TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.333 | Formula: C16H11BrN6S2
H donors: 1 H acceptors: 3 LogP: 4.33 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(s1)C=Nn1c(S)nnc1c1n[nH]c(c1)c1ccccc1
InChi: 1S/C16H11BrN6S2/c17-14-7-6-11(25-14)9-18-23-15(21-22-16(23)24)13-8-12(19-20-13)10-4-2-1-3-5-10/h1-9H,(H,19,20)(H,22,24)
InChiKey: HHBWEIPXSCZNHO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin-conjugating enzyme E2I	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	SUMO-conjugating enzyme UBC9, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Giardia lamblia	UBC3	Get druggable targets OG5_127729	All targets in OG5_127729
Babesia bovis	ubiquitin conjugating enzyme, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Leishmania braziliensis	ubiquitin-conjugating enzyme e2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Plasmodium knowlesi	SUMO-conjugating enzyme UBC9, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Babesia bovis	ubiquitin conjugating enzyme, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Neospora caninum	Ubiquitin carrier protein (EC 6.3.2.-), related	Get druggable targets OG5_127729	All targets in OG5_127729
Leishmania mexicana	ubiquitin-conjugating enzyme e2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Theileria parva	ubiquitin-conjugating enzyme, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Echinococcus granulosus	ubiquitin conjugating enzyme e2 i	Get druggable targets OG5_127729	All targets in OG5_127729
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	Get druggable targets OG5_127729	All targets in OG5_127729
Loa Loa (eye worm)	ube2i2 protein	Get druggable targets OG5_127729	All targets in OG5_127729
Candida albicans	ubiquitin-conjugating enzyme	Get druggable targets OG5_127729	All targets in OG5_127729
Leishmania major	ubiquitin-conjugating enzyme e2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	Get druggable targets OG5_127729	All targets in OG5_127729
Trypanosoma brucei	ubiquitin-conjugating enzyme E2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Leishmania infantum	ubiquitin-conjugating enzyme e2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Cryptosporidium parvum	ubiquitin conjugating enzyme, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Schistosoma japonicum	ko:K10577 ubiquitin-conjugating enzyme E2 I, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Leishmania donovani	ubiquitin-conjugating enzyme E2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Schistosoma mansoni	ubiquitin-conjugating enzyme E2 I	Get druggable targets OG5_127729	All targets in OG5_127729
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Brugia malayi	ube2i2 protein	Get druggable targets OG5_127729	All targets in OG5_127729
Plasmodium vivax	SUMO-conjugating enzyme UBC9, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Trichomonas vaginalis	ubiquitin-conjugating enzyme rad6, putative	Get druggable targets OG5_127729	All targets in OG5_127729
Candida albicans	ubiquitin-conjugating enzyme	Get druggable targets OG5_127729	All targets in OG5_127729
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	Get druggable targets OG5_127729	All targets in OG5_127729
Plasmodium falciparum	SUMO-conjugating enzyme UBC9	Get druggable targets OG5_127729	All targets in OG5_127729
Echinococcus multilocularis	ubiquitin conjugating enzyme e2 i	Get druggable targets OG5_127729	All targets in OG5_127729
Trypanosoma brucei gambiense	ubiquitin-conjugating enzyme e2, putative	Get druggable targets OG5_127729	All targets in OG5_127729

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin-conjugating enzyme E2, putative	ubiquitin-conjugating enzyme E2I	158 aa	154 aa	40.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0257	0.0116	0.4051
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.003	0.0003	0.0011
Loa Loa (eye worm)	ThiF family protein	0.0038	0.0007	0.0042
Toxoplasma gondii	hypothetical protein	0.0043	0.001	0.0021
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0028	0.0002	0.0035
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.001	0.0209
Echinococcus granulosus	voltage dependent calcium channel	0.0057	0.0016	0.0397
Brugia malayi	mbt repeat family protein	0.0058	0.0017	0.0409
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.0017	0.0409
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0028	0.0002	0.0002
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0033	0.0005	0.006
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.001	0.001
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0151	0.0063	0.2147
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0008	0.0183
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.001	0.0244
Toxoplasma gondii	hypoxia- inducible factor prolyl hydroxylase (phd2), putative	0.0591	0.0281	0.0682
Brugia malayi	Cytochrome P450 family protein	0.004	0.0008	0.0183
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0037	0.0007	0.0007
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0057	0.0016	0.0104
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.0021	0.0021
Echinococcus multilocularis	prolyl 4 hydroxylase subunit alpha 1	0.0591	0.0281	0.5926
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0018	0.0115
Echinococcus granulosus	prolyl 4 hydroxylase subunit alpha 1	0.0591	0.0281	0.7203
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.0021	0.042
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.081	0.039	0.2608
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0009	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0002	0.0009
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0058	0.0017	0.0343
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0028	0.0002	0.0035
