Detailed information for compound 1424490

Basic information

Technical information
  • TDR Targets ID: 1424490
  • Name: 6-methoxy-2-piperidin-1-ylquinoline-3-carboni trile
  • MW: 267.326 | Formula: C16H17N3O
  • H donors: 0 H acceptors: 2 LogP: 3.18 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2cc(OC)ccc2nc1N1CCCCC1
  • InChi: 1S/C16H17N3O/c1-20-14-5-6-15-12(10-14)9-13(11-17)16(18-15)19-7-3-2-4-8-19/h5-6,9-10H,2-4,7-8H2,1H3
  • InChiKey: CUPQFMAETQXXEL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 6-methoxy-2-(1-piperidyl)quinoline-3-carbonitrile
  • 6-methoxy-2-(1-piperidyl)-3-quinolinecarbonitrile
  • 6-methoxy-2-piperidino-quinoline-3-carbonitrile
  • Oprea1_292342
  • 6-Methoxy-2-piperidin-1-yl-quinoline-3-carbonitrile
  • MLS000030943
  • ASN 02254583
  • SMR000001678

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens poly(A) binding protein, cytoplasmic 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania donovani polyadenylate-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania braziliensis poly(A)-binding protein 3, putative;with=GeneDB:LmjF25.0080 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania mexicana poly(A)-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis nuclear acid binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Theileria parva polyadenylate binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum hypothetical protein Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense polyadenylate-binding protein 1, putative,PABP1 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum poly(A)-binding protein 3, putative;with=GeneDB:LmjF25.0080 Get druggable targets OG5_126795 All targets in OG5_126795
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Echinococcus multilocularis polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Brugia malayi polyadenylate-binding protein 1 Get druggable targets OG5_126795 All targets in OG5_126795
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum poly(A)-binding protein 2,poly(a) binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania major poly(A)-binding protein 3 Get druggable targets OG5_126795 All targets in OG5_126795
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense poly(A)-binding protein 1,PABP2 Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis poly(A) binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to PolyA Binding Protein Get druggable targets OG5_126795 All targets in OG5_126795
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma cruzi polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum Embryonic polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma congolense polyadenylate-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis RNA-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major poly(A)-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Plasmodium knowlesi polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania donovani poly(A)-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania donovani polyadenylate-binding protein 1, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus polyadenylate binding protein Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii polyadenylate binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis poly(a)-binding protein fabm Get druggable targets OG5_126795 All targets in OG5_126795
Trichomonas vaginalis ribonucleoprotein, chloroplast, putative Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to PolyA Binding Protein Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei polyadenylate-binding protein 2 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei polyadenylate-binding protein 1 Get druggable targets OG5_126795 All targets in OG5_126795
Brugia malayi polyadenylate-binding protein 4 Get druggable targets OG5_126795 All targets in OG5_126795
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium yoelii polyA binding protein-related Get druggable targets OG5_126795 All targets in OG5_126795
Babesia bovis polyadenylate binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis RNA-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis poly(A)-binding protein 2, putative;with=GeneDB:LmjF35.4130,poly(A)-binding protein 2, putative Get druggable targets OG5_126795 All targets in OG5_126795
Plasmodium berghei polyadenylate-binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126795 All targets in OG5_126795
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana poly(a) binding protein, putative Get druggable targets OG5_126795 All targets in OG5_126795
Cryptosporidium parvum poly(a)-binding protein fabm, putative Get druggable targets OG5_126795 All targets in OG5_126795
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0012 0.0028 0.0024
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0112 0.0366
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0434 0.0637
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0112 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.4195
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.017 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0081
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1392 0.5308
Brugia malayi hypothetical protein 0.0052 0.0366 0.0362
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0596
Schistosoma mansoni dep domain containing protein 0.0009 0.0004 0.0005
Brugia malayi hypothetical protein 0.0043 0.0296 0.0293
Trypanosoma brucei Metacaspase-4 0.0053 0.0381 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0037 0.0244 0.0591
Echinococcus granulosus polyadenylate binding protein 0.0011 0.002 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0596
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.017 0.0491
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195
Onchocerca volvulus 0.005 0.035 0.2335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Trypanosoma cruzi metacaspase, putative 0.0053 0.0381 0.1434
Schistosoma mansoni hypothetical protein 0.005 0.035 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Echinococcus multilocularis protein quaking 0.0033 0.0206 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0043 0.0122
