Detailed information for compound 1436224

Basic information

Technical information
  • TDR Targets ID: 1436224
  • Name: (3-methylcyclohexyl) 4-(4-hydroxy-3-methoxyph enyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidin e-5-carboxylate
  • MW: 374.431 | Formula: C20H26N2O5
  • H donors: 3 H acceptors: 3 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1O)C1NC(=O)NC(=C1C(=O)OC1CCCC(C1)C)C
  • InChi: 1S/C20H26N2O5/c1-11-5-4-6-14(9-11)27-19(24)17-12(2)21-20(25)22-18(17)13-7-8-15(23)16(10-13)26-3/h7-8,10-11,14,18,23H,4-6,9H2,1-3H3,(H2,21,22,25)
  • InChiKey: WQANRCGOBKNGNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3-methylcyclohexyl) 4-(4-hydroxy-3-methoxy-phenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
  • 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (3-methylcyclohexyl) ester
  • 4-(4-hydroxy-3-methoxy-phenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (3-methylcyclohexyl) ester
  • MLS000106951
  • SMR000111326
  • UNM000000510401
  • Oprea1_611014
  • BAS 00316418
  • EU-0001883
  • Oprea1_846965

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0518 0.2468 0.423
Loa Loa (eye worm) hypothetical protein 0.018 0.0764 0.1608
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0757 0.367 0.367
Brugia malayi jmjC domain containing protein 0.0065 0.0189 0.0189
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0463 0.2189 0.3716
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0094 0.0105
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0034 0.0033 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0158 0.0658 0.0654
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0037 0.005
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0128 0.0505 0.0505
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0283 0.1286 0.1282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0602 0.2889 0.4921
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0179 0.0763 0.1258
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0772 0.1274
Loa Loa (eye worm) PHD-finger family protein 0.0172 0.0727 0.153
Onchocerca volvulus Glucosylceramidase homolog 0.0119 0.0459 0.1873
Trichomonas vaginalis set domain proteins, putative 0.0483 0.2291 0.3892
Loa Loa (eye worm) hypothetical protein 0.0384 0.1792 0.3786
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.007 0.0509
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.007 0.0214 0.0214
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0904 0.4406 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0757 0.367 0.3667
Schistosoma mansoni cpg binding protein 0.0053 0.0128 0.0128
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0037 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0158 0.0658 0.1271
Entamoeba histolytica Ran family GTPase 0.0042 0.007 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.0958 0.1594
Toxoplasma gondii LsmAD domain-containing protein 0.0067 0.0199 0.0496
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.003 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0094 0.0105
Echinococcus multilocularis Zinc finger, PHD finger 0.0179 0.0763 0.0763
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0246 0.0246
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0094 0.0105
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0128 0.0505 0.1415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0602 0.2889 0.4921
Leishmania major cathepsin L-like protease 0.0046 0.0093 0.02
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0065 0.0189 0.0468
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0144
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0025 0.002
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0034 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0097 0.0092
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0128 0.0505 0.0505
Echinococcus multilocularis PHD finger protein rhinoceros 0.0172 0.0727 0.0727
Echinococcus granulosus importin subunit beta 1 0.0056 0.0145 0.0145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0622 0.2992 0.2992
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0178 0.0756 0.159
Echinococcus granulosus Chromobox protein 3 0.0035 0.0037 0.0037
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0056 0.0144 0.0317
Trypanosoma cruzi target of rapamycin kinase 3 0.071 0.343 0.3427
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0067 0.0199 0.0194
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 0.0377 0.0377
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.0491 0.079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0094 0.0105
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0128 0.0505 0.1415
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0047 0.0097 0.0208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0346 0.1602 0.1602
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.0491 0.079
Echinococcus multilocularis chromobox protein 2 0.0035 0.0037 0.0037
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0128 0.0505 0.0865
Loa Loa (eye worm) fli-1 protein 0.0149 0.0612 0.1286
Trypanosoma cruzi protein farnesyltransferase, putative 0.0126 0.0494 0.0489
Schistosoma mansoni ran 0.0042 0.007 0.007
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0757 0.367 0.367
Plasmodium falciparum importin beta, putative 0.0056 0.0145 0.1529
Brugia malayi Pre-SET motif family protein 0.0062 0.0172 0.0172
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0505 0.1059
Echinococcus granulosus beta LACTamase domain containing family member 0.0158 0.0658 0.0658
Echinococcus granulosus microtubule associated protein 2 0.069 0.333 0.333
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0158 0.0658 0.1384
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.018 0.0769 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.06 0.2878 0.2878
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0047 0.0097 0.0208
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.007 0.007
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0097 0.0208
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.0459 0.0734
Mycobacterium tuberculosis Conserved protein 0.0158 0.0658 0.1271
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0047 0.0097 0.0092
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0126 0.0494 0.0795
