Detailed information for compound 1445768

Basic information

Technical information
  • TDR Targets ID: 1445768
  • Name: 1-(3,4-dimethyl-2-phenylpyrazolo[3,4-d]pyrida zin-7-yl)-N-[3-(trifluoromethyl)phenyl]piperi dine-3-carboxamide
  • MW: 494.512 | Formula: C26H25F3N6O
  • H donors: 1 H acceptors: 4 LogP: 4.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN(C1)c1nnc(c2c1nn(c2C)c1ccccc1)C)Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C26H25F3N6O/c1-16-22-17(2)35(21-11-4-3-5-12-21)33-23(22)24(32-31-16)34-13-7-8-18(15-34)25(36)30-20-10-6-9-19(14-20)26(27,28)29/h3-6,9-12,14,18H,7-8,13,15H2,1-2H3,(H,30,36)
  • InChiKey: WRRYGYCSFSGLFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(3,4-dimethyl-2-phenyl-pyrazolo[3,4-d]pyridazin-7-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-3-carboxamide
  • 1-(3,4-dimethyl-2-phenyl-7-pyrazolo[3,4-d]pyridazinyl)-N-[3-(trifluoromethyl)phenyl]-3-piperidinecarboxamide
  • 1-(3,4-dimethyl-2-phenyl-pyrazolo[3,4-d]pyridazin-7-yl)-N-[3-(trifluoromethyl)phenyl]nipecotamide
  • E859-1731
  • NCGC00141394-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0304 0.0394
Loa Loa (eye worm) hypothetical protein 0.018 0.3131 0.3131
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Echinococcus granulosus tumor protein p63 0.0408 0.831 0.831
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0068 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0128 0.1962 0.1962
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Echinococcus multilocularis C type lectin domian containing protein 0.0095 0.1226 0.1226
Brugia malayi Myb-like DNA-binding domain containing protein 0.0077 0.0804 0.1517
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Echinococcus multilocularis anosmin 1 0.0103 0.1388 0.1388
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.5
Brugia malayi GCC2 and GCC3 family protein 0.0095 0.1226 0.2359
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0068 0.061 0.061
Echinococcus granulosus cell adhesion molecule 0.0103 0.1388 0.1388
Echinococcus granulosus anosmin 1 0.0103 0.1388 0.1388
Schistosoma mansoni titin 0.0077 0.0804 0.083
Schistosoma mansoni nephrin 0.0221 0.407 0.4202
Echinococcus granulosus tyrosine protein kinase Fyn 0.0068 0.061 0.061
Brugia malayi SH2 domain containing protein 0.0055 0.0303 0.0515
Schistosoma mansoni protein kinase 0.0042 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Brugia malayi Tyrosine-protein kinase abl-1 0.0264 0.505 1
Onchocerca volvulus 0.0095 0.1226 0.1942
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0068 0.061 0.061
Onchocerca volvulus 0.0103 0.1388 0.2283
Schistosoma mansoni tyrosine kinase 0.0184 0.324 0.3345
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2974 0.4045
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0068 0.061 0.061
Echinococcus granulosus roundabout 2 0.0189 0.335 0.335
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0807 0.1522
Onchocerca volvulus 0.0077 0.0804 0.1055
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Brugia malayi Leucine Rich Repeat family protein 0.0077 0.0807 0.1522
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0077 0.0804 0.1517
Brugia malayi Protein kinase domain containing protein 0.0055 0.0303 0.0515
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0103 0.1388 0.1388
Schistosoma mansoni hypothetical protein 0.0077 0.0804 0.083
Echinococcus granulosus insulin receptor 0.0222 0.4096 0.4096
Schistosoma mansoni tyrosine kinase 0.0068 0.061 0.0629
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0103 0.1388 0.1388
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1023 0.1954
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0304 0.0394
Loa Loa (eye worm) lethal protein 805 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0118 0.1732 0.1732
Echinococcus granulosus c src tyrosine kinase 0.0068 0.061 0.061
Onchocerca volvulus 0.0077 0.0804 0.1055
Echinococcus granulosus anosmin 1 0.0103 0.1388 0.1388
Loa Loa (eye worm) SRC-1 0.0068 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.3131 0.6165
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0103 0.1388 0.1876
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.019 0.3377 0.3377
Schistosoma mansoni cell adhesion molecule 0.0154 0.2546 0.2628
Loa Loa (eye worm) CAMK protein kinase 0.0181 0.3158 0.3158
