TDR Targets

Basic information

Technical information

TDR Targets ID: 1438244
Name: N-(6-methoxy-1,3-benzothiazol-2-yl)-1-(4-meth ylphenyl)sulfonylpyrrolidine-2-carboxamide
MW: 431.528 | Formula: C20H21N3O4S2
H donors: 1 H acceptors: 4 LogP: 3.62 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)sc(n2)NC(=O)C1CCCN1S(=O)(=O)c1ccc(cc1)C
InChi: 1S/C20H21N3O4S2/c1-13-5-8-15(9-6-13)29(25,26)23-11-3-4-17(23)19(24)22-20-21-16-10-7-14(27-2)12-18(16)28-20/h5-10,12,17H,3-4,11H2,1-2H3,(H,21,22,24)
InChiKey: SYJRNPNZKCSVKM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(6-methoxy-1,3-benzothiazol-2-yl)-1-(4-methylphenyl)sulfonyl-pyrrolidine-2-carboxamide
N-(6-methoxy-1,3-benzothiazol-2-yl)-1-(4-methylphenyl)sulfonyl-2-pyrrolidinecarboxamide
SMR000105605
Oprea1_467898
BIM-0005779.P001
CBMicro_005859
EU-0068363
MLS000109665

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Bacillus anthracis	Anthrax lethal factor	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved hypothetical protein	0.003	0.0047	1
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1608	0.1602
Brugia malayi	intermediate filament protein	0.0033	0.006	0.006
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0047	0.0047
Schistosoma mansoni	sodium/chloride dependent transporter	0.0333	0.1608	0.1608
Echinococcus multilocularis	lamin	0.0033	0.006	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0033	0.006	0.0053
Echinococcus granulosus	cGMP dependent protein kinase 1	0.003	0.0047	0.0047
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.003	0.0047	0.0047
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0228	0.1067	0.1067
Echinococcus multilocularis	serotonin transporter	0.1962	1	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0104	0.0098
Brugia malayi	hypothetical protein	0.0333	0.1608	0.1608
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.003	0.0047	0.0047
Schistosoma mansoni	cytochrome P450	0.0022	0.0007	0.0007
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0333	0.1608	0.1602
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0007	0.0007
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0045	0.0125	0.0118
Echinococcus granulosus	voltage gated potassium channel	0.0066	0.0232	0.0232
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.003	0.0047	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0228	0.1067	0.1061
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.1175	0.1175
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0007	0.0007
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.003	0.0047	0.5
Leishmania major	hypothetical protein, conserved	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1608	0.1602
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0333	0.1608	0.1608
Mycobacterium ulcerans	hypothetical protein	0.003	0.0047	1
Onchocerca volvulus		0.0033	0.006	0.0013
Schistosoma mansoni	voltage-gated potassium channel	0.0036	0.0077	0.0077
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0045	0.0125	0.1258
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0045	0.0125	0.0125
Echinococcus multilocularis	lamin dm0	0.0033	0.006	0.0053
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.003	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1608	0.1602
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.003	0.0047	0.0047
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.003	0.0047	0.0477
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0045	0.0125	0.0125
Brugia malayi	cytochrome P450	0.0022	0.0007	0.0007
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.003	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0041	0.0104	0.0104
Schistosoma mansoni	intermediate filament proteins	0.0033	0.006	0.006
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0333	0.1608	0.1608
Brugia malayi	Egg laying defective protein 4	0.003	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0022	0.0007	0.0007
Mycobacterium leprae	putative cytochrome p450	0.0022	0.0007	0.1386
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0333	0.1608	0.1608
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.003	0.0047	0.0047
Echinococcus granulosus	cGMP dependent protein kinase 1	0.003	0.0047	0.0047
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0104	0.0104
Leishmania major	cyclic nucleotide-binding protein-like protein	0.003	0.0047	1
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.003	0.0047	0.0047
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0022	0.0007	0.1386
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0333	0.1608	0.1602
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.006	0.006
Echinococcus granulosus	patatin phospholipase domain containing protein	0.003	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0232	0.0226
Brugia malayi	N-terminal motif family protein	0.003	0.0047	0.0047
Schistosoma mansoni	voltage-gated potassium channel	0.0066	0.0232	0.0232
Mycobacterium ulcerans	hypothetical protein	0.003	0.0047	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0635	0.0629
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0045	0.0125	0.0118
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0333	0.1608	0.1608
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0228	0.1067	0.1067
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0333	0.1608	0.1608
Leishmania major	regulatory subunit of protein kinase a-like protein	0.003	0.0047	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.003	0.0047	0.0254
