Detailed information for compound 1460761

Basic information

Technical information
  • TDR Targets ID: 1460761
  • Name: (3R,3aS,7R,7aS)-7-ethyl-2-(phenylmethyl)-3-[4 -(trifluoromethyl)phenyl]-3a,6,7,7a-tetrahydr o-3H-isoindol-1-one
  • MW: 399.449 | Formula: C24H24F3NO
  • H donors: 0 H acceptors: 1 LogP: 5.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H]1CC=C[C@H]2[C@H]1C(=O)N([C@H]2c1ccc(cc1)C(F)(F)F)Cc1ccccc1
  • InChi: 1S/C24H24F3NO/c1-2-17-9-6-10-20-21(17)23(29)28(15-16-7-4-3-5-8-16)22(20)18-11-13-19(14-12-18)24(25,26)27/h3-8,10-14,17,20-22H,2,9,15H2,1H3/t17-,20+,21+,22+/m1/s1
  • InChiKey: ZJEILNFETXCMAH-MNAPGUCWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,3aS,7R,7aS)-2-(benzyl)-7-ethyl-3-[4-(trifluoromethyl)phenyl]-3a,6,7,7a-tetrahydro-3H-isoindol-1-one
  • SMR000465392
  • MLS000882818

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans lipase LipD 0.0038 0.0097 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3788 0.3783
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Onchocerca volvulus 0.0155 0.0634 0.4752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.4028
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0097 0.0855
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0286 0.1237 0.2715
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1649 0.752 0.7518
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1238 0.2606
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0256 0.1101 0.1094
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.1155 0.1701
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0863 0.6743
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Loa Loa (eye worm) phosphatidylinositol 3 0.1001 0.4534 0.6711
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0256 0.1101 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0008 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Toxoplasma gondii FATC domain-containing protein 0.0396 0.1746 0.4767
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0097 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0157 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Loa Loa (eye worm) hypothetical protein 0.006 0.0198 0.0281
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0051 0.0096
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0086 0.0078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0025 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Entamoeba histolytica hypothetical protein 0.0867 0.3914 0.8353
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0138 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0197 0.028
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Trichomonas vaginalis conserved hypothetical protein 0.0438 0.1939 0.4111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.3229 0.688
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0423 0.1868 0.3959
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Entamoeba histolytica hypothetical protein 0.0396 0.1746 0.3697
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0157 0.1231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0678 0.3045 0.3045
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0155 0.0634 0.0626
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0612 0.2738 0.6768
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi N-terminal motif family protein 0.0218 0.0925 0.0925
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0157 0.041
Toxoplasma gondii exonuclease III APE 0.0023 0.0025 0.0046
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Loa Loa (eye worm) hypothetical protein 0.0438 0.1939 0.2863
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Echinococcus multilocularis 0.0155 0.0634 0.0626
Echinococcus granulosus serine protein kinase ATM 0.0396 0.1746 0.174
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0273 0.0273
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0718 0.3229 0.688
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0086 0.0078
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0273 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Toxoplasma gondii target of rapamycin (TOR), putative 0.081 0.3655 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0155 0.0634 0.0626
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0867 0.3914 0.8353
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.1033 0.2164
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1357 0.2001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0634 0.0626
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.174
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0423 0.1868 0.3959
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0438 0.1939 0.5295
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0256 0.1101 1
Brugia malayi hypothetical protein 0.0027 0.0044 0.0044
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.2278 0.4838
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0878 0.3968 0.8468
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0051 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.012 0.0113
Onchocerca volvulus 0.0038 0.0097 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Schistosoma mansoni hypothetical protein 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Leishmania major phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.1868 0.1868
Echinococcus granulosus neuropeptide s receptor 0.0568 0.2536 0.253
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1033 0.4681 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0893 0.4033 0.5968
Onchocerca volvulus 0.0155 0.0634 0.4752
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0155 0.0634 0.5656
Mycobacterium ulcerans hypothetical protein 0.0038 0.0097 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0025 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0086 0.0215
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.1383
Echinococcus multilocularis neuropeptide receptor A26 0.0568 0.2536 0.253
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0584 0.0855
Toxoplasma gondii ABC1 family protein 0.0038 0.0097 0.0244
Brugia malayi MH2 domain containing protein 0.0144 0.0584 0.0584
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.1483 0.6752 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0634 0.6011
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0086 0.0078
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Loa Loa (eye worm) hypothetical protein 0.0355 0.1557 0.2296
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Loa Loa (eye worm) hypothetical protein 0.0241 0.1033 0.1519
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0157 0.0285
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0097 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Loa Loa (eye worm) beta-lactamase 0.0038 0.0097 0.0132
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0423 0.1868 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0935 0.1954
Leishmania major hypothetical protein, conserved 0.0155 0.0634 0.1383
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Mycobacterium leprae Probable lipase LipE 0.0038 0.0097 0.1422
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.4534 0.9684
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Trypanosoma cruzi target of rapamycin kinase 3 0.0827 0.3732 0.3727
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0893 0.4033 0.8894
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0097 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.2426 0.5156
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Onchocerca volvulus 0.0286 0.1238 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1078 0.1587
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.4111
Brugia malayi cytochrome P450 0.0019 0.0008 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0097 0.0855
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1033 0.4681 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0155 0.0634 0.0626
Brugia malayi hypothetical protein 0.0043 0.012 0.012
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0097 0.0855
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.011 0.011
Echinococcus granulosus GPCR family 2 0.0019 0.0008 0.0000061935
Brugia malayi Pre-SET motif family protein 0.0251 0.1078 0.1078
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0827 0.3732 0.8229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.1033 0.2164
Brugia malayi hypothetical protein 0.0148 0.0602 0.0602
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Loa Loa (eye worm) RNA binding protein 0.0076 0.0273 0.0393
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0256 0.1101 0.1101
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Brugia malayi Cytochrome P450 family protein 0.006 0.0197 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0097 0.0855
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0025 0.5
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0678 0.3045 0.4503
