Detailed information for compound 1422784

Basic information

Technical information
  • TDR Targets ID: 1422784
  • Name: [2-oxo-4-(4-propan-2-ylpyridin-1-ium-1-yl)-1, 3-thiazol-5-ylidene]methanolate
  • MW: 248.301 | Formula: C12H12N2O2S
  • H donors: 1 H acceptors: 2 LogP: 1.99 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1sc(=O)[n-]c1[n+]1ccc(cc1)C(C)C
  • InChi: 1S/C12H12N2O2S/c1-8(2)9-3-5-14(6-4-9)11-10(7-15)17-12(16)13-11/h3-8H,1-2H3
  • InChiKey: BDXWHICFUGOXGI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-[2-oxo-4-(4-propan-2-ylpyridin-1-ium-1-yl)-1,3-thiazol-5-ylidene]methanolate
  • (Z)-[2-oxo-4-(4-propan-2-ylpyridin-1-ium-1-yl)-1,3-thiazol-5-ylidene]methanolate
  • [4-(4-isopropylpyridin-1-ium-1-yl)-2-oxo-thiazol-5-ylidene]methanolate
  • (Z)-[4-(4-isopropylpyridin-1-ium-1-yl)-2-oxo-thiazol-5-ylidene]methanolate
  • (E)-[4-(4-isopropylpyridin-1-ium-1-yl)-2-oxo-thiazol-5-ylidene]methanolate
  • [4-(4-isopropyl-1-pyridin-1-iumyl)-2-oxo-5-thiazolylidene]methanolate
  • (Z)-[4-(4-isopropyl-1-pyridin-1-iumyl)-2-oxo-5-thiazolylidene]methanolate
  • (E)-[4-(4-isopropyl-1-pyridin-1-iumyl)-2-oxo-5-thiazolylidene]methanolate
  • (E)-[4-(4-isopropylpyridin-1-ium-1-yl)-2-keto-thiazol-5-ylidene]methanolate
  • (Z)-[4-(4-isopropylpyridin-1-ium-1-yl)-2-keto-thiazol-5-ylidene]methanolate
  • [4-(4-isopropylpyridin-1-ium-1-yl)-2-keto-thiazol-5-ylidene]methanolate
  • MLS000554638
  • SMR000146755
  • ZINC00553291
  • STOCK3S-53612

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax alanine--tRNA ligase, putative 0.0029 0.0206 0.0855
Wolbachia endosymbiont of Brugia malayi alanyl-tRNA synthetase 0.0029 0.0206 0.0469
Echinococcus granulosus Chromo domain 0.0012 0.0002 0.0002
Leishmania major phosphoglycerate kinase B, cytosolic 0.018 0.2045 0.7461
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0066 0.0659 0.2256
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.003 0.0221 0.0528
Mycobacterium ulcerans lipase LipD 0.0043 0.0385 0.1331
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1071 0.2574
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0385 0.1026
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0916 0.3637
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0207 0.2381 1
Schistosoma mansoni chromobox protein 0.0012 0.0002 0.0002
Brugia malayi beta-lactamase family protein 0.0043 0.0385 0.0836
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0098 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.042 0.1359
Plasmodium vivax developmentally regulated GTP-binding protein 1, putative 0.0028 0.0195 0.0812
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0066 0.0658 0.2253
Brugia malayi seryl-tRNA synthetase, mitochondrial precursor, putative 0.002 0.0099 0.0214
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0659 0.2256
Echinococcus multilocularis protein C ets 2 0.0013 0.001 0.001
Schistosoma mansoni smad 0.0027 0.0179 0.0179
Echinococcus granulosus seryl tRNA synthetase mitochondrial 0.002 0.0099 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0385 0.0922
Plasmodium vivax proline--tRNA ligase, putative 0.005 0.0464 0.1943
Brugia malayi Sars1 protein 0.002 0.0099 0.0214
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.003 0.0221 0.0528
Echinococcus multilocularis ets variant gene 4 0.0013 0.001 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5868 0.5868
Echinococcus granulosus lamin dm0 0.0033 0.0252 0.0252
Trypanosoma cruzi seryl-tRNA synthetase 0.002 0.0099 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0358 0.0857
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.001 0.0022
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.003 0.0221 0.0921
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1071 0.2574
Loa Loa (eye worm) hypothetical protein 0.003 0.0226 0.0492
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0252 0.0548
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3237 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0059 0.0128
Brugia malayi N-terminal motif family protein 0.0191 0.2178 0.4733
Echinococcus multilocularis lamin dm0 0.0033 0.0252 0.0252
Schistosoma mansoni histidyl-tRNA synthetase 0.003 0.0221 0.0221
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0385 0.0836
Echinococcus multilocularis histidyl tRNA synthetase 0.003 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0005
Trypanosoma brucei DNA polymerase eta, putative 0.0086 0.0901 0.3166
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.005 0.0464 0.1524
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0035 0.0286 0.0286
Giardia lamblia Metal-dependent hydrolase related to alanyl-tRNA synthetase 0.0029 0.0206 0.0312
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0059 0.0238
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.003 0.0221 0.061
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0002 0.000000000063326
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.0901 0.3166
Schistosoma mansoni hypothetical protein 0.0179 0.2035 0.2035
Plasmodium vivax proline--tRNA ligase, putative 0.002 0.0099 0.0406
Leishmania major histidyl-tRNA synthetase, putative 0.003 0.0221 0.061
Giardia lamblia DINP protein human, muc B family 0.0066 0.0658 0.1424
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0396 0.1818
Brugia malayi Ets-domain containing protein 0.0087 0.092 0.2
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0002 0.00000000011049
Loa Loa (eye worm) TAR-binding protein 0.0067 0.067 0.1457
Brugia malayi MH2 domain containing protein 0.0027 0.0179 0.0389
