Detailed information for compound 1401843

Basic information

Technical information
  • TDR Targets ID: 1401843
  • Name: 5-amino-N-(2,3-dihydro-1,4-benzodioxin-7-yl)- 1-(phenylmethyl)triazole-4-carboxamide
  • MW: 351.359 | Formula: C18H17N5O3
  • H donors: 2 H acceptors: 3 LogP: 2.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nnn(c1N)Cc1ccccc1)Nc1ccc2c(c1)OCCO2
  • InChi: 1S/C18H17N5O3/c19-17-16(21-22-23(17)11-12-4-2-1-3-5-12)18(24)20-13-6-7-14-15(10-13)26-9-8-25-14/h1-7,10H,8-9,11,19H2,(H,20,24)
  • InChiKey: GHCKFQLNHAJLSO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-amino-N-(2,3-dihydro-1,4-benzodioxin-7-yl)-1-(phenylmethyl)-4-triazolecarboxamide
  • 5-amino-1-(benzyl)-N-(2,3-dihydro-1,4-benzodioxin-7-yl)triazole-4-carboxamide
  • 5-amino-N-(2,3-dihydro-1,4-benzodioxin-7-yl)-1-(phenylmethyl)-1,2,3-triazole-4-carboxamide
  • ZINC04852189

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0486 0.1158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0911
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0096 0.023
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0096 0.1711
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.1092 0.2292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0051
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0207 0.0211
Schistosoma mansoni hypothetical protein 0.0041 0.0297 0.0708
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0295 0.0704
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0295 0.0704
Plasmodium falciparum thioredoxin reductase 0.0018 0.0064 0.1547
Leishmania major DNA polymerase kappa, putative 0.0021 0.0096 0.1711
Schistosoma mansoni hypothetical protein 0.002 0.0084 0.0201
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0207 0.504
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0397 0.0405
Trypanosoma brucei unspecified product 0.0021 0.0096 0.1763
Giardia lamblia PHD finger protein 15 0.0032 0.0207 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0509 0.1213
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0096 0.023
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0096 0.0217
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0295 0.6967
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0732 0.1746
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0385 0.0917
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0336 0.08
Entamoeba histolytica hypothetical protein 0.0043 0.032 0.2949
Echinococcus granulosus Transglutaminase 0.0425 0.4195 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0509 0.2274
Trypanosoma brucei ISWI complex protein 0.0015 0.0031 0.0062
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.017 0.0257
Echinococcus multilocularis geminin 0.0188 0.1785 0.1818
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0073 0.0074
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0064 0.0848
Loa Loa (eye worm) hypothetical protein 0.0042 0.0303 0.1345
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0077 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0215 0.0513
Mycobacterium tuberculosis Probable reductase 0.0119 0.1092 0.249
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.1259
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0077 0.0171
Entamoeba histolytica hypothetical protein 0.0043 0.032 0.2949
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.3649
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1066 0.4789
Echinococcus granulosus zinc finger protein 0.0019 0.0074 0.0176
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.0953 0.2272
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0064 0.0906
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0055 0.0223
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0096 0.023
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0077 0.0079
Entamoeba histolytica hypothetical protein 0.0043 0.032 0.2949
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0064 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.1711
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0096 0.2347
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.1228 0.2818
Brugia malayi Thioredoxin family protein 0.0425 0.4195 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0064 0.0152
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.2168
Loa Loa (eye worm) hypothetical protein 0.0119 0.1086 0.488
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0096 0.0217
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0096 0.023
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.017 0.0257
Onchocerca volvulus 0.0033 0.0215 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0473 0.1127
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0173
Loa Loa (eye worm) glutathione reductase 0.0052 0.0411 0.1832
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0064 0.0152
Brugia malayi hypothetical protein 0.0043 0.032 0.0752
Toxoplasma gondii thioredoxin reductase 0.0052 0.0411 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0411 0.098
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0295 0.0704
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0295 0.0704
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0295 0.0704
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0411 0.0419
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.0184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0073 0.0173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.1711
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.032 0.0764
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1066 0.4789
Plasmodium vivax glutathione reductase, putative 0.0052 0.0411 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.017 0.1565
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0295 0.6948
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 0.0257
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.0184
Brugia malayi Bromodomain containing protein 0.0073 0.0625 0.1478
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0411
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0295 0.0704
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0473 0.0481
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0064 0.0065
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.1228 0.2818
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0064 0.0139
Echinococcus granulosus peregrin 0.0035 0.0231 0.055
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0096 0.008
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1105 0.2634
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0096 0.0079
Leishmania major trypanothione reductase 0.0052 0.0411 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0096 0.023
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.1092 0.249
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0215 0.5231
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0297 0.0696
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0077 0.0184
Toxoplasma gondii exonuclease III APE 0.0019 0.0077 0.1878
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0743
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0215 0.0513
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0103 0.0246
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.1092 0.249
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.1092 0.249
Loa Loa (eye worm) hypothetical protein 0.0041 0.0295 0.1308
