TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 550.544 | Formula: C26H33Cl2N5O2S
H donors: 2 H acceptors: 3 LogP: 5.02 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc2c(c1)nccc2NCCCN1CCN(CC1)CCCNS(=O)(=O)c1cccc(c1C)Cl
InChi: 1S/C26H33Cl2N5O2S/c1-20-23(28)5-2-6-26(20)36(34,35)31-11-4-14-33-17-15-32(16-18-33)13-3-10-29-24-9-12-30-25-19-21(27)7-8-22(24)25/h2,5-9,12,19,31H,3-4,10-11,13-18H2,1H3,(H,29,30)
InChiKey: XNKPGMFQBZTOIF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	protein-tyrosine kinase	0.126144	0.00920146	0.013219
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.74502	0.1227	0.1227
Loa Loa (eye worm)	SH2 domain-containing protein	0.162187	0.0158115	0.0178169
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.126144	0.00920146	0.00920146
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.787759	0.130539	0.130539
Onchocerca volvulus		0.186414	0.0202546	0.0689282
Schistosoma mansoni	tyrosine kinase	0.312558	0.0433889	0.0433834
Brugia malayi	Src substrate cortactin	0.126144	0.00920146	0.013219
Onchocerca volvulus		0.129355	0.00979033	0.0137353
Trypanosoma cruzi	hypothetical protein, conserved	1.2496	0.215238	0.307695
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Echinococcus multilocularis	epidermal growth factor receptor	1.40103	0.243011	0.243011
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Brugia malayi	Protein kinase domain containing protein	0.186414	0.0202546	0.0290982
Onchocerca volvulus	Tyrosine kinase homolog	1.14896	0.196781	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.695334	0.113588	0.151973
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.126395	0.00924751	0.00924178
Schistosoma mansoni	sorbin	0.126144	0.00920146	0.00919572
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	1.6572	0.28999	0.416606
Echinococcus multilocularis	SH2 motif	0.129355	0.00979033	0.00979033
Loa Loa (eye worm)	TK protein kinase	0.48952	0.0758431	0.0854625
Giardia lamblia	Hypothetical protein	0.245756	0.0311377	0.0593232
Brugia malayi	Variant SH3 domain containing protein	0.255499	0.0329246	0.0473002
Schistosoma mansoni	cell adhesion molecule	0.116584	0.00744823	0.00744248
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.130215	0.00994806	0.00994233
Echinococcus multilocularis	serine protein kinase ATM	0.386535	0.0569559	0.0569559
Brugia malayi	FAT domain containing protein	0.161553	0.0156953	0.0225483
Brugia malayi	SH2 domain containing protein	0.129355	0.00979033	0.014065
Echinococcus multilocularis	nostrin	0.126144	0.00920146	0.00920146
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.129355	0.00979033	0.00979033
Echinococcus granulosus	expressed conserved protein	0.129355	0.00979033	0.00979033
Schistosoma mansoni	nck2/grb4	0.255499	0.0329246	0.032919
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	3.64557	0.654648	0.654648
Brugia malayi	Variant SH3 domain containing protein	0.126144	0.00920146	0.013219
Echinococcus granulosus	suppressor of cytokine signaling 7	0.129355	0.00979033	0.00979033
Schistosoma mansoni	tyrosine kinase	0.200878	0.0229073	0.0229017
Echinococcus multilocularis	SH2 motif	0.129355	0.00979033	0.00979033
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.126144	0.00920146	0.00920146
Loa Loa (eye worm)	phosphatidylinositol 3	0.245756	0.0311377	0.035087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.552811	0.0874503	0.11392
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	3.87147	0.696077	1
Brugia malayi	SH2 domain containing protein	0.129355	0.00979033	0.014065
Echinococcus granulosus	tyrosine kinase	0.186414	0.0202546	0.0202546
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.130215	0.00994806	0.00994806
Entamoeba histolytica	hypothetical protein	0.126144	0.00920146	0.00292539
Onchocerca volvulus		0.129355	0.00979033	0.0137353
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.129355	0.00979033	0.00979033
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.245756	0.0311377	0.0426311
Schistosoma mansoni	tyrosine kinase	0.481307	0.0743367	0.0743314
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.140779	0.0118854	0.0149121
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.386535	0.0569559	0.0569559
Schistosoma mansoni	eps8-related protein	0.126144	0.00920146	0.00919572
Trichomonas vaginalis	conserved hypothetical protein	0.407309	0.0607658	0.0750709
Echinococcus multilocularis	tyrosine protein kinase shark	0.186414	0.0202546	0.0202546
Schistosoma mansoni	GTPase activating protein	0.129355	0.00979033	0.0097846
Schistosoma mansoni	sorting nexin	0.126144	0.00920146	0.00919572
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.74502	0.1227	0.1227
Trichomonas vaginalis	PIKK family atypical protein kinase	0.695334	0.113588	0.151973
Brugia malayi	hypothetical protein	0.0930023	0.00312337	0.00448711
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.787759	0.130539	0.130539
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	3.64557	0.654648	0.654648
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Leishmania major	hypothetical protein, conserved	0.126144	0.00920146	0.0296514
Schistosoma mansoni	suppressor of cytokine signaling	0.129355	0.00979033	0.0097846
Echinococcus multilocularis	tyrosine protein kinase csk	0.0898902	0.00255264	0.00255264
Brugia malayi	Immunoglobulin I-set domain containing protein	1.22768	0.211219	0.303442
Echinococcus multilocularis	growth factor receptor bound protein 2	0.255499	0.0329246	0.0329246
Schistosoma mansoni	shc transforming protein	0.129355	0.00979033	0.0097846
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.705956	0.115536	0.115536
Echinococcus multilocularis	Spectrin alpha actinin	0.126145	0.00920154	0.00920154
Loa Loa (eye worm)	STAT protein	0.129355	0.00979033	0.0110321
Brugia malayi	Protein kinase domain containing protein	0.186414	0.0202546	0.0290982
Trichomonas vaginalis	PIKK family atypical protein kinase	0.245756	0.0311377	0.0319362
