Detailed information for compound 1426366

Basic information

Technical information
  • TDR Targets ID: 1426366
  • Name: 3-[1-(5-acetylthiophene-2-carbonyl)piperidin- 4-yl]-N-(3-methoxyphenyl)propanamide
  • MW: 414.518 | Formula: C22H26N2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.29 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)CCC1CCN(CC1)C(=O)c1ccc(s1)C(=O)C
  • InChi: 1S/C22H26N2O4S/c1-15(25)19-7-8-20(29-19)22(27)24-12-10-16(11-13-24)6-9-21(26)23-17-4-3-5-18(14-17)28-2/h3-5,7-8,14,16H,6,9-13H2,1-2H3,(H,23,26)
  • InChiKey: OBNZBEYJKWRWKQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[1-(5-acetylthiophene-2-carbonyl)-4-piperidyl]-N-(3-methoxyphenyl)propanamide
  • 3-[1-[(5-acetyl-2-thienyl)-oxomethyl]-4-piperidinyl]-N-(3-methoxyphenyl)propanamide
  • 3-[1-(5-acetylthiophene-2-carbonyl)-4-piperidyl]-N-(3-methoxyphenyl)propionamide
  • 3-[1-(5-ethanoylthiophen-2-yl)carbonylpiperidin-4-yl]-N-(3-methoxyphenyl)propanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128068 All targets in OG5_128068
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Get druggable targets OG5_128068 All targets in OG5_128068
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis acetylornithine aminotransferase, putative Get druggable targets OG5_128068 All targets in OG5_128068
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 437 aa 397 aa 28.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0669 0.2644
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0333 0.2128
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0172 0.0276
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1072 0.1032
Loa Loa (eye worm) hypothetical protein 0.0035 0.1072 0.11
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0653 0.067
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0653 0.414
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0134 0.0215
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.1398 0.168
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2083 0.3337
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0669 0.3993
Schistosoma mansoni hypothetical protein 0.0011 0.0172 0.0276
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.3485 0.4272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1431 0.2362
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.1072 0.1275
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0007 0.0045 0.0072
Schistosoma mansoni ap endonuclease 0.0037 0.1139 0.1825
Echinococcus granulosus cpg binding protein 0.0037 0.1124 0.1855
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1072 0.1032
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0776 0.54
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0776 0.0907
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.2384 0.3819
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0653 0.414
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.335 0.5366
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0333 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.6242 0.6405
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0007 0.0045 0.0072
Leishmania major hypothetical protein, conserved 0.0024 0.0669 0.2667
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0026 0.0734 0.4968
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1431 0.2293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2384 0.3295
Schistosoma mansoni nocturnin 0.0007 0.0045 0.0072
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.2384 0.2904
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0134 0.0215
Echinococcus multilocularis tar DNA binding protein 0.0063 0.2083 0.3337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1082 0.1734
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0333 0.2128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.2128
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0007 0.0045 0.0074
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.1398 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.1139 0.1169
Trichomonas vaginalis esterase, putative 0.0035 0.1072 0.1032
Loa Loa (eye worm) hypothetical protein 0.0036 0.1082 0.111
Brugia malayi Thioredoxin reductase 0.0044 0.1398 0.1434
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.1072 0.1275
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0776 0.5489
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1431 0.1469
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0134 0.0221
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0046
Entamoeba histolytica hypothetical protein 0.0027 0.0776 0.4975
Onchocerca volvulus Huntingtin homolog 0.0143 0.5046 0.5023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1082 0.1734
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.1139 0.8089
Brugia malayi TAR-binding protein 0.0063 0.2083 0.2138
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0045 0.0257
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.39 0.4787
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0333 0.1231
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0653 0.3897
Onchocerca volvulus 0.0035 0.1072 0.1032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.2083 0.2138
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.0734 0.0753
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2083 0.3337
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.1139 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0026 0.0734 0.9051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0212 0.0351
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0046
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.1082 0.1734
Mycobacterium ulcerans beta-lactamase 0.0035 0.1072 0.1187
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.2384 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.1082 0.1786
Trichomonas vaginalis helicase, putative 0.0008 0.0059 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1072 0.6408
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0333 0.1961
Brugia malayi CXXC zinc finger family protein 0.0035 0.1051 0.1078
Toxoplasma gondii ABC1 family protein 0.0035 0.1072 0.4353
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1431 0.2293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2384 0.3295
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0776 0.0711
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0669 0.4612
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.2128
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.1139 0.1099
Onchocerca volvulus 0.0035 0.1072 0.1032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.1072 0.11
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0026 0.0734 0.0644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1072 0.1718
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.1231
Plasmodium falciparum thioredoxin reductase 0.0015 0.0333 0.1961
Onchocerca volvulus 0.0036 0.1082 0.1042
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1072 0.1032
Brugia malayi Pre-SET motif family protein 0.0036 0.1082 0.111
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.1082 0.1734
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Schistosoma mansoni cpg binding protein 0.0037 0.1124 0.1801
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0007 0.0045 0.0072
Mycobacterium ulcerans hypothetical protein 0.0035 0.1072 0.1187
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0333 0.2128
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0333 0.0289
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0184 0.6558 0.6542
Schistosoma mansoni cpg binding protein 0.0037 0.1124 0.1801
Mycobacterium leprae conserved hypothetical protein 0.0035 0.1072 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Brugia malayi hypothetical protein 0.0024 0.0669 0.0686
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0653 0.2576
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0172 0.0284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.1072 0.1275