Brugia malayi M-phase phosphoprotein, mpp8 0.0035 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0602 0.2889 0.4921
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0128 0.0505 0.0505
Giardia lamblia Phosphatidylinositol 4-kinase 0.0128 0.0505 0.0813
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Echinococcus granulosus dnaJ subfamily B 0.0287 0.1304 0.1304
Echinococcus multilocularis chromobox protein 1 0.0213 0.0933 0.0933
Schistosoma mansoni chromobox protein 0.0035 0.0037 0.0037
Leishmania major cathepsin L-like protease 0.0046 0.0093 0.02
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0126 0.0494 0.0795
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0092 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0346 0.1602 0.2704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.3369 0.5749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Schistosoma mansoni hypothetical protein 0.0057 0.0147 0.0147
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0037 0.0037
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0035 0.0037 0.0037
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0126 0.0494 0.0494
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.012 0.015
Echinococcus multilocularis chromobox protein 1 0.0213 0.0933 0.0933
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0622 0.2992 0.2988
Trichomonas vaginalis chromobox protein, putative 0.0213 0.0933 0.155
Trichomonas vaginalis hypothetical protein 0.0035 0.0037 0.0006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0412 0.0925
Schistosoma mansoni microtubule-associated protein tau 0.069 0.333 0.333
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0958 0.1594
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0067
Trichomonas vaginalis esterase, putative 0.0158 0.0658 0.1078
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.058 0.278 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0145 0.0298
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.018 0.0769 0.1268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0491 0.2333 0.3963
Mycobacterium ulcerans aldehyde dehydrogenase 0.0101 0.0367 0.1305
Loa Loa (eye worm) hypothetical protein 0.0123 0.0479 0.1005
Loa Loa (eye worm) CHromoDomain protein family member 0.0038 0.0051 0.0098
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0128 0.0505 0.6418
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0067
Plasmodium vivax hypothetical protein, conserved 0.0059 0.016 0.1722
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0097 0.0092
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0643 0.1351
Onchocerca volvulus 0.0097 0.0348 0.138
Loa Loa (eye worm) hypothetical protein 0.0302 0.1379 0.291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Leishmania major hypothetical protein, conserved 0.0158 0.0658 0.1485
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0763 0.0758
Mycobacterium ulcerans hypothetical protein 0.0158 0.0658 0.2355
Schistosoma mansoni chromobox protein 0.0035 0.0037 0.0037
Schistosoma mansoni ets-related 0.0149 0.0612 0.0612
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0126 0.0494 0.0795
Mycobacterium ulcerans hypothetical protein 0.0122 0.0474 0.1692
Trichomonas vaginalis penicillin-binding protein, putative 0.0158 0.0658 0.1078
Trichomonas vaginalis conserved hypothetical protein 0.0256 0.1148 0.1922
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0179 0.0763 0.2188
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0097 0.0348 0.0348
Echinococcus multilocularis beta LACTamase domain containing family member 0.0158 0.0658 0.0658
Mycobacterium tuberculosis Probable lipase LipE 0.0158 0.0658 0.1271
Loa Loa (eye worm) hypothetical protein 0.0305 0.1394 0.2942
Echinococcus multilocularis jumonji domain containing 1A 0.0065 0.0189 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.3369 0.5749
Loa Loa (eye worm) jmjC domain-containing protein 0.0247 0.1105 0.233
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0047 0.0097 0.0097
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0047 0.0097 0.0864
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0172 0.0727 0.0727
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0294 0.1338 0.2824
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2016 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0158 0.0658 0.0658
Trichomonas vaginalis chromobox protein, putative 0.0128 0.0507 0.0818
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0145 0.0319
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.007 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0462 0.0739
Echinococcus multilocularis 0.0128 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0094 0.0332 0.0693
Echinococcus granulosus jumonji domain containing protein 0.024 0.1066 0.1066
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1071 0.5248 0.5248
Loa Loa (eye worm) hypothetical protein 0.018 0.0769 0.1618
Brugia malayi Ets-domain containing protein 0.0049 0.0109 0.0109
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0057 0.0147 0.0147
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0128 0.0505 0.0505
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0037 0.0006
Trypanosoma brucei PAB1-binding protein , putative 0.0067 0.0199 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0283 0.1286 0.216
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0057 0.0147 0.0147
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0603 0.2894 0.6121
Loa Loa (eye worm) hypothetical protein 0.0158 0.0658 0.1384
Schistosoma mansoni jumonji/arid domain-containing protein 0.0247 0.1105 0.1105
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0189 0.0184
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0346 0.1602 0.1602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0658 0.1384
Loa Loa (eye worm) helicase 0.0035 0.0037 0.0067
Trypanosoma cruzi lanosterol synthase, putative 0.0034 0.0033 0.0028
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0128 0.0505 0.0813
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0181 0.0772 0.1625
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0128 0.0507 0.2088
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.0459 0.0734
Echinococcus multilocularis snurportin 1 0.0603 0.2894 0.2894
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0145 0.0337