Brugia malayi alanyl-tRNA synthetase family protein 0.0029 0.0206 0.0447
Leishmania major hypothetical protein, conserved 0.0027 0.018 0.0455
Trypanosoma cruzi tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative 0.0029 0.0206 0.0552
Echinococcus multilocularis Seryl tRNA Synthetase 0.002 0.0099 0.0099
Brugia malayi Importin beta-1 subunit 0.003 0.0226 0.0492
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0752 0.1806
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.4152 1
Schistosoma mansoni cpg binding protein 0.0037 0.0302 0.0302
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1071 0.2574
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.018 0.2045 0.8317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0669 0.2806
Plasmodium falciparum ribosome-interacting GTPase 1, putative 0.0028 0.0195 0.0812
Toxoplasma gondii phosphoglycerate kinase PGKII 0.018 0.2045 0.8587
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus geminin 0.0179 0.2035 0.2035
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0385 0.1026
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0385 0.0922
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.001 0.001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0022
Trypanosoma brucei tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative 0.0029 0.0206 0.0552
Echinococcus multilocularis geminin 0.0179 0.2035 0.2035
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.005 0.0464 0.1524
Treponema pallidum alanyl-tRNA synthetase 0.0029 0.0206 0.0264
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0826 0.0826
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.002 0.0099 0.0233
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0765 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0436 0.1416
Toxoplasma gondii seryl-tRNA synthetase, cytoplasmic, putative 0.002 0.0099 0.0406
Leishmania major threonyl-tRNA synthetase, putative 0.0235 0.272 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0385 0.1609
Brugia malayi Developmentally regulated GTP-binding protein 1, putative 0.0028 0.0195 0.0424
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Schistosoma mansoni hypothetical protein 0.0052 0.0484 0.0484
Brugia malayi RNA, U transporter 1 0.0087 0.091 0.1978
Echinococcus granulosus snurportin 1 0.0325 0.3815 0.3815
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0574 0.1247
Loa Loa (eye worm) developmentally regulated GTP-binding protein 1 0.0028 0.0195 0.0424
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0002 0.000000000063326
Plasmodium falciparum alanine--tRNA ligase 0.0029 0.0206 0.0855
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0916 0.322
Plasmodium vivax glycine--tRNA ligase, putative 0.005 0.0464 0.1943
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0385 0.0385
Loa Loa (eye worm) histone methyltransferase 0.0012 0 0.0001
Trypanosoma brucei seryl-tRNA synthetase 0.002 0.0099 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0078 0.0074
Schistosoma mansoni hypothetical protein 0.0494 0.5868 0.5868
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0002 0.0005
Plasmodium vivax threonine--tRNA ligase, putative 0.0207 0.2381 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.042 0.0914
Schistosoma mansoni tar DNA-binding protein 0.0067 0.067 0.067
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1071 0.3801
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4152 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0385 0.1026
Giardia lamblia Developmentally regulated GTP-binding protein 1 0.0028 0.0195 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0026 0.0026
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Schistosoma mansoni hypothetical protein 0.0052 0.0484 0.0484
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.001 0.001
Trypanosoma brucei phosphoglycerate kinase, putative 0.0066 0.0659 0.2256
Schistosoma mansoni threonyl-tRNA synthetase 0.0187 0.2137 0.2137
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.005 0.0464 0.0464
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0318 0.0318
Onchocerca volvulus 0.0032 0.0249 0.1145
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0033 0.0252 0.0548
Loa Loa (eye worm) Smad1 0.0027 0.0179 0.0389
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.001 0.001
Schistosoma mansoni developmentally regulated GTP-binding protein 1 (drg 1) 0.0028 0.0195 0.0195
Trypanosoma cruzi tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative 0.0029 0.0206 0.0552
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1954 0.8148
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0002 0.0002
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0235 0.272 0.272
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.018 0.2045 0.8528
Loa Loa (eye worm) hypothetical protein 0.0043 0.0385 0.0836
Loa Loa (eye worm) hypothetical protein 0.018 0.2051 0.4459
Trypanosoma brucei ribosome-interacting GTPase 2, putative 0.0028 0.0195 0.0513
Plasmodium vivax histidine--tRNA ligase, putative 0.003 0.0221 0.0921
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.001 0.0022
Plasmodium vivax unspecified product 0.0028 0.0195 0.0812
Trypanosoma brucei phosphoglycerate kinase 0.0066 0.0659 0.2256
Loa Loa (eye worm) fli-1 protein 0.0265 0.3088 0.6711
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.092 0.092
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0235 0.272 1
Treponema pallidum glycyl-tRNA synthetase 0.003 0.0221 0.0302
Leishmania major glycyl tRNA synthetase, putative 0.003 0.0221 0.061
Loa Loa (eye worm) hypothetical protein 0.005 0.0464 0.1009
