Detailed information for compound 1382884

Basic information

Technical information
  • TDR Targets ID: 1382884
  • Name: 2-amino-4-(2-chlorophenyl)-6-(5-methylfuran-2 -yl)pyridine-3-carbonitrile
  • MW: 309.75 | Formula: C17H12ClN3O
  • H donors: 1 H acceptors: 2 LogP: 4.19 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(N)nc(cc1c1ccccc1Cl)c1ccc(o1)C
  • InChi: 1S/C17H12ClN3O/c1-10-6-7-16(22-10)15-8-12(13(9-19)17(20)21-15)11-4-2-3-5-14(11)18/h2-8H,1H3,(H2,20,21)
  • InChiKey: QUQSGBPPVGQVIP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-amino-4-(2-chlorophenyl)-6-(5-methyl-2-furyl)pyridine-3-carbonitrile
  • 2-amino-4-(2-chlorophenyl)-6-(5-methyl-2-furyl)-3-pyridinecarbonitrile
  • 2-amino-4-(2-chlorophenyl)-6-(5-methyl-2-furyl)nicotinonitrile
  • STOCK1S-67757
  • MLS000061767
  • SMR000070236

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Staphylococcus aureus (strain N315) Probable nicotinate-nucleotide adenylyltransferase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Treponema pallidum hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Babesia bovis cytidylyltransferase family protein Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Plasmodium berghei nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii Predicted nucleotidyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva hypothetical protein, conserved Get druggable targets OG5_131883 All targets in OG5_131883
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Entamoeba histolytica NMN adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 210 aa 23.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Plasmodium knowlesi cytoskeleton associated protein, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 170 aa 23.5 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 247 aa 20.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 21.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 153 aa 24.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 20.5 %
Trypanosoma brucei variant surface glycoprotein (VSG, atypical), putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 171 aa 20.5 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 205 aa 19.0 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Entamoeba histolytica nicotinamide nucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0398 0.0377
Trichomonas vaginalis set domain proteins, putative 0.0505 1 1
Leishmania major cathepsin L-like protease 0.0062 0.107 0.1603
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.1124 0.1132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0054
Echinococcus granulosus dnaJ subfamily B 0.0494 0.9779 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0155 0.0177
Loa Loa (eye worm) ctsf protein 0.0016 0.0155 0.0177
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0298 0.0253
Echinococcus multilocularis pyruvate kinase 0.004 0.0641 0.0636
Loa Loa (eye worm) pyruvate kinase 0.004 0.0641 0.0731
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0799 0.0911
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0762 0.076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0054
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0155 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0246 0.0147
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0092 0.0075
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0729 0.4065
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0729 0.0685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0749 0.421
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0298 0.1054
Brugia malayi Thioredoxin reductase 0.0046 0.0749 0.0855
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0749 0.0855
Chlamydia trachomatis pyruvate kinase 0.004 0.0641 1
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.6771 1
Plasmodium falciparum LCCL domain-containing protein 0.0048 0.0788 0.0967
Leishmania major phosphoinositide phosphatase 0.0302 0.5904 1
Onchocerca volvulus 0.0016 0.0155 0.0108
Brugia malayi CXXC zinc finger family protein 0.0035 0.0528 0.0602
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0148 0.0101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.1124 0.8429
Leishmania major hypothetical protein, unknown function 0.0087 0.1576 0.2482
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0063 0.0072
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0398 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0298 0.0286
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0155 0.0139
Leishmania major cathepsin L-like protease 0.0062 0.107 0.1603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.1124 0.1132
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0047 0.0054
Loa Loa (eye worm) fibroinase 0.0016 0.0155 0.0177
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0788 0.0788
Echinococcus multilocularis RUN 0.0048 0.0788 0.0788
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0395 0.0505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0155 0.0108
Echinococcus granulosus dna polymerase kappa 0.0023 0.0298 0.0286
Entamoeba histolytica hypothetical protein 0.0028 0.0398 0.0509
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0209 0.4041 0.4121
Mycobacterium ulcerans pyruvate kinase 0.004 0.0641 0.0744
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0155 0.001
Echinococcus granulosus pyruvate kinase 0.0021 0.0246 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0148 0.0132
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1306 0.2012
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0298 0.034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2162 0.3042
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2162 0.2769
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0641 0.0731
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0298 0.0286
Loa Loa (eye worm) hypothetical protein 0.01 0.1852 0.2112
Schistosoma mansoni cpg binding protein 0.0037 0.0567 0.0561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0451
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0246 0.0843
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1306 1
Brugia malayi Pre-SET motif family protein 0.0064 0.1124 0.1282
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.1062 0.1068
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1928 0.2688
