Detailed information for compound 1446688

Basic information

Technical information
  • TDR Targets ID: 1446688
  • Name: (2-cyclopropyl-5-oxo-[1,3,4]thiadiazolo[3,2-a ]pyrimidin-7-yl)methyl 2-(2-methylphenoxy)ace tate
  • MW: 371.41 | Formula: C18H17N3O4S
  • H donors: 0 H acceptors: 2 LogP: 2.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccccc1C)OCc1cc(=O)n2c(n1)sc(n2)C1CC1
  • InChi: 1S/C18H17N3O4S/c1-11-4-2-3-5-14(11)24-10-16(23)25-9-13-8-15(22)21-18(19-13)26-17(20-21)12-6-7-12/h2-5,8,12H,6-7,9-10H2,1H3
  • InChiKey: VTLVYQXMFARIGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-methylphenoxy)acetic acid (2-cyclopropyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl ester
  • 2-(2-methylphenoxy)acetic acid (2-cyclopropyl-5-keto-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl ester
  • (2-cyclopropyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methyl 2-(2-methylphenoxy)ethanoate
  • G265-0333
  • NCGC00129784-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0057 0.0868 0.9091
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Schistosoma mansoni tyrosine kinase 0.007 0.1384 0.1432
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0926 0.0875
Echinococcus granulosus epidermal growth factor receptor 0.0092 0.2326 0.226
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0236 0.8311 0.8311
Onchocerca volvulus 0.0059 0.0918 0.3619
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0059 0.0918 0.0918
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0059 0.0918 0.0918
Loa Loa (eye worm) UNCoordinated family member 0.0059 0.0918 0.0868
Brugia malayi Immunoglobulin I-set domain containing protein 0.01 0.2633 0.4433
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0139
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.4001 0.6785
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.107 1
Echinococcus granulosus fibronectin type III domain-containing protein 0.0059 0.0918 0.0841
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0926 0.0926
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0039 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0093 0.2356 0.2314
Schistosoma mansoni tyrosine kinase 0.0073 0.1532 0.1586
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.107 1
Onchocerca volvulus 0.0093 0.2356 0.9648
Schistosoma mansoni roundabout 0.0041 0.0193 0.02
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.0918 0.1484
Schistosoma mansoni neuroglian 0.01 0.2633 0.2725
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.107 0.0994
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Echinococcus multilocularis usherin 0.0059 0.0918 0.0918
Echinococcus multilocularis Netrin receptor DCC 0.0059 0.0918 0.0918
Echinococcus multilocularis tyrosine protein kinase Srms 0.0065 0.1204 0.1204
Echinococcus multilocularis tyrosine protein kinase otk 0.0041 0.0193 0.0193
Onchocerca volvulus 0.0059 0.0918 0.3619
Loa Loa (eye worm) SRC-1 0.0073 0.1532 0.1485
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0139
Brugia malayi hypothetical protein 0.0059 0.0918 0.1484
Schistosoma mansoni tyrosine kinase 0.007 0.1384 0.1432
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.01 0.2633 0.2633
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0073 0.1532 0.1532
Onchocerca volvulus 0.0093 0.2356 0.9648
Echinococcus granulosus epidermal growth factor receptor 0.0092 0.2326 0.226
Echinococcus granulosus roundabout 2 0.01 0.2633 0.2571
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.1204 0.1204
Echinococcus multilocularis neuroglian 0.01 0.2633 0.2633
Brugia malayi Tyrosine-protein kinase abl-1 0.0152 0.4805 0.8167
Schistosoma mansoni titin 0.0093 0.2356 0.2438
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0858 0.138
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0065 0.1195 0.1195
Loa Loa (eye worm) TK protein kinase 0.0057 0.0868 0.0817
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.2356 0.3957
Echinococcus multilocularis epidermal growth factor receptor 0.0092 0.2326 0.2326
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0193 0.0237
Echinococcus granulosus titin 0.0095 0.244 0.2376
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0065 0.1204 0.1129