Brugia malayi Protein cec-1. 0.0012 0.0002 0.0005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0066 0.0658 0.1887
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.0916 0.2201
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0826 0.1795
Trypanosoma brucei histidyl-tRNA synthetase 0.003 0.0221 0.061
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0916 0.322
Mycobacterium ulcerans hypothetical protein 0.0043 0.0385 0.1331
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0002 0.000000000063326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0574 0.0574
Schistosoma mansoni kinase 0.0051 0.0473 0.0473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.067 0.1457
Echinococcus multilocularis alanyl tRNA synthetase, cytoplasmic 0.0029 0.0206 0.0206
Echinococcus multilocularis phosphoglycerate kinase 1 0.018 0.2045 0.2045
Plasmodium falciparum phosphoglycerate kinase 0.018 0.2045 0.8587
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0831 0.2901
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0098 0.023
Plasmodium vivax serine--tRNA ligase, putative 0.002 0.0099 0.0406
Echinococcus granulosus protein C ets 2 0.0013 0.001 0.001
Echinococcus multilocularis Chromo domain 0.0012 0.0002 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0078 0.0074
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0078 0.0074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0574 0.162
Schistosoma mansoni hypothetical protein 0.0112 0.1213 0.1213
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0318 0.0318
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0078 0.0074
Brugia malayi beta-lactamase family protein 0.0043 0.0385 0.0836
Brugia malayi Phosphoglycerate kinase 0.018 0.2045 0.4444
Toxoplasma gondii GTP-binding protein 0.0028 0.0195 0.0812
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1071 0.2574
Mycobacterium ulcerans GTP pyrophosphokinase RelA 0.0028 0.0195 0.0507
Leishmania major GTP-binding protein, putative 0.0028 0.0195 0.0513
Giardia lamblia Prolyl-tRNA synthetase 0.005 0.0464 0.0948
Mycobacterium ulcerans prolyl-tRNA synthetase 0.005 0.0464 0.1677
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0026 0.0026
Echinococcus multilocularis snurportin 1 0.0325 0.3815 0.3815
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0156 0.0371
Echinococcus granulosus phosphoglycerate kinase 1 0.018 0.2045 0.2045
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.0901 0.1959
Entamoeba histolytica hypothetical protein 0.0025 0.0156 0.0371
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.001 0.001
Echinococcus granulosus chromobox protein 1 0.0074 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0098 0.023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0385 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.1071 0.1071
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0396 0.0949
Toxoplasma gondii tRNA ligase class II core domain (G, H, P, S and T) domain-containing protein 0.002 0.0099 0.0406
Loa Loa (eye worm) hypothetical protein 0.018 0.2045 0.4444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Echinococcus granulosus Seryl tRNA Synthetase 0.002 0.0099 0.0099
Echinococcus multilocularis smad 0.0027 0.0179 0.0179
Echinococcus multilocularis musashi 0.0033 0.0252 0.0252
Plasmodium falciparum proline--tRNA ligase, putative 0.002 0.0099 0.0406
Loa Loa (eye worm) hypothetical protein 0.005 0.0464 0.1009
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0156 0.0371
Trypanosoma brucei unspecified product 0.008 0.0831 0.2901
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0179 0.0179
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.003 0.0221 0.061
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Brugia malayi Muscleblind-like protein 0.018 0.2051 0.4459
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0574 0.0574
Echinococcus granulosus Threonyl tRNA synthetase C 0.0235 0.272 0.272
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0385 0.1331
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Toxoplasma gondii cytosolic tRNA-Ala synthetase 0.0029 0.0206 0.0855
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0156 0.0371
Plasmodium falciparum importin beta, putative 0.003 0.0226 0.0943
Echinococcus multilocularis muscleblind protein 0.018 0.2051 0.2051
Plasmodium falciparum proline--tRNA ligase 0.005 0.0464 0.1943
Trichomonas vaginalis phosphoglycerate kinase, putative 0.018 0.2045 0.4922
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0752 0.1634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.1841 0.4002
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0207 0.2381 0.7306
Entamoeba histolytica alanyl-tRNA synthetase, putative 0.0029 0.0206 0.049
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0574 0.1377
Schistosoma mansoni smad1 5 8 and 0.0027 0.0179 0.0179
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.1071 0.3801
Schistosoma mansoni seryl-tRNA synthetase 0.002 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0191 0.2178 0.4733
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1954 0.7864
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.001 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0574 0.0574
Trypanosoma brucei phosphoglycerate kinase 0.018 0.2045 0.7461
Plasmodium vivax phosphoglycerate kinase, putative 0.018 0.2045 0.8587
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0484 0.0484
Brugia malayi beta-lactamase 0.0043 0.0385 0.0836
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.001 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0385 0.0385
