Detailed information for compound 1485419

Basic information

Technical information
  • TDR Targets ID: 1485419
  • Name: 3-(4-chlorophenyl)sulfonyl-1,6-diethylquinoli n-4-one
  • MW: 375.869 | Formula: C19H18ClNO3S
  • H donors: 0 H acceptors: 3 LogP: 4.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc2c(c1)c(=O)c(cn2CC)S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C19H18ClNO3S/c1-3-13-5-10-17-16(11-13)19(22)18(12-21(17)4-2)25(23,24)15-8-6-14(20)7-9-15/h5-12H,3-4H2,1-2H3
  • InChiKey: MUIAZAAJGBHOKR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-chlorophenyl)sulfonyl-1,6-diethyl-quinolin-4-one
  • 3-(4-chlorophenyl)sulfonyl-1,6-diethyl-4-quinolinone
  • 3-(4-chlorophenyl)sulfonyl-1,6-diethyl-4-quinolone
  • C682-1514
  • NCGC00111635-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0218 0.04 0.5
Trypanosoma brucei aurora B kinase 0.0563 0.1129 0.377
Echinococcus granulosus twitchin 0.0236 0.0438 0.0612
Leishmania major cytochrome p450-like protein 0.0218 0.04 0.1314
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0563 0.1129 0.112
Echinococcus granulosus serotonin transporter 0.028 0.0531 0.0746
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0037 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0362 0.0704 0.2296
Echinococcus granulosus titin 0.0042 0.0027 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0218 0.04 0.5
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0024 0.0116
Echinococcus multilocularis neuroglian 0.0051 0.0046 0.005
Echinococcus multilocularis titin 0.0042 0.0027 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0027 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Loa Loa (eye worm) serotonin transporter b 0.028 0.0531 0.1709
Plasmodium falciparum amino acid transporter, putative 0.0048 0.0039 0.0253
Onchocerca volvulus Serine\/threonine kinase homolog 0.1436 0.2978 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.003 0.0064
Echinococcus granulosus titin 0.0042 0.0027 0.0024
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0053 0.0143
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1436 0.2978 0.4252
Loa Loa (eye worm) TK/ROR protein kinase 0.0045 0.0032 0.0018
Loa Loa (eye worm) hypothetical protein 0.0221 0.0406 0.1283
Entamoeba histolytica protein kinase domain containing protein 0.0563 0.1129 0.377
Schistosoma mansoni septate junction protein 0.0047 0.0037 0.0026
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0051 0.0046 0.0035
Schistosoma mansoni nephrin 0.0227 0.0418 0.0408
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Schistosoma mansoni septate junction protein 0.0047 0.0037 0.0026
Onchocerca volvulus 0.0048 0.0039 0.004
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Echinococcus multilocularis Immunoglobulin 0.0198 0.0358 0.0498
Schistosoma mansoni neuroglian 0.0051 0.0046 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0046 0.0064
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0203 0.0367 0.1152
Toxoplasma gondii aurora kinase 0.0563 0.1129 1
Echinococcus granulosus Immunoglobulin 0.0198 0.0358 0.0498
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0218 0.04 0.5
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0218 0.04 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.0046 0.005
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0053 0.0061
Entamoeba histolytica serine/threonine protein kinase, putative 0.1436 0.2978 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0563 0.1129 1
Echinococcus multilocularis neuroglian 0.0222 0.0409 0.0571
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0037 0.0033
Echinococcus multilocularis aurora kinase A 0.0563 0.1129 0.1603
Brugia malayi Integrin beta pat-3 precursor 0.0276 0.0523 0.1682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0015 0.0051
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0048 0.0039 0.004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Toxoplasma gondii hypothetical protein 0.0048 0.0039 0.0253
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0218 0.04 0.5
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0039 0.0028
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.0203 0.0367 0.1152
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0028 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0039 0.0028
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Onchocerca volvulus 0.0048 0.0039 0.004
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0218 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0198 0.0358 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Echinococcus granulosus neuroglian 0.0051 0.0046 0.005
Giardia lamblia Aurora kinase 0.0563 0.1129 0.3679
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.028 0.0531 0.0521
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0198 0.0358 0.0348
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0028 0.0004
Brugia malayi Cytochrome P450 family protein 0.0882 0.1805 0.6026
Onchocerca volvulus 0.1026 0.211 0.706
Schistosoma mansoni hypothetical protein 0.0218 0.04 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0007 0.0023
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.003 0.0028
Echinococcus granulosus neuroglian 0.0222 0.0409 0.0571
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0048 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.028 0.0531 0.1709
Trypanosoma brucei polo-like protein kinase 0.1436 0.2978 1
Brugia malayi serine/threonine-protein kinase plk-2 0.1436 0.2978 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0218 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Echinococcus granulosus roundabout 2 0.0249 0.0465 0.0652
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.003 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0218 0.04 0.5
Schistosoma mansoni cell adhesion molecule 0.0051 0.0046 0.0035
Brugia malayi Prion-like- 0.0047 0.0037 0.0033
Echinococcus granulosus hemicentin 1 0.0047 0.0037 0.0037
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0053 0.0143
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Loa Loa (eye worm) CYP4Cod1 0.0362 0.0704 0.2296
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0218 0.04 0.5
