Detailed information for compound 1398185

Basic information

Technical information
  • TDR Targets ID: 1398185
  • Name: N-[2-(4-methoxyphenyl)ethyl]-3-[4-(trifluorom ethyl)phenyl]-4,5-dihydro-1,2-oxazole-5-carbo xamide
  • MW: 392.372 | Formula: C20H19F3N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCNC(=O)C1ON=C(C1)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C20H19F3N2O3/c1-27-16-8-2-13(3-9-16)10-11-24-19(26)18-12-17(25-28-18)14-4-6-15(7-5-14)20(21,22)23/h2-9,18H,10-12H2,1H3,(H,24,26)
  • InChiKey: FXGNKLWWZYAXOH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-methoxyphenyl)ethyl]-3-[4-(trifluoromethyl)phenyl]-4,5-dihydroisoxazole-5-carboxamide
  • MLS000561180
  • SMR000390824

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis expressed conserved protein 0.0184 0.2196 0.2177
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0127 0.1468 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.0051 0.0473 0.0633
Brugia malayi hypothetical protein 0.0019 0.0069 0.0085
Echinococcus multilocularis notch 0.0027 0.0167 0.0143
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0808 0.1088
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0628 0.4274
Brugia malayi nuclear hormone receptor 0.0018 0.0049 0.0057
Entamoeba histolytica hypothetical protein 0.0071 0.0739 0.2793
Brugia malayi EGF-like domain containing protein 0.0027 0.0167 0.0217
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.002 0.008 1
Brugia malayi Peroxidasin 0.0053 0.0504 0.0675
Schistosoma mansoni hypothetical protein 0.0081 0.0864 0.0946
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0808 0.1088
Echinococcus multilocularis potassium large conductance calcium activated 0.0049 0.0457 0.0434
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0127 0.1468 0.1986
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0049 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0914 0.0892
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Brugia malayi MH2 domain containing protein 0.0121 0.1388 0.1878
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0114 0.1044
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Schistosoma mansoni hypothetical protein 0.0081 0.0864 0.0946
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0049 0.0025
Echinococcus multilocularis fat cadherin tumor suppressor 0.0027 0.0167 0.0143
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0489 0.3327
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0049 0.0057
Echinococcus granulosus neurogenic locus notch protein 4 0.0027 0.0167 0.016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0049 0.0028
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0027 0.0167 0.0853
Echinococcus granulosus potassium large conductance calcium activated 0.0049 0.0457 0.0488
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0808 0.0883
Echinococcus granulosus neurogenic locus protein delta 0.0027 0.0167 0.016
Toxoplasma gondii subtilisin SUB12 0.002 0.0079 0.0141
Echinococcus granulosus mitogen activated protein kinase 11 0.0127 0.1468 0.1627
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0049 0.0028
Onchocerca volvulus 0.002 0.0079 0.0222
Schistosoma mansoni septate junction protein 0.0027 0.0167 0.016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0993 0.0971
Toxoplasma gondii microneme protein MIC17C 0.002 0.0079 0.0141
Plasmodium falciparum cysteine repeat modular protein 1 0.0063 0.0628 1
Echinococcus multilocularis enteropeptidase 0.0019 0.0069 0.0045
Mycobacterium ulcerans hypothetical protein 0.0023 0.0114 0.1044
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0049 0.0057
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0019 0.0069 0.0051
Onchocerca volvulus 0.0019 0.0069 0.0148
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0044
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0079 0.0099
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0489 0.0465
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0599 0.0648
Loa Loa (eye worm) hypothetical protein 0.0107 0.1209 0.1634
Echinococcus granulosus neuropeptide s receptor 0.0476 0.5988 0.6718
Echinococcus multilocularis protein patched 0.0084 0.0903 0.0881
Onchocerca volvulus 0.0023 0.0114 0.0475
Schistosoma mansoni notch 0.0027 0.0167 0.016
Schistosoma mansoni coup transcription factor 0.0018 0.0049 0.0028
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Brugia malayi notch-like transmembrane receptor 0.0027 0.0167 0.0217
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0039 0.024
Echinococcus granulosus delta-like protein 1 0.0027 0.0167 0.016
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0019 0.0069 0.0085
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Brugia malayi EGF-like domain containing protein 0.0027 0.0167 0.0217
Brugia malayi Trypsin family protein 0.0019 0.0069 0.0085
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0438 0.0466
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0808 0.1088
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0045
Onchocerca volvulus 0.002 0.0079 0.0222
Brugia malayi GCC2 and GCC3 family protein 0.0027 0.0167 0.0217
Echinococcus granulosus tar DNA binding protein 0.0076 0.0808 0.0883
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0489 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0085 0.0924 1