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.1124 0.1132
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.107 0.6458
Entamoeba histolytica cysteine protease, putative 0.0016 0.0155 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0729 0.0855
Loa Loa (eye worm) pyruvate kinase 0.004 0.0641 0.0731
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0398 0.2158
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0398 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Echinococcus granulosus cpg binding protein 0.0037 0.0567 0.0561
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0047 0.0028
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0136 0.0155
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2162 0.3042
Echinococcus multilocularis Polycystic kidney disease protein 0.0048 0.0788 0.0788
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0641 0.0744
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0398 0.0377
Schistosoma mansoni hypothetical protein 0.0048 0.0788 0.0788
Toxoplasma gondii thioredoxin reductase 0.0046 0.0749 0.5192
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0155 0.0177
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1852 0.1877
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3302 0.4763
Schistosoma mansoni rab6-interacting 0.0048 0.0788 0.0788
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1306 0.1318
Trypanosoma cruzi tyrosine phosphatase, putative 0.0087 0.1576 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.0749 0.0908
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0729 0.0727
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0298 0.1632
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6939 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0641 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Loa Loa (eye worm) hypothetical protein 0.0048 0.0788 0.0899
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0155 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0762 0.076
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0298 0.034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1306 0.1749
Echinococcus multilocularis GPCR, family 2 0.0015 0.0136 0.0119
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.6771 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0153 0.0053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0298 0.0286
Entamoeba histolytica phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative 0.0087 0.1576 0.2219
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0641 0.0596
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0298 0.0286
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0136 0.0119
Schistosoma mansoni pyruvate kinase 0.004 0.0641 0.0636
Trypanosoma brucei pyruvate kinase 1 0.004 0.0641 0.534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Echinococcus multilocularis dna polymerase eta 0.0023 0.0298 0.0286
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0155 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0749 0.0908
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6939 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.107 0.6458
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0019 0.0022
Onchocerca volvulus 0.0016 0.0155 0.0108
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0729 0.1009
Leishmania major cathepsin L-like protease 0.0016 0.0155 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Echinococcus granulosus cathepsin l1 0.0011 0.0047 0.0028
Loa Loa (eye worm) hypothetical protein 0.0064 0.1124 0.1282
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0298 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.1124 0.1132
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0729 0.4065
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0119
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1852 0.1877
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0298 0.0227
Loa Loa (eye worm) hypothetical protein 0.0015 0.0136 0.0155
Loa Loa (eye worm) glutathione reductase 0.0046 0.0749 0.0855
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0298 0.1632
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1306 0.1318
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0155 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Schistosoma mansoni hypothetical protein 0.0033 0.0492 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0298 0.1632
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0641 0.0596
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0155 0.0108
Onchocerca volvulus 0.01 0.1852 0.1813
Toxoplasma gondii cathepsin CPL 0.0016 0.0155 0.006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.8767 1
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0155 0.0156
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0075 0.0085
Onchocerca volvulus 0.0048 0.0788 0.0745
Plasmodium vivax SET domain protein, putative 0.0064 0.1124 0.1474
Leishmania major cathepsin L-like protease 0.0016 0.0155 0.0012
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0729 0.0727
Schistosoma mansoni lipoxygenase 0.0209 0.4041 0.4121
Brugia malayi Smad1 0.0009 0.0019 0.0022
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0398 0.0377
Leishmania major cathepsin L-like protease 0.0062 0.107 0.1603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0153 0.0053
Echinococcus granulosus pyruvate kinase 0.004 0.0641 0.0636
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.6939 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.6771 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.1124 0.1132
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0398 0.5074
Brugia malayi Cathepsin L-like precursor 0.0016 0.0155 0.0177
Leishmania major pyruvate kinase 0.004 0.0641 0.0856
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1928 0.2688
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0298 0.1054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0799 0.0911
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.005 0.0031
Echinococcus granulosus pyruvate kinase 0.0021 0.0246 0.0232
Plasmodium falciparum glutathione reductase 0.0046 0.0749 0.0908
Echinococcus granulosus GPCR family 2 0.0015 0.0136 0.0119
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.1124 0.1132
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0395 0.0451
