Detailed information for compound 1384459

Basic information

Technical information
  • TDR Targets ID: 1384459
  • Name: ZINC02621038
  • MW: 352.24 | Formula: C16H8F4N2O3
  • H donors: 2 H acceptors: 2 LogP: 4.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc2ccccc2oc1=O)NNc1c(F)c(F)cc(c1F)F
  • InChi: 1S/C16H8F4N2O3/c17-9-6-10(18)13(20)14(12(9)19)21-22-15(23)8-5-7-3-1-2-4-11(7)25-16(8)24/h1-6,21H,(H,22,23)
  • InChiKey: CTZLNCYTURINNK-UHFFFAOYSA-N  


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Synonyms

  • MLS000772549
  • SMR000377184
  • T5274150

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi regulator of G-protein signaling rgs-7 0.0236 0.1495 0.1495
Echinococcus multilocularis tyrosine protein kinase Src64B 0.003 0.0061 0.0073
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0064 0.0297 0.0355
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Echinococcus granulosus muscleblind protein 0.018 0.1107 0.1325
Onchocerca volvulus Tyrosine kinase homolog 0.003 0.0061 0.0235
Entamoeba histolytica protein kinase, putative 0.0028 0.0043 0.0287
Onchocerca volvulus 0.003 0.0061 0.0235
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0049 0.1641
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0049 0.5
Echinococcus multilocularis muscleblind protein 1 0.018 0.1107 0.1325
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0369 0.2466
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0049 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0369 0.2466
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.0061 0.0073
Echinococcus granulosus tyrosine protein kinase Src42A 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0236 0.1495 0.1495
Echinococcus multilocularis tyrosine protein kinase shark 0.003 0.0061 0.0073
Echinococcus granulosus c src tyrosine kinase 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0049 0.5
Entamoeba histolytica p21-activated kinase 0.0028 0.0043 0.0287
Echinococcus granulosus G protein coupled receptor kinase 1 0.088 0.5985 0.7164
Schistosoma mansoni vesicular amine transporter 0.0118 0.0669 0.0669
Loa Loa (eye worm) hypothetical protein 0.0062 0.0285 0.0285
Echinococcus multilocularis regulator of G protein signaling 7 0.0236 0.1495 0.1789
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0064 0.0297 1
Echinococcus multilocularis Immunoglobulin 0.0115 0.0652 0.0781
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.122 0.8355 0.8355
Echinococcus granulosus tyrosine protein kinase 0.003 0.0061 0.0073
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Echinococcus granulosus regulator of G protein signaling 3 0.0236 0.1495 0.1789
Echinococcus granulosus twitchin 0.0121 0.0695 0.0832
Entamoeba histolytica hypothetical protein 0.0074 0.0369 0.2466
Loa Loa (eye worm) hypothetical protein 0.0394 0.2596 0.2596
Onchocerca volvulus 0.003 0.0061 0.0235
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.003 0.0061 0.0073
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.0061 0.2052
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Brugia malayi CHE-14 protein 0.0051 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0119 0.0678 0.0678
Brugia malayi SH2 domain containing protein 0.003 0.0061 0.0061
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0028 0.0043 0.1446
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0236 0.1495 0.1495
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0297 0.1985
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.01 0.01
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/ACK protein kinase 0.003 0.0061 0.0061
Plasmodium vivax protein kinase, putative 0.003 0.0061 0.2052
Echinococcus multilocularis ephrin type A receptor 4 A 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Brugia malayi Muscleblind-like protein 0.018 0.1107 0.1107
Brugia malayi PXA domain containing protein 0.0236 0.1495 0.1495
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0049 0.5
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Echinococcus multilocularis axis inhibition protein axin 0.0236 0.1495 0.1789
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Echinococcus multilocularis tyrosine protein kinase Blk 0.003 0.0061 0.0073
Brugia malayi PXA domain containing protein 0.0236 0.1495 0.1495
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0049 0.5
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0043 0.1446
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0061 0.0073
Brugia malayi serine/threonine protein kinase 6 0.0064 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni cell adhesion molecule 0.0115 0.0652 0.0652
Echinococcus granulosus expressed protein 0.0236 0.1495 0.1789
Echinococcus granulosus regulator of G protein signaling 7 0.0236 0.1495 0.1789
Loa Loa (eye worm) TK/RYK protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Blk 0.003 0.0061 0.0073
Trypanosoma brucei protein kinase, putative 0.0037 0.0104 0.3498
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0028 0.0043 0.1446
Leishmania major protein kinase, putative 0.0064 0.0297 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0049 0.5
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Plasmodium falciparum calcium-dependent protein kinase 7 0.0028 0.0043 0.1446
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0074 0.0369 0.2466
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0028 0.0043 0.1446
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0297 0.1985
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Echinococcus multilocularis tyrosine protein kinase Src42A 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0236 0.1495 0.1495
Loa Loa (eye worm) TK/EPH protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0049