Loa Loa (eye worm) cytochrome P450 0.0218 0.04 0.1265
Mycobacterium leprae Conserved hypothetical protein 0.0218 0.04 0.5
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0048 0.0039 0.5
Echinococcus granulosus lachesin 0.0047 0.0037 0.0037
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0563 0.1129 0.377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0036 0.0121
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0218 0.04 0.1314
Treponema pallidum sodium- and chloride- dependent transporter 0.028 0.0531 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0048 0.0039 0.0041
Schistosoma mansoni titin 0.0042 0.0027 0.0016
Onchocerca volvulus Tyrosine kinase homolog 0.107 0.2204 0.7379
Brugia malayi hypothetical protein 0.0203 0.0367 0.1152
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0218 0.04 0.5
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0053 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.1436 0.2978 0.297
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Brugia malayi cytochrome P450 0.0218 0.04 0.1265
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0218 0.04 0.5
Schistosoma mansoni cell adhesion molecule 0.0225 0.0415 0.0405
Onchocerca volvulus 0.028 0.0531 0.1709
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0053 0.0143
Echinococcus multilocularis 0.0218 0.04 0.0559
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Brugia malayi hypothetical protein 0.0376 0.0734 0.2397
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0362 0.0704 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0218 0.04 0.1314
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1436 0.2978 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0138 0.0229 0.0314
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0218 0.04 0.5
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0053 0.0088
Loa Loa (eye worm) cytochrome P450 family protein 0.0362 0.0704 0.2296
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0218 0.04 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.028 0.0531 0.1709
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Echinococcus multilocularis tyrosine protein kinase otk 0.0047 0.0037 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Brugia malayi Cytochrome P450 family protein 0.0362 0.0704 0.2296
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0046 0.0064
Loa Loa (eye worm) hypothetical protein 0.028 0.0531 0.1709
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0218 0.04 0.5
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0048 0.0039 0.0041
Schistosoma mansoni sodium/chloride dependent transporter 0.028 0.0531 0.0521
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0006 0.002
Plasmodium falciparum transporter, putative 0.0048 0.0039 0.0253
Schistosoma mansoni sodium-dependent amino acid transporter 0.0048 0.0039 0.0028
Schistosoma mansoni roundabout 0.0047 0.0037 0.0026
Echinococcus granulosus peroxidasin 0.0047 0.0037 0.0038
Schistosoma mansoni cell adhesion molecule 0.0047 0.0037 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.003 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0013 0.0042
Trypanosoma cruzi polo-like protein kinase, putative 0.1436 0.2978 1
Brugia malayi Cytochrome P450 family protein 0.0362 0.0704 0.2296
Echinococcus multilocularis Immunoglobulin 0.0198 0.0358 0.0498
Schistosoma mansoni sodium/chloride dependent transporter 0.0048 0.0039 0.0028
Trypanosoma cruzi cytochrome P450, putative 0.0362 0.0704 0.2338
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0144 0.0242 0.0729
Brugia malayi serine/threonine kinase 12 0.0563 0.1129 0.3735
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.0046 0.0064
Echinococcus granulosus roundabout 2 0.0051 0.0046 0.005
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0045 0.0032 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0053 0.0088
Schistosoma mansoni vesicular amine transporter 0.0198 0.0358 0.0348
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0047 0.0037 0.0033
Echinococcus granulosus cytochrome P450 2K1 0.0218 0.04 0.0559
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0198 0.0358 0.0498
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0053 0.0143
Echinococcus multilocularis serotonin transporter 0.028 0.0531 0.0746
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0053 0.0143
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0218 0.04 0.1314
Echinococcus multilocularis integrin beta 2 0.0205 0.0372 0.0517
Brugia malayi serine/threonine protein kinase 6 0.0563 0.1129 0.3735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0053 0.0178
Entamoeba histolytica protein kinase, putative 0.0563 0.1129 0.377
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0065 0.0075 0.0162
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0218 0.04 0.1314
Loa Loa (eye worm) solute carrier family 6 member 4 0.028 0.0531 0.1709
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0053 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0563 0.1129 0.1603
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0218 0.04 0.1314
Echinococcus granulosus roundabout 2 0.0051 0.0046 0.005
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Trypanosoma cruzi cytochrome P450, putative 0.0362 0.0704 0.2338
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.0253
Loa Loa (eye worm) hypothetical protein 0.0198 0.0358 0.1121
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0051 0.0046 0.005
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0039 0.0041
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Leishmania major cytochrome p450-like protein 0.0362 0.0704 0.2338
Loa Loa (eye worm) hypothetical protein 0.028 0.0531 0.1709
Loa Loa (eye worm) integrin beta-2 0.0276 0.0523 0.1682
Loa Loa (eye worm) cytochrome P450 family protein 0.0882 0.1805 0.6026
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1436 0.2978 0.4252
Echinococcus granulosus contactin 0.0051 0.0046 0.005
Trypanosoma brucei cytochrome P450, putative 0.0362 0.0704 0.2338
Leishmania major cytochrome p450-like protein 0.0218 0.04 0.1314
Echinococcus multilocularis roundabout 2 0.0249 0.0465 0.0652
Schistosoma mansoni integrin beta subunit 0.0163 0.0283 0.0272
