Detailed information for compound 14559

Basic information

Technical information
  • TDR Targets ID: 14559
  • Name: 4-chloro-N-methyl-6-(4-methylpiperazin-1-yl)- 5-phenylsulfanylpyrimidin-2-amine
  • MW: 349.882 | Formula: C16H20ClN5S
  • H donors: 1 H acceptors: 2 LogP: 3.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nc(N2CCN(CC2)C)c(c(n1)Cl)Sc1ccccc1
  • InChi: 1S/C16H20ClN5S/c1-18-16-19-14(17)13(23-12-6-4-3-5-7-12)15(20-16)22-10-8-21(2)9-11-22/h3-7H,8-11H2,1-2H3,(H,18,19,20)
  • InChiKey: FXWLTAOMDAMINN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-methyl-6-(4-methylpiperazin-1-yl)-5-phenylsulfanyl-pyrimidin-2-amine
  • 4-chloro-N-methyl-6-(4-methyl-1-piperazinyl)-5-(phenylthio)-2-pyrimidinamine
  • [4-chloro-6-(4-methylpiperazino)-5-(phenylthio)pyrimidin-2-yl]-methyl-amine
  • [4-chloro-6-(4-methylpiperazin-1-yl)-5-(phenylthio)pyrimidin-2-yl]-methyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Homo sapiens dopamine receptor D4 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 7TM GPCR rhodopsin 0.0137 0.0287 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Brugia malayi hypothetical protein 0.0012 0.0009 0.001
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0043 0.0557
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0137 0.0287 0.0606
Brugia malayi Cation transporter family protein 0.0027 0.0041 0.0045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0006
Loa Loa (eye worm) TYRA-2 protein 0.0137 0.0287 0.0606
Brugia malayi Cation transporter family protein 0.0027 0.0041 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0006
Toxoplasma gondii hypothetical protein 0.0362 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Onchocerca volvulus 0.0137 0.0287 0.0604
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0009 0.0018
Loa Loa (eye worm) melatonin receptor type 1A 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Loa Loa (eye worm) histone methyltransferase 0.001 0.0002 0.0005
Echinococcus multilocularis nAChR subunit 0.0027 0.0041 0.0042
Echinococcus multilocularis cpg binding protein 0.0033 0.0054 0.0056
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0001 0.0001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0137 0.0287 0.0296
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358 0.078 1
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0021 0.0027 0.0342
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0556 0.1222 0.2579
Schistosoma mansoni biogenic amine receptor 0.0137 0.0287 0.0606
Echinococcus granulosus biogenic amine 5HT receptor 0.0534 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0001 0.0001
Brugia malayi nuclear hormone receptor 0.0011 0.0005 0.0006
Onchocerca volvulus 0.0137 0.0287 0.0604
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0021 0.0027 0.0345
Schistosoma mansoni nAChR subunit 0.0027 0.0041 0.0087
Brugia malayi Dopamine receptor protein 2 0.0137 0.0287 0.0317
Echinococcus multilocularis orexin receptor type 2 0.0137 0.0287 0.0296
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.2131 0.4738 1
Brugia malayi Flap endonuclease-1 0.0028 0.0043 0.0048
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0006
Schistosoma mansoni nAChR subunit 0.0027 0.0041 0.0087
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0019
Onchocerca volvulus 0.0137 0.0287 0.0604
Loa Loa (eye worm) neuropeptide F receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Plasmodium falciparum copper-transporting ATPase 0.0009 0.0001 0.0014
Brugia malayi Melatonin receptor type 1A 0.0137 0.0287 0.0317
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0001 0.0014
Entamoeba histolytica hypothetical protein 0.0107 0.0219 0.2677
Onchocerca volvulus 0.0011 0.0005 0.0009
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0021 0.0027 0.0054
Brugia malayi sulfakinin receptor protein 0.0137 0.0287 0.0317
Onchocerca volvulus 0.0012 0.0009 0.0016
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0137 0.0287 0.0317
Schistosoma mansoni nAChR subunit 0.0027 0.0041 0.0087
Onchocerca volvulus 0.0027 0.0041 0.0084
Echinococcus multilocularis serotonin receptor 0.0556 0.1222 0.126
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0362 0.0788 0.1664
Loa Loa (eye worm) hypothetical protein 0.0358 0.078 0.1646
Onchocerca volvulus 0.0137 0.0287 0.0604
Echinococcus granulosus g protein coupled receptor 0.0137 0.0287 0.0287
Loa Loa (eye worm) G-protein coupled receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0014
Echinococcus granulosus neuropeptide receptor 0.0137 0.0287 0.0287
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0362 0.0788 0.0788
Giardia lamblia Fructose-bisphosphate aldolase 0.032 0.0695 0.8502
Brugia malayi G protein-coupled receptor 0.0137 0.0287 0.0317
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0012 0.0009 0.001
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0001 0.0002
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0137 0.0287 0.0317
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0095 0.0193 0.0407
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0043 0.0532
Brugia malayi neuropeptide F receptor 0.0137 0.0287 0.0317
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0021 0.0027 0.0057
Echinococcus multilocularis neuropeptide receptor 0.0137 0.0287 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.0287 0.0287
