Detailed information for compound 1413081

Basic information

Technical information
  • TDR Targets ID: 1413081
  • Name: [4-chloro-2-[(2-chloro-4-nitrophenyl)carbamoy l]-6-methylphenyl] acetate
  • MW: 383.183 | Formula: C16H12Cl2N2O5
  • H donors: 1 H acceptors: 4 LogP: 3.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1c(C)cc(cc1C(=O)Nc1ccc(cc1Cl)[N+](=O)[O-])Cl
  • InChi: 1S/C16H12Cl2N2O5/c1-8-5-10(17)6-12(15(8)25-9(2)21)16(22)19-14-4-3-11(20(23)24)7-13(14)18/h3-7H,1-2H3,(H,19,22)
  • InChiKey: SJBCEYUECWKTOR-UHFFFAOYSA-N  


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Synonyms

  • [4-chloro-2-[(2-chloro-4-nitro-phenyl)carbamoyl]-6-methyl-phenyl] acetate
  • acetic acid [4-chloro-2-[[(2-chloro-4-nitrophenyl)amino]-oxomethyl]-6-methylphenyl] ester
  • acetic acid [4-chloro-2-[(2-chloro-4-nitro-phenyl)carbamoyl]-6-methyl-phenyl] ester
  • [4-chloro-2-[(2-chloro-4-nitro-phenyl)carbamoyl]-6-methyl-phenyl] ethanoate
  • Oprea1_647962
  • ZINC04256589
  • 4-chloro-2-{[(2-chloro-4-nitrophenyl)amino]carbonyl}-6-methylphenyl acetate
  • MLS000584141
  • SMR000203304

