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.03	1
Brugia malayi	MH2 domain containing protein	0.0144	0.0646	0.2476
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.018	0.0824	0.0824
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0129	0.1374
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0094	0.0094
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0021	0.0043	0.0124
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0086	0.0363	0.0363
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Schistosoma mansoni	hypothetical protein	0.0205	0.0942	0.0942
Brugia malayi	hypothetical protein	0.0107	0.0465	0.1784
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0164	0.0628
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0046	0.0164	0.0628
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0034	0.0034
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0021	0.0043	0.0389
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0287	0.303
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0043	0.0163
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.1338	0.1338
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0412	0.1578
Brugia malayi	hypothetical protein	0.003	0.009	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0056	0.0215
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0287	1
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0037	0.0123	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0086	0.0363	0.139
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0043	0.0163
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.03	0.03
Brugia malayi	CHE-14 protein	0.0041	0.0143	0.0548
Schistosoma mansoni	chromobox protein	0.0068	0.0276	0.0276
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0086	0.0363	0.139
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0027	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0078	0.03
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0024	0.0056	0.0287
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0013	0.0026
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.019	0.0872	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0199	0.0764
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0129	0.1151
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.018	0.0824	0.0824
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0086	0.0363	0.0363
Brugia malayi	tailless protein	0.0041	0.014	0.0536
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0143	0.1541
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0646	0.2476
Schistosoma mansoni	cpg binding protein	0.003	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0043	0.0163
Onchocerca volvulus	Papilin homolog	0.0028	0.0078	0.0432
Brugia malayi	serine/threonine-protein kinase plk-2	0.019	0.0872	0.3342
Schistosoma mansoni	hypothetical protein	0.003	0.009	0.009
Echinococcus granulosus	dnaJ subfamily B	0.04	0.1897	0.1897
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0027	0.0194
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0021	0.0043	0.052
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	0.0546	0.261	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0287	0.303
Schistosoma mansoni	aryl hydrocarbon receptor	0.0025	0.0061	0.0061
Schistosoma mansoni	retinoic acid receptor RXR	0.0086	0.0363	0.0363
Loa Loa (eye worm)	DR-78	0.0041	0.014	0.0536
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0043	0.0163
Brugia malayi	ADAMTS-like protease	0.0027	0.0074	0.0285
Brugia malayi	CHD4 protein	0.0013	0.0004	0.0014
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.014	0.014
Schistosoma mansoni	patched 1	0.0041	0.0143	0.0143
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0164	0.0628
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0212	0.0977	0.3745
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0024	0.0056	0.0533
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0107	0.0465	0.0465
Onchocerca volvulus		0.0078	0.0325	0.3399
Schistosoma mansoni	hypothetical protein	0.0205	0.0942	0.0942
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0041	0.014	0.0536
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.0637	0.0637
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0021	0.0043	0.0389
Echinococcus granulosus	fatty acid binding protein FABP2	0.0036	0.0118	0.0118
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0041	0.014	0.1175
Schistosoma mansoni	nuclear hormone receptor	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0299	0.1404	0.5381
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0043	0.0163
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0034	0.0027
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0021	0.0043	0.0389
Mycobacterium leprae	Possible regulatory protein	0.0024	0.0056	0.0562
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0043	0.0374
Plasmodium vivax	acyl-CoA synthetase, putative	0.0053	0.0199	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0074	0.0738
Entamoeba histolytica	heat shock transcription factor, putative	0.0097	0.0415	0.4559
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	0.0546	0.261	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0066	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0129	0.0493
Echinococcus granulosus	chromobox protein 1	0.0068	0.0276	0.0276
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0094	0.0359
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0021	0.0043	0.0389
Schistosoma mansoni	rotamase	0.0033	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.0136
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0021	0.0043	0.0163
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0041	0.014	0.014
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0086	0.0363	0.139
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0646	0.2476