Echinococcus multilocularis Aminotransferase class III 0.0026 0.0734 0.1175
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0669 0.4249
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0007 0.0045 0.0074
Brugia malayi beta-lactamase 0.0035 0.1072 0.11
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.1139 0.4678
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.2128
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0734 0.0644
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.2404 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.335 0.3437
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0653 0.414
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0183 0.0188
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1051 0.1078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1431 0.2362
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0333 0.2128
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1672 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Trichomonas vaginalis set domain proteins, putative 0.0277 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0333 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.142 0.2274
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Brugia malayi beta-lactamase family protein 0.0035 0.1072 0.11
Toxoplasma gondii exonuclease III APE 0.0037 0.1139 0.4638
Mycobacterium tuberculosis Conserved protein 0.0035 0.1072 0.1275
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1072 0.1032
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0776 0.4631
Onchocerca volvulus 0.0097 0.335 0.332
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.2384 0.3295
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.1072 0.1275
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1072 0.1718
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1672 0.6896
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0734 0.1175
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1072 0.7593
Brugia malayi follicle stimulating hormone receptor 0.027 0.9745 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.1139 1
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0653 0.067
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2083 0.3337
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0333 0.122
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0045 0.0046
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.8761 0.899
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0026 0.0734 0.0644
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.1072 0.1769
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1672 0.1634
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0333 0.122
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0333 0.0533
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.335 0.5366
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.2384 0.9913
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0333 0.0533
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.1139 0.8089
Plasmodium vivax exodeoxyribonuclease III, putative 0.0007 0.0045 0.0257
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.1072 0.7593
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0776 0.6676
Onchocerca volvulus 0.0035 0.1072 0.1032
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0734 0.0644
Leishmania major hypothetical protein, conserved 0.0035 0.1072 0.4391
Loa Loa (eye worm) hypothetical protein 0.0035 0.1072 0.11
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0333 0.0549
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.0014
Trypanosoma brucei trypanothione reductase 0.0044 0.1398 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.1139 0.8089
Schistosoma mansoni cpg binding protein 0.0035 0.1051 0.1684
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.1139 0.7452
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0207 0.0213
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.1139 0.7452
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.1007 0.1661
Mycobacterium ulcerans acetylornithine aminotransferase 0.0026 0.0734 0.0644
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.1072 0.1275
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0776 0.0711
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0184 0.6558 0.8087
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.1139 0.1825
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.1072 0.11
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0212 0.0218
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.0734 0.1175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0059 0.0014
Plasmodium falciparum thioredoxin reductase 0.0044 0.1398 0.9212
Schistosoma mansoni neutral sphingomyelinase 0.0007 0.0045 0.0072
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Echinococcus granulosus ornithine aminotransferase 0.0026 0.0734 0.121
Schistosoma mansoni ap endonuclease 0.0037 0.1139 0.1825
Loa Loa (eye worm) TAR-binding protein 0.0063 0.2083 0.2138
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0045 0.0046
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.0734 0.438
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0333 0.1981
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.0014
Loa Loa (eye worm) hypothetical protein 0.0143 0.5046 0.5178
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.1082 0.4396
Loa Loa (eye worm) hypothetical protein 0.0035 0.1072 0.11
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0653 0.4493
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0026 0.0734 0.2918
Echinococcus granulosus traf and tnf receptor associated protein 0.0007 0.0045 0.0074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.39 0.5437
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1513 1
Leishmania major trypanothione reductase 0.0044 0.1398 0.5784
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.3485 0.4724
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0134 0.0215
Echinococcus multilocularis deoxyribonuclease 1 2 0.0007 0.0045 0.0072
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0333 0.1961
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0026 0.0734 0.0855
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0134 0.0221
Plasmodium falciparum ornithine aminotransferase 0.0026 0.0734 0.4689
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.606 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.1139 0.7452
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.335 0.5527
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0653 0.1077
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0045 0.0046
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.1072 0.1187
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0776 1
Mycobacterium ulcerans lipase LipD 0.0035 0.1072 0.1187
Brugia malayi RNA binding protein 0.0063 0.2083 0.2138
Mycobacterium tuberculosis Conserved protein 0.0035 0.1072 0.1275
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.0014
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0653 0.0611
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1672 0.2759
Echinococcus multilocularis traf and tnf receptor associated protein 0.0007 0.0045 0.0072
Onchocerca volvulus 0.0035 0.1051 0.101
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0007 0.0045 0.0074
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0653 0.1046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1431 0.2293
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.39 0.4787
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0333 0.2128
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Echinococcus granulosus Aminotransferase class III 0.0026 0.0734 0.121
Echinococcus multilocularis synaptojanin 1 0.0007 0.0045 0.0072
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0653 0.1046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0669 0.0686
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0653 0.4493