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.003	0.0047	0.0254
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0333	0.1608	0.1602
Leishmania major	hypothetical protein, conserved	0.003	0.0047	1
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.003	0.0047	0.0047
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0333	0.1608	0.1608
Plasmodium vivax	hypothetical protein, conserved	0.0333	0.1608	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.1962	1	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0045	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.003	0.0047	0.0041
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0066	0.0232	0.0232
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0045	0.0125	0.0125
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0045	0.0125	0.0118
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.003	0.0047	0.0047
Leishmania major	protein kinase, putative	0.003	0.0047	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.003	0.0047	0.0047
Onchocerca volvulus		0.0333	0.1608	0.1568
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0333	0.1608	0.1608
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.003	0.0047	0.0047
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0228	0.1067	0.1061
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	0.1602
Plasmodium falciparum	amino acid transporter, putative	0.0333	0.1608	1
Schistosoma mansoni	lamin	0.0033	0.006	0.006
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.003	0.0047	0.0047
Treponema pallidum	sodium- and chloride- dependent transporter	0.1962	1	1
Trypanosoma brucei	Flagellar Member 6	0.003	0.0047	1
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.1962	1	1
Onchocerca volvulus		0.0333	0.1608	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0057	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0047	0.0477
Echinococcus granulosus	sodium and chloride dependent glycine	0.0333	0.1608	0.1608
Trypanosoma brucei	cytochrome P450, putative	0.0022	0.0007	0.1386
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0045	0.0125	0.0118
Mycobacterium leprae	Conserved hypothetical protein	0.003	0.0047	1
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.003	0.0047	0.0047
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.003	0.0047	0.0041
Mycobacterium ulcerans	regulatory protein	0.003	0.0047	1
Echinococcus granulosus	cytochrome P450 2K1	0.0022	0.0007	0.0007
Plasmodium falciparum	transporter, putative	0.0333	0.1608	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0066	0.0232	0.0232
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0333	0.1608	0.1602
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0045	0.0125	0.0118
Loa Loa (eye worm)	hypothetical protein	0.003	0.0047	0.0041
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.006	0.0053
Trypanosoma cruzi	cAMP response protein 1	0.003	0.0047	1
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0007	0.0007
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0333	0.1608	0.1602
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1608	0.1602
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0202	0.0202
Onchocerca volvulus		0.0333	0.1608	0.1568
Echinococcus multilocularis	voltage gated potassium channel	0.0066	0.0232	0.0226
Mycobacterium ulcerans	hypothetical protein	0.003	0.0047	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0045	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.1962	1	1
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.003	0.0047	0.0254
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1608	0.1602
Brugia malayi	MH2 domain containing protein	0.0144	0.0635	0.0635
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0635	0.0629
Mycobacterium tuberculosis	Conserved hypothetical protein	0.003	0.0047	1
Trypanosoma cruzi	cAMP response protein 1, putative	0.003	0.0047	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0333	0.1608	0.1608
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.003	0.0047	0.0477
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0333	0.1608	0.1608
Mycobacterium ulcerans	transcriptional regulatory protein	0.003	0.0047	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0045	0.0125	0.0125
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0213	0.0989	1
Trypanosoma cruzi	protein kinase A regulatory subunit	0.003	0.0047	1
Schistosoma mansoni	60S ribosomal protein L21	0.0036	0.0077	0.0077
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.006	0.0053
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.003	0.0047	0.0254
Schistosoma mansoni	lamin	0.0033	0.006	0.006
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0202	0.0196
Echinococcus granulosus	sodium and chloride dependent glycine	0.0333	0.1608	0.1608
Echinococcus granulosus	intermediate filament protein	0.0033	0.006	0.006
Mycobacterium ulcerans	transmembrane transport protein	0.003	0.0047	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0333	0.1608	0.1608
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0333	0.1608	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0045	0.0125	0.1258
Leishmania major	protein kinase, putative	0.003	0.0047	1
Leishmania major	protein kinase A regulatory subunit, putative	0.003	0.0047	1
Mycobacterium tuberculosis	Conserved protein	0.003	0.0047	1
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.003	0.0047	0.0047
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.003	0.0047	0.0047
