Detailed information for compound 1396892

Basic information

Technical information
  • TDR Targets ID: 1396892
  • Name: 4-methoxy-N-(1-methylsulfanyl-2-nitroethenyl) aniline
  • MW: 240.279 | Formula: C10H12N2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N/C(=C/[N+](=O)[O-])/SC
  • InChi: 1S/C10H12N2O3S/c1-15-9-5-3-8(4-6-9)11-10(16-2)7-12(13)14/h3-7,11H,1-2H3/b10-7-
  • InChiKey: KTGOPTAYWAHLCN-YFHOEESVSA-N  


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Synonyms

  • 4-methoxy-N-[(Z)-1-methylsulfanyl-2-nitroethenyl]aniline
  • 4-methoxy-N-(1-methylsulfanyl-2-nitro-vinyl)aniline
  • 4-methoxy-N-[(Z)-1-methylsulfanyl-2-nitro-vinyl]aniline
  • 4-methoxy-N-[1-(methylthio)-2-nitrovinyl]aniline
  • 4-methoxy-N-[(Z)-1-(methylthio)-2-nitrovinyl]aniline
  • (4-methoxyphenyl)-[1-(methylthio)-2-nitro-vinyl]amine
  • (4-methoxyphenyl)-[(Z)-1-(methylthio)-2-nitro-vinyl]amine
  • 4-methoxy-N-(1-methylsulfanyl-2-nitro-ethenyl)aniline
  • 4-methoxy-N-[(Z)-1-methylsulfanyl-2-nitro-ethenyl]aniline
  • SMR000332990
  • 2B-024
  • ZINC03210023
  • 4-methoxy-N-[1-(methylsulfanyl)-2-nitrovinyl]aniline
  • MLS000694682