Echinococcus multilocularis neutral sphingomyelinase 0.0007 0.0045 0.0072
Schistosoma mansoni carbon catabolite repressor protein 0.0007 0.0045 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.1082 0.1734
Echinococcus multilocularis cpg binding protein 0.0037 0.1124 0.1801
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.2536 0.4063
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1672 0.1634
Plasmodium vivax SET domain protein, putative 0.0036 0.1082 0.6468
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.1072 0.1187
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0333 0.1961
Onchocerca volvulus Huntingtin homolog 0.0143 0.5046 0.5023
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0669 0.4612
Mycobacterium tuberculosis Probable aminotransferase 0.0184 0.6558 0.8087
Loa Loa (eye worm) glutathione reductase 0.0044 0.1398 0.1434
Loa Loa (eye worm) hypothetical protein 0.0035 0.1072 0.11
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.2128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1431 0.2293
Loa Loa (eye worm) RNA binding protein 0.0063 0.2083 0.2138
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.6242 1
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0734 0.1175
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.8099 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0333 0.2128
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.39 0.4787
Plasmodium falciparum glutathione reductase 0.0044 0.1398 0.9212
Plasmodium falciparum glutathione reductase 0.0015 0.0333 0.1961
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.1072 0.1275
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.1231
Mycobacterium leprae Probable lipase LipE 0.0035 0.1072 0.0581
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.142 0.2342
Trichomonas vaginalis chaperonin, putative 0.0024 0.0653 0.0611
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.0045 0.0257
Schistosoma mansoni synaptojanin 0.0007 0.0045 0.0072
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.2083 0.2138
Schistosoma mansoni hypothetical protein 0.0007 0.0045 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2083 0.3337
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.1139 0.1359
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0026 0.0734 0.0855
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.1072 0.1718
Loa Loa (eye worm) hypothetical protein 0.0143 0.5046 0.5178
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0669 0.4612
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.0014
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0184 0.6558 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.3485 0.4272
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0776 0.3096
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0653 0.1046
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0333 0.0357
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0776 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.1072 0.11
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0184 0.6558 1
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0026 0.0734 0.0855
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0007 0.0045 0.0072
Brugia malayi beta-lactamase family protein 0.0035 0.1072 0.11
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.2384 0.3819
Echinococcus granulosus tar DNA binding protein 0.0063 0.2083 0.3437
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0776 0.3096
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.2384 0.3934
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.1139 0.1169
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0046
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1513 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.1139 0.1295
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.0045 0.0257
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0333 0.1981
Treponema pallidum NADH oxidase 0.0015 0.0333 0.2631
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0045 0.0046
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.3485 0.4272
Toxoplasma gondii thioredoxin reductase 0.0044 0.1398 0.5733
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0669 0.4249
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.3485 0.4272
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.2384 0.3819
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0212 0.034
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0776 0.4975
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.1139 0.6809
Mycobacterium tuberculosis Conserved protein 0.0035 0.1072 0.1275
Loa Loa (eye worm) hypothetical protein 0.0035 0.1072 0.11
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.2128
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0333 0.0289
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1513 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1431 0.1469
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.9745 1
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.1398 0.8358
Schistosoma mansoni synaptojanin 0.0007 0.0045 0.0072
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.1398 0.1434
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0007 0.0045 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.0014
Loa Loa (eye worm) beta-lactamase 0.0035 0.1072 0.11
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0333 0.2128
Mycobacterium ulcerans hypothetical protein 0.0184 0.6558 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1672 0.6896
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.1072 0.1275
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.1139 0.188
Brugia malayi hypothetical protein 0.0016 0.035 0.0359
Plasmodium vivax glutathione reductase, putative 0.0044 0.1398 0.8358
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.6242 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0059 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1082 0.1734
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0776 0.3123
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.1139 0.1099
Brugia malayi CCR4 0.0007 0.0045 0.0046
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.335 0.3437
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0183 0.0188
Echinococcus granulosus synaptojanin 1 0.0007 0.0045 0.0074
Schistosoma mansoni cript-related 0.0007 0.0045 0.0072
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0045 0.0046
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0653 0.067
Echinococcus granulosus neutral sphingomyelinase 0.0007 0.0045 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.0014
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0653 0.2599
Brugia malayi hypothetical protein 0.0143 0.5046 0.5178
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.3485 0.4272
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2083 0.3337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1431 0.2293
Loa Loa (eye worm) acetyltransferase 0.0175 0.6242 0.6405
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0059 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1072 0.7593
Brugia malayi glutathione reductase 0.0044 0.1398 0.1434
Brugia malayi Pre-SET motif family protein 0.0243 0.8761 0.899
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1072 0.1032
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0026 0.0734 0.0855
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0045 0.0046
Mycobacterium tuberculosis Probable reductase 0.01 0.3485 0.4272
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0333 0.2128
Mycobacterium ulcerans L-lysine aminotransferase 0.0026 0.0734 0.0644
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0653 0.1046

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 0.508 uM PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 1.8888 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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