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0182 0.0441
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0182 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.012 0.0396
Schistosoma mansoni P2X receptor subunit 0.0151 0.121 0.1776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Echinococcus granulosus p2X purinoceptor 4 0.0151 0.121 0.2934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0031 0.0076
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0112 0.0366
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0028 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0105
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0037 0.0244 0.0808
Echinococcus granulosus caspase 2 0.0103 0.0804 0.1948
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2926 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.017 0.1043
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0112 0.0109
Onchocerca volvulus Cell death protein 3 homolog 0.0103 0.0804 0.5398
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0366 0.1374
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0017
Echinococcus granulosus p2X purinoceptor 4 0.0151 0.121 0.2934
Echinococcus multilocularis caspase 8 0.0053 0.0381 0.0923
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0167
Echinococcus granulosus caspase 3 0.0088 0.0673 0.1632
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0024
Schistosoma mansoni ap endonuclease 0.0023 0.012 0.0176
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0112 0.0366
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0445 0.3708 0.3705
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0307 0.2535 1
Echinococcus multilocularis GPCR, family 2 0.0375 0.3114 0.7551
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.012 0.0116
Schistosoma mansoni hypothetical protein 0.0205 0.1666 0.2445
Brugia malayi N-terminal motif family protein 0.0183 0.1486 0.1483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Echinococcus granulosus hypothetical protein 0.0033 0.0206 0.0499
Schistosoma mansoni caspase-7 (C14 family) 0.0103 0.0804 0.1179
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0112 0.0366
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195
Schistosoma mansoni hypothetical protein 0.0205 0.1666 0.2445
Schistosoma mansoni hypothetical protein 0.0375 0.3114 0.4571
Onchocerca volvulus 0.006 0.0434 0.2907
Echinococcus granulosus tumor protein p63 0.0408 0.3394 0.823
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1392 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0028 0.0069
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0381 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0028 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0485 0.1903
Echinococcus multilocularis caspase 0.0141 0.1127 0.2733
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0037 0.0244 0.024
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0112 0.0366
Loa Loa (eye worm) latrophilin receptor protein 2 0.0375 0.3114 0.3112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0105
Plasmodium vivax metacaspase 1, putative 0.0053 0.0381 0.1434
Leishmania major metacaspase, putative 0.0053 0.0381 0.1434
Trypanosoma brucei metacaspase MCA3 0.0053 0.0381 0.1434
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0028 0.0096
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.001 0.0008 0.0019
Schistosoma mansoni ap endonuclease 0.0023 0.012 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0105
Schistosoma mansoni DNA ligase IV 0.0012 0.0028 0.0041
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0028 0.003
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0113 0.0368
Plasmodium falciparum metacaspase-like protein 0.0053 0.0381 0.1434
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0004 0.0005
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0031 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0307 0.2535 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 0.0307 0.2535 0.6147
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Toxoplasma gondii FATC domain-containing protein 0.003 0.0182 0.0704
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0028
Schistosoma mansoni isocitrate dehydrogenase 0.0037 0.0244 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Loa Loa (eye worm) RNA binding protein 0.0445 0.3708 0.3705
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0112 0.0272
Echinococcus granulosus caspase 8 0.0053 0.0381 0.0923
Trypanosoma cruzi metacaspase, putative 0.0053 0.0381 0.1434
Plasmodium falciparum metacaspase 1 0.0053 0.0381 0.1434
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0028 0.0069
Schistosoma mansoni hypothetical protein 0.0033 0.0206 0.0302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0024
Brugia malayi FAT domain containing protein 0.001 0.0008 0.0004
Echinococcus granulosus GPCR family 2 0.0375 0.3114 0.7551
Brugia malayi DKFZp564C0469 protein 0.0012 0.0028 0.0024
Leishmania major hypothetical protein, conserved 0.0052 0.0366 0.1374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.1043
Loa Loa (eye worm) hypothetical protein 0.0103 0.0804 0.08
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 0.1043
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0012 0.0031 0.0045
Schistosoma mansoni hypothetical protein 0.081 0.6813 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0112 0.0109
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0018 0.0014
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1392 1
Schistosoma mansoni hypothetical protein 0.0043 0.0296 0.0434
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0028 0.0041
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0112 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Giardia lamblia GTOR 0.0022 0.0112 0.0292
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0105
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.017 0.1043