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0002 0.0002
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.005 0.0464 0.0464
Echinococcus multilocularis 39S ribosomal protein L39, mitochondrial 0.0028 0.0195 0.0195
Schistosoma mansoni importin beta-1 0.003 0.0226 0.0226
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.018 0.0746
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0026 0.0057
Leishmania major phosphoglycerate kinase C, glycosomal 0.018 0.2045 0.7461
Schistosoma mansoni alanyl-tRNA synthetase 0.0029 0.0206 0.0206
Schistosoma mansoni developmentally regulated GTP-binding protein 1 (drg 1) 0.0028 0.0195 0.0195
Leishmania major DNA polymerase eta, putative 0.0086 0.0901 0.3166
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0659 0.2256
Brugia malayi CHD4 protein 0.0014 0.0026 0.0057
Loa Loa (eye worm) hypothetical protein 0.018 0.2051 0.4459
Giardia lamblia Phosphoglycerate kinase 0.018 0.2045 0.4827
Echinococcus granulosus alanyl tRNA synthetase cytoplasmic 0.0029 0.0206 0.0206
Loa Loa (eye worm) Sars1 protein 0.002 0.0099 0.0214
Loa Loa (eye worm) seryl-tRNA synthetase 0.002 0.0099 0.0214
Chlamydia trachomatis histidine--tRNA ligase 0.003 0.0221 0.0467
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0385 0.1026
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0659 0.2256
Brugia malayi Hypothetical GTP-binding protein C02F5.3 in chromosome III 0.0028 0.0195 0.0424
Onchocerca volvulus 0.0012 0.0002 0.001
Schistosoma mansoni tar DNA-binding protein 0.0067 0.067 0.067
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0059 0.0059
Trypanosoma brucei phosphoglycerate kinase 0.018 0.2045 0.7461
Mycobacterium ulcerans phosphoglycerate kinase 0.018 0.2045 0.8541
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0059 0.0059
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.001 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0226 0.063
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0026 0.0026
Trichomonas vaginalis developmentally regulated GTP-binding protein, putative 0.0028 0.0195 0.0465
Echinococcus multilocularis Smad4 0.0027 0.0179 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0916 0.322
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0396 0.0949
Echinococcus granulosus alanyl tRNA synthetase mitochondrial 0.0029 0.0206 0.0206
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0078 0.032
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0406 0.1698
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.003 0.0221 0.0528
Brugia malayi MH1 domain containing protein 0.0027 0.0179 0.0389
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0826 0.0826
Plasmodium falciparum GTP-binding protein, putative 0.0028 0.0195 0.0812
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0068 0.0148
Echinococcus granulosus intermediate filament protein 0.0033 0.0252 0.0252
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0358 0.1643
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0179 0.0389
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0752 0.1806
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0179 0.0179
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0002 0.0002
Trichomonas vaginalis phosphoglycerate kinase, putative 0.018 0.2045 0.4922
Brugia malayi hypothetical protein 0.0017 0.0065 0.0141
Trypanosoma cruzi phosphoglycerate kinase, putative 0.018 0.2045 0.7461
Echinococcus granulosus Developmentally regulated GTP binding protein 2 0.0028 0.0195 0.0195
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0659 0.2256
Echinococcus granulosus histidyl tRNA synthetase 0.003 0.0221 0.0221
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0207 0.2381 0.5731
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.1071 0.1071
Schistosoma mansoni tar DNA-binding protein 0.0067 0.067 0.067
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.018 0.0746
Plasmodium vivax serine--tRNA ligase, putative 0.002 0.0099 0.0406
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0385 0.0836
Echinococcus granulosus developmentally regulated gtp binding protein 1 0.0028 0.0195 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0067 0.067 0.067
Chlamydia trachomatis threonine--tRNA ligase 0.0235 0.272 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0385 0.0836
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0098 0.023
Entamoeba histolytica hypothetical protein 0.0012 0.0002 0.000000000063326
Echinococcus granulosus glycyl tRNA synthetase 0.005 0.0464 0.0464
Loa Loa (eye worm) glycyl-tRNA synthetase 0.005 0.0464 0.1009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0278 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1071 0.2574
Schistosoma mansoni phosphoglycerate kinase 0.018 0.2045 0.2045
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.005 0.0464 0.1114
Echinococcus multilocularis alanyl tRNA synthetase, mitochondrial 0.0029 0.0206 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0078 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0916 0.322
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0385 0.1225
Echinococcus multilocularis lamin 0.0033 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0052 0.0484 0.1052
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0574 0.1247
Brugia malayi polk-prov protein 0.0046 0.042 0.0914
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.018 0.2045 0.6249
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0002 0.0005
Treponema pallidum threonyl-tRNA synthetase 0.0207 0.2381 0.563