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0329 0.3071 0.3059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.015 0.0126
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0182 0.0325
Entamoeba histolytica hypothetical protein 0.0061 0.0207 0.0344
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0165 0.1316 0.3223
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.011 0.0739 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0105 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.2956 0.5453
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0203 0.0228
Trypanosoma brucei target of rapamycin kinase 3, putative 0.04 0.3826 0.8395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3648 0.6777
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0104 0.067 0.0648
Toxoplasma gondii target of rapamycin (TOR), putative 0.0383 0.3648 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0311 0.2878 0.5304
Loa Loa (eye worm) phosphatidylinositol 3 0.0877 0.8907 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0203 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.2956 0.5453
Leishmania major phosphatidylinositol 3-kinase, putative 0.0253 0.2261 0.4765
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.011 0.0739 0.1233
Loa Loa (eye worm) phosphatidylinositol 3 0.0151 0.1172 0.1316
Brugia malayi CHE-14 protein 0.0051 0.0105 0.0188
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0212 0.1818 0.3276
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0203 0.0362
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0207 0.0233
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.011 0.0739 0.1318
Loa Loa (eye worm) phosphatidylinositol kinase 0.0061 0.0207 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.015 0.015
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0465 0.4518 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0541 0.5333 0.9495
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2605 0.2587
Echinococcus granulosus tumor protein p63 0.0408 0.3911 0.3902
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0212 0.1818 0.3242
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.3824 0.7112
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0207 0.0233
Schistosoma mansoni hypothetical protein 0.0205 0.1743 0.1745
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0216 0.1866 0.3469
Onchocerca volvulus 0.006 0.0198 0.0165
Echinococcus multilocularis serine protein kinase ATM 0.0149 0.1152 0.1131
Entamoeba histolytica hypothetical protein 0.044 0.4254 0.7968
Plasmodium falciparum phosphatidylinositol 3-kinase 0.011 0.0739 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0061 0.0207 0.0183
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0212 0.1818 0.2983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0279 0.2539 0.4656
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0465 0.4518 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0829 0.1515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.2261 0.4124
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0541 0.5333 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0061 0.0207 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.067 0.1081
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0848 0.0849
Brugia malayi hypothetical protein 0.0148 0.1138 0.2031
Loa Loa (eye worm) hypothetical protein 0.0149 0.1152 0.1294
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8445 0.8441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3648 0.6777
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0149 0.1152 0.1132
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0212 0.1818 0.3276
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.011 0.0739 0.0985
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0829 0.0807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.4518 0.8441
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0436 0.4214 0.7517
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.023 0.2011 0.4184
Loa Loa (eye worm) phosphatidylinositol 3 0.032 0.2975 0.334
Brugia malayi follicle stimulating hormone receptor 0.028 0.2543 0.4536
Brugia malayi MH2 domain containing protein 0.0144 0.1098 0.1959
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0481 0.4688 0.8784
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0061 0.0207 0.0183
Entamoeba histolytica hypothetical protein 0.0061 0.0207 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.3409 0.632
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.044 0.4254 0.7968
Onchocerca volvulus 0.0061 0.0207 0.026
Echinococcus multilocularis geminin 0.0205 0.1743 0.1722
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0105 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0216 0.1866 0.3368
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0329 0.3071 0.3054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.2261 0.4124
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.032 0.2975 0.642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.1152 0.2003
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0367 0.3472 0.3456
Onchocerca volvulus Huntingtin homolog 0.0148 0.1138 1
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0086
Leishmania major phosphatidylinositol 3-kinase, putative 0.011 0.0739 0.1233
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.3824 0.7112
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0978 0.9986 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1098 0.1233
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0149 0.1152 0.1751
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0367 0.3472 0.3461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.015 0.0126
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0567 0.5606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.1152 0.2003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.2261 0.4124
Loa Loa (eye worm) hypothetical protein 0.006 0.0203 0.0228
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.011 0.0739 0.1545
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0061 0.0207 0.0183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0253 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0207 0.0195
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0212 0.1818 0.3736
Loa Loa (eye worm) hypothetical protein 0.0148 0.1138 0.1278
Entamoeba histolytica hypothetical protein 0.0061 0.0207 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.2953 0.5448
Loa Loa (eye worm) hypothetical protein 0.0067 0.0275 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0507 0.0768
Loa Loa (eye worm) hypothetical protein 0.0104 0.067 0.0753
Loa Loa (eye worm) hypothetical protein 0.0367 0.3472 0.3898
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0253 0.2261 0.4765
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0567 0.5606 0.5603
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.011 0.0739 0.1233
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0061 0.0207 0.0207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0567 0.5606 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0567 0.5606 0.5595
Echinococcus multilocularis protein patched 0.0051 0.0105 0.0081
Schistosoma mansoni phosphatidylinositol 4-kinase 0.011 0.0739 0.074
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0162 0.1286 0.2503
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0829 0.1478
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1373 0.1353
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0207 0.0233
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0465 0.4518 0.8465
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0086
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0286 0.2605 0.2925
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.0207 0.0369
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0541 0.5333 1
Schistosoma mansoni hypothetical protein 0.0104 0.067 0.0671
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.011 0.0739 0.074
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0465 0.4518 0.4505
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.3824 0.7112
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0541 0.5333 0.9513
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.011 0.0739 0.1212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0149 0.1152 0.2055
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2543 0.2855
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0149 0.1152 0.2192
Trypanosoma cruzi target of rapamycin kinase 3 0.04 0.3826 0.6704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.2261 0.4124
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.011 0.0739 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.2953 0.5448