Brugia malayi hypothetical protein 0.005 0.035 0.0346
Trypanosoma cruzi metacaspase, putative 0.0053 0.0381 0.1434
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0112 0.0272
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0112 0.0366
Schistosoma mansoni polyadenylate binding protein 0.0011 0.002 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Schistosoma mansoni hypothetical protein 0.0375 0.3114 0.4571
Brugia malayi RNA binding protein 0.0445 0.3708 0.3705
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.4195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0109 0.0351
Brugia malayi isocitrate dehydrogenase 0.0307 0.2535 0.2532
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.017 0.0491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0031 0.0028
Loa Loa (eye worm) tumor suppressor 0.0388 0.3227 0.3225
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0366 0.1431
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0244 0.0358
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0037 0.0244 0.0358
Echinococcus multilocularis tar DNA binding protein 0.0445 0.3708 0.899
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.012 0.0317
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.4195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0307 0.2535 0.6147
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0005
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0012 0.0031 0.0013
Toxoplasma gondii polyadenylate binding protein, putative 0.0011 0.002 0.0066
Schistosoma mansoni hypothetical protein 0.0375 0.3114 0.4571
Schistosoma mansoni polyadenylate binding protein 0.0011 0.002 0.003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.012 0.4262
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0381 0.0377
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0109 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Trypanosoma brucei calpain, putative 0.0135 0.1075 0.4195
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0307 0.2535 0.6147
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0381 0.1278
Loa Loa (eye worm) TAR-binding protein 0.0445 0.3708 0.3705
Loa Loa (eye worm) hypothetical protein 0.006 0.0434 0.0431
Schistosoma mansoni hypothetical protein 0.001 0.0008 0.0011
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0028 0.0069
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0004 0.0005
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0017 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.081 0.6813 0.6812
Onchocerca volvulus 0.0035 0.0222 0.1471
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.081 0.6813 0.6812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Echinococcus granulosus protein quaking 0.0033 0.0206 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0206 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0381 0.1278
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0167
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0143
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0109 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0307 0.2535 0.3721
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0037 0.0244 0.0591
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0037 0.0244 0.024
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.001 0.0008 0.0019
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0028 0.0024
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0381 0.149
Leishmania major isocitrate dehydrogenase, putative 0.0037 0.0244 0.0888
Schistosoma mansoni P2X receptor subunit 0.0151 0.121 0.1776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0081
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0307 0.2535 0.6147
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0043 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0381 0.149
Onchocerca volvulus 0.0029 0.017 0.1124
Brugia malayi Latrophilin receptor protein 2 0.0375 0.3114 0.3112
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2926 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0112 0.0366
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0167
Brugia malayi polyadenylate-binding protein 1 0.0011 0.002 0.0017
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0028 0.0069
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.012 0.0674
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.012 0.0396
Brugia malayi tumor suppressor. 0.0388 0.3227 0.3225
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0375 0.3114 0.7551
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0167
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.012 0.0317
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0307 0.2535 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0081
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0004 0.0009
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0381 0.0559
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0381 0.1434
Brugia malayi Isocitrate dehydrogenase 0.0307 0.2535 0.2532
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0009
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.1486 1
Trypanosoma brucei metacaspase MCA2 0.0053 0.0381 0.1434
Schistosoma mansoni tar DNA-binding protein 0.0445 0.3708 0.5442
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.1043
Entamoeba histolytica tartrate dehydrogenase, putative 0.0037 0.0244 0.0744
Echinococcus multilocularis caspase 2 0.0103 0.0804 0.1948
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.4195
Echinococcus multilocularis polyadenylate binding protein 0.0011 0.002 0.0049
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0307 0.2535 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.012 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0381 0.1434
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0113 0.0368
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Schistosoma mansoni tar DNA-binding protein 0.0445 0.3708 0.5442
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.1075 0.4195