Schistosoma mansoni seryl-tRNA synthetase 0.002 0.0099 0.0099
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0047 0.0047
Toxoplasma gondii phosphoglycerate kinase PGKI 0.018 0.2045 0.8587
Leishmania major DNA polymerase kappa, putative 0.0066 0.0658 0.2253
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1954 0.5964
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1071 0.1071
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.001 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0098 0.023
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.005 0.0464 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.042 0.1359
Echinococcus multilocularis chromobox protein 2 0.0012 0.0002 0.0002
Plasmodium falciparum threonine--tRNA ligase 0.0207 0.2381 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0385 0.1609
Plasmodium falciparum histidine--tRNA ligase, putative 0.003 0.0221 0.0921
Schistosoma mansoni mitochondrial 39S ribosomal protein L39 0.0028 0.0195 0.0195
Schistosoma mansoni chromobox protein 0.0012 0.0002 0.0002
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.005 0.0464 0.1524
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.005 0.0464 0.1943
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0385 0.0385
Echinococcus multilocularis importin subunit beta 1 0.003 0.0226 0.0226
Brugia malayi Phosphoglycerate kinase 0.0066 0.0659 0.1433
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0005
Echinococcus multilocularis developmentally regulated gtp binding protein 1 0.0028 0.0195 0.0195
Echinococcus granulosus lamin 0.0033 0.0252 0.0252
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.005 0.0464 0.1009
Echinococcus granulosus Smad4 0.0027 0.0179 0.0179
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0156 0.0366
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0047 0.0107
Schistosoma mansoni ets 0.0013 0.001 0.001
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0235 0.272 0.5913
Trypanosoma cruzi alanyl-tRNA synthetase, putative 0.0029 0.0206 0.0552
Plasmodium falciparum serine--tRNA ligase, putative 0.002 0.0099 0.0406
Brugia malayi MH1 domain containing protein 0.0015 0.0034 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0211 0.0504
Echinococcus granulosus cpg binding protein 0.0037 0.0302 0.0302
Leishmania major alanyl-tRNA synthetase, putative 0.0029 0.0206 0.0552
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0826 0.2882
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0358 0.0857
Brugia malayi hypothetical protein 0.0038 0.0318 0.0692
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0078 0.032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0195 0.0424
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Schistosoma mansoni hypothetical protein 0.0179 0.2035 0.2035
Mycobacterium ulcerans glycyl-tRNA synthetase 0.005 0.0464 0.1677
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0436 0.1416
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.092 0.092
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.001 0.001
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0207 0.2381 0.5731
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0078 0.0078
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.1071 0.2574
Schistosoma mansoni hypothetical protein 0.0038 0.0318 0.0318
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.3815 0.8292
Onchocerca volvulus 0.0043 0.0385 0.1767
Schistosoma mansoni hypothetical protein 0.0052 0.0484 0.0484
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.003 0.0221 0.0537
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.0916 0.2201
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0226 0.063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0098 0.023
Trichomonas vaginalis alanyl-tRNA synthetase, putative 0.0029 0.0206 0.049
Entamoeba histolytica seryl-tRNA synthetase, putative 0.002 0.0099 0.0233
Onchocerca volvulus 0.0033 0.0252 0.1157
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0059 0.0238
Onchocerca volvulus 0.0033 0.0252 0.1157
Trypanosoma brucei unspecified product 0.0041 0.0351 0.1097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0002 0.000000000063326
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0078 0.0074
Chlamydia trachomatis phosphoglycerate kinase 0.018 0.2045 0.7423
Schistosoma mansoni DNA polymerase eta 0.0086 0.0901 0.0901
Echinococcus multilocularis chromobox protein 1 0.0074 0.0752 0.0752
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0385 0.0922
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0826 0.2882
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.002 0.0099 0.0233
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.018 0.0455
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0252 0.0548
Loa Loa (eye worm) histidyl-tRNA synthetase 0.003 0.0221 0.0481
Mycobacterium ulcerans seryl-tRNA synthetase 0.002 0.0099 0.0088
Echinococcus granulosus tar DNA binding protein 0.0067 0.067 0.067
Loa Loa (eye worm) alanyl-tRNA synthetase 0.0029 0.0206 0.0447
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0659 0.2256
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.005 0.0464 0.1524
Echinococcus multilocularis Developmentally regulated GTP binding protein 2 0.0028 0.0195 0.0195
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0385 0.0922
Toxoplasma gondii GTP-binding protein, putative 0.0028 0.0195 0.0812
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0916 0.3637
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0484 0.1052
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.092 0.2
