Detailed information for compound 1447175

Basic information

Technical information
  • TDR Targets ID: 1447175
  • Name: 7-[[6,7-dimethoxy-2-(3-methoxybenzoyl)-3,4-di hydro-1H-isoquinolin-1-yl]methoxy]-4-methylch romen-2-one
  • MW: 515.554 | Formula: C30H29NO7
  • H donors: 0 H acceptors: 2 LogP: 4.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2c(cc1OC)CCN(C2COc1ccc2c(c1)oc(=O)cc2C)C(=O)c1cccc(c1)OC
  • InChi: 1S/C30H29NO7/c1-18-12-29(32)38-26-15-22(8-9-23(18)26)37-17-25-24-16-28(36-4)27(35-3)14-19(24)10-11-31(25)30(33)20-6-5-7-21(13-20)34-2/h5-9,12-16,25H,10-11,17H2,1-4H3
  • InChiKey: HAGPZXLMAOAYBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[[6,7-dimethoxy-2-(3-methoxybenzoyl)-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-chromen-2-one
  • 7-[[6,7-dimethoxy-2-[(3-methoxyphenyl)-oxomethyl]-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-2-chromenone
  • 7-[[6,7-dimethoxy-2-(3-methoxybenzoyl)-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-coumarin
  • 7-[[6,7-dimethoxy-2-(3-methoxyphenyl)carbonyl-3,4-dihydro-1H-isoquinolin-1-yl]methoxy]-4-methyl-chromen-2-one
  • C199-0083
  • NCGC00104921-01
  • EU-0056572

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Brugia malayi SH2 domain containing protein 0.0057 0.0311 0.0606
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0417 0.5
Echinococcus granulosus c4b binding protein beta chain 0.0096 0.1187 0.118
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0203 0.3593 0.3588
Brugia malayi hypothetical protein 0.0057 0.0311 0.0606
Echinococcus multilocularis insulin growth factor binding 0.0083 0.0894 0.0887
Loa Loa (eye worm) hypothetical protein 0.0208 0.3702 0.3697
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Echinococcus multilocularis neuroglian 0.0203 0.3593 0.3588
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.1148 0.1141
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.3401 0.3495
Brugia malayi Animal haem peroxidase family protein 0.0083 0.0894 0.1773
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0071 0.0617 0.061
Echinococcus granulosus tyrosine protein kinase shark 0.0057 0.0311 0.0304
Echinococcus granulosus anosmin 1 0.011 0.1504 0.1498
Schistosoma mansoni tyrosine kinase 0.0188 0.3245 0.3334
Echinococcus granulosus insulin growth factor binding 0.0083 0.0894 0.0887
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.011 0.1504 0.1498
Onchocerca volvulus 0.011 0.1504 0.2447
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0057 0.0311 1
Echinococcus multilocularis 0.0083 0.0894 0.0887
Brugia malayi Myb-like DNA-binding domain containing protein 0.0083 0.0894 0.1773
Schistosoma mansoni hemicentin 0.0193 0.3374 0.3467
Onchocerca volvulus 0.011 0.1504 0.2447
Trypanosoma brucei protein kinase, putative 0.0055 0.0266 0.1635
Echinococcus multilocularis cell adhesion molecule 0.011 0.1504 0.1498
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1148 0.9666
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1148 0.5
Toxoplasma gondii rhoptry neck protein RON1 0.0096 0.1187 1
Echinococcus granulosus anosmin 1 0.011 0.1504 0.1498
Onchocerca volvulus 0.0096 0.1187 0.1797
Onchocerca volvulus 0.011 0.1504 0.2447
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0266 0.5
Echinococcus granulosus roundabout 2 0.0245 0.4531 0.4527
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.011 0.1504 0.1498
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0266 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0193 0.3374 0.3369
Schistosoma mansoni cell adhesion molecule 0.0193 0.3374 0.3467
Brugia malayi Protein kinase domain containing protein 0.0057 0.0311 0.0606
Echinococcus granulosus EG95 0.011 0.1504 0.1498
Echinococcus granulosus G1Y162 protein 0.011 0.1504 0.1498
Entamoeba histolytica tyrosin kinase, putative 0.005 0.0149 0.4797
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0083 0.0894 0.0887
Echinococcus multilocularis tyrosine kinase 0.0057 0.0311 0.0304
Schistosoma mansoni hypothetical protein 0.0193 0.3374 0.3467
Schistosoma mansoni tyrosine kinase 0.0226 0.41 0.4219
Onchocerca volvulus 0.0096 0.1187 0.1797
Loa Loa (eye worm) hypothetical protein 0.0094 0.1148 0.1141
Echinococcus multilocularis lachesin 0.0093 0.1113 0.1106
Brugia malayi Protein kinase domain containing protein 0.0226 0.41 0.8183
Echinococcus multilocularis peroxidasin 0.0093 0.1116 0.1109
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0193 0.3374 0.3369