Loa Loa (eye worm) sema domain-containing protein 0.017 0.1035 0.1035
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus multilocularis regulator of G protein signaling 3 0.0236 0.1495 0.1789
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Echinococcus granulosus defective proboscis extension response 0.0115 0.0652 0.0781
Echinococcus granulosus insulin growth factor 1 receptor beta 0.003 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0407
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0064 0.0297 0.1985
Echinococcus granulosus integrin linked protein kinase 0.003 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0297 0.1985
Schistosoma mansoni protein tyrosine kinase 0.003 0.0061 0.0061
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0028 0.0043 0.1446
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Onchocerca volvulus 0.003 0.0061 0.0235
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.01 0.01
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0061 0.0073
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0043 0.0287
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.122 0.8355 0.8355
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0061 0.0073
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trichomonas vaginalis protein tyrosine kinase, putative 0.003 0.0061 0.0407
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.017 0.1035 0.1035
Echinococcus multilocularis protein kinase 0.003 0.0061 0.0073
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Brugia malayi hypothetical protein 0.0236 0.1495 0.1495
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0236 0.1495 0.1495
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Entamoeba histolytica tyrosin kinase, putative 0.0105 0.058 0.3883
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.003 0.0061 0.0073
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0043 0.0043
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0049 0.0326
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0061 0.0407
Echinococcus multilocularis transfer RNA-Thr 0.003 0.0061 0.0073
Leishmania major protein kinase, putative 0.003 0.0061 0.2052
Echinococcus multilocularis expressed conserved protein 0.0112 0.0628 0.0752
Loa Loa (eye worm) hypothetical protein 0.018 0.1107 0.1107
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.0061 0.0073
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Trypanosoma brucei aurora B kinase 0.0064 0.0297 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Echinococcus multilocularis insulin receptor 0.003 0.0061 0.0073
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0061 0.0073
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0678 0.0812
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0049 0.5
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0064 0.0297 0.1985
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0061 0.0073
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.003 0.0061 0.0073
Brugia malayi Probable exocyst complex component Sec5 0.0074 0.0369 0.0369
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6678 0.7994
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.003 0.0061 0.0073
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0691 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.1495 1
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Echinococcus granulosus tyrosine kinase 0.003 0.0061 0.0073
Echinococcus multilocularis tyrosine kinase 0.003 0.0061 0.0073
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0061 0.0073
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.0652 0.0652
Entamoeba histolytica protein kinase, putative 0.0064 0.0297 0.1985
Brugia malayi hypothetical protein 0.003 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0236 0.1495 1
Echinococcus granulosus tyrosine kinase 0.003 0.0061 0.0073
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0061 0.0073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Brugia malayi Regulator of G protein signaling domain containing protein 0.0236 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Onchocerca volvulus 0.003 0.0061 0.0235
Toxoplasma gondii aurora kinase 0.0064 0.0297 1
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Echinococcus multilocularis raf serine:threonine protein kinase 0.003 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Entamoeba histolytica cell surface protease gp63, putative 0.0074 0.0369 0.2466
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Leishmania major serine/threonine-protein kinase a, putative 0.0028 0.0043 0.1446
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.1495 1
Leishmania major hypothetical protein, conserved 0.003 0.0061 0.2052
Schistosoma mansoni plexin 0.0224 0.141 0.141
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.0061 0.2052
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0028 0.0043 0.0287
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0061 0.0061
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0028 0.0043 0.1446
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Echinococcus multilocularis Immunoglobulin 0.0115 0.0652 0.0781
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Echinococcus granulosus neuroglian 0.0115 0.0652 0.0781
Brugia malayi C-terminal src kinase protein 1 0.003 0.0061 0.0061
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus exocyst complex component 2 0.0074 0.0369 0.0441
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0049 0.0049
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.0061 0.0073
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0061 0.0073
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.003 0.0061 0.2052