Toxoplasma gondii isocitrate dehydrogenase 0.0307 0.2535 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0307 0.2535 0.6147
Entamoeba histolytica hypothetical protein 0.0043 0.0296 0.0925
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.0043 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.017 0.0293
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0112 0.0366
Brugia malayi TAR-binding protein 0.0445 0.3708 0.3705
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 0.1043
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2926 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.4195
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0112 0.0366
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0112 0.0165
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4124 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0028 0.0069
Brugia malayi hypothetical protein 0.0033 0.021 0.0207
Echinococcus multilocularis p2X purinoceptor 4 0.0151 0.121 0.2934
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0206 0.0203
Schistosoma mansoni tar DNA-binding protein 0.0445 0.3708 0.5442
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0222 0.0218
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.035 0.0848
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0112 0.0292
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0124 0.03
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0366 0.1374
Mycobacterium ulcerans hypothetical protein 0.0029 0.017 0.1043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.012 0.0396
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.012 0.0384
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0307 0.2535 1
Entamoeba histolytica hypothetical protein 0.0043 0.0296 0.0925
Entamoeba histolytica protein kinase rad3, putative 0.0012 0.0031 0.0013
Brugia malayi Probable isocitrate dehydrogenase 0.0037 0.0244 0.024
Echinococcus multilocularis geminin 0.0205 0.1666 0.4039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1185 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.0122
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0028 0.0024
Brugia malayi hypothetical protein 0.0012 0.0028 0.0024
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.1127 0.1654
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0028 0.0069
Schistosoma mansoni cpg binding protein 0.0037 0.0238 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0081
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0009
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0112 0.0165
Schistosoma mansoni topbp1 0.0012 0.0028 0.0041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0307 0.2535 0.6147
Echinococcus multilocularis p2X purinoceptor 4 0.0151 0.121 0.2934
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1075 0.4195
Echinococcus granulosus p2X purinoceptor 4 0.0151 0.121 0.2934
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0381 0.1278
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0552 0.081
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0307 0.2535 1
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0037 0.0244 0.1582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Brugia malayi topoisomerase 0.0012 0.0028 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Schistosoma mansoni tar DNA-binding protein 0.0445 0.3708 0.5442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0081
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0375 0.3114 0.7551
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0124 0.03
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0375 0.3114 0.7551
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0028 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.012 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0028 0.0069
Schistosoma mansoni hypothetical protein 0.0033 0.0206 0.0302
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0037 0.0244 0.1582
Loa Loa (eye worm) hypothetical protein 0.1185 1 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.3114 0.3112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.012 0.0116
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0112 0.0292
Echinococcus multilocularis nibrin 0.0012 0.0028 0.0067
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0307 0.2535 1
Toxoplasma gondii exonuclease III APE 0.0023 0.012 0.0459
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.012 0.0396
Schistosoma mansoni polyadenylate binding protein 0.0011 0.002 0.003
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.1127 0.2733
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0112 0.0366
Echinococcus multilocularis cpg binding protein 0.0037 0.0238 0.0578
Brugia malayi CXXC zinc finger family protein 0.0035 0.0222 0.0218
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0112 0.043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.012 0.029
Echinococcus multilocularis p2X purinoceptor 4 0.0151 0.121 0.2934
Schistosoma mansoni cpg binding protein 0.0035 0.0222 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0028 0.0069
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0146 0.05
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.017 0.1043
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0004 0.0009
Schistosoma mansoni P2X receptor subunit 0.0151 0.121 0.1776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Loa Loa (eye worm) hypothetical protein 0.0037 0.0244 0.024
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4124 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2926 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0112 0.0366
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0375 0.3114 0.3112
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0381 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0037 0.0244 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0112 0.0272
Trypanosoma cruzi metacaspase, putative 0.0053 0.0381 0.1434
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0004 0.0005
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.1075 0.4195
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.012 0.0396