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0137 0.0287 0.0606
Echinococcus granulosus neuropeptide Y receptor 0.0137 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0027 0.0041 0.0041
Mycobacterium ulcerans hypothetical protein 0.0171 0.0363 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0137 0.0287 0.0317
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Onchocerca volvulus Neuropeptide F receptor homolog 0.0137 0.0287 0.0604
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0137 0.0287 0.0606
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0001 0.0001
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0027 0.0041 0.0041
Echinococcus multilocularis serotonin receptor 0.0556 0.1222 0.126
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0006
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0362 0.0788 0.0813
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0027 0.0041 0.0045
Echinococcus granulosus g-protein coupled receptor 0.0137 0.0287 0.0287
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0001 0.0014
Toxoplasma gondii hypothetical protein 0.0052 0.0098 0.123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.0287 0.0296
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0001 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0137 0.0287 0.0296
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0027 0.0041 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0006
Onchocerca volvulus 0.0027 0.0041 0.0084
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0137 0.0287 0.0287
Schistosoma mansoni nAChR subunit 0.0027 0.0041 0.0087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0041 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.0006
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0021 0.0027 0.0372
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Echinococcus granulosus orexin receptor type 2 0.0137 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni biogenic amine receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.041 0.0896 0.1892
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Echinococcus granulosus neuropeptide FF receptor 2 0.0137 0.0287 0.0287
Echinococcus granulosus 7tm_1 domain containing protein 0.0137 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0041 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0362 0.0788 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0001 0.0001
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0021 0.0027 0.0345
Brugia malayi steroid hormone receptor 0.0011 0.0005 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.0287 0.0296
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0137 0.0287 0.0604
Schistosoma mansoni amine GPCR 0.0137 0.0287 0.0606
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0011 0.0006 0.0076
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0021 0.0027 0.0345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0005 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Echinococcus multilocularis nAChR subunit 0.0015 0.0013 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0003
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0011 0.0006 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0057
Schistosoma mansoni amine GPCR 0.0137 0.0287 0.0606
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0362 0.0788 0.1664
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0041 0.0045
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.0027 0.0057
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0101 0.0111
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0137 0.0287 0.0606
Schistosoma mansoni sodium/chloride dependent transporter 0.0362 0.0788 0.1664
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0362 0.0788 0.1664
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0006
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0362 0.0788 0.0788
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0137 0.0287 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.0287 0.0287
Loa Loa (eye worm) solute carrier family 6 member 4 0.2131 0.4738 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0362 0.0788 0.0813
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0001 0.0002
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0137 0.0287 0.0287
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0012 0.0009 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.0137 0.0287 0.0287
Trypanosoma brucei cation-transporting ATPase, putative 0.0009 0.0001 0.0014
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0001 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0362 0.0788 0.1664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0012
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0027 0.0041 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0362 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0101 0.0213
Echinococcus multilocularis neuropeptide receptor 0.0137 0.0287 0.0296
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0137 0.0287 0.0317
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0041 0.0045
Brugia malayi DNA polymerase alpha catalytic subunit 0.0021 0.0027 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0005 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.0287 0.0287
