Detailed information for compound 1474438

Basic information

Technical information
  • TDR Targets ID: 1474438
  • Name: 9-(3-piperidin-1-ylpropoxy)-5H-benzo[b][1]ben zothiepin-6-one
  • MW: 367.504 | Formula: C22H25NO2S
  • H donors: 0 H acceptors: 1 LogP: 4.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Cc2ccccc2Sc2c1ccc(c2)OCCCN1CCCCC1
  • InChi: 1S/C22H25NO2S/c24-20-15-17-7-2-3-8-21(17)26-22-16-18(9-10-19(20)22)25-14-6-13-23-11-4-1-5-12-23/h2-3,7-10,16H,1,4-6,11-15H2
  • InChiKey: HVBFDMQTIYPSNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-[3-(1-piperidyl)propoxy]-5H-benzo[b][1]benzothiepin-6-one
  • 9-(3-piperidinopropoxy)-5H-benzo[b][1]benzothiepin-6-one
  • AE-641/30155016

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0003
Echinococcus granulosus twinkle protein mitochondrial 0.0012 0.0006 0.0006
Brugia malayi Muscleblind-like protein 0.0456 0.3595 0.5823
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0053 0.0178
Brugia malayi hypothetical protein 0.005 0.0312 0.0505
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0053 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0049 0.0305 0.1169
Onchocerca volvulus 0.0012 0.0008 0.0012
Brugia malayi metallo-beta-lactamase superfamily protein 0.0049 0.0305 0.0493
Brugia malayi transcription factor E74 isoform 0.0011 0.0002 0.0003
Schistosoma mansoni ets-related 0.0238 0.1831 0.1831
Leishmania major mitochondrial DNA polymerase beta 0.0326 0.2549 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0084 0.0593 0.2305
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0053 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0106 0.0172
Brugia malayi serine/threonine-protein kinase plk-2 0.0288 0.224 0.3628
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0175 0.0175
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0049 0.0305 0.0305
Brugia malayi MH1 domain containing protein 0.0014 0.0021 0.0034
Schistosoma mansoni hypothetical protein 0.0289 0.2247 0.2247
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0071 0.0283
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0079 0.0031
Trypanosoma brucei unspecified product 0.0014 0.0027 0.0063
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0012 0.0008 0.0012
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.0305 0.1331
Schistosoma mansoni cpg binding protein 0.0093 0.0659 0.0659
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0002 0.0003
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0012 0.0006 0.0009
Mycobacterium ulcerans 5'-3' exonuclease 0.0039 0.0228 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0054 0.0343 0.132
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.0543 0.0879
Schistosoma mansoni smad1 5 8 and 0.0025 0.0111 0.0111
Mycobacterium ulcerans glyoxalase II, GloB 0.0049 0.0305 0.0284
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0283
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.017 0.1288 0.1288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0747 0.121
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0002 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0079 0.0281
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.1122 0.8985 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0305 0.1331
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0053 0.0053
Brugia malayi MH1 domain containing protein 0.0014 0.0021 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0876 0.6995 0.6995
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0079 0.0128
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Entamoeba histolytica serine/threonine protein kinase, putative 0.0288 0.224 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0079 0.032
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0012 0.0008 0.0008
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0053 0.0364
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0002 0.0002
Echinococcus granulosus dna polymerase eta 0.0021 0.0079 0.0079
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0012 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0273 0.2115 0.9437
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0175 0.0175
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0228 0.0866
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0116 0.0846 0.3755
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0116 0.0846 0.0846
Mycobacterium tuberculosis Possible hydrolase 0.0049 0.0305 0.0284
Schistosoma mansoni smad 0.0025 0.0111 0.0111
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0273 0.2115 0.9437
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0175 0.0175
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0053 0.0149
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0012 0.0008 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0012 0.0008 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 0.2549 0.8345
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0532 0.2064
Echinococcus granulosus thyrotropin releasing hormone receptor 0.026 0.2014 0.2014
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Trypanosoma cruzi glyoxalase II 0.0049 0.0305 0.1169
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0116 0.0846 0.3755
Brugia malayi MH2 domain containing protein 0.0364 0.2855 0.4624
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0189 0.0189
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0049 0.0305 0.5072
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.0305 0.1331
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0012 0.0008 0.0008
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0106 0.0106
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0127 0.0205
Leishmania major DNA polymerase kappa, putative 0.0021 0.0079 0.0281
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.1122 0.8985 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0079 0.0128