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0489 0.0465
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0993 0.1091
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0489 0.3327
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Brugia malayi Blistered cuticle protein 3 0.0053 0.0504 0.0675
Echinococcus granulosus microtubule associated protein 2 0.0701 0.8902 1
Onchocerca volvulus Slit protein homolog 0.0027 0.0167 0.0853
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0099
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Loa Loa (eye worm) hypothetical protein 0.0097 0.107 0.1445
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0049 0.0025
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.0504 0.0675
Onchocerca volvulus 0.0019 0.0069 0.0148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.0167 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0051
Onchocerca volvulus Neurogenic locus notch homolog 0.0027 0.0167 0.0853
Onchocerca volvulus 0.0027 0.0167 0.0853
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Brugia malayi EGF-like domain containing protein 0.0027 0.0167 0.0217
Echinococcus multilocularis neurogenic locus notch protein 4 0.0027 0.0167 0.0143
Toxoplasma gondii PAN domain-containing protein 0.002 0.0079 0.0141
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0024 0.0024
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0903 0.1218
Onchocerca volvulus Putative cubilin 0.0027 0.0167 0.0853
Echinococcus multilocularis tumor protein p63 0.0328 0.406 0.4045
Loa Loa (eye worm) hypothetical protein 0.006 0.0599 0.0805
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.016
Toxoplasma gondii microneme protein MIC17A 0.002 0.0079 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.3436 0.342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0351
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0025 0.0168
Mycobacterium ulcerans hypothetical protein 0.0019 0.0069 0.0544
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0114 0.1044
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0504 0.0675
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Schistosoma mansoni notch 0.0027 0.0167 0.016
Schistosoma mansoni hypothetical protein 0.0069 0.0709 0.0771
Loa Loa (eye worm) hypothetical protein 0.0023 0.0114 0.0146
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0504 0.0675
Leishmania major hypothetical protein, conserved 0.0063 0.0628 0.4274
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0504 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0049 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0024 0.0024
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.0167 0.0143
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.5988 0.5978
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0903 0.099
Onchocerca volvulus 0.0019 0.0069 0.0148
Schistosoma mansoni cell polarity protein 0.0027 0.0167 0.016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0025 0.0024
Echinococcus multilocularis Mastin 0.0019 0.0069 0.0045
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.3436 0.3843
Schistosoma mansoni hypothetical protein 0.0035 0.0265 0.0271
Loa Loa (eye worm) hypothetical protein 0.0023 0.0114 0.0146
Echinococcus granulosus calcium activated potassium channel 0.005 0.047 0.0501
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0223 0.0294
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0504 0.0675
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0489 0.0523
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0903 0.0881
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0903 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.296 0.4013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0114 0.1044
Onchocerca volvulus Peroxidase homolog 0.0053 0.0504 0.3295
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0489 0.0655
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0027 0.0077
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.0167 0.0217
Onchocerca volvulus 0.0063 0.0628 0.4192
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Toxoplasma gondii hypothetical protein 0.002 0.0079 0.0141
Echinococcus multilocularis tissue type plasminogen activator 0.0063 0.0628 0.0605
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0114 0.0779
Onchocerca volvulus 0.0108 0.1214 0.8435
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0049 0.0028
Onchocerca volvulus 0.0048 0.0438 0.2817
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0019 0.0069 0.0045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1388 0.1878
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1388 0.1878
Onchocerca volvulus 0.0067 0.0678 0.456
Onchocerca volvulus 0.0053 0.0504 0.3295
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0049 0.0057
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.2349 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0049 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0993 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0103 0.1148 0.1551
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.1468 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Brugia malayi Trypsin family protein 0.0019 0.0069 0.0085