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0021 0.0027 0.0328
Echinococcus granulosus fmrfamide receptor 0.0137 0.0287 0.0287
Loa Loa (eye worm) norepinephrine transporter 0.2131 0.4738 1
Schistosoma mansoni hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0001 0.0001
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0001 0.0001
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0027 0.0041 0.0042
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0005 0.0012
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0137 0.0287 0.0604
Entamoeba histolytica hypothetical protein 0.0015 0.0013 0.0162
Onchocerca volvulus 0.0137 0.0287 0.0604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0001 0.0002
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0021 0.0027 0.003
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0009 0.0001 0.0014
Plasmodium vivax calcium-transporting ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0005 0.0012
Plasmodium vivax P-type ATPase4, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0021 0.0027 0.0345
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Onchocerca volvulus 0.0137 0.0287 0.0604
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Loa Loa (eye worm) hypothetical protein 0.0362 0.0788 0.1664
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0006
Leishmania major P-type H -ATPase, putative 0.0009 0.0001 0.0014
Onchocerca volvulus 0.0027 0.0041 0.0084
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0137 0.0287 0.0604
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0019
Echinococcus granulosus neuropeptide receptor A26 0.0137 0.0287 0.0287
Brugia malayi G protein-coupled receptor F59B2.13 0.0137 0.0287 0.0317
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0137 0.0287 0.0317
Schistosoma mansoni nAChR subunit 0.0027 0.0041 0.0087
Onchocerca volvulus 0.0362 0.0788 0.1662
Echinococcus granulosus sodium and chloride dependent glycine 0.0362 0.0788 0.0788
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0137 0.0287 0.0296
Schistosoma mansoni alpha-1 adrenergic receptor 0.0137 0.0287 0.0606
Plasmodium vivax cation transporting ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0556 0.1222 0.2579
Echinococcus granulosus dro:myosuppressin receptor 0.0137 0.0287 0.0287
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0027 0.0041 0.0041
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0015 0.0013 0.0028
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.004
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus granulosus nAChR subunit 0.0027 0.0041 0.0041
Brugia malayi RE15519p 0.0137 0.0287 0.0317
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0001 0.0001
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0001 0.0014
Brugia malayi putative neuropeptide receptor NPR1 0.0137 0.0287 0.0317
Schistosoma mansoni hypothetical protein 0.0441 0.0965 0.2036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0137 0.0287 0.0287
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0001 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0013 0.0028
Schistosoma mansoni biogenic amine (5HT) receptor 0.0556 0.1222 0.2579
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0012 0.0009 0.001
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0001 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0013 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0005 0.0009
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0001 0.0001
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0001 0.0001
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0362 0.0788 0.1664
Schistosoma mansoni neurotransmitter gated ion channel 0.0015 0.0013 0.0028
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0021 0.0027 0.0345
Onchocerca volvulus 0.0012 0.0009 0.0016
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0012 0.0009 0.0009
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0137 0.0287 0.0606
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0001 0.0014
Onchocerca volvulus 0.0137 0.0287 0.0604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0137 0.0287 0.0606
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0009 0.0001 0.0016
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0001 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.0287 0.0287
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0041 0.0045
Brugia malayi CXXC zinc finger family protein 0.0031 0.005 0.0055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0006
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0001 0.0014
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0005 0.0012
Echinococcus multilocularis G-protein coupled receptor, putative 0.0137 0.0287 0.0296
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Onchocerca volvulus 0.0015 0.0013 0.0026
Echinococcus granulosus biogenic amine 5HT receptor 0.0556 0.1222 0.1222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0107 0.0219 0.2677
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0009 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0012
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0018
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0021 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Onchocerca volvulus 0.0027 0.0041 0.0084
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.0965 0.0995