Entamoeba histolytica	hypothetical protein	0.245756	0.0311377	0.0347682
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.787759	0.130539	0.130534
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.245756	0.0311377	0.167987
Brugia malayi	Variant SH3 domain containing protein	0.130215	0.00994806	0.0142916
Echinococcus granulosus	Spectrin alpha actinin	0.126145	0.00920154	0.00920154
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.245756	0.0311377	0.167987
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.386535	0.0569559	0.0818241
Echinococcus multilocularis	tyrosine protein kinase csk	0.0898902	0.00255264	0.00255264
Brugia malayi	Variant SH3 domain containing protein	0.126144	0.00920146	0.013219
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.255499	0.0329246	0.0371005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.787759	0.130539	0.176651
Schistosoma mansoni	tyrosine kinase	0.718561	0.117848	0.117843
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.705956	0.115536	0.15481
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.787759	0.130539	0.185747
Schistosoma mansoni	tyrosine kinase	2.18911	0.387539	0.387536
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	1.3197	0.228094	0.327685
Schistosoma mansoni	tyrosine kinase	0.74502	0.1227	0.122695
Trichomonas vaginalis	PIKK family atypical protein kinase	0.62194	0.100128	0.132377
Echinococcus multilocularis	SH2 domain containing protein 7	0.129355	0.00979033	0.00979033
Echinococcus multilocularis	tyrosine protein kinase ABL1	2.31846	0.411262	0.411262
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.432399	0.0653671	0.536972
Echinococcus granulosus	expressed protein	0.126144	0.00920146	0.00920146
Trypanosoma brucei	conserved protein	0.126144	0.00920146	0.0338675
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Trichomonas vaginalis	PIKK family atypical protein kinase	0.695334	0.113588	0.151973
Echinococcus multilocularis	roundabout 2	0.135497	0.0109168	0.0109168
Schistosoma mansoni	fkbp-rapamycin associated protein	0.386535	0.0569559	0.0569504
Trichomonas vaginalis	PIKK family atypical protein kinase	0.640513	0.103534	0.137336
Brugia malayi	Peripheral plasma membrane protein CASK	0.126144	0.00920146	0.013219
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	2.9304	0.523489	0.748735
Echinococcus granulosus	tyrosine protein kinase Blk	0.618876	0.0995662	0.0995662
Brugia malayi	Variant SH3 domain containing protein	0.126144	0.00920146	0.013219
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.548088	0.086584	0.124389
Brugia malayi	Protein kinase domain containing protein	0.186414	0.0202546	0.0290982
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.713907	0.116995	0.446195
Entamoeba histolytica	BAR/SH3 domain containing protein	0.126144	0.00920146	0.00292539
Schistosoma mansoni	C-fyn	0.126144	0.00920146	0.00919572
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.548088	0.086584	0.0865788
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	1.3197	0.228094	0.326205
Entamoeba histolytica	hypothetical protein	0.386535	0.0569559	0.0722461
Echinococcus multilocularis	Zinc finger, PHD finger	0.705956	0.115536	0.115536
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.705956	0.115536	0.759927
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.386535	0.0569559	0.0798038
Echinococcus granulosus	tyrosine protein kinase Fyn	0.74502	0.1227	0.1227
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	1.3197	0.228094	0.228089
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.186414	0.0202546	0.0202546
Echinococcus granulosus	SH2 motif	0.129355	0.00979033	0.00979033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.548088	0.086584	0.112659
Echinococcus granulosus	SH2 motif	0.129355	0.00979033	0.00979033
Loa Loa (eye worm)	hypothetical protein	0.255499	0.0329246	0.0371005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.714365	0.117078	0.157054
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.74502	0.1227	0.1227
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.327022	0.0460416	0.0460416
Onchocerca volvulus		0.219245	0.0262758	0.100686
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.432399	0.0653671	0.0919141
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	3.25773	0.58352	0.836611
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.186414	0.0202546	0.0189702
Schistosoma mansoni	tyrosine kinase	0.77562	0.128312	0.128307
Loa Loa (eye worm)	hypothetical protein	0.115156	0.00718618	0.00809763
Plasmodium vivax	hypothetical protein, conserved	0.115156	0.00718618	0.0366636
Brugia malayi	Variant SH3 domain containing protein	0.129606	0.00983639	0.0141312
Loa Loa (eye worm)	phosphatidylinositol 3	4.91493	0.887443	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.74502	0.1227	0.1227
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	1.07394	0.183023	0.261313
Onchocerca volvulus		0.245756	0.0311377	0.12633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.548088	0.086584	0.112659
Loa Loa (eye worm)	phosphatidylinositol 3	0.245756	0.0311377	0.035087
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.705956	0.115536	0.165982
Echinococcus multilocularis		0.418362	0.0627929	0.0627929
Echinococcus multilocularis	tyrosine protein kinase Blk	0.618876	0.0995662	0.0995662
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.255499	0.0329246	0.0371005
Schistosoma mansoni	tyrosine kinase	0.345389	0.0494101	0.0494046
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.245756	0.0311377	0.249615
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.787759	0.130539	0.179059
Onchocerca volvulus		0.126144	0.00920146	0.0106294
Echinococcus granulosus	src region	0.126144	0.00920146	0.00920146
Onchocerca volvulus		0.186414	0.0202546	0.0689282
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.129355	0.00979033	0.00979033
Loa Loa (eye worm)	phosphatidylinositol 3	0.787759	0.130539	0.147095