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.1364 0.2209
Entamoeba histolytica alkyl sulfatase, putative 0.0049 0.0305 0.1331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Schistosoma mansoni elf1 0.0011 0.0002 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0012 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Schistosoma mansoni ferritin 0.0017 0.0051 0.0051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0053 0.0178
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0456 0.3595 0.5823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Leishmania major hypothetical protein, conserved 0.0077 0.0532 0.2064
Echinococcus multilocularis dna polymerase eta 0.0021 0.0079 0.0079
Loa Loa (eye worm) nuclear factor I 0.0014 0.0021 0.0034
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0273 0.2115 0.3425
Schistosoma mansoni beta-hexosaminidase B 0.0273 0.2115 0.2115
Echinococcus multilocularis cpg binding protein 0.0093 0.0659 0.0659
Plasmodium falciparum telomerase reverse transcriptase 0.0084 0.0593 1
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0049 0.0305 0.0284
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0053 0.0149
Schistosoma mansoni hypothetical protein 0.0033 0.0175 0.0175
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Loa Loa (eye worm) hypothetical protein 0.0077 0.0532 0.0862
Echinococcus multilocularis Smad4 0.0025 0.0111 0.0111
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0053 0.0053
Leishmania major metallo-beta-lactamase family protein-like protein 0.0049 0.0305 0.1169
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.085
Echinococcus granulosus muscleblind protein 0.0456 0.3595 0.3595
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Brugia malayi hypothetical protein 0.0212 0.1626 0.2633
Loa Loa (eye worm) hypothetical protein 0.0212 0.1626 0.2633
Mycobacterium ulcerans hydrolase 0.0049 0.0305 0.0284
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.2855 0.4624
Schistosoma mansoni tsg101-related 0.0177 0.1339 0.1339
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.224 1
Mycobacterium ulcerans hypothetical protein 0.0172 0.13 0.1398
Brugia malayi hypothetical protein 0.011 0.0798 0.1292
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0281 0.1077
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0175 0.0284
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0054 0.0343 0.2695
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0049 0.0305 0.1331
Entamoeba histolytica hypothetical protein 0.011 0.0798 0.3539
Plasmodium falciparum cytosolic glyoxalase II 0.0049 0.0305 0.5072
Echinococcus granulosus beta hexosaminidase subunit alpha 0.017 0.1288 0.1288
Brugia malayi CXXC zinc finger family protein 0.0088 0.0619 0.1002
Schistosoma mansoni calpain-7 (C02 family) 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0071 0.0482 0.0781
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0079 0.0281
Schistosoma mansoni gabp alpha 0.0078 0.0543 0.0543
Brugia malayi DNA polymerase I family protein 0.0016 0.004 0.0064
Onchocerca volvulus Hexosaminidase D homolog 0.0063 0.0422 0.0683
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0063 0.0422 0.0683
Brugia malayi hypothetical protein 0.0049 0.0305 0.0493
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.0305 0.1331
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0012 0.0008 0.0008
Entamoeba histolytica metallo-beta-lactamase family protein 0.0049 0.0305 0.1331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0012 0.0008 0.0008
Schistosoma mansoni flap endonuclease-1 0.0048 0.0301 0.0301
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0116 0.0846 0.0846
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0049 0.0305 0.1169
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0002 0.0002
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0104 0.0747 0.121
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0532 0.1722
Schistosoma mansoni tsg101-related 0.0177 0.1339 0.1339
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0002 0.0003
Mycobacterium leprae POSSIBLE HYDROLASE 0.0049 0.0305 0.0284
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0116 0.0846 0.137
Echinococcus multilocularis expressed protein 0.0012 0.0008 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0175 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Brugia malayi hypothetical protein 0.0077 0.0532 0.0862
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0049 0.0305 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0846 0.3755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0068 0.0459 0.1776
Brugia malayi Telomerase reverse transcriptase 0.0225 0.1728 0.2799
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0288 0.224 0.224
Echinococcus granulosus beta hexosaminidase subunit beta 0.0273 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0049 0.0305 0.1331
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0305 0.1331
Plasmodium vivax telomerase reverse transcriptase, putative 0.0084 0.0593 1
Onchocerca volvulus Putative hydrolase PNKD 0.0049 0.0305 0.0493
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1159 0.4531
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0012 0.0008 0.0008
Trichomonas vaginalis beta-hexosaminidase, putative 0.017 0.1288 0.5733
Onchocerca volvulus 0.0775 0.6175 1
Loa Loa (eye worm) hypothetical protein 0.0456 0.3595 0.5823
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0079 0.0281
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0532 0.4214
Loa Loa (eye worm) hypothetical protein 0.018 0.1364 0.2209
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0012 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0049 0.0305 0.0284
Loa Loa (eye worm) hypothetical protein 0.0049 0.0305 0.0493
Trypanosoma cruzi polo-like protein kinase, putative 0.0288 0.224 0.8786
Schistosoma mansoni hypothetical protein 0.0049 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0063 0.0422 0.0683