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.0918 0.0868
Schistosoma mansoni septate junction protein 0.0041 0.0193 0.02
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.0918 0.1484
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Brugia malayi Furin-like cysteine rich region family protein 0.0092 0.2326 0.3904
Loa Loa (eye worm) hypothetical protein 0.0062 0.1042 0.0993
Schistosoma mansoni septate junction protein 0.0041 0.0193 0.02
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.0918 0.1484
Schistosoma mansoni cell adhesion molecule 0.0041 0.0193 0.02
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0139
Schistosoma mansoni tyrosine kinase 0.0092 0.2326 0.2407
Onchocerca volvulus 0.0095 0.244 1
Echinococcus multilocularis epidermal growth factor receptor 0.0092 0.2326 0.2326
Trypanosoma brucei protein kinase, putative 0.0059 0.0926 0.0487
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0193 0.0237
Echinococcus granulosus tyrosine protein kinase Blk 0.0065 0.1204 0.1129
Brugia malayi Peroxidasin 0.0041 0.0193 0.0237
Brugia malayi Lethal protein 805 0.0059 0.0918 0.1484
Entamoeba histolytica protein kinase, putative 0.0059 0.0926 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0139
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0059 0.0918 0.1484
Schistosoma mansoni hypothetical protein 0.0059 0.0918 0.095
Echinococcus multilocularis titin 0.0059 0.0918 0.0918
Echinococcus granulosus protein kinase shaggy 0.0059 0.0926 0.0848
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0092 0.2326 0.226
Loa Loa (eye worm) myotactin form A 0.0059 0.0918 0.0868
Echinococcus multilocularis anosmin 1 0.0059 0.0918 0.0918
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.1532 0.1532
Echinococcus multilocularis Fibronectin, type III 0.0059 0.0918 0.0918
Echinococcus granulosus usherin 0.0059 0.0918 0.0841
Echinococcus granulosus Fibronectin type III 0.0059 0.0918 0.0841
Onchocerca volvulus 0.0059 0.0918 0.3619
Schistosoma mansoni tyrosine kinase 0.0039 0.0084 0.0087
Echinococcus multilocularis tyrosine protein kinase Blk 0.0065 0.1204 0.1204
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0041 0.0193 0.0193
Brugia malayi SRC-1 0.0073 0.1532 0.254
Echinococcus granulosus Netrin receptor DCC 0.0059 0.0918 0.0841
Echinococcus granulosus hemicentin 1 0.0041 0.0193 0.011
Echinococcus granulosus roundabout 2 0.012 0.3483 0.3427
Schistosoma mansoni hypothetical protein 0.0059 0.0918 0.095
Echinococcus granulosus cell adhesion molecule 0.0059 0.0918 0.0841
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0059 0.0918 0.0918
Loa Loa (eye worm) TK/EGFR protein kinase 0.0092 0.2326 0.2283
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.107 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.107 0.102
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0093 0.2356 0.2314
Brugia malayi plexin A 0.0045 0.0344 0.0496
Echinococcus granulosus neuroglian 0.01 0.2633 0.2571
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0289 0.03
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0057 0.0858 0.0858
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.01 0.2633 0.2571
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.2356 0.3957
Schistosoma mansoni cell adhesion molecule 0.0093 0.2356 0.2438
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.107 0.0994
Echinococcus granulosus tyrosine protein kinase HCK 0.0057 0.0868 0.079
Brugia malayi Immunoglobulin I-set domain containing protein 0.0095 0.244 0.4101
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.107 1
Schistosoma mansoni nephrin 0.01 0.2633 0.2725
Echinococcus granulosus G1Y162 protein 0.0059 0.0918 0.0841
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.244 0.2525
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0193 0.0237
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0926 0.0958
Brugia malayi myotactin form A 0.0059 0.0918 0.1484
Schistosoma mansoni ephrin receptor 0.0081 0.186 0.1925
Brugia malayi MAP kinase sur-1 0.0062 0.107 0.1744
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0059 0.0918 0.1484
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.107 1
Echinococcus granulosus Netrin receptor DCC 0.0059 0.0918 0.0841