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.001	0.0201
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0018	0.0442
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0016	0.0312
Plasmodium falciparum	plasmepsin I	0.081	0.039	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0009	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0591	0.0281	0.1878
Plasmodium falciparum	plasmepsin VI	0.081	0.039	1
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.003	0.0003	0.0011
Echinococcus granulosus	hyperpolarization activated cyclic	0.0028	0.0002	0.0035
Toxoplasma gondii	hypothetical protein	0.0059	0.0017	0.004
Brugia malayi	Pepsin A precursor	0.081	0.039	1
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.003	0.0003	0.2447
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0037	0.0007	0.0147
Plasmodium vivax	aspartyl proteinase, putative	0.081	0.039	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0257	0.0116	0.4051
Plasmodium falciparum	plasmepsin V	0.081	0.039	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.0007	0.0167
Plasmodium vivax	SUMO-activating enzyme subunit 2, putative	0.0038	0.0007	0.0163
Loa Loa (eye worm)	ICD-1 protein	0.0042	0.0009	0.0055
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.001	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0243	0.0109	0.2277
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0243	0.0109	0.0109
Schistosoma mansoni	voltage-gated cation channel	0.0243	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.006	0.0018	0.0115
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0058	0.0017	0.0017
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0084	1
Brugia malayi	mbt repeat family protein	0.0058	0.0017	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0017	0.0109
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0227	0.0101	0.2112
Brugia malayi	Ubiquitin-like protein SMT3	0.0037	0.0007	0.0147
Trypanosoma cruzi	small ubiquitin protein, putative	0.0037	0.0007	0.0133
Trichomonas vaginalis	ubiquitin-conjugating enzyme rad6, putative	0.003	0.0003	0.0025
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0037	0.0007	0.0014
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.0021	0.051
Plasmodium falciparum	plasmepsin X	0.081	0.039	1
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0009	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0043	0.001	0.0059
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0074	0.2549
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.0017	0.0336
Echinococcus granulosus	sumo-activating enzyme subunit 2	0.0038	0.0007	0.0163
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.0591	0.0281	0.0682
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0016	0.0099
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0243	0.0109	0.2768
Plasmodium vivax	aspartyl proteinase, putative	0.081	0.039	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0014	0.0387
Plasmodium vivax	plasmepsin IV, putative	0.081	0.039	1
Echinococcus granulosus	citrate lyase subunit beta protein	0.003	0.0003	0.0052
Schistosoma mansoni	ubiquitin-conjugating enzyme E2 I	0.003	0.0003	0.0003
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0074	0.2549
Plasmodium falciparum	plasmepsin IX	0.081	0.039	1
Plasmodium falciparum	SUMO-conjugating enzyme UBC9	0.003	0.0003	0.006
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.001	0.0209
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0028	0.0002	0.0029
Trypanosoma brucei	transcription factor BTF3, putative	0.0042	0.0009	0.0214
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.001	0.0209
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0008	0.0048
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.001	0.0201
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.0017	0.0336
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.081	0.039	0.8227
Plasmodium vivax	plasmepsin V, putative	0.081	0.039	1
Schistosoma mansoni	prolyl 4-hydroxylase alpha subunit 1	0.0591	0.0281	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0007	0.0044
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0151	0.0063	0.2156
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.001	0.0244
Schistosoma mansoni	transcription factor btf3	0.0042	0.0009	0.0009
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0014	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0016	0.0104
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0007	0.0007
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0017	0.0017
Trypanosoma cruzi	2OG-Fe(II) oxygenase superfamily, putative	0.0591	0.0281	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0039	0.0007	0.0167
Plasmodium falciparum	plasmepsin VII	0.081	0.039	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0119	0.0047	0.031
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.0474	1
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0053	0.0014	0.0014
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.081	0.039	0.0947
Echinococcus multilocularis	ubiquitin conjugating enzyme e2 i	0.003	0.0003	0.0049
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.001	0.0244
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0028	0.0002	0.0002
Loa Loa (eye worm)	SMO-1 protein	0.0037	0.0007	0.0038
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.081	0.039	1
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.8311	0.4113	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0169	0.5973
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.003	0.0003	0.0017
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0243	0.0109	0.2768
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0074	0.2541
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0016	0.0312