Echinococcus multilocularis twitchin 0.0078 0.0831 0.0831
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0141 0.225 0.225
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0103 0.1388 0.1433
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.3131 0.6165
Echinococcus multilocularis roundabout 2 0.0231 0.4289 0.4289
Brugia malayi Protein kinase domain containing protein 0.0113 0.1626 0.3159
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0055 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0087 0.1023 0.1023
Onchocerca volvulus Tyrosine kinase homolog 0.0264 0.5054 1
Brugia malayi Prion-like- 0.0077 0.0804 0.1517
Mycobacterium ulcerans hypothetical protein 0.0192 0.3416 0.5
Echinococcus granulosus roundabout 2 0.0189 0.335 0.335
Echinococcus granulosus neuroglian 0.0118 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0072 0.0699 0.0699
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1023 0.1954
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0077 0.0807 0.0807
Onchocerca volvulus 0.018 0.3131 0.5952
Schistosoma mansoni cell adhesion molecule 0.018 0.3131 0.3233
Loa Loa (eye worm) hypothetical protein 0.0128 0.1962 0.1962
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0055 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Brugia malayi Peroxidasin 0.0087 0.1026 0.196
Schistosoma mansoni nephrin 0.0189 0.335 0.3459
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Schistosoma mansoni hypothetical protein 0.018 0.3131 0.3233
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0103 0.1388 0.1388
Echinococcus granulosus fibronectin type III domain-containing protein 0.0103 0.1388 0.1388
Brugia malayi SH2 domain containing protein 0.0055 0.0303 0.0515
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.018 0.3131 0.3131
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0087 0.1023 0.1057
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0304 0.0304
Schistosoma mansoni titin 0.018 0.3131 0.3233
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0189 0.335 0.335
Echinococcus multilocularis peroxidasin 0.0087 0.1026 0.1026
Echinococcus granulosus peroxidasin 0.0087 0.1026 0.1026
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Schistosoma mansoni tyrosine kinase 0.0127 0.1951 0.2014
Schistosoma mansoni hypothetical protein 0.0077 0.0804 0.083
Onchocerca volvulus 0.0103 0.1388 0.2283
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0068 0.061 0.0629
Onchocerca volvulus 0.0077 0.0804 0.1055
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1023 0.1954
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Onchocerca volvulus 0.0095 0.1226 0.1942
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0042 0.0016 0.0016
Brugia malayi Fibronectin type III domain containing protein 0.0103 0.1388 0.2683
Echinococcus granulosus Fibronectin type III domain containing protein 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0087 0.1026 0.1026
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0103 0.1388 0.2683
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Echinococcus multilocularis tyrosine protein kinase shark 0.0055 0.0303 0.0303
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0095 0.1226 0.1226
Onchocerca volvulus 0.006 0.0415 0.0235
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.018 0.3131 0.3131
Echinococcus granulosus tyrosine protein kinase shark 0.0055 0.0303 0.0303
Brugia malayi SRC-1 0.0068 0.061 0.1128
Loa Loa (eye worm) hypothetical protein 0.0144 0.2327 0.2327
Onchocerca volvulus 0.0095 0.1226 0.1942
Loa Loa (eye worm) hypothetical protein 0.006 0.0415 0.0415
Onchocerca volvulus Netrin receptor homolog 0.0077 0.0804 0.1055
Onchocerca volvulus 0.0095 0.1226 0.1942
Echinococcus granulosus anosmin 1 0.0103 0.1388 0.1388
Onchocerca volvulus 0.0103 0.1388 0.2283
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0103 0.1388 0.2683
Echinococcus granulosus tyrosine kinase 0.0055 0.0303 0.0303
Schistosoma mansoni tyrosine kinase 0.0141 0.225 0.2323
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0077 0.0807 0.0807
Toxoplasma gondii rhoptry neck protein RON1 0.0095 0.1226 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0112 0.1607 0.1607
Echinococcus granulosus tyrosine protein kinase Src64B 0.0068 0.061 0.061