Plasmodium vivax GTP-binding protein, putative 0.0028 0.0195 0.0812
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0417 0.0417
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.1841 0.4002
Onchocerca volvulus 0.0043 0.0385 0.1767
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0179 0.0179
Toxoplasma gondii serine--tRNA ligase 0.002 0.0099 0.0406
Giardia lamblia Threonyl-tRNA synthetase 0.0207 0.2381 0.5652
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.018 0.0455
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.067 0.1457
Entamoeba histolytica GTP-binding protein, putative 0.0028 0.0195 0.0465
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0826 0.1985
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0916 0.322
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Brugia malayi hypothetical protein 0.0027 0.018 0.0391
Trypanosoma brucei polo-like protein kinase 0.01 0.1071 0.3801
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0002 0.000000000063326
Mycobacterium tuberculosis Conserved protein 0.0043 0.0385 0.1026
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0179 0.0179
Trypanosoma brucei developmentally regulated GTP-binding protein, putative 0.0028 0.0195 0.0513
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0053 0.0124
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0059 0.0059
Brugia malayi CXXC zinc finger family protein 0.0035 0.0278 0.0604
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0826 0.0826
Schistosoma mansoni cpg binding protein 0.0035 0.0278 0.0278
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.001 0.001
Leishmania major developmentally regulated GTP-binding protein 1, putative 0.0028 0.0195 0.0513
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0002 0.0005
Schistosoma mansoni elf1 0.0013 0.001 0.001
Echinococcus granulosus GPCR family 2 0.0052 0.0484 0.0484
Schistosoma mansoni gabp alpha 0.0087 0.092 0.092
Echinococcus multilocularis tar DNA binding protein 0.0067 0.067 0.067
Leishmania major DNA polymerase eta, putative 0.0045 0.0406 0.1305
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.001
Entamoeba histolytica seryl-tRNA synthetase, putative 0.002 0.0099 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0206 0.049
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5868 0.5868
Brugia malayi Alanyl-tRNA synthetase 0.0029 0.0206 0.0447
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.1841 0.4002
Schistosoma mansoni ets-related 0.0265 0.3088 0.3088
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0207 0.2381 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0078 0.0074
Mycobacterium ulcerans beta-lactamase 0.0043 0.0385 0.1331
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1071 0.2574
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0226 0.0943
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0005
Loa Loa (eye worm) helicase 0.0012 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0086
Mycobacterium tuberculosis Conserved protein 0.0043 0.0385 0.1026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4152 1
Plasmodium falciparum serine--tRNA ligase, putative 0.002 0.0099 0.0406
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.002 0.0099 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0053 0.0124
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0826 0.2882
Brugia malayi RNA binding protein 0.0067 0.067 0.1457
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0658 0.2253
Brugia malayi transcription factor E74 isoform 0.0013 0.001 0.0022
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0059 0.0059
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0385 0.1026
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.005 0.0464 0.1524
Brugia malayi isocitrate dehydrogenase 0.0017 0.0059 0.0128
Leishmania major seryl-tRNA synthetase, putative 0.002 0.0099 0.015
Entamoeba histolytica GTP-binding protein, putative 0.0028 0.0195 0.0465
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0002 0.0002
Brugia malayi Heterochromatin protein 1 0.0074 0.0752 0.1634
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.005 0.0464 0.1114
Echinococcus multilocularis seryl tRNA synthetase, mitochondrial 0.002 0.0099 0.0099
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0001 0.0001
Schistosoma mansoni SET domain protein 0.0035 0.0286 0.0286
Schistosoma mansoni intermediate filament proteins 0.0033 0.0252 0.0252
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0059 0.0128
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0385 0.0922
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0102
Schistosoma mansoni Smad4 0.0027 0.0179 0.0179
Giardia lamblia Developmentally regulated GTP-binding protein 1 0.0028 0.0195 0.0287
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0001 0.0001
Brugia malayi chromobox protein homolog 3 0.0041 0.0358 0.0778
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0059 0.0059
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.005 0.0464 0.0464
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0059 0.0238
Echinococcus multilocularis cpg binding protein 0.0037 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0043 0.0385 0.0836
Schistosoma mansoni histidyl-tRNA synthetase 0.003 0.0221 0.0221
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0059 0.0238
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.001 0.0022
Trypanosoma cruzi developmentally regulated GTP-binding protein, putative 0.0028 0.0195 0.0513
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0112 0.1213 0.2636