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0155 0.0139
Trypanosoma brucei unspecified product 0.0023 0.0298 0.1632
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1306 0.1318
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0398 0.2158
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0641 0.3449
Loa Loa (eye worm) hypothetical protein 0.0048 0.0788 0.0899
Onchocerca volvulus 0.0016 0.0155 0.0108
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0136 0.0119
Echinococcus multilocularis cysteine protease 0.0016 0.0155 0.0139
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0298 0.0253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0729 0.0685
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0136 0.0155
Schistosoma mansoni rab6-interacting 0.0048 0.0788 0.0788
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1306 0.1318
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0398 0.0434
Brugia malayi hypothetical protein 0.0048 0.0788 0.0899
Plasmodium vivax vivapain-2 0.0016 0.0155 0.001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0298 0.0365
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0729 0.0727
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.1124 0.1132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.1358 0.1371
Loa Loa (eye worm) hypothetical protein 0.004 0.0641 0.0731
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0298 0.1054
Trypanosoma brucei unspecified product 0.0016 0.0153 0.0053
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0298 0.1632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1928 0.2401
Echinococcus multilocularis pyruvate kinase 0.0032 0.047 0.0461
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0963 0.5704
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.2624 0.2993
Brugia malayi Cathepsin L-like precursor 0.0016 0.0155 0.0177
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.2624 0.2993
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Brugia malayi MH1 domain containing protein 0.0009 0.0019 0.0022
Echinococcus multilocularis pyruvate kinase 0.0021 0.0246 0.0232
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0298 0.0227
Schistosoma mansoni pyruvate kinase 0.0021 0.0246 0.0232
Plasmodium vivax pyruvate kinase, putative 0.004 0.0641 0.0744
Brugia malayi glutathione reductase 0.0046 0.0749 0.0855
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.6771 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0492 0.0561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Loa Loa (eye worm) doublecortin family protein 0.0048 0.0788 0.0899
Loa Loa (eye worm) cysteine protease 0.0016 0.0155 0.0177
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0398 0.0368
Schistosoma mansoni lipoxygenase 0.0123 0.2314 0.2351
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1928 0.2688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Giardia lamblia Pyruvate kinase 0.0021 0.0246 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.5904 0.5884
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0155 0.0139
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0788 0.0788
Loa Loa (eye worm) pyruvate kinase 0.004 0.0641 0.0731
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.005 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0799 0.0911
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.6771 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0155 0.0177
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0749 0.0908
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.9779 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0298 0.1054
Brugia malayi Cathepsin L-like precursor 0.0016 0.0155 0.0177
Brugia malayi Pre-SET motif family protein 0.0444 0.8767 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0729 0.0727
Brugia malayi Cathepsin L-like precursor 0.0016 0.0155 0.0177
Echinococcus granulosus RUN 0.0048 0.0788 0.0788
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0155 0.0012
Echinococcus multilocularis pyruvate kinase 0.0021 0.0246 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1928 0.2688
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0641 0.0731
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0641 0.0596
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1306 0.1749
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0729 0.0727
Leishmania major pyruvate kinase 0.004 0.0641 0.0856
Leishmania major DNA polymerase kappa, putative 0.0023 0.0298 0.0262
Brugia malayi MH2 domain containing protein 0.0139 0.2624 0.2993
Loa Loa (eye worm) hypothetical protein 0.0016 0.0155 0.0177
Onchocerca volvulus 0.0016 0.0155 0.0108
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0729 0.0727
Schistosoma mansoni polycystin 1-related 0.0048 0.0788 0.0788
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0148 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0298 0.1054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3302 0.4763
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0298 0.0227
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0063 0.0072
Trypanosoma brucei unspecified product 0.0016 0.0153 0.0053
Echinococcus multilocularis cysteine protease 0.0016 0.0155 0.0139
Loa Loa (eye worm) Smad1 0.0009 0.0019 0.0022
Brugia malayi Cathepsin L-like precursor 0.0011 0.0047 0.0054
Schistosoma mansoni DNA polymerase eta 0.0023 0.0298 0.0286
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0155 0.0156
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0155 0.001
Onchocerca volvulus 0.0035 0.0528 0.0483
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) 0.0302 0.5904 0.8691
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0788 0.0788
Onchocerca volvulus 0.0016 0.0155 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.005 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Schistosoma mansoni cpg binding protein 0.0035 0.0528 0.0521
Loa Loa (eye worm) hypothetical protein 0.0048 0.0799 0.0911
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0729 0.0831
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.107 0.6458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Leishmania major DNA polymerase eta, putative 0.0023 0.0298 0.0262
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0729 0.6295
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0155 0.0108