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) serotonin transporter b 0.2131 0.4738 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0005 0.0006
Schistosoma mansoni nAChR subunit 0.0027 0.0041 0.0087
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0137 0.0287 0.0296
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0027 0.0041 0.0041
Schistosoma mansoni sodium-dependent amino acid transporter 0.0362 0.0788 0.1664
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0001 0.0014
Brugia malayi hypothetical protein 0.0012 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis neuropeptide Y receptor 0.0137 0.0287 0.0296
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0137 0.0287 0.0606
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0021 0.0027 0.0027
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0009 0.0001 0.0014
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.1667 0.3518
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0043 0.0551
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.0287 0.0287
Brugia malayi Serotonin receptor 0.4064 0.9054 1
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0009 0.0001 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Brugia malayi hypothetical protein 0.0012 0.0009 0.001
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0009 0.0001 0.0017
Schistosoma mansoni neuropeptide f receptor 76f 0.0137 0.0287 0.0606
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0021 0.0027 0.0316
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0137 0.0287 0.0296
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0041 0.0087
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0021 0.0027 0.0345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0027 0.0041 0.0087
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0137 0.0287 0.0296
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0027 0.0041 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0358 0.078 0.0862
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.001
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.033 1
Loa Loa (eye worm) hypothetical protein 0.0362 0.0788 0.1664
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.0287 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.0695 0.8504
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0325 0.4161
Echinococcus granulosus microtubule associated protein 2 0.0755 0.1667 0.1667
Schistosoma mansoni ATPase 0.0009 0.0001 0.0002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0005 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0137 0.0287 0.0296
Schistosoma mansoni neuropeptide F-like receptor 0.0137 0.0287 0.0606
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0137 0.0287 0.0296
Loa Loa (eye worm) calcium ATPase 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0362 0.0788 0.0871
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0362 0.0788 1
Schistosoma mansoni hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi putative neuropeptide receptor 0.0137 0.0287 0.0317
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0027 0.0041 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0001 0.0014
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0005 0.0006
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0043 0.0557
Brugia malayi larval opioid receptor 0.0137 0.0287 0.0317
Loa Loa (eye worm) hypothetical protein 0.0362 0.0788 0.1664
Plasmodium falciparum flap endonuclease 1 0.0028 0.0043 0.0551
Echinococcus multilocularis sex peptide receptor 0.0137 0.0287 0.0296
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0043 0.061
Schistosoma mansoni biogenic amine (5HT) receptor 0.0534 0.1173 0.2476
Echinococcus multilocularis g-protein coupled receptor 0.0137 0.0287 0.0296
Schistosoma mansoni adenoreceptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0027 0.0041 0.0087
Toxoplasma gondii DNA polymerase 0.0021 0.0027 0.0328
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0001 0.0014
Echinococcus multilocularis g protein coupled receptor 0.0137 0.0287 0.0296
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0001 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0105 0.135
Loa Loa (eye worm) neuropeptide F receptor 0.0137 0.0287 0.0606
Plasmodium falciparum amino acid transporter, putative 0.0362 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus granulosus neuropeptide receptor 0.0137 0.0287 0.0287
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.004
Schistosoma mansoni neuropeptide receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Loa Loa (eye worm) ACC-1 protein 0.0027 0.0041 0.0087
Schistosoma mansoni cpg binding protein 0.0033 0.0054 0.0114
Onchocerca volvulus Putative nachr subunit 0.0027 0.0041 0.0084
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0027 0.0041 0.0045
Toxoplasma gondii DNA polymerase family B protein 0.0009 0.0001 0.0002
Brugia malayi Serotonin receptor 0.0137 0.0287 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.0287 0.0287
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0362 0.0788 0.0871
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0009 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0362 0.0788 0.1664
Echinococcus granulosus GPCR family 2 0.0017 0.0019 0.0019
Echinococcus granulosus serotonin receptor 0.0137 0.0287 0.0287
