Detailed information for compound 1394547

Basic information

Technical information
  • TDR Targets ID: 1394547
  • Name: N-(2-fluorophenyl)-3-[4-(4-fluorophenyl)sulfo nylpiperazin-1-yl]propanamide
  • MW: 409.45 | Formula: C19H21F2N3O3S
  • H donors: 1 H acceptors: 3 LogP: 1.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1F)CCN1CCN(CC1)S(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C19H21F2N3O3S/c20-15-5-7-16(8-6-15)28(26,27)24-13-11-23(12-14-24)10-9-19(25)22-18-4-2-1-3-17(18)21/h1-8H,9-14H2,(H,22,25)
  • InChiKey: BHMIHHCLJVGFFX-UHFFFAOYSA-N  


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Synonyms

  • N-(2-fluorophenyl)-3-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]propanamide
  • N-(2-fluorophenyl)-3-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Macaaca fascicularis T-complex protein 1 subunit beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia TCP-1 chaperonin subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Neospora caninum TCP-1/cpn60 family chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium yoelii putative T-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium berghei T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Toxoplasma gondii t-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania infantum T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei gambiense T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Theileria parva T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Cryptosporidium hominis TCP-1/cpn60 chaperonin-related protein Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania major T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin-60kD, ch60, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium vivax T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Babesia bovis T-complex protein beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium knowlesi T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Cryptosporidium parvum GroEL-like chaperone (ATpase); T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum ko:K09494 T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania donovani T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Entamoeba histolytica T-complex protein 1 beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium falciparum T-complex protein 1 subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi T-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 534 aa 35.6 %
Giardia lamblia TCP-1 chaperonin subunit theta T-complex protein 1 subunit beta   535 aa 563 aa 25.2 %
Schistosoma mansoni T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex protein 1 subunit beta   535 aa 552 aa 33.5 %
Schistosoma mansoni chaperonin containing t-complex protein 1 delta subunit tcpd T-complex protein 1 subunit beta   535 aa 530 aa 32.8 %
Cryptosporidium parvum putative T complex chaperonin T-complex protein 1 subunit beta   535 aa 546 aa 25.1 %
Schistosoma japonicum ko:K09497 T-complex protein 1 subunit epsilon, putative T-complex protein 1 subunit beta   535 aa 505 aa 33.5 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 528 aa 20.8 %
Plasmodium vivax T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 539 aa 22.4 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 533 aa 33.8 %
Giardia lamblia TCP-1 chaperonin subunit epsilon T-complex protein 1 subunit beta   535 aa 535 aa 31.6 %
Giardia lamblia TCP-1 chaperonin subunit eta T-complex protein 1 subunit beta   535 aa 543 aa 32.0 %
Leishmania donovani T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.8 %
Dictyostelium discoideum chaperonin containing TCP1 zeta subunit T-complex protein 1 subunit beta   535 aa 523 aa 26.6 %
Neospora caninum Thermosome subunit, related T-complex protein 1 subunit beta   535 aa 527 aa 31.3 %
Leishmania major chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Babesia bovis t-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Plasmodium yoelii T-complex protein 1 epsilon subunit T-complex protein 1 subunit beta   535 aa 508 aa 32.9 %
Toxoplasma gondii T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Toxoplasma gondii T-complex protein 1 eta subunit T-complex protein 1 subunit beta   535 aa 546 aa 33.9 %
Entamoeba histolytica T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 31.6 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 29.8 %
Trypanosoma cruzi chaperonin/T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 30.9 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Plasmodium knowlesi T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.7 %
Plasmodium berghei T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 537 aa 23.5 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Leishmania major chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.1 %
Leishmania donovani T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Plasmodium falciparum T-complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 539 aa 23.4 %
Neospora caninum GL18351, related T-complex protein 1 subunit beta   535 aa 530 aa 26.2 %
Schistosoma mansoni chaperonin containing t-complex protein 1 eta subunit tcph T-complex protein 1 subunit beta   535 aa 536 aa 32.8 %
Plasmodium berghei T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 523 aa 30.2 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 550 aa 32.9 %
Plasmodium yoelii T-complex protein 1 T-complex protein 1 subunit beta   535 aa 534 aa 26.2 %
Leishmania braziliensis T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 29.1 %
Leishmania mexicana T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.6 %
Leishmania infantum chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Echinococcus granulosus T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Leishmania infantum chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Trypanosoma cruzi T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Babesia bovis TCP-1/cpn60 chaperonin family protein T-complex protein 1 subunit beta   535 aa 538 aa 30.5 %
Schistosoma japonicum ko:K09499 T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Cryptosporidium hominis t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Loa Loa (eye worm) T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 514 aa 26.5 %