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0807 0.1061
Echinococcus multilocularis anosmin 1 0.0103 0.1388 0.1388
Schistosoma mansoni tyrosine kinase 0.0258 0.4901 0.506
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0051 0.0219 0.0219
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0141 0.4361
Schistosoma mansoni factor for adipocyte differentiation 0.0103 0.1388 0.1433
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.3131 0.6165
Echinococcus granulosus Netrin receptor DCC 0.0103 0.1388 0.1388
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0103 0.1388 0.1388
Brugia malayi Protein kinase domain containing protein 0.0055 0.0303 0.0515
Schistosoma mansoni protein kinase 0.0042 0.0016 0.0016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.061 0.061
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0303 0.0303
Schistosoma mansoni titin 0.0181 0.3158 0.326
Echinococcus granulosus hemicentin 1 0.0087 0.1023 0.1023
Brugia malayi Protein kinase domain containing protein 0.0222 0.4096 0.8092
Loa Loa (eye worm) hypothetical protein 0.0087 0.1023 0.1023
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.3158 0.326
Toxoplasma gondii rhoptry neck protein RON9 0.0095 0.1226 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1023 0.1023
Loa Loa (eye worm) TK/INSR protein kinase 0.0222 0.4096 0.4096
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0304 0.2379
Loa Loa (eye worm) TK protein kinase 0.0055 0.0303 0.0303
Echinococcus granulosus tyrosine protein kinase Lyn 0.0069 0.0637 0.0637
Schistosoma mansoni c4b-binding protein beta chain 0.0095 0.1226 0.1266
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Schistosoma mansoni neuroglian 0.0189 0.335 0.3459
Schistosoma mansoni hypothetical protein 0.0077 0.0804 0.083
Schistosoma mansoni cell adhesion molecule 0.0189 0.335 0.3459
Onchocerca volvulus 0.0077 0.0804 0.1055
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0189 0.335 0.335
Brugia malayi Sushi domain 0.0095 0.1226 0.2359
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Echinococcus multilocularis insulin receptor 0.0222 0.4096 0.4096
Schistosoma mansoni tripartite motif protein trim9 0.0103 0.1388 0.1433
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0077 0.0804 0.083
Echinococcus multilocularis Netrin receptor DCC 0.0103 0.1388 0.1388
Brugia malayi MAP kinase sur-1 0.0055 0.0304 0.0517
Schistosoma mansoni titin 0.0103 0.1388 0.1433
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.061 0.061
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Loa Loa (eye worm) projectin 0.018 0.3131 0.3131
Loa Loa (eye worm) UNCoordinated family member 0.0103 0.1388 0.1388
Onchocerca volvulus 0.0103 0.1388 0.2283
Onchocerca volvulus 0.0095 0.1226 0.1942
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Brugia malayi Lethal protein 805 0.0103 0.1388 0.2683
Brugia malayi myotactin form B 0.0103 0.1388 0.2683
Echinococcus granulosus titin 0.0181 0.3158 0.3158
Onchocerca volvulus 0.0077 0.0807 0.1061
Schistosoma mansoni hypothetical protein 0.0077 0.0804 0.083
Echinococcus granulosus tyrosine protein kinase otk 0.0087 0.1023 0.1023
Echinococcus multilocularis tumor protein p63 0.0408 0.831 0.831
Leishmania major hypothetical protein, conserved 0.0103 0.1388 0.1876
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0415 0.0429
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0304 0.0394
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0055 0.0303 1
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Echinococcus granulosus lachesin 0.0087 0.1023 0.1023
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7328 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0055 0.0303 0.0303
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0112 0.1607 0.1607
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0325 0.6422 0.6422
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0103 0.1388 0.1388
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Schistosoma mansoni tyrosine kinase 0.0068 0.061 0.0629
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0087 0.1023 0.1023
Echinococcus granulosus EG95 0.0103 0.1388 0.1388
Echinococcus multilocularis 0.0066 0.0565 0.0565
Brugia malayi Protein kinase domain containing protein 0.0055 0.0303 0.0515
Echinococcus multilocularis roundabout 2 0.0189 0.335 0.335