Schistosoma mansoni lamin 0.0033 0.0252 0.0252
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.018 0.0746
Trypanosoma cruzi alanyl-tRNA synthetase, putative 0.0029 0.0206 0.0552
Echinococcus granulosus 39S ribosomal protein L39 mitochondrial 0.0028 0.0195 0.0195
Trypanosoma cruzi ribosome-interacting GTPase 2, putative 0.0028 0.0195 0.0513
Leishmania major hypothetical protein, conserved 0.0043 0.0385 0.1225
Entamoeba histolytica hypothetical protein 0.0038 0.0318 0.0762
Brugia malayi intermediate filament protein 0.0033 0.0252 0.0548
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.005 0.0464 0.1009
Schistosoma mansoni glycyl-tRNA synthetase 0.005 0.0464 0.0464
Schistosoma mansoni smad1 5 8 and 0.0027 0.0179 0.0179
Trypanosoma cruzi phosphoglycerate kinase, putative 0.018 0.2045 0.7461
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0026 0.0026
Toxoplasma gondii anticodon binding domain-containing protein 0.003 0.0221 0.0921
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.005 0.0464 0.0464
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0002 0.00000000011049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0245 0.0532
Onchocerca volvulus 0.0028 0.0195 0.0896
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0191 0.2178 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0086 0.0901 0.1959
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0235 0.272 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0098 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0211 0.0504
Brugia malayi Ets-domain containing protein 0.0013 0.001 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0385 0.1026
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0078 0.0074
Giardia lamblia Alanyl-tRNA synthetase 0.0029 0.0206 0.0312
Schistosoma mansoni SET domain protein 0.0014 0.0025 0.0025
Brugia malayi MH2 domain containing protein 0.039 0.4601 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0385 0.1225
Onchocerca volvulus 0.0035 0.0278 0.1275
Echinococcus multilocularis muscleblind protein 1 0.018 0.2051 0.2051
Plasmodium falciparum glycine--tRNA ligase 0.003 0.0221 0.0921
Onchocerca volvulus 0.0014 0.0026 0.0117
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.001 0.001
Onchocerca volvulus 0.0043 0.0385 0.1767
Brugia malayi SET domain containing protein 0.0014 0.0026 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1071 0.2574
Loa Loa (eye worm) beta-lactamase 0.0043 0.0385 0.0836
Trypanosoma brucei unspecified product 0.0041 0.0351 0.1097
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.001 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Trypanosoma cruzi histidyl-tRNA synthetase 0.003 0.0221 0.061
Entamoeba histolytica phosphoglycerate kinase, putative 0.018 0.2045 0.4922
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0002 0.000000000063326
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Giardia lamblia Glycyl-tRNA synthetase 0.005 0.0464 0.0948
Loa Loa (eye worm) MH2 domain-containing protein 0.039 0.4601 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.001 0.001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0059 0.0059
Loa Loa (eye worm) transcription factor SMAD2 0.039 0.4601 1
Echinococcus multilocularis prolyl tRNA synthetase, mitochondrial 0.002 0.0099 0.0099
Plasmodium vivax importin-beta 2, putative 0.003 0.0226 0.0943
Brugia malayi MH1 domain containing protein 0.0015 0.0034 0.0075
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0826 0.1795
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0385 0.1225
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0385 0.1026
Entamoeba histolytica hypothetical protein 0.0038 0.0318 0.0762
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.001
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.005 0.0464 0.1114
Schistosoma mansoni tar DNA-binding protein 0.0067 0.067 0.067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0484 0.0484
Schistosoma mansoni chromobox protein 0.0074 0.0752 0.0752
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0385 0.0385
Loa Loa (eye worm) RNA binding protein 0.0067 0.067 0.1457
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0002 0.00000000011049
Brugia malayi MH2 domain containing protein 0.0027 0.0179 0.0389
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1071 0.3801
Loa Loa (eye worm) hypothetical protein 0.0043 0.0385 0.0836
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.005 0.0464 0.1603
Giardia lamblia Seryl-tRNA synthetase 0.002 0.0099 0.005
Echinococcus multilocularis dna polymerase eta 0.0086 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0027 0.018 0.0391
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0235 0.272 0.5913
Leishmania major importin beta-1 subunit, putative 0.0025 0.0156 0.0366
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0436 0.1416
Treponema pallidum prolyl-tRNA synthetase 0.005 0.0464 0.0902
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0318 0.0318
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0078 0.032
Schistosoma mansoni developmentally regulated GTP-binding protein 2 (drg 2) 0.0028 0.0195 0.0195
Echinococcus multilocularis chromobox protein 1 0.0074 0.0752 0.0752
Brugia malayi glycyl-tRNA synthetase 0.005 0.0464 0.1009
Loa Loa (eye worm) hypothetical protein 0.0075 0.0766 0.1664
Schistosoma mansoni threonyl-tRNA synthetase 0.002 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0325 0.3815 0.3815
Trichomonas vaginalis GTP-binding protein, putative 0.0028 0.0195 0.0465
Trichomonas vaginalis esterase, putative 0.0043 0.0385 0.0922