Plasmodium vivax T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Leishmania braziliensis chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 542 aa 26.2 %
Trypanosoma congolense T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 28.6 %
Echinococcus multilocularis T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 27.1 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.2 %
Brugia malayi T-complex protein 1, epsilon subunit T-complex protein 1 subunit beta   535 aa 513 aa 31.4 %
Entamoeba histolytica T-complex protein 1 theta subunit, putative T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Plasmodium berghei T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 539 aa 34.1 %
Entamoeba histolytica chaperonin containing TCP-1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 508 aa 32.7 %
Toxoplasma gondii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 531 aa 29.2 %
Onchocerca volvulus Integrator complex subunit 3 homolog T-complex protein 1 subunit beta   535 aa 534 aa 35.8 %
Cryptosporidium parvum T complex chaperonin T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Leishmania mexicana chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.6 %
Theileria parva T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 27.1 %
Echinococcus multilocularis T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Echinococcus multilocularis t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Trypanosoma brucei gambiense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Entamoeba histolytica T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 29.9 %
Trypanosoma congolense t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 545 aa 29.7 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Trypanosoma brucei gambiense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Cryptosporidium hominis T-complex protein 1 T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Cryptosporidium hominis CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 536 aa 28.4 %
Plasmodium vivax T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Schistosoma mansoni chaperonin containing t-complex protein 1 gamma subunit tcpg T-complex protein 1 subunit beta   535 aa 552 aa 29.7 %
Plasmodium falciparum T-complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 546 aa 34.4 %
Trypanosoma brucei T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.4 %
Schistosoma mansoni chaperonin containing t-complex protein 1 theta subunit tcpq T-complex protein 1 subunit beta   535 aa 515 aa 27.2 %
Drosophila melanogaster T-complex Chaperonin 5 T-complex protein 1 subunit beta   535 aa 506 aa 34.6 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.4 %
Cryptosporidium parvum TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Plasmodium yoelii putative chaperonin T-complex protein 1 subunit beta   535 aa 497 aa 22.7 %
Echinococcus granulosus T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 34.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 579 aa 23.1 %
Leishmania infantum T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Plasmodium knowlesi T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.1 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Trypanosoma brucei t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.6 %
Babesia bovis T-complex protein 1 zeta subunit T-complex protein 1 subunit beta   535 aa 532 aa 26.7 %
Babesia bovis HSP60 fold T-complex protein 1, putative T-complex protein 1 subunit beta   535 aa 497 aa 28.0 %
Entamoeba histolytica hypothetical protein T-complex protein 1 subunit beta   535 aa 516 aa 22.5 %
Plasmodium vivax T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Trypanosoma brucei T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Leishmania donovani chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trypanosoma brucei T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Echinococcus multilocularis chaperonin containing TCP1, subunit 5 (epsilon) T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Trypanosoma cruzi T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 29.5 %
Babesia bovis T-complex protein 1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 32.6 %
Leishmania donovani T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Brugia malayi T-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 529 aa 28.4 %
Echinococcus granulosus T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 517 aa 27.1 %
Leishmania braziliensis T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Leishmania mexicana T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.2 %
Trypanosoma brucei gambiense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Dictyostelium discoideum chaperonin containing TCP1 epsilon subunit T-complex protein 1 subunit beta   535 aa 520 aa 34.4 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 542 aa 27.7 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 533 aa 28.3 %
Dictyostelium discoideum chaperonin containing TCP1 alpha subunit T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Leishmania braziliensis T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Neospora caninum hypothetical protein T-complex protein 1 subunit beta   535 aa 531 aa 29.0 %
Leishmania donovani T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Trypanosoma brucei T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Schistosoma mansoni chaperonin containing t-complex protein 1 epsilon subunit tcpe T-complex protein 1 subunit beta   535 aa 505 aa 33.9 %
Echinococcus granulosus t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 575 aa 23.1 %
Leishmania infantum T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Leishmania major chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.3 %
Plasmodium yoelii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 523 aa 30.0 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Toxoplasma gondii TCP-1 chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 26.9 %
Echinococcus multilocularis T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Trypanosoma congolense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 525 aa 34.1 %
Trypanosoma brucei T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Plasmodium berghei T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 561 aa 23.0 %