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Leishmania major phosphatidylinositol 3-kinase, putative 0.0256 0.1101 0.2416
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0157 0.0285
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1649 0.752 0.7518
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0086 0.0078
Trichomonas vaginalis esterase, putative 0.0038 0.0097 0.0155
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0198 0.0198
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0423 0.1868 0.1862
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0138 0.0281
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0025 0.0017
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0423 0.1868 0.3959
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Loa Loa (eye worm) phosphatidylinositol kinase 0.0155 0.0634 0.0928
Mycobacterium ulcerans beta-lactamase 0.0038 0.0097 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0198 0.0281
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Leishmania major hypothetical protein, conserved 0.0038 0.0097 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0256 0.1101 0.2312
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0241 0.1033 0.1026
Echinococcus multilocularis Zinc finger, PHD finger 0.0256 0.1101 0.1094
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.1225 0.2579
Brugia malayi beta-lactamase 0.0038 0.0097 0.0097
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0157 0.041
Loa Loa (eye worm) acetyltransferase 0.0175 0.0727 0.1066
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0616 0.2759 0.2759
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0778 0.3505 0.7474
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1357 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Plasmodium vivax SET domain protein, putative 0.0036 0.0086 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Schistosoma mansoni hypothetical protein 0.0283 0.1225 0.1219
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0827 0.3732 0.8229
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Leishmania major phosphatidylinositol kinase, putative 0.0155 0.0634 0.1383
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0273 0.0393
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1649 0.752 0.7518
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Echinococcus multilocularis GPCR, family 2 0.0019 0.0008 0.0000061935
Onchocerca volvulus 0.0038 0.0097 0.0092
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2188 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0256 0.1101 0.1094
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.012 0.0113
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0893 0.4033 0.8894
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0155 0.0634 0.1308
Loa Loa (eye worm) hypothetical protein 0.0155 0.0634 0.0928
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0256 0.1101 0.1621
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Entamoeba histolytica protein kinase rad3, putative 0.0396 0.1746 0.3697
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Brugia malayi RNA binding protein 0.0076 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0008 0.0000091757
Schistosoma mansoni hypothetical protein 0.0043 0.012 0.0113
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0000091757
Echinococcus granulosus tar DNA binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0893 0.4033 0.8608
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1033 0.4681 0.4681
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0025 0.0037
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0321 0.1401 0.3433
Echinococcus multilocularis geminin 0.0175 0.0728 0.0721
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0155 0.0634 0.1308
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0041 0.011 0.0151
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0584 0.0855
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0268 0.1155 0.1148
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0097 0.0097
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Loa Loa (eye worm) hypothetical protein 0.0218 0.0925 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0609 0.2728 0.5805
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Echinococcus granulosus neuropeptide receptor A26 0.0568 0.2536 0.253
Giardia lamblia Phosphatidylinositol 4-kinase 0.0155 0.0634 0.1519
Brugia malayi TAR-binding protein 0.0076 0.0273 0.0273
Plasmodium vivax hypothetical protein 0.0155 0.0634 0.5656
Echinococcus multilocularis serine protein kinase ATM 0.0396 0.1746 0.174
Brugia malayi FAT domain containing protein 0.0283 0.1225 0.1225
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0053
Echinococcus granulosus geminin 0.0175 0.0728 0.0721
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Giardia lamblia Hypothetical protein 0.0155 0.0634 0.1519
Brugia malayi Pre-SET motif family protein 0.0036 0.0086 0.0086
Giardia lamblia GTOR 0.0893 0.4033 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0893 0.4033 0.8608
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.0634 0.1308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0727 0.0719
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0097 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0198 0.0198
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.1049 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0396 0.1746 0.174
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.0626
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0116
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0097 0.1422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1033 0.4681 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0155 0.0634 0.1383
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0704 0.0697
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0396 0.1746 0.174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0097 0.0855
Leishmania major hypothetical protein, unknown function 0.0155 0.0634 0.1383
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0037
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0025 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0051 0.4881
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1033 0.4681 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.8894
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0893 0.4033 0.8894
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0044 0.008
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0727 0.0719
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.012 0.0113
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0256 0.1101 0.2312
Loa Loa (eye worm) hypothetical protein 0.0283 0.1225 0.1805
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0893 0.4033 0.4033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0256 0.1101 0.2312
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0256 0.1101 0.1094
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0634 0.5656
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0138 0.0242
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0155 0.0634 0.0626
Loa Loa (eye worm) hypothetical protein 0.0065 0.0221 0.0316
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0097 0.0669
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0396 0.1746 0.174
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.008 0.0072
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0025 0.0163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0097 0.0855
Leishmania major cytochrome p450-like protein 0.0028 0.0051 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0504 0.2241 0.4934
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0025 0.1904
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0097 0.0132
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0155 0.0634 0.0626
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0778 0.3505 0.7474
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.2618 0.557
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0925 0.7278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Schistosoma mansoni hypothetical protein 0.0041 0.011 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0893 0.4033 0.4028
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0634 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.0099
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.3841
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0396 0.1746 0.2577
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0893 0.4033 0.4028
Echinococcus multilocularis neuropeptide s receptor 0.0568 0.2536 0.253
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Onchocerca volvulus 0.0038 0.0097 0.0092
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0282 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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