Echinococcus multilocularis tyrosine protein kinase HCK 0.0057 0.0868 0.0868
Onchocerca volvulus 0.0059 0.0926 0.365
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0926 0.0926
Schistosoma mansoni plexin 0.0038 0.0055 0.0057
Schistosoma mansoni hemicentin 0.0093 0.2356 0.2438
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0059 0.0918 0.1484
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0236 0.8311 0.8297
Echinococcus granulosus insulin receptor 0.0177 0.5871 0.5836
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0059 0.0918 0.0841
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0193 0.0139
Schistosoma mansoni tyrosine kinase 0.0177 0.5871 0.6075
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.107 1
Brugia malayi protein-tyrosine kinase 0.0065 0.1204 0.1976
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.107 0.1107
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0546 0.0844
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0039 0.0084 0.0087
Schistosoma mansoni tyrosine kinase 0.007 0.1384 0.1432
Loa Loa (eye worm) projectin 0.0093 0.2356 0.2314
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.01 0.2633 0.2592
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0926 0.0875
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.107 1
Echinococcus granulosus contactin 0.01 0.2633 0.2571
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0926 0.5
Echinococcus granulosus plexin a4 0.0045 0.0344 0.0262
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0073 0.1532 0.1532
Echinococcus granulosus tyrosine protein kinase Src64B 0.0073 0.1532 0.146
Brugia malayi Immunoglobulin I-set domain containing protein 0.01 0.2633 0.4433
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0059 0.0918 0.0918
Schistosoma mansoni cell adhesion molecule 0.0093 0.2356 0.2438
Echinococcus multilocularis hemicentin 1 0.0041 0.0193 0.0193
Brugia malayi Protein kinase domain containing protein 0.0108 0.2965 0.5003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.1532 0.1532
Echinococcus granulosus nephrin 0.0093 0.2356 0.2291
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.0918 0.0868
Echinococcus granulosus tyrosine protein kinase otk 0.0041 0.0193 0.011
Brugia malayi Prion-like- 0.0041 0.0193 0.0237
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.01 0.2633 0.2633
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0193 0.0237
Brugia malayi SPRY domain containing protein 0.0059 0.0918 0.1484
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Brugia malayi myotactin form B 0.0059 0.0918 0.1484
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0059 0.0918 0.095
Echinococcus granulosus peroxidasin 0.0041 0.0193 0.011
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Schistosoma mansoni hypothetical protein 0.0043 0.0289 0.03
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.1768 0.2945
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0926 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0075 0.1616 0.1545
Echinococcus multilocularis contactin neuroglian septate junction protein 0.01 0.2633 0.2633
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0059 0.0918 0.0918
Schistosoma mansoni tyrosine kinase 0.0268 0.9664 1
Echinococcus granulosus neuroglian 0.0055 0.0766 0.0687
Echinococcus granulosus twitchin 0.0057 0.0849 0.0772
Echinococcus multilocularis plexin a4 0.0045 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0093 0.2356 0.2314
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0095 0.244 0.2398
Loa Loa (eye worm) plexin A 0.0045 0.0344 0.029
Loa Loa (eye worm) hypothetical protein 0.01 0.2633 0.2592
Loa Loa (eye worm) TK protein kinase 0.0057 0.0858 0.0807
Echinococcus multilocularis peroxidasin 0.0041 0.0193 0.0193
Brugia malayi Lethal protein 805 0.0059 0.0918 0.1484
Schistosoma mansoni factor for adipocyte differentiation 0.0059 0.0918 0.095
Schistosoma mansoni myosin-binding protein-related 0.0093 0.2356 0.2438
Echinococcus multilocularis c src tyrosine kinase 0.0039 0.0084 0.0084
Schistosoma mansoni titin 0.0095 0.244 0.2525
Schistosoma mansoni tyrosine kinase 0.0039 0.0084 0.0087
Schistosoma mansoni cell adhesion molecule 0.01 0.2633 0.2725