Leishmania major protein kinase, putative 0.0028 0.0043 0.1446
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.003 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Onchocerca volvulus 0.003 0.0061 0.0235
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0369 0.2466
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Echinococcus granulosus axis inhibition protein axin 0.0236 0.1495 0.1789
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0028 0.0043 0.1446
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.0061 0.0073
Entamoeba histolytica hypothetical protein 0.0236 0.1495 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0297 0.1985
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0146 0.0864 0.0864
Echinococcus multilocularis regulator of G protein signaling 7 0.0236 0.1495 0.1789
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0369 0.2466
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/INSR protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Entamoeba histolytica hypothetical protein 0.0074 0.0369 0.2466
Entamoeba histolytica hypothetical protein 0.0028 0.0043 0.0287
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0236 0.1495 0.1789
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Echinococcus granulosus tyrosine protein kinase pr2 0.003 0.0061 0.0073
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.01 0.0119
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.003 0.0061 0.0407
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0037 0.0104 0.0124
Echinococcus granulosus semaphorin 1A 0.017 0.1035 0.1239
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0104 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.1495 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0407
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0678 0.0678
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0028 0.0043 0.1446
Brugia malayi hypothetical protein 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fps85D 0.003 0.0061 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0205 0.1371
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trypanosoma cruzi aurora B kinase, putative 0.0064 0.0297 1
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0236 0.1495 1
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica ankyrin repeat protein 0.003 0.0061 0.0407
Echinococcus granulosus raf serine:threonine protein kinase 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0236 0.1495 0.1495
Schistosoma mansoni regulator of G protein signaling 0.0236 0.1495 0.1495
Trypanosoma cruzi protein kinase, putative 0.003 0.0061 0.2052
Brugia malayi Sema domain containing protein 0.017 0.1035 0.1035
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0064 0.0297 0.1985
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0115 0.0652 0.0652
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) AUR protein kinase 0.0064 0.0297 0.0297
Loa Loa (eye worm) plexin A 0.0468 0.3115 0.3115
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0297 0.0297
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Schistosoma mansoni hypothetical protein 0.0049 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0236 0.1495 0.1495
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0236 0.1495 1
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0061 0.0073
Plasmodium falciparum protein kinase, putative 0.003 0.0061 0.2052
Echinococcus granulosus fibroblast growth factor receptor 4 0.003 0.0061 0.0073
Brugia malayi DNA-binding protein LAG-1 0.0074 0.0369 0.0369
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Echinococcus multilocularis aurora kinase A 0.0064 0.0297 0.0355
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.0061 0.0061
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.003 0.0061 0.0235
Echinococcus multilocularis semaphorin 5B 0.017 0.1035 0.1239
Echinococcus granulosus Regulator of G protein signaling 20 0.0236 0.1495 0.1789
Onchocerca volvulus 0.003 0.0061 0.0235
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus multilocularis FL cytokine receptor 0.003 0.0061 0.0073
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1034 0.1238
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0123 0.0123
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.0061 0.2052
Schistosoma mansoni protein kinase 0.0037 0.0104 0.0104
Onchocerca volvulus 0.0394 0.2596 1
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Brugia malayi Regulator of G protein signaling domain containing protein 0.0236 0.1495 0.1495
Echinococcus granulosus expressed conserved protein 0.0112 0.0628 0.0752
Brugia malayi IPT/TIG domain containing protein 0.0074 0.0369 0.0369
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Entamoeba histolytica SH2-protein kinase domain containing protein 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) hypothetical protein 0.017 0.1035 0.1035
Echinococcus multilocularis neuroglian 0.0115 0.0652 0.0781
Trichomonas vaginalis STE family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Echinococcus granulosus protein kinase 0.003 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Brugia malayi regulator of G-protein signaling egl-10 0.0236 0.1495 0.1495
Schistosoma mansoni tyrosine protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus beta-adrenergic receptor kinase 0.1116 0.763 0.9133
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.003 0.0061 0.0073
Schistosoma mansoni protein kinase 0.0037 0.0104 0.0104
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0061 0.0073
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0061 0.0073
Entamoeba histolytica protein kinase, putative 0.0028 0.0043 0.0287