Loa Loa (eye worm) ACC-1 protein 0.0027 0.0041 0.0087
Schistosoma mansoni ATPase 0.0009 0.0001 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0137 0.0287 0.0606
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0027 0.0041 0.0087
Loa Loa (eye worm) hypothetical protein 0.2131 0.4738 1
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.0137 0.0287 0.0606
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0362 0.0788 0.1664
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0005 0.0012
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0041 0.0042
Brugia malayi G-protein coupled receptor 0.0137 0.0287 0.0317
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0325 0.0707 0.9067
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0043 0.0045
Echinococcus multilocularis conserved hypothetical protein 0.4351 0.9694 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis glycine receptor subunit beta 0.0027 0.0041 0.0042
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0362 0.0788 0.1664
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0001 0.0001
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0001 0.0014
Onchocerca volvulus 0.0362 0.0788 0.1662
Echinococcus granulosus glycine receptor subunit beta 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.2131 0.4738 1
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0137 0.0287 0.0287
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Brugia malayi ecdysteroid receptor 0.0011 0.0005 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.0137 0.0287 0.0296
Onchocerca volvulus 0.0027 0.0041 0.0084
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Loa Loa (eye worm) hypothetical protein 0.0362 0.0788 0.1664
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0001 0.0002
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) LGC-31 protein 0.0027 0.0041 0.0087
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Schistosoma mansoni opsin-like receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0005 0.0012
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0021 0.0027 0.0345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Echinococcus multilocularis serotonin transporter 0.2131 0.4738 0.4888
Onchocerca volvulus 0.0137 0.0287 0.0604
Brugia malayi DNA polymerase delta catalytic subunit 0.0021 0.0027 0.003
Echinococcus granulosus allatostatin A receptor 0.0137 0.0287 0.0287
Brugia malayi AKH receptor 0.0137 0.0287 0.0317
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0083 0.1063
Loa Loa (eye worm) hypothetical protein 0.0183 0.0389 0.0822
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0021 0.0027 0.0372
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.0363 1
Echinococcus multilocularis fmrfamide receptor 0.0137 0.0287 0.0296
Schistosoma mansoni sodium/chloride dependent transporter 0.2131 0.4738 1
Echinococcus granulosus g protein coupled receptor 0.0137 0.0287 0.0287
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0027 0.0041 0.0042
Schistosoma mansoni acetylcholine receptor subunit beta 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Giardia lamblia DNA repair protein RAD52 0.0375 0.0817 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0132
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0001 0.0014
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0001 0.0014
Echinococcus granulosus cpg binding protein 0.0033 0.0054 0.0054
Onchocerca volvulus 0.0012 0.0009 0.0016
Echinococcus granulosus serotonin transporter 0.2131 0.4738 0.4738
Echinococcus granulosus sodium and chloride dependent glycine 0.0362 0.0788 0.0788
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0021 0.0027 0.0345
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.033 0.9066
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0095 0.0193 0.0407
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0019 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0005 0.0006
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0001 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0137 0.0287 0.0606
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0021 0.0027 0.0342
Echinococcus multilocularis neuropeptides capa receptor 0.0137 0.0287 0.0296
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0009 0.0001 0.0017
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0021 0.0027 0.0028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.001
Onchocerca volvulus 0.0027 0.0041 0.0084
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0137 0.0287 0.0287
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0001 0.0014
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0027 0.0041 0.0045
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0001 0.0001
Brugia malayi Dopamine receptor protein 1 0.0137 0.0287 0.0317
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0001 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0005 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0005 0.0012
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0041 0.0045
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0362 0.0788 0.1664
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0019
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0027 0.0041 0.0042
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0083 0.1063
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0041 0.0042