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0053 0.0053
Echinococcus multilocularis ETHE1 protein 0.0049 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.011 0.0798 0.0798
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0012 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0034
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.224 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0116 0.0846 0.0846
Loa Loa (eye worm) Smad1 0.0025 0.0111 0.018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0678 0.0678
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0053 0.0053
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0212 0.1626 0.1626
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0086 0.0086
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0012 0.0008 0.0008
Trichomonas vaginalis beta-hexosaminidase, putative 0.0063 0.0422 0.1856
Schistosoma mansoni smad1 5 8 and 0.0025 0.0111 0.0111
Echinococcus multilocularis dnaJ subfamily B 0.1248 1 1
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.004 0.0105
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.004 0.0105
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Echinococcus granulosus kelch ECH associated protein 1 like 0.0288 0.224 0.224
Schistosoma mansoni hypothetical protein 0.0033 0.0175 0.0175
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.2855 0.4624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0049 0.0305 0.0305
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0049 0.0305 0.0305
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0116 0.0846 0.33
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0049 0.0305 0.0976
Schistosoma mansoni cpg binding protein 0.0088 0.0619 0.0619
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0305 0.1331
Brugia malayi MH2 domain containing protein 0.0025 0.0111 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0305 0.1331
Schistosoma mansoni DNA polymerase I 0.0016 0.004 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0747 0.121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0053 0.0086
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0055 0.0357 1
Leishmania major hypothetical protein, conserved 0.0049 0.0305 0.1169
Treponema pallidum ribonuclease Z 0.0049 0.0305 0.8291
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0049 0.0305 0.2387
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0003
Schistosoma mansoni ferritin 0.0017 0.0051 0.0051
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.081 0.6457 0.7171
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0305 0.1331
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0053 0.0178
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0012 0.0008 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.2549 1
Mycobacterium ulcerans beta lactamase-like protein 0.0049 0.0305 0.0284
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0053 0.0203
Plasmodium falciparum plastid replication-repair enzyme 0.0016 0.004 0.0548
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0053 0.0086
Trichomonas vaginalis DNA polymerase I, putative 0.0016 0.004 0.0144
Schistosoma mansoni apoferritin-2 0.0017 0.0051 0.0051
Brugia malayi ubiquitin specific protease 14 0.0012 0.0008 0.0012
Echinococcus multilocularis flap endonuclease 1 0.0054 0.0343 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Mycobacterium ulcerans hypothetical protein 0.0049 0.0305 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0049 0.0305 0.1169
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0111 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0012 0.0012
Brugia malayi MH1 domain containing protein 0.0025 0.0111 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0189 0.0189
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0623
Leishmania major metallo-beta-lactamase family-like protein 0.0049 0.0305 0.1169
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0049 0.0305 0.1169
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0002 0.0003
Echinococcus multilocularis smad 0.0025 0.0111 0.0111
Trichomonas vaginalis beta-hexosaminidase B, putative 0.017 0.1288 0.5733
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.1252 1
Echinococcus granulosus ubiquitin specific protease 41 0.0116 0.0846 0.0846
Entamoeba histolytica hypothetical protein 0.011 0.0798 0.3539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Schistosoma mansoni hypothetical protein 0.0049 0.0305 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Echinococcus granulosus kelch ECH associated protein 1 like 0.0288 0.224 0.224
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.224 1
Toxoplasma gondii helicase, putative 0.0016 0.004 0.0258
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0228 0.3756
Echinococcus granulosus Smad4 0.0025 0.0111 0.0111
Schistosoma mansoni calpain-7 (C02 family) 0.0012 0.0008 0.0008
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0129 0.021
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0012 0.0008 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0012 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Brugia malayi hypothetical protein 0.0012 0.0008 0.0012
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0273 0.2115 0.9437
Brugia malayi Smad1 0.0025 0.0111 0.018
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.0305 0.1331
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0305 0.0284
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0212 0.1626 0.1626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0079 0.0281
Trypanosoma cruzi polo-like protein kinase, putative 0.0288 0.224 0.8786
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0175 0.0284
Schistosoma mansoni hypothetical protein 0.1248 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0079 0.028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0079 0.0079