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0045	0.0125	0.0125
Echinococcus granulosus	serotonin transporter	0.1962	1	1
Schistosoma mansoni	hypothetical protein	0.003	0.0047	0.0047
Echinococcus granulosus	hyperpolarization activated cyclic	0.0045	0.0125	0.0125
Trypanosoma brucei	cAMP binding protein, putative	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0912	0.0906
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1962	1	1
Loa Loa (eye worm)	serotonin transporter b	0.1962	1	1
Mycobacterium ulcerans	hypothetical protein	0.003	0.0047	1
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0047	0.0047
Toxoplasma gondii	hypothetical protein	0.0333	0.1608	1
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.003	0.0047	1
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.003	0.0047	0.0041
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.003	0.0047	0.0254
Echinococcus granulosus	lamin dm0	0.0033	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1608	0.1602
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	0.1602
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0333	0.1608	0.1608
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.003	0.0047	0.0041
Onchocerca volvulus		0.0033	0.006	0.0013
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.003	0.0047	0.0041
Schistosoma mansoni	voltage-gated potassium channel	0.0066	0.0232	0.0232
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.0007	0.1386
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0007	0.0007
Loa Loa (eye worm)	norepinephrine transporter	0.1962	1	1
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.003	0.0047	0.0047
Plasmodium vivax	amine transporter, putative	0.0333	0.1608	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0333	0.1608	0.1608
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0045	0.0125	0.0125
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1962	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	0.1608
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0045	0.0125	0.0125
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0125	0.0125
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0202	0.0202
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.003	0.0047	0.0047
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.003	0.0047	1
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.003	0.0047	0.0477
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.003	0.0047	1
Leishmania major	hypothetical protein, conserved	0.003	0.0047	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0333	0.1608	0.1608
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.003	0.0047	0.0477
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0045	0.0125	0.0125
Echinococcus multilocularis	musashi	0.0033	0.006	0.0053
Trypanosoma cruzi	Flagellar Member 6	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1608	0.1602
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.003	0.0047	0.0047
Onchocerca volvulus		0.1962	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	0.1608
Trypanosoma cruzi	cAMP binding protein, putative	0.003	0.0047	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0333	0.1608	0.1608
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.003	0.0047	0.0254
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.003	0.0047	0.0041
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.003	0.0047	0.0041
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0045	0.0125	0.0118
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0213	0.0989	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0045	0.0125	0.0118
Loa Loa (eye worm)	hypothetical protein	0.1962	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0066	0.0232	0.0226
Schistosoma mansoni	sodium/chloride dependent transporter	0.0333	0.1608	0.1608
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.003	0.0047	0.0041
Schistosoma mansoni	voltage-gated potassium channel	0.0249	0.1175	0.1175
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.003	0.0047	1
Trypanosoma brucei	protein kinase A regulatory subunit	0.003	0.0047	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.003	0.0047	0.0047
Echinococcus granulosus	lamin	0.0033	0.006	0.006
Echinococcus multilocularis	expressed conserved protein	0.003	0.0047	0.0041
Echinococcus granulosus	cGMP dependent protein kinase	0.003	0.0047	0.0047
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0333	0.1608	0.1608
Toxoplasma gondii	hypothetical protein	0.0333	0.1608	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0045	0.0125	0.0125
Leishmania major	hypothetical protein, unknown function	0.003	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0196
Loa Loa (eye worm)	AGC/PKG protein kinase	0.003	0.0047	0.0041
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0047	0.0047
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.003	0.0047	1
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.003	0.0047	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0125	0.0118
Trypanosoma brucei	cAMP response protein 1, putative	0.003	0.0047	1
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.003	0.0047	0.0041

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	57.5 uM	PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628]	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	100 uM	PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1602963

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1438244