Schistosoma mansoni cpg binding protein 0.0031 0.005 0.0105
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0137 0.0287 0.0287
Schistosoma mansoni nAChR subunit 0.0027 0.0041 0.0087
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0362 0.0788 1
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0009 0.0001 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0041 0.0045
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0362 0.0788 1
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0009 0.0001 0.0003
Toxoplasma gondii DNA polymerase family B protein 0.0021 0.0027 0.0328
Echinococcus granulosus glycine receptor subunit beta 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0015 0.0013 0.0026
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0021 0.0027 0.033
Brugia malayi hypothetical protein 0.0012 0.0009 0.001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0137 0.0287 0.0296
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0001 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0005
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0001 0.0014
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0325 0.4161
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0006
Leishmania major calcium-translocating P-type ATPase 0.0009 0.0001 0.0014
Echinococcus multilocularis neuropeptide receptor A26 0.0137 0.0287 0.0296
Onchocerca volvulus 0.0137 0.0287 0.0604
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0137 0.0287 0.0606
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0137 0.0287 0.0287
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0021 0.0027 0.0342
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0021 0.0027 0.0054
Treponema pallidum sodium- and chloride- dependent transporter 0.2131 0.4738 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0019 0.0021
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0018
Echinococcus granulosus G protein coupled receptor 139 0.0137 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Brugia malayi follicle stimulating hormone receptor 0.0137 0.0287 0.0317
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.0013 0.0015
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0021 0.0027 0.0057
Echinococcus multilocularis glycine receptor subunit beta 0.0027 0.0041 0.0042
Onchocerca volvulus 0.0137 0.0287 0.0604
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0021 0.0027 0.0372
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0041 0.0045
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0021 0.0027 0.0057
Plasmodium vivax DNA polymerase alpha, putative 0.0021 0.0027 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0006
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0027 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0137 0.0287 0.0296
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0021 0.0027 0.0027
Onchocerca volvulus 0.0362 0.0788 0.1662
Leishmania major proton motive ATPase, putative 0.0009 0.0001 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0006
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0027 0.0041 0.0041
Echinococcus granulosus flap endonuclease 1 0.0028 0.0043 0.0043
Schistosoma mansoni coup transcription factor 0.0011 0.0005 0.0012
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0027 0.0041 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0325 0.0707 0.9067
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0001 0.0014
Onchocerca volvulus 0.0137 0.0287 0.0604
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0001 0.0001
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0012 0.0009 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0083 0.1063
Loa Loa (eye worm) hypothetical protein 0.0362 0.0788 0.1664
Onchocerca volvulus 0.0137 0.0287 0.0604
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni flap endonuclease-1 0.0025 0.0037 0.0079
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0041 0.0045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0137 0.0287 0.0296
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.0287 0.0287
Echinococcus multilocularis g protein coupled receptor 0.0137 0.0287 0.0296
Brugia malayi G-protein coupled receptor 0.0137 0.0287 0.0317
Brugia malayi GnHR receptor homolog 0.0137 0.0287 0.0317
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0325 0.0707 0.9067
Echinococcus granulosus sex peptide receptor 0.0137 0.0287 0.0287
Giardia lamblia DNA polymerase alpha subunit A 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0043 0.0557
Echinococcus granulosus g protein coupled receptor 0.0137 0.0287 0.0287
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0043 0.0519
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0043 0.0092
Brugia malayi hypothetical protein 0.0095 0.0193 0.0213
Echinococcus multilocularis sodium and chloride dependent glycine 0.0362 0.0788 0.0813
Treponema pallidum fructose-bisphosphate aldolase 0.032 0.0695 0.1465
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0005 0.0009
Schistosoma mansoni biogenic amine receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0027 0.0041 0.0087
Brugia malayi hypothetical protein 0.0362 0.0788 0.0871
Echinococcus granulosus nAChR subunit 0.0015 0.0013 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.0325 0.4161
Brugia malayi Dopamine receptor 0.0137 0.0287 0.0317