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0012 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Mycobacterium tuberculosis Conserved protein 0.0049 0.0305 0.0284
Schistosoma mansoni hypothetical protein 0.0034 0.0189 0.0189
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0068 0.0459 0.1482
Trichomonas vaginalis apoptosis inducing factor, putative 0.0049 0.0305 0.1331
Mycobacterium ulcerans hypothetical protein 0.0049 0.0305 0.0284
Echinococcus multilocularis muscleblind protein 1 0.0456 0.3595 0.3595
Mycobacterium ulcerans lipoprotein LpqF 0.0389 0.3053 0.336
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0116 0.0846 0.33
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0049 0.0305 0.1169
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0053 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Echinococcus multilocularis muscleblind protein 0.0456 0.3595 0.3595
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0079 0.032
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0002 0.0003
Echinococcus multilocularis kelch ECH associated protein 1 0.0288 0.224 0.224
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.0305 0.1331
Entamoeba histolytica hypothetical protein 0.011 0.0798 0.3539
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0016 0.004 0.0126
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0116 0.0846 0.137
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0012 0.0008 0.0008
Mycobacterium tuberculosis Possible hydrolase 0.0049 0.0305 0.0284
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0281 0.1077
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0197 0.0747
Echinococcus multilocularis GPCR, family 2 0.0033 0.0175 0.0175
Brugia malayi N-terminal motif family protein 0.018 0.1364 0.2209
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0002
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0053 0.0053
Giardia lamblia Telomerase catalytic subunit 0.0084 0.0593 0.2624
Entamoeba histolytica alkyl sulfatase, putative 0.0049 0.0305 0.1331
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.2549 1
Echinococcus granulosus protein C ets 2 0.0011 0.0002 0.0002
Plasmodium vivax unspecified product 0.0049 0.0305 0.5072
Echinococcus multilocularis zinc phosphodiesterase 0.0049 0.0305 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0678 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0027 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.026 0.2014 0.2014
Giardia lamblia DINP protein human, muc B family 0.0021 0.0079 0.032
Trypanosoma brucei telomerase reverse transcriptase 0.0084 0.0593 0.1924
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0049 0.0305 0.1169
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.224 1
Echinococcus granulosus kelch ECH associated protein 1 0.0288 0.224 0.224
Trypanosoma brucei glyoxalase II 0.0049 0.0305 0.0976
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Echinococcus granulosus cpg binding protein 0.0093 0.0659 0.0659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0079 0.0079
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0012 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0106 0.0388
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0049 0.0305 0.0305
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0002 0.0002
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0012 0.0008 0.0008
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.026 0.2014 0.2014
Echinococcus granulosus GPCR family 2 0.0033 0.0175 0.0175
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0049 0.0305 0.1331
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0305 0.0284
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0012 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0012 0.0008 0.0008
Onchocerca volvulus 0.0088 0.0619 0.1002
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0079 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0678 0.0678
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0775 0.6175 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0024 0.0106 0.0441
Schistosoma mansoni ferritin light chain 0.0017 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Schistosoma mansoni DNA polymerase eta 0.0021 0.0079 0.0079
Schistosoma mansoni peptidase 0.0013 0.0015 0.0015
Brugia malayi MH1 domain containing protein 0.0025 0.0111 0.018
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.0305 0.1331
Mycobacterium tuberculosis Conserved protein 0.0049 0.0305 0.0284
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.085
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0002 0.0002
Plasmodium vivax plastid replication-repair enzyme, putative 0.0016 0.004 0.0548
Leishmania major telomerase reverse transcriptase, putative 0.0084 0.0593 0.2305
Brugia malayi ethe1-prov protein 0.0049 0.0305 0.0493
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0012 0.0008 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0079 0.0234
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0389 0.3053 0.336
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0012 0.0008 0.0008
Entamoeba histolytica metallo-beta-lactamase family protein 0.0049 0.0305 0.1331
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Brugia malayi Flap endonuclease-1 0.0054 0.0343 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0678 0.1098
Trypanosoma brucei unspecified product 0.0014 0.0027 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Plasmodium falciparum flap endonuclease 1 0.0054 0.0343 0.5727
Echinococcus multilocularis ubiquitin specific protease 41 0.0116 0.0846 0.0846
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0111 0.0111
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0049 0.0305 0.0493
Loa Loa (eye worm) hypothetical protein 0.0067 0.0451 0.0731
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0084 0.0593 0.2305