Echinococcus multilocularis insulin receptor 0.0177 0.5871 0.5871
Loa Loa (eye worm) hypothetical protein 0.0079 0.1768 0.1722
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0073 0.1532 0.1532
Loa Loa (eye worm) hypothetical protein 0.0079 0.1768 0.1722
Loa Loa (eye worm) hypothetical protein 0.0062 0.1042 0.0993
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0065 0.1195 0.1146
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0093 0.2356 0.2314
Schistosoma mansoni protein tyrosine phosphatase 0.0059 0.0918 0.095
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.1532 0.146
Onchocerca volvulus 0.0059 0.0918 0.3619
Onchocerca volvulus 0.0059 0.0918 0.3619
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.2356 0.3957
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0276 1 1
Loa Loa (eye worm) CAMK protein kinase 0.0095 0.244 0.2398
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.2356 0.3957
Echinococcus multilocularis neuroglian 0.0055 0.0766 0.0766
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0041 0.0193 0.0578
Echinococcus multilocularis tyrosine protein kinase Abl 0.0132 0.4001 0.4001
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.0918 0.1484
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0289 0.0207
Schistosoma mansoni titin 0.0059 0.0918 0.095
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0926 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0139
Brugia malayi Protein kinase domain containing protein 0.0177 0.5871 1
Echinococcus granulosus anosmin 1 0.0059 0.0918 0.0841
Brugia malayi Fibronectin type III domain containing protein 0.0079 0.1768 0.2945
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.107 1
Echinococcus multilocularis roundabout 2 0.012 0.3483 0.3483
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0193 0.0237
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.1532 0.146
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0059 0.0918 0.095
Echinococcus multilocularis titin 0.0095 0.244 0.244
Echinococcus granulosus tyrosine protein kinase Src42A 0.0073 0.1532 0.146
Schistosoma mansoni nephrin 0.0113 0.3206 0.3317
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0073 0.1532 0.146
Onchocerca volvulus 0.0059 0.0918 0.3619
Schistosoma mansoni hypothetical protein 0.0093 0.2356 0.2438
Echinococcus multilocularis transfer RNA-Phe 0.0093 0.2356 0.2356
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0926 0.0848
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0093 0.2356 0.2314
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0139
Echinococcus multilocularis cell adhesion molecule 0.0059 0.0918 0.0918
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0041 0.0193 0.02
Echinococcus granulosus tyrosine kinase 0.0065 0.1204 0.1129
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.107 0.107
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.1532 0.1532
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Brugia malayi intracellular kinase 0.0059 0.0926 0.1497
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0073 0.1532 0.1532
Loa Loa (eye worm) lethal protein 805 0.0059 0.0918 0.0868
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0059 0.0918 0.0841
Schistosoma mansoni factor for adipocyte differentiation 0.0059 0.0918 0.095
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0059 0.0918 0.0918
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.0918 0.1484
Echinococcus multilocularis anosmin 1 0.0059 0.0918 0.0918
Echinococcus granulosus roundabout 2 0.01 0.2633 0.2571
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0093 0.2356 0.2291
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.0918 0.0868
Loa Loa (eye worm) hypothetical protein 0.0079 0.1768 0.1722
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0193 0.0237
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.107 1
Echinococcus multilocularis Netrin receptor DCC 0.0059 0.0918 0.0918
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Echinococcus granulosus anosmin 1 0.0059 0.0918 0.0841
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0059 0.0918 0.0841
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.2356 0.3957
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.107 1