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0134 0.0533 0.0862
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0126 0.0494 0.627
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0093 0.0088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1154 0.5666 0.5666
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0179 0.0763 0.0763
Onchocerca volvulus 0.0035 0.0037 0.000000056762
Brugia malayi hypothetical protein 0.0067 0.0199 0.0199
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0145 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0158 0.0658 0.8502
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Toxoplasma gondii hypothetical protein 0.0047 0.0097 0.019
Mycobacterium leprae conserved hypothetical protein 0.0158 0.0658 0.0674
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0128 0.0505 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.2082 0.3531
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0384 0.1792 0.5273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.1286 0.1286
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0037 0.0006
Echinococcus multilocularis lysine specific demethylase 5A 0.0244 0.109 0.109
Echinococcus granulosus chromobox protein 1 0.0213 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0057 0.0147 0.0302
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0717 0.0717
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1071 0.5248 0.5248
Brugia malayi jmjC domain containing protein 0.0065 0.0189 0.0189
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0092 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0505 0.0813
Entamoeba histolytica protein kinase rad3, putative 0.0346 0.1602 0.2745
Schistosoma mansoni hypothetical protein 0.0603 0.2894 0.2894
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0622 0.2992 0.5099
Brugia malayi CHD4 protein 0.0038 0.0051 0.0051
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0179 0.0763 0.0763
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0346 0.1602 0.1602
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0061 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0772 0.1274
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0057 0.0147 0.0147
Giardia lamblia PHD finger protein 15 0.0172 0.0727 0.1196
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0093 0.0088
Schistosoma mansoni importin beta-1 0.0056 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.1002 0.4898 0.4898
Plasmodium falciparum ataxin-2 like protein, putative 0.0067 0.0199 0.2251
Toxoplasma gondii PHD-finger domain-containing protein 0.0056 0.0144 0.0334
Plasmodium falciparum ataxin-2 like protein, putative 0.0067 0.0199 0.2251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.3369 0.5749
Brugia malayi Associated with TFs and helicases family protein 0.0035 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.3429 0.5854
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0099 0.0169
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0432 0.2032 0.4607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.3429 0.5854
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0346 0.1602 0.1598
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0189 0.0189
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0126 0.0494 0.0795
Schistosoma mansoni hypothetical protein 0.0172 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0067
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.0346 0.1602 0.3383
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0099 0.0113
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0067 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0505 0.0813
Onchocerca volvulus 0.0103 0.0377 0.1511
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0359 0.1666 0.2814
Onchocerca volvulus 0.0128 0.0505 0.2077
Schistosoma mansoni cpg binding protein 0.005 0.0113 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.3429 0.5854
Schistosoma mansoni phosphatidylserine receptor 0.0065 0.0189 0.0189
Giardia lamblia Rab geranylgeranyltransferase 0.018 0.0769 0.1268
Schistosoma mansoni cpg binding protein 0.0053 0.0128 0.0128
Echinococcus granulosus PHD finger protein rhinoceros 0.0172 0.0727 0.0727
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0178 0.0756 0.0756
Echinococcus granulosus tar DNA binding protein 0.0076 0.0246 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.3429 0.5854
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0092 0.0101
Loa Loa (eye worm) hypothetical protein 0.0034 0.0033 0.006
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0128 0.0505 0.0813
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0126 0.0494 0.1382
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0067
Onchocerca volvulus 0.005 0.0113 0.0341
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0505 0.0505
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.0063
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2016 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0189 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0287 0.0437
Trypanosoma brucei lanosterol synthase 0.0034 0.0033 0.0064
Plasmodium falciparum phd finger protein, putative 0.0172 0.0727 0.9437
Echinococcus multilocularis phd:f box containing protein 0.0065 0.0189 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.3369 0.5749
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0757 0.367 0.8328
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0256 0.1148 0.1148
Loa Loa (eye worm) jmjC domain-containing protein 0.0355 0.1649 0.3483
Schistosoma mansoni hypothetical protein 0.0256 0.1148 0.1148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0346 0.1602 0.2704
Giardia lamblia Hypothetical protein 0.0128 0.0505 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.3129 0.5336
Schistosoma mansoni hypothetical protein 0.0057 0.0147 0.0147
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0283 0.1286 0.2912
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0034 0.0033 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0757 0.367 0.7765
Loa Loa (eye worm) heterochromatin protein 1 0.0213 0.0933 0.1965
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0033 0.0028
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0622 0.2992 0.2988
Toxoplasma gondii PHD-finger domain-containing protein 0.0172 0.0727 0.2081