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Entamoeba histolytica metallo-beta-lactamase family protein 0.0049 0.0305 0.1331
Schistosoma mansoni ferritin 0.0017 0.0051 0.0051
Mycobacterium ulcerans hydrolase 0.0049 0.0305 0.0284
Onchocerca volvulus 0.0012 0.0008 0.0012
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0002 0.0002
Echinococcus multilocularis kelch ECH associated protein 1 0.0288 0.224 0.224
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0283
Schistosoma mansoni ets-related 0.0011 0.0002 0.0002
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.0543 0.0543
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0002 0.0002
Brugia malayi Ets-domain containing protein 0.0078 0.0543 0.0879
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Echinococcus multilocularis Kelch repeat type 1 0.0289 0.2247 0.2247
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.085
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0197 0.0747
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0016 0.004 0.0126
Leishmania major hypothetical protein, conserved 0.0068 0.0459 0.1776
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0116 0.0846 0.0846
Mycobacterium leprae Beta-lactamase-like protein 0.0049 0.0305 0.0284
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0106 0.0106
Mycobacterium ulcerans DNA polymerase I 0.0055 0.0357 0.0342
Loa Loa (eye worm) hypothetical protein 0.0049 0.0305 0.0493
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0228 0.0723
Toxoplasma gondii hypothetical protein 0.0053 0.0336 0.2638
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0079 0.0079
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0012 0.0008 0.0008
Brugia malayi metallo-beta-lactamase superfamily protein 0.0049 0.0305 0.0493
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0049 0.0305 0.0976
Echinococcus granulosus smad 0.0025 0.0111 0.0111
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0175 0.0175
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0012 0.0008 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0111 0.018
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1064 0.473
Brugia malayi Ets-domain containing protein 0.0011 0.0002 0.0003
Loa Loa (eye worm) twinkle helicase 0.0012 0.0006 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0079 0.0281
Trypanosoma brucei unspecified product 0.0021 0.0079 0.0234
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0012 0.0008 0.0008
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0798 0.0798
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0012 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Schistosoma mansoni tsg101-related 0.0144 0.1077 0.1077
Echinococcus granulosus flap endonuclease 1 0.0054 0.0343 0.0343
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0309 0.2411 0.3905
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0012 0.0008 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0012 0.0008 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0532 0.2064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Leishmania major DNA polymerase eta, putative 0.0021 0.0079 0.0281
Echinococcus granulosus ferritin 0.0017 0.0051 0.0051
Toxoplasma gondii RNA-directed DNA polymerase 0.0084 0.0593 0.4706
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0049 0.0305 0.0493
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0283
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0049 0.0305 0.1169
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0012 0.0008 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0798 0.0798
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0106 0.0791
Onchocerca volvulus Serine\/threonine kinase homolog 0.0288 0.224 0.3628
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.224 0.224
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.1413 0.1413
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0012 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0116 0.0846 0.3755
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0027 0.0063
Giardia lamblia Kinase, PLK 0.0288 0.224 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0116 0.0846 0.3755
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.0305 0.1331
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0798 0.0798
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.13 0.1398
Mycobacterium tuberculosis Beta lactamase like protein 0.0049 0.0305 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0049 0.0305 0.2387
Loa Loa (eye worm) hypothetical protein 0.0049 0.0305 0.0493
Mycobacterium ulcerans hydrolase 0.0049 0.0305 0.0284
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0002 0.0003
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0106 0.0106
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0111 0.018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0281 0.1077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0283
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.224 1
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0049 0.0305 0.0493
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0016 0.004 0.0126
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0053 0.0178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0305 0.0284
Schistosoma mansoni hypothetical protein 0.0033 0.0175 0.0175
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0012 0.0008 0.0008
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0013 0.0019 0.0088
Mycobacterium ulcerans hypothetical protein 0.0049 0.0305 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Echinococcus granulosus dna polymerase kappa 0.0021 0.0079 0.0079
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0012 0.0008 0.0008
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.0305 0.1331
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0079 0.0079
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0106 0.0324