Leishmania major	small ubiquitin protein, putative	0.0037	0.0007	0.0133
Plasmodium falciparum	plasmepsin II	0.081	0.039	1
Trypanosoma brucei	cytochrome P450, putative	0.004	0.0008	0.0172
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0028	0.0002	0.0009
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0243	0.0109	0.2277
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.003	0.0003	0.2447
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0105	0.0041	0.0987
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.081	0.039	0.2608
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0028	0.0002	0.0002
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0028	0.0002	0.0029
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.001	0.001
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.0017	0.0107
Toxoplasma gondii	transporter, cation channel family protein	0.0057	0.0016	0.0038
Brugia malayi	Cytochrome P450 family protein	0.0061	0.0019	0.0453
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0016	0.0379
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.0021	0.051
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0028	0.0002	0.0009
Giardia lamblia	Sentrin	0.0037	0.0007	0.4733
Brugia malayi	Cytochrome P450 family protein	0.004	0.0008	0.0183
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0016	0.0379
Trypanosoma brucei	small ubiquitin-related modifier	0.0037	0.0007	0.0122
Plasmodium vivax	aspartyl protease, putative	0.081	0.039	1
Leishmania major	hypothetical protein, conserved	0.0591	0.0281	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0028	0.0002	0.0002
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.081	0.039	0.0947
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.0019	0.0118
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.001	0.0269
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.0021	0.042
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0019	0.0587
Loa Loa (eye worm)	aspartyl protease 6	0.081	0.039	0.2608
Leishmania major	hypothetical protein, unknown function	0.0591	0.0281	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0028	0.0002	0.0035
Toxoplasma gondii	aspartyl protease ASP3	0.081	0.039	0.0947
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0008	0.0183
Plasmodium falciparum	SUMO-activating enzyme subunit 2	0.0038	0.0007	0.0163
Schistosoma mansoni	hypothetical protein	0.035	0.0162	0.0162
Echinococcus granulosus	hyperpolarization activated cyclic	0.0028	0.0002	0.0035
Loa Loa (eye worm)	calcium channel	0.0243	0.0109	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0017	0.0107
Brugia malayi	hypothetical protein	0.081	0.039	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0051	0.0014	0.0376
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.0007	0.0138
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.001	0.0244
Trypanosoma cruzi	2OG-Fe(II) oxygenase superfamily, putative	0.0591	0.0281	1
Schistosoma mansoni	ubiquitin-activating enzyme E1b	0.0038	0.0007	0.0007
Echinococcus multilocularis	SUMO activating enzyme subunit 2	0.0038	0.0007	0.0134
Plasmodium vivax	aspartyl protease, putative	0.081	0.039	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.001	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0009	0.0178
Toxoplasma gondii	tetratricopeptide repeat-containing protein	0.0591	0.0281	0.0682
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0016	0.0016
Brugia malayi	ThiF family protein	0.0038	0.0007	0.0163
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0038	0.0007	0.0155
Echinococcus multilocularis	voltage gated potassium channel	0.0039	0.0007	0.0138
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0028	0.0002	0.0035
Schistosoma mansoni	cathepsin D (A01 family)	0.081	0.039	0.039
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0243	0.0109	0.2277
Leishmania major	basic transcription factor 3a, putative	0.0042	0.0009	0.0225
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0058	0.0017	0.0417
Brugia malayi	aspartic protease BmAsp-1, identical	0.081	0.039	1
Plasmodium vivax	SUMO-conjugating enzyme UBC9, putative	0.003	0.0003	0.006
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.004	0.0008	0.0632
Toxoplasma gondii	hypothetical protein	0.0058	0.0017	0.0039
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0037	0.0007	0.0121
Brugia malayi	prolyl 4-hydroxylase	0.0591	0.0281	0.7203
Schistosoma mansoni	hypothetical protein	0.0041	0.0009	0.0009
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0009	0.0199
Brugia malayi	aspartic protease BmAsp-2, identical	0.081	0.039	1
Plasmodium vivax	basic transcription factor 3b, putative	0.0042	0.0009	0.0213
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0119	0.0047	0.1189
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0227	0.0101	0.2568
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.0169	0.5968
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.003	0.0003	0.0011
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.001	0.0201
Leishmania major	cytochrome p450-like protein	0.004	0.0008	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0043	0.001	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0104	0.004	0.0261
Loa Loa (eye worm)	hypothetical protein	0.081	0.039	0.2608
Trypanosoma cruzi	transcription factor btf3, putative	0.0042	0.0009	0.0225
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.0021	0.051
Echinococcus multilocularis	voltage dependent calcium channel	0.0243	0.0109	0.2277
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0028	0.0002	0.0002
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0119	0.0047	0.0978
Echinococcus multilocularis	sodium channel protein	0.0107	0.0041	0.0857
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.0017	0.0017