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0462 0.0739
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0047 0.0097 0.0864
Plasmodium vivax hypothetical protein, conserved 0.0172 0.0727 0.9437
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0178 0.0756 0.0756
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.007 0.007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0757 0.367 0.8328
Trichomonas vaginalis D-aminoacylase, putative 0.0158 0.0658 0.1078
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0025 0.002
Echinococcus granulosus geminin 0.1002 0.4898 0.4898
Loa Loa (eye worm) hypothetical protein 0.0218 0.0958 0.2019
Leishmania major GTP-binding protein, putative 0.0042 0.007 0.0149
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.012 0.012
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0246 0.0511
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.0063
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0232 0.1028 0.1715
Toxoplasma gondii ABC1 family protein 0.0158 0.0658 0.1874
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.0459 0.0734
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0179 0.0763 0.2188
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.012 0.0261
Brugia malayi Pre-SET motif family protein 0.0425 0.1997 0.1997
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.018 0.0769 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.2082 0.3531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0648 0.3119 0.5318
Trichomonas vaginalis Heterochromatin protein, putative 0.0035 0.0037 0.0006
Entamoeba histolytica hypothetical protein 0.0346 0.1602 0.2745
Brugia malayi hypothetical protein 0.0134 0.0537 0.0537
Onchocerca volvulus 0.0158 0.0658 0.2757
Leishmania major cathepsin L-like protease 0.0046 0.0093 0.02
Echinococcus granulosus snurportin 1 0.0603 0.2894 0.2894
Loa Loa (eye worm) hypothetical protein 0.0256 0.1148 0.2422
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0037 0.0006
Loa Loa (eye worm) hypothetical protein 0.0062 0.0172 0.0355
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0246 0.0246
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0119 0.0462 0.1886
Echinococcus multilocularis GPCR, family 2 0.0057 0.0147 0.0147
Brugia malayi Cytochrome P450 family protein 0.006 0.0165 0.0165
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0094 0.0105
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.012 0.1186
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0586 0.1232
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0049 0.0109 0.022
Leishmania major phosphatidylinositol 3-kinase, putative 0.0602 0.2889 0.6552
Entamoeba histolytica hypothetical protein 0.0128 0.0505 0.0865
Loa Loa (eye worm) hypothetical protein 0.0128 0.0505 0.1059
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.011 0.0412 0.0925
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.0063
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0443 0.2089 0.2089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0505 0.0505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0094 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0178 0.0756 0.0756
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0158 0.0658 0.1271
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0172 0.0418
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0047 0.0097 0.0165
Brugia malayi Importin beta-1 subunit 0.0056 0.0145 0.0145
Plasmodium vivax prenyltransferase alpha subunit, putative 0.018 0.0769 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0178 0.0756 0.0756
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0181 0.0772 0.0772
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0246 0.0246
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.0158 0.0658 0.1384
Echinococcus multilocularis microtubule associated protein 2 0.069 0.333 0.333
Loa Loa (eye worm) hypothetical protein 0.0034 0.0033 0.006
Loa Loa (eye worm) hypothetical protein 0.0065 0.0189 0.039
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.012 0.0261
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0763 0.0758
Plasmodium vivax heterochromatin protein 1, putative 0.0035 0.0037 0.005
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0126 0.0494 0.1036
Plasmodium vivax hypothetical protein, conserved 0.0128 0.0505 0.6418
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0035 0.0037 0.0037
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.007 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Plasmodium vivax SET domain protein, putative 0.0062 0.0172 0.1895
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0231 0.1025 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0772 0.1274
Loa Loa (eye worm) hypothetical protein 0.0172 0.0727 0.153
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0757 0.367 0.8328
Brugia malayi Protein cec-1. 0.0035 0.0037 0.0037
Echinococcus multilocularis geminin 0.1002 0.4898 0.4898
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0283 0.1286 0.216
Schistosoma mansoni aldehyde dehydrogenase 0.0101 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.0203
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0505 0.1059
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0246 0.0511
Schistosoma mansoni fkbp-rapamycin associated protein 0.0346 0.1602 0.1602
Trypanosoma cruzi PAB1-binding protein , putative 0.0067 0.0199 0.0194
Echinococcus multilocularis dnaJ subfamily B 0.0287 0.1304 0.1304
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.0459 0.0734
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.018 0.0769 0.0769
Giardia lamblia GTOR 0.0757 0.367 0.6268
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0757 0.367 0.6289
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0772 0.1274
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.3128 0.5334
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0223 0.0985 0.2227
Onchocerca volvulus 0.0483 0.2291 1
Plasmodium vivax JmjC domain containing protein 0.0065 0.0189 0.2121
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0037 0.0006
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0602 0.2889 0.6552
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0065 0.0189 0.0418
Loa Loa (eye worm) hypothetical protein 0.0059 0.0159 0.0326