Onchocerca volvulus 0.002 0.0079 0.0222
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0114 0.1044
Echinococcus multilocularis microtubule associated protein 2 0.0701 0.8902 0.8899
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Echinococcus multilocularis neurogenic locus protein delta 0.0027 0.0167 0.0143
Leishmania major delta-5 fatty acid desaturase 0.0107 0.1209 0.8234
Schistosoma mansoni hypothetical protein 0.0019 0.0069 0.0051
Echinococcus granulosus lamin 0.0027 0.0172 0.0166
Onchocerca volvulus Huntingtin homolog 0.0124 0.143 1
Echinococcus granulosus Mastin 0.0019 0.0069 0.0051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0172 0.0224
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0127 0.1468 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0489 0.4964
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0914 0.1002
Echinococcus multilocularis protein jagged 1 0.0027 0.0167 0.0143
Loa Loa (eye worm) TK/ROR protein kinase 0.0063 0.0628 0.0844
Onchocerca volvulus Dual oxidase homolog 0.0053 0.0504 0.3295
Echinococcus multilocularis peroxidasin 0.0053 0.0504 0.0481
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0126 0.0163
Echinococcus multilocularis jun protein 0.0085 0.0914 0.0892
Echinococcus granulosus peroxidasin 0.0053 0.0504 0.054
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0025 0.0168
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0504 0.3295
Echinococcus multilocularis lamin dm0 0.0027 0.0172 0.0148
Echinococcus multilocularis musashi 0.0027 0.0172 0.0148
Brugia malayi CHE-14 protein 0.0084 0.0903 0.1218
Echinococcus multilocularis protein jagged 1 0.0027 0.0167 0.0143
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0063 0.0628 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0349 0.0366
Brugia malayi hypothetical protein 0.0067 0.0678 0.0913
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0085 0.0924 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.2349 0.3183
Brugia malayi MAP kinase sur-1 0.0052 0.0489 0.0655
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0049 0.0057
Onchocerca volvulus 0.0027 0.0172 0.089
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.0504 0.3295
Echinococcus granulosus transmembrane protease serine 3 0.0019 0.0069 0.0051
Echinococcus multilocularis fibropellin Ia 0.0027 0.0167 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Toxoplasma gondii EGF family domain-containing protein 0.0027 0.0167 0.0366
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0049 0.0025
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.0167 0.0143
Schistosoma mansoni hypothetical protein 0.0081 0.0864 0.0946
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0114 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0099
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0739 0.0805
Schistosoma mansoni hypothetical protein 0.0019 0.0069 0.0051
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0085
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0049 0.0028
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0025 0.0052
Onchocerca volvulus 0.0053 0.0504 0.3295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0049 0.0028
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.2349 0.2331
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0504 0.0675
Loa Loa (eye worm) glutamate receptor 0.0019 0.0067 0.0081
Toxoplasma gondii microneme protein MIC4 0.002 0.0079 0.0141
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0049 0.0057
Schistosoma mansoni peroxidasin 0.0053 0.0504 0.054
Schistosoma mansoni peroxidasin 0.0053 0.0504 0.054
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0049 0.0028
Trypanosoma brucei protein kinase, putative 0.0052 0.0489 0.3213
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0473 0.0633
Schistosoma mansoni neuropeptide receptor 0.0165 0.195 0.217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0993 0.1091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0049 0.0057
Echinococcus granulosus fibropellin Ia 0.0027 0.0167 0.016
Toxoplasma gondii PAN domain-containing protein 0.002 0.0079 0.0141
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Loa Loa (eye worm) glutamate receptor 0.0049 0.0452 0.0605
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0049 0.0028
Echinococcus granulosus protein jagged 2 0.0027 0.0167 0.016
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0489 0.4964
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.016
Echinococcus granulosus geminin 0.0336 0.4176 0.4676
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0019 0.0069 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0993 0.1341
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0489 0.3327
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Entamoeba histolytica hypothetical protein 0.0071 0.0739 0.2793
Loa Loa (eye worm) hypothetical protein 0.0082 0.0884 0.1192
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0044
Onchocerca volvulus 0.0027 0.0167 0.0853
Brugia malayi intermediate filament protein 0.0027 0.0172 0.0224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0993 0.0971
Schistosoma mansoni calcium-activated potassium channel 0.0043 0.0375 0.0395
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0473 0.0633