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.011 0.1504 0.1532
Loa Loa (eye worm) hypothetical protein 0.0093 0.1113 0.1106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0227 0.4126 0.8235
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0144 0.2257 0.2251
Loa Loa (eye worm) hypothetical protein 0.0135 0.2051 0.2045
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1504 1
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Schistosoma mansoni tyrosine kinase 0.0226 0.41 0.4219
Onchocerca volvulus 0.011 0.1504 0.2447
Echinococcus granulosus Fibronectin type III 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Brugia malayi hypothetical protein 0.0096 0.1187 0.2358
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0266 0.5
Brugia malayi Leucine Rich Repeat family protein 0.0083 0.0897 0.1778
Echinococcus granulosus titin 0.0195 0.3401 0.3396
Onchocerca volvulus 0.0148 0.2344 0.4171
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.1113 0.221
Brugia malayi Tyrosine-protein kinase abl-1 0.0236 0.4322 0.8626
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0417 0.0409
Onchocerca volvulus Peroxidasin homolog 0.0083 0.0894 0.1196
Brugia malayi Immunoglobulin I-set domain containing protein 0.0203 0.3593 0.7168
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.1113 0.221
Schistosoma mansoni cell adhesion molecule 0.0093 0.1113 0.1127
Brugia malayi Lethal protein 805 0.011 0.1504 0.2992
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Onchocerca volvulus 0.0083 0.0897 0.1202
Brugia malayi hypothetical protein 0.0096 0.1187 0.2358
Onchocerca volvulus 0.0083 0.0894 0.1196
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0921 0.0929
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0336 0.658 0.6577
Plasmodium vivax apical sushi protein, putative 0.0096 0.1187 1
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0083 0.0897 0.089
Echinococcus granulosus lachesin 0.0093 0.1113 0.1106
Onchocerca volvulus Putative titin 0.0083 0.0894 0.1196
Loa Loa (eye worm) SRC-1 0.0071 0.0617 0.061
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Brugia malayi pregnancy-associated plasma protein-A 0.0096 0.1187 0.2358
Echinococcus multilocularis tumor protein p63 0.0408 0.8201 0.82
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0266 0.1635
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0071 0.0617 0.061
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.006 0.0368 0.036
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Brugia malayi Prion-like- 0.0083 0.0894 0.1773
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Brugia malayi Furin-like cysteine rich region family protein 0.0261 0.4905 0.9792
Onchocerca volvulus 0.0195 0.3401 0.6338
Brugia malayi protein-tyrosine kinase 0.0057 0.0311 0.0606
Brugia malayi Disorganized muscle protein 1 0.0083 0.0894 0.1773
Echinococcus multilocularis neuroglian 0.0125 0.1832 0.1826
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0083 0.0897 0.089
Echinococcus granulosus tyrosine protein kinase Src42A 0.0071 0.0617 0.061
Schistosoma mansoni receptor protein tyrosine phosphatase 0.011 0.1504 0.1532
Echinococcus multilocularis hemicentin 1 0.0093 0.1113 0.1106
Schistosoma mansoni cell adhesion molecule 0.0203 0.3593 0.3694
Echinococcus multilocularis 0.0067 0.0527 0.052
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0266 0.1635
Echinococcus granulosus c src tyrosine kinase 0.0071 0.0617 0.061
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0071 0.0617 0.061
Loa Loa (eye worm) lethal protein 805 0.011 0.1504 0.1498
Brugia malayi protein unc-22 0.0195 0.3401 0.6784
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2442 0.4868
Loa Loa (eye worm) CAMK protein kinase 0.0195 0.3401 0.3396
Brugia malayi Fibronectin type III domain containing protein 0.011 0.1504 0.2992
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0303 0.0289
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Loa Loa (eye worm) animal heme peroxidase 0.0083 0.0894 0.0887
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0083 0.0894 0.0887
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0083 0.0894 0.0887
Onchocerca volvulus 0.0083 0.0894 0.1196
Brugia malayi Fibronectin type III domain containing protein 0.011 0.1504 0.2992
Onchocerca volvulus 0.011 0.1504 0.2447
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.0304