Entamoeba histolytica	unconventional myosin IB	0.126144	0.00920146	0.00292539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.386535	0.0569559	0.0695241
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.129355	0.00979033	0.00979033
Schistosoma mansoni	tensin-related	0.129355	0.00979033	0.0097846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.714365	0.117078	0.157054
Loa Loa (eye worm)	hypothetical protein	0.386535	0.0569559	0.0641798
Trypanosoma cruzi	target of rapamycin kinase 3	0.713907	0.116995	0.166247
Trichomonas vaginalis	phosphatidylinositol kinase, putative	3.87147	0.696077	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.130215	0.00994806	0.00994233
Leishmania major	hypothetical protein, conserved	1.49535	0.260308	1
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.126144	0.00920146	0.00920146
Schistosoma mansoni	dreadlocks/dock	0.126144	0.00920146	0.00919572
Loa Loa (eye worm)	hypothetical protein	0.186414	0.0202546	0.0228236
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Loa Loa (eye worm)	phosphatidylinositol 3	0.245756	0.0311377	0.035087
Echinococcus multilocularis	tyrosine protein kinase HCK	0.48952	0.0758431	0.0758431
Schistosoma mansoni	cell polarity protein	0.126144	0.00920146	0.00919572
Schistosoma mansoni	formin binding protein and related proteins	0.126144	0.00920146	0.00919572
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Onchocerca volvulus	Putative cortactin	0.126144	0.00920146	0.0106294
Echinococcus multilocularis	expressed protein	0.126144	0.00920146	0.00920146
Schistosoma mansoni	tyrosine kinase	0.481307	0.0743367	0.0743314
Schistosoma mansoni	tensin	0.129355	0.00979033	0.0097846
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Echinococcus granulosus	tyrosine protein kinase Fyn	0.74502	0.1227	0.1227
Echinococcus granulosus	roundabout 2	0.135497	0.0109168	0.0109168
Echinococcus granulosus	tyrosine protein kinase HCK	0.48952	0.0758431	0.0758431
Brugia malayi	Tensin	0.129355	0.00979033	0.014065
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.548088	0.086584	0.122462
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.130757	0.0100475	0.00415352
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.386535	0.0569559	0.0818241
Loa Loa (eye worm)	p53BP2	0.126144	0.00920146	0.0103685
Echinococcus granulosus	tyrosine protein kinase shark	0.186414	0.0202546	0.0202546
Loa Loa (eye worm)	guanylate kinase	0.126144	0.00920146	0.0103685
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.130215	0.00994806	0.00994806
Echinococcus granulosus	endonuclease reverse transcriptase	0.115156	0.00718618	0.00718618
Onchocerca volvulus		0.186414	0.0202546	0.0689282
Echinococcus granulosus	tyrosine protein kinase Src64B	0.74502	0.1227	0.1227
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.859497	0.143695	0.338106
Brugia malayi	Tyrosine-protein kinase abl-1	1.31685	0.227572	0.326935
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.393002	0.0581419	0.249878
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	1.3197	0.228094	0.320671
Leishmania major	phosphatidylinositol kinase related protein, putative	0.245756	0.0311377	0.114419
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.500251	0.077811	0.077811
Echinococcus granulosus	signal transduction protein lnk realted	0.129355	0.00979033	0.00979033
Schistosoma mansoni	signal transduction protein lnk-related	0.129355	0.00979033	0.0097846
Onchocerca volvulus		0.129355	0.00979033	0.0137353
Loa Loa (eye worm)	hypothetical protein	1.6107	0.281462	0.317161
Schistosoma mansoni	tyrosine kinase	0.718561	0.117848	0.117843
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0976399	0.0039739	0.0039739
Echinococcus multilocularis	neuroglian	0.0929707	0.00311758	0.00311758
Echinococcus granulosus	NCK adaptor protein	0.255499	0.0329246	0.0329246
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.386535	0.0569559	0.0798038
Loa Loa (eye worm)	phosphatidylinositol kinase	0.245756	0.0311377	0.035087
Echinococcus granulosus	neuroglian	0.0929707	0.00311758	0.00311758
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.126144	0.00920146	0.00919572
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.245756	0.0311377	0.031132
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.129355	0.00979033	0.0097846
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Brugia malayi	RhoGAP domain containing protein	0.130215	0.00994806	0.0142916
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.386535	0.0569559	0.0569504
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.787759	0.130539	0.185747
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0843046	0.00152826	0.00152826
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.126144	0.00920146	0.0110477
Brugia malayi	protein-tyrosine kinase	0.618876	0.0995662	0.143039
Loa Loa (eye worm)	hypothetical protein	0.116553	0.00744244	0.00838639
Schistosoma mansoni	hypothetical protein	0.129355	0.00979033	0.0097846
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.705956	0.115536	0.13019
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	3.87147	0.696077	1
Echinococcus granulosus	tensin	0.129355	0.00979033	0.00979033
Brugia malayi	Variant SH3 domain containing protein	0.255499	0.0329246	0.0473002
Echinococcus granulosus	tyrosine protein kinase csk	0.0898902	0.00255264	0.00255264
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.129355	0.00979033	0.0110321
Onchocerca volvulus		0.126144	0.00920146	0.0106294
Loa Loa (eye worm)	TK/INSR protein kinase	0.481307	0.0743367	0.0837651
Echinococcus multilocularis	tensin	0.129355	0.00979033	0.00979033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.62194	0.100128	0.132377
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0843046	0.00152826	0.00152826
Schistosoma mansoni	hypothetical protein	0.129355	0.00979033	0.0097846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.621482	0.100044	0.132255
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.432399	0.0653671	0.281768