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0141 0.225 0.225
Loa Loa (eye worm) one IG domain family member 0.0077 0.0804 0.0804
Echinococcus granulosus titin 0.0077 0.0804 0.0804
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0068 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0204 0.3697 0.3697
Brugia malayi hypothetical protein 0.0055 0.0303 0.0515
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0224 0.0284
Echinococcus granulosus tyrosine kinase 0.0055 0.0303 0.0303
Onchocerca volvulus 0.0103 0.1388 0.2283
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0103 0.1388 0.1388
Schistosoma mansoni hypothetical protein 0.0103 0.1388 0.1433
Schistosoma mansoni tyrosine kinase 0.0222 0.4096 0.4228
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0304 0.0394
Echinococcus multilocularis titin 0.0181 0.3158 0.3158
Brugia malayi Tyrosine-protein kinase abl-1 0.0232 0.4317 0.8535
Echinococcus multilocularis tyrosine protein kinase otk 0.0087 0.1023 0.1023
Schistosoma mansoni tyrosine kinase 0.0143 0.2312 0.2387
Loa Loa (eye worm) hypothetical protein 0.0144 0.2327 0.2327
Onchocerca volvulus 0.0103 0.1388 0.2283
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.2974 0.4045
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0239 0.4469 0.4469
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0087 0.1023 0.1023
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0804 0.0804
Brugia malayi hypothetical protein 0.0095 0.1226 0.2359
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0189 0.335 0.335
Brugia malayi Disorganized muscle protein 1 0.0077 0.0804 0.1517
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0224 0.0284
Echinococcus multilocularis down syndrome cell adhesion 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Echinococcus granulosus neuroglian 0.0189 0.335 0.335
Trypanosoma brucei protein kinase, putative 0.0055 0.0304 0.0394
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0077 0.0804 0.0804
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0077 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Echinococcus granulosus Netrin receptor DCC 0.0103 0.1388 0.1388
Brugia malayi Lethal protein 805 0.0103 0.1388 0.2683
Echinococcus granulosus leucine rich repeat containing protein 4 0.0077 0.0804 0.0804
Echinococcus multilocularis c4b binding protein beta chain 0.0095 0.1226 0.1226
Echinococcus granulosus insulin growth factor binding 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0103 0.1388 0.1876
Onchocerca volvulus 0.0103 0.1388 0.2283
Echinococcus multilocularis insulin growth factor binding 0.0077 0.0804 0.0804
Schistosoma mansoni tyrosine kinase 0.0068 0.061 0.0629
Echinococcus multilocularis anosmin 1 0.0103 0.1388 0.1388
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.018 0.3131 0.3131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1023 0.1954
Echinococcus granulosus nephrin 0.018 0.3131 0.3131
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0478 0.0632
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0304 0.5
Echinococcus granulosus plexin a4 0.0043 0.0045 0.0045
Echinococcus multilocularis tyrosine protein kinase Srms 0.0055 0.0303 0.0303
Echinococcus granulosus titin 0.0077 0.0804 0.0804
Schistosoma mansoni roundabout 0.0087 0.1023 0.1057
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0218 0.3993 0.7888
Schistosoma mansoni tyrosine kinase 0.0469 0.9686 1
Brugia malayi Fibronectin type III domain containing protein 0.0103 0.1388 0.2683
Echinococcus multilocularis lachesin 0.0087 0.1023 0.1023
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1023 0.1954
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.324 0.324
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Schistosoma mansoni titin 0.0087 0.1023 0.1057
Schistosoma mansoni cell adhesion molecule 0.0189 0.335 0.3459
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Schistosoma mansoni septate junction protein 0.0087 0.1023 0.1057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.3416 0.5
Onchocerca volvulus 0.0103 0.1388 0.2283
Brugia malayi Prion-like- 0.0077 0.0804 0.1517
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0831 0.0858
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0103 0.1388 0.2683