Echinococcus granulosus Netrin receptor DCC 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0093 0.1113 0.1106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Echinococcus granulosus insulin receptor 0.0226 0.41 0.4096
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0071 0.0617 0.061
Brugia malayi Fibronectin type III domain containing protein 0.0152 0.2442 0.4868
Brugia malayi SPRY domain containing protein 0.011 0.1504 0.2992
Schistosoma mansoni hypothetical protein 0.0083 0.0894 0.0901
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0071 0.0617 0.061
Echinococcus granulosus anosmin 1 0.011 0.1504 0.1498
Schistosoma mansoni tyrosine kinase 0.0071 0.0617 0.0614
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.011 0.1504 0.1498
Schistosoma mansoni titin 0.0083 0.0894 0.0901
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.011 0.1504 0.1532
Echinococcus granulosus tyrosine kinase 0.0057 0.0311 0.0304
Echinococcus granulosus tumor protein p63 0.0408 0.8201 0.82
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0083 0.0894 0.0901
Onchocerca volvulus 0.0193 0.3374 0.6282
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0417 0.0409
Onchocerca volvulus 0.011 0.1504 0.2447
Onchocerca volvulus 0.0083 0.0894 0.1196
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.1148 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0072 0.0644 0.0637
Brugia malayi Sushi domain 0.0096 0.1187 0.2358
Echinococcus granulosus Down syndrome cell adhesion molecule 0.012 0.1723 0.1717
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Echinococcus granulosus tyrosine protein kinase Fyn 0.0071 0.0617 0.061
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0368 0.0356
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0204 0.362 0.3615
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Echinococcus granulosus tyrosine protein kinase Blk 0.0057 0.0311 0.0304
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0096 0.1187 0.118
Echinococcus granulosus fibronectin type III domain-containing protein 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Loa Loa (eye worm) myotactin form A 0.011 0.1504 0.1498
Loa Loa (eye worm) TK/EGFR protein kinase 0.0261 0.4905 0.4901
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.1113 0.221
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0044 0.0024 0.0016
Schistosoma mansoni hypothetical protein 0.0083 0.0894 0.0901
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.011 0.1504 0.1498
Schistosoma mansoni tyrosine kinase 0.0071 0.0617 0.0614
Brugia malayi hypothetical protein 0.0096 0.1187 0.2358
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Schistosoma mansoni titin 0.0093 0.1113 0.1127
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.011 0.1504 0.1498
Brugia malayi myotactin form A 0.011 0.1504 0.2992
Echinococcus granulosus activin receptor type 0.0044 0.0024 0.0016
Echinococcus multilocularis anosmin 1 0.011 0.1504 0.1498
Brugia malayi Peroxidasin 0.0093 0.1116 0.2216
Echinococcus multilocularis titin 0.0083 0.0894 0.0887
Echinococcus multilocularis anosmin 1 0.011 0.1504 0.1498
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1148 0.5
Brugia malayi hypothetical protein 0.0096 0.1187 0.2358
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.011 0.1504 0.1498
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0071 0.0617 0.0614
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0144 0.2257 0.2251
Brugia malayi Protein kinase domain containing protein 0.0057 0.0311 0.0606
Brugia malayi hypothetical protein 0.011 0.1504 0.2992
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.3374 0.6731
Onchocerca volvulus 0.011 0.1504 0.2447
Schistosoma mansoni tyrosine kinase 0.0071 0.0617 0.0614
Onchocerca volvulus Netrin receptor homolog 0.0083 0.0894 0.1196
Echinococcus granulosus tyrosine kinase 0.0057 0.0311 0.0304
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Brugia malayi Protein kinase domain containing protein 0.0057 0.0311 0.0606
Echinococcus granulosus titin 0.0083 0.0894 0.0887
Loa Loa (eye worm) TK/ROR protein kinase 0.0126 0.1867 0.186
Schistosoma mansoni hypothetical protein 0.0083 0.0894 0.0901
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1148 0.5
Schistosoma mansoni hypothetical protein 0.0083 0.0894 0.0901
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0071 0.0617 0.061
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Loa Loa (eye worm) TK protein kinase 0.0227 0.4126 0.4122
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Echinococcus granulosus nephrin 0.0193 0.3374 0.3369