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0049 0.5
Loa Loa (eye worm) AGC/AKT protein kinase 0.0028 0.0043 0.0043
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0074 0.0369 0.2466
Schistosoma mansoni serine/threonine RGC 0.003 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Brugia malayi plexin A 0.0468 0.3115 0.3115
Schistosoma mansoni axis inhibition protein axin 0.0236 0.1495 0.1495
Schistosoma mansoni nephrin 0.0115 0.0652 0.0652
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.003 0.0061 0.0073
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0064 0.0297 0.0355
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0236 0.1495 0.1495
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/EGFR protein kinase 0.003 0.0061 0.0061
Echinococcus multilocularis beta adrenergic receptor kinase 0.1116 0.763 0.9133
Loa Loa (eye worm) TK/ALK protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0224 0.141 0.141
Schistosoma mansoni regulator of G protein signaling 0.0236 0.1495 0.1495
Loa Loa (eye worm) TK/FAK protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) RGS-3 protein 0.0236 0.1495 0.1495
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus multilocularis transcription factor collier 0.0074 0.0369 0.0441
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1034 0.1238
Loa Loa (eye worm) AUR protein kinase 0.0064 0.0297 0.0297
Schistosoma mansoni src-type protein tyrosine kinase-related 0.003 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.017 0.1035 0.1035
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0236 0.1495 0.1495
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.0061 0.0073
Trypanosoma cruzi NIMA-related kinase, putative 0.0028 0.0043 0.1446
Brugia malayi bone morphogenetic protein type 1 receptor 0.003 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.1116 0.763 0.763
Loa Loa (eye worm) hypothetical protein 0.018 0.1107 0.1107
Schistosoma mansoni hypothetical protein 0.0224 0.141 0.141
Brugia malayi serine/threonine kinase 12 0.0064 0.0297 0.0297
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0205 0.0245
Echinococcus multilocularis Regulator of G protein signaling 20 0.0236 0.1495 0.1789
Brugia malayi Guanylyl cyclase protein 23 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Echinococcus granulosus tyrosine protein kinase Lyn 0.0037 0.0104 0.0124
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Echinococcus multilocularis fibroblast growth factor receptor 4 0.003 0.0061 0.0073
Entamoeba histolytica tyrosin kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.0061 0.0073
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.1495 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni semaphorin 5-related 0.017 0.1035 0.1035
Schistosoma mansoni axis inhibition protein axin 0.0236 0.1495 0.1495
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0061 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Loa Loa (eye worm) AUR protein kinase 0.0064 0.0297 0.0297
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0049 0.0049
Echinococcus multilocularis tyrosine protein kinase pr2 0.003 0.0061 0.0073
Schistosoma mansoni hypothetical protein 0.0074 0.0369 0.0369
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0678 0.0812
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Loa Loa (eye worm) hypothetical protein 0.017 0.1035 0.1035
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0061 0.0407
Trypanosoma brucei Pseudokinase, putative 0.003 0.0061 0.2052
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase ABL1 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0074 0.0369 0.2466
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0043 0.0287
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0049 0.5
Onchocerca volvulus 0.003 0.0061 0.0235
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni hypothetical protein 0.0049 0.0192 0.0192
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Giardia lamblia Aurora kinase 0.0064 0.0297 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0407
Brugia malayi Fibronectin type III domain containing protein 0.0115 0.0652 0.0652
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.0061 0.2052
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.003 0.0061 0.0073
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase, putative 0.0028 0.0043 0.0287
Echinococcus multilocularis G protein coupled receptor kinase 6 0.122 0.8355 1
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Entamoeba histolytica protein kinase, putative 0.0028 0.0043 0.0287
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Loa Loa (eye worm) TK/Met protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0061 0.0073
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0028 0.0043 0.1446
Schistosoma mansoni z-protein (S1r protein) 0.0236 0.1495 0.1495
Loa Loa (eye worm) sema domain-containing protein 0.017 0.1035 0.1035
Echinococcus multilocularis regulator of G protein signaling 3 0.0236 0.1495 0.1789
Trichomonas vaginalis serine-threonine protein kinase, putative 0.003 0.0061 0.0407
Brugia malayi Raf kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.017 0.1035 0.1035
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Leishmania major protein kinase, putative 0.0028 0.0043 0.1446
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0028 0.0043 0.1446
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Onchocerca volvulus 0.003 0.0061 0.0235
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.003 0.0061 0.0073
Echinococcus granulosus plexin a4 0.0468 0.3115 0.3729
Echinococcus granulosus ephrin type A receptor 4 A 0.003 0.0061 0.0073
Plasmodium falciparum protein kinase, putative 0.003 0.0061 0.2052