Echinococcus multilocularis neuropeptide receptor 0.0165 0.195 0.1931
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.1468 0.1448
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0019 0.0069 0.0051
Echinococcus granulosus tumor protein p63 0.0328 0.406 0.4546
Schistosoma mansoni calcium-activated potassium channel 0.0049 0.0457 0.0488
Brugia malayi EGF-like domain containing protein 0.0027 0.0167 0.0217
Echinococcus multilocularis neural cadherin 0.0027 0.0167 0.0143
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.016
Loa Loa (eye worm) RNA binding protein 0.0076 0.0808 0.1088
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0903 0.099
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Onchocerca volvulus 0.0019 0.0069 0.0148
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0051
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0489 0.3213
Toxoplasma gondii microneme protein MIC17B 0.002 0.0079 0.0141
Schistosoma mansoni slit 0.0027 0.0167 0.016
Brugia malayi RNA binding protein 0.0076 0.0808 0.1088
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.1468 0.1448
Onchocerca volvulus 0.002 0.0079 0.0222
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0739 0.0716
Loa Loa (eye worm) DEAH box polypeptide 35 0.0031 0.0223 0.0294
Onchocerca volvulus Peroxidase homolog 0.0053 0.0504 0.3295
Echinococcus granulosus mitogen activated protein kinase 14 0.0127 0.1468 0.1627
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0039 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0063 0.0628 0.0844
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0049 0.0025
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0099 0.1096 1
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Echinococcus multilocularis neurogenic locus protein delta 0.0027 0.0167 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0049 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0993 0.1091
Onchocerca volvulus 0.002 0.0079 0.0222
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0504 0.3295
Toxoplasma gondii kringle domain-containing protein 0.0063 0.0628 0.1556
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0393 0.0524
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Brugia malayi Trypsin family protein 0.0019 0.0069 0.0085
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) Notch2 0.0027 0.0167 0.0217
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0027 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0099
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0504 0.0675
Onchocerca volvulus 0.0027 0.0167 0.0853
Loa Loa (eye worm) hypothetical protein 0.0084 0.0903 0.1218
Schistosoma mansoni fatty acid desaturase 0.0108 0.1214 0.134
Echinococcus granulosus jun protein 0.0085 0.0914 0.1002
Toxoplasma gondii 1,3(4)-beta-glucanase 0.002 0.0079 0.0141
Brugia malayi small heat shock protein 0.0583 0.7365 1
Schistosoma mansoni hypothetical protein 0.0071 0.0739 0.0805
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0808 0.0785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0993 0.1341
Brugia malayi ecdysteroid receptor 0.0018 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0265 0.0351
Brugia malayi EGF-like domain containing protein 0.0027 0.0167 0.0217
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0114 0.0146
Schistosoma mansoni lamin 0.0027 0.0172 0.0166
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0085 0.0924 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0172 0.0166
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0099
Echinococcus granulosus notch 0.0027 0.0167 0.016
Echinococcus granulosus slit 2 protein 0.0027 0.0167 0.016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Entamoeba histolytica hypothetical protein 0.0071 0.0739 0.2793
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0114 0.0779
Loa Loa (eye worm) hypothetical protein 0.0031 0.0215 0.0283
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0049 0.0057
Toxoplasma gondii PAN domain-containing protein 0.0315 0.39 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0049 0.0057
Toxoplasma gondii microneme protein, putative 0.002 0.0079 0.0141
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0539 0.058
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0049 0.0028
Echinococcus multilocularis calcium activated potassium channel 0.005 0.047 0.0446
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0504 0.0675
Brugia malayi follicle stimulating hormone receptor 0.0243 0.296 0.4013
Toxoplasma gondii PAN domain-containing protein 0.002 0.0079 0.0141
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.1468 0.1448
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.2349 0.3183
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0808 0.0883
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0085 0.0924 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0025 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0085
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0049 0.0057
Echinococcus granulosus calcium activated potassium channel variant 0.0043 0.0375 0.0395
Echinococcus granulosus protein jagged 1 0.0027 0.0167 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0114 0.0146
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0489 0.1197