Leishmania braziliensis chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Giardia lamblia TCP-1 chaperonin subunit zeta T-complex protein 1 subunit beta   535 aa 516 aa 24.8 %
Plasmodium berghei T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 526 aa 25.7 %
Schistosoma mansoni chaperonin containing t-complex protein 1 zeta subunit tcpz T-complex protein 1 subunit beta   535 aa 544 aa 26.3 %
Leishmania mexicana chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 538 aa 26.8 %
Leishmania donovani chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.5 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 547 aa 32.7 %
Brugia malayi T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 502 aa 26.3 %
Trypanosoma congolense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 521 aa 29.6 %
Echinococcus granulosus chaperonin containing TCP1 subunit 5 epsilon T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Trypanosoma cruzi chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 528 aa 33.0 %
Leishmania mexicana chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.3 %
Theileria parva T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 522 aa 32.4 %
Leishmania infantum chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.7 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Mycobacterium tuberculosis 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a T-complex protein 1 subunit beta   535 aa 565 aa 23.5 %
Cryptosporidium parvum conserved probable chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.7 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 604 aa 22.9 %
Cryptosporidium parvum t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Trichomonas vaginalis chaperonin-60kD, ch60, putative T-complex protein 1 subunit beta   535 aa 538 aa 33.6 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 546 aa 33.7 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Leishmania infantum T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.4 %
Trypanosoma brucei gambiense T-complex protein 1, theta subunit, putative,CCT-theta, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Plasmodium knowlesi T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 33.7 %
Toxoplasma gondii T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.8 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Trypanosoma congolense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.4 %
Theileria parva T-complex protein 1, alpha subunit , putative T-complex protein 1 subunit beta   535 aa 527 aa 34.9 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Trichomonas vaginalis rubisco subunit binding-protein alpha subunit, ruba, putative T-complex protein 1 subunit beta   535 aa 580 aa 23.3 %
Babesia bovis heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 530 aa 22.3 %
Leishmania donovani chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Leishmania infantum T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Loa Loa (eye worm) CCT-5 protein T-complex protein 1 subunit beta   535 aa 521 aa 31.3 %
Plasmodium falciparum T-complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 542 aa 34.9 %
Leishmania major T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 28.8 %
Brugia malayi T-complex protein 1, eta subunit T-complex protein 1 subunit beta   535 aa 534 aa 33.1 %
Trypanosoma brucei gambiense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Toxoplasma gondii T-complex protein 1 delta subunit T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 561 aa 27.1 %
Echinococcus granulosus T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.5 %
Leishmania braziliensis chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Plasmodium vivax T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.3 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 549 aa 35.7 %
Plasmodium knowlesi T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 526 aa 31.0 %
Schistosoma japonicum ko:K09498 T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 552 aa 25.7 %
Brugia malayi T-complex protein 1, zeta subunit T-complex protein 1 subunit beta   535 aa 517 aa 27.7 %
Leishmania mexicana T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 35.1 %
Leishmania major T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.8 %
Leishmania major T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.5 %
Schistosoma japonicum ko:K09493 T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 585 aa 31.5 %
Theileria parva chaperonin 60 kDa, putative T-complex protein 1 subunit beta   535 aa 544 aa 26.1 %
Giardia lamblia TCP-1 chaperonin subunit alpha T-complex protein 1 subunit beta   535 aa 528 aa 32.6 %
Leishmania major T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.3 %
Dictyostelium discoideum chaperonin containing TCP1 theta subunit T-complex protein 1 subunit beta   535 aa 501 aa 27.1 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Plasmodium falciparum T-complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 522 aa 29.9 %
Leishmania braziliensis T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 550 aa 32.0 %
Trypanosoma brucei gambiense T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.4 %
Plasmodium yoelii chaperonin, 60 kDa T-complex protein 1 subunit beta   535 aa 530 aa 34.9 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Plasmodium knowlesi T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 544 aa 23.5 %
Dictyostelium discoideum chaperonin containing TCP1 eta subunit T-complex protein 1 subunit beta   535 aa 528 aa 33.5 %
Cryptosporidium hominis chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.9 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Trypanosoma brucei T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Theileria parva T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 580 aa 33.3 %
Plasmodium falciparum T-complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 23.1 %
Plasmodium vivax heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 540 aa 21.9 %
Entamoeba histolytica chaperonin containing TCP-1 delta subunit, putative T-complex protein 1 subunit beta   535 aa 531 aa 30.7 %
Trypanosoma brucei gambiense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Trypanosoma congolense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 32.2 %