Trypanosoma cruzi lanosterol synthase, putative 0.0034 0.0033 0.0028
Mycobacterium leprae Probable lipase LipE 0.0158 0.0658 0.0674
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0158 0.0658 0.1271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.319 0.5441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0037 0.0006
Entamoeba histolytica hypothetical protein 0.0046 0.0092 0.0157
Brugia malayi Trypsin family protein 0.0103 0.0377 0.0377
Brugia malayi AF-10 protein 0.0056 0.0144 0.0144
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0179 0.0763 0.9925
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0443 0.2089 0.2089
Leishmania major phosphatidylinositol 3-kinase, putative 0.0179 0.0763 0.1722
Brugia malayi jmjC domain containing protein 0.0247 0.1105 0.1105
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0757 0.367 0.367
Brugia malayi PHD-finger family protein 0.0059 0.0159 0.0159
Loa Loa (eye worm) latrophilin receptor protein 2 0.0057 0.0147 0.0302
Echinococcus granulosus JmjC domain containing protein 4 0.0065 0.0189 0.0189
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0346 0.1602 0.3628
Echinococcus multilocularis Chromo domain 0.0035 0.0037 0.0037
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0128 0.0505 0.0505
Leishmania major phosphatidylinositol 4-kinase, putative 0.0128 0.0505 0.1136
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.06 0.2878 0.2878
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0505 0.1059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0757 0.367 0.367
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0033 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0178 0.0756 0.0756
Echinococcus multilocularis Chromobox protein 3 0.0035 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0123 0.0479 0.0479
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0101 0.0367 0.0367
Leishmania major mitochondrial DNA polymerase beta 0.0231 0.1025 0.2318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.018 0.0765 0.1611
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0179 0.0763 0.1606
Loa Loa (eye worm) hypothetical protein 0.0158 0.0658 0.1384
Toxoplasma gondii hypothetical protein 0.0134 0.0533 0.15
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0494 0.2348 0.4023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0622 0.2992 0.5126
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0038 0.0051 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0622 0.2992 0.5099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.3429 0.5854
Schistosoma mansoni hypothetical protein 0.0056 0.0144 0.0144
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0648 0.3119 0.5345
Leishmania major hypothetical protein, conserved 0.0128 0.0505 0.1136
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2016 1 1
Echinococcus granulosus cpg binding protein 0.0053 0.0128 0.0128
Brugia malayi beta-lactamase family protein 0.0158 0.0658 0.0658
Schistosoma mansoni hypothetical protein 0.003 0.0013 0.0013
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0128 0.0505 0.6418
Echinococcus multilocularis jumonji domain containing protein 0.024 0.1066 0.1066
Brugia malayi beta-lactamase 0.0158 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0067 0.0199 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.319 0.5441
Mycobacterium tuberculosis Probable hydrolase 0.0158 0.0658 0.1271
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0128 0.0505 0.1415
Brugia malayi jmjC domain containing protein 0.0065 0.0189 0.0189
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0283 0.1286 0.2204
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0038 0.0051 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.1997 0.422
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.018 0.0769 0.1268
Toxoplasma gondii PHD-finger domain-containing protein 0.0172 0.0727 0.2081
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0246 0.0246
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0179 0.0763 0.1307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.0756 0.0756
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0063 0.0052
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0034 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.3369 0.5749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0172 0.0172
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0763 0.1722
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0126 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0158 0.0658 0.1384
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0035 0.0037 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.3128 0.5334
Loa Loa (eye worm) hypothetical protein 0.0158 0.0658 0.1384
Plasmodium vivax hypothetical protein 0.0128 0.0505 0.6418
Trichomonas vaginalis D-aminoacylase, putative 0.0158 0.0658 0.1078
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.007 0.0139
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0158 0.0658 0.0658
Leishmania major phosphatidylinositol kinase related protein, putative 0.0128 0.0505 0.1136
Onchocerca volvulus 0.0094 0.0332 0.131
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0158 0.0658 0.2355
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.018 0.0769 0.1268
Loa Loa (eye worm) hypothetical protein 0.0443 0.2089 0.4415
Schistosoma mansoni gabp alpha 0.0049 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.3128 0.5334
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0518 0.2468 0.423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.0756 0.0756
Echinococcus multilocularis lysine specific demethylase 6a 0.0065 0.0189 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0757 0.367 0.6268
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.058 0.278 0.5583
Loa Loa (eye worm) phosphatidylinositol 3 0.0967 0.4725 1
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0037
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.3129 0.5336
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0772 0.1274
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1071 0.5248 0.5248
Brugia malayi follicle stimulating hormone receptor 0.0294 0.1338 0.1338
Trichomonas vaginalis chromobox protein, putative 0.0128 0.0507 0.0818
Brugia malayi Cytochrome P450 family protein 0.0029 0.0005 0.0005
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0047 0.0097 0.0097