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.327022	0.0460416	0.0460416
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.245756	0.0311377	0.0311377
Loa Loa (eye worm)	TK/CSK protein kinase	0.0898902	0.00255264	0.0028764
Echinococcus granulosus	tyrosine protein kinase Srms	0.186414	0.0202546	0.0202546
Trypanosoma cruzi	hypothetical protein, conserved	0.126144	0.00920146	0.0110477
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.126144	0.00920146	0.0103685
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.548088	0.086584	0.32868
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	3.87147	0.696077	1
Brugia malayi	hypothetical protein	0.129355	0.00979033	0.014065
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.245756	0.0311377	0.221056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.787759	0.130539	0.176651
Entamoeba histolytica	hypothetical protein	0.126144	0.00920146	0.00292539
Leishmania major	phosphatidylinositol 3-kinase, putative	0.705956	0.115536	0.44056
Echinococcus granulosus	SHC transforming protein 3	0.129355	0.00979033	0.00979033
Echinococcus multilocularis	N chimaerin	0.130215	0.00994806	0.00994806
Echinococcus multilocularis	transfer RNA-Ala	0.126144	0.00920146	0.00920146
Loa Loa (eye worm)	hypothetical protein	2.26077	0.400682	0.451502
Schistosoma mansoni	run and tbc1 domain containing	0.126144	0.00920146	0.00919572
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.129355	0.00979033	0.0137353
Loa Loa (eye worm)	TK/EPH protein kinase	0.672983	0.109489	0.123376
Schistosoma mansoni	growth factor receptor-bound protein	0.255499	0.0329246	0.032919
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.705956	0.115536	1
Loa Loa (eye worm)	hypothetical protein	0.407309	0.0607658	0.068473
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.245756	0.0311377	0.130688
Brugia malayi	SH2 domain containing protein	0.129355	0.00979033	0.014065
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.126144	0.00920146	0.0103685
Loa Loa (eye worm)	hypothetical protein	0.246752	0.0313204	0.0352929
Echinococcus multilocularis	tyrosine kinase	0.186414	0.0202546	0.0202546
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.548088	0.086584	0.375414
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	2.31666	0.410932	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.548088	0.086584	0.122462
Loa Loa (eye worm)	hypothetical protein	0.115156	0.00718618	0.00809763
Entamoeba histolytica	protein kinase, putative	0.116558	0.00744336	0.000373321
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.705956	0.115536	0.15481
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.126144	0.00920146	0.00920146
Loa Loa (eye worm)	TK protein kinase	0.618876	0.0995662	0.112195
Schistosoma mansoni	growth factor receptor-bound protein	0.255499	0.0329246	0.032919
Echinococcus granulosus	c src tyrosine kinase	0.345389	0.0494101	0.0494101
Loa Loa (eye worm)	hypothetical protein	0.0930023	0.00312337	0.00351952
Loa Loa (eye worm)	hypothetical protein	0.245756	0.0311377	0.035087
Entamoeba histolytica	hypothetical protein	0.126144	0.00920146	0.00292539
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Leishmania major	hypothetical protein, unknown function	0.245756	0.0311377	0.114419
Loa Loa (eye worm)	hypothetical protein	0.129606	0.00983639	0.011084
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.705956	0.115536	0.164147
Echinococcus granulosus	intersectin 2	0.126144	0.00920146	0.00920146
Echinococcus multilocularis	c src tyrosine kinase	0.345389	0.0494101	0.0494101
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.245756	0.0311377	0.0426311
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	5.52867	1	1
Echinococcus multilocularis		0.432399	0.0653671	0.0653671
Schistosoma mansoni	SH2A	0.129355	0.00979033	0.0097846
Trichomonas vaginalis	phosphatidylinositol kinase, putative	1.3197	0.228094	0.318678
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.129355	0.00979033	0.014065
Schistosoma mansoni	vav2	0.130466	0.00999412	0.00998838
Entamoeba histolytica	hypothetical protein	0.126144	0.00920146	0.00292539
Entamoeba histolytica	hypothetical protein	3.25773	0.58352	0.836611
Loa Loa (eye worm)	hypothetical protein	0.0930023	0.00312337	0.00351952
Brugia malayi	Fes/CIP4 homology domain containing protein	0.126144	0.00920146	0.013219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.140779	0.0118854	0.00390748
Schistosoma mansoni	hypothetical protein	0.126145	0.00920154	0.0091958
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.548088	0.086584	0.086584
Brugia malayi	SH2 domain containing protein	0.129355	0.00979033	0.014065
Echinococcus granulosus	serine protein kinase ATM	0.386535	0.0569559	0.0569559
Loa Loa (eye worm)	thyroid receptor interactor	0.126144	0.00920146	0.0103685
Brugia malayi	Fibronectin type III domain containing protein	0.0930023	0.00312337	0.00448711
Echinococcus granulosus	tyrosine protein kinase ABL1	2.31846	0.411262	0.411262
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.129606	0.00983639	0.011084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.573586	0.0912602	0.119467
Brugia malayi	Variant SH3 domain containing protein	0.126144	0.00920146	0.013219
Onchocerca volvulus		0.186414	0.0202546	0.0689282
Echinococcus granulosus	tyrosine protein kinase Src42A	0.74502	0.1227	0.1227
Schistosoma mansoni	Dab2-interacting protein-like	0.126144	0.00920146	0.00919572
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	3.62571	0.651007	0.934575
Trichomonas vaginalis	PIKK family atypical protein kinase	0.695334	0.113588	0.151973
Loa Loa (eye worm)	phosphatidylinositol 3	0.548088	0.086584	0.0975658
Brugia malayi	Myosin tail family protein	0.126144	0.00920146	0.013219
Brugia malayi	hypothetical protein	0.186414	0.0202546	0.0290982
Onchocerca volvulus		0.129355	0.00979033	0.0137353
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.432399	0.0653671	0.0919141