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0074 0.0369 0.2466
Brugia malayi integrin-linked kinase 0.003 0.0061 0.0061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0049 0.5
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase , putative 0.0064 0.0297 0.1985
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0064 0.0297 0.1985
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus tyrosine kinase 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.003 0.0061 0.0073
Echinococcus granulosus activin receptor type 0.0037 0.0104 0.0124
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Echinococcus multilocularis exocyst complex component 2 0.0074 0.0369 0.0441
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.003 0.0061 0.0407
Entamoeba histolytica receptor protein kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0028 0.0043 0.1446
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Onchocerca volvulus 0.003 0.0061 0.0235
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.0061 0.2052
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0061 0.0061
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.003 0.0061 0.0061
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0061 0.0073
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Entamoeba histolytica hypothetical protein 0.0028 0.0043 0.0287
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Onchocerca volvulus 0.003 0.0061 0.0235
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0049 0.0326
Leishmania major protein kinase, putative 0.0037 0.0104 0.3498
Onchocerca volvulus 0.003 0.0061 0.0235
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.0061 0.0061
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.003 0.0061 0.0235
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/ABL protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0061 0.0407
Brugia malayi hypothetical protein 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/KIN6 protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus protein tyrosine kinase 0.003 0.0061 0.0073
Brugia malayi hypothetical protein 0.017 0.1035 0.1035
Echinococcus multilocularis natriuretic peptide receptor 1 0.003 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/DDR protein kinase 0.003 0.0061 0.0061
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0061 0.0061
Entamoeba histolytica ankyrin repeat protein 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi Protein kinase domain containing protein 0.0028 0.0043 0.0043
Onchocerca volvulus 0.017 0.1035 0.3986
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0043 0.0287
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.003 0.0061 0.0407
Onchocerca volvulus 0.0029 0.0049 0.0188
Echinococcus granulosus tyrosine protein kinase shark 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0049
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0083 0.0557
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) SRC-1 0.003 0.0061 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0049 0.0326
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0236 0.1495 0.1495
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi Furin-like cysteine rich region family protein 0.003 0.0061 0.0061
Echinococcus multilocularis protein kinase 0.003 0.0061 0.0073
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus multilocularis tyrosine protein kinase 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.003 0.0061 0.0073
Schistosoma mansoni protein kinase 0.0064 0.0297 0.0297
Mycobacterium ulcerans hypothetical protein 0.0029 0.0049 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.003 0.0061 0.0073
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.01 0.0119
Echinococcus multilocularis tyrosine protein kinase Fgr 0.003 0.0061 0.0073
Trypanosoma brucei Flagellum attachment zone protein 20 0.003 0.0061 0.2052
Schistosoma mansoni ephrin receptor 0.003 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0049 0.5
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi A-kinase anchor protein 10, precursor 0.0236 0.1495 0.1495
Entamoeba histolytica tyrosin kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Echinococcus granulosus tyrosine protein kinase Src64B 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) protein kinase domain-containing protein 0.003 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0369 0.0369
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0028 0.0043 0.1446
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0028 0.0043 0.0287
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.1116 0.763 0.763
Echinococcus multilocularis muscleblind protein 0.018 0.1107 0.1325
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0407
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.0104 0.3498
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase, putative 0.0028 0.0043 0.0287
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0236 0.1495 0.1789
Loa Loa (eye worm) hypothetical protein 0.017 0.1035 0.1035
Brugia malayi Plexin repeat family protein 0.0394 0.2596 0.2596
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0049 0.1641
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.0043 0.0051
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus multilocularis protein dispatched 1 0.0058 0.0255 0.0305
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Echinococcus multilocularis activated cdc42 kinase 1 0.003 0.0061 0.0073
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus tyrosine protein kinase Srms 0.003 0.0061 0.0073
Brugia malayi Tyrosine-protein kinase PR2 0.003 0.0061 0.0061
Echinococcus multilocularis protein tyrosine kinase 0.003 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0028 0.0043 0.1446