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0349 0.0326
Onchocerca volvulus 0.0027 0.0167 0.0853
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0114 0.1044
Schistosoma mansoni notch 0.0027 0.0167 0.016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0044
Brugia malayi PAN domain containing protein 0.002 0.0079 0.0099
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Brugia malayi Muscle positioning protein 4 0.0027 0.0167 0.0217
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.5988 0.6718
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0049 0.0057
Brugia malayi Cadherin domain containing protein 0.0027 0.0167 0.0217
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0085
Brugia malayi Kringle domain containing protein 0.0063 0.0628 0.0844
Echinococcus granulosus neural cadherin 0.0027 0.0167 0.016
Loa Loa (eye worm) hypothetical protein 0.0124 0.143 0.1933
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0049 0.0057
Onchocerca volvulus 0.002 0.0079 0.0222
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.016
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0599 0.0576
Echinococcus multilocularis geminin 0.0336 0.4176 0.4161
Echinococcus multilocularis protein dispatched 1 0.0096 0.1057 0.1035
Brugia malayi TAR-binding protein 0.0076 0.0808 0.1088
Brugia malayi Protein kinase domain containing protein 0.0063 0.0628 0.0844
Onchocerca volvulus Huntingtin homolog 0.0124 0.143 1
Brugia malayi Trypsin family protein 0.0019 0.0069 0.0085
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0025 0.0024
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.0167 0.016
Brugia malayi hypothetical protein 0.0124 0.143 0.1933
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0049 0.0028
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.1468 0.1448
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0049 0.0057
Toxoplasma gondii PAN/Apple domain-containing protein 0.002 0.0079 0.0141
Echinococcus multilocularis slit 2 protein 0.0027 0.0167 0.0143
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.016
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Brugia malayi bZIP transcription factor family protein 0.0085 0.0914 0.1233
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0808 0.0883
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0126 0.0115
Schistosoma mansoni hypothetical protein 0.0336 0.4176 0.4676
Brugia malayi steroid hormone receptor 0.0018 0.0049 0.0057
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0085
Echinococcus granulosus glycoprotein Antigen 5 0.0019 0.0069 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Toxoplasma gondii hypothetical protein 0.002 0.0079 0.0141
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0049 0.0028
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0027 0.0167 0.016
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0349 0.0366
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0114 0.0779
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0114 0.1044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0027 0.0077
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0489 0.3327
Echinococcus granulosus expressed conserved protein 0.0184 0.2196 0.2446
Echinococcus multilocularis transmembrane protease serine 3 0.0019 0.0069 0.0045
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0049 0.0025
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0039 0.024
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0739 0.0805
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0027 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0489 0.4964
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.2388 0.2663
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0489 0.0523
Schistosoma mansoni lamin 0.0027 0.0172 0.0166
Echinococcus granulosus lamin dm0 0.0027 0.0172 0.0166
Brugia malayi EGF-like domain containing protein 0.0027 0.0167 0.0217
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0049 0.0057
Echinococcus multilocularis calcium activated potassium channel variant 0.0043 0.0375 0.0351
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0049 0.0028
Toxoplasma gondii PAN domain-containing protein 0.0315 0.39 1
Onchocerca volvulus 0.0019 0.0069 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0114 0.1044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0049 0.0057
Brugia malayi P38 map kinase family protein 2 0.0127 0.1468 0.1986
Schistosoma mansoni microtubule-associated protein tau 0.0701 0.8902 1
Onchocerca volvulus 0.0027 0.0172 0.089
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0452 0.0605
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0049 0.0028
Echinococcus multilocularis protein jagged 2 0.0027 0.0167 0.0143
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0051
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0172 0.0224
Onchocerca volvulus 0.002 0.0079 0.0222
Entamoeba histolytica hypothetical protein 0.0071 0.0739 0.2793
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.0167 0.0217
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0049 0.0028
Toxoplasma gondii PAN domain-containing protein 0.002 0.0079 0.0141
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0172 0.0224
Echinococcus granulosus intermediate filament protein 0.0027 0.0172 0.0166