Echinococcus multilocularis glycyl tRNA synthetase 0.005 0.0464 0.0464
Echinococcus granulosus chromobox protein 1 0.0074 0.0752 0.0752
Giardia lamblia Kinase, PLK 0.01 0.1071 0.2436
Loa Loa (eye worm) hypothetical protein 0.0032 0.0249 0.0542
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.1071 0.2327
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0406 0.1305
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0252 0.0548
Trypanosoma brucei alanyl-tRNA synthetase, putative 0.0029 0.0206 0.0552
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0574 0.0574
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0163 0.0677
Loa Loa (eye worm) hypothetical protein 0.0043 0.0385 0.0836
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0047 0.0047
Echinococcus granulosus Chromobox protein 3 0.0012 0.0002 0.0002
Onchocerca volvulus 0.0012 0.0002 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0916 0.322
Echinococcus granulosus smad 0.0027 0.0179 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0068 0.0148
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4152 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0002 0.0005
Echinococcus granulosus chromobox protein 2 0.0012 0.0002 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0484 0.0484
Brugia malayi Fli-1 protein 0.0265 0.3088 0.6711
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.018 0.0455
Entamoeba histolytica hypothetical protein 0.0038 0.0318 0.0762
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.005 0.0464 0.1009
Echinococcus granulosus prolyl tRNA synthetase mitochondrial 0.002 0.0099 0.0099
Schistosoma mansoni chromobox protein 0.0074 0.0752 0.0752
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0001 0.0001
Loa Loa (eye worm) alanyl-tRNA synthetase 0.0029 0.0206 0.0447
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0005
Echinococcus multilocularis GPCR, family 2 0.0052 0.0484 0.0484
Loa Loa (eye worm) nuclear factor I 0.0015 0.0034 0.0075
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.018 0.0746
Loa Loa (eye worm) hypothetical protein 0.0041 0.0358 0.0778
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0059 0.0059
Mycobacterium tuberculosis Conserved protein 0.0043 0.0385 0.1026
Entamoeba histolytica hypothetical protein 0.0038 0.0318 0.0762
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0916 0.322
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.005 0.0464 0.1009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0179 0.0389
Mycobacterium ulcerans histidyl-tRNA synthetase 0.003 0.0221 0.062
Chlamydia trachomatis proline--tRNA ligase 0.005 0.0464 0.1395
Echinococcus granulosus dna polymerase eta 0.0086 0.0901 0.0901
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0484 0.1052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0484 0.1052
Brugia malayi hypothetical protein 0.0012 0.0002 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0457 0.1096
Leishmania major DNA damage repair protein, putative 0.0018 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0163 0.1841 0.4002
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0826 0.2882
Schistosoma mansoni threonyl-tRNA synthetase-related 0.0028 0.0195 0.0195
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.4152 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0235 0.272 1
Mycobacterium ulcerans alanyl-tRNA synthetase 0.0029 0.0206 0.0553
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.1071 0.2327
Brugia malayi Smad1 0.0027 0.0179 0.0389
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0075
Toxoplasma gondii glycyl-tRNA synthetase 0.005 0.0464 0.1943
Schistosoma mansoni lamin 0.0033 0.0252 0.0252
Chlamydia trachomatis alanine--tRNA ligase 0.0029 0.0206 0.0408
Schistosoma mansoni hypothetical protein 0.0052 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0005
Echinococcus granulosus dna polymerase kappa 0.0087 0.0916 0.0916
Brugia malayi Ets-domain containing protein 0.0087 0.092 0.2
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0002 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0098 0.023
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0035 0.0286 0.0286
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0457 0.1096
Schistosoma mansoni prolyl-tRNA synthetase 0.002 0.0099 0.0099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0484 0.0484
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0417 0.0417
Schistosoma mansoni cpg binding protein 0.0037 0.0302 0.0302
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0385 0.1331
Brugia malayi MH1 domain containing protein 0.0027 0.0179 0.0389
Treponema pallidum phosphoglycerate kinase 0.018 0.2045 0.4801
Plasmodium vivax unspecified product 0.0028 0.0195 0.0812
Echinococcus granulosus importin subunit beta 1 0.003 0.0226 0.0226
Echinococcus multilocularis dna polymerase kappa 0.0087 0.0916 0.0916
Leishmania major DNA polymerase kappa, putative 0.0018 0.0078 0.0074
Echinococcus granulosus muscleblind protein 0.018 0.2051 0.2051
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.1071 0.4916
Schistosoma mansoni phosphoglycerate kinase 0.018 0.2045 0.2045
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0207 0.2381 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.1213 0.2636
Schistosoma mansoni ets-related 0.0013 0.001 0.001
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.005 0.0464 0.1524
Brugia malayi TAR-binding protein 0.0067 0.067 0.1457
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0207 0.2381 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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