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0296 0.0434
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0112 0.0366
Schistosoma mansoni cpg binding protein 0.0037 0.0238 0.035
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0182 0.0642
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.012 0.0396
Echinococcus multilocularis tumor protein p63 0.0408 0.3394 0.823
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0381 0.1278
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.017 0.1043
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0167
Trypanosoma brucei hypothetical protein 0.0135 0.1075 0.4195
Schistosoma mansoni hypothetical protein 0.0023 0.0124 0.0182
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0112 0.0109
Brugia malayi Probable isocitrate dehydrogenase 0.0037 0.0244 0.024
Brugia malayi hypothetical protein 0.0033 0.0206 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 0.1043
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0028 0.003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Onchocerca volvulus 0.0012 0.0028 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0182 0.0596
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0381 0.1278
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0028 0.0069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0296 0.0718
Echinococcus multilocularis caspase 3 0.0088 0.0673 0.1632
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0296 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0081
Echinococcus granulosus geminin 0.0205 0.1666 0.4039
Brugia malayi Calcitonin receptor-like protein seb-1 0.1185 1 1
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0037 0.0244 0.0591
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0381 0.149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0024
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0037 0.0244 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0028 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0109 0.0351
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0112 0.0272
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.012 0.029
Loa Loa (eye worm) hypothetical protein 0.005 0.035 0.0346
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.012 0.0087
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0037 0.0244 0.0595
Schistosoma mansoni hypothetical protein 0.0375 0.3114 0.4571
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0182 0.0642
Entamoeba histolytica hypothetical protein 0.0043 0.0296 0.0925
Brugia malayi Cell death protein 3 precursor 0.0103 0.0804 0.08
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.035 0.0848
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0112 0.0109
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0028 0.0069
Schistosoma mansoni topbp1 0.0012 0.0028 0.0041
Echinococcus granulosus nibrin 0.0012 0.0028 0.0067
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0028 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0381 0.1278
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0375 0.3114 0.7551
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0445 0.3708 0.3705
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195
Schistosoma mansoni P2X receptor subunit 0.0151 0.121 0.1776
Schistosoma mansoni hypothetical protein 0.0494 0.4124 0.6054
Schistosoma mansoni tar DNA-binding protein 0.0445 0.3708 0.5442
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.1127 0.2733
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0366 0.1374
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.1127 0.1654
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0009
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0037 0.0244 0.0591
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0366 0.0362
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0031 0.0076
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0028 0.0067
Loa Loa (eye worm) hypothetical protein 0.0183 0.1486 0.1483
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0307 0.2535 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2926 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0307 0.2535 0.2532
Loa Loa (eye worm) hypothetical protein 0.0053 0.0381 0.0377
Echinococcus granulosus cpg binding protein 0.0037 0.0238 0.0578
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.017 0.0491
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0044
Entamoeba histolytica hypothetical protein 0.0043 0.0296 0.0925
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0307 0.2535 1
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0366 0.1374
Echinococcus granulosus tar DNA binding protein 0.0445 0.3708 0.899
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0109 0.0041
Trypanosoma brucei metacaspase 0.0053 0.0381 0.1434
Echinococcus granulosus caspase 0.0141 0.1127 0.2733
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0112 0.0366
Entamoeba histolytica hypothetical protein 0.003 0.0182 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0112 0.0359
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0596
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0037 0.0244 0.024
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0366 0.1374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0105
Echinococcus granulosus serine protein kinase ATM 0.003 0.0182 0.0441
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0381 0.1434
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0182 0.0178
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0028 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0366 0.1374
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1075 0.4195

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.284 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 14.753 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
IC50 (functional) = 18.5 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.7933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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