Schistosoma mansoni titin 0.0193 0.3374 0.3467
Schistosoma mansoni tyrosine kinase 0.0144 0.2257 0.2311
Loa Loa (eye worm) hypothetical protein 0.0203 0.3593 0.3588
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Echinococcus granulosus neuroglian 0.0125 0.1832 0.1826
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.1113 0.221
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.3374 0.6731
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Echinococcus multilocularis transfer RNA-Phe 0.0193 0.3374 0.3369
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.1148 0.1164
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0057 0.0311 0.0304
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1148 0.5
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Schistosoma mansoni nephrin 0.0203 0.3593 0.3694
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0203 0.3593 0.3588
Onchocerca volvulus 0.0083 0.0894 0.1196
Echinococcus granulosus epidermal growth factor receptor 0.0261 0.4905 0.4901
Onchocerca volvulus 0.0193 0.3374 0.6282
Echinococcus granulosus cell adhesion molecule 0.011 0.1504 0.1498
Brugia malayi hypothetical protein 0.0096 0.1187 0.2358
Onchocerca volvulus 0.011 0.1504 0.2447
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0417 0.5
Onchocerca volvulus 0.0096 0.1187 0.1797
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0083 0.0894 0.0887
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.012 0.1723 0.1717
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0311 0.0304
Schistosoma mansoni neuroglian 0.0203 0.3593 0.3694
Echinococcus granulosus hemicentin 1 0.0093 0.1113 0.1106
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.012 0.1723 0.1717
Schistosoma mansoni hypothetical protein 0.0083 0.0894 0.0901
Echinococcus granulosus titin 0.0083 0.0894 0.0887
Echinococcus granulosus titin 0.0083 0.0894 0.0887
Schistosoma mansoni tripartite motif protein trim9 0.011 0.1504 0.1532
Brugia malayi Prion-like- 0.0083 0.0894 0.1773
Brugia malayi Immunoglobulin I-set domain containing protein 0.0203 0.3593 0.7168
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.3374 0.6731
Echinococcus granulosus tyrosine protein kinase Srms 0.0057 0.0311 0.0304
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.3374 0.6731
Echinococcus granulosus tyrosine protein kinase otk 0.0093 0.1113 0.1106
Onchocerca volvulus 0.0096 0.1187 0.1797
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.1113 0.221
Schistosoma mansoni roundabout 0.0093 0.1113 0.1127
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.3374 0.6731
Echinococcus granulosus leucine rich repeat containing protein 4 0.0083 0.0894 0.0887
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0083 0.0894 0.0887
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.011 0.1504 0.1498
Brugia malayi Protein kinase domain containing protein 0.0057 0.0311 0.0606
Brugia malayi myotactin form B 0.011 0.1504 0.2992
Loa Loa (eye worm) hypothetical protein 0.0152 0.2442 0.2436
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0057 0.0311 0.0304
Schistosoma mansoni factor for adipocyte differentiation 0.011 0.1504 0.1532
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0266 0.5
Schistosoma mansoni ephrin receptor 0.0154 0.2477 0.2539
Loa Loa (eye worm) projectin 0.0193 0.3374 0.3369
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0242 0.4474 0.4469
Brugia malayi Tyrosine-protein kinase abl-1 0.0266 0.5009 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0203 0.3593 0.3588
Brugia malayi SH2 domain containing protein 0.0057 0.0311 0.0606
Echinococcus multilocularis tyrosine protein kinase Abl 0.0236 0.4322 0.4317
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0044 0.0024 0.0016
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0144 0.2257 0.2251
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Onchocerca volvulus 0.0083 0.0894 0.1196
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Brugia malayi SRC-1 0.0071 0.0617 0.1219
Schistosoma mansoni titin 0.0083 0.0894 0.0901
Brugia malayi Protein kinase domain containing protein 0.0116 0.1633 0.325
Brugia malayi Fibronectin type III domain containing protein 0.011 0.1504 0.2992
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.011 0.1504 0.2992
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.011 0.1504 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0203 0.3593 0.3588