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0107	0.0041	0.1041
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0007	0.0007
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0243	0.0109	0.2768
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0008	0.0048
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0028	0.0002	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0045	0.001	0.0064
Plasmodium falciparum	small ubiquitin-related modifier	0.0037	0.0007	0.0147
Plasmodium vivax	aspartyl protease, putative	0.081	0.039	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.0058	0.0017	0.0417
Echinococcus granulosus	transcription factor btf3	0.0042	0.0009	0.0213
Toxoplasma gondii	aspartyl protease	0.081	0.039	0.0947
Loa Loa (eye worm)	CYP4Cod1	0.004	0.0008	0.0048
Entamoeba histolytica	ubiquitin like protein	0.0037	0.0007	0.6022
Schistosoma mansoni	voltage-gated potassium channel	0.0028	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.081	0.039	0.2608
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Trypanosoma cruzi	hypothetical protein, conserved	0.0257	0.0116	0.4051
Onchocerca volvulus		0.0591	0.0281	0.7084
Toxoplasma gondii	aspartyl protease ASP1	0.081	0.039	0.0947
Toxoplasma gondii	ThiF family protein	0.0038	0.0007	0.0015
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0243	0.0109	0.2277
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0016	0.0016
Trypanosoma brucei	hypothetical protein, conserved	0.0257	0.0116	0.4045
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0169	0.5973
Loa Loa (eye worm)	hypothetical protein	0.0243	0.0109	0.0722
Echinococcus granulosus	voltage dependent calcium channel	0.0243	0.0109	0.2768
Loa Loa (eye worm)	hypothetical protein	0.3035	0.1494	1
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0028	0.0002	0.0035
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0058	0.0017	0.0417
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.001	0.0269
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0119	0.0047	0.1189
Loa Loa (eye worm)	ube2i2 protein	0.003	0.0003	0.0016
Trypanosoma cruzi	small ubiquitin protein, putative	0.0037	0.0007	0.0133
Schistosoma mansoni	voltage-gated potassium channel	0.0129	0.0052	0.0052
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0014	0.0387
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0105	0.0041	0.0987
Loa Loa (eye worm)	hypothetical protein	0.081	0.039	0.2608
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0018	0.0442
Brugia malayi	beta-NAC-like protein	0.0042	0.0009	0.0213
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0243	0.0109	0.0109
Brugia malayi	ThiF family protein	0.0058	0.0017	0.0417
Loa Loa (eye worm)	prolyl 4-hydroxylase 2	0.0591	0.0281	0.1878
Echinococcus granulosus	Small ubiquitin modifier 2	0.0037	0.0007	0.0147
Brugia malayi	hypothetical protein	0.081	0.039	1
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.0591	0.0281	0.0682
Plasmodium falciparum	plasmepsin IV	0.081	0.039	1
Toxoplasma gondii	NAC domain-containing protein	0.0042	0.0009	0.002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0016	0.0016
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.0169	0.5973
Plasmodium falciparum	plasmepsin III	0.081	0.039	1
Loa Loa (eye worm)	MBCTL1	0.0066	0.0021	0.0133
Trypanosoma cruzi	transcription factor btf3, putative	0.0042	0.0009	0.0225
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.0017	0.0409
Entamoeba histolytica	transcription factor BTF3, putative	0.0042	0.0009	0.8727
Echinococcus granulosus	ubiquitin conjugating enzyme e2 i	0.003	0.0003	0.006
Leishmania major	ubiquitin-activating enzyme-like protein	0.0038	0.0007	0.0155
Plasmodium falciparum	basic transcription factor 3b, putative	0.0042	0.0009	0.0213
Brugia malayi	Eukaryotic aspartyl protease family protein	0.081	0.039	1
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0007	0.0112
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0243	0.0109	0.2768
Echinococcus multilocularis	transcription factor btf3	0.0042	0.0009	0.0175
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0028	0.0002	0.0029
Plasmodium falciparum	plasmepsin VIII, putative	0.081	0.039	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0021	0.0133
Schistosoma mansoni	cathepsin D (A01 family)	0.081	0.039	0.039
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.003	0.0003	0.0006
Brugia malayi	ube2i2 protein	0.003	0.0003	0.006
Onchocerca volvulus		0.081	0.039	1
Trypanosoma brucei	2OG-Fe(II) oxygenase superfamily, putative	0.0591	0.0281	1
Echinococcus multilocularis	citrate lyase subunit beta protein	0.003	0.0003	0.0043
Mycobacterium ulcerans	hypothetical protein	0.0192	0.0084	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0243	0.0109	0.2277
Echinococcus granulosus	voltage gated potassium channel	0.0039	0.0007	0.0167
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.001	0.0258
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0028	0.0002	0.0029
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0016	0.0379
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.081	0.039	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.081	0.039	0.039
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0038	0.0007	0.0144
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.001	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0009	0.8727
Schistosoma mansoni	voltage-gated potassium channel	0.0129	0.0052	0.0052
Onchocerca volvulus		0.081	0.039	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 11.3 uM	PUBCHEM_BIOASSAY: SAR analysis of SUMOylation using HTRF in an in-Vitro dose response assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2018, AID2069, AID2658]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1519689

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1395821