Plasmodium falciparum pyruvate kinase 0.004 0.0641 0.0744
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0641 0.534
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0398 0.0377
Brugia malayi Doublecortin family protein 0.0048 0.0788 0.0899
Onchocerca volvulus 0.0016 0.0155 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0641 0.0596
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1852 0.2112
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0641 0.0381
Plasmodium vivax vivapain-2 0.0016 0.0155 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Entamoeba histolytica hypothetical protein, conserved 0.0087 0.1576 0.2219
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0019 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Giardia lamblia DINP protein human, muc B family 0.0023 0.0298 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0209 0.4041 0.4121
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1306 0.1749
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0092 0.0105
Brugia malayi Cathepsin L-like precursor 0.0016 0.0155 0.0177
Echinococcus granulosus dna polymerase eta 0.0023 0.0298 0.0286
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3302 0.4557
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0045 0.0729 0.0831
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0148 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.107 0.6458
Schistosoma mansoni hypothetical protein 0.0494 0.9779 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.034
Leishmania major cathepsin L-like protease 0.0016 0.0155 0.0012
Mycobacterium tuberculosis Probable reductase 0.0104 0.1928 0.2688
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0246 0.0147
Brugia malayi cathepsin L-like precursor 0.0011 0.0047 0.0054
Echinococcus granulosus cathepsin l1 0.0016 0.0155 0.0139
Echinococcus granulosus pyruvate kinase 0.0021 0.0246 0.0232
Echinococcus multilocularis cpg binding protein 0.0037 0.0567 0.0561
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.12 0.9081
Schistosoma mansoni loxhd1 0.0048 0.0788 0.0788
Schistosoma mansoni cpg binding protein 0.0037 0.0567 0.0561
Onchocerca volvulus 0.0016 0.0155 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0136 0.0119
Brugia malayi hypothetical protein 0.0048 0.0788 0.0899
Leishmania major cathepsin L-like protease 0.0016 0.0155 0.0012
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1928 0.2688
Plasmodium vivax glutathione reductase, putative 0.0046 0.0749 0.0908
Brugia malayi MH1 domain containing protein 0.0009 0.0019 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0528 0.0602
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0298 0.0286
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0155 0.0177
Echinococcus multilocularis pyruvate kinase 0.004 0.0641 0.0636
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0298 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0155 0.0108
Brugia malayi MH2 domain containing protein 0.0009 0.0019 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0136 0.0155
Echinococcus granulosus pyruvate kinase 0.004 0.0641 0.0636
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0641 0.4253
Schistosoma mansoni pyruvate kinase 0.004 0.0641 0.0636
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0298 0.034
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0155 0.0139
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0729 0.0685
Giardia lamblia Pyruvate kinase 0.004 0.0641 0.0725
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0155 0.0049
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0729 0.0727
Onchocerca volvulus 0.0048 0.0788 0.0745
Trypanosoma brucei trypanothione reductase 0.0046 0.0749 0.6518
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.6939 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0805 0.4598
Onchocerca volvulus 0.0064 0.1124 0.1082
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0788 0.0788
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0089 0.0102
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0641 0.3449
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0155 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0153 0.0053
Leishmania major cathepsin L-like protease 0.0016 0.0155 0.0012
Treponema pallidum hypothetical protein 0.0345 0.6771 0.9752
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0054
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0148 0.0169
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0729 0.0727
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0148 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0398 0.2709
Brugia malayi Cathepsin L-like precursor 0.0011 0.0047 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6939 0.6924
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0136 0.0119
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpB 0.0302 0.5904 0.8691
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0298 0.1632
Echinococcus multilocularis pyruvate kinase 0.0021 0.0246 0.0232
Echinococcus granulosus Polycystic kidney disease protein 0.0048 0.0788 0.0788
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2162 0.3042
Plasmodium vivax multidomain scavenger receptor, putative 0.0048 0.0788 0.0967
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1852 0.1877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.107 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0155 0.0108
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0155 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0155 0.0108
Brugia malayi MH2 domain containing protein 0.0009 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0492 0.0561
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1306 0.1749
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0092 0.0075
Leishmania major trypanothione reductase 0.0046 0.0749 0.1045
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0119
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0119
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0729 0.0989

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 5.05 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 7.76 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.2841 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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