Brugia malayi Prion-like- 0.0093 0.1113 0.221
Onchocerca volvulus 0.0096 0.1187 0.1797
Schistosoma mansoni nephrin related 0.0083 0.0894 0.0901
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0266 0.0259
Brugia malayi Fibronectin type III domain containing protein 0.011 0.1504 0.2992
Loa Loa (eye worm) hypothetical protein 0.0093 0.1113 0.1106
Echinococcus granulosus twitchin 0.0126 0.1859 0.1853
Brugia malayi Lethal protein 805 0.011 0.1504 0.2992
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0071 0.0617 0.061
Schistosoma mansoni tyrosine kinase 0.0057 0.0311 0.0297
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0266 0.1635
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Onchocerca volvulus 0.0096 0.1187 0.1797
Brugia malayi Protein-tyrosine phosphatase 0.011 0.1504 0.2992
Brugia malayi GCC2 and GCC3 family protein 0.0096 0.1187 0.2358
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Schistosoma mansoni protein tyrosine phosphatase 0.011 0.1504 0.1532
Onchocerca volvulus 0.0096 0.1187 0.1797
Echinococcus multilocularis usherin 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Echinococcus multilocularis titin 0.0083 0.0894 0.0887
Echinococcus granulosus usherin 0.011 0.1504 0.1498
Brugia malayi hypothetical protein 0.0152 0.2442 0.4868
Schistosoma mansoni septate junction protein 0.0093 0.1113 0.1127
Echinococcus multilocularis titin 0.0083 0.0894 0.0887
Echinococcus multilocularis tyrosine protein kinase Blk 0.0057 0.0311 0.0304
Schistosoma mansoni nephrin 0.0235 0.4312 0.4438
Echinococcus granulosus titin 0.0195 0.3401 0.3396
Onchocerca volvulus 0.011 0.1504 0.2447
Schistosoma mansoni factor for adipocyte differentiation 0.011 0.1504 0.1532
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Onchocerca volvulus 0.006 0.0368 0.0116
Echinococcus multilocularis anosmin 1 0.011 0.1504 0.1498
Echinococcus multilocularis tyrosine protein kinase Srms 0.0057 0.0311 0.0304
Brugia malayi Immunoglobulin I-set domain containing protein 0.0203 0.3593 0.7168
Echinococcus granulosus Netrin receptor DCC 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.0193 0.3374 0.3369
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.3374 0.6731
Onchocerca volvulus 0.0096 0.1187 0.1797
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1148 0.9666
Schistosoma mansoni slit 0.0083 0.0897 0.0904
Echinococcus multilocularis Fibronectin, type III 0.011 0.1504 0.1498
Toxoplasma gondii rhoptry neck protein RON9 0.0096 0.1187 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0266 0.0259
Echinococcus granulosus fibroblast growth factor receptor 4 0.0144 0.2257 0.2251
Echinococcus multilocularis tyrosine protein kinase otk 0.0093 0.1113 0.1106
Onchocerca volvulus 0.011 0.1504 0.2447
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Schistosoma mansoni hypothetical protein 0.011 0.1504 0.1532
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Brugia malayi MAP kinase sur-1 0.0055 0.0266 0.0517
Echinococcus multilocularis fibronectin type III domain-containing protein 0.011 0.1504 0.1498
Loa Loa (eye worm) TK/INSR protein kinase 0.0226 0.41 0.4096
Echinococcus granulosus peroxidasin 0.0093 0.1116 0.1109
Schistosoma mansoni titin 0.011 0.1504 0.1532
Schistosoma mansoni titin 0.0083 0.0894 0.0901
Loa Loa (eye worm) hypothetical protein 0.0051 0.0182 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0044 0.0024 0.0773
Onchocerca volvulus Tyrosine kinase homolog 0.0274 0.5186 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0203 0.3593 0.3588
Echinococcus multilocularis epidermal growth factor receptor 0.0188 0.3245 0.324
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Echinococcus multilocularis Netrin receptor DCC 0.011 0.1504 0.1498
Echinococcus multilocularis tyrosine protein kinase shark 0.0057 0.0311 0.0304
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.1148 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.1148 0.1141
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0083 0.0894 0.0887
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0203 0.3593 0.3694
Loa Loa (eye worm) hypothetical protein 0.0073 0.0661 0.0654
Schistosoma mansoni factor for adipocyte differentiation 0.011 0.1504 0.1532
Echinococcus granulosus neuroglian 0.0203 0.3593 0.3588
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0083 0.0894 0.0887
Loa Loa (eye worm) TK/ABL protein kinase 0.0488 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.011 0.1504 0.1532