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Brugia malayi protein unc-22 0.0181 0.3158 0.6219
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Loa Loa (eye worm) TK protein kinase 0.0218 0.3993 0.3993
Echinococcus granulosus tyrosine protein kinase Src42A 0.0068 0.061 0.061
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0325 0.6422 0.6422
Echinococcus multilocularis titin 0.0077 0.0804 0.0804
Echinococcus granulosus tyrosine protein kinase Fyn 0.0068 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0189 0.335 0.335
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Echinococcus multilocularis transfer RNA-Phe 0.018 0.3131 0.3131
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0224 0.0284
Schistosoma mansoni tyrosine kinase 0.0143 0.2312 0.2387
Onchocerca volvulus 0.018 0.3131 0.5952
Loa Loa (eye worm) hypothetical protein 0.0042 0.0003 0.0003
Echinococcus multilocularis neuroglian 0.0118 0.1743 0.1743
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.324 0.324
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Onchocerca volvulus 0.0077 0.0804 0.1055
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0304 0.0304
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0068 0.061 0.061
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.1388 0.1876
Schistosoma mansoni nephrin related 0.0077 0.0804 0.083
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.3131 0.6165
Echinococcus granulosus titin 0.0181 0.3158 0.3158
Schistosoma mansoni tyrosine kinase 0.0055 0.0303 0.0313
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0068 0.061 0.061
Brugia malayi SPRY domain containing protein 0.0103 0.1388 0.2683
Onchocerca volvulus 0.0103 0.1388 0.2283
Schistosoma mansoni titin 0.0077 0.0804 0.083
Echinococcus multilocularis roundabout 2 0.0189 0.335 0.335
Loa Loa (eye worm) TK/ABL protein kinase 0.0483 1 1
Loa Loa (eye worm) plexin A 0.0043 0.0045 0.0045
Plasmodium vivax apical sushi protein, putative 0.0095 0.1226 0.5
Echinococcus multilocularis hemicentin 1 0.0087 0.1023 0.1023
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0181 0.3158 0.3158
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0087 0.1023 0.1023
Echinococcus granulosus tyrosine protein kinase Fyn 0.0068 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0087 0.1023 0.1023
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Brugia malayi Prion-like- 0.0087 0.1023 0.1954
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0103 0.1388 0.1433
Echinococcus granulosus Fibronectin type III 0.0103 0.1388 0.1388
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0804 0.1517
Echinococcus granulosus epidermal growth factor receptor 0.0258 0.4901 0.4901
Brugia malayi hypothetical protein 0.0095 0.1226 0.2359
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.7328 1
Onchocerca volvulus 0.0077 0.0804 0.1055
Echinococcus multilocularis c src tyrosine kinase 0.0068 0.061 0.061
Schistosoma mansoni factor for adipocyte differentiation 0.0103 0.1388 0.1433
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.018 0.3131 0.3131
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0068 0.061 0.061
Echinococcus granulosus tyrosine protein kinase Blk 0.0055 0.0303 0.0303
Brugia malayi protein-tyrosine kinase 0.0055 0.0303 0.0515
Loa Loa (eye worm) TK/EGFR protein kinase 0.0258 0.4901 0.4901
Onchocerca volvulus Putative titin 0.0077 0.0804 0.1055
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0103 0.1388 0.1388
Onchocerca volvulus 0.0147 0.2384 0.4379
Echinococcus granulosus c4b binding protein beta chain 0.0095 0.1226 0.1226
Echinococcus granulosus contactin 0.0189 0.335 0.335
Echinococcus granulosus fibroblast growth factor receptor 4 0.0141 0.225 0.225
Loa Loa (eye worm) hypothetical protein 0.0144 0.2327 0.2327
Echinococcus multilocularis epidermal growth factor receptor 0.0258 0.4901 0.4901
Brugia malayi hypothetical protein 0.0095 0.1226 0.2359
Schistosoma mansoni hypothetical protein 0.0077 0.0804 0.083
Onchocerca volvulus 0.0103 0.1388 0.2283
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.335 0.6603
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.335 0.6603
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0055 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1023 0.1954
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0184 0.324 0.324