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0207 0.0494
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0411
Schistosoma mansoni bromodomain containing protein 0.0062 0.0508 0.1212
Brugia malayi CHE-14 protein 0.0051 0.0397 0.0935
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0004 0.001
Onchocerca volvulus Alhambra homolog 0.0032 0.0207 0.0038
Mycobacterium ulcerans hypothetical protein 0.0029 0.017 0.0257
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0295 0.6948
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0173
Brugia malayi Bromodomain containing protein 0.0035 0.0231 0.0538
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0096 0.008
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0295 0.0301
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0509 0.1213
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0397 0.0947
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0096 0.1763
Echinococcus multilocularis expressed conserved protein 0.0112 0.1013 0.1032
Echinococcus multilocularis peregrin 0.0035 0.0231 0.0235
Mycobacterium leprae Conserved hypothetical protein 0.0425 0.4195 1
Trichomonas vaginalis peptide N-glycanase, putative 0.0425 0.4195 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0004 0.0004
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0096 0.0887
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Plasmodium falciparum phd finger protein, putative 0.0032 0.0207 0.504
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.1878
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.1228 0.2818
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0096 0.2347
Loa Loa (eye worm) RNA binding protein 0.0062 0.0509 0.2274
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0077 0.0184
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.982 1
Loa Loa (eye worm) hypothetical protein 0.006 0.049 0.219
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0084 0.0356
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0064 0.1547
Plasmodium falciparum thioredoxin reductase 0.0052 0.0411 1
Brugia malayi jmjC domain containing protein 0.0041 0.0295 0.0691
Echinococcus granulosus dna polymerase kappa 0.0021 0.0096 0.023
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0103 0.0105
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1086 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.1262
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.049 0.1158
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0173
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0096 0.1763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0385 0.0917
Echinococcus multilocularis GPCR, family 2 0.0019 0.0073 0.0074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0077 1
Giardia lamblia Transglutaminase/protease, putative 0.0425 0.4195 1
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0494
Entamoeba histolytica hypothetical protein 0.0043 0.032 0.2949
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0295 0.2718
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0295 0.0692
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0336 0.0342
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0295 0.0704
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0073 0.016
Leishmania major DNA polymerase eta, putative 0.0021 0.0096 0.1711
Schistosoma mansoni zinc finger protein 0.0019 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.1153
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0411
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0096 0.1763
Echinococcus granulosus GPCR family 2 0.0019 0.0073 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0509 0.1213
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1086 0.2589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0051
Echinococcus granulosus tumor protein p63 0.0408 0.4021 0.9586
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0203 0.0483
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.032 0.0764
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Schistosoma mansoni hypothetical protein 0.0049 0.0379 0.0902
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.032 0.0326
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.0953 0.0971
Mycobacterium ulcerans hypothetical protein 0.0425 0.4195 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0073 0.016
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0096 0.041
Echinococcus multilocularis Transglutaminase 0.0425 0.4195 0.4272
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0295 0.6948
Echinococcus multilocularis zinc finger protein 0.0019 0.0074 0.0075
Brugia malayi Thioredoxin reductase 0.0052 0.0411 0.0968
Brugia malayi RNA binding protein 0.0062 0.0509 0.1202
Mycobacterium tuberculosis Long conserved protein 0.0425 0.4195 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0236 0.0241
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0207 0.0911
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0064 0.0906
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0018 0.0029
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0096 0.0098
Loa Loa (eye worm) hypothetical protein 0.0062 0.0514 0.2295
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0096 0.0098
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0064 0.1547
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1086 0.258
Loa Loa (eye worm) hypothetical protein 0.0069 0.0582 0.2605
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 0.0257
Brugia malayi PHD-finger family protein 0.0032 0.0207 0.0481
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0276 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Plasmodium falciparum glutathione reductase 0.0018 0.0064 0.1547
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0411
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0049 0.0116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.1878
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.049 0.219
Brugia malayi Pre-SET motif family protein 0.0231 0.222 0.5286
Schistosoma mansoni zinc finger protein 0.0015 0.0031 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0393
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0295 0.1308
Echinococcus granulosus dna polymerase eta 0.0021 0.0096 0.023
Mycobacterium ulcerans hypothetical protein 0.0425 0.4195 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0077 1
Brugia malayi PHD-finger family protein 0.0024 0.0127 0.029
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0064 0.1547
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0295 0.0704
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0509 0.1213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0393
Mycobacterium ulcerans putative transglutaminase-like protein 0.0425 0.4195 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.017 0.0257
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0077 0.0184
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0743
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0397 0.1769
Brugia malayi TAR-binding protein 0.0062 0.0509 0.1202
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0411 1
Onchocerca volvulus 0.0262 0.2543 0.2414
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0096 0.023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0073 0.0303
Echinococcus granulosus geminin 0.0188 0.1785 0.4255
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0103 0.0246