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0086	0.0363	0.0363
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.0637	0.0637
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0027	0.0194
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0056	0.0533
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0086	0.0363	0.139
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0032	0.0032
Schistosoma mansoni	cpg binding protein	0.0028	0.0078	0.0078
Brugia malayi	hypothetical protein	0.0078	0.0325	0.1244
Entamoeba histolytica	heat shock transcription factor, putative	0.0097	0.0415	0.4559
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0086	0.0363	0.139
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0041	0.014	0.014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0086	0.0363	0.139
Brugia malayi	hypothetical protein	0.0055	0.0209	0.0802
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.03	0.3185
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.0136
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0041	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0363	0.139
Schistosoma mansoni	kinase	0.0097	0.0414	0.0414
Schistosoma mansoni	serine/threonine protein kinase	0.019	0.0872	0.0872
Entamoeba histolytica	heat shock transcription factor, putative	0.0097	0.0415	0.4559
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0977	0.3745
Loa Loa (eye worm)	nuclear hormone receptor	0.0041	0.014	0.0536
Schistosoma mansoni	transcription factor LCR-F1	0.0107	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0423	0.1622
Brugia malayi	ecdysone receptor	0.0041	0.014	0.0536
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0041	0.014	0.014
Echinococcus multilocularis	muscleblind protein 1	0.0299	0.1404	0.1404
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0172	0.0172
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0086	0.0363	0.139
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0199	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0415	0.159
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0079	0.033	0.033
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0086	0.0363	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0143	0.0548
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0086	0.0363	0.0363
Echinococcus multilocularis	protein patched	0.0041	0.0143	0.0143
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0034	0.0034
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0276	0.0276
Brugia malayi	Heterochromatin protein 1	0.0068	0.0276	0.1057
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0143	0.121
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0315	0.1208
Brugia malayi	TAR-binding protein	0.0076	0.0315	0.1208
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0034	0.0084
Brugia malayi	photoreceptor-specific nuclear receptor	0.0086	0.0363	0.139
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Onchocerca volvulus	Bile acid receptor homolog	0.0086	0.0363	0.386
Brugia malayi	hypothetical protein	0.0056	0.0214	0.0822
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0287	0.303
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0614	0.0614
Onchocerca volvulus	Serine\/threonine kinase homolog	0.019	0.0872	1
Entamoeba histolytica	hypothetical protein	0.0107	0.0465	0.5158
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0315	0.0315
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Loa Loa (eye worm)	steroid hormone receptor	0.0086	0.0363	0.139
Schistosoma mansoni	hypothetical protein	0.0058	0.0226	0.0226
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0086	0.0363	0.139
Leishmania major	protein kinase, putative	0.0024	0.0059	0.0323
Schistosoma mansoni	nuclear receptor	0.0041	0.014	0.014
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0086	0.0363	0.0363
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0036	0.0118	0.0118
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0086	0.0363	0.0363
Trichomonas vaginalis	CAMK family protein kinase	0.019	0.0872	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0041	0.014	0.0536
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0027	0.0194
Echinococcus granulosus	FTZ F1 alpha	0.0086	0.0363	0.0363
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0146	0.4251
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0021	0.0043	0.052
Onchocerca volvulus		0.0041	0.014	0.1175
Giardia lamblia	Kinase, PLK	0.019	0.0872	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0271	0.1037
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0287	0.303
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0004	0.0004
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.0423	0.1622
Echinococcus granulosus	aryl hydrocarbon receptor	0.0079	0.033	0.033
Trichomonas vaginalis	guanylate cyclase, putative	0.0024	0.0056	0.0533
Brugia malayi	Muscleblind-like protein	0.0299	0.1404	0.5381
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.1338	0.1338
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0097	0.0415	0.159
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0402	0.4545
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0036	0.0118	0.0118
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0276	0.3081
Echinococcus granulosus	fatty acid binding protein FABP2	0.0036	0.0118	0.0118
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0086	0.0363	0.139
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0086	0.0363	0.139
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0046	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0209	0.0802
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0043	0.0124
Echinococcus multilocularis	geminin	0.0205	0.0942	0.0942
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.018	0.0824	0.0824
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.0136