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.004
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0021 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0001 0.0002
Trichomonas vaginalis DNA polymerase II, putative 0.0021 0.0027 0.0372
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0362 0.0788 0.0788
Schistosoma mansoni myosin xvIII 0.0137 0.0287 0.0606
Leishmania major C-8 sterol isomerase-like protein 0.0358 0.078 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0137 0.0287 0.0287
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0021 0.0027 0.0345
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0027 0.0041 0.0087
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0362 0.0788 0.1664
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0009 0.0001 0.0014
Brugia malayi hypothetical protein 0.0137 0.0287 0.0317
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0027 0.0041 0.0087
Brugia malayi ORL1-like opioid receptor 0.0137 0.0287 0.0317
Schistosoma mansoni hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni neuropeptide receptor 0.0137 0.0287 0.0606
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.0287 0.0606
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0027 0.0041 0.0045
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0021 0.0027 0.0316
Onchocerca volvulus 0.0031 0.005 0.0103
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0021 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0137 0.0287 0.0606
Loa Loa (eye worm) GABA receptor subunit 0.0015 0.0013 0.0028
Schistosoma mansoni eyes absent homolog 0.0095 0.0193 0.0407
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Plasmodium vivax copper-transporting ATPase, putative 0.0009 0.0001 0.0014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0021 0.0027 0.0028
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0037 0.0063 0.0132
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0137 0.0287 0.0606
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0101 0.0111
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0021 0.0027 0.0345
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0101 0.0213
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0362 0.0788 0.0813
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0027 0.0041 0.0041
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0137 0.0287 0.0606
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0021 0.0027 0.0342
Schistosoma mansoni sodium/chloride dependent transporter 0.0362 0.0788 0.1664
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0083 0.1063
Brugia malayi Cation transporter family protein 0.0027 0.0041 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0005 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0028
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0043 0.0537
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0001 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0137 0.0287 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0534 0.1173 0.121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0027 0.0041 0.0045
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.0287 0.0287
Schistosoma mansoni neuropeptide F-like receptor 0.0137 0.0287 0.0606
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0013 0.0015
Echinococcus multilocularis somatostatin receptor 0.0137 0.0287 0.0296
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0019 0.004
Onchocerca volvulus 0.0137 0.0287 0.0604
Echinococcus granulosus tachykinin peptides receptor 99D 0.0137 0.0287 0.0287
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0021 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0001 0.0002
Leishmania major P-type H -ATPase, putative 0.0009 0.0001 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0005 0.0012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.005 0.0105
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0041 0.0087
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0005 0.0012
Onchocerca volvulus 0.2131 0.4738 1
Schistosoma mansoni amine GPCR 0.0312 0.0677 0.1429
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358 0.078 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0362 0.0788 0.0871
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0005
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0021 0.0027 0.0345
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.0695 0.8504
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0362 0.0788 0.0871
Echinococcus multilocularis g protein coupled receptor 0.0137 0.0287 0.0296
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.033 0.9066
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0137 0.0287 0.0317
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0005 0.0009
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0137 0.0287 0.0604
Brugia malayi hypothetical protein 0.0009 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0137 0.0287 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0001 0.0003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0041 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Schistosoma mansoni acetylcholine receptor-related 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0001 0.0002
Brugia malayi DNA polymerase family B containing protein 0.0021 0.0027 0.003