Brugia malayi Pre-SET motif family protein 0.0033 0.0215 0.05
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0207 0.504
Giardia lamblia Hypothetical protein 0.0425 0.4195 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0385 0.0392
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.017 0.0257
Schistosoma mansoni hypothetical protein 0.0049 0.0379 0.0902
Brugia malayi glutathione reductase 0.0052 0.0411 0.0968
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0397 0.0947
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0077 0.1207
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0295 0.0704
Loa Loa (eye worm) hypothetical protein 0.0051 0.0397 0.1769
Loa Loa (eye worm) hypothetical protein 0.005 0.0385 0.1712
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0096 0.0079
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0077 0.0184
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0411 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0207 0.504
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0303
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.017 0.0257
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0064 0.0906
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0064 0.0906
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0049 0.0116
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0049 0.005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0077 0.0324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0073 0.0173
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0064 0.0848
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.1092 0.249
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0064 0.0848
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.3649
Loa Loa (eye worm) hypothetical protein 0.0041 0.0297 0.1317
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.1228 0.2628
Schistosoma mansoni hypothetical protein 0.0425 0.4195 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0411
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.1711
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0077 0.1207
Trichomonas vaginalis set domain proteins, putative 0.0262 0.2543 0.6063
Echinococcus multilocularis dna polymerase eta 0.0021 0.0096 0.0098
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1604 0.3824
Brugia malayi jmjC domain containing protein 0.0106 0.0953 0.2262
Onchocerca volvulus 0.006 0.0486 0.0321
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0064 0.0152
Mycobacterium ulcerans transglutaminase family protein 0.0425 0.4195 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.047 0.0479
Brugia malayi Bromodomain containing protein 0.0037 0.026 0.0608
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0509 0.0518
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0509 0.1202
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0064 0.1547
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0411 0.1832
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0411 0.0841
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0049 0.0116
Mycobacterium tuberculosis Conserved protein 0.0425 0.4195 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0215 0.0219
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0295 0.0301
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0073 0.0074
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0397 0.0947
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0096 0.1763
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0077 0.0711
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0096 0.1711
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0236 0.0564
Echinococcus multilocularis protein patched 0.0051 0.0397 0.0405
Schistosoma mansoni hypothetical protein 0.0043 0.032 0.0764
Mycobacterium tuberculosis Conserved hypothetical protein 0.0425 0.4195 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0064 0.1547
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 0.0257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0385 0.0917
Trypanosoma brucei trypanothione reductase 0.0052 0.0411 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0064 0.0152
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0295 0.0704
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0509 0.1213
Mycobacterium tuberculosis Conserved hypothetical protein 0.0425 0.4195 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0096 0.1711
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.017 0.1565
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1086 0.1106
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0295 0.0301
Echinococcus granulosus tar DNA binding protein 0.0062 0.0509 0.1213
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0509 0.2274
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.017 0.0257
Brugia malayi MH2 domain containing protein 0.0117 0.1066 0.2531
Schistosoma mansoni hypothetical protein 0.0049 0.0379 0.0902
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.017 0.1565
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0295 0.0704
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0743
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0096 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Mycobacterium tuberculosis Hypothetical protein 0.0425 0.4195 1
Schistosoma mansoni DNA polymerase eta 0.0021 0.0096 0.023
Loa Loa (eye worm) hypothetical protein 0.0055 0.0441 0.1969
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0077 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.3649
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.1092 0.249
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1604 0.1634
Schistosoma mansoni hypothetical protein 0.0049 0.0379 0.0902
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0064 0.0848
Schistosoma mansoni hypothetical protein 0.0188 0.1785 0.4255
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0096 0.1763
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0064 0.0848
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0064 0.0848
Echinococcus granulosus expressed conserved protein 0.0112 0.1013 0.2415
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0556 0.2488
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0064 0.1547
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0085 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.222 1
Plasmodium falciparum glutathione reductase 0.0052 0.0411 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.1207
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0096 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.049 0.1158
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0207 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0295 0.0704
Mycobacterium leprae Conserved hypothetical protein 0.0425 0.4195 1
Schistosoma mansoni hypothetical protein 0.0188 0.1785 0.4255
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.041
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0173
Plasmodium vivax SET domain protein, putative 0.0033 0.0215 0.5231
Schistosoma mansoni patched 1 0.0051 0.0397 0.0947
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0393
Echinococcus multilocularis tumor protein p63 0.0408 0.4021 0.4095

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.5918 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.0131 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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