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0541 0.5333 0.9495
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.0207 0.0369
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.015 0.0268
Schistosoma mansoni hypothetical protein 0.0058 0.0182 0.0182
Mycobacterium leprae conserved hypothetical protein 0.0061 0.0207 0.5
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0978 0.9986 0.9986
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0191 0.1594 0.3217
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0151 0.1172 0.1787
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0541 0.5333 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0149 0.1152 0.1131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0207 0.0195
Giardia lamblia GTOR 0.0465 0.4518 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3648 0.6777
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0367 0.3472 0.6193
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0829 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.4518 0.8441
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0386 0.3679 0.6836
Entamoeba histolytica hypothetical protein 0.0149 0.1152 0.2125
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1316 0.2316
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0386 0.3679 0.6836
Schistosoma mansoni survival motor neuron protein 0.0058 0.0182 0.0182
Brugia malayi hypothetical protein 0.0286 0.2605 0.4647
Loa Loa (eye worm) phosphatidylinositol 3 0.0465 0.4518 0.5073
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.011 0.0739 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.2715 0.4991
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.011 0.0739 0.1346
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0149 0.1152 0.1154
Schistosoma mansoni hypothetical protein 0.0205 0.1743 0.1745
Loa Loa (eye worm) hypothetical protein 0.0061 0.0207 0.0233
Echinococcus multilocularis 0.0061 0.0207 0.0183
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0061 0.0207 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0507 0.0768
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0541 0.5333 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1138 1
Schistosoma mansoni hypothetical protein 0.0043 0.0024 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.015 0.0126
Loa Loa (eye worm) hypothetical protein 0.0051 0.0105 0.0118
Loa Loa (eye worm) hypothetical protein 0.0175 0.1422 0.1597
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.04 0.3826 0.8395
Entamoeba histolytica protein kinase rad3, putative 0.0149 0.1152 0.2125
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0465 0.4518 0.4525
Toxoplasma gondii FATC domain-containing protein 0.0149 0.1152 0.2747
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.011 0.0739 0.0717
Schistosoma mansoni fkbp-rapamycin associated protein 0.0149 0.1152 0.1154
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8445 0.8456
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.011 0.0739 0.1545
Loa Loa (eye worm) hypothetical protein 0.0119 0.0829 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.2956 0.5453
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.3824 0.7112
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0149 0.1152 0.1751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3648 0.6777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.2956 0.5453
Loa Loa (eye worm) hypothetical protein 0.0089 0.0507 0.0569
Loa Loa (eye worm) hypothetical protein 0.0148 0.1138 0.1278
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0207 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3648 0.6777
Echinococcus multilocularis Zinc finger, PHD finger 0.011 0.0739 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0899 0.1519
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0061 0.0207 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.015 0.015
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0465 0.4518 0.7985
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8445 0.8453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3648 0.6777
Leishmania major hypothetical protein, conserved 0.0156 0.1222 0.2355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.015 0.015
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0978 0.9986 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0105 0.0081
Leishmania major phosphatidylinositol 3-related kinase, putative 0.032 0.2975 0.642
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0266 0.2393 0.4462
Loa Loa (eye worm) hypothetical protein 0.006 0.0198 0.0222
Echinococcus granulosus geminin 0.0205 0.1743 0.1725
Schistosoma mansoni patched 1 0.0051 0.0105 0.0105
Echinococcus multilocularis expressed conserved protein 0.0112 0.0752 0.0729
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.015 0.0169
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.011 0.0739 0.1212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.0207 0.0369
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1373 0.1351
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0061 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0165 0.1316 0.1478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.015 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.2953 0.5448
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0212 0.1818 0.3276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0149 0.1152 0.2055
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0465 0.4518 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0285 0.26 0.555
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2605 0.2591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3648 0.6777
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0104 0.067 0.0648
Schistosoma mansoni hypothetical protein 0.0061 0.0207 0.0207
Echinococcus multilocularis tumor protein p63 0.0408 0.3911 0.3896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.4518 0.8441
Brugia malayi FAT domain containing protein 0.0104 0.067 0.1196
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.3824 0.7112
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.011 0.0739 0.0717
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.011 0.0739 0.0985
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0212 0.1818 0.182
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.011 0.0739 0.1212
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.2975 0.5489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0335 0.3132 0.5789
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0089 0.0507 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0279 0.2539 0.4656
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0567 0.5606 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0061 0.0207 0.0195
Loa Loa (eye worm) hypothetical protein 0.0067 0.0275 0.0309
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0465 0.4518 0.7985
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0061 0.0207 0.0183
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0465 0.4518 0.8465
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0061 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0279 0.2539 0.4656
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.011 0.0739 0.1346
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0465 0.4518 0.4511
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0465 0.4518 1
Onchocerca volvulus 0.0061 0.0207 0.026
Brugia malayi hypothetical protein 0.0043 0.0024 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0465 0.4518 0.806
Echinococcus granulosus expressed conserved protein 0.0112 0.0752 0.073
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1098 0.1233
Echinococcus granulosus serine protein kinase ATM 0.0149 0.1152 0.1132
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0577 0.0685
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0212 0.1818 0.3378
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0207 0.5
Echinococcus multilocularis protein dispatched 1 0.0058 0.0182 0.0158
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0212 0.1818 0.3378
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0062 0.0228 0.0255
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0105 0.0081
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0567 0.5606 0.5614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0335 0.3132 0.5789
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0198 0.0198

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4775 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 0.92 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6611 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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