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0178 0.4162
Trichomonas vaginalis STE family protein kinase 0.0157 0.0736 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0042 0.0013
Echinococcus granulosus protein kinase shaggy 0.0059 0.0178 0.0154
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0178 0.2419
Trichomonas vaginalis STE family protein kinase 0.0157 0.0736 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0042 0.0983
Echinococcus multilocularis cyclin dependent kinase 5 0.0103 0.0428 0.043
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0152 0.0705 0.147
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0428 0.5812
Trypanosoma cruzi cdc2-related kinase 3 0.0103 0.0428 1
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0086 0.0328 0.0319
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.1175 0.8837
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0042 0.0983
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0178 0.0156
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0063 0.0197 0.4082
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0428 0.0431
Trypanosoma brucei protein kinase, putative 0.0063 0.0197 0.4082
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0257 0.5623
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.0705 0.147
Schistosoma mansoni serine/threonine kinase 0.004 0.0067 0.0067
Echinococcus multilocularis calcium activated potassium channel 0.004 0.0067 0.0034
Echinococcus granulosus PAK box P21 Rho binding 0.0152 0.0705 0.0734
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0103 0.0428 1
Echinococcus multilocularis mitogen activated protein kinase 0.0063 0.0197 0.0177
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0178 0.36
Schistosoma mansoni hypothetical protein 0.0205 0.1005 0.2129
Toxoplasma gondii thioredoxin reductase 0.0103 0.0425 0.9925
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0086 0.0328 0.0319
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.004 0.0067 0.0031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0425 0.2985
Echinococcus multilocularis mitogen activated protein kinase 3 0.0063 0.0197 0.0177
Schistosoma mansoni protein kinase 0.0157 0.0736 0.1538
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0157 0.0736 0.0769
Schistosoma mansoni protein kinase 0.0157 0.0736 0.1538
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0257 0.0485
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4587 0.5001
Brugia malayi MAP kinase sur-1 0.0063 0.0197 0.0161
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4587 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0063 0.0197 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1631 0.9134 1
Trichomonas vaginalis STE family protein kinase 0.0157 0.0736 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0428 0.0429
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1631 0.9134 1
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0067 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0197 0.0353
Trypanosoma cruzi cdc2-related kinase 3 0.0103 0.0428 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0042 0.0983
Brugia malayi Importin beta-1 subunit 0.0035 0.0038 0.0001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0131 0.0095
Entamoeba histolytica protein kinase, putative 0.0059 0.0178 0.2419
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0042 0.0572
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0257 0.0241
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.1175 0.8837
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0197 0.2674
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0257 1
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0131 0.1782
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Brugia malayi P21-Rho-binding domain containing protein 0.0152 0.0705 0.0672
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0157 0.0736 0.0769
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0103 0.0428 0.0393
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0042 0.0116
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0178 0.36
Entamoeba histolytica cell division protein kinase 2, putative 0.0103 0.0428 0.5812
Entamoeba histolytica protein kinase, putative 0.0157 0.0736 1
Plasmodium vivax protein kinase Crk2 0.0103 0.0428 1
Loa Loa (eye worm) glutathione reductase 0.0103 0.0425 0.039
Schistosoma mansoni protein kinase 0.0157 0.0736 0.1538
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.1175 0.8837
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0103 0.0428 1
Schistosoma mansoni hypothetical protein 0.0152 0.0705 0.147
Treponema pallidum NADH oxidase 0.0036 0.0042 0.5
Echinococcus granulosus calcium activated potassium channel 0.004 0.0067 0.0032
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0178 0.36
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0178 0.0142
Trypanosoma brucei cdc2-related kinase 1 0.0103 0.0428 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0178 0.0142
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0152 0.0705 0.0734
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.1175 0.8837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0086 0.0328 0.0321
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0042 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Leishmania major trypanothione reductase 0.0103 0.0425 0.9932
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0042 0.0116
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0152 0.0705 0.0736
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0157 0.0736 0.0769
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0067 0.0905
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0157 0.0736 0.0768
Brugia malayi Protein kinase domain containing protein 0.0103 0.0428 0.0393
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0157 0.0736 0.0768
Entamoeba histolytica cell division protein kinase 2, putative 0.0103 0.0428 0.5812
Echinococcus multilocularis cyclin dependent kinase 0.0103 0.0428 0.043
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0178 0.0156
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0257 0.0485
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0103 0.0428 0.0393
Echinococcus granulosus cyclin dependent kinase 1 0.0103 0.0428 0.0429
Schistosoma mansoni hypothetical protein 0.0152 0.0705 0.147
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0042 0.0116
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0042 0.0116
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0042 0.0983
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0257 1
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0086 0.0328 0.0321
Echinococcus granulosus cyclin dependent kinase 0.0103 0.0428 0.0429
Brugia malayi Protein kinase domain 0.0157 0.0736 0.0702
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0428 0.5812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0257 1
Plasmodium vivax glutathione reductase, putative 0.0103 0.0425 0.9925
Entamoeba histolytica p21-activated kinase 0.0157 0.0736 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0042 0.0116
Trichomonas vaginalis STE family protein kinase 0.0157 0.0736 1
Echinococcus granulosus serine:threonine protein kinase 0.0051 0.0131 0.0103
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0042 0.0116