Trichomonas vaginalis	conserved hypothetical protein	0.140779	0.0118854	0.00390748
Entamoeba histolytica	protein kinase rad3, putative	0.386535	0.0569559	0.0722461
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	2.9304	0.523489	0.748735
Plasmodium vivax	hypothetical protein, conserved	0.115156	0.00718618	0.0366636
Brugia malayi	tRNA modification GTPase TrmE family protein	0.129355	0.00979033	0.014065
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Brugia malayi	STAT protein, DNA binding domain containing protein	0.129355	0.00979033	0.014065
Brugia malayi	SRC-1	0.74502	0.1227	0.176274
Brugia malayi	SH2 domain containing protein	0.186414	0.0202546	0.0290982
Loa Loa (eye worm)	hypothetical protein	0.116553	0.00744244	0.00838639
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0843046	0.00152826	0.00172209
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	3.87147	0.696077	1
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.126144	0.00920146	0.00920146
Echinococcus granulosus	tyrosine kinase	0.618876	0.0995662	0.0995662
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.705956	0.115536	0.15481
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.705956	0.115536	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.161553	0.0156953	0.0156953
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.548088	0.086584	0.086584
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.245756	0.0311377	0.0319362
Entamoeba histolytica	SH2 domain containing protein	0.129355	0.00979033	0.0037802
Trichomonas vaginalis	PIKK family atypical protein kinase	0.533781	0.0839602	0.108839
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.787759	0.130539	0.498533
Schistosoma mansoni	nephrin	0.111915	0.00659191	0.00658616
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.77562	0.128312	0.128312
Echinococcus granulosus	insulin receptor	0.481307	0.0743367	0.0743367
Entamoeba histolytica	protein kinase, putative	0.48952	0.0758431	0.0996629
Brugia malayi	GCC2 and GCC3 family protein	0.115156	0.00718618	0.0103238
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.74502	0.1227	0.1227
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.245756	0.0311377	0.249615
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.129355	0.00979033	0.00979033
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.432399	0.0653671	0.0653671
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.126395	0.00924751	0.00924751
Trichomonas vaginalis	PIKK family atypical protein kinase	0.714365	0.117078	0.157054
Brugia malayi	SH2 domain containing protein	0.129355	0.00979033	0.014065
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.126395	0.00924751	0.00924751
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.245756	0.0311377	0.0311377
Trichomonas vaginalis	PIKK family atypical protein kinase	0.62194	0.100128	0.132377
Echinococcus multilocularis	tyrosine protein kinase csk	0.0898902	0.00255264	0.00255264
Loa Loa (eye worm)	protein-tyrosine kinase	0.126144	0.00920146	0.0103685
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Echinococcus multilocularis	SHC transforming protein 3	0.129355	0.00979033	0.00979033
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.319607	0.0446817	0.0516546
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.245756	0.0311377	0.0311377
Leishmania major	phosphatidylinositol kinase, putative	0.245756	0.0311377	0.114419
Entamoeba histolytica	hypothetical protein	0.126395	0.00924751	0.00299224
Trichomonas vaginalis	PIKK family atypical protein kinase	0.245756	0.0311377	0.0319362
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Leishmania major	phosphatidylinositol 3-kinase, putative	0.548088	0.086584	0.32868
Brugia malayi	cytokine inducible SH2-containing protein 5	0.129355	0.00979033	0.014065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.386535	0.0569559	0.0695241
Trichomonas vaginalis	PIKK family atypical protein kinase	0.548088	0.086584	0.112659
Brugia malayi	P38 map kinase family protein 2	0.0843046	0.00152826	0.00219553
Brugia malayi	Guanylate kinase family protein	0.126144	0.00920146	0.013219
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.787759	0.130539	0.179059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.626206	0.10091	0.133516
Echinococcus multilocularis	endonuclease reverse transcriptase	0.115156	0.00718618	0.00718618
Onchocerca volvulus		0.129355	0.00979033	0.0137353
Trichomonas vaginalis	PIKK family atypical protein kinase	0.621482	0.100044	0.132255
Schistosoma mansoni	hypothetical protein	0.245756	0.0311377	0.031132
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.245756	0.0311377	0.0311377
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	5.52867	1	1
Brugia malayi	SH2 domain containing protein	0.129355	0.00979033	0.014065
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.126144	0.00920146	0.00920146
Schistosoma mansoni	tensin	0.129355	0.00979033	0.0097846
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.129355	0.00979033	0.00979033
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.705956	0.115536	0.115536
Entamoeba histolytica	protein kinase, putative	0.130757	0.0100475	0.00415352
Onchocerca volvulus		0.129355	0.00979033	0.0137353
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.115156	0.00718618	0.0366636
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	1.3197	0.228094	0.320671
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Onchocerca volvulus		0.245756	0.0311377	0.12633
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.129355	0.00979033	0.0137353
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.787759	0.130539	0.187535
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.186414	0.0202546	0.0202546
Schistosoma mansoni	tyrosine kinase	0.74502	0.1227	0.122695
Loa Loa (eye worm)	phosphatidylinositol 3	0.432399	0.0653671	0.0736579
Plasmodium vivax	hypothetical protein	0.245756	0.0311377	0.249615