Toxoplasma gondii T complex chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.0 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Drosophila melanogaster CG8351 gene product from transcript CG8351-RA T-complex protein 1 subunit beta   535 aa 527 aa 32.3 %
Schistosoma japonicum ko:K09496 T-complex protein 1 subunit delta, putative T-complex protein 1 subunit beta   535 aa 533 aa 32.1 %
Cryptosporidium parvum putative t-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 545 aa 28.3 %
Trypanosoma cruzi T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 29.7 %
Entamoeba histolytica chaperonin-containing TCP-1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 550 aa 23.5 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 33.5 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, beta subunit, tcpb, putative T-complex protein 1 subunit beta   535 aa 541 aa 35.5 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 549 aa 20.6 %
Giardia lamblia TCP-1 chaperonin subunit gamma T-complex protein 1 subunit beta   535 aa 561 aa 29.8 %
Cryptosporidium hominis CCTepsilon subunit T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Trypanosoma cruzi chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 547 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0282 0.0045
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0094 0.1161 0.1148
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0015 0.0015
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0013 0.0015 0.0015
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0238 0.0238
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0094 0.1161 0.0945
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0488 0.0488
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Entamoeba histolytica casein kinase, putative 0.0717 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0032 0.0282 0.0045
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0159 0.2078 0.1885
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0282 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0282 0.0282
Trichomonas vaginalis CMGC family protein kinase 0.0717 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0432 0.0432
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0238 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0282 0.0045
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0717 1 1
Giardia lamblia hypothetical protein 0.0032 0.0282 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0282 0.0045
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0268
Plasmodium vivax unspecified product 0.0717 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0282 0.0045
Giardia lamblia Kinase, CMGC GSK 0.0159 0.2078 0.1885
Loa Loa (eye worm) PDE1B protein 0.0229 0.3078 0.3078
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0032 0.0282 0.0282
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.0238 0.0224
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0094 0.1161 0.0945
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.0238 0.0238
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.012 0.1523 0.1523
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Brugia malayi intracellular kinase 0.0159 0.2078 0.2078
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0392 0.0158
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0432 0.0432
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus multilocularis protein kinase shaggy 0.0159 0.2078 0.2078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Entamoeba histolytica protein kinase domain containing protein 0.0159 0.2078 0.1885
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0543 0.7534 0.7534
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0322 0.0308
Schistosoma mansoni protein kinase 0.0717 1 1
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.0238 0.0224
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0238 0.0238
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.012 0.1523 0.1523
Trichomonas vaginalis CMGC family protein kinase 0.0717 1 1
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0543 0.7534 0.7534
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0032 0.0282 0.0268
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Leishmania major casein kinase II, putative 0.0717 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma cruzi casein kinase II, putative 0.0717 1 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0032 0.0282 0.0282
Leishmania major cAMP-specific phosphodiesterase, putative 0.0032 0.0282 0.0268
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0268
Echinococcus granulosus casein kinase ii subunit alpha 0.0717 1 1
Loa Loa (eye worm) AGC/PKG protein kinase 0.0013 0.0015 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0123 0.1563 0.155
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0229 0.3078 0.3078
Schistosoma mansoni serine/threonine protein kinase 0.0543 0.7534 0.7534
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0032 0.0282 0.0045
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.012 0.1523 0.1523
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0282 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0717 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Loa Loa (eye worm) hypothetical protein 0.012 0.1523 0.1523
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0282 0.0045
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0238 0.0238
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0478 0.661 0.661
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0087 0.1064 0.1064
Echinococcus multilocularis casein kinase ii subunit alpha 0.0717 1 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0282 0.0282
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0159 0.2078 0.2066
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0032 0.0282 0.0282
Echinococcus granulosus protein kinase shaggy 0.0159 0.2078 0.2078
Trichomonas vaginalis CMGC family protein kinase 0.0717 1 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.0238 0.0238
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.012 0.1523 0.1316
Loa Loa (eye worm) hypothetical protein 0.0032 0.0282 0.0282
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0094 0.1161 0.1161
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Plasmodium falciparum phosphodiesterase gamma, putative 0.0032 0.0282 0.0268