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0428 0.5812
Echinococcus granulosus cyclin dependent kinase 5 0.0103 0.0428 0.0429
Schistosoma mansoni hypothetical protein 0.0372 0.1957 0.4221
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0042 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.0705 0.9585
Plasmodium falciparum thioredoxin reductase 0.0103 0.0425 0.9925
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0042 0.0572
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Entamoeba histolytica protein kinase, putative 0.0157 0.0736 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0063 0.0197 0.0175
Echinococcus multilocularis PAK box P21 Rho binding 0.0152 0.0705 0.0736
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0178 0.0312
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0042 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0428 0.086
Brugia malayi P21-Rho-binding domain containing protein 0.0152 0.0705 0.0672
Plasmodium falciparum glutathione reductase 0.0103 0.0425 0.9925
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0157 0.0736 0.0768
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0067 0.0067
Giardia lamblia Kinase, CMGC MAPK 0.0063 0.0197 0.223
Schistosoma mansoni importin beta-1 0.0035 0.0038 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.1175 0.8837
Trypanosoma cruzi cdc2-related kinase 1 0.0103 0.0428 1
Entamoeba histolytica hypothetical protein 0.0152 0.0705 0.9585
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0042 0.0116
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0197 0.2674
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0428 0.086
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0103 0.0428 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0178 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0067 0.0067
Brugia malayi cell division control protein 2 homolog 0.0103 0.0428 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0042 0.0983
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.1324 1
Echinococcus multilocularis serine:threonine protein kinase 0.0051 0.0131 0.0104
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0152 0.0705 0.0672
Brugia malayi intracellular kinase 0.0059 0.0178 0.0142
Onchocerca volvulus 0.0059 0.0178 0.5
Brugia malayi glutathione reductase 0.0103 0.0425 0.039
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0197 0.4601
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1957 0.1928
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4587 0.5002
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0178 0.2419
Echinococcus multilocularis snurportin 1 0.0372 0.1957 0.2111
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0038 0.0002
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0063 0.0197 0.4601
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0197 0.4601
Schistosoma mansoni tyrosine kinase 0.0152 0.0705 0.147
Echinococcus granulosus geminin 0.0205 0.1005 0.1064
Giardia lamblia Kinase, STE STE20 0.0157 0.0736 1
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0152 0.0705 0.0734
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0197 0.2674
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0328 0.0642
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0425 0.9925
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0042 0.0007
Brugia malayi Thioredoxin reductase 0.0103 0.0425 0.039
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0042 0.5
Schistosoma mansoni hypothetical protein 0.0152 0.0705 0.147
Echinococcus multilocularis cyclin dependent kinase 1 0.0103 0.0428 0.043
Loa Loa (eye worm) hypothetical protein 0.0152 0.0705 0.0672
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0178 0.1959
Trypanosoma cruzi cdc2-related kinase 1 0.0103 0.0428 1
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0425 0.9932
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0063 0.0197 0.4601
Echinococcus granulosus snurportin 1 0.0372 0.1957 0.211
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0197 0.2674
Trichomonas vaginalis STE family protein kinase 0.0157 0.0736 1
Entamoeba histolytica protein kinase, putative 0.0157 0.0736 1
Plasmodium falciparum thioredoxin reductase 0.0036 0.0042 0.0116
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0042 0.5
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0063 0.0197 0.4601
Entamoeba histolytica hypothetical protein 0.0152 0.0705 0.9585
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0257 0.1676
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0178 0.2419
Schistosoma mansoni hypothetical protein 0.0205 0.1005 0.2129
Mycobacterium tuberculosis Probable reductase 0.0234 0.1175 0.8837
Trypanosoma brucei protein kinase, putative 0.0059 0.0178 0.36
Brugia malayi WH1 domain containing protein 0.0152 0.0705 0.0672
Giardia lamblia Kinase, CMGC CDK 0.0103 0.0428 0.5558
Echinococcus multilocularis PAK box P21 Rho binding 0.0157 0.0736 0.0769
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0257 0.0243
Brugia malayi RNA, U transporter 1 0.0099 0.0403 0.0369
Entamoeba histolytica protein kinase, putative 0.0157 0.0736 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0103 0.0428 0.043
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.1324 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0257 0.6007
Trypanosoma brucei trypanothione reductase 0.0103 0.0425 0.9925
Plasmodium falciparum glutathione reductase 0.0036 0.0042 0.0116
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0042 0.0116
Loa Loa (eye worm) hypothetical protein 0.0098 0.0397 0.0362
Giardia lamblia Kinase, CMGC CDK 0.0103 0.0428 0.5558
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.1324 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0063 0.0197 0.4601
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0063 0.0197 0.4082
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0425 0.039
Echinococcus multilocularis serine:threonine protein kinase 0.0051 0.0131 0.0104
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0103 0.0428 0.0393
Brugia malayi Protein kinase domain containing protein 0.0051 0.0131 0.0095
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0042 0.0116
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0103 0.0428 0.0429
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0042 0.0983
Brugia malayi Protein kinase domain containing protein 0.004 0.0067 0.0031
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0042 0.0006
Trypanosoma brucei cdc2-related kinase 3 0.0103 0.0428 1
Echinococcus multilocularis geminin 0.0205 0.1005 0.1065
Echinococcus granulosus serine:threonine protein kinase 0.0051 0.0131 0.0103
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.1324 1
Plasmodium falciparum protein kinase 5 0.0103 0.0428 1
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0178 0.1959
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0328 0.0642
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0178 0.4162
Schistosoma mansoni protein kinase 0.0152 0.0705 0.147
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0178 0.2419
Echinococcus granulosus mitogen activated protein kinase 0.0063 0.0197 0.0175
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0051 0.0131 0.0095

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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