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0295 0.0305
Schistosoma mansoni titin 0.0077 0.0804 0.083
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Echinococcus granulosus twitchin 0.0119 0.177 0.177
Toxoplasma gondii hypothetical protein 0.0059 0.0395 0.313
Brugia malayi Fibronectin type III domain containing protein 0.0144 0.2327 0.4558
Schistosoma mansoni tyrosine kinase 0.0068 0.061 0.0629
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0304 0.0304
Onchocerca volvulus 0.0095 0.1226 0.1942
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.5
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0141 0.225 0.225
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Schistosoma mansoni cell adhesion molecule 0.0077 0.0804 0.083
Echinococcus multilocularis Fibronectin, type III 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0055 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Onchocerca volvulus 0.0095 0.1226 0.1942
Schistosoma mansoni tyrosine kinase 0.0184 0.324 0.3345
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0103 0.1388 0.1388
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0303 0.0303
Echinococcus multilocularis tyrosine protein kinase Abl 0.0232 0.4317 0.4317
Schistosoma mansoni hypothetical protein 0.0077 0.0804 0.083
Onchocerca volvulus 0.0095 0.1226 0.1942
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0103 0.1388 0.1433
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0304 0.0394
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0103 0.1388 0.1388
Plasmodium falciparum apical sushi protein 0.0095 0.1226 1
Onchocerca volvulus 0.0077 0.0804 0.1055
Echinococcus multilocularis titin 0.0077 0.0804 0.0804
Schistosoma mansoni cell adhesion molecule 0.018 0.3131 0.3233
Echinococcus granulosus G1Y162 protein 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0095 0.1226 0.1226
Brugia malayi Immunoglobulin I-set domain containing protein 0.0181 0.3158 0.6219
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0189 0.335 0.335
Onchocerca volvulus 0.0181 0.3158 0.6009
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0304 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0103 0.1388 0.1388
Brugia malayi Prion-like- 0.0077 0.0804 0.1517
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.3131 0.6165
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.3131 0.6165
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.7328 1
Brugia malayi Furin-like cysteine rich region family protein 0.0258 0.4901 0.9701
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.018 0.3131 0.3131
Brugia malayi Protein-tyrosine phosphatase 0.0103 0.1388 0.2683
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.0141 0.4361
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0304 0.0394
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2974 0.4045
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0304 0.0394
Echinococcus granulosus usherin 0.0103 0.1388 0.1388
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0068 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0077 0.0804 0.0804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0144 0.2327 0.4558
Brugia malayi Immunoglobulin I-set domain containing protein 0.0239 0.4469 0.8838
Schistosoma mansoni protein kinase 0.0042 0.0016 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0189 0.335 0.6603
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0304 0.0304
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0103 0.1388 0.1388
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0804 0.1517
Schistosoma mansoni titin 0.0077 0.0804 0.083
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0077 0.0804 0.0804
Brugia malayi hypothetical protein 0.0095 0.1226 0.2359
Echinococcus multilocularis neuroglian 0.0189 0.335 0.335
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0103 0.1388 0.1388
Echinococcus multilocularis hemicentin 1 0.0087 0.1023 0.1023
Brugia malayi Fibronectin type III domain containing protein 0.0103 0.1388 0.2683
Loa Loa (eye worm) hypothetical protein 0.0051 0.0219 0.0219
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0087 0.1023 0.1516
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0804 0.1055
Onchocerca volvulus 0.0103 0.1388 0.2283
Loa Loa (eye worm) TK/ROR protein kinase 0.0118 0.1732 0.1732