Toxoplasma gondii	phosphatidylinositol 4-kinase	0.186643	0.0202967	0.0919519
Echinococcus granulosus	mitogen activated protein kinase 14	0.0843046	0.00152826	0.00152826
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0843046	0.00152826	0.00152826
Echinococcus granulosus	SH2 domain containing protein 7	0.129355	0.00979033	0.00979033
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Schistosoma mansoni	serine/threonine protein kinase	0.183203	0.0196657	0.0196601
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.74502	0.1227	0.1227
Trichomonas vaginalis	conserved hypothetical protein	0.161553	0.0156953	0.00945421
Loa Loa (eye worm)	hypothetical protein	0.872253	0.146034	0.164557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.695334	0.113588	0.151973
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	3.87147	0.696077	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.500251	0.077811	0.077811
Trichomonas vaginalis	PIKK family atypical protein kinase	0.621482	0.100044	0.132255
Echinococcus multilocularis	SH2 motif	0.129355	0.00979033	0.00979033
Schistosoma mansoni	hypothetical protein	0.126144	0.00920146	0.00919572
Echinococcus granulosus	suppressor of cytokine signaling 6	0.129355	0.00979033	0.00979033
Entamoeba histolytica	BAR/SH3 domain containing protein	0.126144	0.00920146	0.00292539
Schistosoma mansoni	tyrosine kinase	0.718561	0.117848	0.117843
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	1.3197	0.228094	0.318678
Leishmania major	phosphatidylinositol 4-kinase, putative	0.432399	0.0653671	0.246692
Echinococcus multilocularis	tyrosine protein kinase Srms	0.618876	0.0995662	0.0995662
Loa Loa (eye worm)	hypothetical protein	0.129355	0.00979033	0.0110321
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.74502	0.1227	0.1227
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.713907	0.116995	0.509638
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.245756	0.0311377	0.0426311
Trypanosoma cruzi	hypothetical protein, conserved	0.126144	0.00920146	0.0110477
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.129355	0.00979033	0.00979033
Mycobacterium leprae	conserved hypothetical protein	0.245756	0.0311377	0.5
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.480703	0.074226	0.320869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.386535	0.0569559	0.0695241
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.705956	0.115536	0.503201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.714365	0.117078	0.157054
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	1.3197	0.228094	0.318678
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	1.64703	0.288124	0.407812
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.386535	0.0569559	0.0722461
Echinococcus multilocularis	intersectin 2	0.126144	0.00920146	0.00920146
Brugia malayi	Protein kinase domain containing protein	0.186414	0.0202546	0.0290982
Plasmodium vivax	cysteine repeat modular protein 3, putative	0.115156	0.00718618	0.0366636
Schistosoma mansoni	apoptosis stimulating of P53	0.126144	0.00920146	0.00919572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.533781	0.0839602	0.108839
Echinococcus granulosus	fch and double sh3 domains protein 2	0.126144	0.00920146	0.00920146
Echinococcus multilocularis	signal transduction protein lnk realted	0.129355	0.00979033	0.00979033
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.74502	0.1227	0.1227
Brugia malayi	GCC2 and GCC3 family protein	0.115156	0.00718618	0.0103238
Echinococcus granulosus	N chimaerin	0.130215	0.00994806	0.00994806
Entamoeba histolytica	hypothetical protein	0.245756	0.0311377	0.0347682
Echinococcus granulosus	mitogen activated protein kinase 11	0.0843046	0.00152826	0.00152826
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.118349	0.00777177	0.00777177
Brugia malayi	Tyrosine-protein kinase abl-1	1.12775	0.192892	0.277113
Brugia malayi	Sex muscle abnormal protein 5	0.255499	0.0329246	0.0473002
Echinococcus multilocularis	epidermal growth factor receptor	0.77562	0.128312	0.128312
Schistosoma mansoni	adapter molecule crk	0.255499	0.0329246	0.032919
Brugia malayi	Protein kinase domain containing protein	0.186414	0.0202546	0.0290982
Echinococcus multilocularis	NCK adaptor protein	0.255499	0.0329246	0.0329246
Brugia malayi	Protein kinase domain containing protein	0.481307	0.0743367	0.106794
Echinococcus multilocularis	endophilin A3	0.126144	0.00920146	0.00920146
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.432399	0.0653671	0.0939079
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.129355	0.00979033	0.00979033
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.386535	0.0569559	0.244643
Echinococcus multilocularis	tensin	0.129355	0.00979033	0.00979033
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.126144	0.00920146	0.0106294
Giardia lamblia	GTOR	0.787759	0.130539	0.30552
Loa Loa (eye worm)	hypothetical protein	0.0976399	0.0039739	0.00447792
Giardia lamblia	Phosphatidylinositol 4-kinase	0.432399	0.0653671	0.144103
Plasmodium vivax	hypothetical protein, conserved	0.245756	0.0311377	0.249615
Brugia malayi	Furin-like cysteine rich region family protein	1.40103	0.243011	0.349115
Entamoeba histolytica	hypothetical protein, conserved	0.126144	0.00920146	0.00292539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.548088	0.086584	0.112659
Loa Loa (eye worm)	SH2 domain-containing protein	0.129355	0.00979033	0.0110321
Echinococcus granulosus	ephrin type A receptor 4 A	0.655611	0.106303	0.106303
Trichomonas vaginalis	PIKK family atypical protein kinase	0.621482	0.100044	0.132255
Schistosoma mansoni	dynamin-associated protein	0.126144	0.00920146	0.00919572
Trypanosoma cruzi	hypothetical protein, conserved	0.126144	0.00920146	0.0110477
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	2.26077	0.400682	0.400682
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.618876	0.0995662	0.0995662
Echinococcus granulosus	tyrosine protein kinase csk	0.0898902	0.00255264	0.00255264