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0339 0.1565 0.2683
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0179 0.0763 0.0763
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0128 0.0505 0.6418
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0067
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1188 0.5835 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0189 0.039
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0065 0.0189 0.0184
Leishmania major farnesyltransferase beta subunit 0.0126 0.0494 0.1112
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0346 0.1602 0.1598
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0246 0.0246
Mycobacterium tuberculosis Conserved protein 0.0158 0.0658 0.1271
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0256 0.1148 0.1148
Brugia malayi hypothetical protein 0.0043 0.0079 0.0079
Plasmodium falciparum heterochromatin protein 1 0.0035 0.0037 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.2143 0.3636
Brugia malayi Valyl-tRNA synthetase 0.0035 0.0037 0.0037
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0283 0.1286 0.2204
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0065 0.0189 0.0468
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0505 0.1059
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0189 0.039
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0037 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0094 0.0105
Echinococcus granulosus Chromo domain 0.0035 0.0037 0.0037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0158 0.0658 0.1271
Entamoeba histolytica hypothetical protein 0.0128 0.0505 0.0865
Onchocerca volvulus 0.0134 0.0537 0.2217
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0126 0.0494 0.0847
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0156 0.0156
Brugia malayi FAT domain containing protein 0.0256 0.1148 0.1148
Mycobacterium ulcerans lipase LipD 0.0158 0.0658 0.2355
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1188 0.5835 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0101 0.0367 0.1305
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0047 0.0097 0.0097
Onchocerca volvulus 0.0128 0.0505 0.2077
Schistosoma mansoni chromobox protein 0.0213 0.0933 0.0933
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0047 0.0097 0.0109
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.018 0.0769 0.1618
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0034 0.0033 0.0028
Mycobacterium ulcerans beta-lactamase 0.0158 0.0658 0.2355
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0128 0.0505 0.0505
Brugia malayi Latrophilin receptor protein 2 0.0057 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0119 0.0462 0.0968
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0037 0.005
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0034 0.0033 0.006
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0068 0.0203 0.0203
Giardia lamblia Rab geranylgeranyltransferase 0.0047 0.0097 0.0109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.018 0.0765 0.0765
Trichomonas vaginalis D-aminoacylase, putative 0.0158 0.0658 0.1078
Echinococcus multilocularis serine protein kinase ATM 0.0346 0.1602 0.1602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0697 0.3369 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.005 0.0113 0.023
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.058 0.278 1
Toxoplasma gondii hypothetical protein 0.0037 0.0049 0.0048
Giardia lamblia Prenyltransferase 0.0126 0.0494 0.0795
Brugia malayi F/Y-rich N-terminus family protein 0.0074 0.0233 0.0233
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0099 0.0892
Schistosoma mansoni hypothetical protein 0.0128 0.0505 0.0505
Brugia malayi MH2 domain containing protein 0.0144 0.0586 0.0586
Loa Loa (eye worm) acetyltransferase 0.0175 0.0742 0.1561
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.071 0.343 0.7784
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.007 0.0509
Leishmania major geranylgeranyltransferase, putative 0.0034 0.0033 0.0064
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0092 0.0323 0.3936
Brugia malayi chromobox protein homolog 3 0.0119 0.0462 0.0462
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0037 0.0063
Echinococcus granulosus serine protein kinase ATM 0.0346 0.1602 0.1602
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0034 0.0033 0.0033
Brugia malayi Cytochrome P450 family protein 0.0029 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0287 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.3129 0.5336
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0047 0.0097 0.0097
Echinococcus granulosus lysine specific demethylase 6a 0.0065 0.0189 0.0189
Brugia malayi jmjC domain containing protein 0.06 0.2878 0.2878
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0128 0.0505 0.6418
Plasmodium vivax ataxin-2 like protein, putative 0.0067 0.0199 0.2251
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0126 0.0494 0.0494
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0763 0.1722
Onchocerca volvulus 0.0158 0.0658 0.2757
Echinococcus granulosus GPCR family 2 0.0057 0.0147 0.0147
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0643 0.0638
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0757 0.367 0.6289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0757 0.367 0.6268
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0165 0.0338
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.007 0.0149
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0346 0.1602 0.1602
Trypanosoma brucei target of rapamycin kinase 3, putative 0.071 0.343 0.7784
Brugia malayi SET domain containing protein 0.0038 0.0053 0.0053
Onchocerca volvulus 0.0096 0.0344 0.1362
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0033 0.0025 0.002
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0037 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0904 0.4406 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0126 0.0494 0.1112
Schistosoma mansoni phd/f-box containing protein 0.0065 0.0189 0.0189
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0742 0.0742
Brugia malayi PHD-finger family protein 0.0172 0.0727 0.0727
Plasmodium vivax importin-beta 2, putative 0.0056 0.0145 0.1529
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0038 0.0051 0.0051