Loa Loa (eye worm) hypothetical protein 0.0236 0.1495 0.1495
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.058 0.3883
Loa Loa (eye worm) hypothetical protein 0.0074 0.0369 0.0369
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) hypothetical protein 0.0074 0.0369 0.0369
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.003 0.0061 0.0073
Entamoeba histolytica protein kinase, putative 0.0028 0.0043 0.0287
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0074 0.0369 0.2466
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0061 0.0073
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus aurora kinase A 0.0064 0.0297 0.0355
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.003 0.0061 0.0407
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.0043 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0049 0.0192 0.0192
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0115 0.0652 0.0652
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trypanosoma cruzi NIMA-related kinase, putative 0.0028 0.0043 0.1446
Entamoeba histolytica hypothetical protein, conserved 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Echinococcus granulosus roundabout 2 0.0115 0.0652 0.0781
Echinococcus multilocularis roundabout 2 0.0115 0.0652 0.0781
Brugia malayi SH2 domain containing protein 0.003 0.0061 0.0061
Echinococcus multilocularis plexin a4 0.0468 0.3115 0.3729
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trypanosoma brucei rac serine-threonine kinase, putative 0.0028 0.0043 0.1446
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0028 0.0043 0.1446
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0205 0.0245
Echinococcus multilocularis regulator of G protein signaling 0.0236 0.1495 0.1789
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0043 0.0287
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Brugia malayi ephrin receptor 1 precursor 0.003 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0037 0.0104 0.0104
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0369 0.2466
Toxoplasma gondii protein kinase domain-containing protein 0.0028 0.0043 0.1446
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0205 0.0205
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.1456 1 1
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0061 0.0061
Trypanosoma cruzi protein kinase, putative 0.003 0.0061 0.2052
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1456 1 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.0652 0.0781
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0061 0.0073
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.0104 0.3498
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0205 0.0245
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Echinococcus multilocularis protein patched 0.0051 0.0205 0.0245
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Onchocerca volvulus 0.003 0.0061 0.0235
Echinococcus granulosus semaphorin 5B 0.017 0.1035 0.1239
Schistosoma mansoni hypothetical protein 0.0074 0.0369 0.0369
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.003 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0236 0.1495 0.1495
Echinococcus multilocularis G protein coupled receptor kinase 1 0.088 0.5985 0.7164
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Echinococcus multilocularis hypothetical protein 0.017 0.1035 0.1239
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0028 0.0043 0.1446
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0061 0.0073
Entamoeba histolytica tyrosin kinase, putative 0.003 0.0061 0.0407
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0051 0.0205 0.0205
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Echinococcus granulosus Immunoglobulin 0.0115 0.0652 0.0781
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0115 0.0652 0.0781
Schistosoma mansoni patched 1 0.0051 0.0205 0.0205
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Onchocerca volvulus 0.003 0.0061 0.0235
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0061 0.0073
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.003 0.0061 0.0073
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Schistosoma mansoni protein kinase 0.003 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.1495 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.003 0.0061 0.0073
Echinococcus multilocularis kinase suppressor of Ras 1 0.003 0.0061 0.0073
Brugia malayi hypothetical protein 0.0115 0.0652 0.0652
Trypanosoma cruzi Protein kinase B 0.0028 0.0043 0.1446
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0049 0.1641
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.003 0.0061 0.0073
Echinococcus granulosus regulator of G protein signaling 3 0.0236 0.1495 0.1789
Brugia malayi hypothetical protein 0.017 0.1035 0.1035
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.017 0.1035 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.1495 1
Schistosoma mansoni regulator of G protein signaling 0.0236 0.1495 0.1495
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0043 0.0287
Plasmodium falciparum serine/threonine protein kinase, putative 0.0064 0.0297 1
Loa Loa (eye worm) PXA domain-containing protein 0.0236 0.1495 0.1495
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase, putative 0.0028 0.0043 0.0287
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Echinococcus multilocularis activin receptor type 0.0037 0.0104 0.0124
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus regulator of G protein signaling 7 0.0236 0.1495 0.1789
Leishmania major folate/biopterin transporter, putative 0.0028 0.0043 0.1446
Toxoplasma gondii protein kinase 0.003 0.0061 0.2052