Brugia malayi Ets-domain containing protein 0.0078 0.0543 0.0879
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0049 0.0305 0.0305
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0039 0.0228 0.0197
Giardia lamblia Flap structure-specific endonuclease 0.0054 0.0343 0.1503
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0079 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Treponema pallidum DNA polymerase I (polA) 0.0055 0.0357 1
Echinococcus granulosus expressed protein 0.0017 0.0051 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0482 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0086 0.0086
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0012 0.0008 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Schistosoma mansoni zinc phosphodiesterase 0.0049 0.0305 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Loa Loa (eye worm) hypothetical protein 0.0049 0.0305 0.0493
Schistosoma mansoni cpg binding protein 0.0093 0.0659 0.0659
Loa Loa (eye worm) fli-1 protein 0.0238 0.1831 0.2966
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Trypanosoma brucei beta lactamase 0.0389 0.3053 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0284
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0532 0.8953
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0362 0.1397
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0079 0.0234
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0012 0.0008 0.0012
Echinococcus granulosus zinc phosphodiesterase 0.0049 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0012
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0049 0.0305 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0305 0.1331
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1159 0.4531
Echinococcus granulosus ubiquitin specific peptidase c family 0.0012 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1064 0.473
Schistosoma mansoni hypothetical protein 0.0071 0.0482 0.0482
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0053 0.0149
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0054 0.0343 0.132
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0079 0.032
Schistosoma mansoni ferritin 0.0017 0.0051 0.0051
Schistosoma mansoni smad1 5 8 and 0.0025 0.0111 0.0111
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0012 0.0008 0.0008
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0111 0.0111
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0012 0.0008 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0012 0.0008 0.0008
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0012 0.0008 0.0008
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0228 0.0866
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0063 0.0422 0.0683
Loa Loa (eye worm) hypothetical protein 0.0063 0.0422 0.0683
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0079 0.0234
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0079 0.0281
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0389 0.3053 0.336
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0053 0.0179
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0129 0.0129
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0129 0.0129
Schistosoma mansoni apoferritin-2 0.0017 0.0051 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0747 0.121
Entamoeba histolytica hypothetical protein 0.011 0.0798 0.3539
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0055 0.0357 0.0342
Brugia malayi MH2 domain containing protein 0.0025 0.0111 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.224 1
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0012 0.0008 0.0008
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.0543 0.0543
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0049 0.0305 0.1331
Trichomonas vaginalis A-type flavoprotein 0.0049 0.0305 0.1331
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0012 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0106 0.0441
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0116 0.0846 0.0846
Trichomonas vaginalis hypothetical protein 0.0103 0.0746 0.3307
Schistosoma mansoni zinc phosphodiesterase 0.0049 0.0305 0.0305
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0053 0.0178
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0012 0.0008 0.0008
Entamoeba histolytica Flap nuclease, putative 0.0054 0.0343 0.1503
Echinococcus granulosus ETHE1 protein 0.0049 0.0305 0.0305
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0049 0.0305 0.1331
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0012 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Echinococcus multilocularis protein C ets 2 0.0011 0.0002 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0678 0.1098
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.085
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0053 0.0086
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0012 0.0008 0.0008
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0053 0.0178
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0116 0.0846 0.2753
Trypanosoma cruzi glyoxalase II 0.0049 0.0305 0.1169
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0012 0.0008 0.0008
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0008 0.0012
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0049 0.0305 0.0305
Plasmodium vivax flap endonuclease 1, putative 0.0054 0.0343 0.5727
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0079 0.0079
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0049 0.0305 0.1169
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0012 0.0008 0.0008
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0288 0.224 0.8786
Trichomonas vaginalis beta-hexosaminidase, putative 0.017 0.1288 0.5733
Echinococcus multilocularis expressed protein 0.0017 0.0051 0.0051
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0012 0.0008 0.0008