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0103 0.1388 0.1876
Schistosoma mansoni factor for adipocyte differentiation 0.0103 0.1388 0.1433
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0189 0.335 0.335
Schistosoma mansoni titin 0.0077 0.0804 0.083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.061 0.061
Schistosoma mansoni hemicentin 0.018 0.3131 0.3233
Schistosoma mansoni tyrosine kinase 0.0055 0.0303 0.0313
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0118 0.1732 0.1732
Echinococcus granulosus titin 0.0077 0.0804 0.0804
Schistosoma mansoni protein tyrosine phosphatase 0.0103 0.1388 0.1433
Brugia malayi Fibronectin type III domain containing protein 0.0103 0.1388 0.2683
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0112 0.1607 0.1607
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0068 0.061 0.061
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0077 0.0807 0.0807
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0189 0.335 0.335
Echinococcus multilocularis titin 0.0103 0.1388 0.1388
Echinococcus multilocularis usherin 0.0103 0.1388 0.1388
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0483 1 1
Brugia malayi Fibronectin type III domain containing protein 0.0103 0.1388 0.2683
Echinococcus multilocularis 0.0077 0.0804 0.0804
Brugia malayi hypothetical protein 0.0095 0.1226 0.2359
Loa Loa (eye worm) disorganized muscle protein 1 0.0077 0.0804 0.0804
Loa Loa (eye worm) myotactin form A 0.0103 0.1388 0.1388
Echinococcus multilocularis cell adhesion molecule 0.0103 0.1388 0.1388
Brugia malayi kettin 0.0077 0.0804 0.1517
Echinococcus granulosus tyrosine protein kinase Srms 0.0055 0.0303 0.0303
Onchocerca volvulus 0.0095 0.1226 0.1942
Echinococcus multilocularis Netrin receptor DCC 0.0103 0.1388 0.1388
Schistosoma mansoni ephrin receptor 0.0144 0.2316 0.2391
Echinococcus granulosus activin receptor type 0.0042 0.0016 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0304 0.0314
Loa Loa (eye worm) hypothetical protein 0.0106 0.1469 0.1469
Echinococcus granulosus roundabout 2 0.0231 0.4289 0.4289
Brugia malayi hypothetical protein 0.0095 0.1226 0.2359
Schistosoma mansoni septate junction protein 0.0087 0.1023 0.1057
Schistosoma mansoni tyrosine kinase 0.0143 0.2312 0.2387
Brugia malayi pregnancy-associated plasma protein-A 0.0095 0.1226 0.2359
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0224 0.0284
Brugia malayi hypothetical protein 0.0103 0.1388 0.2683
Loa Loa (eye worm) hypothetical protein 0.0087 0.1023 0.1023
Brugia malayi hypothetical protein 0.0144 0.2327 0.4558
Loa Loa (eye worm) hypothetical protein 0.0087 0.1023 0.1023
Brugia malayi hypothetical protein 0.0095 0.1226 0.2359
Brugia malayi myotactin form A 0.0103 0.1388 0.2683
Echinococcus multilocularis titin 0.0077 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0103 0.1388 0.1388
Echinococcus multilocularis tyrosine kinase 0.0055 0.0303 0.0303
Echinococcus granulosus down syndrome cell adhesion 0.0077 0.0804 0.0804
Brugia malayi Protein kinase domain containing protein 0.0055 0.0303 0.0515
Brugia malayi Immunoglobulin I-set domain containing protein 0.0112 0.1607 0.312
Echinococcus multilocularis activin receptor type 0.0042 0.0016 0.0016
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0042 0.0016 0.0016
Echinococcus multilocularis plexin a4 0.0043 0.0045 0.0045
Schistosoma mansoni tyrosine kinase 0.0222 0.4096 0.4228
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0103 0.1388 0.1433
Schistosoma mansoni cell adhesion molecule 0.0087 0.1023 0.1057
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0077 0.0804 0.0804
Brugia malayi Protein kinase domain containing protein 0.0055 0.0303 0.0515
Echinococcus granulosus C type lectin domian containing protein 0.0095 0.1226 0.1226
Onchocerca volvulus 0.0095 0.1226 0.1942
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7328 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0189 0.335 0.3459
Schistosoma mansoni hypothetical protein 0.0103 0.1388 0.1433
Schistosoma mansoni slit 0.0077 0.0807 0.0833
Schistosoma mansoni myosin-binding protein-related 0.018 0.3131 0.3233

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1259 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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