Toxoplasma gondii hypothetical protein 0.0362 0.0788 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0112 0.1404
Schistosoma mansoni amine GPCR 0.0137 0.0287 0.0606
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0027 0.0041 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.0137 0.0287 0.0296
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0362 0.0788 0.0788
Echinococcus multilocularis G protein coupled receptor 139 0.0137 0.0287 0.0296
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Echinococcus multilocularis GPCR, family 2 0.0017 0.0019 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni histamine h1 receptor 0.0137 0.0287 0.0606
Echinococcus multilocularis neuropeptide FF receptor 2 0.0137 0.0287 0.0296
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0015 0.0013 0.0015
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0001 0.0002
Schistosoma mansoni cpg binding protein 0.0033 0.0054 0.0114
Brugia malayi excitatory GABA receptor EXP-1A 0.0027 0.0041 0.0045
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0012 0.0009 0.0009
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0001 0.0014
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Echinococcus multilocularis fmrfamide receptor 0.0137 0.0287 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.1667 0.1719
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0021 0.0027 0.0372
Onchocerca volvulus DNA polymerase homolog 0.0021 0.0027 0.0054
Loa Loa (eye worm) G-protein coupled receptor 0.0137 0.0287 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0127 0.0269
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Brugia malayi Sodium:neurotransmitter symporter family protein 0.2131 0.4738 0.5233
Brugia malayi nuclear receptor NHR-88 0.0011 0.0005 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0063 0.0069
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0041 0.0041
Echinococcus granulosus alpha 1A adrenergic receptor 0.0137 0.0287 0.0287
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0041 0.0045
Plasmodium falciparum transporter, putative 0.0362 0.0788 1
Echinococcus multilocularis allatostatin A receptor 0.0137 0.0287 0.0296
Leishmania major mitochondrial DNA polymerase beta 0.0325 0.0707 0.9067
Echinococcus granulosus dnaJ subfamily B 0.0441 0.0965 0.0965
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0375 0.0817 1
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0011 0.0006 0.0014
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0027 0.0041 0.0042
Onchocerca volvulus 0.0137 0.0287 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0087
Echinococcus granulosus somatostatin receptor 0.0137 0.0287 0.0287
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0027 0.0041 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0137 0.0287 0.0606
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2131 0.4738 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0027 0.0041 0.0087
Plasmodium vivax amine transporter, putative 0.0362 0.0788 1
Brugia malayi hypothetical protein 0.0012 0.0009 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.0287 0.0606
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Echinococcus multilocularis sodium and chloride dependent glycine 0.0362 0.0788 0.0813
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0021 0.0027 0.0028
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0005 0.0012
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0021 0.0027 0.0027
Schistosoma mansoni opsin-like receptor 0.0137 0.0287 0.0606
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0362 0.0788 0.1664
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.0287 0.0296
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0362 0.0788 0.1664
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0001 0.0014
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Schistosoma mansoni neuropeptide receptor 0.0137 0.0287 0.0606
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.0695 1
Schistosoma mansoni amine GPCR 0.0137 0.0287 0.0606
Echinococcus granulosus neuropeptides capa receptor 0.0137 0.0287 0.0287
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0005 0.0012
Leishmania major copper-transporting ATPase-like protein, putative 0.0009 0.0001 0.0014
Loa Loa (eye worm) acetylcholine receptor protein 0.0012 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0137 0.0287 0.0606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0014
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0009 0.0018
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0009 0.0001 0.0017

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 188 nM Binding affinity of the compound to Dopamine receptor D2 was determined ChEMBL. 11354362
Ki (binding) = 188 nM Binding affinity of the compound to Dopamine receptor D2 was determined ChEMBL. 11354362
Ki (binding) = 250 nM Binding affinity of the compound to Dopamine receptor D4 was determined ChEMBL. 11354362
Ki (binding) = 250 nM Binding affinity of the compound to Dopamine receptor D4 was determined ChEMBL. 11354362
Ki (binding) = 460 nM Binding affinity of the compound to 5-hydroxytryptamine 1A receptor was determined ChEMBL. 11354362
Ki (binding) = 460 nM Binding affinity of the compound to 5-hydroxytryptamine 1A receptor was determined ChEMBL. 11354362

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.