Echinococcus multilocularis roundabout 2 0.01 0.2633 0.2633
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.2356 0.3957
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Schistosoma mansoni tyrosine kinase 0.0092 0.2326 0.2407
Loa Loa (eye worm) hypothetical protein 0.0117 0.3336 0.3299
Loa Loa (eye worm) TK/INSR protein kinase 0.0177 0.5871 0.5848
Schistosoma mansoni cell adhesion molecule 0.0086 0.2045 0.2116
Brugia malayi hypothetical protein 0.0079 0.1768 0.2945
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0926 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Schistosoma mansoni tyrosine kinase 0.0073 0.1532 0.1586
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.107 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0073 0.1532 0.146
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0102 0.2717 0.2677
Brugia malayi Immunoglobulin I-set domain containing protein 0.01 0.2633 0.4433
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0263 0.018
Schistosoma mansoni titin 0.0041 0.0193 0.02
Echinococcus multilocularis hemicentin 1 0.0041 0.0193 0.0193
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.01 0.2633 0.2633
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0059 0.0918 0.095
Brugia malayi Protein-tyrosine phosphatase 0.0059 0.0918 0.1484
Schistosoma mansoni tripartite motif protein trim9 0.0059 0.0918 0.095
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0065 0.1195 0.112
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0059 0.0918 0.095
Echinococcus granulosus titin 0.0095 0.244 0.2376
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0926 0.0487
Loa Loa (eye worm) TK protein kinase 0.0065 0.1204 0.1155
Onchocerca volvulus 0.0059 0.0918 0.3619
Schistosoma mansoni tyrosine kinase 0.0064 0.1135 0.1174
Schistosoma mansoni tyrosine kinase 0.0092 0.2326 0.2407
Echinococcus multilocularis anosmin 1 0.0059 0.0918 0.0918
Schistosoma mansoni factor for adipocyte differentiation 0.0059 0.0918 0.095
Loa Loa (eye worm) TK/ABL protein kinase 0.0276 1 1
Brugia malayi protein unc-22 0.0095 0.244 0.4101
Onchocerca volvulus 0.0059 0.0918 0.3619
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0139
Trypanosoma brucei protein kinase, putative 0.0062 0.107 1
Echinococcus granulosus Fibronectin type III domain containing protein 0.0059 0.0918 0.0841
Echinococcus granulosus anosmin 1 0.0059 0.0918 0.0841
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0059 0.0918 0.0841
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.107 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.107 1
Schistosoma mansoni cell adhesion molecule 0.01 0.2633 0.2725
Echinococcus granulosus EG95 0.0059 0.0918 0.0841
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0073 0.1532 0.1532
Loa Loa (eye worm) TK/KIN16 protein kinase 0.005 0.0546 0.0494
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.1532 0.146
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.0918 0.0868
Onchocerca volvulus 0.0059 0.0918 0.3619
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0073 0.1532 0.1532
Brugia malayi hypothetical protein 0.0043 0.0289 0.0403
Onchocerca volvulus 0.0059 0.0918 0.3619
Loa Loa (eye worm) hypothetical protein 0.0059 0.0918 0.0868
Echinococcus granulosus lachesin 0.0041 0.0193 0.011
Loa Loa (eye worm) TK/ROR protein kinase 0.0057 0.0858 0.0807
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0926 0.0487
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.1195 0.196
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0193 0.0139
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.01 0.2633 0.2725
Echinococcus multilocularis lachesin 0.0041 0.0193 0.0193
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.107 0.107
Onchocerca volvulus Tyrosine kinase homolog 0.0057 0.0858 0.3365
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0057 0.0858 0.078
Onchocerca volvulus 0.0059 0.0918 0.3619
Loa Loa (eye worm) hypothetical protein 0.0085 0.2023 0.1979
Echinococcus multilocularis roundabout 2 0.01 0.2633 0.2633
Schistosoma mansoni tyrosine kinase 0.0177 0.5871 0.6075

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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