Onchocerca volvulus		0.127547	0.00945864	0.0119858
Schistosoma mansoni	suppressor of cytokine signaling	0.129355	0.00979033	0.0097846
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.407309	0.0607658	0.375787
Loa Loa (eye worm)	TK/EGFR protein kinase	1.40103	0.243011	0.273833
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.432399	0.0653671	0.553948
Schistosoma mansoni	tyrosine kinase	1.40103	0.243011	0.243006
Echinococcus granulosus	epidermal growth factor receptor kinase	0.126144	0.00920146	0.00920146
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.74502	0.1227	0.1227
Trichomonas vaginalis	PIKK family atypical protein kinase	0.787759	0.130539	0.176651
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.245756	0.0311377	0.031132
Entamoeba histolytica	hypothetical protein	0.126144	0.00920146	0.00292539
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.787759	0.130539	0.569417
Trichomonas vaginalis	PIKK family atypical protein kinase	0.714365	0.117078	0.157054
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.126144	0.00920146	0.00919572
Schistosoma mansoni	ephrin receptor	0.540455	0.0851843	0.085179
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.129355	0.00979033	0.0110321
Plasmodium vivax	cysteine repeat modular protein 2, putative	0.115156	0.00718618	0.0366636
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	3.87147	0.696077	1
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.126144	0.00920146	0.00919572
Trichomonas vaginalis	PIKK family atypical protein kinase	0.548088	0.086584	0.112659
Toxoplasma gondii	1-phosphatidylinositol 4-kinase	0.186643	0.0202967	0.0919519
Brugia malayi	SH2 domain containing protein	0.129355	0.00979033	0.014065
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	2.26077	0.400682	0.400682
Echinococcus granulosus	twitchin	0.094373	0.00337476	0.00337476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.533781	0.0839602	0.108839
Schistosoma mansoni	tyrosine kinase	0.77562	0.128312	0.128307
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.705956	0.115536	0.44056
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.312558	0.0433889	0.0433834
Brugia malayi	GCC2 and GCC3 family protein	0.115156	0.00718618	0.0103238
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.705956	0.115536	0.115536
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.386535	0.0569559	0.0569559
Loa Loa (eye worm)	SRC-1	0.74502	0.1227	0.138263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.695334	0.113588	0.151973
Loa Loa (eye worm)	TK/FER protein kinase	0.186414	0.0202546	0.0228236
Onchocerca volvulus		0.186414	0.0202546	0.0689282
Entamoeba histolytica	protein kinase, putative	0.126144	0.00920146	0.00292539
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.561817	0.0891019	0.0891019
Onchocerca volvulus		0.126144	0.00920146	0.0106294
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.126144	0.00920146	0.00920146
Entamoeba histolytica	hypothetical protein	0.126144	0.00920146	0.00292539
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.129355	0.00979033	0.0097846
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.705956	0.115536	0.157282
Schistosoma mansoni	tensin-related	0.129355	0.00979033	0.0097846
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.129355	0.00979033	0.00979033
Echinococcus multilocularis	tyrosine protein kinase csk	0.0898902	0.00255264	0.00255264
Schistosoma mansoni	tyrosine kinase	0.186414	0.0202546	0.0202489
Schistosoma mansoni	tyrosine kinase	0.0995536	0.00432485	0.00431909
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.129355	0.00979033	0.00979033
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.130215	0.00994806	0.0112098
Echinococcus granulosus	tyrosine protein kinase Fyn	0.74502	0.1227	0.1227
Brugia malayi	SH2 domain containing protein	0.219245	0.0262758	0.0377484
Entamoeba histolytica	hypothetical protein, conserved	0.126144	0.00920146	0.00292539
Loa Loa (eye worm)	hypothetical protein	0.115156	0.00718618	0.00809763
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.255499	0.0329246	0.032919
Brugia malayi	ephrin receptor 1 precursor	0.284866	0.0383104	0.0550375
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.892599	0.149766	1
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.126144	0.00920146	0.00920146
Schistosoma mansoni	hypothetical protein	0.115156	0.00718618	0.00718044
Entamoeba histolytica	hypothetical protein	0.245756	0.0311377	0.0347682
Loa Loa (eye worm)	hypothetical protein	0.0930023	0.00312337	0.00351952
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	5.52867	1	1
Loa Loa (eye worm)	hypothetical protein	0.161553	0.0156953	0.017686
Loa Loa (eye worm)	SH2 domain-containing protein	0.129355	0.00979033	0.0110321
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.129355	0.00979033	0.00979033
Brugia malayi	Spectrin alpha chain	0.126145	0.00920154	0.0132191
Onchocerca volvulus		0.126144	0.00920146	0.0106294
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.548088	0.086584	0.375414
Echinococcus granulosus	epidermal growth factor receptor	1.40103	0.243011	0.243011
Brugia malayi	SH3 domain containing protein	0.126144	0.00920146	0.013219
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.245756	0.0311377	0.0447331
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.787759	0.130539	0.498533
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.618876	0.0995662	0.0995662
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.126144	0.00920146	0.00920146
Echinococcus granulosus	epidermal growth factor receptor	0.77562	0.128312	0.128312
Toxoplasma gondii	target of rapamycin (TOR), putative	0.695334	0.113588	0.746265
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.705956	0.115536	0.164147
Echinococcus granulosus	tyrosine protein kinase Src42A	0.561817	0.0891019	0.0891019
Schistosoma mansoni	hypothetical protein	0.161553	0.0156953	0.0156896