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0034	0.0034
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0034	0.0034
Echinococcus multilocularis	microtubule associated protein 2	0.2057	1	1
Trichomonas vaginalis	rotamase, putative	0.0032	0.0098	0.1015
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0094	0.0094
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.0423	0.1622
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0043	0.052
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.019	0.0872	1
Toxoplasma gondii	propionate-CoA ligase	0.0021	0.0043	0.0389
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0287	0.9513
Schistosoma mansoni	hypothetical protein	0.04	0.1897	0.1897
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0032	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0188	0.0722
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0226	0.0226
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.0164	0.0164
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.03	0.03
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0043	0.0124
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0086	0.0363	0.0363
Trichomonas vaginalis	adenylate cyclase, putative	0.0024	0.0056	0.0533
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0027	0.0194
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0071	0.0287	0.9513
Schistosoma mansoni	fatty acid binding protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0164	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0164	0.0628
Echinococcus granulosus	nuclear receptor nhr 48	0.0041	0.014	0.014
Schistosoma mansoni	nuclear receptor	0.0041	0.014	0.014
Trichomonas vaginalis	rotamase, putative	0.0033	0.0102	0.1059
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.0004	0.0004
Schistosoma mansoni	fatty acid binding protein	0.0036	0.0118	0.0118
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0046	0.0164	0.0164
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0287	0.303
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0287	0.1098
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0034	0.0027
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0034	0.0132
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0043	0.0389
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.0034	0.0135
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0021	0.0043	0.0389
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0098	0.0781
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0614	0.0614
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0021	0.0043	0.0389
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0129	0.1039
Echinococcus granulosus	expressed protein	0.0033	0.0102	0.0102
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0143	0.0143
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.019	0.0872	0.0872
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0032	0.0032
Trypanosoma cruzi	polo-like protein kinase, putative	0.019	0.0872	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0086	0.0086
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0021	0.0043	0.0124
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0287	0.1098
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0021	0.0043	0.052
Schistosoma mansoni	thyroid hormone receptor	0.0086	0.0363	0.0363
Echinococcus granulosus	ecdysone induced protein 78C	0.0086	0.0363	0.0363
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0412	0.0412
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0412	0.0412
Echinococcus multilocularis	muscleblind protein	0.0299	0.1404	0.1404
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0276	0.1057
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0287	0.1098
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0315	0.1208
Brugia malayi	Nuclear hormone receptor E75	0.0041	0.014	0.0536
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0021	0.0043	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Brugia malayi	Cell death protein 3 precursor	0.003	0.009	0.0343
Loa Loa (eye worm)	hypothetical protein	0.003	0.0088	0.0338
Schistosoma mansoni	microtubule-associated protein tau	0.2057	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0129	0.1374
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.018	0.0824	0.0824
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0043	0.0124
Onchocerca volvulus		0.003	0.0088	0.055
Entamoeba histolytica	hypothetical protein	0.0107	0.0465	0.5158
Brugia malayi	hypothetical protein	0.0046	0.0164	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0209	0.0802
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0129	0.1151
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0041	0.014	0.0536
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0146	0.4251
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0086	0.0363	0.139
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0034	0.0132
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0086	0.0363	0.0363
Trichomonas vaginalis	CAMK family protein kinase	0.019	0.0872	1
Plasmodium falciparum	acyl-CoA synthetase	0.0053	0.0199	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0024	0.0056	0.0533
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0043	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0286	0.1338	0.5125
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0043	0.0124
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0053	0.0199	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0086	0.0363	0.139
Brugia malayi	hypothetical protein	0.0286	0.1338	0.5125

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	25.9185 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	30.1313 uM	PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1497479

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1369359