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0504 0.0675
Echinococcus granulosus protein jagged 1 0.0027 0.0167 0.016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0049 0.0025
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Brugia malayi Cadherin domain containing protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.0048 0.0438 0.0586
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0172 0.0224
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0473 0.0633
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0504 0.0675
Onchocerca volvulus 0.002 0.0079 0.0222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0049 0.0028
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0079 0.0099
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0079 0.0099
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.5988 0.5978
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0069 0.0051
Echinococcus granulosus tissue type plasminogen activator 0.0063 0.0628 0.068
Schistosoma mansoni jun-related protein 0.0069 0.0709 0.0771
Loa Loa (eye worm) hypothetical protein 0.0027 0.0165 0.0215
Onchocerca volvulus 0.002 0.0079 0.0222
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0049 0.0057
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.2349 0.2619
Brugia malayi hypothetical protein 0.0053 0.0504 0.0675
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0114 0.1044
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0049 0.0057
Schistosoma mansoni hypothetical protein 0.0063 0.0628 0.068
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.016
Brugia malayi Delta5 fatty acid desaturase 0.0107 0.1209 0.1634
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0583 0.7365 1
Onchocerca volvulus 0.0019 0.0069 0.0148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0049 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0808 0.0883
Echinococcus multilocularis G protein coupled receptor 139 0.0165 0.195 0.1931
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0099
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0069 0.0051
Echinococcus multilocularis glycoprotein Antigen 5 0.0019 0.0069 0.0045
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.1468 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0489 0.3327
Brugia malayi EGF-like domain containing protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0043 0.0375 0.05
Loa Loa (eye worm) hypothetical protein 0.0124 0.143 0.1933
Loa Loa (eye worm) FAT-3 protein 0.0107 0.1209 0.1634
Schistosoma mansoni patched 1 0.0084 0.0903 0.099
Echinococcus granulosus protein jagged 2 0.0027 0.0167 0.016
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0024 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0049 0.0025
Onchocerca volvulus 0.0053 0.0504 0.3295
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0079 0.0099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0993 0.1091
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.0031 0.0215 0.0283
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0114 0.1044
Brugia malayi Trypsin-like protease protein 5 0.0019 0.0069 0.0085
Schistosoma mansoni notch 0.0027 0.0167 0.016
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0031 0.0215 0.0283
Schistosoma mansoni notch 0.0027 0.0167 0.016
Onchocerca volvulus 0.0027 0.0167 0.0853
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0049 0.0025
Loa Loa (eye worm) notch protein 0.0027 0.0167 0.0217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0027 0.0077
Brugia malayi nuclear receptor NHR-88 0.0018 0.0049 0.0057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0489 0.3327
Brugia malayi Delta serrate ligand family protein 0.0027 0.0167 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0049 0.0057
Schistosoma mansoni laminin gamma-3 chain 0.0027 0.0167 0.016
Echinococcus granulosus neuropeptide receptor 0.0165 0.195 0.217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0049 0.0057
Onchocerca volvulus 0.002 0.0079 0.0222
Schistosoma mansoni hypothetical protein 0.0336 0.4176 0.4676
Schistosoma mansoni notch 0.0027 0.0167 0.016
Brugia malayi hypothetical protein 0.0071 0.0739 0.0994
Loa Loa (eye worm) trypsin family protein 0.0019 0.0069 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0808 0.0883
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0114 0.1044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0114 0.1044
Brugia malayi Probable ATP-dependent helicase DHX35 0.0031 0.0223 0.0294
Brugia malayi isocitrate dehydrogenase 0.0016 0.0025 0.0024
Echinococcus multilocularis lamin 0.0027 0.0172 0.0148
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0504 0.0675
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0489 0.0523
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0114 0.0146
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0079 0.0099
Schistosoma mansoni hypothetical protein 0.0081 0.0864 0.0946
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0057
Echinococcus granulosus enteropeptidase 0.0019 0.0069 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0489 0.4964
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0039 0.0212
Onchocerca volvulus 0.002 0.0079 0.0222

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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