Echinococcus granulosus	tyrosine protein kinase Lyn	0.746422	0.122958	0.122958
Onchocerca volvulus		0.483397	0.07472	0.356201
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.245756	0.0311377	0.0347682
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	1.3197	0.228094	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.245756	0.0311377	0.0447331
Echinococcus granulosus	hypothetical protein	0.129355	0.00979033	0.00979033
Echinococcus granulosus	tyrosine protein kinase csk	0.0898902	0.00255264	0.00255264
Loa Loa (eye worm)	TK/KIN16 protein kinase	1.22768	0.211219	0.238009
Echinococcus granulosus	growth factor receptor bound protein 2	0.255499	0.0329246	0.0329246
Loa Loa (eye worm)	hypothetical protein	0.483397	0.07472	0.084197
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.245756	0.0311377	0.167987
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.126144	0.00920146	0.00920146
Trichomonas vaginalis	PIKK family atypical protein kinase	0.640513	0.103534	0.137336
Loa Loa (eye worm)	TK/ABL protein kinase	2.31846	0.411262	0.463424
Echinococcus granulosus	nostrin	0.126144	0.00920146	0.00920146
Loa Loa (eye worm)	hypothetical protein	0.140779	0.0118854	0.0133929
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.74502	0.1227	0.1227
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.74502	0.1227	0.1227
Echinococcus multilocularis	insulin receptor	0.481307	0.0743367	0.0743367
Loa Loa (eye worm)	hypothetical protein	0.126144	0.00920146	0.0103685
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.245756	0.0311377	0.0319362
Toxoplasma gondii	FATC domain-containing protein	0.386535	0.0569559	0.349066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.695334	0.113588	0.151973
Loa Loa (eye worm)	hypothetical protein	0.115156	0.00718618	0.00809763
Brugia malayi	Variant SH3 domain containing protein	0.126144	0.00920146	0.013219
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	2.26077	0.400682	0.575629
Brugia malayi	GCC2 and GCC3 family protein	0.115156	0.00718618	0.0103238
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.787759	0.130539	0.569417
Brugia malayi	Variant SH3 domain containing protein	0.126144	0.00920146	0.013219
Echinococcus multilocularis	ephrin type A receptor 4 A	0.655611	0.106303	0.106303
Loa Loa (eye worm)	phosphatidylinositol 3	1.07394	0.183023	0.206237
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.705956	0.115536	0.115531
Echinococcus granulosus	endophilin A3	0.126144	0.00920146	0.00920146
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0843046	0.00152826	0.00152826
Echinococcus multilocularis	tyrosine protein kinase Abl	1.12775	0.192892	0.192892
Mycobacterium tuberculosis	Conserved hypothetical protein	0.245756	0.0311377	0.5
Schistosoma mansoni	tensin	0.129355	0.00979033	0.0097846
Entamoeba histolytica	hypothetical protein	0.126144	0.00920146	0.00292539
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0930023	0.00312337	0.00448711
Onchocerca volvulus		1.07299	0.182848	0.926513
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.161553	0.0156953	0.0156953
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.432399	0.0653671	0.0653617
Echinococcus granulosus	SH2 domain containing adapter protein F	0.129355	0.00979033	0.00979033
Echinococcus multilocularis		0.129355	0.00979033	0.00979033
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.705956	0.115536	0.115531
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.705956	0.115536	0.157282

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 500 nM	Inhibition of scarpie prion formation in mouse ScN2a cell line	ChEMBL.	16913719
Activity (functional)	= 500 nM	Inhibition of scarpie prion formation in mouse ScN2a cell line	ChEMBL.	16913719
Activity (ADMET)	= 2500 nM	Toxicity against ScN2a cell line	ChEMBL.	16913719
Activity (ADMET)	= 2500 nM	Toxicity against ScN2a cell line	ChEMBL.	16913719
CC50 (ADMET)	= 1000 nM	Toxicity against MRC5 cell line	ChEMBL.	16913719
CC50 (ADMET)	= 1000 nM	Toxicity against MRC5 cell line	ChEMBL.	16913719
EC50 (functional)	= 250 nM	Inhibition of scarpie prion formation in mouse ScN2a cell line relative to control	ChEMBL.	16913719
EC50 (functional)	= 250 nM	Inhibition of scarpie prion formation in mouse ScN2a cell line relative to control	ChEMBL.	16913719
IC50 (functional)	= 16.7 nM	Antimalarial activity was determined against the Chloroquine resistant strain FcB1 of Plasmodium falciparum	ChEMBL.	12182868
IC50 (functional)	= 16.7 nM	Antimalaraial activity against CQ-resistant Plasmodium falciparum FcB1	ChEMBL.	16913719
IC50 (functional)	= 16.7 nM	Antimalarial activity was determined against the Chloroquine resistant strain FcB1 of Plasmodium falciparum	ChEMBL.	12182868
IC50 (functional)	= 16.7 nM	Antimalaraial activity against CQ-resistant Plasmodium falciparum FcB1	ChEMBL.	16913719
IC50 (functional)	= 1 uM	Cytotoxicity tests were performed on a human diploid embryonic lung cell line (MRC5) using the colorimetric MTT assay	ChEMBL.	12182868
IC50 (functional)	= 1 uM	Cytotoxicity tests were performed on a human diploid embryonic lung cell line (MRC5) using the colorimetric MTT assay	ChEMBL.	12182868
Inhibition (functional)	> 80 %	Inhibition of Plasmodium falciparum growth at 10 nM	ChEMBL.	12182868
Inhibition (functional)	> 80 %	Inhibition of Plasmodium falciparum growth at 10 nM	ChEMBL.	12182868
Selectivity index (functional)	= 4	Selectivity index, toxicity against MRC5 cell line/EC50 for scarpie prion formation in mouse ScN2a cell line	ChEMBL.	16913719
Selectivity index (functional)	= 10	Selectivity index, toxicity against ScN2a cell line/EC50 for scarpie prion formation in mouse ScN2a cell line	ChEMBL.	16913719

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference
Plasmodium falciparum	ChEMBL23	12182868
Mus musculus	ChEMBL23	16913719
Homo sapiens	ChEMBL23	12182868

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL89645

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 145270