Loa Loa (eye worm) TK protein kinase 0.003 0.0061 0.0061
Entamoeba histolytica receptor protein kinase, putative 0.003 0.0061 0.0407
Plasmodium falciparum protein kinase, putative 0.0037 0.0104 0.3498
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0236 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0061
Echinococcus multilocularis integrin linked protein kinase 0.003 0.0061 0.0073
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Brugia malayi hypothetical protein 0.0236 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.003 0.0061 0.0061
Schistosoma mansoni ephrin receptor 0.003 0.0061 0.0061
Echinococcus multilocularis c src tyrosine kinase 0.003 0.0061 0.0073
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis TK family protein kinase 0.003 0.0061 0.0407
Echinococcus granulosus kinase suppressor of Ras 1 0.003 0.0061 0.0073
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.122 0.8355 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis protein kinase atn1, putative 0.003 0.0061 0.0407
Toxoplasma gondii protein kinase domain-containing protein 0.003 0.0061 0.2052
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Echinococcus granulosus axis inhibition protein axin 0.0236 0.1495 0.1789
Echinococcus multilocularis tyrosine protein kinase Srms 0.003 0.0061 0.0073
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.0061 0.2052
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.003 0.0061 0.0407
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0678 0.4538
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0028 0.0043 0.1446
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.0061 0.0073
Echinococcus multilocularis axis inhibition protein axin 0.0236 0.1495 0.1789
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Entamoeba histolytica protein kinase, putative 0.003 0.0061 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Loa Loa (eye worm) hypothetical protein 0.0115 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0123 0.0123
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.122 0.8355 0.8355
Brugia malayi protein-tyrosine kinase 0.003 0.0061 0.0061
Brugia malayi SRC-1 0.003 0.0061 0.0061
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Echinococcus granulosus natriuretic peptide receptor 1 0.003 0.0061 0.0073
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0061 0.0073
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0061 0.0061
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1116 0.763 0.763
Schistosoma mansoni fibrocystin l 0.0074 0.0369 0.0369
Brugia malayi Protein kinase domain containing protein 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Toxoplasma gondii STE kinase 0.003 0.0061 0.2052
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0407
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0037 0.0104 0.0124
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0061 0.0407
Schistosoma mansoni hypothetical protein 0.0049 0.0192 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0369 0.2466
Onchocerca volvulus 0.003 0.0061 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0369 0.2466
Entamoeba histolytica protein kinase, putative 0.0064 0.0297 0.1985
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0061 0.0407
Entamoeba histolytica cysteine surface protein, putative 0.003 0.0061 0.0407
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0864 0.0864
Echinococcus multilocularis tyrosine kinase 0.003 0.0061 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0083 0.0557
Loa Loa (eye worm) hypothetical protein 0.0074 0.0369 0.0369
Echinococcus granulosus insulin receptor 0.003 0.0061 0.0073
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.0061 0.0061
Echinococcus multilocularis expressed protein 0.0236 0.1495 0.1789
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0407
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Schistosoma mansoni hypothetical protein 0.003 0.0061 0.0061
Onchocerca volvulus 0.003 0.0061 0.0235
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.0104 0.3498
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0043 0.1446
Loa Loa (eye worm) TK/CSK protein kinase 0.003 0.0061 0.0061
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.003 0.0061 0.0073
Echinococcus granulosus transcription factor collier 0.0074 0.0369 0.0441
Echinococcus multilocularis protein KINase family member (kin 25) 0.003 0.0061 0.0073
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0061 0.0407
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0043 0.0287
Entamoeba histolytica hypothetical protein 0.0074 0.0369 0.2466
Schistosoma mansoni plexin 0.0394 0.2596 0.2596
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Loa Loa (eye worm) serine/threonine protein kinase 0.003 0.0061 0.0061
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0037 0.0104 0.3498
Trypanosoma brucei protein kinase, putative 0.0028 0.0043 0.1446
Loa Loa (eye worm) hypothetical protein 0.017 0.1035 0.1035
Echinococcus multilocularis heat shock protein 70 0.003 0.0061 0.0073
Entamoeba histolytica hypothetical protein 0.0074 0.0369 0.2466
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0043 0.0287
Brugia malayi Sema domain containing protein 0.017 0.1035 0.1035
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.003 0.0061 0.0073
Echinococcus multilocularis tyrosine protein kinase ABL1 0.003 0.0061 0.0073
Schistosoma mansoni tyrosine kinase 0.003 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0061 0.0407
Brugia malayi serine/threonine-protein kinase 6 0.0064 0.0297 0.0297
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0061 0.0073

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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