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Plasmodium falciparum glycogen synthase kinase 3 0.0159 0.2078 0.2066
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.2078 0.1885
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0094 0.1161 0.1161
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0488 0.0488
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0032 0.0282 0.0282
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0094 0.1161 0.1148
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0159 0.2078 0.2078
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0087 0.1064 0.1064
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Loa Loa (eye worm) T-complex protein 1 0.0029 0.0238 0.0238
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.012 0.1523 0.1523
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0032 0.0282 0.0282
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0032 0.0282 0.0282
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0032 0.0282 0.0282
Giardia lamblia Kinase, CMGC GSK 0.0159 0.2078 0.1885
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0159 0.2078 0.2078
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0159 0.2078 0.2078
Entamoeba histolytica protein kinase domain containing protein 0.0543 0.7534 0.7474
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0094 0.1161 0.0945
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0032 0.0282 0.0282
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0032 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0446 0.6151 0.6151
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0032 0.0282 0.0282
Brugia malayi Egg laying defective protein 4 0.0013 0.0015 0.0015
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0013 0.0015 0.0015
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0282 0.0282
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0087 0.1064 0.1064
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0229 0.3078 0.3078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0094 0.1161 0.1148
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0229 0.3078 0.3078
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0094 0.1161 0.0945
Giardia lamblia Kinase, CMGC CK2 0.0717 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0229 0.3078 0.3078
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0159 0.2078 0.2078
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0032 0.0282 0.0282
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0015 0.0015
Giardia lamblia Hypothetical protein 0.0032 0.0282 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0159 0.2078 0.1885
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0159 0.2078 0.2066
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0282 0.0282
Entamoeba histolytica protein kinase domain containing protein 0.0717 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma brucei protein kinase, putative 0.0159 0.2078 0.1885
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus multilocularis expressed conserved protein 0.0013 0.0015 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0015 0.0015
Echinococcus granulosus cGMP dependent protein kinase 1 0.0013 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0032 0.0282 0.0268
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0032 0.0282 0.0282
Plasmodium vivax phosphodiesterase gamma, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0032 0.0282 0.0045
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0717 1 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0032 0.0282 0.0268
Trichomonas vaginalis CMGC family protein kinase 0.0717 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0032 0.0282 0.0282
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0717 1 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0032 0.0282 0.0282
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Entamoeba histolytica protein kinase, putative 0.0159 0.2078 0.1885
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0282 0.0282
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0543 0.7534 0.7534
Onchocerca volvulus 0.0159 0.2078 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0032 0.0282 0.0268
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0238 0.0238
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0717 1 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.0238 0.0224
Toxoplasma gondii CMGC kinase, CK2 family 0.0717 1 1
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0543 0.7534 0.7534
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0282 0.0045
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0032 0.0282 0.0282
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0432 0.0432
Trypanosoma brucei Casein kinase II 0.0717 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0087 0.1064 0.1064
Echinococcus granulosus cGMP dependent protein kinase 1 0.0013 0.0015 0.0015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0392 0.0158
Echinococcus granulosus cGMP dependent protein kinase 0.0013 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0282 0.0045
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0159 0.2078 0.2078
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0432 0.0432
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0032 0.0282 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.2078 0.1885
Leishmania major hypothetical protein, conserved 0.0032 0.0282 0.0268
Loa Loa (eye worm) hypothetical protein 0.0478 0.661 0.661
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0282 0.0045
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0282 0.0045
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0032 0.0282 0.0282
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.012 0.1523 0.1523
Plasmodium vivax glycogen synthase kinase 3, putative 0.0159 0.2078 0.1885
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0282 0.0045
Plasmodium falciparum casein kinase 2, alpha subunit 0.0717 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0282 0.0268
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0032 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0037 0.0352 0.0352
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0282 0.0282

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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