Echinococcus granulosus Fibronectin type III domain containing protein 0.011 0.1504 0.1498
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0266 0.0259
Schistosoma mansoni myosin-binding protein-related 0.0193 0.3374 0.3467
Schistosoma mansoni hypothetical protein 0.011 0.1504 0.1532
Schistosoma mansoni tyrosine kinase 0.0071 0.0617 0.0614
Loa Loa (eye worm) one IG domain family member 0.0083 0.0894 0.0887
Echinococcus multilocularis Netrin receptor DCC 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.011 0.1504 0.2992
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Brugia malayi hypothetical protein 0.0096 0.1187 0.2358
Brugia malayi hypothetical protein 0.0096 0.1187 0.2358
Schistosoma mansoni c4b-binding protein beta chain 0.0096 0.1187 0.1204
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0266 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0083 0.0897 0.089
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Schistosoma mansoni cell adhesion molecule 0.0083 0.0894 0.0901
Leishmania major hypothetical protein, conserved 0.011 0.1504 1
Echinococcus granulosus C type lectin domian containing protein 0.0096 0.1187 0.118
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0093 0.1113 0.1645
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0126 0.1867 0.186
Schistosoma mansoni tyrosine kinase 0.0144 0.2273 0.2328
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1148 0.5
Echinococcus multilocularis insulin receptor 0.0226 0.41 0.4096
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0266 0.1635
Echinococcus multilocularis c src tyrosine kinase 0.0071 0.0617 0.061
Schistosoma mansoni tyrosine kinase 0.0261 0.4905 0.5052
Echinococcus granulosus contactin 0.0203 0.3593 0.3588
Echinococcus granulosus tyrosine protein kinase Src64B 0.0071 0.0617 0.061
Echinococcus multilocularis roundabout 2 0.0203 0.3593 0.3588
Echinococcus multilocularis down syndrome cell adhesion 0.0083 0.0894 0.0887
Schistosoma mansoni hypothetical protein 0.0083 0.0894 0.0901
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0193 0.3374 0.3369
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0266 0.0259
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.011 0.1504 0.1498
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0266 0.1635
Echinococcus multilocularis activin receptor type 0.0044 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0266 0.2081
Schistosoma mansoni tyrosine kinase 0.0188 0.3245 0.3334
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.0135 0.2051 0.2045
Echinococcus granulosus epidermal growth factor receptor 0.0188 0.3245 0.324
Brugia malayi Protein kinase domain containing protein 0.0057 0.0311 0.0606
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0193 0.3374 0.3369
Schistosoma mansoni tyrosine kinase 0.0057 0.0311 0.0297
Loa Loa (eye worm) TK protein kinase 0.0057 0.0311 0.0304
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0071 0.0617 0.061
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Schistosoma mansoni titin 0.0083 0.0894 0.0901
Onchocerca volvulus 0.0083 0.0894 0.1196
Loa Loa (eye worm) hypothetical protein 0.0152 0.2442 0.2436
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.011 0.1504 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Echinococcus granulosus down syndrome cell adhesion 0.0083 0.0894 0.0887
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Echinococcus granulosus tyrosine protein kinase Fyn 0.0071 0.0617 0.061
Loa Loa (eye worm) hypothetical protein 0.0093 0.1113 0.1106
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0188 0.3245 0.324
Loa Loa (eye worm) hypothetical protein 0.0107 0.143 0.1423
Onchocerca volvulus Peroxidasin homolog 0.0083 0.0897 0.1202
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Echinococcus multilocularis titin 0.011 0.1504 0.1498
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0057 0.0311 0.0304
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0149 0.4797
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0071 0.0617 0.061
Loa Loa (eye worm) hypothetical protein 0.0152 0.2442 0.2436
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0195 0.3401 0.3396
Echinococcus multilocularis hemicentin 1 0.0093 0.1113 0.1106
Loa Loa (eye worm) hypothetical protein 0.0093 0.1113 0.1106
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887
Brugia malayi kettin 0.0083 0.0894 0.1773
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0093 0.1113 0.1106