Brugia malayi Heterochromatin protein 1 0.0213 0.0933 0.0933
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0103 0.0377 0.0789
Leishmania major hypothetical protein, conserved 0.0065 0.0189 0.0418
Mycobacterium tuberculosis Conserved protein 0.0158 0.0658 0.1271
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0034 0.0033 0.0033
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0037 0.0037
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.018 0.0769 0.1317
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0128 0.0505 0.1136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0128 0.0505 0.0959
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0065 0.0189 0.0189
Toxoplasma gondii histone lysine methyltransferase SET1 0.0101 0.0372 0.1016
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.003 0.0013 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.0101 0.0367 0.1001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0101 0.0367 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0176 0.0745 0.1226
Trypanosoma brucei hypothetical protein, conserved 0.0158 0.0658 0.1485
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.0459 0.0734
Brugia malayi jmjC domain containing protein 0.0065 0.0189 0.0189
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.018 0.0769 0.0769
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0586 0.1232
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0742 0.0742
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0231 0.1025 0.1021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1012 0.4953 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0231 0.1025 0.2318
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0057 0.0147 0.0147
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0449 0.2118 0.2118
Echinococcus multilocularis cpg binding protein 0.0053 0.0128 0.0128
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0145 0.0145
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0034 0.0033 0.0057
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0034 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0283 0.1286 0.1286
Onchocerca volvulus Alhambra homolog 0.0172 0.0727 0.3062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0172 0.0172
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0126 0.0494 0.0795
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0179 0.0763 0.0763
Brugia malayi Bromodomain containing protein 0.0176 0.0749 0.0749
Brugia malayi CXXC zinc finger family protein 0.005 0.0113 0.0113
Brugia malayi Calcitonin receptor-like protein seb-1 0.018 0.0765 0.0765
Trichomonas vaginalis penicillin-binding protein, putative 0.0158 0.0658 0.1078
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2016 1 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0065 0.0189 0.0189
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0179 0.0763 0.0763
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.007 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.0459 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Entamoeba histolytica hypothetical protein 0.0128 0.0505 0.0865
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0035 0.0037 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0158 0.0658 0.0658
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0443 0.2089 0.2089
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0093 0.0088
Treponema pallidum fructose-bisphosphate aldolase 0.1188 0.5835 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0172 0.0172
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0128 0.0505 0.05
Brugia malayi latrophilin 2 splice variant baaae 0.0123 0.0479 0.0479
Leishmania major hypothetical protein, conserved 0.0067 0.0199 0.044
Echinococcus multilocularis GA binding protein alpha chain 0.0049 0.0109 0.0109
Schistosoma mansoni ran 0.0042 0.007 0.007
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0757 0.367 0.8328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Trypanosoma cruzi major cysteine proteinase, putative 0.0036 0.0043 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1188 0.5835 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0109 0.0407 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0384 0.1792 0.3031
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0246 0.0246
Echinococcus granulosus peregrin 0.0176 0.0749 0.0749
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0126 0.0494 0.627
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0126 0.0494 0.0494
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0047 0.0097 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0772 0.1274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0094 0.0105
Loa Loa (eye worm) hypothetical protein 0.0302 0.1379 0.291
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0128 0.0505 0.6418
Brugia malayi Fli-1 protein 0.0149 0.0612 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Brugia malayi TAR-binding protein 0.0076 0.0246 0.0246
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0047 0.0097 0.0208
Loa Loa (eye worm) hypothetical protein 0.0103 0.0377 0.0789
Mycobacterium tuberculosis Probable lipase LipD 0.0158 0.0658 0.1271
Onchocerca volvulus 0.0047 0.0097 0.0266
Loa Loa (eye worm) hypothetical protein 0.018 0.0765 0.1611
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0179 0.0763 0.1258
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0059 0.016 0.1722
Schistosoma mansoni hypothetical protein 0.0287 0.1304 0.1304
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2016 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.0459 0.0734
Echinococcus granulosus lysine specific demethylase 5A 0.0247 0.1105 0.1105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0172 0.0172
Toxoplasma gondii FATC domain-containing protein 0.0346 0.1602 0.4703
Brugia malayi beta-lactamase family protein 0.0158 0.0658 0.0658
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.3369 0.5749
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0042 0.0073 0.0068
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0047 0.0097 0.0194
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0128 0.0505 0.05
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0034 0.0033 0.0033
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0101 0.0367 0.0679