Echinococcus multilocularis twitchin 0.0038 0.0018 0.0011
Echinococcus granulosus aurora kinase A 0.0563 0.1129 0.1603
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Schistosoma mansoni sodium/chloride dependent transporter 0.0061 0.0068 0.0057
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0218 0.04 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Entamoeba histolytica protein kinase , putative 0.0563 0.1129 0.377
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0198 0.0358 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0053 0.0178
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1436 0.2978 1
Echinococcus multilocularis hemicentin 1 0.0047 0.0037 0.0037
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0048 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.0203 0.0367 0.1152
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0563 0.1129 0.377
Echinococcus granulosus defective proboscis extension response 0.0198 0.0358 0.0498
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0053 0.0143
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.333 0.6989 1
Loa Loa (eye worm) AUR protein kinase 0.0563 0.1129 0.3735
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.0253
Loa Loa (eye worm) TK protein kinase 0.0162 0.028 0.0859
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0218 0.04 0.5
Echinococcus granulosus integrin beta 2 0.0205 0.0372 0.0517
Mycobacterium leprae putative cytochrome p450 0.0218 0.04 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Schistosoma mansoni protein kinase 0.0563 0.1129 0.112
Echinococcus multilocularis peroxidasin 0.0047 0.0037 0.0038
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0051 0.0046 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Trypanosoma cruzi aurora B kinase, putative 0.0563 0.1129 0.377
Echinococcus multilocularis lachesin 0.0047 0.0037 0.0037
Loa Loa (eye worm) norepinephrine transporter 0.028 0.0531 0.1709
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0007 0.0023
Brugia malayi serine/threonine-protein kinase 6 0.0563 0.1129 0.3735
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0218 0.04 0.5
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0563 0.1129 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0046 0.0064
Brugia malayi Peroxidasin 0.0047 0.0037 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0051 0.0046 0.005
Onchocerca volvulus 0.0048 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Leishmania major protein kinase, putative 0.0563 0.1129 0.377
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.0046 0.005
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0563 0.1129 0.377
Loa Loa (eye worm) AUR protein kinase 0.0563 0.1129 0.3735
Trypanosoma cruzi polo-like protein kinase, putative 0.1436 0.2978 1
Schistosoma mansoni cytochrome P450 0.0218 0.04 0.039
Schistosoma mansoni nephrin 0.0051 0.0046 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.333 0.6989 1
Entamoeba histolytica protein kinase, putative 0.0563 0.1129 0.377
Loa Loa (eye worm) hypothetical protein 0.0199 0.0358 0.1123
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0045 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0245 0.0456 0.1455
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0138 0.0229 0.0314
Brugia malayi Immunoglobulin I-set domain containing protein 0.1267 0.2621 0.8791
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0048 0.0039 0.0041
Brugia malayi Cytochrome P450 family protein 0.0218 0.04 0.1265
Schistosoma mansoni hypothetical protein 0.0043 0.003 0.002
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0138 0.0229 0.0314
Brugia malayi Fibronectin type III domain containing protein 0.0203 0.0367 0.1152
Brugia malayi Immunoglobulin I-set domain containing protein 0.0203 0.0367 0.1152
Loa Loa (eye worm) hypothetical protein 0.0376 0.0734 0.2397
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0047 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0006 0.002
Brugia malayi hypothetical protein 0.0048 0.0039 0.004
Toxoplasma gondii cytochrome p450 superfamily protein 0.0218 0.04 0.3485
Echinococcus granulosus fibroblast growth factor receptor 4 0.0138 0.0229 0.0314
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.003 0.0064
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0218 0.04 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Schistosoma mansoni titin 0.0047 0.0037 0.0026
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0053 0.0061
Schistosoma mansoni tyrosine kinase 0.0067 0.008 0.007
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Echinococcus multilocularis roundabout 2 0.0051 0.0046 0.005
Giardia lamblia Kinase, PLK 0.1436 0.2978 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0053 0.0043
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Echinococcus granulosus tyrosine protein kinase otk 0.0047 0.0037 0.0037
Brugia malayi hypothetical protein 0.0043 0.003 0.0011
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0047 0.0037 0.0026
Echinococcus multilocularis hemicentin 1 0.0047 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0218 0.04 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0218 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0245 0.0456 0.1455
Schistosoma mansoni tyrosine kinase 0.0138 0.0229 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Schistosoma mansoni cell adhesion molecule 0.0051 0.0046 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0053 0.0178
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.028 0.0859
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Loa Loa (eye worm) AUR protein kinase 0.0563 0.1129 0.3735
Echinococcus multilocularis roundabout 2 0.0051 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0563 0.1129 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1267 0.2621 0.8791
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0221 0.0406 0.0566
Toxoplasma gondii hypothetical protein 0.0048 0.0039 0.0253
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1167 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 26.1216 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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