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0035 0.0197 0.0747
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0053 0.0178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0678 0.0678
Onchocerca volvulus 0.0049 0.0305 0.0493
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0079 0.0128
Schistosoma mansoni kinase 0.0146 0.1095 0.1095
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0053 0.0203
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0019 0.0066 0.0468
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0016 0.004 0.0258
Trichomonas vaginalis helicase, putative 0.002 0.0071 0.0283
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0053 0.0178
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0016 0.004 0.0144
Schistosoma mansoni hypothetical protein 0.0049 0.0305 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0197 0.085
Mycobacterium ulcerans hypothetical protein 0.0049 0.0305 0.0284
Onchocerca volvulus 0.0012 0.0008 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0086 0.0086
Trichomonas vaginalis beta-hexosaminidase, putative 0.017 0.1288 0.5733
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0305 0.0284
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0049 0.0305 0.8291
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.224 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0288 0.224 0.224
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0305 0.1331
Onchocerca volvulus 0.0049 0.0305 0.0493
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0305 0.0284
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.1122 0.8985 1
Loa Loa (eye worm) flap endonuclease-1 0.0054 0.0343 0.0556
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0288 0.224 0.3628
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0273 0.2115 0.2115
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0053 0.0179
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0619 0.1002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0053 0.0178
Echinococcus multilocularis twinkle protein, mitochondrial 0.0012 0.0006 0.0006
Schistosoma mansoni beta-hexosaminidase B 0.0273 0.2115 0.2115
Brugia malayi hypothetical protein 0.0775 0.6175 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0079 0.0031
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0228 0.0866
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Schistosoma mansoni Smad4 0.0025 0.0111 0.0111
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0144 0.1077 0.479
Trichomonas vaginalis flap endonuclease-1, putative 0.0054 0.0343 0.1503
Schistosoma mansoni ets 0.0011 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0283
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0086 0.0086
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0071 0.0283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0283
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0228 0.3756
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0053 0.0149
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0049 0.0305 0.0305
Brugia malayi Fli-1 protein 0.0238 0.1831 0.2966
Chlamydia trachomatis DNA polymerase I 0.0055 0.0357 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0054 0.0343 0.1102
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0012 0.0008 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0012 0.0008 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0012 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0197 0.085
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0012 0.0008 0.0008
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.081 0.6457 0.7171
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0281 0.0899
Schistosoma mansoni ferritin light chain 0.0017 0.0051 0.0051
Trichomonas vaginalis ferritin, putative 0.0017 0.0051 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0305 0.1331
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.1159 0.3781
Echinococcus multilocularis ferritin 0.0017 0.0051 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0079 0.0234
Giardia lamblia GTOR 0.0018 0.0053 0.0203
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0532 0.8953
Trypanosoma cruzi glyoxalase II 0.0049 0.0305 0.1169
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0012 0.0008 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0012 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0116 0.0846 0.33
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0002 0.0002
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Schistosoma mansoni hypothetical protein 0.0033 0.0175 0.0175
Trypanosoma brucei polo-like protein kinase 0.0288 0.224 0.7332
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0273 0.2115 0.3425
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0012 0.0008 0.0008
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0055 0.0357 0.0342
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0049 0.0305 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0678 0.0678
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0008 0.0012
Echinococcus multilocularis ets variant gene 4 0.0011 0.0002 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0116 0.0846 0.0846
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0678 0.0678
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0079 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0203
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0002 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0532 0.8953
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0273 0.2115 0.9437
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0012 0.0008 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0012 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0027 0.0063
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0053 0.0178

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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