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.011 0.1504 1
Schistosoma mansoni tyrosine kinase 0.0474 0.9686 1
Echinococcus multilocularis roundabout 2 0.0203 0.3593 0.3588
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0083 0.0894 0.1773
Plasmodium falciparum apical sushi protein 0.0096 0.1187 1
Schistosoma mansoni septate junction protein 0.0093 0.1113 0.1127
Loa Loa (eye worm) disorganized muscle protein 1 0.0083 0.0894 0.0887
Brugia malayi Probable ClpP-like protease 0.0094 0.1148 0.2281
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0203 0.3593 0.3588
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0083 0.0894 0.0887
Loa Loa (eye worm) hypothetical protein 0.0093 0.1113 0.1106
Echinococcus granulosus roundabout 2 0.0203 0.3593 0.3588
Schistosoma mansoni cell adhesion molecule 0.0203 0.3593 0.3694
Echinococcus multilocularis C type lectin domian containing protein 0.0096 0.1187 0.118
Schistosoma mansoni tyrosine kinase 0.0144 0.2273 0.2328
Echinococcus multilocularis twitchin 0.0084 0.0921 0.0914
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0311 0.0304
Echinococcus multilocularis roundabout 2 0.0245 0.4531 0.4527
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0266 0.0251
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.011 0.1504 0.1498
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1148 0.9666
Schistosoma mansoni titin 0.0195 0.3401 0.3495
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0266 0.1635
Echinococcus multilocularis titin 0.0195 0.3401 0.3396
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.011 0.1504 0.2992
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0126 0.1867 0.186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0242 0.4474 0.893
Schistosoma mansoni tyrosine kinase 0.0136 0.2086 0.2134
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0897 0.1778
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0266 0.0259
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.1113 0.221
Schistosoma mansoni titin 0.0083 0.0894 0.0901
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.011 0.1504 0.1498
Brugia malayi Immunoglobulin I-set domain containing protein 0.0195 0.3401 0.6784
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0071 0.0617 0.061
Schistosoma mansoni tyrosine kinase 0.0144 0.2273 0.2328
Loa Loa (eye worm) UNCoordinated family member 0.011 0.1504 0.1498
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.1723 0.343
Echinococcus granulosus roundabout 2 0.0203 0.3593 0.3588
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0894 0.1773
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0488 1 1
Schistosoma mansoni cell adhesion molecule 0.0193 0.3374 0.3467
Echinococcus multilocularis Fibronectin type III domain containing protein 0.011 0.1504 0.1498
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0266 0.1635
Onchocerca volvulus 0.011 0.1504 0.2447
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0071 0.0617 0.061
Loa Loa (eye worm) hypothetical protein 0.0093 0.1113 0.1106
Loa Loa (eye worm) hypothetical protein 0.0193 0.3374 0.3369
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0093 0.1113 0.1127
Loa Loa (eye worm) hypothetical protein 0.0096 0.1187 0.118
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0051 0.0182 0.0174
Onchocerca volvulus 0.0083 0.0894 0.1196
Brugia malayi Fibronectin type III domain containing protein 0.011 0.1504 0.2992
Onchocerca volvulus 0.0096 0.1187 0.1797
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.011 0.1504 0.1498
Loa Loa (eye worm) hypothetical protein 0.0093 0.1116 0.1109
Echinococcus multilocularis c4b binding protein beta chain 0.0096 0.1187 0.118
Echinococcus multilocularis epidermal growth factor receptor 0.0261 0.4905 0.4901
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0071 0.0617 0.061
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0093 0.1113 0.1106
Onchocerca volvulus 0.0096 0.1187 0.1797
Schistosoma mansoni cell adhesion molecule 0.0162 0.2661 0.2729
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0071 0.0617 0.061
Echinococcus granulosus tyrosine protein kinase Fyn 0.0071 0.0617 0.061
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0336 0.658 0.6577
Brugia malayi Prion-like- 0.0083 0.0894 0.1773
Loa Loa (eye worm) hypothetical protein 0.0083 0.0894 0.0887

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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