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0246 0.0246
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0092 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.2082 0.3531
Echinococcus multilocularis peregrin 0.0176 0.0749 0.0749
Trypanosoma cruzi protein farnesyltransferase, putative 0.0126 0.0494 0.0489
Echinococcus granulosus jumonji domain containing 1A 0.0065 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.1002 0.4898 0.4898
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0346 0.1602 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0697 0.3369 0.5749
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0622 0.2992 0.5099
Onchocerca volvulus 0.0158 0.0658 0.2757
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0056 0.0144 0.0317
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0218 0.0958 0.0954
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0757 0.367 0.3667
Loa Loa (eye worm) beta-lactamase 0.0158 0.0658 0.1384
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0067
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.018 0.0769 0.0769
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0033 0.0025 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0757 0.367 0.6268
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0128 0.0505 0.0505
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 0.0377 0.0377
Mycobacterium tuberculosis Conserved hypothetical protein 0.0122 0.0474 0.0897
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.012 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.2383 0.405
Loa Loa (eye worm) phosphatidylinositol 3 0.0904 0.4406 0.9324
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0037 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0037 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.0756 0.0756
Echinococcus granulosus GA binding protein alpha chain 0.0049 0.0109 0.0109
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0047 0.0097 0.0092
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0101 0.0367 0.0823
Loa Loa (eye worm) hypothetical protein 0.0134 0.0537 0.1126
Mycobacterium ulcerans esterase/lipase LipP 0.0158 0.0658 0.2355
Brugia malayi Ets-domain containing protein 0.0049 0.0109 0.0109
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0179 0.0763 0.9925
Brugia malayi RNA, U transporter 1 0.0161 0.0669 0.0669
Brugia malayi RNA binding protein 0.0076 0.0246 0.0246
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.0093 0.0088
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0126 0.0494 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.3129 0.5336
Leishmania major importin beta-1 subunit, putative 0.0046 0.0092 0.0197
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0179 0.0763 0.0763
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0128 0.0505 0.05
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0056 0.0144 0.0334
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0037 0.005
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0034 0.0033 0.0057
Loa Loa (eye worm) RNA binding protein 0.0076 0.0246 0.0511
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0047 0.0097 0.0208
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0283 0.1286 0.216
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0067
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0179 0.0763 0.1307
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0463 0.2189 0.3716
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0412 0.0407
Schistosoma mansoni jumonji domain containing protein 0.0484 0.2295 0.2295
Leishmania major phosphatidylinositol kinase, putative 0.0128 0.0505 0.1136
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.007 0.0066
Giardia lamblia Fructose-bisphosphate aldolase 0.1188 0.5835 1
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0035 0.0037 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0904 0.4406 0.7536
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0034 0.0033 0.0033
Plasmodium falciparum JmjC domain-containing protein, putative 0.0065 0.0189 0.2121
Schistosoma mansoni hypothetical protein 0.0057 0.0147 0.0147
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0218 0.0218
Schistosoma mansoni chromobox protein 0.0213 0.0933 0.0933
Schistosoma mansoni protein phosphatase 2C 0.0065 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0158 0.0658 0.0654
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0128 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0065 0.0189 0.039
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0068 0.0203 0.0203
Schistosoma mansoni aldehyde dehydrogenase 0.0101 0.0367 0.0367
Echinococcus granulosus chromobox protein 1 0.0213 0.0933 0.0933
Schistosoma mansoni hypothetical protein 0.0057 0.0147 0.0147
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0128 0.0505 0.0505
Leishmania major hypothetical protein, unknown function 0.0128 0.0505 0.1136
Trichomonas vaginalis ran, putative 0.0042 0.007 0.0064
Loa Loa (eye worm) phosphatidylinositol kinase 0.0128 0.0505 0.1059
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0047 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0602 0.2889 0.4921
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0067 0.0059
Echinococcus granulosus chromobox protein 2 0.0035 0.0037 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0247 0.1105 0.1105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0101 0.0367 0.1305
Trichomonas vaginalis chromobox protein, putative 0.0213 0.0933 0.155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0093 0.02
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0128 0.0505 0.05
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0128 0.0505 0.05
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0179 0.0763 0.1258
Brugia malayi hypothetical protein 0.0035 0.0037 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0057 0.0147 0.0147
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0128 0.0505 0.1136
Echinococcus granulosus phd:f box containing protein 0.0065 0.0189 0.0189

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 39.44 um PUBCHEM_BIOASSAY: Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3). (Class of assay: confirmatory) [Related pubchem assays: 746 ] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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